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WO2002083616A1 - α-SUBSTITUTED φ-ARYLFATTY ACID DERIVATIVE - Google Patents

α-SUBSTITUTED φ-ARYLFATTY ACID DERIVATIVE Download PDF

Info

Publication number
WO2002083616A1
WO2002083616A1 PCT/JP2002/003557 JP0203557W WO02083616A1 WO 2002083616 A1 WO2002083616 A1 WO 2002083616A1 JP 0203557 W JP0203557 W JP 0203557W WO 02083616 A1 WO02083616 A1 WO 02083616A1
Authority
WO
WIPO (PCT)
Prior art keywords
substituted
arylfatty
acid derivative
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/003557
Other languages
French (fr)
Japanese (ja)
Inventor
Hiroshi Kurobe
Tetsuji Nunozawa
Tomokadu Sugawara
Koei Moriguchi
Takeshi Endo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of WO2002083616A1 publication Critical patent/WO2002083616A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A compound having the following structural formula (I): (I) wherein Ar is substituted phenyl, etc.; R1 is alkoxy, alkyl, etc.; R2 is hydrogen, alkyl, etc.; R?3 and R4¿ each is hydrogen or halogeno; m is 1 or 2; and n is 2 to 7. It is useful as a remedy and/or preventive for diabetes.
PCT/JP2002/003557 2001-04-10 2002-04-09 α-SUBSTITUTED φ-ARYLFATTY ACID DERIVATIVE Ceased WO2002083616A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001110815 2001-04-10
JP2001-110815 2001-04-10

Publications (1)

Publication Number Publication Date
WO2002083616A1 true WO2002083616A1 (en) 2002-10-24

Family

ID=18962516

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/003557 Ceased WO2002083616A1 (en) 2001-04-10 2002-04-09 α-SUBSTITUTED φ-ARYLFATTY ACID DERIVATIVE

Country Status (1)

Country Link
WO (1) WO2002083616A1 (en)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003051821A1 (en) * 2001-12-19 2003-06-26 Astrazeneca Ab Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
WO2004106276A1 (en) * 2003-05-30 2004-12-09 Takeda Pharmaceutical Company Limited Condensed ring compound
WO2007056771A2 (en) 2005-11-09 2007-05-18 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
JP2007516267A (en) * 2003-12-15 2007-06-21 イーライ リリー アンド カンパニー Selective peroxisome proliferator-activated receptor modulators
US7371777B2 (en) 2001-08-17 2008-05-13 Eisai Co., Ltd. Cyclic compound and PPAR agonist
US7456218B2 (en) 2003-12-25 2008-11-25 Takeda Pharmaceutical Company Limited 3-(4-benzyloxyphenyl) propanoic acid derivatives
US7462644B2 (en) 2002-12-21 2008-12-09 Astrazeneca Ab Therapeutic agents
US7488844B2 (en) 2001-12-19 2009-02-10 Astrazeneca Ab Therapeutic agents
US7544835B2 (en) 2001-04-20 2009-06-09 Eisai R&D Management Co., Ltd. Carboxylic acid derivative and salt thereof
US7553867B2 (en) 2002-09-06 2009-06-30 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
US7585880B2 (en) 2003-12-26 2009-09-08 Takeda Pharmaceutical Company Limited Phenylpropanoic acid derivatives
EP1559422A4 (en) * 2002-11-08 2010-02-24 Takeda Pharmaceutical CONTROLLER OF RECEIVER FUNCTION
US8008525B2 (en) 2003-11-26 2011-08-30 Takeda Pharmaceutical Company Limited Receptor function regulating agent
CN103547555A (en) * 2011-05-26 2014-01-29 Dic株式会社 Compound having 2-fluorophenyloxymethane structure
PL424227A1 (en) * 2018-01-08 2019-07-15 Celon Pharma Spółka Akcyjna Derivatives of 3-phenyl-4-hexynoic acid as GPR40 agonists

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050392A1 (en) * 1999-02-24 2000-08-31 Sankyo Company, Limited 2-mercaptocarboxylic acid derivatives
JP2002068977A (en) * 2000-08-23 2002-03-08 Sankyo Co Ltd Prophylactic and therapeutic agent for diabetes containing 2-mercaptocarboxylic acid derivative

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050392A1 (en) * 1999-02-24 2000-08-31 Sankyo Company, Limited 2-mercaptocarboxylic acid derivatives
JP2002068977A (en) * 2000-08-23 2002-03-08 Sankyo Co Ltd Prophylactic and therapeutic agent for diabetes containing 2-mercaptocarboxylic acid derivative

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7544835B2 (en) 2001-04-20 2009-06-09 Eisai R&D Management Co., Ltd. Carboxylic acid derivative and salt thereof
US7371777B2 (en) 2001-08-17 2008-05-13 Eisai Co., Ltd. Cyclic compound and PPAR agonist
US7514471B2 (en) 2001-12-19 2009-04-07 Astrazeneca Ab Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor α (PPAR)
WO2003051822A1 (en) * 2001-12-19 2003-06-26 Astrazeneca Ab Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
US7488844B2 (en) 2001-12-19 2009-02-10 Astrazeneca Ab Therapeutic agents
US7256307B2 (en) 2001-12-19 2007-08-14 Astrazeneca Ab Substituted phenypropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor α(PPAR)
WO2003051821A1 (en) * 2001-12-19 2003-06-26 Astrazeneca Ab Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
US7553867B2 (en) 2002-09-06 2009-06-30 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
EP2385032A1 (en) * 2002-11-08 2011-11-09 Takeda Pharmaceutical Company Limited GPR40 Receptor function regulator
US7960369B2 (en) 2002-11-08 2011-06-14 Takeda Pharmaceutical Company Limited Receptor function regulator
EP1559422A4 (en) * 2002-11-08 2010-02-24 Takeda Pharmaceutical CONTROLLER OF RECEIVER FUNCTION
US7462644B2 (en) 2002-12-21 2008-12-09 Astrazeneca Ab Therapeutic agents
WO2004106276A1 (en) * 2003-05-30 2004-12-09 Takeda Pharmaceutical Company Limited Condensed ring compound
US7820837B2 (en) * 2003-05-30 2010-10-26 Takeda Pharmaceutical Company Limited Condensed ring compound
US8008525B2 (en) 2003-11-26 2011-08-30 Takeda Pharmaceutical Company Limited Receptor function regulating agent
JP2007516267A (en) * 2003-12-15 2007-06-21 イーライ リリー アンド カンパニー Selective peroxisome proliferator-activated receptor modulators
US7456218B2 (en) 2003-12-25 2008-11-25 Takeda Pharmaceutical Company Limited 3-(4-benzyloxyphenyl) propanoic acid derivatives
US7585880B2 (en) 2003-12-26 2009-09-08 Takeda Pharmaceutical Company Limited Phenylpropanoic acid derivatives
US8178675B2 (en) 2005-11-09 2012-05-15 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
EP1948152A4 (en) * 2005-11-09 2010-07-07 Wellstat Therapeutics Corp Compounds for the treatment of metabolic disorders
AU2006311266B2 (en) * 2005-11-09 2011-09-29 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
JP2009514987A (en) * 2005-11-09 2009-04-09 ウェルスタット セラピューティクス コーポレイション Compounds for the treatment of metabolic disorders
WO2007056771A2 (en) 2005-11-09 2007-05-18 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CN103547555A (en) * 2011-05-26 2014-01-29 Dic株式会社 Compound having 2-fluorophenyloxymethane structure
CN103547555B (en) * 2011-05-26 2014-12-10 Dic株式会社 Compound having 2-fluorophenyloxymethane structure
PL424227A1 (en) * 2018-01-08 2019-07-15 Celon Pharma Spółka Akcyjna Derivatives of 3-phenyl-4-hexynoic acid as GPR40 agonists

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