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WO2001024699A8 - Non-invasive screening of skin diseases by visible/near-infrared spectroscopy - Google Patents

Non-invasive screening of skin diseases by visible/near-infrared spectroscopy

Info

Publication number
WO2001024699A8
WO2001024699A8 PCT/CA2000/001187 CA0001187W WO0124699A8 WO 2001024699 A8 WO2001024699 A8 WO 2001024699A8 CA 0001187 W CA0001187 W CA 0001187W WO 0124699 A8 WO0124699 A8 WO 0124699A8
Authority
WO
WIPO (PCT)
Prior art keywords
visible
skin
lesions
skin diseases
analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2000/001187
Other languages
French (fr)
Other versions
WO2001024699A2 (en
Inventor
Laura M Mcintosh
Michael Jackson
Henry H Mantsch
James R Mansfield
A Neil Crowson
John W P Toole
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Original Assignee
National Research Council of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Council of Canada filed Critical National Research Council of Canada
Priority to CA2396883A priority Critical patent/CA2396883C/en
Priority to EP00967472A priority patent/EP1237479A2/en
Priority to US10/089,314 priority patent/US7280866B1/en
Priority to AU77662/00A priority patent/AU782431B2/en
Publication of WO2001024699A2 publication Critical patent/WO2001024699A2/en
Publication of WO2001024699A8 publication Critical patent/WO2001024699A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/444—Evaluating skin marks, e.g. mole, nevi, tumour, scar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/445—Evaluating skin irritation or skin trauma, e.g. rash, eczema, wound, bed sore
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7264—Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un outil non invasif pour effectuer le diagnostic de maladies de la peau, destiné à être utilisé en tant que dispositif clinique auxiliaire. L'étude sur laquelle est fondée cette invention avait pour but de déterminer si la spectroscopie dans le visible/infrarouge proche peut être exploité pour la caractérisation non invasive de maladies de la peau. Des spectres in vivo dans le visible et infrarouge proche (400-2500 nm) de tumeurs de la peau (kératoses séniles, carcinomes basocellulaires, naevus mélanocytaires banals communs acquis, naevus mélanocytaires dysplasiques, lentigines actiniques et kératoses séborrhéiques) ont été obtenus au moyen d'une sonde à fibre optique placée sur la peau. On a fait appel à des tests t jumelés, à une analyse de variance et à une analyse discriminatoire de mesures répétées pour déterminer s'il y avait des différences spectrales significatives et si les spectres pouvaient être classés selon le type de lésion. Les tests t jumelés ont montré des différences significatives (p<0,05) entre une peau normale et une peau présentant des lésions, dans plusieurs zones du spectre visible/infrarouge proche. En outre, des différences significatives ont été trouvées entre les groupes de lésions, par analyse de variance. L'analyse discriminatoire linéaire a permis de différencier des spectres résultant de lésions bénignes, en comparaison avec des lésions pré-malignes ou malignes. La spectroscopie dans le visible/infrarouge rouge constitue une technique non invasive prometteuse pour le diagnostic de maladies de la peau.The invention relates to a non-invasive tool for diagnosing skin diseases, for use as an adjunct clinical device. The purpose of the study on which this invention is based was to determine whether visible / near infrared spectroscopy can be used for the non-invasive characterization of skin diseases. In vivo spectra in the visible and near infrared (400-2500 nm) of skin tumors (senile keratoses, basal cell carcinomas, common common melanocytic nevus, dysplastic melanocytic nevus, actinic lentigines and seborrheic keratoses) were obtained by means of '' a fiber optic probe placed on the skin. Combined t-tests, analysis of variance, and discriminatory analysis of repeated measurements were used to determine whether there were significant spectral differences and whether the spectra could be classified by type of lesion. The combined t-tests showed significant differences (p <0.05) between normal skin and skin with lesions, in several areas of the visible / near infrared spectrum. In addition, significant differences were found between the groups of lesions, by analysis of variance. The linear discriminatory analysis made it possible to differentiate spectra resulting from benign lesions, in comparison with pre-malignant or malignant lesions. Red visible / infrared spectroscopy is a promising non-invasive technique for the diagnosis of skin diseases.

PCT/CA2000/001187 1999-10-06 2000-10-05 Non-invasive screening of skin diseases by visible/near-infrared spectroscopy Ceased WO2001024699A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2396883A CA2396883C (en) 1999-10-06 2000-10-05 Non-invasive screening of skin diseases by visible/near-infrared spectroscopy
EP00967472A EP1237479A2 (en) 1999-10-06 2000-10-05 Non-invasive screening of skin diseases by visible/near-infrared spectroscopy
US10/089,314 US7280866B1 (en) 1999-10-06 2000-10-05 Non-invasive screening of skin diseases by visible/near-infrared spectroscopy
AU77662/00A AU782431B2 (en) 1999-10-06 2000-10-05 Non-invasive screening of skin diseases by visible/near-infrared spectroscopy

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15785799P 1999-10-06 1999-10-06
US60/157,857 1999-10-06

Publications (2)

Publication Number Publication Date
WO2001024699A2 WO2001024699A2 (en) 2001-04-12
WO2001024699A8 true WO2001024699A8 (en) 2001-10-04

Family

ID=22565569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/001187 Ceased WO2001024699A2 (en) 1999-10-06 2000-10-05 Non-invasive screening of skin diseases by visible/near-infrared spectroscopy

Country Status (4)

Country Link
EP (1) EP1237479A2 (en)
AU (1) AU782431B2 (en)
CA (1) CA2396883C (en)
WO (1) WO2001024699A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10346757A1 (en) * 2003-10-06 2005-05-12 Pe Diagnostik Gmbh Method for the classification of measured values in medical and biochemical analysis
US20110257492A1 (en) * 2009-01-29 2011-10-20 Tanja Maria Greve Method for determining the state of a skin disorder using near infrared (nir) spectroscopy
EP2490586B1 (en) 2009-10-23 2014-11-12 Medespel Ltd System for noninvasive tissue examination
UA122145C2 (en) 2015-07-10 2020-09-25 Інфектофарм Арцнейміттель Унд Консіліум Гмбх APPLICATION OF POTASSIUM HYDROXIDE IN THE TREATMENT OF ACTINIC KERATOSIS
KR20210095145A (en) 2018-10-23 2021-07-30 에스테틱스 바이오메디컬, 인크. Methods, devices and systems for inducing collagen regeneration
CN119694573A (en) * 2024-12-18 2025-03-25 石家庄市第二医院 An intelligent non-invasive blood sugar detection method suitable for diabetic patients

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5016173A (en) * 1989-04-13 1991-05-14 Vanguard Imaging Ltd. Apparatus and method for monitoring visually accessible surfaces of the body
US6008889A (en) * 1997-04-16 1999-12-28 Zeng; Haishan Spectrometer system for diagnosis of skin disease

Also Published As

Publication number Publication date
AU782431B2 (en) 2005-07-28
CA2396883A1 (en) 2001-04-12
EP1237479A2 (en) 2002-09-11
WO2001024699A2 (en) 2001-04-12
AU7766200A (en) 2001-05-10
CA2396883C (en) 2011-04-12

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