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WO2001077320A3 - Regulation du recepteur couple aux proteines g humain du type hm74 - Google Patents

Regulation du recepteur couple aux proteines g humain du type hm74 Download PDF

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Publication number
WO2001077320A3
WO2001077320A3 PCT/EP2001/003811 EP0103811W WO0177320A3 WO 2001077320 A3 WO2001077320 A3 WO 2001077320A3 EP 0103811 W EP0103811 W EP 0103811W WO 0177320 A3 WO0177320 A3 WO 0177320A3
Authority
WO
WIPO (PCT)
Prior art keywords
asthma
coupled receptor
disease
protein coupled
diseases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2001/003811
Other languages
English (en)
Other versions
WO2001077320A2 (fr
Inventor
Yonghong Xiao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to AU2001246526A priority Critical patent/AU2001246526A1/en
Priority to EP01919423A priority patent/EP1272631A2/fr
Publication of WO2001077320A2 publication Critical patent/WO2001077320A2/fr
Publication of WO2001077320A3 publication Critical patent/WO2001077320A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des réactifs qui régulent le récepteur couplé aux protéines G humain du type HM74 et qui peuvent contribuer à prévenir, améliorer ou corriger des dysfonctionnements ou des maladies y compris, de manière non limitative, des infections telles que les infections bactériennes, fongiques, les infections causées par des protozoaires et les infections virales, en particulier les infections causées par le VIH, la douleur, les cancers, l'anorexie, la boulimie, l'asthme, les maladies du système nerveux central telles que la maladie de Parkinson, les maladies cardiovasculaires telles que l'insuffisance cardiaque aiguë, l'hypotension, l'hypertension, l'angine de poitrine et l'infarctus du myocarde, la rétention urinaire, l'ostéoporose, les ulcères, les inflammations, les allergies, la sclérose en plaques, l'hypertrophie bénigne de la prostate, ainsi que les troubles psychotiques et neurologiques, y compris l'anxiété, la schizophrénie, les troubles bipolaires, les délires, la démence, diverses arriérations mentales et les dyskinésies telles que la chorée de Huntington et le syndrome de Gilles de la Tourette.
PCT/EP2001/003811 2000-04-05 2001-04-04 Regulation du recepteur couple aux proteines g humain du type hm74 Ceased WO2001077320A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001246526A AU2001246526A1 (en) 2000-04-05 2001-04-04 Regulation of human hm74-like g protein coupled receptor
EP01919423A EP1272631A2 (fr) 2000-04-05 2001-04-04 Regulation du recepteur couple aux proteines g humain du type hm74

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19470100P 2000-04-05 2000-04-05
US60/194,701 2000-04-05

Publications (2)

Publication Number Publication Date
WO2001077320A2 WO2001077320A2 (fr) 2001-10-18
WO2001077320A3 true WO2001077320A3 (fr) 2002-03-14

Family

ID=22718593

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/003811 Ceased WO2001077320A2 (fr) 2000-04-05 2001-04-04 Regulation du recepteur couple aux proteines g humain du type hm74

Country Status (3)

Country Link
EP (1) EP1272631A2 (fr)
AU (1) AU2001246526A1 (fr)
WO (1) WO2001077320A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2388865A1 (fr) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Recepteurs couples a une proteine g
WO2001074904A2 (fr) * 2000-03-31 2001-10-11 Curagen Corporation Nouvelles proteines et acides nucleiques codant pour celles-ci
US20020052022A1 (en) * 2000-05-30 2002-05-02 Nabil Elshourbagy Molecular cloning of a chemokine like 7TMR (AXOR87)
US6902902B2 (en) 2001-11-27 2005-06-07 Arena Pharmaceuticals, Inc. Human G protein-coupled receptors and modulators thereof for the treatment of metabolic-related disorders
US7189524B1 (en) 2002-11-25 2007-03-13 Amgen, Inc. Receptor ligands and methods of modulating receptors
EP1597586A2 (fr) * 2003-02-13 2005-11-23 Bayer HealthCare AG Agents de diagnostic et de traitement destines aux maladies associees a hm74 (hm74)
SG163577A1 (en) 2004-12-03 2010-08-30 Schering Corp Substituted piperazines as cb1 antagonists
CN101208082A (zh) 2005-06-28 2008-06-25 默克公司 烟酸受体激动剂、含有所述化合物的组合物和治疗方法
WO2008063321A2 (fr) 2006-10-13 2008-05-29 Janssen Pharmaceutica N.V. Complexes gpr81-ligand; fabrication et utilisation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0578962A2 (fr) * 1992-07-17 1994-01-19 American Cyanamid Company Procédé pour identifier un récepteur
WO1998056820A1 (fr) * 1997-06-12 1998-12-17 Smithkline Beecham Corporation Recepteur hm74a
WO2001036473A2 (fr) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Recepteurs couples a une proteine g
WO2001036471A2 (fr) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Versions endogenes et non-endogenes de recepteurs couples a la proteine g humaine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074904A2 (fr) * 2000-03-31 2001-10-11 Curagen Corporation Nouvelles proteines et acides nucleiques codant pour celles-ci

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0578962A2 (fr) * 1992-07-17 1994-01-19 American Cyanamid Company Procédé pour identifier un récepteur
WO1998056820A1 (fr) * 1997-06-12 1998-12-17 Smithkline Beecham Corporation Recepteur hm74a
WO2001036473A2 (fr) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Recepteurs couples a une proteine g
WO2001036471A2 (fr) * 1999-11-17 2001-05-25 Arena Pharmaceuticals, Inc. Versions endogenes et non-endogenes de recepteurs couples a la proteine g humaine

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 23 March 2000 (2000-03-23), MUZNY, D.M., ET AL.: "Homo sapiens chromosome 12 clone RP11-324E6, WORKING DRAFT SEQUENCE, 13 unordered pieces.", XP002180536 *
DATABASE EMBL 23 March 2000 (2000-03-23), MUZNY, D.M., ET AL.: "Homo sapiens chromosome 12 clone RP11-507N20, WORKING DRAFT SEQUENCE, 10 unordered pieces.", XP002180537 *
DATABASE EMBL 3 April 2001 (2001-04-03), WANG, Y., ET AL.: "Homo sapiens putative chemokine receptor (FKSG80) mRNA, complete cds.", XP002180538 *
See also references of EP1272631A2 *

Also Published As

Publication number Publication date
WO2001077320A2 (fr) 2001-10-18
EP1272631A2 (fr) 2003-01-08
AU2001246526A1 (en) 2001-10-23

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