[go: up one dir, main page]

WO2002068000A3 - Polymeric imagable brachytherapy seed - Google Patents

Polymeric imagable brachytherapy seed Download PDF

Info

Publication number
WO2002068000A3
WO2002068000A3 PCT/US2001/043517 US0143517W WO02068000A3 WO 2002068000 A3 WO2002068000 A3 WO 2002068000A3 US 0143517 W US0143517 W US 0143517W WO 02068000 A3 WO02068000 A3 WO 02068000A3
Authority
WO
WIPO (PCT)
Prior art keywords
brachytherapy
seeds
implantation
seed
diagnostic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/043517
Other languages
French (fr)
Other versions
WO2002068000A2 (en
Inventor
Edward J Kaplan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microspherix LLC
Original Assignee
Microspherix LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/861,326 external-priority patent/US6746661B2/en
Application filed by Microspherix LLC filed Critical Microspherix LLC
Priority to AU2001297657A priority Critical patent/AU2001297657A1/en
Priority to EP01273840A priority patent/EP1372742A2/en
Publication of WO2002068000A2 publication Critical patent/WO2002068000A2/en
Anticipated expiration legal-status Critical
Publication of WO2002068000A3 publication Critical patent/WO2002068000A3/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N5/1027—Interstitial radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6957—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a device or a kit, e.g. stents or microdevices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A61N2005/1023—Means for creating a row of seeds, e.g. spacers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A61N2005/1019—Sources therefor
    • A61N2005/1024—Seeds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A brachytherapy seed that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a polymeric carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Because the brachytherapy seeds can be sized and shaped to fit through the bore of a brachytherapy implantation needle, they are suitable for use with brachytherapy seed implantation instruments. A drug or other therapeutically active substance or diagnostic can be included in the seed in addition to, or as an alternative to, a radioisotope. The rate of release in the implantation site can be controlled by controlling the rate of degradation and/or release at the implantation site. In the preferred embodiment, the seeds also contain a radioopaque material or other means for external imaging. Like conventional radioactive brachytherapy seeds, the seeds can be precisely implanted in many different target tissues without the need for invasive surgery. Moreover, similar to the radiation emitted from conventional brachytherapy seeds, the therapeutically active substance included within a seed can be delivered in a controlled fashion over a relatively long period of time (e.g., weeks, months, or longer periods).
PCT/US2001/043517 2000-11-16 2001-11-16 Polymeric imagable brachytherapy seed Ceased WO2002068000A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001297657A AU2001297657A1 (en) 2000-11-16 2001-11-16 Polymeric imagable brachytherapy seed
EP01273840A EP1372742A2 (en) 2000-11-16 2001-11-16 Polymeric imagable brachytherapy seed

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US24912800P 2000-11-16 2000-11-16
US60/249,128 2000-11-16
US09/861,326 2001-05-18
US09/861,326 US6746661B2 (en) 2000-11-16 2001-05-18 Brachytherapy seed
US09/861,196 US6514193B2 (en) 2000-11-16 2001-05-18 Method of administering a therapeutically active substance
US09/861,196 2001-05-18

Publications (2)

Publication Number Publication Date
WO2002068000A2 WO2002068000A2 (en) 2002-09-06
WO2002068000A3 true WO2002068000A3 (en) 2003-10-23

Family

ID=27400179

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/043517 Ceased WO2002068000A2 (en) 2000-11-16 2001-11-16 Polymeric imagable brachytherapy seed

Country Status (3)

Country Link
EP (1) EP1372742A2 (en)
AU (1) AU2001297657A1 (en)
WO (1) WO2002068000A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003267309A1 (en) 2000-11-16 2004-04-08 Microspherix Llc Flexible and/or elastic brachytherapy seed or strand
CN102470184B (en) 2009-08-06 2017-05-31 皇家飞利浦电子股份有限公司 Tumor treatment with radioactive seeds
JP7232489B2 (en) 2017-05-11 2023-03-03 アルファ タウ メディカル リミテッド Polymer coating for brachytherapy devices
EP3773896A4 (en) * 2018-04-02 2022-01-12 Alpha TAU Medical Ltd. CONTROLLED RELEASE OF RADIONUKLIDES
AU2021400142B2 (en) 2020-12-16 2024-11-21 Alpha Tau Medical Ltd. Diffusing alpha-emitters radiation therapy with enhanced beta treatment

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003036A1 (en) * 1993-07-19 1995-02-02 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
WO1996014880A1 (en) * 1994-11-16 1996-05-23 Pgk, Enterprises, Inc. Method and apparatus for interstitial radiation of the prostate gland
US5886026A (en) * 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
WO2000032238A1 (en) * 1998-12-03 2000-06-08 Scimed Life Systems, Inc. Stent having drug crystals thereon
WO2000041185A1 (en) * 1999-01-07 2000-07-13 Nycomed Amersham Plc Improved brachytherapy seeds
WO2000043045A1 (en) * 1999-01-25 2000-07-27 Photogen, Inc. Method for improved radiation therapy
WO2000051639A2 (en) * 1999-03-01 2000-09-08 Halogenetics, Inc. Treatment of neoplastic diseases by radiation
WO2000057923A2 (en) * 1999-03-29 2000-10-05 North American Scientific, Inc. Radioactive seed with multiple markers and method for using same
WO2001036007A2 (en) * 1999-11-12 2001-05-25 Angiotech Pharmaceuticals, Inc. Compositions of a combination of radioactive therapy and cell-cycle inhibitors
WO2002030472A2 (en) * 2000-10-12 2002-04-18 Guilford Pharmaceuticals, Inc. Compositions for release of radiosensitizers, and methods of making and using the same

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003036A1 (en) * 1993-07-19 1995-02-02 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
US5886026A (en) * 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
US20030003094A1 (en) * 1993-07-19 2003-01-02 Hunter William L. Anti-angiogenic compositions and methods of use
WO1996014880A1 (en) * 1994-11-16 1996-05-23 Pgk, Enterprises, Inc. Method and apparatus for interstitial radiation of the prostate gland
WO2000032238A1 (en) * 1998-12-03 2000-06-08 Scimed Life Systems, Inc. Stent having drug crystals thereon
WO2000041185A1 (en) * 1999-01-07 2000-07-13 Nycomed Amersham Plc Improved brachytherapy seeds
WO2000043045A1 (en) * 1999-01-25 2000-07-27 Photogen, Inc. Method for improved radiation therapy
WO2000051639A2 (en) * 1999-03-01 2000-09-08 Halogenetics, Inc. Treatment of neoplastic diseases by radiation
WO2000057923A2 (en) * 1999-03-29 2000-10-05 North American Scientific, Inc. Radioactive seed with multiple markers and method for using same
WO2001036007A2 (en) * 1999-11-12 2001-05-25 Angiotech Pharmaceuticals, Inc. Compositions of a combination of radioactive therapy and cell-cycle inhibitors
US20020055666A1 (en) * 1999-11-12 2002-05-09 Hunter William L. Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors
WO2002030472A2 (en) * 2000-10-12 2002-04-18 Guilford Pharmaceuticals, Inc. Compositions for release of radiosensitizers, and methods of making and using the same

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
37TH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR THERAPEUTIC RADIOLOGY AND ONCOLOGY, 8 October 1995 (1995-10-08), MIAMI BEACH, FLORIDA, USA *
DOIRON A ET AL: "TUMOR RADIOSENSITIZATION BY SUSTAINED INTRATUMORAL RELEASE OF BROMODEOXYURIDINE", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, no. 15, 1 August 1999 (1999-08-01), pages 3677 - 3681, XP001094937, ISSN: 0008-5472 *
HORIUCHI J ET AL: "RADIO THERAPY FOR CARCINOMA OF THE TONGUE WITH SPECIAL EMPHASIS ON THE ADVANCED CASES", JOURNAL OF JAPAN SOCIETY FOR CANCER THERAPY, vol. 15, no. 5, 1980, pages 851 - 857, XP008016950, ISSN: 0021-4671 *
PRESTIDGE BRADLEY R ET AL: "Post-treatment biopsy results following permanent transrectal ultrasound-guided interstitial brachytherapy in early stage prostate cancer.", INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol. 32, no. SUPPL. 1, 1995, pages 144, XP002249972, ISSN: 0360-3016 *
SEE WILLIAM A ET AL: "Brachytherapy and continuous infusion 5-fluorouracil for the treatment of locally advanced, lymph node negative, prostate cancer: A phase I trial.", CANCER, vol. 77, no. 5, 1996, pages 924 - 927, XP008016945, ISSN: 0008-543X *
YAPP D T T ET AL: "RADIOSENSITIZATION OF A MOUSE TUMOR MODEL BY SUSTAINED INTRA-TUMORAL RELEASEOF ETANIDAZOLE AND TIRAPAZAMINE USING A BIODEGRADABLE POLYMER IMPLANT DEVICE", RADIOTHERAPY AND ONCOLOGY, AMSTERDAM, NL, vol. 53, no. 1, October 1999 (1999-10-01), pages 77 - 84, XP001094931 *

Also Published As

Publication number Publication date
WO2002068000A2 (en) 2002-09-06
AU2001297657A1 (en) 2002-09-12
EP1372742A2 (en) 2004-01-02

Similar Documents

Publication Publication Date Title
US20030225437A1 (en) Device for retaining material
US20230165605A1 (en) Deformable body and combination of such deformable body and a surgical screw element
US9289625B2 (en) Brachytherapy seed with fast dissolving matrix for optimal delivery of radionuclides to cancer tissue
JP2011139935A (en) Brachytherapy method and applicator for treatment of metastatic lesion in load bearing region
KR100228188B1 (en) Radioactive stents and a method of manufacturing the same
US20020177748A1 (en) Brachytherapy systems and methods
DE60142332D1 (en) CATHETER SYSTEM FOR INTRODUCING AN IMPLANT
BR0205990A (en) An implantable one-way delivery system for therapeutic tissue agents
MX9700850A (en) FORMULATIONS AND METHODS TO PROVIDE PROLONGED LOCAL ANESTHESIA.
EP1982695A3 (en) Manufacture of long term drug delivery devices with polyurethane
JP2007535334A (en) Seed and spacer placement for brachytherapy
EP3189795A3 (en) Brachytherapy clip and applicator
US6120540A (en) Radio prosthesis
US20240342505A1 (en) Radiation shielding apparatus for implantable radioactive seeds
WO2005023367A3 (en) X-ray and gamma ray emitting temporary high dose rate brachyterapy source
US7029431B2 (en) Directional-ionizing energy emitting implant
WO2002068000A3 (en) Polymeric imagable brachytherapy seed
JPS59500798A (en) surgical aids
US20100056843A1 (en) Brachytherapy Seed With Fast Dissolving Matrix for Optimal Delivery of Radionuclides To Cancer Tissue
RU98101941A (en) METHOD FOR COMBATING DISEASES OF GRAIN CROPS
ES2230396T3 (en) DEVICE FOR COVERING AN OBJECT WITH AN ACTIVE PRINCIPLE AND PROCEDURE FOR MANUFACTURE OF A PARTIAL OR TOTAL COATING OF THE ACTIVE PRINCIPLE ON OR IN IMPLANTS OR INSERTS AS WELL AS USE OF THE PROCEDURE AND PRODUCT MANUFACTURED THROUGH THE PROCEDURE.
US20240238457A1 (en) Gel Loaded with Alpha-Emitter Radionuclides
SCALLON et al. Permanent interstitial therapy using low energy and long half-life radiation sources
Mondalek et al. A clinical telescoping intraoperative electron radiation therapy device
Wessels et al. Direct verification of absorbed dose for tumor associated radioimmunotherapy

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US US US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2001273840

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2001273840

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP