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WO2001079079A1 - Assemblage de soupape pour des distributeurs de doses - Google Patents

Assemblage de soupape pour des distributeurs de doses Download PDF

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Publication number
WO2001079079A1
WO2001079079A1 PCT/GB2001/001692 GB0101692W WO0179079A1 WO 2001079079 A1 WO2001079079 A1 WO 2001079079A1 GB 0101692 W GB0101692 W GB 0101692W WO 0179079 A1 WO0179079 A1 WO 0179079A1
Authority
WO
WIPO (PCT)
Prior art keywords
metering chamber
valve stem
vent
valve assembly
seals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2001/001692
Other languages
English (en)
Inventor
Joseph Groeger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Presspart Manufacturing Ltd
Original Assignee
Presspart Manufacturing Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Presspart Manufacturing Ltd filed Critical Presspart Manufacturing Ltd
Priority to US10/240,770 priority Critical patent/US20040222244A1/en
Priority to AU93375/01A priority patent/AU9337501A/en
Priority to EP01969039A priority patent/EP1272401A1/fr
Publication of WO2001079079A1 publication Critical patent/WO2001079079A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
    • B65D83/52—Metering valves; Metering devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/42—Filling or charging means
    • B65D83/425—Delivery valves permitting filling or charging

Definitions

  • the present invention relates to a metered dose dispenser.
  • Metered dose dispensers find many practical applications.
  • the metered dose dispenser is typically used to dispense a measured dose of a pharmaceutically active substance from a pressurised aerosol canister into an airway through which inhalation takes place.
  • a valve assembly for a typical metered dose inhaler is illustrated in figure 1. It is designed for attachment to a pressurised canister within which is contained a drug product and a propellant.
  • the valve assembly constitutes a metered dose dispenser, or metering valve, the purpose of which is to allow doses of the drug product, of a controlled size, to be dispensed into the inhalation airway via a metering chamber 10.
  • the boundary wall 12 between the metering chamber 10 and the pressurised canister, forming the lower wall of the metering chamber 10, includes a first vent 14 that allows the metering chamber 10 to communicate with the pressurised canister.
  • a second vent 16 is provided in the opposite, upper wall 18 of the metering chamber 10 and both vents 14, 16 are occupied by a valve stem 20 which bears against a circular elastomeric seal in each 22, 24.
  • the valve stem 20 is in the form of a tube that is closed at its lower, innermost end 26 and open at its upper, outermost end 28 and includes a side hole 30 communicating between the inside and the outside of the valve stem 20 and an indented channel 32 towards its lower end 26 that interrupts its normally circular cross-section.
  • the valve stem 20 is normally in an elevated or extended position, in which the channel 32 is located within the first vent 14 and allows the canister to communicate with the metering chamber 10. This primes the metering chamber 10.
  • the valve stem 20 is depressed against the bias of a spring 34, firstly the channel 32 moves below the seal 22 in the first vent 14, isolating the canister from the metering chamber 10. This is the situation as illustrated in figure 1.
  • the side hole 30 moves below the seal 24 in the second vent 16, allowing the metering chamber 10 to communicate with the outside via the side hole 30 and the open end 28 of the valve stem 20.
  • the open end 28 of the valve stem 20 is located in a rebate in an inhaler body that acts as a bearing surface for depression of the valve stem 20 and also provides a conduit for the drug to be dispensed into the inhalation airway.
  • CFC chlorofluorocarbon
  • the drug product may be more inclined to agglomerate, particularly if it is stored in the canister as an emulsion or suspension, or to stick to the surfaces of the inhaler with which it makes contact, such as the inside of the canister.
  • the latter problem has been addressed with some measure of success by coating the inside of the canister with PTFE or other non-stick compounds.
  • the former problem has been addressed by including in the formulation of drug and propellant a surfactant of an appropriate kind.
  • the surfactant can help to keep the droplets of an emulsion stable, to prevent droplets of the drug from adhering to the walls of the canister or to one another and can also act as a lubricant for the valve stem.
  • valve assembly of this kind is the subject of international patent application no. PCT/GB88/00197.
  • the top of the metering chamber is defined by the seal in the upper, second vent.
  • the valve stem as illustrated in this document includes a relatively large sealing flange that covers a substantial portion of the upper seal when the valve stem is in its extended position, the size of the metering chamber is only defined once the stem has been partially depressed to a position at which its lower end makes sealing contact with the lower, first vent. At that position, the stem flange is clear of the upper seal and the upper boundary of the metering chamber is therefore defined by the seal.
  • a first aspect of the present invention provides a valve assembly for a metered dose dispenser comprising: a metering chamber having a wall that is adapted to form a common boundary between the metering chamber and a pressurised storage reservoir to which it is to be attached and in which the boundary wall includes a first vent that allows the metering chamber to communicate with the storage reservoir and an opposing wall of the meter- ing chamber includes a second vent, the first and second vents including first and second seals respectively; a valve stem that is movable via the second vent, in sealing contact with the second seal, between depressed positions in which the inside of the metering chamber is in communication with the outside via the valve stem and extended positions in which the inside of the metering chamber is isolated from the outside; in which movement of the valve stem through its extended positions to its depressed positions causes sealing contact with the first seal, thus closing
  • the seals lie outside the metering chamber, that is to say they play no palpable part in defining the volume of the metering chamber. Therefore, even if the material from which the seals are made does creep as it ages, this will not affect the volume of the metering chamber.
  • the surface area of the metering chamber is in part provided by the insert, in part by the stem and in part by the seals, owing to the necessary clearances between the stem and the insert.
  • the proportion of the surface area provided by the seals should be as low as possible. In the present invention, it is preferred that this proportion be no greater than 10%, but for best effect it should be no greater than 5%. As the lower limit defined by the necessary clearances between the stem and the insert is approached, a proportion of 2% or less can be achieved.
  • the insert should be structurally rigid and dimensionally stable. It is also very important that the volume of the metering chamber can be accurately and consistently defined during the manufacturing proc- ess. This can be achieved with a metallic insert, for example one formed from stainless steel, since metal can be formed to very tight tolerances, by conventional deep- drawing or rolling processes. Alternatively, a suitable engineering plastic could be used.
  • the insert may be a one piece insert. If metallic, it may be deep-drawn to form sides and base and then rolled to form the top. Alternatively it may be cast or moulded using a sacrificial core. These manufacturing techniques are complex or expensive.
  • the insert may be in two pieces with, for example, a dish-shaped base and an inverted dish-shaped top. Either could be made by deep-drawing, or conventional casting or moulding, but there will be a line of leakage where the two parts meet at the waist of the insert. This may not necessarily be a problem so long as the two parts are accurately manufactured and located.
  • the amount of stress to which the seals need to be sub- jected can be minimised if the main body of the valve assembly has a cavity within which the insert is positioned and in which the first and second seals are positioned between the outer surface of the insert and the inner surfaces of the cavity. This can accurately locate the seals ensuring a good seal at lower levels of applied stress .
  • valve stem boundary characteristics can be achieved by coating the valve stem with a friction-reducing coating, for example a coating of bonded fluoropolymer , silicones or fluoro-silicones .
  • a friction-reducing coating for example a coating of bonded fluoropolymer , silicones or fluoro-silicones .
  • materials for use in a suitable application process are aqueous suspensions of PTFE, PVDF or PFA.
  • the present invention further provides a valve assembly for a metered dose dispenser comprising: a metering chamber having a wall that is adapted to form a common boundary between the metering chamber and a pressurised storage reservoir to which it is to be attached and in which the boundary wall includes a first vent that allows the metering chamber to communicate with the storage reservoir and an opposing wall of the metering chamber includes a second vent, the first and second vents including first and second seals respectively; a valve stem that is movable via the second vent, in sealing contact with the second seal, between depressed positions in which the inside of the metering chamber is in communication with the outside via the valve stem and extended positions in which the inside of the metering chamber is isolated from the outside; in which movement of the valve stem through its extended positions to its depressed positions causes sealing contact with the first seal, thus closing the first vent, before the stem reaches the threshold between its extended and depressed positions; and the valve stem includes a friction-reducing coating applied to at least those parts of it that contact the first and/or second
  • Metered dose inhalers conventionally require a spring ' to bias the valve stem back to its extended positions once it has been depressed to dispense a dose of drug product.
  • the conventional positioning of such springs has left them prone to attract deposits of the drug product. Uniformity of dosing is compromised when the active drug is deposited, then later released.
  • the spring can suffer corrosion. Both factors can lead to poor quality of operation of the valve stem, which may result in incomplete dosing. It can also interfere with the free flow of drug product out of the device.
  • figure 1 show just such an arrangement, in which the spring 34 acts between a cup 36, in which the closed end 26 of the valve stem 20 is received, and the base 38 of a perforated cage 40. It is permanently exposed to drug product within the pressurised canister.
  • a second aspect of the present invention provides a valve assembly for a metered dose dispenser comprising: a metering chamber having a wall that is adapted to form a common boundary between the metering chamber and a pressurised storage reservoir to which it is to be attached and in which the boundary wall includes a vent that allows the metering chamber to communicate with the storage reservoir; and a valve stem that is movable between depressed positions in which the inside of the metering chamber is in communication with the outside to allow product to be dispensed from the metering chamber via the valve stem and extended positions in which the inside of the metering chamber is isolated from the outside; in which movement of the valve stem through its extended positions to its depressed positions closes the vent before the stem reaches the threshold between its extended and depressed positions; and a spring is provided acting between
  • a suitable arrangement would involve the use of a helical compression spring that surrounds the valve stem. This arrangement has advantages over and above those previ- ously identified, as will now be elaborated.
  • the valve assembly of a typical metered dose inhaler is attached to the pressurised canister by a ferrule of an appropriate form.
  • the ferrule includes an opening for passage of the valve stem and this overlies the second vent at the top of the metering chamber.
  • the ferrule must be raised, in the region of the opening, to form a crown that makes room for the spring. This, ensures that the ferrule encapsulates the spring, protecting it from the environment, but also means that there are now three openings through which the valve stem must pass: the first and second vents and the opening in the ferrule, all of which are spaced apart from one another. This substantially reduces the incidence of side streaming, since the extent to which the valve stem can lever against the seals is limited by the opening in the fer- rule.
  • valve assembly of the second aspect of the present invention should include a ferrule for attaching the valve assembly to the storage reservoir, the ferrule including an opening for passage of the valve stem and being adapted, with the walls of the metering chamber, to encapsulate the helical compression spring.
  • Figure 1 is a conventional valve assembly for a metered dose inhaler
  • Figures 2-4 show essentially similar metered dose inhalers according to the present invention, of different nominal dosing volumes
  • Figure 5 shows a metered dose inhaler that uses a conical spring.
  • Figure 2 shows a metered dose inhaler according to the present invention having a nominal dose size of 100 ⁇ t .
  • the inhaler consists of a pressurised aluminium, stainless steel, glass or plastic canister 40 that acts as a reservoir for a drug product, upon which is mounted a valve assembly that acts as a metered dose dispenser, or metering valve.
  • An engineering plastic main body 42 of the valve assembly is located over the open end of the canister 40 and includes an annular recess 44 that provides a seat for an annular sealing ring 46.
  • the main body 42 is secured to the end of the canister 40 by a ferrule 48 or formable material, such as stainless steel, aluminium alloy or engineering plastic.
  • the ferrule 48 shown in figure 2 has been partially formed, but requires a further forming operation to conform to the exterior shape of the end of the canister 40, so as to secure the main body 42 in place.
  • the main body 42 includes a central, substantially cylindrical cavity that extends to the top of the main body 42, but not as far as the base.
  • a hole 50 in the base of the main body 42 is provided to form part of a first vent between the metering chamber 10 and the canister 40.
  • the base of the main body 42 provides a part of a boundary wall between the metering chamber 10 and the pressurised canister 40.
  • the remainder of the boundary wall is provided by a first seal 22 and an insert 52, which will be described later.
  • Both the hole 50 and an equivalent hole 54 in the base of the insert 52 are shown fluted. This is to aid rapid pressure filling of the canister.
  • the central, cylindrical cavity in the main body 42 of the valve assembly contains the first elastomeric seal 22, the insert 52 and a second elastomeric seal 24.
  • a thermoplastic bushing 56 Above the second seal 24 is a thermoplastic bushing 56.
  • the top of the insert 52, the second seal 24 and the bushing 56 constitute the upper wall of the metering chamber 10.
  • a hole 58 in the bushing 56 forms part of a second vent.
  • the volume of the metering chamber is defined almost wholly by the insert 52 and, of course, the valve stem 20.
  • the insert 52 is a bare clearance fit within the cavity in the main body 42, so is accurately positioned within it.
  • the seals effectively lie outside the metering chamber and play no palpable part in defining the volume of the metering chamber. Therefore, even if the material from which the seals are made does creep as it ages, this will not affect the volume of the metering chamber.
  • the insert 52 provides about 80% of the surface area of the metering chamber. About 18% of the surface area is provided by the stem 20 and about 2% by the seals 22, 24.
  • the insert is shown as a one piece insert. It is formed from stainless steel, deep-drawn to form the sides and base and then rolled to form the top. Stainless steel is chosen because of its excellent rigidity and dimensional stability as compared with other materials, its strength and workability. It is very important that the volume of the metering chamber can be accurately and consistently defined during the manufacturing process. This can be achieved with stainless steel, since it is easy to work to very tight tolerances, by conventional drawing or rolling processes.
  • Stainless steel is the preferred material, but other materials can be used to ensure that the volume of the metering cavity remains constant under different conditions and throughout the life of the device.
  • a suitable engineering plastics could be used instead of stainless steel.
  • the first and second seals 22, 24 are positioned between the outer surface of the insert 52 and the inner surfaces of the cavity in the main body (for which purpose the bushing 56 is regarded as apart of the main body 42) . This accurately locates the seals ensuring a good seal at levels of applied stress lower than is conventional. These lower levels of stress help to ensure that the likelihood of the valve stem sticking to the seals, or not operating as smoothly as would be desired, because of friction is reduced.
  • valve stem 20 which bears against the seals 22, 24.
  • the valve stem 20 is formed from deep-drawn stainless steel into the form of a tube that is closed at its lower, innermost end 26 and open at its upper, outermost end 28 and includes a side hole 30 communicating between the inside and the outside of the valve stem 20 and one or more indented channels 32 to- wards its lower end 26 that interrupt its normally circular cross-section.
  • a further improvement of the seal-stem boundary characteristics can be achieved by coating the valve stem with a friction-reducing coating, for example a coating of bonded fluoropolymer, silicones or fluoro- silicones. Examples of materials for use in a suitable application process are aqueous suspensions of PTFE, PVDF or PFA.
  • the valve stem includes a crimped waist 60 that forms an abutment for one end of a helical compression spring 62, the other end of which bears against the bushing 56.
  • the ferrule 48 is formed into a crown 64 through which the open end 28 of the valve stem 20 passes.
  • the opening in the crown 64 is smaller than the waist 60 of the valve stem, preventing it from coming free. Accordingly, the ferrule 48 and the bushing 56 encapsulate the spring, protecting it from the environment,
  • the crown 64 of the ferrule 48 provides a third openings through which the valve stem must pass: the first and second vents and the opening in the ferrule. All these openings are spaced apart from one another. This substantially reduces the incidence of side-streaming, since the extent to which the valve stem can lever against the seals is limited by the opening in the ferrule, combined with those of the bushing and the lower vent.
  • a conical compression spring could be used as opposed to a helical spring.
  • the coils of a conical spring are obliged to nest within one another as the conical spring is compressed. If adjacent coils contact one another, this can help to stabilise and centre the valve stem 20 over the second vent, further reducing the likelihood of side-streaming.
  • An inhaler that uses a conical spring is illustrated in figure 5. As can be seen from this figure, depression of the valve stem will result in adjacent coils of the spring nesting within one another.
  • the valve stem 20 is normally in an elevated or extended position as shown in figure 2, in which the channel 32 is located within the first vent and allows the canister 40 to communicate with the metering chamber 10. This primes the metering chamber 10.
  • the valve stem 20 is depressed against the bias of the spring 62, firstly the channel 32 moves below the seal 22 in the first vent, isolating the canister 40 from the metering chamber 10.
  • the side hole 30 moves below the seal 24 in the second vent, allowing the metering chamber 10 to communicate with the outside via the side hole 30 and the open end 28 of the valve stem 20.
  • Movement of the valve stem is arrested by complete compression of the spring 62 causing its coils to contact one another.
  • Figure 3 shows an inhaler similar to that of figure 2, but is designed to a nominal dose size of 50 ⁇ t .
  • the hollow insert 52 is smaller, the seals 22, 24 are smaller in outer diameter and the bushing 56 is replaced by a sleeve 66.
  • the Sleeve sits between the outside diameter of the insert 52 and the inside diameter of the cavity within the main body 42, ensuring that the smaller insert 52 is accurately located.
  • the sleeve 66 also provides a seat for the pouter diameters of the seals 22, 24, retains the upper seal 24 in place and provides a bearing surface for the lower end of the spring 62.
  • the insert 52 provides about 65% of the surface area of the metering chamber. About 33% of the surface area is provided by the stem 20 and about 2% by the seals 22, 24.
  • Figure 4 shows an inhaler essentially similar to that of figure 3, but with a nominal dose size of 25 ⁇ l . It has a yet smaller insert 52, smaller seals 22, 24 and a thicker sleeve 66. In figure 4, the insert 52 provides about 55% of the surface area of the metering chamber. About 43% of the surface area is provided by the stem 20 and about 2% by the seals 22, 24.

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  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention concerne un assemblage de soupape utilisé dans un distributeur de doses. Une chambre de dosage et un réservoir de stockage sous pression possèdent une paroi de séparation comportant un premier évent. Une paroi opposée de cette chambre de dosage est dotée d'un second évent. Chacun des ces évents est pourvu d'un joint. Une tige de soupape peut se déplacer via un second évent entre des positions restreintes dans lesquelles l'intérieur de la chambre de dosage communique avec l'extérieur, via la tige de soupape et des positions étendues dans lesquelles la chambre ne communique pas. Le mouvement de la tige de soupape de ses positions étendues à ses positions restreintes ferme le premier évent, avant que la tige n'atteigne le seuil entre ses positions étendues et ses positions restreintes. Les limites de la chambre de dosage sont précisément définies par le corps principal de l'assemblage de soupape. Les premier et second joints sont placés entre la surface extérieure de l'insert et la surface intérieure de la cavité. Un ressort de compression surmontant la tige de manoeuvre agit entre l'extérieur de la chambre de dosage et l'extérieur de la tige de soupape, en vue d'orienter la tige de soupape vers ses positions étendues. En conséquence, le produit de la chambre de dosage n'entre pas en contact avec le ressort car il est distribué par la tige de soupape. Une virole fixe l'assemblage de soupape au réservoir de stockage et comprend une ouverture pour laisser passer la tige de soupape. La virole encapsule le ressort de compression et contribue à réduire le flot secondaire.
PCT/GB2001/001692 2000-04-14 2001-04-17 Assemblage de soupape pour des distributeurs de doses Ceased WO2001079079A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/240,770 US20040222244A1 (en) 2000-04-14 2001-04-17 Valve assembly for metered dose dispensers
AU93375/01A AU9337501A (en) 2000-04-14 2001-04-17 Valve assembly for metered dose dispensers
EP01969039A EP1272401A1 (fr) 2000-04-14 2001-04-17 Assemblage de soupape pour des distributeurs de doses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0009141.3 2000-04-14
GB0009141A GB2361229A (en) 2000-04-14 2000-04-14 Metering valve

Publications (1)

Publication Number Publication Date
WO2001079079A1 true WO2001079079A1 (fr) 2001-10-25

Family

ID=9889855

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/001692 Ceased WO2001079079A1 (fr) 2000-04-14 2001-04-17 Assemblage de soupape pour des distributeurs de doses

Country Status (5)

Country Link
US (1) US20040222244A1 (fr)
EP (1) EP1272401A1 (fr)
AU (1) AU9337501A (fr)
GB (1) GB2361229A (fr)
WO (1) WO2001079079A1 (fr)

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WO2011012804A1 (fr) 2009-07-30 2011-02-03 Valois Sas Valve de distribution de produit fluide
WO2012072962A1 (fr) 2010-12-03 2012-06-07 Valois Sas Valve de distribution de produit fluide.
WO2018149472A1 (fr) 2017-02-14 2018-08-23 Presspart Gmbh & Co. Kg Procédé d'assemblage étanche d'une cartouche et d'un couvercle supérieur

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GB2401914B (en) * 2000-11-10 2005-03-16 Valois Sa Valve gasket and the process of its manufacture
FR2816688B1 (fr) * 2000-11-10 2003-02-14 Valois Sa Joint de valve et son procede de fabrication
FR2831876B1 (fr) * 2001-11-07 2004-04-23 Valois Sa Pompe de distribution de produit fluide
GB2401099A (en) * 2003-04-30 2004-11-03 Bespak Plc Improvements in valves for pressurised dispensing containers
BRPI0409812A (pt) 2003-04-30 2006-05-09 Bespak Plc válvula de medição
GB0309936D0 (en) * 2003-04-30 2003-06-04 Bespak Plc Improvements in valves for pressurised dispensing containers
GB2402667A (en) * 2003-06-10 2004-12-15 Bespak Plc Dispensing device
GB2417480B (en) * 2004-12-15 2006-08-02 Bespak Plc Improvements in or relating to valves
US8227027B2 (en) * 2007-12-07 2012-07-24 Presspart Gmbh & Co. Kg Method for applying a polymer coating to an internal surface of a container
FR2973786B1 (fr) * 2011-04-06 2014-07-04 Valois Sas Bague pour dispositif de distribution de produit fluide.
WO2013019784A1 (fr) * 2011-08-01 2013-02-07 Graham Packaging Company Lp Contenant aérosol en plastique et son procédé de fabrication
US20130082074A1 (en) * 2011-10-03 2013-04-04 Graham Packaging Company, L.P. Plastic aerosol container assembly and method of making
JP6049168B2 (ja) * 2012-07-31 2016-12-21 株式会社三谷バルブ 定量噴射機構およびこの定量噴射機構を備えたエアゾール式製品
US9554981B2 (en) 2012-09-14 2017-01-31 The Procter & Gamble Company Aerosol antiperspirant compositions, products and methods
US9662285B2 (en) 2014-03-13 2017-05-30 The Procter & Gamble Company Aerosol antiperspirant compositions, products and methods
US9579265B2 (en) 2014-03-13 2017-02-28 The Procter & Gamble Company Aerosol antiperspirant compositions, products and methods
PE20180360A1 (es) * 2015-04-01 2018-02-21 Graham Packaging Co Estructura y metodo de sellado de un montaje de cierre en el acabado del cuello de un contenedor de plastico a presion
GB201600894D0 (en) 2016-01-18 2016-03-02 Obrist Closures Switzerland Dispensing closure
GB201702406D0 (en) * 2017-02-14 2017-03-29 Norton (Waterford) Ltd Inhalers and related methods

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WO1988007010A1 (fr) * 1987-03-13 1988-09-22 Riker Laboratories, Inc. Valve pour aerosol
WO1999042154A1 (fr) * 1998-02-23 1999-08-26 Bespak Plc Dispositifs d'administration de medicaments

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US3058629A (en) * 1959-02-05 1962-10-16 Neotechnic Eng Ltd Dispensing devices for aerosols
FR1287373A (fr) * 1960-11-22 1962-03-16 Perfectionnements aux valves doseuses
US3178078A (en) * 1961-12-29 1965-04-13 Sterling Drug Inc Metered valve construction
US3394851A (en) * 1965-09-20 1968-07-30 Sterling Drug Inc Metered aerosol valve for use with compressed gas
GB2178398A (en) * 1985-07-17 1987-02-11 Bespak Plc Metering valve for pressurised dispensing containers
WO1988007010A1 (fr) * 1987-03-13 1988-09-22 Riker Laboratories, Inc. Valve pour aerosol
WO1999042154A1 (fr) * 1998-02-23 1999-08-26 Bespak Plc Dispositifs d'administration de medicaments

Cited By (7)

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Publication number Priority date Publication date Assignee Title
WO2011012804A1 (fr) 2009-07-30 2011-02-03 Valois Sas Valve de distribution de produit fluide
FR2948645A1 (fr) * 2009-07-30 2011-02-04 Valois Sas Valve de distribution de produit fluide
CN102470970A (zh) * 2009-07-30 2012-05-23 瓦卢瓦有限合伙公司 流体产品分配阀
WO2012072962A1 (fr) 2010-12-03 2012-06-07 Valois Sas Valve de distribution de produit fluide.
FR2968283A1 (fr) * 2010-12-03 2012-06-08 Valois Sas Valve de distribution de produit fluide.
CN103328346A (zh) * 2010-12-03 2013-09-25 阿普塔尔法国简易股份公司 流体产品分配阀
WO2018149472A1 (fr) 2017-02-14 2018-08-23 Presspart Gmbh & Co. Kg Procédé d'assemblage étanche d'une cartouche et d'un couvercle supérieur

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US20040222244A1 (en) 2004-11-11
GB2361229A (en) 2001-10-17
AU9337501A (en) 2001-10-30
GB0009141D0 (en) 2000-05-31
EP1272401A1 (fr) 2003-01-08

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