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WO2001088538A8 - Compositions and methods for epitope mapping - Google Patents

Compositions and methods for epitope mapping

Info

Publication number
WO2001088538A8
WO2001088538A8 PCT/US2001/015450 US0115450W WO0188538A8 WO 2001088538 A8 WO2001088538 A8 WO 2001088538A8 US 0115450 W US0115450 W US 0115450W WO 0188538 A8 WO0188538 A8 WO 0188538A8
Authority
WO
WIPO (PCT)
Prior art keywords
ligands
diverse population
reagent
diverse
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/015450
Other languages
French (fr)
Other versions
WO2001088538A2 (en
WO2001088538A3 (en
Inventor
David P Dumas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002408835A priority Critical patent/CA2408835A1/en
Priority to EP01935435A priority patent/EP1314032A2/en
Priority to AU2001261533A priority patent/AU2001261533A1/en
Publication of WO2001088538A2 publication Critical patent/WO2001088538A2/en
Publication of WO2001088538A8 publication Critical patent/WO2001088538A8/en
Anticipated expiration legal-status Critical
Publication of WO2001088538A3 publication Critical patent/WO2001088538A3/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
    • C07K16/205—Plasmodium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention provides a composition comprising a diverse population of reagent ligands attached to a solid support and a diverse populatin of reagent antibodies specifically bound to the reagent ligands. The ligands can be peptides, oligosaccharides, oligonucleotides, or organic molecules. The invention additionally provides methods of determining an epitope in a sample contacting a composition comprising a diverse population of ligands attached to a solid support and a diverse population of antibodies specifically bound to each of the ligands with a sample; and detecting the antibodies bound to the diverse population of ligands. The invention further provides methods of diagnosing a disease, identifying a potential therapeutic agent, and mapping accessible epitopes of a polypeptide using invention compositions.
PCT/US2001/015450 2000-05-12 2001-05-10 Compositions and methods for epitope mapping Ceased WO2001088538A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002408835A CA2408835A1 (en) 2000-05-12 2001-05-10 Compositions and methods for epitope mapping
EP01935435A EP1314032A2 (en) 2000-05-12 2001-05-10 Compositions and methods for epitope mapping
AU2001261533A AU2001261533A1 (en) 2000-05-12 2001-05-10 Compositions and methods for epitope mapping

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56971300A 2000-05-12 2000-05-12
US09/569,713 2000-05-12

Publications (3)

Publication Number Publication Date
WO2001088538A2 WO2001088538A2 (en) 2001-11-22
WO2001088538A8 true WO2001088538A8 (en) 2002-03-28
WO2001088538A3 WO2001088538A3 (en) 2003-03-27

Family

ID=24276552

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015450 Ceased WO2001088538A2 (en) 2000-05-12 2001-05-10 Compositions and methods for epitope mapping

Country Status (4)

Country Link
EP (1) EP1314032A2 (en)
AU (1) AU2001261533A1 (en)
CA (1) CA2408835A1 (en)
WO (1) WO2001088538A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10310261A1 (en) * 2003-03-05 2004-09-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Identification of antigen epitopes
MX2011012933A (en) 2009-06-02 2012-03-07 Univ Texas Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases.
WO2011047257A1 (en) 2009-10-16 2011-04-21 The Board Of Regents Of The University Of Texas System Compositions and methods for producing cyclic peptoid libraries
GB201704823D0 (en) 2017-03-27 2017-05-10 Univ Leicester Methods and kits for determining binding sites
CN114853848B (en) * 2022-05-24 2023-10-24 陕西慧康生物科技有限责任公司 Polypeptide compounds and their application in the preparation of drugs for the treatment of liver fibrosis
WO2024059655A1 (en) * 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures

Also Published As

Publication number Publication date
WO2001088538A2 (en) 2001-11-22
EP1314032A2 (en) 2003-05-28
AU2001261533A1 (en) 2001-11-26
WO2001088538A3 (en) 2003-03-27
CA2408835A1 (en) 2001-11-22

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