[go: up one dir, main page]

WO2001070330A3 - Non-invasive body fluid sampling and analysis - Google Patents

Non-invasive body fluid sampling and analysis Download PDF

Info

Publication number
WO2001070330A3
WO2001070330A3 PCT/US2001/008489 US0108489W WO0170330A3 WO 2001070330 A3 WO2001070330 A3 WO 2001070330A3 US 0108489 W US0108489 W US 0108489W WO 0170330 A3 WO0170330 A3 WO 0170330A3
Authority
WO
WIPO (PCT)
Prior art keywords
body fluid
area
receiver
biological membrane
membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/008489
Other languages
French (fr)
Other versions
WO2001070330A2 (en
Inventor
Linda Custer
Tuan A Elstrom
Scott C Kellogg
Joseph Kost
Nicholas F Warner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sontra Medical Inc
Original Assignee
Sontra Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sontra Medical Inc filed Critical Sontra Medical Inc
Priority to US09/979,096 priority Critical patent/US7066884B2/en
Priority to AU45809/01A priority patent/AU781149B2/en
Priority to CA002374751A priority patent/CA2374751C/en
Priority to JP2001568521A priority patent/JP2003527613A/en
Priority to EP01918770A priority patent/EP1225831A2/en
Publication of WO2001070330A2 publication Critical patent/WO2001070330A2/en
Publication of WO2001070330A3 publication Critical patent/WO2001070330A3/en
Anticipated expiration legal-status Critical
Priority to US11/065,278 priority patent/US20060015058A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

A system, method, and device for non-invasive body fluid sampling is provided. According to one embodiment of the present invention, the system includes a controller that controls the generation of ultrasound; an ultrasonic applicator that applies the ultrasound to an area of biological membrane; a receiver that contacts the area of biological membrane and receives body fluid through and out of the area of biological membrane; and a meter that interacts with the receiver and detects the presence of at least one analyte in the body fluid in the receiver. The receiver may include a membrane and a medium, such as a hydrogel, a fluid, or a liquid, that is contained in the membrane. According to one embodiment of the present invention, the method includes the steps of (1) identifying an area of biological membrane having a permeability level; (2) increasing the permeability level of the area of biological membrane; (3) contacting the area of biological membrane with a receiver; (4) extracting body fluid through and out of the area of biological membrane; (5) providing an external force to enhance the body fluid extraction; (6) collecting the body fluid in the receiver; (7) analyzing the collected body fluid for the presence of at least one analyte; and (8) providing the results of the step of analyzing the body fluid.
PCT/US2001/008489 1998-01-08 2001-03-16 Non-invasive body fluid sampling and analysis Ceased WO2001070330A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US09/979,096 US7066884B2 (en) 1998-01-08 2001-03-16 System, method, and device for non-invasive body fluid sampling and analysis
AU45809/01A AU781149B2 (en) 2000-03-17 2001-03-16 System, method, and device for non-invasive body fluid sampling and analysis
CA002374751A CA2374751C (en) 2000-03-17 2001-03-16 System, method, and device for non-invasive body fluid sampling and analysis
JP2001568521A JP2003527613A (en) 2000-03-17 2001-03-16 Systems, methods and devices for non-invasive sampling and analysis of body fluids
EP01918770A EP1225831A2 (en) 2000-03-17 2001-03-16 Non-invasive body fluid sampling and analysis
US11/065,278 US20060015058A1 (en) 1998-01-08 2005-02-25 Agents and methods for enhancement of transdermal transport

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18997100P 2000-03-17 2000-03-17
US60/189,971 2000-03-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/065,278 Continuation-In-Part US20060015058A1 (en) 1998-01-08 2005-02-25 Agents and methods for enhancement of transdermal transport

Publications (2)

Publication Number Publication Date
WO2001070330A2 WO2001070330A2 (en) 2001-09-27
WO2001070330A3 true WO2001070330A3 (en) 2002-05-23

Family

ID=22699523

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/008489 Ceased WO2001070330A2 (en) 1998-01-08 2001-03-16 Non-invasive body fluid sampling and analysis

Country Status (5)

Country Link
EP (1) EP1225831A2 (en)
JP (2) JP2003527613A (en)
AU (1) AU781149B2 (en)
CA (1) CA2374751C (en)
WO (1) WO2001070330A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7066884B2 (en) 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
US7432069B2 (en) 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
US8870810B2 (en) 1998-12-18 2014-10-28 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US9572527B2 (en) 2007-04-27 2017-02-21 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery
US10390701B2 (en) 2016-11-17 2019-08-27 Samsung Electronics Co., Ltd. Apparatus and method for estimating biometric information

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ512367A (en) * 2001-06-14 2005-05-27 Horticulture & Food Res Inst Non-invasive transudate extraction
JP5502279B2 (en) * 2004-10-28 2014-05-28 エコー セラピューティクス， インコーポレイテッド System and method for analyte sampling and analysis using hydrogels
US20060094944A1 (en) * 2004-10-28 2006-05-04 Sontra Medical Corporation System and method for analyte sampling and analysis with error correction
JP2006167428A (en) * 2004-11-16 2006-06-29 Sysmex Corp Analyte extraction device, analyzer, analyte extraction method, and analysis method
WO2007144883A1 (en) 2006-06-13 2007-12-21 Ben Gurion University Of The Negev Research And Development Authority System and method for transfetal (amnion-chorion) membranes transport
CN101707875B (en) 2007-03-07 2014-09-17 回声治疗有限公司 Transdermal analyte monitoring systems and methods for analyte detection
JP2010266203A (en) * 2008-05-20 2010-11-25 Sony Corp Biological information acquisition method, biological information acquisition device, physiologically active substance measuring method, and physiologically active substance measuring device
EP2322093B1 (en) * 2008-07-31 2018-01-10 Sysmex Corporation Method for assaying in vivo component and apparatus and collection member for assaying in vivo component
EP2376059A2 (en) * 2008-11-25 2011-10-19 B.G. Negev Technologies and Applications Ltd. Pharmaceutical composition and system for permeabilizing fetal membranes
JP5406646B2 (en) * 2009-09-16 2014-02-05 シスメックス株式会社 Tissue fluid collection kit and tissue fluid collection sheet used for tissue fluid collection method
US20140243737A1 (en) * 2011-10-05 2014-08-28 Koninklijke Philips N.V. Assays for ultrasound mediated delivery
KR102673720B1 (en) 2016-07-29 2024-06-07 삼성전자주식회사 Apparatus and method for estimating substance in blood
KR102638309B1 (en) 2016-10-26 2024-02-19 삼성전자주식회사 Wearable device, and method for health monitoring
KR102681121B1 (en) 2016-11-15 2024-07-02 삼성전자주식회사 Apparatus and method for measuring biological components
CN115455629B (en) * 2021-06-08 2026-01-06 松堡投资有限公司 Stretch deformation electrode and biosensing system

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997004832A1 (en) * 1995-07-25 1997-02-13 Massachusetts Institute Of Technology Enhanced transdermal transport using ultrasound
WO1997030628A1 (en) * 1996-02-23 1997-08-28 Abbott Laboratories Enhanced transdermal transport of fluid using vacuum
WO1998000194A2 (en) * 1996-06-28 1998-01-08 Sontra Medical, L.P. Ultrasound enhancement of transdermal transport
US5722397A (en) * 1993-11-15 1998-03-03 Altea Technologies, Inc. Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
WO1999034858A1 (en) * 1998-01-12 1999-07-15 Georgia Tech Research Corporation Assessment and control of acoustic tissue effects
WO2000004821A1 (en) * 1998-07-21 2000-02-03 Spectrx, Inc. Fluid management in a continuous fluid collection and sensor device

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767402A (en) 1986-07-08 1988-08-30 Massachusetts Institute Of Technology Ultrasound enhancement of transdermal drug delivery
WO1989006989A1 (en) 1988-01-29 1989-08-10 The Regents Of The University Of California Iontophoretic non-invasive sampling or delivery device
US5139023A (en) * 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
AU2944995A (en) * 1994-06-24 1996-01-19 Cygnus, Inc. Iontophoretic sampling device and method
DK0840597T3 (en) * 1995-07-12 2004-01-26 Cygnus Therapeutic Systems hydrogel
US6002961A (en) 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
US5947921A (en) 1995-12-18 1999-09-07 Massachusetts Institute Of Technology Chemical and physical enhancers and ultrasound for transdermal drug delivery
US5735273A (en) * 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
US5895362A (en) * 1996-02-23 1999-04-20 Abbott Laboratories Transdermal transport using ultrasonic standing waves
ES2195151T3 (en) * 1996-06-18 2003-12-01 Alza Corp IMPROVEMENT OR SAMPLING DEVICE FOR TRANSDERMAL AGENTS.
CA2317777C (en) 1998-01-08 2005-05-03 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
US6587705B1 (en) * 1998-03-13 2003-07-01 Lynn Kim Biosensor, iontophoretic sampling system, and methods of use thereof
WO1999058190A1 (en) * 1998-05-13 1999-11-18 Cygnus, Inc. Collection assemblies for transdermal sampling system
JP2002542841A (en) 1998-12-18 2002-12-17 ソントラ・メディカル・インコーポレーテッド Method and apparatus for producing a homogeneous cavity that facilitates transdermal movement

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5722397A (en) * 1993-11-15 1998-03-03 Altea Technologies, Inc. Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
WO1997004832A1 (en) * 1995-07-25 1997-02-13 Massachusetts Institute Of Technology Enhanced transdermal transport using ultrasound
WO1997030628A1 (en) * 1996-02-23 1997-08-28 Abbott Laboratories Enhanced transdermal transport of fluid using vacuum
WO1998000194A2 (en) * 1996-06-28 1998-01-08 Sontra Medical, L.P. Ultrasound enhancement of transdermal transport
WO1999034858A1 (en) * 1998-01-12 1999-07-15 Georgia Tech Research Corporation Assessment and control of acoustic tissue effects
WO2000004821A1 (en) * 1998-07-21 2000-02-03 Spectrx, Inc. Fluid management in a continuous fluid collection and sensor device

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7066884B2 (en) 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
US8870810B2 (en) 1998-12-18 2014-10-28 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US7432069B2 (en) 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
US9572527B2 (en) 2007-04-27 2017-02-21 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery
US10390701B2 (en) 2016-11-17 2019-08-27 Samsung Electronics Co., Ltd. Apparatus and method for estimating biometric information

Also Published As

Publication number Publication date
JP2003527613A (en) 2003-09-16
CA2374751C (en) 2009-10-13
AU4580901A (en) 2001-10-03
AU781149B2 (en) 2005-05-05
WO2001070330A2 (en) 2001-09-27
EP1225831A2 (en) 2002-07-31
JP2012068263A (en) 2012-04-05
CA2374751A1 (en) 2001-09-27

Similar Documents

Publication Publication Date Title
WO2001070330A3 (en) Non-invasive body fluid sampling and analysis
WO2003008933A3 (en) Test strip for a lateral flow assay
RU2005112999A (en) EXECUTIVE SYSTEM FOR THE DEVICE FOR THE REMOVAL OF BIOLOGICAL LIQUID AND THE RELATED METHODS
WO2002100254A3 (en) Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
WO2006091426A3 (en) Methods and apparatus for extracting and analyzing a bodily fluid
WO1998024366A3 (en) Method and apparatus for obtaining blood for diagnostic tests
WO2004063713A3 (en) Non-invasive determination of direction and rate of change of an analyte
WO2003087775A3 (en) Monitoring blood substances using self-sampled tears
BR9912333A (en) System to continuously monitor a characteristic of a biological fluid extracted from an organism and a process to extract a biological fluid from a biological membrane of an organism and continuously monitor a characteristic of it.
WO2003095974A3 (en) Collection assembly
GB2322699A (en) Methods and devices for determination of an analyte in body fluid
EP1579814A3 (en) Methods and apparatus for sampling and analyzing body fluid
DE602004009736D1 (en) DEVICE FOR REMOVING BODY FLUIDS AND FOR ANALYTY MONITORING
WO2005085796A3 (en) System and method for integrating fluids and reagents in self-contained cartridges containing sensor elements
ATE371497T1 (en) SAMPLE COLLECTOR AND TEST APPARATUS
ATE286675T1 (en) DEVICE FOR SAMPLING INTERSTITIAL FLUID FOR DIAGNOSTIC TESTS
WO2005008216A3 (en) Sanitary fluid collection, application and storage device and methods of use of same
EP1411352A4 (en) Analyzing apparatus, piercing element integrally installed body for temperature measuring device with analyzing apparatus, and body fluid sampling apparatus
WO2002084266A3 (en) Biological measurement system
WO2001073395A3 (en) Method of preventing short sampling of a capillary or wicking fill device
RU2005104830A (en) PHYSIOLOGICAL LIQUID TAKE-UP SYSTEMS AND CONTROL CONTAINED IN ANALYT
EP0923905A3 (en) Liquid sample assay device
CA2448905A1 (en) Blood sampling apparatus and method
EP2347709A3 (en) Body fluid analyzer
WO2002057787A3 (en) Detection of survivin in the biological fluids of cancer patients

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 45809/01

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2001918770

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2374751

Country of ref document: CA

Ref country code: CA

Ref document number: 2374751

Kind code of ref document: A

Format of ref document f/p: F

Ref country code: JP

Ref document number: 2001 568521

Kind code of ref document: A

Format of ref document f/p: F

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 09979096

Country of ref document: US

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWP Wipo information: published in national office

Ref document number: 2001918770

Country of ref document: EP