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WO2001071341A1 - Dispositif auxiliaire d'introduction d'echantillons - Google Patents

Dispositif auxiliaire d'introduction d'echantillons Download PDF

Info

Publication number
WO2001071341A1
WO2001071341A1 PCT/JP2001/002263 JP0102263W WO0171341A1 WO 2001071341 A1 WO2001071341 A1 WO 2001071341A1 JP 0102263 W JP0102263 W JP 0102263W WO 0171341 A1 WO0171341 A1 WO 0171341A1
Authority
WO
WIPO (PCT)
Prior art keywords
sample
hole
liquid
sample supply
view
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2001/002263
Other languages
English (en)
Japanese (ja)
Inventor
Yoshiyuki Tanaka
Yuichiro Noda
Konomu Hirao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arkray Inc
Original Assignee
Arkray Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arkray Inc filed Critical Arkray Inc
Publication of WO2001071341A1 publication Critical patent/WO2001071341A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/565—Seals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details

Definitions

  • the present invention relates to a sample supply assisting device used for supplying a sample to a sample analysis device.
  • sample analysis tools used up for each test are widely used.
  • An example of this is shown in FIG.
  • (A) is a plan view
  • (B) is a cross-sectional view as viewed in the V-V direction of the plan view
  • (C) is a perspective view.
  • the sample analysis device 3 is configured by storing a porous sheet 32 such as filter paper in a flat rectangular parallelepiped container 31, and one end of the upper surface of the container 31. Further (from the left in the figure), a hole 33 for sample introduction is formed.
  • the sample analysis tool 3 when a sample such as blood is spotted on the porous sheet 32 from the hole 33, the sample expands inside the porous sheet 32 by capillary action.
  • the arrow in the same figure (B) indicates the direction in which the specimen is developed.
  • the components in the sample are separated by the chromatographic effect. For example, in whole blood, blood cells are separated from plasma and serum.
  • an analytical reagent or the like is held on the porous sheet, this reacts with a component in the sample, and the separation is performed by optical means or electrochemical means.
  • the sample analysis device is used for holding or storing the sample, and in this case, the liquid sample is held or stored in a dry state. . Soshi Then, after a certain period of time from the sampling, the porous sheet is taken out from the sample analysis tool, and plasma and serum are extracted therefrom for analysis.
  • an object of the present invention is to provide a sample supply assisting device that can easily and accurately supply a sample to a sample supply unit of the sample analyzing device. Disclosure of the invention
  • a sample analysis tool of the present invention is a sample supply auxiliary tool used when a sample is supplied to a sample analysis tool, and has a through-hole.
  • the sample is supplied to a tool, and the hole diameter of the through-hole is larger on the sample introduction side than on the sample outlet side.
  • the sample supply aid of the present invention is attached to the sample supply section of the sample analysis tool. If this is the case, the target for supplying the sample is increased, and the sample can be supplied easily and accurately.
  • the sample is capable of moving inside the porous sheet due to, for example, capillary action, and is not limited to a liquid sample, and may be, for example, a sol sample.
  • Samples applicable to the present invention include, for example, whole blood, plasma, serum, urine, bone marrow fluid, saliva, semen, and other secretions.
  • a liquid absorbing means is provided inside the through hole.
  • the liquid absorbing means even if an excessive sample is supplied, it can be prevented from overflowing and contaminating the sample analysis tool. Further, by adjusting the arrangement position of the liquid absorbing means, it is possible to adjust the liquid level of the sample, so that the sample can be supplied quantitatively.
  • liquid absorbing means for example, a liquid absorbing member is disposed inside the through-hole, or there is a capillary communicating with the inside of the through-hole or a gap where a capillary phenomenon occurs.
  • the liquid-absorbent member may be provided with a concave portion on the inner wall of the through-hole and disposed here.
  • the material of the liquid absorbing member is not particularly limited, and examples thereof include cellulose, nitrocellulose, glass fiber, polyester, polysulfone, and PVDF (polypinylidene fluoride). And glass fiber are preferred, and cellulose is more preferred. It is preferable that the capillary and the gap where the capillary phenomenon occurs have an air vent hole. This is because strong capillarity occurs if air vent holes are provided.
  • the cross-sectional shape of the through-hole may be, for example, a shape extending in a tapered manner from the sample outlet side or from the middle thereof to the sample inlet side. Since this shape is similar to the shape of the so-called filter, the sample supply becomes easier and more accurate.
  • the inner surface of the through hole is hydrophobic and Preferably, it is oleophobic. This is because the sample can be prevented from adhering to such an inner surface.
  • FIG. 1 (A) is a plan view showing an example of the sample supply aid of the present invention
  • FIG. 1 (B) is a cross-sectional view of the above example
  • FIG. 1 (C) is a perspective view of the above example
  • FIG. 2 (A) is a plan view showing an example of the liquid-absorbing member of the present invention
  • FIG. 2 (B) is a front view of the above-mentioned example
  • FIG. FIGS. 3 (A) and (B) are perspective views showing another example of the liquid-absorbing member of the present invention
  • FIG. 4 (A) is a sample supply aid of the above example.
  • FIG. 6B is a plan view
  • FIG. 6B is a cross-sectional view of the example
  • FIG. 6C is a perspective view of the example
  • FIG. 6A is a sample supply aid of the present invention.
  • FIG. 7B is a cross-sectional view of the example
  • FIG. 7C is a perspective view of the example
  • FIG. 7A is a plan view of an example of a sample analysis tool.
  • FIG. 2B is a cross-sectional view of the above example.
  • FIG. 2C is a perspective view of the above example.
  • FIG. 1 shows an example of the sample supply aid of the present invention.
  • (A) is a plan view
  • (B) is a cross-sectional view as viewed in the direction I-I of the plan view
  • (C) is a perspective view. Same sign It is attached.
  • the sample supply auxiliary tool 1 has a substantially disk shape, and a through hole 13 is formed in the center thereof.
  • the cross-sectional shape of the through-hole 13 is a shape that expands in a tapered shape from below to above, and 14 denotes one surface of the taper.
  • a concave portion 11 is formed in a part of the tapered surface 14, and a liquid-absorbing member is arranged here.
  • a protrusion 15 on the ring is formed integrally around the through hole 13 so as to surround it.
  • 1 2 shows a part.
  • the size of the tool is not particularly limited, and is appropriately determined according to conditions such as the size of the sample analysis tool to be applied. For example, diameter 15 ⁇ 60mm, thickness 1.5 ⁇ 6mm, maximum diameter of through hole 10 ⁇ 30mm, minimum diameter of through hole 3 ⁇ 1.0mm, maximum width of recess 2 ⁇ 20mm, The maximum length of the recess is 5 to 20 mm, and the depth of the recess is 1 to 4 mm.
  • the diameter is 20 to 40 mm
  • the thickness is 2 to 4 mm
  • the maximum diameter of the through hole is 12 to 25 mm
  • the minimum diameter of the through hole is 4 to 8 mm
  • the maximum width of the recess is 3 to 15 mm
  • the maximum length of the recess is The depth is 6 to 15 mm and the depth of the recess is 1.5 to 3.5 mm.
  • the diameter is 25 to 35 mm
  • the thickness is 2.5 to 3.5 mm
  • the minimum diameter of the through hole is 5 to 7 rnm
  • the maximum width of the recess is 5-1.
  • the depth of the recess is 0mm
  • the maximum length of the recess is 7-9mm
  • the depth of the recess is 2-3mm.
  • the material of the tool is not particularly limited, but as described above, the inner surface of the through-hole is preferably hydrophobic and oleophobic, and thus a material having such properties is preferable.
  • fluororesins such as PTFE (tetrafluoroethylene resin) and PCTFE (trifluoroethylene chloride resin), polyethylene and propylene mixed with silicon oil in the range of 5 to 15% by weight. There is. Of these, preferred are 10% by weight silicon-containing polypropylene and PTFE. PTFE is more preferable.
  • fluorine coating may be used.
  • the fluorine coating may be, for example, a Teflon resin (trade name), a fluorinated siloxane, etc. on the inner surface of the through hole. Is to coat the u.
  • FIG. 2 shows an example of the liquid absorbing member.
  • (A) is a plan view
  • (B) is a front view
  • (C) is a perspective view, in which the same parts are denoted by the same reference numerals.
  • the liquid absorbing member 2 has a shape (a wide crescent shape) corresponding to the shape of the concave portion of the tool.
  • This size is appropriately determined according to the size of the recess.
  • the maximum length is 4 to 20 mm
  • the maximum width is 1.5 to 18 mm
  • the maximum thickness is 0.5 to 2 mm.
  • the maximum length is 6 to 12 mm
  • the maximum width is 4 to 12 mm
  • the maximum thickness is 0.7 to 5 mm. More preferably, the maximum length? ⁇ 9mm, maximum width? ⁇ 10mm, maximum thickness 0.9 ⁇ 1.2mm.
  • the material of the liquid-absorbing member is as described above.
  • the shape of the liquid-absorbing member is not particularly limited.
  • the liquid-absorbing member may have a rectangular shape (a rectangular parallelepiped) as shown in FIG. You may.
  • the liquid absorbing ability of the liquid absorbing member is suitably from 30 to 100 It 1 in terms of the amount of water.
  • FIG. 4 shows an example in which the liquid-absorbing member 2 is attached to the sample-analyzing device 3 (see FIG. 7) with the sample-supply-sleeve assisting tool 1 in which the concave portion 11 of the through hole 13 is disposed.
  • (A) is a cross-sectional view
  • (B) is a perspective view, in which the same parts are denoted by the same reference numerals.
  • FIG. 1, FIG. 2, FIG. 4 and FIG. I have.
  • the protrusion 15 of the sample supply auxiliary tool 1 is fitted into the hole 33 of the sample analysis tool 3, and the two are connected. Then, the user only has to insert the sample into the hole 13 of the sample supply aid 1 and the mouth is large, so that the sample can be easily and accurately transferred to the predetermined area of the porous sheet 3 2 of the sample analysis tool 3. Can be supplied to the supply unit. Further, the liquid absorbing member 2 can prevent overflow of the sample even if an excessive sample is supplied. Further, as described above, by adjusting the height of the arrangement of the liquid-absorbing member, it is possible to supply the sample quantitatively. Furthermore, the sample absorbed by the liquid absorbing member can be subjected to another analysis, in which case the sample is effectively used.
  • sample supply auxiliary tool 1 is removed, and only the sample analysis tool 3 is used for analysis. Further, in the remote clinical test system, only the sample analysis tool 3 needs to be sent by mail, so that the mail is convenient without being bulky.
  • sample supply auxiliary tool of the present invention may be integrated with the sample analysis tool, or the sample auxiliary tool 1 and the sample analysis tool 3 may be separated after the sample is supplied.
  • FIG. 5 shows another example of the sample assisting device of the present invention.
  • (A) is a plan view
  • (B) is a cross-sectional view as seen in the direction of III-III of the above-mentioned plan view
  • (C) is a perspective view, in which the same parts are the same. It has a sign.
  • FIG. 5 the same parts as those in FIGS. 1 and 4 are denoted by the same reference numerals.
  • the tool 20 has a gap 21 communicating with the through hole 13 as a liquid absorbing means.
  • This gap is formed in a disk shape inside the tool main body, and has two air vent holes 22 open to the outside. like this
  • the sample assisting device has two donut-shaped members,
  • the gap width (height) of the gap 21 is not particularly limited, and is, for example, 10 to 300 m, preferably 50 to 150 m, and more preferably 100 to 100 m. im. Further, by adjusting the height of the gap 21, the amount of the supplied sample can be made constant. Other conditions and methods of use of the sample supply auxiliary device are the same as those in the above-described example.
  • FIG. 6 shows still another example of the sample assisting device of the present invention.
  • (A) is a plan view
  • (B) is a cross-sectional view of the above-mentioned plan view taken along the line IV-IV
  • (C) is a perspective view.
  • FIG. 6 the same parts as those in FIGS. 1 and 4 are denoted by the same reference numerals.
  • This tool 40 has eight capillary tubes 41 as liquid absorbing means. One end of each of these capillaries 41 communicates with the through hole 13, and extends radially around the through hole 13, and the other end is open to the outside. These capillaries 41 can be formed, for example, by piercing the tool body with a drill or the like.
  • the number of the capillary 41 is not particularly limited, and may be one, for example, 1 to 20, preferably 3 to 15, and more preferably 5 to 10.
  • the inner diameter of the capillary 41 is not particularly limited, and is, for example, 10 to 300 m, preferably 50 to 15011, and more preferably 100 to 1000 m. Further, by adjusting the arrangement position (height) of the capillary tube 41, the supplied sample amount can be made constant. Other conditions and the method of use of this sample supply aid are the same as those in the above-described example. Industrial applicability
  • the sample supply aid of the present invention even if the amount of the sample is very small, the sample can be easily and accurately supplied to the sample analysis device. Contribute to accurate testing in remote clinical testing systems.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention porte sur un dispositif auxiliaire (1) d'introduction d'échantillons dans un analyseur comportant un trou d'introduction (13) traversant dont le diamètre est plus grand à l'entrée qu'à la sortie, ce qui permet d'alimenter précisément et facilement l'analyseur.
PCT/JP2001/002263 2000-03-24 2001-03-22 Dispositif auxiliaire d'introduction d'echantillons Ceased WO2001071341A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000-84354 2000-03-24
JP2000084354 2000-03-24

Publications (1)

Publication Number Publication Date
WO2001071341A1 true WO2001071341A1 (fr) 2001-09-27

Family

ID=18600841

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/002263 Ceased WO2001071341A1 (fr) 2000-03-24 2001-03-22 Dispositif auxiliaire d'introduction d'echantillons

Country Status (1)

Country Link
WO (1) WO2001071341A1 (fr)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62228167A (ja) * 1985-10-04 1987-10-07 アボツト　ラボラトリ−ズ 固相分析装置及びその使用法
JPS63148978A (ja) * 1986-11-24 1988-06-21 アボット・ラボラトリーズ 固相分析装置用試料集束部材
JPS6438656A (en) * 1987-07-16 1989-02-08 Abbott Lab Reagent feeder for solid phase analysis
JPH01299464A (ja) * 1988-03-28 1989-12-04 Abbott Lab 固相分析装置
JPH06504621A (ja) * 1991-01-06 1994-05-26 オルジェニクス　リミテッド 流体の乾式化学分析用装置
JPH08506420A (ja) * 1993-04-30 1996-07-09 アボツト・ラボラトリーズ 改良された自動化学発光免疫検定装置

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62228167A (ja) * 1985-10-04 1987-10-07 アボツト　ラボラトリ−ズ 固相分析装置及びその使用法
JPS63148978A (ja) * 1986-11-24 1988-06-21 アボット・ラボラトリーズ 固相分析装置用試料集束部材
JPS6438656A (en) * 1987-07-16 1989-02-08 Abbott Lab Reagent feeder for solid phase analysis
JPH01299464A (ja) * 1988-03-28 1989-12-04 Abbott Lab 固相分析装置
JPH06504621A (ja) * 1991-01-06 1994-05-26 オルジェニクス　リミテッド 流体の乾式化学分析用装置
JPH08506420A (ja) * 1993-04-30 1996-07-09 アボツト・ラボラトリーズ 改良された自動化学発光免疫検定装置

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