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WO2002062803A1 - Thienopyrimidine derivative - Google Patents

Thienopyrimidine derivative Download PDF

Info

Publication number
WO2002062803A1
WO2002062803A1 PCT/JP2002/001008 JP0201008W WO02062803A1 WO 2002062803 A1 WO2002062803 A1 WO 2002062803A1 JP 0201008 W JP0201008 W JP 0201008W WO 02062803 A1 WO02062803 A1 WO 02062803A1
Authority
WO
WIPO (PCT)
Prior art keywords
thienopyrimidine derivative
derivative
thienopyrimidine
medicine
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2002/001008
Other languages
French (fr)
Japanese (ja)
Inventor
Hirotsune Itahana
Takashi Kamikubo
Eisuke Nozawa
Hidetaka Kaku
Masamichi Okada
Takashi Toya
Atsushi Nakamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of WO2002062803A1 publication Critical patent/WO2002062803A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A novel thienopyrimidine derivative or a salt thereof. The compound has metabotropic glutamate receptor activity and is useful as a medicine.
PCT/JP2002/001008 2001-02-08 2002-02-07 Thienopyrimidine derivative Ceased WO2002062803A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001032121 2001-02-08
JP2001-32121 2001-02-08

Publications (1)

Publication Number Publication Date
WO2002062803A1 true WO2002062803A1 (en) 2002-08-15

Family

ID=18896101

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/001008 Ceased WO2002062803A1 (en) 2001-02-08 2002-02-07 Thienopyrimidine derivative

Country Status (1)

Country Link
WO (1) WO2002062803A1 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004029060A1 (en) * 2002-09-26 2004-04-08 Nihon Nohyaku Co., Ltd. Novel herbicides, usage thereof, novel thienopyrimidine derivatives, intermediates of the same, and process for production thereof
WO2006002051A1 (en) * 2004-06-15 2006-01-05 Schering Corporation Tricyclic compounds and their use as mglur1 antagonists
WO2007024593A1 (en) * 2005-08-19 2007-03-01 Schering Corporation Fused tricyclic mglur1 antagonists as therapeutic agents
WO2007072090A1 (en) * 2005-12-20 2007-06-28 Richter Gedeon Nyrt. Thienopyridine derivatives as modulators of metabotropic glutamate receptors
US7482360B2 (en) 2005-09-23 2009-01-27 Schering Corporation Fused tetracyclic mGluR1 antagonists as therapeutic agents
US7598259B2 (en) 2004-06-15 2009-10-06 Schering Corporation mGluR1 antagonists as therapeutic agents
US7939657B2 (en) * 2003-10-29 2011-05-10 Elan Pharmaceuticals, Inc. N-substituted benzene sulfonamides
US8691833B2 (en) 2007-02-23 2014-04-08 Merck Sharp & Dohme Corp. Heterocyclic aspartyl protease inhibitors
WO2015056771A1 (en) 2013-10-17 2015-04-23 アステラス製薬株式会社 Sulfur-containing bicyclic compound

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006724A1 (en) * 1996-08-09 1998-02-19 Yamanouchi Pharmaceutical Co., Ltd. Metabotropic glutamate receptor agonists
JPH11189596A (en) * 1997-12-25 1999-07-13 Yamanouchi Pharmaceut Co Ltd Metabotropic glutamate receptor agonist and new imidazobenzothiazole derivative
WO2000059913A1 (en) * 1999-04-06 2000-10-12 Yamanouchi Pharmaceutical Co., Ltd. Novel thiazolobenzimidazole derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998006724A1 (en) * 1996-08-09 1998-02-19 Yamanouchi Pharmaceutical Co., Ltd. Metabotropic glutamate receptor agonists
JPH11189596A (en) * 1997-12-25 1999-07-13 Yamanouchi Pharmaceut Co Ltd Metabotropic glutamate receptor agonist and new imidazobenzothiazole derivative
WO2000059913A1 (en) * 1999-04-06 2000-10-12 Yamanouchi Pharmaceutical Co., Ltd. Novel thiazolobenzimidazole derivatives

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004029060A1 (en) * 2002-09-26 2004-04-08 Nihon Nohyaku Co., Ltd. Novel herbicides, usage thereof, novel thienopyrimidine derivatives, intermediates of the same, and process for production thereof
US7939657B2 (en) * 2003-10-29 2011-05-10 Elan Pharmaceuticals, Inc. N-substituted benzene sulfonamides
WO2006002051A1 (en) * 2004-06-15 2006-01-05 Schering Corporation Tricyclic compounds and their use as mglur1 antagonists
US7989464B2 (en) 2004-06-15 2011-08-02 Schering Corporation mGluR1 antagonists as therapeutic agents
US7485648B2 (en) 2004-06-15 2009-02-03 Schering Corporation mGluR1 antagonists as therapeutic agents
US7598259B2 (en) 2004-06-15 2009-10-06 Schering Corporation mGluR1 antagonists as therapeutic agents
WO2007024593A1 (en) * 2005-08-19 2007-03-01 Schering Corporation Fused tricyclic mglur1 antagonists as therapeutic agents
US7767815B2 (en) 2005-08-19 2010-08-03 Schering Corporation Fused tricyclic mGluR1 antagonists as therapeutic agents
US7482360B2 (en) 2005-09-23 2009-01-27 Schering Corporation Fused tetracyclic mGluR1 antagonists as therapeutic agents
WO2007072090A1 (en) * 2005-12-20 2007-06-28 Richter Gedeon Nyrt. Thienopyridine derivatives as modulators of metabotropic glutamate receptors
US8691833B2 (en) 2007-02-23 2014-04-08 Merck Sharp & Dohme Corp. Heterocyclic aspartyl protease inhibitors
US8691831B2 (en) 2007-02-23 2014-04-08 Merck Sharp & Dohme Corp. Heterocyclic aspartyl protease inhibitors
WO2015056771A1 (en) 2013-10-17 2015-04-23 アステラス製薬株式会社 Sulfur-containing bicyclic compound
US9051339B2 (en) 2013-10-17 2015-06-09 Astellas Pharma Inc. Sulfur-containing bicyclic compound
CN105636965A (en) * 2013-10-17 2016-06-01 安斯泰来制药株式会社 Sulfur-containing bicyclic compound
KR20160071408A (en) 2013-10-17 2016-06-21 아스텔라스세이야쿠 가부시키가이샤 Sulfur-containing bicyclic compound
US9642852B2 (en) 2013-10-17 2017-05-09 Astellas Pharma Inc. Sulfur-containing bicyclic compound
CN105636965B (en) * 2013-10-17 2017-11-24 安斯泰来制药株式会社 The ring type compound of sulfur-bearing two
EA029075B1 (en) * 2013-10-17 2018-02-28 Астеллас Фарма Инк. Sulfur-containing bicyclic compound

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