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WO2002048384A3 - Sequence d'acide nucleique « m73791 » utilisee comme gene humain et ses derives - Google Patents

Sequence d'acide nucleique « m73791 » utilisee comme gene humain et ses derives Download PDF

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Publication number
WO2002048384A3
WO2002048384A3 PCT/DE2001/004771 DE0104771W WO0248384A3 WO 2002048384 A3 WO2002048384 A3 WO 2002048384A3 DE 0104771 W DE0104771 W DE 0104771W WO 0248384 A3 WO0248384 A3 WO 0248384A3
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WIPO (PCT)
Prior art keywords
nucleic acid
enclosure
chromosome
acid sequence
derivatives
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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PCT/DE2001/004771
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German (de)
English (en)
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WO2002048384A2 (fr
Inventor
Marianne Kroepelin
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Individual
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Individual
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Publication of WO2002048384A2 publication Critical patent/WO2002048384A2/fr
Publication of WO2002048384A3 publication Critical patent/WO2002048384A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne la séquence d'acide nucléique M73791 (ADNc), présente dans des cellules humaines saines et malignes. La séquence M73791 (annexe 1) ou des parties de ladite séquence peuvent se trouver en orientation positive 5'-3' et/ou en orientation négative 3'-5'. L'ADN fortement conservé, à base de 722 paires de base (bp) est localisé à 100 % sur la section q28 du chromosome X dans la zone du gène FLNA/G6DH (annexe 2), et à 98 % sur le chromosome 19 (annexe 3). L'ADN M73791 transduit comprend 214 acides aminés et se trouve à l'extrémité C-terminale d'une séquence peptidique déterminée par « genscan » sur le chromosome X, ladite séquence peptidique étant identique à la « protéine QM » et à RPL10 (annexe 4). La séquence d'acide nucléique décrite dans ce titre de propriété industrielle est transcrite de manière différenciée dans des tissus de différentes origines. Suite à des mutations, telles que des délétions, des insertions ou des substitutions, des variantes interviennent (annexe 5 à 8). L'utilisation tissulaire de M73791 et de ses dérivés qui contiennent également des oligonucléotides à « polymorphisme nucléotidique simple » (SNPs) intervient sous forme de substance d'essai dans des dosages biologiques d'acide nucléique et de dosages immunologiques à des fins diagnostiques et comme matière effectrice pour moduler la transcription et l'expression de gènes.
PCT/DE2001/004771 2000-12-13 2001-12-13 Sequence d'acide nucleique « m73791 » utilisee comme gene humain et ses derives Ceased WO2002048384A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2000161931 DE10061931A1 (de) 2000-12-13 2000-12-13 Nukleinsäuresequenz "M73791" als humanes Gen und deren Derivate, sowie deren Transkriptions- und Translationsprodukte, zur kommerziellen Verwendung in Diagnostik und Therapie
DE10061931.2 2000-12-13

Publications (2)

Publication Number Publication Date
WO2002048384A2 WO2002048384A2 (fr) 2002-06-20
WO2002048384A3 true WO2002048384A3 (fr) 2002-12-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2001/004771 Ceased WO2002048384A2 (fr) 2000-12-13 2001-12-13 Sequence d'acide nucleique « m73791 » utilisee comme gene humain et ses derives

Country Status (2)

Country Link
DE (1) DE10061931A1 (fr)
WO (1) WO2002048384A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583210A (en) * 1993-03-18 1996-12-10 Pioneer Hi-Bred International, Inc. Methods and compositions for controlling plant development
WO2001075067A2 (fr) * 2000-03-31 2001-10-11 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583210A (en) * 1993-03-18 1996-12-10 Pioneer Hi-Bred International, Inc. Methods and compositions for controlling plant development
WO2001075067A2 (fr) * 2000-03-31 2001-10-11 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 29 September 2000 (2000-09-29), SUGANO S. ET AL., XP002206063, retrieved from EBI Database accession no. AK026568 *
DATABASE EMBL [online] 30 April 1991 (1991-04-30), DOWDY S.F.: "Human Wilm's tumor-related protein (QM) mRNA, complete cds", XP002206062, retrieved from EBI Database accession no. M64241 *
DATABASE EMBL [online] KROEPELIN M: "Sequence analysis of a novel gene expressed in normal and in tumor-derived tissue", XP002206061, retrieved from EBI Database accession no. M73791 *
DATABASE GENESEQ [online] 18 February 2002 (2002-02-18), "Novel human diagnostic protein 12172", XP002206064, retrieved from EBI Database accession no. abg12181 *

Also Published As

Publication number Publication date
DE10061931A1 (de) 2001-09-06
WO2002048384A2 (fr) 2002-06-20

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