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WO2001028682A1 - Systeme electromagnetique pour la manipulation de fluides - Google Patents

Systeme electromagnetique pour la manipulation de fluides Download PDF

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Publication number
WO2001028682A1
WO2001028682A1 PCT/ES2000/000383 ES0000383W WO0128682A1 WO 2001028682 A1 WO2001028682 A1 WO 2001028682A1 ES 0000383 W ES0000383 W ES 0000383W WO 0128682 A1 WO0128682 A1 WO 0128682A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
membrane
technology
fluids
electromagnets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ES2000/000383
Other languages
English (en)
Spanish (es)
Inventor
Antonio Ivorra Cano
Ivan Erill Sagales
Abdelhamid Errachid
Jordi Aguilo Lobet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Priority to AU77908/00A priority Critical patent/AU7790800A/en
Publication of WO2001028682A1 publication Critical patent/WO2001028682A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G01N2035/00247—Microvalves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves

Definitions

  • Electromagnetic system for fluid handling.
  • the present invention allows to create iiistrumentation applicable to chemical analysis and chemical synthesis.
  • the proposed technology allows the realization of systems formed by a reading device, which in certain applications will simply act as a controller, and a card or cartridge that will be inserted into said equipment.
  • the cartridge has a series of ducts and cavities constructed from a laminar structure. One or several areas are covered with an elastic membrane that in turn contains various areas with ferromagnetic material or permanent magnets.
  • the reader has a set of electromagnets that are activated from an electronic system when the cartridge is inserted. These electromagnets are arranged so that they act selectively on each of the magnetic areas, causing deformations at specific points of the elastic membrane.
  • valves or suction pumps allowing the circulation of fluids inside the cartridge, the suction of external fluids, or the expulsion of fluids outwards.
  • a typical application of the system will be the realization of portable equipment that allows the analysis of fluids by electronic sensors and requires a process of calibration or previous preparation of the sample.
  • the system is a simple, economical and compact alternative to existing ⁇ -TAS systems. In addition, it allows the manipulation of moderate volumes and unpurified liquids (eg blood).
  • FIGS 1, 2, 3 and 4 allow to understand the construction and operation of the basic elements of this technology.
  • the system of deposits and conduction channels is formed from holes and incisions made in the intermediate plate (2).
  • Figure 3 shows a top and bottom view of the plate.
  • the plates (2) and (3) will preferably be constructed with rigid materials
  • the intermediate plate (2) can be manufactured from a uniform plate by a machining process or by a chemical attack after a photolithographic process. It is also possible to resort to the injection of the material (plastic) into a mold.
  • the number and size of internal deposits and channels can be increased if intermediate layers are added and, in this way, there will be different channel heights with which these can be crossed.
  • the use of multiple layers can also be used to simplify the manufacturing process. If the upper channels are made on the lower surface of the upper plate it will only be necessary to work one of the surfaces of each layer. It is possible to construct the ducts from longitudinal cuts in the plate when it is limited by an upper and a lower plate. This method can be useful when precision is required in the duct section.
  • Structures equivalent to the proposal can be made by accumulating different layers of material, avoiding the process of joining between plates.
  • the material of the different layers is photocurable, the formation of ducts will be carried out by a photolithographic process after curing the lower layers.
  • the existence of one or several membranes of elastic material is one of the key elements in the operation of the structure.
  • the elastic layer (1) completely covers the upper surface of the cartridge and is fixed to the intermediate plate (2) by means of an adhesive, an adherent sheet on both sides or by welding between both materials. Fixing should not be done on the entire surface.
  • the membrane In certain areas (14, 15 and 16) the membrane must be able to separate and, therefore, there must be no connection with the intermediate plate (2).
  • Figure 4 shows a possible pattern of union between the membrane and the plate, in the areas (14, 15 and 16) the membrane is free. In the case that a sheet of adherent material is used, this figure would correspond to its appearance.
  • the membrane will separate from the intermediate plate due to tensile forces in the presence of sufficiently strong magnetic fields. This is achieved by fixing ferromagnetic material (6, 7 and 8) on the membrane.
  • ferromagnetic material (6, 7 and 8) on the membrane.
  • Some solutions are: material introduction ferromagnetic in the composition of the membrane, fixation by means of adhesive plates of ferromagnetic material (Fe-Ni alloys) and deposition of filings of ferromagnetic material and subsequent covering with a material that allows the movement of the membrane.
  • the cores of a set of electromagnets, belonging to the reading equipment are located a short distance from the active elements of the cartridge (valves and pumps).
  • the tanks (12 and 13) are insulated by the valves (14 and 15), note that the flexible membrane obstructs the ducts ( Figure 2).
  • the pumping process begins by opening the valve (14), for this it is necessary that the reading equipment apply a sufficient current to the electromagnet (9), so that the lower ferromagnetic material (6) forces the lifting of the elastic membrane and the duct is no longer clogged
  • the membrane will be lifted in the area (15) by applying current in the electromagnet (10). This fact will cause the suction of the fluid, initially air, through the channel (17).
  • the valve (14) will be closed, stop applying current on (9): the elasticity of the membrane will perform this work.
  • the valve (16) will open and no more current will be applied to (10), whereby the fluid will be pushed to the reservoir (13) through the conduit (18). Finally, the valve (16) will be closed and a new cycle will be started if necessary.
  • the flow is discrete, in each cycle a fixed amount of fluid is transferred.
  • the amount transferred depends on the volume that forms when the membrane rises in the area (15), if it is possible to narrow the survey, it is possible to limit this volume.
  • the height stop may be the core of the electromagnet, but, also, an intermediate plate can be placed attached to the cartridge at its ends.
  • valve (16) is not absolutely necessary in the scheme proposed In the described components, ferromagnetic material without permanent magnetization is used as a magnetic field sensitive material.
  • the use of permanent magnets is a more expensive and complex alternative but requires lower excitation currents and allows the 'active' closing of the valves: with the proper polarity of current, the electromagnet will push the elastic membrane towards the plate.
  • the shape of the cartridge in this case is flat, similar to a card, but there is the possibility of adopting other geometries using the processes and elements that have been described.
  • valves as selector devices. In this case, the valves remain fully open or closed for a relatively long period of time. If these same valves are activated by short pulses, it is possible to partially restrict fluid circulation.
  • the sensors may be external, that is, they will be part of the structure of the reader but not of the cartridge.
  • optical sensors These are capable of providing many important parameters: absorption spectrum, reflection spectrum, attenuation ... It will be interesting to obtain optical parameters of the fluid in certain cavities of the cartridge, for example: the fluid to be analyzed will be mixed with a reagent and the resulting color will determine the degree of presence of a specific chemical species To obtain this information with external sensors, some areas will be created in the cartridge that allow the passage of light, without significant losses, in the spectral region of interest.
  • Figure 8 corresponds to a sectional cut of a possible optical window, in which the fluid is It is limited by two transparent plates, (43 and 44). schematize the related devices in the light source reader equipment (39), converging lenses (40) and sensor (41)
  • the liquid to be analyzed is absorbed by the duct (34 ) thanks to the suction created by the pump formed with the elements (23, 24 and 25)
  • the expulsion of fluids occurs through the duct (35) after leaving the valve (25)
  • This fluid can be air that will empty chamber and ducts, calibration liquid to calibrate ISFETs periodically, or liquid to be analyzed
  • the components are mounted on a printed circuit board (31) that will adapt as an intermediate layer, as described in the previous section. Part of this board will be used as a connector (28)
  • FIG. 9 presents a general scheme of the circuitry and components of the reader equipment
  • the electromagnets (49) are excited from a control circuit (48) that responds to the orders of the microcontroller (microprocessor)
  • the sequence of orders will follow a program stored in memory and, in certain cases, it may be modified depending on some events, keyboard press, end of the measurement, command from external equipment
  • the data represented in the viewer will correspond to the information obtained through the internal detectors of the card or through external systems ( 50) (optical system)
  • the signals are extracted from the cartridge through the connector (54) It is also possible to introduce signals or power currents into the card with the same connector
  • the number of electromagnets (49) and optical windows (50) shown in the figure is not significant, it depends on the structure of the cartridge.
  • the power supply can be provided by any of the usual methods in electronics: batteries, rechargeable batteries, mains adapter ... (The option of rechargeable batteries is especially interesting in portable equipment.)
  • Figure 10 shows the possible external appearance of the reading equipment.
  • conduits, cavities, tanks, pumps, valves, optical windows and electronic components The methodology to integrate different components in rigid substrate has been described: conduits, cavities, tanks, pumps, valves, optical windows and electronic components. From these elements, it is possible to build a wide range of analysis and synthesis systems without this involving inventive activity. In fact, it would be enough to imitate the FIA (flow injection analysis) systems that are currently carried out from discrete components.
  • FIA flow injection analysis
  • Figure 1 External appearance of a cartridge that allows the transfer of liquids between two internal tanks. It is constructed with two plates of rigid material (2 and 3) and a membrane of elastic material (1). The ferromagnetic elements (6, 7 and 8) are fixed to the membrane. The holes (4 and 5) allow the entry and exit of air.
  • Figure 2 Longitudinal section of the cartridge in the axis formed by the pump elements (14, 15 and 16).
  • the valves (14 and 16) allow the circulation of the fluid through the channels (17 and 18) when sufficient current flows through the corresponding electromagnets (9 and 11).
  • the suction / compression element is activated by the central electromagnet (10).
  • Figure 3 Appearance of the intermediate plate (2, in the previous figures) in a top view (left) and a lower view (right).
  • Figure 4 Joint pattern between the flexible membrane and the intermediate plate.
  • Figure 5 External appearance of a cartridge that includes electronic components (38) in the circulation duct. Fluid (26) enters the cartridge through the conduit (34) due to the suction caused by the pump (23, 24 and 25) when the corresponding valve (22) is open. The fluid is expelled (27) through the conduit (35).
  • the valves (22, 21 and 20) select the fluid that circulates through the card: external fluid, internal fluid (reservoir 36) or air (19)
  • the printed circuit board (31), on which the components are located, has a connector (28)
  • Figure 6 Longitudinal section of the cartridge of Figure 5 by the axis formed by the elements (22, 23, 24 and 25)
  • the adapter (37) allows the connection of the external ducts (34 and 35)
  • Figure 7 Fluidic diagram of the structure of the cartridge of figure 5
  • Figure 8 Cut of the longitudinal section of an optical window
  • the radiation from the light source (39) passes through the chamber in which the fluid is located (45) and is led to the sensor element (41)
  • Transparent sheets (43 and 44) do not prevent the circulation of radiation in the spectral regions of interest
  • FIG 9 Electrical block diagram of the reader equipment
  • the microcontroller follows a program stored in memory to activate the electromagnets (49) by means of a control circuit (48)
  • the cartridge detectors (55) provide information to the microcontroller through the connector (54) , after conditioning the signals (47) Also, information can be obtained through optical systems (50)
  • the equipment can be connected to external elements through communications interfaces (52 and 53)
  • Figure 10 External appearance of a portable reader equipment The cartridge is inserted into the groove (56)
  • FIG. 1 An illustrative example is that of Figures 1, 2, 3 and 4
  • the cartridge has been made with two transparent methacrylate plates of 70 mm by 40 mm and thicknesses of 5 mm and 10 mm The union between them is done by means of an adhesive.
  • intermediate plate (2) has been machined from the original plate
  • the width and depth of all the channels is 1 mm and the height of the protuberances (valves 14 and 16) is 1 mm
  • the tanks (12 and 13) are cylindrical and its diameter is 10 mm
  • the air inlet (4) and air outlet (5) have a diameter of 2 mm
  • the elastic membrane is a sheet of latex with 0.2 mm thickness
  • the fixation to the intermediate plate (2) has been made by a thin sheet of adhesive material on both sides. This sheet has been previously cut according to the pattern in figure 4
  • the material of the ferromagnetic elements is the same as that found in the mobile element of the commercial relays (Fe-Ni alloy). Squares of 4 have been obtained. mm side and 0.8 mm thick by machining a uniform Fe-Ni plate (circumferences are shown in the figure) These squares have been fixed to the membrane by means of an adhesive
  • the reader equipment, controller in this case has a structure made of methacrylate that is placed on the cartridge and places the cores of the electromagnets at 1.5 mm from the ferromagnetic elements
  • the electromagnets have been extracted from 52 ⁇ commercial relays
  • the excitation of the electromagnets is carried out with currents of 150 ⁇ A following the sequence previously described (the time between operations of a cycle is 0.2 seconds, so the total cycle duration is 1.2 sec)
  • the currents are injected by an electronic circuit controlled by a computer through its parallel port
  • FIG. 5 A second example is shown in Figures 5, 6 and 7
  • the cartridge measurements are 120 mm by 70 mm.
  • the rigid top plate (30) has a thickness of 10 mm, the printed circuit (32) 1 mm; the bottom plate (32) 5mm; and the closure (33) 5mm.
  • the calibration solution tank (36) is a 20mm diameter and 20mm high cylinder made of PVC and connected in its lower part to the valve (21).
  • the inlet (34) and outlet ducts (35) are Teflon tubes with external diameter of lmm, the connection to the cartridge has been made using silicone.
  • the control equipment is equivalent to the previous one, it only differs in the dimensions due to the inclusion of three more electromagnets.
  • the electronic components that are placed in the internal chamber (38) are a reference electrode and an ISFET (pH sensitive semiconductor device)
  • the external connectors (28) are connected to an ISFETometer that passes the data obtained to the computer through a port of communications
  • This same computer presents the data on the screen, after processing, and is responsible for controlling the electromagnets.
  • the sample (26) circulates through the chamber with sensors (38), but periodically a small amount of calibration liquid is circulated to fix a point on the line that relates pH to the measurement obtained by the ISFETometer, that is, it helps to the computer to provide a correct value.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne une technologie permettant la réalisation de systèmes pourvus d'un équipement lecteur qui sert simplement de contrôleur dans certaines applications et une carte ou cartouche introduite dans ledit équipement. La cartouche présente une série de conduits et de cavités obtenus à partir d'une structure lamellaire. Une ou plusieurs zone(s) est(sont) couverte(s) d'une membrane élastique qui comprend, à son tour, différentes zones avec un matériau ferromagnétique ou des aimants permanents. Le lecteur possède un ensemble d'électro-aimants qui sont actionnés par un système électronique lors de l'insertion de la cartouche. Ces électro-aimants sont disposés de manière à agir sélectivement sur chaque zone magnétique, entraînant des déformations en des points concrets de la membrane élastique. Ces points servent de soupapes ou pompes d'aspiration, permettant ainsi la circulation de fluides dans la cartouche, l'aspiration de fluides externes ou l'expulsion de fluides vers l'extérieur.
PCT/ES2000/000383 1999-10-15 2000-10-06 Systeme electromagnetique pour la manipulation de fluides Ceased WO2001028682A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU77908/00A AU7790800A (en) 1999-10-15 2000-10-06 Electromagnetic system for manipulating fluids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP9902277 1999-10-15
ES9902277A ES2158808B1 (es) 1999-10-15 1999-10-15 Sistema electromagnetico para la manipulacion de fluidos.

Publications (1)

Publication Number Publication Date
WO2001028682A1 true WO2001028682A1 (fr) 2001-04-26

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PCT/ES2000/000383 Ceased WO2001028682A1 (fr) 1999-10-15 2000-10-06 Systeme electromagnetique pour la manipulation de fluides

Country Status (3)

Country Link
AU (1) AU7790800A (fr)
ES (1) ES2158808B1 (fr)
WO (1) WO2001028682A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004067964A1 (fr) 2003-01-28 2004-08-12 Tsinghua University Procede de transfert de fluide et micropompe a action peristaltique
WO2007034404A3 (fr) * 2005-09-20 2007-06-14 Koninkl Philips Electronics Nv Regulateur microfluidique
WO2012127049A1 (fr) * 2011-03-24 2012-09-27 Boehringer Ingelheim Microparts Gmbh Dispositif et procédé de fabrication d'une liaison fluidique entre cavités
US9157460B2 (en) 2012-06-05 2015-10-13 Toyota Motor Engineering & Manufacturing North America, Inc. Controlling a fluid flow with a magnetic field
KR20200034835A (ko) * 2013-03-11 2020-03-31 큐 헬스 인코퍼레이티드 분석물의 검출 및 정량을 위한 시스템 및 방법
USD909600S1 (en) 2015-07-17 2021-02-02 Cue Health Inc. Sample collection device of an analyte detection system
US11237161B2 (en) 2017-01-25 2022-02-01 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
EP3965931A1 (fr) * 2019-05-07 2022-03-16 Lonza Ltd. Système d'échantillonnage avec ensemble cassette remplaçable et procédés d'utilisation de celui-ci
USD951789S1 (en) 2014-05-12 2022-05-17 Cue Health Inc. Reader device for an analyte detection system

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Publication number Priority date Publication date Assignee Title
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes

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WO1996041864A1 (fr) * 1995-06-13 1996-12-27 The Regents Of The University Of California Chambre de microreaction chauffee par laser a diode dotee d'un moyen de detection d'echantillons
WO1998036832A1 (fr) * 1997-02-19 1998-08-27 Institut Für Mikro- Und Informationstechnik Hahn-Schickard-Gesellschaft Dispositif de microdosage et procede permettant de le faire fonctionner
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Publication number Priority date Publication date Assignee Title
US4895500A (en) * 1988-04-08 1990-01-23 Hoek Bertil Micromechanical non-reverse valve
EP0545284A1 (fr) * 1991-11-29 1993-06-09 Canon Kabushiki Kaisha Dispositif de mesure et système de mesure pour échantillons
WO1996041864A1 (fr) * 1995-06-13 1996-12-27 The Regents Of The University Of California Chambre de microreaction chauffee par laser a diode dotee d'un moyen de detection d'echantillons
WO1998036832A1 (fr) * 1997-02-19 1998-08-27 Institut Für Mikro- Und Informationstechnik Hahn-Schickard-Gesellschaft Dispositif de microdosage et procede permettant de le faire fonctionner
US5910856A (en) * 1998-04-16 1999-06-08 Eastman Kodak Company Integrated hybrid silicon-based micro-reflector

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004067964A1 (fr) 2003-01-28 2004-08-12 Tsinghua University Procede de transfert de fluide et micropompe a action peristaltique
CN100344874C (zh) * 2003-01-28 2007-10-24 清华大学 一种流体的传输方法及实现该方法的微型蠕动泵
US8353685B2 (en) 2003-01-28 2013-01-15 Capitalbio Corporation Method for fluid transfer and the micro peristaltic pump
WO2007034404A3 (fr) * 2005-09-20 2007-06-14 Koninkl Philips Electronics Nv Regulateur microfluidique
WO2012127049A1 (fr) * 2011-03-24 2012-09-27 Boehringer Ingelheim Microparts Gmbh Dispositif et procédé de fabrication d'une liaison fluidique entre cavités
US8709353B2 (en) 2011-03-24 2014-04-29 Boehringer Ingelheim Microparts Gmbh Device and method for producing a fluidic connection between cavities
JP2014510918A (ja) * 2011-03-24 2014-05-01 ベーリンガー インゲルハイム マイクロパーツ ゲゼルシャフト ミット ベシュレンクテル ハフツング キャビティ相互間にフルイディック結合部を作る器具及び方法
US9157460B2 (en) 2012-06-05 2015-10-13 Toyota Motor Engineering & Manufacturing North America, Inc. Controlling a fluid flow with a magnetic field
US11845078B2 (en) 2013-03-11 2023-12-19 Cue Health Inc. Systems and methods for detection and quantification of analytes
US11717822B2 (en) 2013-03-11 2023-08-08 Cue Health Inc. System for portable and easy-to-use detection of analytes with mobile computing device
KR102226517B1 (ko) * 2013-03-11 2021-03-11 큐 헬스 인코퍼레이티드 분석물의 검출 및 정량을 위한 시스템 및 방법
KR20200034835A (ko) * 2013-03-11 2020-03-31 큐 헬스 인코퍼레이티드 분석물의 검출 및 정량을 위한 시스템 및 방법
USD951789S1 (en) 2014-05-12 2022-05-17 Cue Health Inc. Reader device for an analyte detection system
USD994516S1 (en) 2014-05-12 2023-08-08 Cue Health Inc. Reader device for an analyte detection system
USD1038801S1 (en) 2014-05-12 2024-08-13 Cue Health Inc. Reader device for an analyte detection system
USD909600S1 (en) 2015-07-17 2021-02-02 Cue Health Inc. Sample collection device of an analyte detection system
US11154866B2 (en) 2015-07-17 2021-10-26 Cue Health Inc. Systems and methods for facilitating fluid flow during enhanced detection and quantification of analytes
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