[go: up one dir, main page]

WO2001026815A1 - Concentrateur centrifuge sous vide chauffe par micro-ondes - Google Patents

Concentrateur centrifuge sous vide chauffe par micro-ondes Download PDF

Info

Publication number
WO2001026815A1
WO2001026815A1 PCT/US2000/006521 US0006521W WO0126815A1 WO 2001026815 A1 WO2001026815 A1 WO 2001026815A1 US 0006521 W US0006521 W US 0006521W WO 0126815 A1 WO0126815 A1 WO 0126815A1
Authority
WO
WIPO (PCT)
Prior art keywords
centrifuge
vacuum
microwave
sample solution
centrifuge apparatus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/006521
Other languages
English (en)
Inventor
William A. Moats
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to AU37419/00A priority Critical patent/AU3741900A/en
Publication of WO2001026815A1 publication Critical patent/WO2001026815A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B15/00—Other accessories for centrifuges
    • B04B15/08—Other accessories for centrifuges for ventilating or producing a vacuum in the centrifuge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/0011—Heating features
    • B01D1/0017—Use of electrical or wave energy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B15/00—Other accessories for centrifuges
    • B04B15/02—Other accessories for centrifuges for cooling, heating, or heat insulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0414—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges
    • B04B7/02—Casings; Lids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B7/00—Elements of centrifuges
    • B04B7/08—Rotary bowls
    • B04B7/085—Rotary bowls fibre- or metal-reinforced

Definitions

  • the present invention relates generally to a centrifugal concentrator. More specifically, the invention is a vacuum operated and microwave heated sample evaporator apparatus devoid of exposed metallic components and utilizing centrifuge tubes.
  • the sample solutions become very cold as they evaporate and, as a result, the rate of evaporation decreases excessively to prolong the evaporation process.
  • Microwave heating provides a simple and effective way to warm sample solutions during the vacuum evaporation process to maintain the evaporation rate.
  • the use of metallic centrifuge components under these aforementioned laboratory apparatus conditions is incompatible with microwave heating. Therefore, the present invention provides a solution to this problem by replacing the metallic centrifuge components entirely with either plastic or carbon- fiber reinforced plastic centrifuge heads and rotors. These components are durable, lightweight, non- corrosive and compatible with microwave heating.
  • Hoyler describes an apparatus for concentrating drugs such as penicillin liquor to a dried product and controlling the effervescence by addition of air.
  • a bell jar contains a circular array of bottles of samples connected by individual pipes to a distributor and to two valved air intake ports. The samples are individually heated by electrodes and evacuated. The apparatus is distinguishable for its individual evacuation and heating of each bottle.
  • U.S. Patent No. 4,637,145 issued on January 20, 1987, to Ko Sugisawa et al . describes a low pressure microwave drying apparatus to prevent arcing by spacing the microwave applying chamber made from metal from the drying chamber made from Teflon, quartz, ceramics, polystyrene, glass fibre, and carbon fibre by utilizing a mathematical formula. The apparatus is distinguishable for its limitation to spacing of the microwave source to the drying chamber.
  • U.S. Patent No. 3,300,129 issued on January 24, 1967, to Enrico Brunati describes a centrifugal separator operating under a vacuum for separating solids, water, and air from spent transformer oil. Dirty oil is introduced into an outer annular chamber for heating by electric heater under an applied vacuum. The oil is then fed into the centrifuge for dispersal and exit of the cleaned oil into an apertured standpipe partially encased by a taller open pipe acting as a liquid seal to prevent foam. The apparatus is distinguishable for its requirement for an electrical heater, various standpipes for suction, and separation of the cleaned oil product .
  • Bodine describes a sonic distillation apparatus for obtaining water and concentrating brine by recycling hot brine from a heat exchanger undergoing sonic wave treatment .
  • the hot brine is fed to a boiler-condensation tank containing another sonic vibration generator to treat influent brine in multiple tubes which aid in condensing the steam into a tray deployed in the tank.
  • the apparatus is distinguishable for its sonic wave treatment of brine .
  • U.S. Patent No. 5,911,885 issued on June 15, 1999, to Thomas L. Owens describes an application of microwave radiation in a specially constructed centrifuge for the separation of emulsions and dispersions.
  • the fluid is introduced within a waveguide element having an expanding-helix waveguide channel receiving microwave power from an external generator.
  • the apparatus is distinguishable in having no need for applying a vacuum.
  • U.S. Patent No. 2,859,534 issued on November 11, 1958, to David A. Copson describes an apparatus for radio- frequency freeze-drying of frozen food.
  • the frozen food samples are placed in containers which are individually attached by pipes to a manifold leading outside the conductive cavity to a vacuum pump and condenser system.
  • An oscillator supplies radio frequency energy through a waveguide into the conductive cavity acted upon by a mode stirrer, i.e., a fan.
  • the apparatus is distinguishable for lacking a centrifuging capacity.
  • a high-speed rotating apparatus having a unique temperature detecting system for treating macromolecular or colloidal solutions to determine molecular weights and distribution thereof.
  • a single transparent cell containing the sample is centrifuged in a chamber under an applied vacuum and a cooling system. Viewing windows in the housing are provided above and below the sample for illuminating and inspecting the revolving sample by an optical apparatus.
  • the centrifuge apparatus is distinguishable for lacking microwave energy application.
  • the invention is a vacuum operated and microwave heated centrifugal concentrator devoid of exposed metallic components.
  • the samples are contained in centrifuge tubes.
  • the centrifugal concentrator includes a cylindrical plastic microwave oven housing, a plastic centrifuge apparatus, a rotatable spindle, an electric motor means, a microwave unit means, and a vacuum means.
  • the oven housing has a top opening, a plastic cover, and a bottom compartment.
  • the sole Figure is a perspective view of a non- metallic centrifugal concentrator for evaporating solutions in centrifuge tubes, operating under a vacuum and being heated by microwave energy according to the present invention.
  • the present invention is directed to a centrifugal concentrator including a centrifuge apparatus 10 housed in a cylindrical plastic microwave oven housing 12.
  • the microwave oven housing has adjustable microwaving power for evaporating sample solutions 14 in multiple centrifuge tubes 16 which are evenly distributed for proper balance.
  • the microwave oven housing 12 has a top opening 18 sealed by a plastic cover 20.
  • the plastic cover 20 is preferably hinged and has a handle 22 and a suitable sealing gasket (not shown) to maintain a vacuum.
  • the dimensions of the oven housing may be adjusted to accommodate various sample volumes .
  • the oven housing 12 and cover 20 are shielded as with a conventional microwave oven to prevent leakage of microwave radiation.
  • the plastic centrifuge apparatus 10 is located within the oven housing 12.
  • the centrifuge apparatus is devoid of exposed metallic parts, so that arcing is not a problem and the samples can be heated by microwave energy.
  • the centrifuge apparatus 10 includes a circular rotor 28.
  • the rotor contains a plurality of evenly distributed receptacles 34.
  • the receptacles 34 are arranged radially around the central cavity for accepting centrifuge tubes 16.
  • the central cavity may be covered by a plastic shield 32.
  • the plastic shield 32 is not sealed; this permits evacuation of the central cavity to evaporate the samples 14.
  • the arrangement is conventional for a centrifuge except in that the centrifuge apparatus is free of metallic parts.
  • the receptacles 34 contain the sample solutions 14 to be evaporated.
  • the rotor 28 may be reinforced with carbon fibers .
  • the centrifuge apparatus 10 may be provided with interchangeable plastic centrifuge heads to accommodate various sizes of sample containers.
  • the centrifuge heads may be reinforced with carbon fibers.
  • a base portion 23 supports the spindle 26 over the bottom compartment 24.
  • the spindle 26 is rotatable and supports the rotor 28 of the centrifuge apparatus 10.
  • the spindle 26 is composed of plastic and may be reinforced with carbon fibers.
  • An electric motor means is provided for rotating the spindle 26 and the centrifuge apparatus 10.
  • the electric motor means is a conventional electric motor as in known centrifuges.
  • the electric motor preferably is located in the bottom compartment 24.
  • a microwave unit means is provided for producing microwave energy to heat the sample solutions 14.
  • the microwave unit means is conventional and may be located in the bottom compartment 24 or at any other appropriate location in the oven housing.
  • a vacuum means is provided for exposing the sample solutions 14 to vacuum to speed evaporation.
  • the vacuum means may include a vacuum regulator control valve 36, an effluent gas outlet conduit 38, a vacuum meter (not shown) , and a vacuum pump (not shown) connected to the microwave oven housing 12.
  • the present invention also includes a method for evaporative concentration.
  • the method includes a step of selecting a centrifugal concentrator as described above.
  • a vacuum source is connected to the oven housing of the centrifugal concentrator.
  • a sample solution is placed in at least one centrifuge tube.
  • the centrifuge tube containing the sample solution is placed in one of the receptacles. If only one solution is used, a centrifuge tube containing a blank solution is preferably placed in the opposite receptacle, for balance.
  • the centrifuge apparatus is then rotated in the conventional manner to centrifuge the sample solution.
  • the sample solution is exposed to vacuum from the vacuum source to speed evaporation of the solution.
  • the centrifuge rotation suppresses foaming due to the vacuum, which avoids loss of sample material.
  • the sample solution is heated with microwave energy to counteract the cooling effect produced by the evaporation. This maintains the desired speed of evaporation without heating the sample solution excessively. Degradation of the sample is avoided and evaporation times are minimized.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Centrifugal Separators (AREA)

Abstract

L'invention concerne un concentrateur centrifuge sous vide chauffé par micro-ondes, destiné à traiter des tubes centrifuges (16) contenant des solutions d'échantillon (14). Le concentrateur fonctionne dans des conditions de vide, et les solutions d'échantillon sont chauffées au moyen d'énergie micro-onde. Ledit concentrateur comprend un logement de four (12) à micro-ondes cylindrique en plastique, un appareil centrifuge (10) en plastique dépourvu de parties métalliques exposées, une unité micro-ondes, et une connexion à la source de vide.
PCT/US2000/006521 1999-10-08 2000-03-14 Concentrateur centrifuge sous vide chauffe par micro-ondes Ceased WO2001026815A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37419/00A AU3741900A (en) 1999-10-08 2000-03-14 Microwave heated centrifugal vacuum concentrator

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15823099P 1999-10-08 1999-10-08
US60/158,230 1999-10-08

Publications (1)

Publication Number Publication Date
WO2001026815A1 true WO2001026815A1 (fr) 2001-04-19

Family

ID=22567197

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/006521 Ceased WO2001026815A1 (fr) 1999-10-08 2000-03-14 Concentrateur centrifuge sous vide chauffe par micro-ondes

Country Status (2)

Country Link
AU (1) AU3741900A (fr)
WO (1) WO2001026815A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7775961B2 (en) * 2006-02-06 2010-08-17 Battelle Energy Alliance, Llc Microwave assisted centrifuge and related methods
KR101119955B1 (ko) 2009-05-11 2012-03-15 주식회사 메디사랑 피브리노겐을 생성하는데 사용되는 항온원심분리기
US8718113B2 (en) 2007-09-13 2014-05-06 Enwave Corporation Apparatus and method for dehydrating biological materials
JP2016195970A (ja) * 2015-04-03 2016-11-24 東京理化器械株式会社 遠心減圧濃縮装置
US10023857B2 (en) 2008-09-12 2018-07-17 En Wave Corporation Apparatus and method for dehydrating biological materials with freezing and microwaving
CN114130045A (zh) * 2021-12-13 2022-03-04 季华实验室 一种超净高纯电子化学品的蒸发浓缩装置及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4030897A (en) * 1974-11-28 1977-06-21 Saint-Gobain Industries Degassing of liquids
US4680439A (en) * 1986-05-30 1987-07-14 Litton Systems, Inc. Plastic microwave oven cavity
US4927406A (en) * 1988-12-15 1990-05-22 Beckman Instruments, Inc. Spring biased drive socket insert for centrifuge rotors
US5211808A (en) * 1990-11-13 1993-05-18 Savant Instruments Microwave heating in a vacuum centrifugal concentrator
US5924972A (en) * 1998-03-24 1999-07-20 Turvaville; L. Jackson Portable D.C. powered centrifuge

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4030897A (en) * 1974-11-28 1977-06-21 Saint-Gobain Industries Degassing of liquids
US4680439A (en) * 1986-05-30 1987-07-14 Litton Systems, Inc. Plastic microwave oven cavity
US4927406A (en) * 1988-12-15 1990-05-22 Beckman Instruments, Inc. Spring biased drive socket insert for centrifuge rotors
US5211808A (en) * 1990-11-13 1993-05-18 Savant Instruments Microwave heating in a vacuum centrifugal concentrator
US5924972A (en) * 1998-03-24 1999-07-20 Turvaville; L. Jackson Portable D.C. powered centrifuge

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7775961B2 (en) * 2006-02-06 2010-08-17 Battelle Energy Alliance, Llc Microwave assisted centrifuge and related methods
US8718113B2 (en) 2007-09-13 2014-05-06 Enwave Corporation Apparatus and method for dehydrating biological materials
US10023857B2 (en) 2008-09-12 2018-07-17 En Wave Corporation Apparatus and method for dehydrating biological materials with freezing and microwaving
US10844366B2 (en) 2008-09-12 2020-11-24 Enwave Corporation Apparatus and method for dehydrating biological materials with freezing and microwaving
KR101119955B1 (ko) 2009-05-11 2012-03-15 주식회사 메디사랑 피브리노겐을 생성하는데 사용되는 항온원심분리기
JP2016195970A (ja) * 2015-04-03 2016-11-24 東京理化器械株式会社 遠心減圧濃縮装置
CN114130045A (zh) * 2021-12-13 2022-03-04 季华实验室 一种超净高纯电子化学品的蒸发浓缩装置及其应用

Also Published As

Publication number Publication date
AU3741900A (en) 2001-04-23

Similar Documents

Publication Publication Date Title
EP1297874B1 (fr) Procédé de détermination de la température d' évaporation des échantions liquides
US5269930A (en) Apparatus and method for supercritical fluid extraction
SU931119A3 (ru) Устройство дл термической обработки материалов
EP2024048B1 (fr) Évaporateur et procédé d'exploitation associé
KR101795796B1 (ko) 다목적 농축 및 추출 장치
US11813555B2 (en) Distillation apparatus and method for extraction of volatile components from biological material, especially from plants
CN105251224B (zh) 一种连续夹带式薄料层微波蒸发方法及装置
WO2001026815A1 (fr) Concentrateur centrifuge sous vide chauffe par micro-ondes
KR20100097499A (ko) 증기를 이용한 추출 및 농축 장치
CN105251225B (zh) 一种多层碟片式离心与重力成膜微波蒸发装置
US6991704B2 (en) Heating of microtitre well plates in centrifugal evaporators
US3270434A (en) Freeze-drying apparatus
US20230079635A1 (en) Extraction freeze drying system with removable condenser
CN110907261A (zh) 行星旋转真空浓缩系统及其工作方法
JP2002514132A (ja) 圧力調整マニホールドを有する固相有機合成デバイス
EP4238625B1 (fr) Dispositif de refroidissement
WO2000013761A1 (fr) Evaporateur a vortex
KR20230089626A (ko) 증류 장치
KR20230099732A (ko) 감압 증류 장치
CN222384194U (zh) 一种化学试剂的分离设备
CN221358540U (zh) 一种化学试剂分离装置
CN105251223A (zh) 一种连续牵引式网膜微波蒸发方法及装置
SU1741841A1 (ru) Способ концентрировани суспензий и растворов и устройство дл его осуществлени
US20240288347A1 (en) Device for managing samples in sample containers under vacuum
SU1579514A1 (ru) Центробежный дистилл тор

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase