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WO2001011962A1 - Traitement topique contre la peste d'insecte a administrer aux animaux de compagnie - Google Patents

Traitement topique contre la peste d'insecte a administrer aux animaux de compagnie Download PDF

Info

Publication number
WO2001011962A1
WO2001011962A1 PCT/US2000/019556 US0019556W WO0111962A1 WO 2001011962 A1 WO2001011962 A1 WO 2001011962A1 US 0019556 W US0019556 W US 0019556W WO 0111962 A1 WO0111962 A1 WO 0111962A1
Authority
WO
WIPO (PCT)
Prior art keywords
spinosyn
formulation
animal
physiologically acceptable
controlling
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/019556
Other languages
English (en)
Inventor
Daniel Earl Snyder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Priority to AU66064/00A priority Critical patent/AU6606400A/en
Publication of WO2001011962A1 publication Critical patent/WO2001011962A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members

Definitions

  • Companion animals including but not limited to dogs, cats, and
  • pests include, for example, fleas, lice, mosquitoes,
  • companion animals such as ticks and mosquitoes, are also known to transmit disease.
  • ticks are known to transmit bacterial and viral diseases; and mosquitoes
  • the chemicals used include a variety of carbamates, organophosphates,
  • animals such as cat and dog fleas.
  • the spinosyns are agricultural and renewable.
  • insecticides that have shown activity against southern armyworm and other insects in
  • spinosyn A can provide prolonged residual control of an ectoparasite infestation on companion animals when a single dose of a spinosyn is applied topically to the
  • the invention provides a method for prolonged control of the
  • One aspect of this invention is a long-acting, single-dose topical
  • formulation comprising an ectoparasiticidal amount of a spinosyn, or a
  • the invention relates to the use of a single, long-
  • This invention also relates to a method of controlling an ectoparasite
  • this invention is a method for controlling a cat or dog flea infestation on a companion
  • the invention further relates to an article of manufacture, comprising
  • packaging material and a formulation for controlling an ectoparasite infestation on a
  • formulation comprises a long-acting topical unit dose of a formulation of this invention, i.e.,
  • companion animal is a dog or a cat.
  • the label or package insert will indicate the
  • each kit would typically be sufficient to control the ectoparasite infestation for a
  • the invention also relates to the use of a spinosyn, or a physiologically
  • topical medicament for controlling an ectoparasite infestation on a companion animal.
  • spinosyn A and spinosyn D also called A83543A
  • Spinosyn A and spinosyn D are the two spinosyns that are most active
  • spinosyn The major spinosyn factor, spinosyn
  • A is known to have an excellent human and animal safety and toxicological profile.
  • Each spinosyn has a 12-membered macrocyclic ring that is part of an
  • spinosyns A to J A83543A to J.
  • the primary components are spinosyns
  • spinosyn or a derivative thereof as used herein refers to an
  • spinosyn component will also be
  • the spinosyns can react to form salts that are also useful in the
  • spinosyn A can be neutralized with an
  • compositions particularly useful include salts formed by
  • formulations of this invention may further include, in combination
  • carbamates foramidines, avermectins, milbemycins, insect growth regulators
  • spinosyns are naturally derived fermentation products, and spinosyn A has excellent human and animal safety profile, in contrast to the profiles
  • spinosyns can be used on companion
  • Spinosyns can be used, therefore, in integrated pest management
  • topical formulation means a formulation that is suitable to
  • Topical application to the external surface of the animal can be diffuse, as
  • Topical formulations can be applied on any part of the animal's body, but are not
  • spinosyn component or components typically applied on the head, neck or dorsal midline of the body.
  • the spinosyn component or components either alone or in
  • controlling an ectoparasite infestation refers to preventing
  • ectoparasites include the egg, larval, pupal, nymphal and
  • Prolonged time comprises a period of at least 7 days
  • spinosyn component useful methods of topically applying the spinosyn component are spot-ons, sprays and
  • Spot-on treatments are ones in which the active agent is applied once as a
  • the area at the base of the neck between the shoulder blades is suitable for
  • amount refer to the amount needed to control the particular ectoparasite infestation.
  • an effective amount is from 1 to 100 mg of the spinosyn per
  • the effective amount is
  • spinosyn component will typically comprise from 10 to 60 percent by weight of the
  • Dogs of the beagle breed were separated into 5 groups, with two dogs
  • the spray solutions were prepared by making a
  • IPM isopropyl myristate
  • Example 1 The treatments were applied either as a spot-on or a spray.
  • control groups (one housed inside and one housed outside) were treated spot-on with
  • the treatment groups were treated with different doses of spinosad and
  • Table 1 Percent Reduction in Adult Flea Counts in Dogs Treated with Spinosad
  • Example 1 and separated into groups (3 dogs per group). Spinosad was applied as a
  • Example 2 In two groups, it was administered in an aqueous
  • control group was treated with a spot-on with IPM vehicle
  • Treatment Group T3 and the control group were observed for an additional 42 days.
  • the results observed at days 49, 56, 63, 70, 77 and 84 are summarized in Table 3a.
  • control group was untreated, and 4 groups were treated with an aqueous suspension of
  • the bottom of the petri dishes had a mesh that allowed the stable flies to probe

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des formulations unidose à administrer par voie topique permettant de lutter contre l'infestation par ectoparasite d'un animal de compagnie pendant une période prolongée. Ces formulations renferment un composant de spinosyne ou son dérivé physiologiquement acceptable ou son sel et un support physiologiquement acceptable. L'invention concerne aussi des procédés destinés à lutter contre les infestations pendant une période prolongée consistant à administrer par voie topique ces formulations à l'animal malade.
PCT/US2000/019556 1999-08-12 2000-08-02 Traitement topique contre la peste d'insecte a administrer aux animaux de compagnie Ceased WO2001011962A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU66064/00A AU6606400A (en) 1999-08-12 2000-08-02 Topical treatment for insect pests in companion animals

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14854899P 1999-08-12 1999-08-12
US60/148,548 1999-08-12

Publications (1)

Publication Number Publication Date
WO2001011962A1 true WO2001011962A1 (fr) 2001-02-22

Family

ID=22526234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/019556 Ceased WO2001011962A1 (fr) 1999-08-12 2000-08-02 Traitement topique contre la peste d'insecte a administrer aux animaux de compagnie

Country Status (3)

Country Link
AU (1) AU6606400A (fr)
CO (1) CO5221063A1 (fr)
WO (1) WO2001011962A1 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6927210B1 (en) 1999-08-12 2005-08-09 Eli Lilly And Company Ectoparasiticidal aqueous suspension formulations of spinosyns
US6933318B1 (en) 1999-08-12 2005-08-23 Eli Lilly And Company Topical organic ectoparasiticidal formulations
US6955818B1 (en) 1999-12-02 2005-10-18 Eli Lilly And Company Pour-on formulations
US7034130B2 (en) 2001-07-20 2006-04-25 Bayer Cropscience Ag Method for producing novel spinosyn derivatives
US7772194B2 (en) 2001-09-17 2010-08-10 Eli Lilly And Company Pesticidal formulations
EP2248422A1 (fr) * 2009-05-08 2010-11-10 Novartis AG Compositions pour lutter contre les ectoparasites
WO2010148053A1 (fr) * 2009-06-19 2010-12-23 Eli Lilly And Company Procédés et formulations ectoparasiticides
US8921327B2 (en) 2012-11-14 2014-12-30 Eli Lilly And Company Ectoparasiticidal methods and formulations
US20230404077A1 (en) * 2022-06-15 2023-12-21 EctoGuard, LLC Methods and formulations for controlling flea infestations
EP4304571A4 (fr) * 2021-03-11 2025-01-22 In the Bowl Animal Health, Inc. Aliments pour chiens administrés par voie orale et procédés de lutte contre les infestations de puces chez le chien
EP4358736A4 (fr) * 2021-06-25 2025-04-09 In the Bowl Animal Health, Inc. Aliment pour félins destiné à être administré par voie orale et procédés de lutte contre les infestations par les puces chez un félin

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0375316A1 (fr) * 1988-12-19 1990-06-27 DowElanco Composés macrolides
US5202242A (en) * 1991-11-08 1993-04-13 Dowelanco A83543 compounds and processes for production thereof
WO1993009126A1 (fr) * 1991-11-08 1993-05-13 Dowelanco Nouveaux composes a83543 et leur procede de production
WO1994020518A1 (fr) * 1993-03-12 1994-09-15 Dowelanco Nouveaux composes a83543 et procede de production desdits composes
WO1997000265A1 (fr) * 1995-06-14 1997-01-03 Dowelanco Modification synthetique de composes de spinosyne
US5591606A (en) * 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
US6001981A (en) * 1996-06-13 1999-12-14 Dow Agrosciences Llc Synthetic modification of Spinosyn compounds
EP0968706A2 (fr) * 1998-07-02 2000-01-05 Eli Lilly And Company Compositions contenant de l'spynosine pour controller les poux humains

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0375316A1 (fr) * 1988-12-19 1990-06-27 DowElanco Composés macrolides
US5202242A (en) * 1991-11-08 1993-04-13 Dowelanco A83543 compounds and processes for production thereof
WO1993009126A1 (fr) * 1991-11-08 1993-05-13 Dowelanco Nouveaux composes a83543 et leur procede de production
US5591606A (en) * 1992-11-06 1997-01-07 Dowelanco Process for the production of A83543 compounds with Saccharopolyspora spinosa
US5631155A (en) * 1992-11-06 1997-05-20 Dowelanco Saccharopolyspora spinosa strain
US5767253A (en) * 1992-11-06 1998-06-16 Dow Agrosciences Llc A83543 Compounds; factors Q, R, S, and T
WO1994020518A1 (fr) * 1993-03-12 1994-09-15 Dowelanco Nouveaux composes a83543 et procede de production desdits composes
WO1997000265A1 (fr) * 1995-06-14 1997-01-03 Dowelanco Modification synthetique de composes de spinosyne
US6001981A (en) * 1996-06-13 1999-12-14 Dow Agrosciences Llc Synthetic modification of Spinosyn compounds
EP0968706A2 (fr) * 1998-07-02 2000-01-05 Eli Lilly And Company Compositions contenant de l'spynosine pour controller les poux humains

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6933318B1 (en) 1999-08-12 2005-08-23 Eli Lilly And Company Topical organic ectoparasiticidal formulations
US6927210B1 (en) 1999-08-12 2005-08-09 Eli Lilly And Company Ectoparasiticidal aqueous suspension formulations of spinosyns
US6955818B1 (en) 1999-12-02 2005-10-18 Eli Lilly And Company Pour-on formulations
US7034130B2 (en) 2001-07-20 2006-04-25 Bayer Cropscience Ag Method for producing novel spinosyn derivatives
US8048861B2 (en) 2001-09-17 2011-11-01 Eli Lilly And Company Pesticidal formulations
US7772194B2 (en) 2001-09-17 2010-08-10 Eli Lilly And Company Pesticidal formulations
EP2248422A1 (fr) * 2009-05-08 2010-11-10 Novartis AG Compositions pour lutter contre les ectoparasites
WO2010148053A1 (fr) * 2009-06-19 2010-12-23 Eli Lilly And Company Procédés et formulations ectoparasiticides
CN102802414A (zh) * 2009-06-19 2012-11-28 伊莱利利公司 杀体外寄生虫方法和制剂
JP2012530709A (ja) * 2009-06-19 2012-12-06 イーライ リリー アンド カンパニー 外部寄生生物撲滅方法および製剤
US8871727B2 (en) 2009-06-19 2014-10-28 Eli Lilly And Company Ectoparasiticidal methods and formulations
US8921327B2 (en) 2012-11-14 2014-12-30 Eli Lilly And Company Ectoparasiticidal methods and formulations
EP4304571A4 (fr) * 2021-03-11 2025-01-22 In the Bowl Animal Health, Inc. Aliments pour chiens administrés par voie orale et procédés de lutte contre les infestations de puces chez le chien
EP4358736A4 (fr) * 2021-06-25 2025-04-09 In the Bowl Animal Health, Inc. Aliment pour félins destiné à être administré par voie orale et procédés de lutte contre les infestations par les puces chez un félin
US20230404077A1 (en) * 2022-06-15 2023-12-21 EctoGuard, LLC Methods and formulations for controlling flea infestations

Also Published As

Publication number Publication date
AU6606400A (en) 2001-03-13
CO5221063A1 (es) 2002-11-28

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