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WO2002000700A3 - Regulation of human p2y8-like g protein-coupled receptor - Google Patents

Regulation of human p2y8-like g protein-coupled receptor Download PDF

Info

Publication number
WO2002000700A3
WO2002000700A3 PCT/EP2001/007204 EP0107204W WO0200700A3 WO 2002000700 A3 WO2002000700 A3 WO 2002000700A3 EP 0107204 W EP0107204 W EP 0107204W WO 0200700 A3 WO0200700 A3 WO 0200700A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
asthma
disease
coupled receptor
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/007204
Other languages
French (fr)
Other versions
WO2002000700A2 (en
Inventor
Shyam Ramakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU8188101A priority Critical patent/AU8188101A/en
Priority to EP01960372A priority patent/EP1297140A2/en
Publication of WO2002000700A2 publication Critical patent/WO2002000700A2/en
Publication of WO2002000700A3 publication Critical patent/WO2002000700A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reagents which regulate human P2Y8-like G protein-coupled receptor can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, infections such as bacterial, fungal, protozoan, and viral infections, particularly those caused by HIV viruses, pain, cancers, anorexia, bulimia, asthma, CNS diseases such as Parkinson's disease, acute heart failure, hypotension, hypertension, urinary retention, osteoporosis, diabetes, angina pectoris, myocardial infarction, ulcers, asthma, inflammation, allergies, multiple sclerosis, benign prostatic hypertrophy, and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, several mental retardation, and dyskinesias, such as Huntington's disease and Tourett's syndrome.
PCT/EP2001/007204 2000-06-26 2001-06-25 Regulation of human p2y8-like g protein-coupled receptor Ceased WO2002000700A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU8188101A AU8188101A (en) 2000-06-26 2001-06-25 Regulation of human p2y8-like g protein-coupled receptor
EP01960372A EP1297140A2 (en) 2000-06-26 2001-06-25 Regulation of human p2y8-like g protein-coupled receptor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21425700P 2000-06-26 2000-06-26
US60/214,257 2000-06-26
US25487800P 2000-12-13 2000-12-13
US60/254,878 2000-12-13

Publications (2)

Publication Number Publication Date
WO2002000700A2 WO2002000700A2 (en) 2002-01-03
WO2002000700A3 true WO2002000700A3 (en) 2002-07-04

Family

ID=26908824

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/007204 Ceased WO2002000700A2 (en) 2000-06-26 2001-06-25 Regulation of human p2y8-like g protein-coupled receptor

Country Status (3)

Country Link
EP (1) EP1297140A2 (en)
AU (1) AU8188101A (en)
WO (1) WO2002000700A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997019170A1 (en) * 1995-11-21 1997-05-29 Euroscreen S.A. Receptor and nucleic acid molecule encoding said receptor
WO2000011170A1 (en) * 1998-08-20 2000-03-02 Millennium Pharmaceuticals, Inc. 14400 receptor, a g-protein coupled receptor
WO2000020438A1 (en) * 1998-10-02 2000-04-13 Merck & Co., Inc. G protein-coupled receptor resembling the thrombin receptor
WO2001025280A1 (en) * 1999-10-06 2001-04-12 Smithkline Beecham Corporation Paul, a g-protein coupled receptor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997019170A1 (en) * 1995-11-21 1997-05-29 Euroscreen S.A. Receptor and nucleic acid molecule encoding said receptor
WO2000011170A1 (en) * 1998-08-20 2000-03-02 Millennium Pharmaceuticals, Inc. 14400 receptor, a g-protein coupled receptor
WO2000020438A1 (en) * 1998-10-02 2000-04-13 Merck & Co., Inc. G protein-coupled receptor resembling the thrombin receptor
WO2001025280A1 (en) * 1999-10-06 2001-04-12 Smithkline Beecham Corporation Paul, a g-protein coupled receptor

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ADRIAN K ET AL.: "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells", BIOCHIMICA ET BIOPHYSICA ACTA. GENE STRUCTURE AND EXPRESSION, vol. 1492, no. 1, 21 June 2000 (2000-06-21), pages 127 - 138, XP004275665, ISSN: 0167-4781 *
BOGDANOV Y D ET AL.: "Early expression of a novel nucleotide receptor in the neural plate of Xenopus embryos", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 19, 9 May 1997 (1997-05-09), pages 12583 - 12590, XP002195828 *
DATABASE EM_EST EMBL; 16 February 1998 (1998-02-16), NCI-CGAP: "ns28c04.s1 NCI_CGAP_GCB1 Homo sapiens cDNA clone IMAGE:1184934 3' similar to TR:P79928 P79928 P2Y8 NUCLEOTIDE RECEPTOR. ;, mRNA sequence.", XP002195829 *
DATABASE SWALL EMBL; 1 November 1997 (1997-11-01), BOGDANOV Y D ET AL.: "P2Y PURINOCEPTOR 8 (P2Y8) Xenopus laevis (African clawed frog)", XP002195830 *
WILSON S ET AL.: "Orphan G-protein-coupled receptors: the next generation of drug targets?", BRITISH JOURNAL OF PHARMACOLOGY, vol. 125, no. 7, December 1998 (1998-12-01), pages 1387 - 1392, XP001010584, ISSN: 0007-1188 *

Also Published As

Publication number Publication date
WO2002000700A2 (en) 2002-01-03
EP1297140A2 (en) 2003-04-02
AU8188101A (en) 2002-01-08

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