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WO2002064620A3 - Metal-binding compounds and uses therefor - Google Patents

Metal-binding compounds and uses therefor Download PDF

Info

Publication number
WO2002064620A3
WO2002064620A3 PCT/US2002/004275 US0204275W WO02064620A3 WO 2002064620 A3 WO2002064620 A3 WO 2002064620A3 US 0204275 W US0204275 W US 0204275W WO 02064620 A3 WO02064620 A3 WO 02064620A3
Authority
WO
WIPO (PCT)
Prior art keywords
metal
binding compounds
animal
reducing
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/004275
Other languages
French (fr)
Other versions
WO2002064620A2 (en
Inventor
David Bar-Or
C Gerald Curtis
Edward Lau
Nagaraja K R Rao
James V Winkler
Wannell M Crook
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DMI Biosciences Inc
Original Assignee
DMI Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DMI Biosciences Inc filed Critical DMI Biosciences Inc
Priority to AU2002255540A priority Critical patent/AU2002255540A1/en
Publication of WO2002064620A2 publication Critical patent/WO2002064620A2/en
Anticipated expiration legal-status Critical
Publication of WO2002064620A3 publication Critical patent/WO2002064620A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides a method of reducing the damage done by reactive oxygen species (ROS) in an animal. The invention also provides a method of reducing the concentration of a metal in an animal. These methods comprise administering to the animal an effective amount of a metal-binding compounds as further described in the application. The invention further provides a method of reducing the damage done by ROS to a cell, a tissue or an organ that has been removed from an animal. This method comprising contacting the cell, tissue or organ with a solution or medium containing an effective amount of a metal-binding compound of the invention. The invention further provides novel metal-binding compounds, pharmaceutical compositions comprising the metal-binding compounds, and kits comprising a container holding a metal-binding compound of the invention.
PCT/US2002/004275 2001-02-13 2002-02-13 Metal-binding compounds and uses therefor Ceased WO2002064620A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002255540A AU2002255540A1 (en) 2001-02-13 2002-02-13 Metal-binding compounds and uses therefor

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US26855801P 2001-02-13 2001-02-13
US60/268,558 2001-02-13
US81667901A 2001-03-22 2001-03-22
US09/816,679 2001-03-22
US28164801P 2001-04-04 2001-04-04
US60/281,648 2001-04-04
US28350701P 2001-04-11 2001-04-11
US60/283,507 2001-04-11

Publications (2)

Publication Number Publication Date
WO2002064620A2 WO2002064620A2 (en) 2002-08-22
WO2002064620A3 true WO2002064620A3 (en) 2003-08-14

Family

ID=27500944

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/004275 Ceased WO2002064620A2 (en) 2001-02-13 2002-02-13 Metal-binding compounds and uses therefor

Country Status (2)

Country Link
AU (1) AU2002255540A1 (en)
WO (1) WO2002064620A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002323368B2 (en) 2001-08-23 2006-12-07 The Government Of The United States Of America As Represented By The Secretary, Department Of Health & Human Services Methods of inhibiting formation of vascular channels and profileration using pyridinone derivatives
NZ547077A (en) * 2001-11-20 2008-04-30 Dmi Biosciences Inc An oral product comprising an amount of a metal-binding peptide which is effective for oral care
CN102266272B (en) 2002-11-27 2012-12-26 Dmi生物科学公司 Personal care composition and products

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5538945A (en) * 1994-06-17 1996-07-23 Procyte Corporation Stimulation of hair growth by peptide copper complexes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5538945A (en) * 1994-06-17 1996-07-23 Procyte Corporation Stimulation of hair growth by peptide copper complexes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BATTEGAY E.J.: "Angiogenesis: Mechanistic insights, neovascular diseases and therapeutic prospects", JOURNAL OF MOLECULAR MEDICINE, vol. 73, 1995, pages 333 - 346, XP002913098 *

Also Published As

Publication number Publication date
AU2002255540A1 (en) 2002-08-28
WO2002064620A2 (en) 2002-08-22

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