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WO2002090378A3 - Haplotypes of the ces2 gene - Google Patents

Haplotypes of the ces2 gene Download PDF

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Publication number
WO2002090378A3
WO2002090378A3 PCT/US2002/014813 US0214813W WO02090378A3 WO 2002090378 A3 WO2002090378 A3 WO 2002090378A3 US 0214813 W US0214813 W US 0214813W WO 02090378 A3 WO02090378 A3 WO 02090378A3
Authority
WO
WIPO (PCT)
Prior art keywords
ces2
gene
haplotypes
disclosed
haplotyping
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/014813
Other languages
French (fr)
Other versions
WO2002090378A2 (en
Inventor
Christopher Raleigh Gilson
Amir Kazemi
David P Russo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cogenics Inc
Original Assignee
Genaissance Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals Inc filed Critical Genaissance Pharmaceuticals Inc
Priority to AU2002303699A priority Critical patent/AU2002303699A1/en
Publication of WO2002090378A2 publication Critical patent/WO2002090378A2/en
Publication of WO2002090378A3 publication Critical patent/WO2002090378A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Novel genetic variants of the Carboxylesterase 2 (CES2) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the CES2 gene. Compositions and methods for haplotyping and/or genotyping the CES2 gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
PCT/US2002/014813 2001-05-09 2002-05-09 Haplotypes of the ces2 gene Ceased WO2002090378A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002303699A AU2002303699A1 (en) 2002-05-09 2002-05-09 Haplotypes of the ces2 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28988601P 2001-05-09 2001-05-09
US60/289,886 2001-05-09

Publications (2)

Publication Number Publication Date
WO2002090378A2 WO2002090378A2 (en) 2002-11-14
WO2002090378A3 true WO2002090378A3 (en) 2003-02-13

Family

ID=23113549

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/014813 Ceased WO2002090378A2 (en) 2001-05-09 2002-05-09 Haplotypes of the ces2 gene

Country Status (1)

Country Link
WO (1) WO2002090378A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002312241A1 (en) * 2001-06-05 2002-12-16 Exelixis, Inc. B3galts as modifiers of the p53 pathway and methods of use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AMERICAN JOURNAL OF HUMAN GENETICS, vol. 69, no. 4, October 2001 (2001-10-01), pages 364 *
DATABASE BIOSIS [online] MARSH ET AL.: "Carboxylesterase 2 pharmacogenetics: intron/exon boundaries and polymorphism analysis", XP002957252, Database accession no. 2001:539597 *
DATABASE LOCUS [online] 1 August 2002 (2002-08-01), "Direct submission", XP002957259, accession no. NCBI Database accession no. NT_010478 *
PINDEL ET AL.: "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 23, 6 June 1997 (1997-06-06), pages 14769 - 14775, XP002135538 *

Also Published As

Publication number Publication date
WO2002090378A2 (en) 2002-11-14

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