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WO2002003848A3 - Method for opening the blood-brain barrier - Google Patents

Method for opening the blood-brain barrier Download PDF

Info

Publication number
WO2002003848A3
WO2002003848A3 PCT/US2001/019654 US0119654W WO0203848A3 WO 2002003848 A3 WO2002003848 A3 WO 2002003848A3 US 0119654 W US0119654 W US 0119654W WO 0203848 A3 WO0203848 A3 WO 0203848A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood
brain barrier
opening
sugar
nervous system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/019654
Other languages
French (fr)
Other versions
WO2002003848A2 (en
WO2002003848A8 (en
Inventor
Albert T Naito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP01950344A priority Critical patent/EP1298994A2/en
Priority to JP2002508310A priority patent/JP2004502706A/en
Priority to AU2001271345A priority patent/AU2001271345A1/en
Publication of WO2002003848A2 publication Critical patent/WO2002003848A2/en
Publication of WO2002003848A3 publication Critical patent/WO2002003848A3/en
Anticipated expiration legal-status Critical
Publication of WO2002003848A8 publication Critical patent/WO2002003848A8/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Oral administritration of sugar opens the blood-brain barrier and permits a co-administered chemical compound to enter the central nervous system in a higher amount than occurs without co-administration of the sugar. The increased amount that enters the central nervous system results in an increased biologic effect of the chemical compound.
PCT/US2001/019654 2000-07-10 2001-06-19 Method for opening the blood-brain barrier Ceased WO2002003848A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01950344A EP1298994A2 (en) 2000-07-10 2001-06-19 Method for opening the blood-brain barrier
JP2002508310A JP2004502706A (en) 2000-07-10 2001-06-19 How to open the blood-brain barrier
AU2001271345A AU2001271345A1 (en) 2000-07-10 2001-06-19 Method for opening the blood-brain barrier

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61321200A 2000-07-10 2000-07-10
US09/613,212 2000-07-10

Publications (3)

Publication Number Publication Date
WO2002003848A2 WO2002003848A2 (en) 2002-01-17
WO2002003848A3 true WO2002003848A3 (en) 2002-08-15
WO2002003848A8 WO2002003848A8 (en) 2003-11-06

Family

ID=24456335

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/019654 Ceased WO2002003848A2 (en) 2000-07-10 2001-06-19 Method for opening the blood-brain barrier

Country Status (4)

Country Link
EP (1) EP1298994A2 (en)
JP (1) JP2004502706A (en)
AU (1) AU2001271345A1 (en)
WO (1) WO2002003848A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003327528A (en) * 2002-03-04 2003-11-19 Pharmafoods Kenkyusho:Kk Immunocompetence-improving composition
EP1576141A4 (en) * 2002-05-14 2006-03-22 Bristol Myers Squibb Co Polynucleotide encoding novel human g-protein coupled receptors, and splice variants thereof
US8796441B2 (en) 2005-04-13 2014-08-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human sweet and umami taste receptor variants
US20070072795A1 (en) * 2005-09-28 2007-03-29 Anton Haselbeck Treatment of neurodegenerative disorders
AU2015259362B2 (en) 2014-05-12 2018-02-15 The Johns Hopkins University Engineering synthetic brain penetrating gene vectors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643773A (en) * 1984-03-09 1987-02-17 A. E. Staley Manufacturing Company Crystallization of fructose utilizing a mixture of alcohols
US4897380A (en) * 1985-08-30 1990-01-30 Pollack Robert L Method and composition for relieving dietary-related disorders
JPH0352810A (en) * 1989-07-20 1991-03-07 T Knight Albert Substance passing through blood- brain barrier
US5480865A (en) * 1994-02-25 1996-01-02 Parkinson's Charitable Trust Nutritional composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643773A (en) * 1984-03-09 1987-02-17 A. E. Staley Manufacturing Company Crystallization of fructose utilizing a mixture of alcohols
US4897380A (en) * 1985-08-30 1990-01-30 Pollack Robert L Method and composition for relieving dietary-related disorders
JPH0352810A (en) * 1989-07-20 1991-03-07 T Knight Albert Substance passing through blood- brain barrier
US5480865A (en) * 1994-02-25 1996-01-02 Parkinson's Charitable Trust Nutritional composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE (COLUMBUS, OHIO, USA); KNIGHT A.T.: "Sugars and amino acids as carriers of therapeutic agents in blood-brain carriers", XP002950325, accession no. STN Database accession no. 1991:614851 *

Also Published As

Publication number Publication date
JP2004502706A (en) 2004-01-29
WO2002003848A2 (en) 2002-01-17
EP1298994A2 (en) 2003-04-09
AU2001271345A1 (en) 2002-01-21
WO2002003848A8 (en) 2003-11-06

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