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WO2001069222A3 - Implantable analyte sensor - Google Patents

Implantable analyte sensor Download PDF

Info

Publication number
WO2001069222A3
WO2001069222A3 PCT/EP2001/003026 EP0103026W WO0169222A3 WO 2001069222 A3 WO2001069222 A3 WO 2001069222A3 EP 0103026 W EP0103026 W EP 0103026W WO 0169222 A3 WO0169222 A3 WO 0169222A3
Authority
WO
WIPO (PCT)
Prior art keywords
analyte sensor
implantable analyte
electrodes
membrane
substrate
Prior art date
Application number
PCT/EP2001/003026
Other languages
French (fr)
Other versions
WO2001069222A2 (en
Inventor
Matthias Essenpreis
Original Assignee
Roche Diagnostics Gmbh
Matthias Essenpreis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh, Matthias Essenpreis filed Critical Roche Diagnostics Gmbh
Priority to CA002406814A priority Critical patent/CA2406814A1/en
Priority to AU2001260130A priority patent/AU2001260130A1/en
Priority to JP2001568055A priority patent/JP2003527599A/en
Priority to EP01933715A priority patent/EP1304952A2/en
Publication of WO2001069222A2 publication Critical patent/WO2001069222A2/en
Publication of WO2001069222A3 publication Critical patent/WO2001069222A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

An implantable analyte sensor includes a substrate, electrodes on the substrate, and a membrane on the electrodes. The membrane can comprise elemental silicon. The sensor can exhibit a signal drift of less than 20 % per day in vivo.
PCT/EP2001/003026 2000-03-17 2001-03-16 Implantable analyte sensor WO2001069222A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002406814A CA2406814A1 (en) 2000-03-17 2001-03-16 Implantable analyte sensor
AU2001260130A AU2001260130A1 (en) 2000-03-17 2001-03-16 Implantable analyte sensor
JP2001568055A JP2003527599A (en) 2000-03-17 2001-03-16 Embedded analyte sensor
EP01933715A EP1304952A2 (en) 2000-03-17 2001-03-16 Implantable analyte sensor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52830600A 2000-03-17 2000-03-17
US09/528,306 2000-03-17

Publications (2)

Publication Number Publication Date
WO2001069222A2 WO2001069222A2 (en) 2001-09-20
WO2001069222A3 true WO2001069222A3 (en) 2002-01-03

Family

ID=24105119

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/003026 WO2001069222A2 (en) 2000-03-17 2001-03-16 Implantable analyte sensor

Country Status (5)

Country Link
EP (1) EP1304952A2 (en)
JP (1) JP2003527599A (en)
AU (1) AU2001260130A1 (en)
CA (1) CA2406814A1 (en)
WO (1) WO2001069222A2 (en)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7471972B2 (en) 2001-07-27 2008-12-30 Dexcom, Inc. Sensor head for use with implantable devices
US7613491B2 (en) 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US8840553B2 (en) 1998-04-30 2014-09-23 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8843187B2 (en) 2003-08-22 2014-09-23 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8886273B2 (en) 2003-08-01 2014-11-11 Dexcom, Inc. Analyte sensor
US8882741B2 (en) 2004-02-26 2014-11-11 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US8915850B2 (en) 2005-11-01 2014-12-23 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8915849B2 (en) 2003-08-01 2014-12-23 Dexcom, Inc. Transcutaneous analyte sensor
US8920319B2 (en) 2005-11-01 2014-12-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8986209B2 (en) 2003-08-01 2015-03-24 Dexcom, Inc. Transcutaneous analyte sensor
US9011332B2 (en) 2001-01-02 2015-04-21 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9107623B2 (en) 2003-12-09 2015-08-18 Dexcom, Inc. Signal processing for continuous analyte sensor
US9220449B2 (en) 2005-03-10 2015-12-29 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9357951B2 (en) 2009-09-30 2016-06-07 Dexcom, Inc. Transcutaneous analyte sensor
US9414777B2 (en) 2004-07-13 2016-08-16 Dexcom, Inc. Transcutaneous analyte sensor
US9420968B2 (en) 2003-08-22 2016-08-23 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9446194B2 (en) 2009-03-27 2016-09-20 Dexcom, Inc. Methods and systems for promoting glucose management
US9451908B2 (en) 2006-10-04 2016-09-27 Dexcom, Inc. Analyte sensor
US9538946B2 (en) 2003-11-19 2017-01-10 Dexcom, Inc. Integrated receiver for continuous analyte sensor

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US6862465B2 (en) 1997-03-04 2005-03-01 Dexcom, Inc. Device and method for determining analyte levels
US9066695B2 (en) 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6702857B2 (en) 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US8260393B2 (en) 2003-07-25 2012-09-04 Dexcom, Inc. Systems and methods for replacing signal data artifacts in a glucose sensor data stream
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
AU2003303597A1 (en) 2002-12-31 2004-07-29 Therasense, Inc. Continuous glucose monitoring system and methods of use
EP1502957B1 (en) * 2003-07-11 2008-08-27 F. Hoffmann-La Roche Ag Castable diffusion membrane for enzyme-based sensor application
CA2473069C (en) 2003-07-11 2014-03-18 F. Hoffmann-La Roche Ag Castable diffusion membrane for enzyme-based sensor application
US9763609B2 (en) 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US20190357827A1 (en) 2003-08-01 2019-11-28 Dexcom, Inc. Analyte sensor
US20080119703A1 (en) 2006-10-04 2008-05-22 Mark Brister Analyte sensor
US6931327B2 (en) 2003-08-01 2005-08-16 Dexcom, Inc. System and methods for processing analyte sensor data
US8761856B2 (en) 2003-08-01 2014-06-24 Dexcom, Inc. System and methods for processing analyte sensor data
US20140121989A1 (en) 2003-08-22 2014-05-01 Dexcom, Inc. Systems and methods for processing analyte sensor data
WO2005032362A2 (en) * 2003-09-30 2005-04-14 Roche Diagnostics Gmbh Sensor with increaseed biocompatibility
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8808228B2 (en) 2004-02-26 2014-08-19 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US20070045902A1 (en) 2004-07-13 2007-03-01 Brauker James H Analyte sensor
JPWO2006090873A1 (en) * 2005-02-25 2008-07-24 有限会社アルティザイム・インターナショナル Fuel cell type enzyme sensor
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
US20200037874A1 (en) 2007-05-18 2020-02-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US8562558B2 (en) 2007-06-08 2013-10-22 Dexcom, Inc. Integrated medicament delivery device for use with continuous analyte sensor
US9452258B2 (en) 2007-10-09 2016-09-27 Dexcom, Inc. Integrated insulin delivery system with continuous glucose sensor
JP5212982B2 (en) * 2008-11-06 2013-06-19 独立行政法人物質・材料研究機構 Electrodes for electrochemical measuring devices and electrodes for biosensors
WO2012142502A2 (en) 2011-04-15 2012-10-18 Dexcom Inc. Advanced analyte sensor calibration and error detection
US11331022B2 (en) 2017-10-24 2022-05-17 Dexcom, Inc. Pre-connected analyte sensors
WO2019083939A1 (en) 2017-10-24 2019-05-02 Dexcom, Inc. Pre-connected analyte sensors
US11638543B2 (en) * 2019-07-16 2023-05-02 Dexcom, Inc. Analyte sensor electrode arrangements

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US5773270A (en) * 1991-03-12 1998-06-30 Chiron Diagnostics Corporation Three-layered membrane for use in an electrochemical sensor system
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WO1998038906A1 (en) * 1997-03-04 1998-09-11 Markwell Medical Institute, Inc. Device and method for determining analyte levels

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Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9326714B2 (en) 1998-04-30 2016-05-03 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8840553B2 (en) 1998-04-30 2014-09-23 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8880137B2 (en) 1998-04-30 2014-11-04 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9072477B2 (en) 1998-04-30 2015-07-07 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9014773B2 (en) 1998-04-30 2015-04-21 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9011331B2 (en) 1998-04-30 2015-04-21 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9498159B2 (en) 2001-01-02 2016-11-22 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9011332B2 (en) 2001-01-02 2015-04-21 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9328371B2 (en) 2001-07-27 2016-05-03 Dexcom, Inc. Sensor head for use with implantable devices
US7471972B2 (en) 2001-07-27 2008-12-30 Dexcom, Inc. Sensor head for use with implantable devices
US9282925B2 (en) 2002-02-12 2016-03-15 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9549693B2 (en) 2002-05-22 2017-01-24 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US7613491B2 (en) 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US8915849B2 (en) 2003-08-01 2014-12-23 Dexcom, Inc. Transcutaneous analyte sensor
US8986209B2 (en) 2003-08-01 2015-03-24 Dexcom, Inc. Transcutaneous analyte sensor
US8886273B2 (en) 2003-08-01 2014-11-11 Dexcom, Inc. Analyte sensor
US9427183B2 (en) 2003-08-22 2016-08-30 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9510782B2 (en) 2003-08-22 2016-12-06 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9149219B2 (en) 2003-08-22 2015-10-06 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US8843187B2 (en) 2003-08-22 2014-09-23 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9420968B2 (en) 2003-08-22 2016-08-23 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9585607B2 (en) 2003-08-22 2017-03-07 Dexcom, Inc. Systems and methods for replacing signal artifacts in a glucose sensor data stream
US9538946B2 (en) 2003-11-19 2017-01-10 Dexcom, Inc. Integrated receiver for continuous analyte sensor
US9364173B2 (en) 2003-12-09 2016-06-14 Dexcom, Inc. Signal processing for continuous analyte sensor
US9192328B2 (en) 2003-12-09 2015-11-24 Dexcom, Inc. Signal processing for continuous analyte sensor
US9498155B2 (en) 2003-12-09 2016-11-22 Dexcom, Inc. Signal processing for continuous analyte sensor
US9107623B2 (en) 2003-12-09 2015-08-18 Dexcom, Inc. Signal processing for continuous analyte sensor
US9351668B2 (en) 2003-12-09 2016-05-31 Dexcom, Inc. Signal processing for continuous analyte sensor
US9420965B2 (en) 2003-12-09 2016-08-23 Dexcom, Inc. Signal processing for continuous analyte sensor
US8920401B2 (en) 2004-02-26 2014-12-30 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US9155843B2 (en) 2004-02-26 2015-10-13 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US8926585B2 (en) 2004-02-26 2015-01-06 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US8882741B2 (en) 2004-02-26 2014-11-11 Dexcom, Inc. Integrated delivery device for continuous glucose sensor
US9414777B2 (en) 2004-07-13 2016-08-16 Dexcom, Inc. Transcutaneous analyte sensor
US9314196B2 (en) 2005-03-10 2016-04-19 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9220449B2 (en) 2005-03-10 2015-12-29 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9326716B2 (en) 2005-11-01 2016-05-03 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8920319B2 (en) 2005-11-01 2014-12-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8915850B2 (en) 2005-11-01 2014-12-23 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9451908B2 (en) 2006-10-04 2016-09-27 Dexcom, Inc. Analyte sensor
US9446194B2 (en) 2009-03-27 2016-09-20 Dexcom, Inc. Methods and systems for promoting glucose management
US9357951B2 (en) 2009-09-30 2016-06-07 Dexcom, Inc. Transcutaneous analyte sensor

Also Published As

Publication number Publication date
CA2406814A1 (en) 2001-09-20
JP2003527599A (en) 2003-09-16
EP1304952A2 (en) 2003-05-02
WO2001069222A2 (en) 2001-09-20
AU2001260130A1 (en) 2001-09-24

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