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WO2002000164A3 - Chemosensitizer - Google Patents

Chemosensitizer Download PDF

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Publication number
WO2002000164A3
WO2002000164A3 PCT/IB2001/001133 IB0101133W WO0200164A3 WO 2002000164 A3 WO2002000164 A3 WO 2002000164A3 IB 0101133 W IB0101133 W IB 0101133W WO 0200164 A3 WO0200164 A3 WO 0200164A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemotherapeutic agents
found
group
agents
chemosensitizer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2001/001133
Other languages
French (fr)
Other versions
WO2002000164A8 (en
WO2002000164A2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EA200200288A priority Critical patent/EA005672B1/en
Priority to EP01940915A priority patent/EP1296682A4/en
Priority to AU74403/01A priority patent/AU7440301A/en
Priority to APAP/P/2002/002453A priority patent/AP2002002453A0/en
Publication of WO2002000164A2 publication Critical patent/WO2002000164A2/en
Publication of WO2002000164A8 publication Critical patent/WO2002000164A8/en
Publication of WO2002000164A3 publication Critical patent/WO2002000164A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Chemotherapeutic agents are used to treat infections caused by bacteria, virus, protozoa, parasites, and various malignant diseases like cancer. The major problem associated with use of chemotherapeutic agents is resistance to chemoptherapeutic agents. The drugs restoring sensitivity of chemotherapeutic agents are broadly known as chemosensitizers. Compounds belonging to a group of R-1-3-benzodiaxole are found to be chemosensitizer as per the present invention. Piperine is one such compound belonging to R-1-2benzodiaxole group. It is found to reverse resistance to chemotherapeutic agents like rifampicin at a dose which is easily achievable after oral ingestion of the drug.
PCT/IB2001/001133 2000-06-26 2001-06-26 Chemosensitizer Ceased WO2002000164A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EA200200288A EA005672B1 (en) 2000-06-28 2001-06-26 Chemosensitizer
EP01940915A EP1296682A4 (en) 2000-06-28 2001-06-26 Chemosensitizer
AU74403/01A AU7440301A (en) 2000-06-26 2001-06-26 Chemosensitizer
APAP/P/2002/002453A AP2002002453A0 (en) 2000-06-28 2001-06-26 Chemosensitizer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN591/MUM/2000 2000-06-28
IN591MU2000 2000-06-28

Publications (3)

Publication Number Publication Date
WO2002000164A2 WO2002000164A2 (en) 2002-01-03
WO2002000164A8 WO2002000164A8 (en) 2002-05-16
WO2002000164A3 true WO2002000164A3 (en) 2002-10-24

Family

ID=11097259

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/001133 Ceased WO2002000164A2 (en) 2000-06-26 2001-06-26 Chemosensitizer

Country Status (6)

Country Link
EP (1) EP1296682A4 (en)
AP (1) AP2002002453A0 (en)
AU (1) AU7440301A (en)
EA (1) EA005672B1 (en)
RU (1) RU2002107449A (en)
WO (1) WO2002000164A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100425236C (en) * 2003-03-31 2008-10-15 科学与工业研究委员会 Use of cuminum cyminum extract and piperine for potentiaion of bioeffectacy of anti infectives
US8580752B2 (en) * 2005-03-31 2013-11-12 Council Of Scientitic And Industrial Research Aromatic amides as potentiators of bioefficacy of anti-infective drugs
US8440625B2 (en) 2006-06-26 2013-05-14 University Of British Columbia Secreted protein acidic and rich in cysteine (SPARC) as chemotherapeutic sensitizers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN176897B (en) * 1993-10-29 1996-09-28 Cadila Lab Ltd
US5439891A (en) * 1993-10-29 1995-08-08 Kapil; Randhir S. Process for preparation of pharmaceutical composition with enhanced activity for treatment of tuberculosis and leprosy
US5744161A (en) * 1995-02-24 1998-04-28 Sabinsa Corporation Use of piperine as a bioavailability enhancer
EP0935964A1 (en) * 1998-02-12 1999-08-18 Panacea Biotec Limited Pharmaceutical compositions containing NSAIDs and piperine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CANCER LETTERS, vol. 64, no. 3, 1992, pages 235 - 239 *
DATABASE CAPLUS [online] SHENOY ET AL.: "Characterization of potentially mutagenic products from the nitrosation of perperin", XP002908374, accession no. STN Database accession no. 117:212755 *

Also Published As

Publication number Publication date
RU2002107449A (en) 2003-11-20
AU7440301A (en) 2002-01-08
AP2002002453A0 (en) 2002-06-30
EP1296682A4 (en) 2004-11-10
EA005672B1 (en) 2005-04-28
WO2002000164A8 (en) 2002-05-16
WO2002000164A2 (en) 2002-01-03
EA200200288A1 (en) 2003-02-27
EP1296682A2 (en) 2003-04-02

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