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WO2001018549A8 - Method for identifying modulators of daf-16 - Google Patents

Method for identifying modulators of daf-16

Info

Publication number
WO2001018549A8
WO2001018549A8 PCT/US2000/024487 US0024487W WO0118549A8 WO 2001018549 A8 WO2001018549 A8 WO 2001018549A8 US 0024487 W US0024487 W US 0024487W WO 0118549 A8 WO0118549 A8 WO 0118549A8
Authority
WO
WIPO (PCT)
Prior art keywords
daf
agents
methods
cytoprotective effects
identifying modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/024487
Other languages
French (fr)
Other versions
WO2001018549A1 (en
Inventor
Samuel T Henderson
Thomas E Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TorreyPines Therapeutics Inc
Original Assignee
TorreyPines Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TorreyPines Therapeutics Inc filed Critical TorreyPines Therapeutics Inc
Priority to AU73537/00A priority Critical patent/AU7353700A/en
Publication of WO2001018549A1 publication Critical patent/WO2001018549A1/en
Publication of WO2001018549A8 publication Critical patent/WO2001018549A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention comprises methods for identifying agents that can activate C. elegans DAF-16 and human homologs thereof, or their corresponding genes, whereby cytoprotective effects in cells may be induced. Such cytoprotective effects can result in enhanced environmental stress resistance, increased life span and improved late life vigor without significant inhibition of insulin-signaling pathways. The invention also comprises the therapeutic agents identified and methods of treatment using the agents.
PCT/US2000/024487 1999-09-07 2000-09-07 Method for identifying modulators of daf-16 Ceased WO2001018549A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU73537/00A AU7353700A (en) 1999-09-07 2000-09-07 Therapies and reagents for increasing stress resistance and life span

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15282599P 1999-09-07 1999-09-07
US60/152,825 1999-09-07

Publications (2)

Publication Number Publication Date
WO2001018549A1 WO2001018549A1 (en) 2001-03-15
WO2001018549A8 true WO2001018549A8 (en) 2001-06-07

Family

ID=22544612

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/024487 Ceased WO2001018549A1 (en) 1999-09-07 2000-09-07 Method for identifying modulators of daf-16

Country Status (2)

Country Link
AU (1) AU7353700A (en)
WO (1) WO2001018549A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1581624A4 (en) * 2002-08-09 2007-01-24 Univ California EUKARYOTIC GENES INVOLVED IN THE REGULATION OF ADULT LIVING
US20040121407A1 (en) * 2002-09-06 2004-06-24 Elixir Pharmaceuticals, Inc. Regulation of the growth hormone/IGF-1 axis
US7932049B2 (en) * 2002-12-23 2011-04-26 University Of Massachusetts Methods of identifying longevity modulators and therapeutic methods of use thereof
US7858327B2 (en) * 2002-12-23 2010-12-28 University Of Massachusetts Methods of identifying longevity modulators and therapeutic methods of use thereof
DE10303850A1 (en) * 2003-01-30 2004-08-12 Aventis Pharma Deutschland Gmbh Screening assay based on the forkhead transcription factor dependent sod-3 promoter to identify AKT modulating compounds or upstream regulators such as insulin / IGF1 receptors
US7435868B2 (en) 2003-01-30 2008-10-14 Sanofi-Aventis Deutschland Gmbh Screening assay based on the forkhead transcription factor-dependent sod-3 promoter
JP2007503348A (en) 2003-08-26 2007-02-22 オートリブ ディヴェロプメント アクチボラゲット Belt roller with two tightening devices
US20090280062A1 (en) * 2008-04-17 2009-11-12 Chi-Huey Wong Longevity-promoting effects of acetic acid and reishi polysaccharide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1019092A4 (en) * 1997-05-15 2004-12-15 Gen Hospital Corp THERAPEUTIC AND DIAGNOSTIC TOOLS FOR POOR CARBOHYDRATE TOLERANCE

Also Published As

Publication number Publication date
WO2001018549A1 (en) 2001-03-15
AU7353700A (en) 2001-04-10

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