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WO2002003859A1 - Etalonnage transcutane d'un capteur de pression - Google Patents

Etalonnage transcutane d'un capteur de pression Download PDF

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Publication number
WO2002003859A1
WO2002003859A1 PCT/EP2001/007302 EP0107302W WO0203859A1 WO 2002003859 A1 WO2002003859 A1 WO 2002003859A1 EP 0107302 W EP0107302 W EP 0107302W WO 0203859 A1 WO0203859 A1 WO 0203859A1
Authority
WO
WIPO (PCT)
Prior art keywords
pressure sensor
calibration
pressure
flow resistance
implanted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/007302
Other languages
German (de)
English (en)
Inventor
Wolfgang Barnikol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlukoMediTech AG
Original Assignee
GlukoMediTech AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlukoMediTech AG filed Critical GlukoMediTech AG
Priority to AU2001281896A priority Critical patent/AU2001281896A1/en
Publication of WO2002003859A1 publication Critical patent/WO2002003859A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
    • A61B5/02156—Calibration means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/03—Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure ; Measuring pressure in body tissues or organs
    • A61B5/031—Intracranial pressure

Definitions

  • the invention relates to a method with the features of claim 1 and a device for carrying out this method with the features of claim 3. It is thus possible, in particular, an intracranial, for example intraventricular pressure sensor, which is part of a fully implanted drainage system for the cerebrospinal fluid is to calibrate in a bloodless way.
  • an intracranial for example intraventricular pressure sensor, which is part of a fully implanted drainage system for the cerebrospinal fluid is to calibrate in a bloodless way.
  • the liquor is in the pair, so-called.
  • the choroid plexus of the 1st and 2nd ventricles is formed and flows into the venous blood in various ways: via the arachnoid granulation and the interventricular foramina in the 3rd ventricle and further via the cerebral aqueduct in the 4th brain ventricle.
  • the formation and drainage of the brain water are usually coordinated so that a proper one in the brain water
  • intracranial intracranial pressure also depends on the position and is physiologically 10 ⁇ 5mmHg in the lying adult.
  • the cerebrospinal fluid pressure also increases due to a decrease in cerebrospinal fluid absorption (Hydrocephalus aresorptivus) after meningitis or encephalitis; the Increases also result from an increase in the resistance to outflow (hydrocephalus occlucus) in the event of malformations and from tumors. Finally, the intracranial pressure increases with increased cerebrospinal fluid production (Hydrocephalus hypersecretorius), for example due to toxic influences on the brain. Further detailed explanations on pathophysiology, the clinic but also measurement technology and their problems can be found in S. Schwab, D. Krieger, W. Müllgas, G. Haman, W. hacke (ed.), "Neurological Intensive Care Medicine", chap. 14, P. 271 f., Springer-Verlag, 1999.ISBN 3-54065412-7.
  • a thin tube with an outer diameter of approximately 2.5 mm is used a CSF drainage (so-called, cerebral "shunt").
  • the tube is located at one end in one of the two lateral and paired intracerebral CSF spaces (so-called brain ventricles) and leads out through the skull cap; it usually runs under the skin to the abdomen.
  • a measuring and calibration device for calibrating pressure sensors for measuring the pressure in the brain in the non-implanted or implanted state is known.
  • a reference pressure is applied via a reference pressure channel with the aid of a pressure transmitter, this is measured via a reference pressure sensor, and the pressure sensor is therefore calibrated and calibrated using electronics.
  • a transcutaneously implanted pressure sensor is known in which the intracranial pressure is determined with the aid of a pressure reservoir on the skin and an audio signal resulting from the pressure difference between the internal pressure and the pressure on the skin surface due to mechanical contact.
  • the resistance is set according to clinical experience, taking into account the above symptoms. There is currently no way for clinical routine to measure the intracranial pressure without a transcutaneous probe and even to record a long-term profile of this pressure (diagnostic working mode), which would be of the greatest diagnostic and consequently therapeutic interest for the patient concerned. Likewise, it would be of great advantage if (with stabilized pressure,
  • the desired system for stabilizing the intracranial pressure is to be integrated into a cerebrospinal fluid drainage
  • only a micro pressure sensor can be used for pressure measurement, which is best integrated at the tip of the implanted catheter of the cerebrospinal fluid drainage so that its pressure-sensitive area is facing the cerebral cerebrospinal fluid space.
  • Stabilization in the form of a negative feedback with the help of a controllable flow resistance in the working hose of the drainage should function properly for years; for this it is particularly important that the sensitivity and in particular the zero point of the fully integrated and implanted pressure sensor remain stable for years - a problem that cannot be solved practically, even if the pressure sensors are designed to be as stable as possible. Therefore, the fully implanted system must have a device with which the calibration of the
  • Pressure sensor can be checked at any time and corrected if necessary. At the moment there is no possibility for the clinical routine to adjust such a pressure microsensor implanted in situ, either bloody and certainly not bloodless.
  • the reliable display of the pressure over a long period of time by the (intraventricularly lying) sensor is so important because, for example, an incorrectly too low pressure signal would cause the negative feedback mechanism to set a much too high intracranial one and thus damage the brain. Under certain circumstances it would be less harmful not to take any iatrogenic measures. So if you get involved in a technical stabilization of the cerebrospinal fluid pressure, the permanently correct pressure detection is extremely important. This emphatically underlines the demand for the pressure signal to be checked at all times.
  • a control can be achieved with the help of a subcutaneous puncture system integrated in the drainage.
  • a skin area can only be punctured to a limited extent, apart from the risk of infection and apart from the discomfort for the patient concerned.
  • Optimal would be the possibility of a bloodless calibration, which could be repeated as often as desired and practically without risk.
  • the problem is solved according to the invention by a calibration, measuring and control device which is switched on in the working tube of the liquor and under the skin lies.
  • the fully implanted part of the device can equally serve to control the CSF flow for the purpose of stabilizing the intracranial pressure and to measure this flow as well as a bloody calibration - as an alternative to the bloodless one.
  • Both devices enable a method of a bloodless calibration of an implanted pressure sensor, such as a micro pressure sensor located in the brain ventricle.
  • FIG. 1 and 2 show the device schematically for the case of use in intracranial pressure measurement: FIG. 1 shows a longitudinal section through the entire structure and FIG. 2 shows a top view of the calibration, measurement and control device ,
  • the measuring and control device (1) is located directly below the
  • CSF tube usually runs.
  • Your capsule (1.2) has the shape of a thin disc, which has a hose attachment for the CSF supply (1.3) and another one for the drain (1.4).
  • the end of the supply tube (3) lies in the brain ventricle, at the end of which is the pressure microsensor; the drain hose (4) ends in the abdominal cavity.
  • the two hose attachments go into the inner tube (1.5) of the measuring and control device (1).
  • This tube - seen from the side of the CSF inflow - is initially a subcutaneous one
  • Another element is a differential pressure sensor (1.9) which, with sufficient sensitivity, is a pressure difference between the interior of the device 1 and the Can signal inside the calibration hood (2).
  • the sensor membrane of this differential pressure sensor (1.9) lies directly against the inside of the skin (5).
  • a flow sensor (1.10) is installed in the pipe behind the second flow resistance. This is followed by the drainage approach (1.4), the attached tube of which opens into the abdomen.
  • Both flow resistances can be operated externally; the signals from the differential pressure sensor (1.2) and from the flow sensor (1.10) can be received telemetrically outside the organism.
  • the calibration hood (2) is used for bloodless calibration of the intracranial pressure microsensor. It preferably has a circular base (2.1) which fits exactly on the circular edge of the measuring and control device (1). The seal between the two devices is ensured by the skin under pressure.
  • the calibration hood (2) has a manometer (2.2) with which the internal pressure of the hood can be determined; it also has a pump device (2.3), with the aid of which a certain positive or negative pressure can be set inside the calibration hood, which in turn can be measured with the manometer (2.2).
  • the pump device is connected to the hood via a hose (2.4). This has a compensation flap (2.5) for pressure compensation with the surroundings.
  • the calibration hood (2) is placed on the device (1) and pressed there; In the calibration hood there is initially a balance with the air pressure, which can be achieved by opening the compensation flap (2.5). Then the flow resistance (1.8.1) is closed and the pressure range of the intracranial pressure sensor is decoupled from the pressure differential sensor. Therefore the differential pressure sensor (1.9) now shows its zero signal, which can be set to zero, but does not have to. The flow sensor (1.10) also indicates its zero signal. Then the river Resistor (1.8.2) also closed; the zero signal from the differential pressure sensor (1.9) should be retained, as should the signal from the flow sensor (1.10). After opening the flow resistance (1.8.1), the pressure of the brain ventricle acts on the differential pressure sensor (1.9): Its display then changes accordingly.
  • the compensating flap (2.5) is closed and the pump device (2.3) inside the calibration hood generates a pressure such that the differential pressure sensor 1.9 again displays the zero signal.
  • the pressure required inside the hood which can be determined directly with the calibrated manometer (2.2), is equal to the pressure in the brain ventricle.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention concerne un procédé d'étalonnage transcutané d'un capteur de pression implanté, selon lequel on place sur la peau, sur un dispositif de mesure et de commande (1) implanté qui comprend une première résistance directe (1.8.1), un capteur de pression différentielle (1.9), une seconde résistance directe (1.8.2) et un capteur de flux (1.10), un capot d'étalonnage (2) comportant un manomètre (2.2) et un dispositif de pompage (2.3) avec un volet de compensation (2.5) monté dans le flexible d'alimentation (2,4). L'ouverture du volet de compensation (2.5) permet d'ajuster la pression d'air extérieur dans le capot d'étalonnage (2), de fermer la résistance directe (1.8.1), ainsi que la seconde résistance directe (1.8.2). La première résistance directe (1.8.1) est à nouveau ouverte, une pression est produite avec le dispositif de pompage (2.3) dans le capot d'étalonnage (2), de manière que le capteur de pression différentielle (1.9) indique à nouveau le signal pour ouvrir la première résistance directe (1.8.1) et la pression régnant dans le capot d'étalonnage (2) est déterminée avec le manomètre (2.2). L'invention concerne en outre un dispositif permettant de mettre ledit procédé en oeuvre.
PCT/EP2001/007302 2000-07-07 2001-06-26 Etalonnage transcutane d'un capteur de pression Ceased WO2002003859A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001281896A AU2001281896A1 (en) 2000-07-07 2001-06-26 Transcutaneous calibration of an implanted pressure sensor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2000133139 DE10033139A1 (de) 2000-07-07 2000-07-07 Verfahren zur transkutanen Eichung eines implantierten Drucksensors und Vorrichtung zu seiner Durchführung
DE10033139.4 2000-07-07

Publications (1)

Publication Number Publication Date
WO2002003859A1 true WO2002003859A1 (fr) 2002-01-17

Family

ID=7648185

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007302 Ceased WO2002003859A1 (fr) 2000-07-07 2001-06-26 Etalonnage transcutane d'un capteur de pression

Country Status (3)

Country Link
AU (1) AU2001281896A1 (fr)
DE (1) DE10033139A1 (fr)
WO (1) WO2002003859A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9668663B2 (en) 2014-03-24 2017-06-06 Arkis Biosciences Implantable dual sensor bio-pressure transponder and method of calibration

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4378809A (en) 1978-04-13 1983-04-05 Cosman Eric R Audio-telemetric pressure sensing systems and methods
DE9105742U1 (de) 1991-05-08 1991-07-04 Keller AG für Druckmeßtechnik, Winterthur Meß- und Kalibriergerät zum Abgleich von mittels in Körpern von Lebewesen implantierbaren Drucksensoren ermittelten Meßsignalen
DE4115134A1 (de) * 1990-05-10 1991-11-14 Nippon Mdm Kk Verfahren zur messung des intrakraniellen drucks und eine vorrichtung zur durchfuehrung dieses verfahrens

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4378809A (en) 1978-04-13 1983-04-05 Cosman Eric R Audio-telemetric pressure sensing systems and methods
DE4115134A1 (de) * 1990-05-10 1991-11-14 Nippon Mdm Kk Verfahren zur messung des intrakraniellen drucks und eine vorrichtung zur durchfuehrung dieses verfahrens
DE9105742U1 (de) 1991-05-08 1991-07-04 Keller AG für Druckmeßtechnik, Winterthur Meß- und Kalibriergerät zum Abgleich von mittels in Körpern von Lebewesen implantierbaren Drucksensoren ermittelten Meßsignalen

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9668663B2 (en) 2014-03-24 2017-06-06 Arkis Biosciences Implantable dual sensor bio-pressure transponder and method of calibration
US10791944B2 (en) 2014-03-24 2020-10-06 Arkis Biosciences Inc. Implantable dual sensor bio-pressure transponder and method of calibration

Also Published As

Publication number Publication date
AU2001281896A1 (en) 2002-01-21
DE10033139A1 (de) 2002-01-31

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