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WO2001082858A3 - Novel compounds for the treatment of inflammatory and cardiovascular diseases - Google Patents

Novel compounds for the treatment of inflammatory and cardiovascular diseases Download PDF

Info

Publication number
WO2001082858A3
WO2001082858A3 PCT/EP2001/005043 EP0105043W WO0182858A3 WO 2001082858 A3 WO2001082858 A3 WO 2001082858A3 EP 0105043 W EP0105043 W EP 0105043W WO 0182858 A3 WO0182858 A3 WO 0182858A3
Authority
WO
WIPO (PCT)
Prior art keywords
butyl
inflammatory
treatment
isobutyl
tert
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/005043
Other languages
German (de)
French (fr)
Other versions
WO2001082858A2 (en
Inventor
Wolf-Georg Forssmann
Helmut Drexler
Michael Walden
Bernhard Schieffer
Boris Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IPF Pharmaceuticals GmbH
Original Assignee
IPF Pharmaceuticals GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IPF Pharmaceuticals GmbH filed Critical IPF Pharmaceuticals GmbH
Priority to AU2001267404A priority Critical patent/AU2001267404A1/en
Publication of WO2001082858A2 publication Critical patent/WO2001082858A2/en
Publication of WO2001082858A3 publication Critical patent/WO2001082858A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention concerns a compound having structural formula (I), wherein R1 represents H, substituted or unsubstituted alkyl or acyl groups, especially methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert. Butyl; X = halogen or OH; R2 represents H, substituted or unsubstituted alkyl or acyl groups, especially methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert. butyl, halogen or OH; R3 represents H, substituted or unsubstituted alkyl or acyl groups, especially methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert. butyl, halogen or OH; R4 represents H, substituted or unsubstituted alkyl or acyl groups, especially methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert. butyl or is a metal radical, especially an alkali cation.
PCT/EP2001/005043 2000-05-04 2001-05-04 Novel compounds for the treatment of inflammatory and cardiovascular diseases Ceased WO2001082858A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001267404A AU2001267404A1 (en) 2000-05-04 2001-05-04 Novel compounds for the treatment of inflammatory and cardiovascular diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10021615 2000-05-04
DE10021615.3 2000-05-04

Publications (2)

Publication Number Publication Date
WO2001082858A2 WO2001082858A2 (en) 2001-11-08
WO2001082858A3 true WO2001082858A3 (en) 2002-06-27

Family

ID=7640695

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/005043 Ceased WO2001082858A2 (en) 2000-05-04 2001-05-04 Novel compounds for the treatment of inflammatory and cardiovascular diseases

Country Status (2)

Country Link
AU (1) AU2001267404A1 (en)
WO (1) WO2001082858A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7199144B2 (en) 2003-04-21 2007-04-03 Teva Pharmaceuticals Industries, Ltd. Process for the preparation of valsartan and intermediates thereof
US7232828B2 (en) 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
US7378531B2 (en) 2003-04-21 2008-05-27 Teva Pharmaceutical Industries Ltd Process for the preparation of valsartan

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042443A2 (en) * 2000-11-23 2002-05-30 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Use of modulators of eukaryotic signal transduction pathways for the treatment of helicobacter infections
EP1356815A4 (en) * 2001-01-29 2007-03-07 Takeda Pharmaceutical PAIN-RELIEF AND ANTI-INFLAMMATORY ACTIVE SUBSTANCES
TWI299663B (en) * 2002-05-14 2008-08-11 Novartis Ag Methods of treatment
DE602004013405T2 (en) 2003-03-17 2009-05-07 Teva Pharmaceutical Industries Ltd. POLYMORPH SHAPES OF VALSARTAN
EP1950204A1 (en) 2003-03-17 2008-07-30 Teva Pharmaceutical Industries Ltd. Amorphous form of valsartan
EP2321281A4 (en) * 2008-09-02 2011-09-28 Elder Pharmaceuticals Ltd Anti inflammatory compounds
WO2012056294A1 (en) 2010-10-29 2012-05-03 Jubilant Life Sciences Ltd. An improved process for the preparation of n-pentanoyl-n-[[2'-(1h-tetrazol-5-yi)[1,1'-biphenyl]-4-yi]methyl]-l-valine
US12365654B2 (en) 2019-12-02 2025-07-22 Harman Finochem Limited Process for the preparation of highly pure valsartan

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000977A2 (en) * 1990-07-13 1992-01-23 E.I. Du Pont De Nemours And Company 4-alkylimidazole derivatives
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
WO1992020342A1 (en) * 1991-05-15 1992-11-26 E.I. Du Pont De Nemours And Company Novel composition of angiotensin-ii receptor antagonists and calcium channel blockers
EP0581003A1 (en) * 1992-06-26 1994-02-02 Bayer Ag Imidazolyl substituted cyclohexane derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
WO1992000977A2 (en) * 1990-07-13 1992-01-23 E.I. Du Pont De Nemours And Company 4-alkylimidazole derivatives
WO1992020342A1 (en) * 1991-05-15 1992-11-26 E.I. Du Pont De Nemours And Company Novel composition of angiotensin-ii receptor antagonists and calcium channel blockers
EP0581003A1 (en) * 1992-06-26 1994-02-02 Bayer Ag Imidazolyl substituted cyclohexane derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7232828B2 (en) 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
US7199144B2 (en) 2003-04-21 2007-04-03 Teva Pharmaceuticals Industries, Ltd. Process for the preparation of valsartan and intermediates thereof
US7378531B2 (en) 2003-04-21 2008-05-27 Teva Pharmaceutical Industries Ltd Process for the preparation of valsartan

Also Published As

Publication number Publication date
AU2001267404A1 (en) 2001-11-12
WO2001082858A2 (en) 2001-11-08

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