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WO2001090329A3 - A novel human acyltransferase family member and uses thereof - Google Patents

A novel human acyltransferase family member and uses thereof Download PDF

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Publication number
WO2001090329A3
WO2001090329A3 PCT/US2001/016771 US0116771W WO0190329A3 WO 2001090329 A3 WO2001090329 A3 WO 2001090329A3 US 0116771 W US0116771 W US 0116771W WO 0190329 A3 WO0190329 A3 WO 0190329A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
expression vectors
provides isolated
acyltransferase family
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/016771
Other languages
French (fr)
Other versions
WO2001090329A2 (en
Inventor
Rachel A Meyers
Mark Williamson
John Joseph Hunter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
Original Assignee
Millennium Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Priority to EP01941580A priority Critical patent/EP1294861A2/en
Priority to AU2001274921A priority patent/AU2001274921A1/en
Publication of WO2001090329A2 publication Critical patent/WO2001090329A2/en
Publication of WO2001090329A3 publication Critical patent/WO2001090329A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides isolated nucleic acids molecules, designated 46745 nucleic acid molecules, which encode novel acyltransferase family members. Elevated expression of 46745 mRNA was detected in lung, breast, and colon tumors as compared to normal cells derived from these tissues. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 46745 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 46745 gene has been introduced or disrupted. The invention still further provides isolated 46745 proteins, fusion proteins, antigenic peptides and anti-46745 antibodies. Therapeutic and diagnostic methods utilizing compositions of the invention to, for example, treat, prevent and/or diagnose neoplastic conditions, are also provided.
PCT/US2001/016771 2000-05-23 2001-05-23 A novel human acyltransferase family member and uses thereof Ceased WO2001090329A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01941580A EP1294861A2 (en) 2000-05-23 2001-05-23 A novel human acyltransferase family member and uses thereof
AU2001274921A AU2001274921A1 (en) 2000-05-23 2001-05-23 46745, a novel human acyltransferase family member and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57645500A 2000-05-23 2000-05-23
US09/576,455 2000-05-23

Publications (2)

Publication Number Publication Date
WO2001090329A2 WO2001090329A2 (en) 2001-11-29
WO2001090329A3 true WO2001090329A3 (en) 2002-06-06

Family

ID=24304493

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/016771 Ceased WO2001090329A2 (en) 2000-05-23 2001-05-23 A novel human acyltransferase family member and uses thereof

Country Status (3)

Country Link
EP (1) EP1294861A2 (en)
AU (1) AU2001274921A1 (en)
WO (1) WO2001090329A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1455815A4 (en) 2001-12-19 2006-11-02 Millennium Pharm Inc Human diacylglycerol acyltransferase 2 (dgat2)family members and uses therefor
US20140227690A1 (en) * 2013-02-08 2014-08-14 St. John Heallth Methods and compositions for assessment of fetal lung maturity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997045439A1 (en) * 1996-05-30 1997-12-04 The Trustees Of Columbia University In The City Of New York Dna encoding acylcoenzyme a: cholesterol acyltransferase and uses thereof
WO1998054302A2 (en) * 1997-05-27 1998-12-03 Icos Corporation Human lysophosphatidic acid acyltransferase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997045439A1 (en) * 1996-05-30 1997-12-04 The Trustees Of Columbia University In The City Of New York Dna encoding acylcoenzyme a: cholesterol acyltransferase and uses thereof
WO1998054302A2 (en) * 1997-05-27 1998-12-03 Icos Corporation Human lysophosphatidic acid acyltransferase

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CASES S ET AL: "IDENTIFICATION OF A GENE ENCODING AN ACYL COA:DIACYLGLYCEROL ACYLTRANSFERASE, A KEY ENZYME IN TRIACYLGLYCEROL SYNTHESIS", CELL BIOLOGY, XX, XX, vol. 95, October 1998 (1998-10-01), pages 13018 - 13023, XP002919933 *
DATABASE SWALL 1 March 2001 (2001-03-01), XP002192369 *
KLEIN H-G ET AL: "FISH EYE SYNDROME: A MOLECULAR DEFECT IN THE LECITHIN-CHOLESTEROL ACYLTRANSFERASE (LCAT) GENE ASSOCIATED WITH NORMAL ALPHA-LCAT- SPECIFIC ACTIVITY IMPLICATIONS FOR CLASSIFICATION AND PROGNOSIS", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 92, no. 1, 1 July 1993 (1993-07-01), pages 479 - 485, XP000576153, ISSN: 0021-9738 *

Also Published As

Publication number Publication date
AU2001274921A1 (en) 2001-12-03
WO2001090329A2 (en) 2001-11-29
EP1294861A2 (en) 2003-03-26

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