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WO2001091798A3 - Composes de promedicaments a activation tumorale et procedes de fabrication et d'utilisation de ces derniers - Google Patents

Composes de promedicaments a activation tumorale et procedes de fabrication et d'utilisation de ces derniers Download PDF

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Publication number
WO2001091798A3
WO2001091798A3 PCT/EP2001/006106 EP0106106W WO0191798A3 WO 2001091798 A3 WO2001091798 A3 WO 2001091798A3 EP 0106106 W EP0106106 W EP 0106106W WO 0191798 A3 WO0191798 A3 WO 0191798A3
Authority
WO
WIPO (PCT)
Prior art keywords
prodrug compounds
activated prodrug
methods
biologically active
tumor activated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/006106
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English (en)
Other versions
WO2001091798A2 (fr
Inventor
Andre Trouet
Vincent Dubois
Arnold Oronsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite Catholique de Louvain UCL
Original Assignee
Universite Catholique de Louvain UCL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Catholique de Louvain UCL filed Critical Universite Catholique de Louvain UCL
Priority to EP01957808A priority Critical patent/EP1286700A2/fr
Priority to CA002408103A priority patent/CA2408103A1/fr
Priority to JP2001587810A priority patent/JP2003534387A/ja
Priority to US10/296,954 priority patent/US20040014652A1/en
Priority to AU2001279630A priority patent/AU2001279630A1/en
Publication of WO2001091798A2 publication Critical patent/WO2001091798A2/fr
Anticipated expiration legal-status Critical
Publication of WO2001091798A3 publication Critical patent/WO2001091798A3/fr
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux composés de promédicaments, des compositions renfermant les composés de promédicaments précités, des procédés de fabrication des composés de promédicaments précités et des procédés d'utilisation de ces derniers. Les composés de promédicaments de l'invention comprennent une entité biologiquement active liée à un fragment masquant via un fragment de liaison. Les composés de promédicaments de l'invention sont sélectivement activés sur les cellules cibles ou à proximité de celles-ci et ils présentent une toxicité inférieure et, éventuellement, une demi-vie sérique ou in vivo plus longue que l'entité biologiquement active correspondante pure.
PCT/EP2001/006106 2000-06-01 2001-05-29 Composes de promedicaments a activation tumorale et procedes de fabrication et d'utilisation de ces derniers Ceased WO2001091798A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01957808A EP1286700A2 (fr) 2000-06-01 2001-05-29 Composes de promedicaments a activation tumorale et procedes de fabrication et d'utilisation de ces derniers
CA002408103A CA2408103A1 (fr) 2000-06-01 2001-05-29 Composes de promedicaments a activation tumorale et procedes de fabrication et d'utilisation de ces derniers
JP2001587810A JP2003534387A (ja) 2000-06-01 2001-05-29 腫瘍活性化プロドラッグ化合物、並びにこれらの製造方法及び使用方法
US10/296,954 US20040014652A1 (en) 2000-06-01 2001-05-29 Tumor activated prodrug compounds and methods of making and using the same
AU2001279630A AU2001279630A1 (en) 2000-06-01 2001-05-29 Tumor activated prodrug compounds

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US20899600P 2000-06-01 2000-06-01
US60/208,996 2000-06-01
EP00870130.2 2000-06-15
EP00870130 2000-06-15
EP00870306 2000-12-18
EP00870306.8 2000-12-18
EP01957808A EP1286700A2 (fr) 2000-06-01 2001-05-29 Composes de promedicaments a activation tumorale et procedes de fabrication et d'utilisation de ces derniers

Publications (2)

Publication Number Publication Date
WO2001091798A2 WO2001091798A2 (fr) 2001-12-06
WO2001091798A3 true WO2001091798A3 (fr) 2002-12-05

Family

ID=27440072

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/006106 Ceased WO2001091798A2 (fr) 2000-06-01 2001-05-29 Composes de promedicaments a activation tumorale et procedes de fabrication et d'utilisation de ces derniers

Country Status (2)

Country Link
EP (1) EP1286700A2 (fr)
WO (1) WO2001091798A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9169321B2 (en) 2007-08-22 2015-10-27 The Regents Of The University Of California Activatable binding polypeptides and methods of identification and use thereof

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US20040097586A1 (en) * 2001-01-30 2004-05-20 Andre Trouet Anti-tumor compounds
KR100468316B1 (ko) 2002-01-29 2005-01-27 주식회사 웰진 Ｄｎａ의 세포 또는 조직 내 전달 효율을 높이는 펩타이드
JP4699755B2 (ja) * 2002-08-23 2011-06-15 ガブリエル ムルソフ， 腫瘍細胞におけるアポトーシスのＨｓｐ７０／Ｈｓｐ７０ペプチド依存性誘導物質としてのグランザイムＢの使用
US20050043215A1 (en) * 2003-02-19 2005-02-24 Tamara Minko Complex drug delivery composition and method for treating cancer
FR2858936A1 (fr) * 2003-08-22 2005-02-25 Diatos Potentialisation de l'activation de prodrogues de haut poids moleculaire
WO2005115457A2 (fr) * 2004-05-10 2005-12-08 University Of Utah Research Foundation Ciblage actif et passif combines d'agents biologiquement actifs
EP1674113A1 (fr) * 2004-12-22 2006-06-28 F. Hoffmann-La Roche Ag Conjugués de l'IGF-1 et du poly(éthylène glycol)
US7214767B2 (en) * 2005-05-25 2007-05-08 Hiroshi Kanno VHL peptide
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WO2009021754A2 (fr) 2007-08-15 2009-02-19 Bayer Schering Pharma Aktiengesellschaft Anticorps monospécifiques et multispécifiques, et procédés d'utilisation
AU2013202755B2 (en) * 2007-08-22 2016-05-12 Cytomx Therapeutics, Inc. Activatable binding polypeptides and methods of identification and use thereof
AU2016213702C1 (en) * 2007-08-22 2018-11-29 Cytomx Therapeutics, Inc. Activatable binding polypeptides and methods of identification and use thereof
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RU2713121C2 (ru) 2012-04-27 2020-02-03 Сайтомкс Терапьютикс, Инк. Активируемые антитела, которые связываются с рецептором эпидермального фактора роста, и способы их применения
US9856314B2 (en) 2012-06-22 2018-01-02 Cytomx Therapeutics, Inc. Activatable antibodies having non-binding steric moieties and methods of using the same
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9169321B2 (en) 2007-08-22 2015-10-27 The Regents Of The University Of California Activatable binding polypeptides and methods of identification and use thereof

Also Published As

Publication number Publication date
EP1286700A2 (fr) 2003-03-05
WO2001091798A2 (fr) 2001-12-06

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