WO2000032144A1

WO2000032144A1 - Pressure-sensitive adhesive tape for pasting on skin and base material for use therein

Info

Publication number: WO2000032144A1
Application number: PCT/JP1999/006773
Authority: WO
Inventors: Hiromichi Fujisawa; Fumio Tokumura
Original assignee: Nichiban Co., Ltd.
Priority date: 1998-12-02
Filing date: 1999-12-02
Publication date: 2000-06-08
Also published as: DE69916424T2; DE69916424D1; EP1053728A4; US6262330B1; EP1053728A1; EP1053728B1

Abstract

A pressure-sensitive adhesive tape for pasting on skin comprising a base material having stretchability and moisture permeability and an adhesive layer formed on at least one surface thereof, characterized in that (a) its follow-up property expressed in terms of a stress at 15 % elongation is 4.2 times that of a stretchable film or less, (b) it has a moisture permeability of 500 g/m2 24 hr or more and (c) it has an adhesive strength to Bakelite of 1.5 N/15 mm or less: and a base material for use in a pressure-sensitive adhesive tape for pasting on skin comprising a microporous film which is formed from a resin composition containing a polyolefin resin and an inorganic filler and which has (1) a thickness of 40 to 200 νm, (2) an average pore diameter of 0.02 to 10 νm, (3) a gas permeability of 10 to 400 sec/100 cc, (4) a moisture permeability of 1,000 to 20,000 g/m2 24 hr and (5) a stress at 15 % elongation of 0.5 to 15 N/15 mm both in machine direction and transverse directions.

Description

Description Adhesive tape for sticking skin and its support

The present invention relates to a pressure-sensitive adhesive tape for skin application, and more particularly, to a pressure-sensitive adhesive tape for skin application that has stable adhesiveness when sweating or applied for a long time and has little pain, exfoliation, and skin irritation when exfoliated. Further, the present invention relates to a low-irritating pressure-sensitive adhesive tape for applying to the skin, which has excellent skin-following properties and moisture permeability, has stable adhesive strength, and has reduced pain at the time of peeling, exfoliation of keratin, and skin irritation. Further, the present invention relates to a support suitable for such a low-irritant pressure-sensitive adhesive tape for applying to skin. The pressure-sensitive adhesive tape for application to the skin of the present invention is particularly suitable as a medical pressure-sensitive adhesive tape for protecting a skin affected site or a surgical site, transdermal absorption of a drug, and the like. Background art

Conventionally, various kinds of adhesive tapes for affixing to the skin have been developed for protecting the affected skin and transdermal absorption of drugs. In general, an adhesive tape for application to the skin has a structure in which an adhesive layer containing a drug is formed on one surface of a flexible support as necessary.

Adhesive tapes for application to the skin include (1) good skin-following properties that can follow the shape and movement of the skin surface to be affixed, (2) no water retention due to perspiration, and excellent moisture permeability, (3) ) It is required that there be no pain or exfoliation of the stratum corneum at the time of exfoliation, (4) that the skin adherence be maintained for a long time, and (5) that there is no skin disorder such as rash, itch or erythema. However, since the adhesive tape for skin application is often applied to the skin surface for a long period of time, there has been a problem that side effects such as skin irritation always accompany.

Conventionally, various proposals have been made to reduce various problems such as skin irritation. For example, (1) by forming a crosslinked pressure-sensitive adhesive layer containing an acrylate polymer and a liquid component compatible with the polymer on a support, the exfoliation of keratinocytes during exfoliation is reduced. (Japanese Unexamined Patent Publication No. Hei 5 — 652224), and (2) a method of reducing skin damage and skin irritation by imparting moisture permeability to the support and the pressure-sensitive adhesive layer (Japanese Unexamined Patent Publication No. (Japanese Unexamined Patent Publication (Kokai) No. 2779225, Japanese Patent Application Laid-Open No. 7-1575742, Japanese Patent Application Laid-Open No. 7-275340), and Methods for reducing skin irritation and exfoliation of the stratum corneum by using a pressure-sensitive adhesive containing a substance (Japanese Patent Application Laid-Open Nos. 6-16541 and 7-206710) (4) A method for preventing the occurrence of irritation, rash, itching, erythema, etc. on the human body by reducing the amount of residual monomer in the adhesive (5 — 1310 22), (5) A method of imparting skin-following properties by using an elastic support (Japanese Patent Application Laid-Open No. 7-138152, Japanese Patent Application Laid-Open -1 1 7 268).

However, the occurrence of skin irritation due to the application of the adhesive tape for skin application involves various factors intricately intertwined, so improving a single factor or two factors is sufficient to solve the problem. Does not reach. In addition, for example, if measures are taken to reduce skin irritation, problems such as a decrease in tackiness and skin followability are likely to occur, and it has been difficult to properly balance various properties.

On the other hand, examples of the support used for the adhesive tape for skin application include, for example, Polyethylene film, ethylene-methyl methacrylate copolymer (EMMA) film, polyvinyl chloride film, polyurethane film, polyester elastomer film, polyvinyl alcohol film, polyolefin microporous film, polyurethane nonwoven fabric, polyester elastomer nonwoven fabric Are used.

Among these supports, films such as polyethylene film, EMMA film, and polychlorinated biel film do not themselves have moisture permeability, and are perforated by a punch to impart moisture permeability. However, the porosity due to perforation is at most a few percent, and the gap between the holes is large, and where there are no holes, there is no moisture permeability, so there is a problem that sufficient moisture permeability cannot be obtained. is there.

Polyurethane film, polyester elastomer film, polyvinyl alcohol film, polyurethane non-woven fabric, polyester elastomer non-woven fabric, etc. have the problem of being too soft in addition to being expensive. The adhesive tape for application to the skin, whose support is too soft, is difficult to handle because it will wrinkle when applied to the skin surface. Also, when the thickness of the polyurethane film or the polyvinyl alcohol film is increased, the moisture permeability is remarkably reduced even at about 40 m, and almost no film shows the moisture permeability at 60 zm or more.

Polyolefin-based microporous films are known to have excellent moisture permeability of more than 2,500 g / m2,24 h, have skin-tracking properties, and are relatively inexpensive. is there. However, many conventional polyolefin-based porous films have air permeability values of 500 cc or more and have a small thickness, making them suitable for applications such as disposable diapers and sanitary products. However, as a support for adhesive tape for skin application Was not satisfactory. According to the study results of the present inventors, when an adhesive layer is formed on the surface of a polyolefin-based microporous film having a permeability value of 500 sec / 100 cc or more, the moisture permeability is remarkably increased. It was found that the pressure-sensitive adhesive tape having a high moisture permeability was not obtained. When applied to the skin, the adhesive tape for skin application is resistant to stuffiness, has a small amount of exfoliation, and shows stable adhesive strength. Preferably, it has a moisture permeability of 700 g Zm 2 ′ 24 h or more. However, when the microporous film is used as a support, an adhesive tape having a sufficient moisture permeability cannot be obtained. Also, if the thickness of the polyolefin-based microporous film is too thin, there is a problem that the support is too soft. Increasing this thickness further reduces the moisture permeability of the adhesive tape. Disclosure of the invention

The object of the present invention is that all of the properties of skin followability, moisture permeability, and skin adhesion are within an appropriate range, and these properties are highly balanced. An object of the present invention is to provide a pressure-sensitive adhesive tape for application to the skin, which has a stable property and significantly reduces pain at the time of peeling, exfoliation of the skin, and skin irritation.

In addition, the object of the present invention is that all of the properties of skin following, moisture permeability, and skin adhesiveness are within an appropriate range, and these properties are highly balanced. An object of the present invention is to provide a pressure-sensitive adhesive tape for sticking skin, which has stable adhesiveness and significantly reduces pain at the time of peeling, keratin peeling, and skin irritation.

Another object of the present invention is to provide a skin patch having such excellent properties. An object of the present invention is to provide a microporous film support suitable as a support for a pressure-sensitive adhesive tape.

The inventors of the present invention have conducted intensive studies to overcome the problems of the prior art, and as a result, have found that an acrylic adhesive, a rubber adhesive, Tape with a pressure-sensitive adhesive layer consisting of a pressure-sensitive adhesive, silicone-based pressure-sensitive adhesive, vinyl ether-based pressure-sensitive adhesive, etc. It was found that it had skin-following properties, moisture permeability, and skin stickiness, and was suitable as an adhesive tape for sticking to the skin. This pressure-sensitive adhesive tape for skin application has stable adhesiveness when sweating or when applied for a long period of time, and has little pain upon exfoliation, exfoliation of keratin, and skin irritation.

Further, the present inventors are a microporous film formed from a resin composition containing a polyolefin-based resin and an inorganic filler, having a thickness of 40 to 200 m and an average pore diameter of 0.02. ~: LO m, air permeability is 10 to 400 sec Z l 100 cc, moisture permeability is 1, 000 to 200, 000 g / m2 * 24 h, and machine direction and A microporous film having the selected characteristics of 0.5 to 15 N / 15 mm in stress at the time of 15% elongation in the width direction is suitable as an adhesive tape base material for application to the skin Was found. By using this microporous film as a support, a pressure-sensitive adhesive tape for application to the skin having the above-mentioned various properties can be obtained. The present invention has been completed based on these findings.

According to the present invention, there is provided a pressure-sensitive adhesive tape for skin application, wherein a pressure-sensitive adhesive layer is formed on at least one surface of a stretchable support having moisture permeability.

(a) The stretchability of stretchable film at 15% elongation 4. Less than 2 times,

(b) moisture permeability of 500 g m2 · 24 h or more, and

(c) Adhesive strength per client is 1.5 NZ l 5 mm or less

A pressure-sensitive adhesive tape for sticking to skin is provided.

According to the present invention, there is also provided a microporous film formed from a resin composition containing a polyolefin resin and an inorganic filler,

(1) Thickness 40 ~ 200 / m,

(2) The average pore size is 0.02 ~: L 0 m,

(3) Air permeability is 10 ~ 40 0 se c Z l 0 0 c c,

(4) Moisture permeability is 1, 000 to 200, 000 gZm2 '24 h, and

(5) The stress at the time of 15% extension in the machine direction and the width direction is 0.5 to 15 N / 15 mm.

The present invention provides a skin adhesive pressure-sensitive adhesive tape support comprising a microporous film. BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 is an explanatory diagram showing a method for measuring the stretchability of an adhesive tape according to an elastic film.

FIG. 2 is an explanatory diagram showing a method for measuring the amount of adhesive displacement.

FIG. 3 is an explanatory diagram showing a method for measuring the skin following property of an adhesive tape. BEST MODE FOR CARRYING OUT THE INVENTION

(1) Support

Examples of the support used for the pressure-sensitive adhesive tape for application to the skin of the present invention include a film or a nonwoven fabric having high moisture permeability and good elasticity. As an objective measure of the elasticity of the support, the stress at 15% elongation Can be used. The stress at the time of 15% elongation in the machine direction (MD) and the width direction (TD) of the support used in the present invention is usually 15 NZl 5 mm or less, preferably 12 NZmm or less, more preferably. Or 1 ON / 15 mm or less. The lower limit of the stress at 15% elongation of the support is usually 0.5 NZ15 mm, preferably 0.7 NZ15 mm, more preferably 1 N / 15 mm.

When the stress at the time of 15% elongation of the support is within this range, an adhesive tape which can easily follow the movement of the skin surface to be applied can be obtained. Here, the stress at the time of 15% elongation of the support is 15 mm in width in an atmosphere of 23 ± 2 ° 〇 in temperature, relative humidity 65 5% in accordance with JISK-7115, and 5% in relative humidity. This value is measured as the stress when a 150 mm long sample is stretched by 15% using an Instron type tensile tester at a grip interval of 100 mm and a speed of 30 OmmZmin.

The moisture permeability of the support of the present invention can be objectively evaluated based on the moisture permeability measured under the JISZ-0208 B condition (temperature: 40 ° C., relative humidity: 90%). Moisture permeability of the support used in the present invention is ^{usually, 5 0 0 g / m 2} - 24 h excess, preferably YOO gZm ² '24 h or more on, and more preferably 1, 0 0 0 g / m2 , 2 4 h or more. When the moisture permeability of the support is within the above range, moisture generated by perspiration at the time of application can be effectively evaporated to obtain an adhesive tape which is less likely to cause skin irritation. In many cases, good results can be obtained when the moisture permeability of the support is in the range of 1,000 to 200,000 gZm2 '24 h.

Specific examples of such a stretchable support having moisture permeability include, for example, a polyurethane film, a polyester elastomer film, a polyolefin-based breathable film, and a polyvinyl alcohol film. Nonwoven fabric, polyurethane elastomer nonwoven fabric, polyester elastomer nonwoven fabric, thermoplastic polyolefin nonwoven fabric, and the like. The thickness of the support is usually from 40 to 200 m, preferably from 45 to: L50 / zm, more preferably from 50 to 100 m. If the thickness is too thin, it will be too soft and the resulting adhesive tape for skin application will be difficult to handle. If the thickness is too large, the flexibility is impaired, and the skin followability of the resulting adhesive tape for skin application is reduced.

Among the moisture-permeable stretchable supports, a polyolefin-based breathable film is preferred. More specifically, in the present invention, a microporous film formed from a resin composition containing a polyolefin-based resin and an inorganic filler is used as a support of a low-irritant pressure-sensitive adhesive tape for skin application. Is preferred. In order to produce a microporous film, for example, there is a method in which an unstretched film is produced using the resin composition, and then the film is stretched in a uniaxial or biaxial direction to form a stretched film.

Examples of polyolefin resins include low-density polyethylene, medium-density polyethylene, high-density polyethylene, linear low-density polyethylene, ultra-low-density polyethylene, polypropylene, ethylene-propylene copolymer, and ethylene-vinyl acetate copolymer. Coalescence, ionomer resin, and the like. Polyolefin-based resins include ethylene-polyolefin copolymers. Examples of α-olefins include 1-butene, 3-methyl-1-butene, 4-methyl-1-pentene, 1-hexene, 1-octene, 1-decene, and the like.

These polyolefin-based resins may be those obtained using a usual catalyst of Nadler-Natta, or may be a meta-mouth catalyst or a confined catalyst. It may be obtained using a single-site catalyst such as a geometric catalyst. The density of the polyolefin resin is usually about 0.89 to 0.97 g ZcmS, and the melt index (Ml) is usually 0 :! About 50 g / 10 min. These polyolefin resins can be used alone or in combination of two or more.

Examples of the inorganic filler include calcium carbonate, calcium oxide, aluminum oxide (alumina), titanium oxide, silica, clay, silver, and aluminum sulfate. These inorganic fillers can be used alone or in combination of two or more. The form of the inorganic filler is arbitrary, but is preferably in the form of spherical, granular, amorphous, or the like. The average particle size of the inorganic filler is usually from 0.07 to 15 m, preferably from 0 :! It is about 9 m. When the average particle size is within this range, the stretchability is good, and the average pore size, air permeability, moisture permeability, and the like can be easily adjusted to desired ranges.

The mixing ratio of the inorganic filler is usually about 50 to 250 parts by weight, preferably about 80 to 200 parts by weight, based on 100 parts by weight of the polyolefin resin. When the blending ratio of the inorganic filler is within this range, various properties of the obtained microporous film can be adjusted to a desired range.

Additives such as dispersants, heat stabilizers, ultraviolet absorbers, lubricants, pigments, and antistatic agents should be added to the resin composition containing the polyolefin resin and the inorganic filler, if necessary. Can be. In particular, high carbon numbers of 10 to 22 such as oleic acid, lauric acid, myristic acid, palmitic acid, stearic acid, linoleic acid, linolenic acid, and ricinoleic acid. Dispersants such as fatty acid esters of higher fatty acids having 10 to 22 carbon atoms and aliphatic alcohols having 1 to 12 carbon atoms (for example, refined castor oil) improve the stretchability, improve air permeability, This is preferable because it can increase the soft feeling and improve the texture. The dispersants can be used alone or in combination of two or more. The dispersant is added in an amount of usually 0.5 to 25 parts by weight, preferably 1 to 20 parts by weight, based on 100 parts by weight of the polyolefin resin.

In order to prepare a microporous film using the above resin composition, the resin composition is melt-molded into an unstretched film (sheet) by a T-dye method and an inflation method, and then is uniaxially or The film is stretched biaxially to form a stretched film. Simultaneous biaxial stretching may be performed. The stretching method is not particularly limited. Examples of the uniaxial stretching include flat mouth stretching, oven stretching, and tubular stretching. Biaxial stretching includes a flattened template. Evening stretching, tubular inflation stretching, mandrel stretching, etc.

The stretching ratio is at least uniaxial, usually about 1.2 to 6 times, preferably about 1.5 to 5 times, and more preferably about 2 to 3 times. After stretching, the film may be heat-treated under tension and heat-set to increase dimensional accuracy. Other stretching conditions such as stretching temperature and heat treatment conditions can be appropriately selected according to ordinary stretching conditions for polyolefin-based resins. By stretching, the interface between the polyolefin-based resin and the inorganic filler is separated, and a microporous structure is formed in the stretched film.

In the present invention, the type of polyolefin resin, the type and blending ratio of the filler, the type and amount of the additive such as the dispersant, and the stretching conditions such as the stretching ratio By appropriately controlling the conditions and the like, a microporous film having the following characteristics is produced.

(1) The thickness is 40 ~ 200 / m,

(2) Average pore size is 0.02 ~ 10m,

(3) Air permeability is 10 ~ 4 0 0 se c 1 0 0 c c,

(4) Moisture permeability of 1, 0 0 to 2 0, 0 0 g / m ² · 24 h, and

The thickness of the microporous film of the present invention is from 40 to 200 °, preferably from 45 to: L50 m, and more preferably from 50 to LOOzm. If the thickness is too thin, it will be too soft and the resulting adhesive tape for skin application will be difficult to handle. If the thickness is too large, the flexibility is impaired, and the skin following property of the resulting adhesive tape for skin application is reduced.

The average pore size of the microporous film of the present invention is from 0.02 to 10 °, preferably from 0.05 to 6 / m, and more preferably from 0 :! to 5 m. The average pore diameter can be obtained by taking a photograph of the microporous film with a scanning electron microscope, observing this photograph, measuring the major diameter of each pore, and calculating the average value.

The pore size is usually distributed in the range of 0.01 to 20 m, but in most cases it is less than 10 m, which results in a microporosity with many fine pores formed. It becomes a film. If the average pore size is too small, the air permeability and the moisture permeability decrease. If the average pore size is too large, the flexibility will decrease.

The air permeability of the microporous film of the present invention is 10 to 400 sec Z100 cc, preferably 10 to 300 sec Z100 cc. More preferably, 30 to 280 sec Z100cc, particularly preferably 50 to 270sec 100c. It is. The air permeability is J

It can be measured by the air permeability test method of 1 S P—8 11 17 (temperature 23 ° C, relative humidity 65%). This air permeability is constant area (64

This is the time required for 100 cc of air at a constant pressure to pass through a 5 mm ² ) film surface. The smaller the time, the better the air permeability. If the air permeability of the microporous film is too large, even if the moisture permeability is high, only a pressure-sensitive adhesive tape with extremely low moisture permeability can be obtained by applying an adhesive on the surface as a support for the adhesive tape. . If the air permeability is too low, the flexibility tends to be impaired, and the adhesive easily penetrates the pores. When the air permeability is within the above range, the moisture permeability of the pressure-sensitive adhesive tape can be set to 700 g / m2 to 24 hours or more, which is desirable for sticking to the skin.

The moisture permeability of the microporous film of the present invention is 1,000 to 20,000 gZm ² '24 h, preferably 2,500 to 15,500 g / ΙΏ2 · 24. h, more preferably 3, 000 ~ 10, OOO gZm? '

24 h. If the moisture permeability of the microporous film is too small, the moisture permeability of the adhesive tape will decrease. If this moisture permeability is too large, it becomes brittle. The stress (also referred to as 15% tensile stress) at the time of 15% elongation in the machine direction (MD) and the width direction (TD) of the microporous film of the present invention is 0.5 to 15 NZ 15 mm. , Preferably 0.7 to 12 NZ 15 mm, more preferably 1 to 10 NZ 15 mm. The flexibility of a microporous film can be objectively evaluated by measuring the stress at 15% elongation. When the stress at the time of 15% elongation of the microporous film is within the above range, an adhesive tape which can easily follow the movement of the skin surface to be stuck can be obtained. If this stress is too small, it will be too soft, It becomes unsuitable as a support for the pressure-sensitive adhesive tape for skin application. If this stress is too high, the flexibility will decrease.

(2) Adhesive

The pressure-sensitive adhesive used for the pressure-sensitive adhesive tape for skin of the present invention is preferably one that hardly exfoliates keratinocytes from the skin surface at the time of peeling and hardly damages the skin surface. As an adhesive having such adhesive properties, an adhesive strength against a single client when an adhesive tape is used can be used as an index.

The adhesive used in the present invention has an adhesive strength to bakelite of 1.5 NZ15 mm or less, preferably 1.4 N / 15 mm or less. The lower limit of the adhesive strength per client is usually 0.6 N / 15 mm, preferably 0.8 N / 15 mm. Here, the adhesive strength per client is the adhesive strength of an adhesive tape having a width of 15 mm with respect to a bare client panel in accordance with the 180-degree peeling method of JISZ-0 237. Value.

Further, the pressure-sensitive adhesive used in the present invention is preferably excellent in moisture permeability. When a pressure-sensitive adhesive layer is formed on the support, the pressure-sensitive adhesive has a moisture permeability of 500 g / m2-24 h or more. Preferably, the adhesive tape has a value of at least 700 gZm2'24 h, more preferably at least 1,000 gZm2'24 h. The upper limit of the moisture permeability of the adhesive tape is usually about 5,000 g nom2 · 24 h. If the moisture permeability of the adhesive tape is too small, it will cause moisture to accumulate due to sweating, exfoliation of the stratum corneum during exfoliation, skin rashes such as rash, itchiness and erythema. The upper limit of the moisture permeability of the adhesive tape is limited by the air permeability and moisture permeability of the support, the type of the adhesive, and the like.

In addition, the amount of adhesive displacement (mmZl SXSO mm? '2 N-30 min) is 0.15 from the viewpoint of reducing skin irritation. A pressure-sensitive adhesive having a range of about 1.20 mm is preferable. That is, as with the support, a pressure-sensitive adhesive that does not hinder the movement of the skin surface to be applied is preferable for obtaining a hypoallergenic adhesive tape for application to the skin. In the case of an adhesive tape, the adhesive properties of such an adhesive are evaluated by the amount of displacement of the adhesive with respect to a primer-treated, non-stretchable hard film surface (for example, a polyethylene terephthalate (PET) film with a primer). be able to. The shift amount of the pressure-sensitive adhesive used in the present invention is preferably 0.17 to 1.0 mm, more preferably 0.20 to 0.50 mm. If the amount of adhesive displacement of the adhesive tape is too small, skin irritation increases. If the shift amount of the adhesive is too large, the adhesive tends to remain on the skin surface.

Examples of the pressure-sensitive adhesive used for the pressure-sensitive adhesive tape for application to the skin of the present invention include an acrylic pressure-sensitive adhesive, a rubber-based pressure-sensitive adhesive, a silicone-based pressure-sensitive adhesive, and a vinyl ether-based pressure-sensitive adhesive. Among these adhesives, from the viewpoint of initial tack or skin irritation, a monomer or monomer mixture containing an alkyl (meth) acrylate as a main component monomer is (co) polymerized. The obtained acrylic pressure-sensitive adhesive is preferred. From the viewpoints of stable skin adhesion, high moisture permeability, reduction of exfoliation of keratin, and reduction of skin pain at the time of exfoliation, (meth) alkoxypolyalkylene glycol acrylate (meth) acrylate, hydroxyl group or calcium An acryl-based pressure-sensitive adhesive containing an acryl-based copolymer obtained in combination with a poxyl group-containing monomer as a pressure-sensitive adhesive component is particularly preferred.

More specifically, preferred acrylic pressure-sensitive adhesives include (1) 50 to 97.5% by weight, preferably 70 to 90% by weight of alkyl (meth) acrylate having an alkyl group having 4 to 12 carbon atoms. 9 5% by weight, (2) (medium) Alkoxy polyalkylene glycol ester 2- 49.5% by weight, preferably 4 to 29% by weight, and (3) a copolymer containing 0.5 to 15% by weight, preferably 1 to 10% by weight of a monomer having a hydroxyl group or a carboxyl group. be able to. The copolymer may further be obtained by copolymerizing another copolymerizable vinyl monomer in the range of about 0 to 30% by weight.

Examples of (meth) acrylic acid alkyl esters having an alkyl group having 4 to 12 carbon atoms include n-butyl acrylate, isobutyl acrylate, t-butyl acrylate, and 2-ethyl acrylate. Xyl, n-octyl acrylate, isooctyl acrylate, isononyl acrylate, decyl acrylate, dodecyl acrylate, n-butyl methacrylate, isobutyl methacrylate, t-butyl methacrylate And 2-ethylhexyl methacrylate, n-octyl methacrylate, isooctyl methacrylate, isononyl methacrylate, decyl methacrylate, dodecyl methacrylate and the like. Of these, 2-ethylhexyl acrylate, n-octyl acrylate, isooctyl acrylate, and isononyl acrylate are preferred. These alkyl (meth) acrylates can be used alone or in combination of two or more.

The (meth) alkoxypolyalkylene acrylate ester is represented by the following formula (1)

R, R ₂

¾C = C-C-0-(CH ₂ -CH-0) „-R ₃ (1)

II

0

(In the formula, R i and R ₂ are each independently a hydrogen atom or a methyl group, R ₃ is an alkyl group having 1 to 20 carbon atoms, and n is an integer of 2 to 12). It is a (meth) acrylic acid ester represented by

Specific examples of the monomer represented by the formula (1) include, for example, methoxydiethylene glycol acrylate (R i = H, R 2 = H, R 3 = CH ₃ , n = 2), Methoxydiethylene glycol acrylate (R i = CH ₃ , R2 = H, R ₃ = CH ₃ , n = 2), methoxy dipropylene glycol acrylate (R 1 = H, R 2 = CH 3, R ₃ = CH 3, n = 2), methacrylic dipropylene glycol (R 1 = CH ₃ , R 2 = CH ₃ , R3 = CH ₃ , n = 2), Lil San'e butoxy diethylene glycol (R iH, R2 = H, R 3 = C 2H5, n = 2), main Yuku acrylic acid ethoxy diethylene glycol _{(R i = CH 3, R} 2 = H, R 3 = C 2 H 5, n = 2), Accession acrylic acid ethoxyethyl dipropylene grayed Li co one Le _{(R i = H, R 2} = CH 3, R 3 = C 2H5, n = 2), main Yuku Lil Sane Tokishiji Propylene dalycol (R i = CH ₃ , R 2 = CH 3, R 3 = C 2H 5 , n = 2), methacrylic acid methacrylate (R iH, R2 = H, R 3 = CH ₃ n = 3), methacrylic acid methacrylate (R i = CH ₃ , _{R2 = H, R 3 = CH} 3, n = 3), Accession Lil Sanme butoxy preparative polypropylene glycol (R 1 = H, R 2 = CH 3, R 3 = CH 3> n = 3), main evening click Lil Sanme Tokishito polypropylene da recall _{(R! = CH 3, R} 2 = CH 3, R 3 = C 2H 5¾ n = 3), Accession Lil Sanme butoxy polyethylene glycol (R i = H, R 2 = H > R 3 = CH ₃ , n = 4 to: 10), methoxypolyethylene glycol methacrylate (Ri-CH ^ R 2 = H, R 3 = CH ₃ n = 4 to 10), methacrylic acid butoxy polypropylene glycol (R 1 = H, R 2 = C H3 R3 = CH 3, n = 4~:. LO), Metaku Lil Sanme Bok carboxymethyl polypropylene glycol _{(R 1 = CH 3, R} 2 = CH 3 , R 3 = CH 3, n = 4 ~: L 0) I can do it. Examples of the monomer having a hydroxyl group or a hydroxyl group include a hydroxyalkyl (meth) acrylate and a carboxyalkyl (meth) acrylate. Specific examples of these monomers include, for example, 2-acryloxylate, 2-carboxyethyl acrylate, 2-hydroxypropyl acrylate, 2-hydroxypropyl acrylate, and acryloxyl. Acid 3—Hydroxypropyl, Acrylate 3—Carboxypropyl, Acrylate 4—Hydroxybutyl, Acrylate 4—Lepoxybutyl, Methacrylic acid 2—Hydroxyshetyl, 2-Methoxycarboxylate, Methacrylic acid 2—Hydroxypropyl, Methacrylic acid 2—Hydroxypropyl, Methacrylic acid 3—Hydroxypropyl, Methacrylic acid 3—Carpoxypropyl, Methacrylic acid 4-hydroxybutyl, Meta 4-carboxybutyl acrylate and the like.

The hydroxyl group-containing monomer has the formula (2)

R ₄ R ₅

H ₂ C = C— C— O— (C — CH-0) _m — H (2)

II

0

(In the formula, R 4 and R 5 are each independently a hydrogen atom or a methyl group, and m is an integer from 2 to L 2.)

And (meth) acrylic acid esters having a hydroxyl group such as polyethylene glycol (meth) acrylate and polypropylene glycol (meth) acrylate represented by

Further, as the carboxyl group-containing monomer, the formula (3)

H ₂ C = C— C-1 0— X— COOH (3)

II

0 (In the formula, R ₆ is a hydrogen atom or a methyl group, X is a divalent organic group having 2 or more carbon atoms, and includes a hetero atom such as an oxygen atom, a nitrogen atom, and a sulfur atom. Is also good.)

And a (meth) acrylic acid ester containing a lipoxyl group represented by the following formula:

In the formula (3), the number of carbon atoms of X is preferably about 2 to 50, and more preferably about 2 to 30. Heteroatoms are often oxygen atoms. Specific examples of X include, for example, a linear or branched alkylene group having 2 or more carbon atoms, one R ₇ —〇CO—R— (where R ₇ and R 8 are alkylene groups) , —R g— OCO—R ₁₀ —OCO—R π— (where R ₉ , Ri ₀ , and R 11 are alkylene groups). Specific examples of the (meth) acrylic acid ester having a carboxyl group represented by the formula (3) include, for example, 2-carboxyethyl acrylate, 2-acloiroxixethyl succinic acid, Lylic acid ω-force lipoxypolyforce prolactone.

Other copolymerizable vinyl monomers include, for example, methyl acrylate, ethyl acrylate, isopropyl acrylate, methyl methacrylate, ethyl methacrylate, isopropyl methacrylate, tridecyl acrylate, tridecyl methacrylate, etc. (Meth) acrylic acid alkyl esters of acrylonitrile; methacrylic acid, maleic acid, maleic anhydride, maleic anhydride, itaconic acid, and other monomers containing lipoxyl groups; acrylamide, methacrylamide, 、 -methylolacrylamide (Meth) acrylamide and derivatives thereof: epoxy-containing monomers such as daricidyl acrylate and glycidyl methacrylate; vinyl esters such as vinyl acetate; acrylonitrile and methacryloyl -Unsaturated nitriles such as nitrile; bier aromatic compounds such as styrene;

Various general-purpose additives can be added to the pressure-sensitive adhesive used in the present invention, if desired. A transdermally absorbable drug can be added to the adhesive if desired. Transdermally absorbable drugs include, for example, angina pectoris, corticosteroids, analgesics and anti-inflammatory drugs, hypnotic analgesics, anti-inflammatory drugs, anti-allergic drugs, antihistamines, coronary vasodilators, antibacterial drugs, moisturizer , Vitamins, antitussives, anesthetics, antitumor agents, fragrances, etc. These drugs are added in effective amounts as needed.

(3) Adhesive tape for application to skin

The skin pressure-sensitive adhesive tape of the present invention can be produced by applying a pressure-sensitive adhesive on at least one surface of a stretchable support having moisture permeability according to a conventional method. The adhesive may be coated on the separation and transferred onto the support. To apply the pressure-sensitive adhesive, apply a solution in which the base polymer and, if necessary, additive components are uniformly dissolved or dispersed in an organic solvent, onto a support or a separator, and then dry. Good. The thickness of the pressure-sensitive adhesive layer is usually 20 to 60 m, preferably 30 to 50 m.

The pressure-sensitive adhesive tape for application to the skin of the present invention has the following properties.

(a) The stretch film following property is 4.2 times or less, preferably 4.0 times or less, more preferably 3.8 times or less of the stretch film stress at 15% elongation, and in many cases, 2 4 to 4.2 times the range;

(b) water vapor permeability 5 0 0 g Zm2 · 2 4 h or more, preferably 7 0 0~ 5, 0 0 0 g / m 2 · 2 4 h, more preferably 7 5 0~ 3, 0 0 0 g No m2 - 2 4 h, particularly preferably 8 0 0~ 2, 0 0 O g / m 2 '2 4 h;

(c) Adhesive strength to bakelite is 1.5 NZ 15 mm or less, preferably 0.6 to: 1.5 N / 15 mm or less, more preferably 0.8 to 1.4 N / 15 mm .

To measure the followability of the adhesive tape to the stretchable film, attach the adhesive tape sample to the stretchable film and use an installation-type tensile tester at a speed of 10 O mmZmin. The stress of the sample of the pressure-sensitive adhesive tape when 15% is stretched is measured. The measured value of this stress is the followability of the adhesive tape to the stretchable film. Divide the measured value of this stress by the stress at the time of 15% elongation of the stretchable film to calculate the magnification. This magnification must be less than 4.2 times. In Examples and Comparative Examples, a polyurethane film (thickness 2711) having a stress of 0.84 NZ15 mm when stretched by 15% was used as the stretchable film. This is because the polyurethane film resembles the condition of human skin. With this value (magnification), the skin following property of the adhesive tape can be objectively evaluated. The skin followability of the pressure-sensitive adhesive tape of the present invention can be measured by actually sticking it to the skin of the human body. However, since the skin of the human body has individual differences, such followability of the stretchable film is objective. It is an indicator. The stress of the adhesive tape measured by the above-mentioned measuring method is usually in the range of 2.5 to 3.5 N / 15 mm (magnification = 3.0 to 4.2 times).

In addition, the adhesive tape of the present invention,

(d) The deviation amount of the adhesive (mmZ 12 X 20 mm ² · 2 N · 30 min) is preferably 0.15 to 1.20 mm, more preferably 0.17 to 1.O mm, particularly preferably 0.20 to 0.50 mm

From the viewpoint of suppressing skin irritation and adhesive residue on the skin surface Desirable.

Since the pressure-sensitive adhesive tape for skin application of the present invention has such various properties, it has good skin followability, little water retention at the time of application, and low adhesiveness at the time of sweating or long-time application. It is good and has the characteristics of less pain at the time of exfoliation, exfoliation of keratin and less skin irritation. Therefore, the pressure-sensitive adhesive tape for skin application of the present invention can be used for the purpose of protecting the skin protection such as protection of the affected part of the skin and the affected part after surgery, and percutaneous absorption of a drug. Example

Hereinafter, the present invention will be described more specifically with reference to Examples and Comparative Examples. In the following Examples and Comparative Examples, parts and% are based on weight unless otherwise specified.

The methods for measuring the properties, properties, and performances of the support and the pressure-sensitive adhesive tape are as follows.

1. Support

(1) Average pore size

The average value (unit: m) of the major axis of the hole measured by using a scanning electron microscope was calculated and defined as the average pore diameter (n = 10). There are various shapes of holes such as ellipse, diamond, rectangle, and polygon. The long diameter means the longest diameter or the length of the diagonal line. The measurement temperature is room temperature (18 to 27 ° C).

(2) Air permeability

Measured the time (unit: sec / 100 cc) for passing 100 cc of air at a constant pressure through a 645 mm 2 film surface in accordance with the air permeability test method of JISP — 8 11 17 (Η = 3). Measurement atmosphere is temperature 23 ± 2 ° C, relative humidity 65 ± 5%.

(3) Moisture permeability

In accordance with the JISZ-020 B condition (temperature 40, relative humidity 90%), adjust one side of the 36 cm2 film surface to a temperature of 40 ° C and a relative humidity of 90%, and adjust to the other side. Approximately 16 g of a moisture absorbent (calcium chloride) was used to absorb the water that passed through the film, and the change in the weight of calcium chloride was converted into 1 m2, 24 hours, and the moisture permeability was determined (n =

3).

(4) Stress at 15% elongation

In accordance with JISK-7 11-15, the stress load when the sample is extended by 15% with a tensile tester (sample width 15 mm, gripping interval 100 mm, stretching speed 300 mm / min ) Was measured. The measurement atmosphere was a temperature of 23 ± 2 ° C and a relative humidity of 65 ± 5%.

2. Characteristics of adhesive tape

(1) Followability of stretchable film

As shown in Fig. 1, a polyurethane film 1 (thickness: 27 / m) with a stress of 0.84 NZl 5 mm at 15% elongation is cut into a size of 18 mm x 150 mm and installed. The chucks 3 and 4 of the TRON type tensile tester were fixed so that the spacing between them was 100 mm. Adhesive tape 2 cut to 15 mm x 98 mm is pasted on polyurethane film 1, and the stress of adhesive tape 2 when polyurethane film 1 is stretched by 15% at a speed of 10 O mm / min is measured did. This stress was taken as the elastic film following property of the adhesive tape, and was compared with the stress when the polyurethane film was stretched by 15%. The measurement atmosphere was a temperature of 23 ° C. and a relative humidity of 65%.

(2) Adhesive strength per client The adhesive strength of each adhesive tape having a width of 15 mm to the bare panel was measured in accordance with the JISZ-0 237 180 degree peeling method. The measurement atmosphere was a temperature of 23 ± 2 ° C and a relative humidity of 65 ± 5%.

(3) Moisture permeability

The moisture permeability of the adhesive tape was measured under the condition B of JISZ—0208 (temperature: 40 ° C., relative humidity: 90%).

(4) Adhesive displacement

Primer treatment (for example, polyester resin “Vylon 30 SS” manufactured by Toyobo Co., Ltd., about 3 m applied) is applied to a hard film surface with no elasticity such as PET # 36, and the adhesive of the adhesive tape is applied. It is the amount of shear deformation of the adhesive measured without interfacial slip (with the adherend) of the layer.

Specifically, as shown in FIG. 2, a base plate (or glass plate) 22 is fixed to the vertical surface of the support 21, and a primer-treated PET film 23 is placed on the surface. Bond so that the treated surface 24 faces up. Adhesive tape 25 is applied to this primer treated surface 24

2 Paste in 6. Make a cut 27 in the adhesive tape so that 12 × 20 mm 2 of the adhesive layer is attached to the primer-treated surface. Apply a 2 N load of 28 to the lower end of the adhesive tape 25. With this load applied

After a lapse of 30 minutes, the amount of displacement of the pressure-sensitive adhesive layer at the cut portion 27 was read with a microscope equipped with a scale, and was taken as the amount of pressure-sensitive adhesive displacement (n = 3).

3. Performance evaluation of adhesive tape

(1) Skin tracking

As shown in Fig. 3, two strips of non-stretchable non-stretchable 15 mm wide non-stretchable films 3 2 and 3 3 are applied to the inside of the forearms of six adult men for 20 mm. One non-stretchable film 32 was fixed at one end, and one end of the other non-stretchable film 33 was connected to a strain gauge 34 (digital force gauge). Apply 15 mm X 18 mm adhesive tape 35 between two non-stretch films at 1 mm intervals, and compare the stress when stretched 15% to the viscoelasticity of the skin It was evaluated and used as an index of skin followability. The measurement atmosphere was a temperature of 23 ± 2 ° C. and a relative humidity of 65% to 5%.

(2) Pain from skin adhesion, water retention, and exfoliation

Two 15 mm × 70 mm adhesive tapes were applied to the inside of the forearm of eight adult boys in the lateral direction. At 1 hour and 24 hours after application, the skin adhesive strength was measured at 90 ° peel angle using an Instron type tensile tester. The samples stuck for 24 hours were evaluated for water retention, pain during peeling, and skin irritation 1 hour after peeling. The water retention is measured by measuring the conductivity of the stratum corneum before and after application with SKIC ON 2000 (manufactured by IBS Co., Ltd.). evaluated. Pain at the time of exfoliation was asked in four stages (0: none, 1: mild pain, 2: severe pain, 3: unbearable pain) and expressed as an average value.

(3) Skin irritation index

The adhesive tape of 25 mmc /) was applied to the inside of the upper arm of 10 adult men. It was peeled off 24 hours after application, and skin irritation 1 hour after peeling was evaluated according to Japanese standards.

Here, the Japanese standard is the standard of the Japanese patch test research group. Specifically, the following 1, soil, +, +10, + +10, and +++++ are weighted to 0, 0.5, 1, 2, 3, and 4 points, respectively, and each subject The average value of the evaluation results was multiplied by 100 to obtain a skin irritation index.

<Judgment criteria> I: No response,

Sat: light erythema,

+: Erythema,

++: erythema + edema,

+ + +: Erythema + edema + papules,

+ + + +: Erythema + edema + papules, serous papules, vesicles.

[Example 1]

As an adhesive, an acrylic copolymer obtained by copolymerizing isononyl acrylate / methoxynonaethylene glycol acrylate / nonaethylene glycol methacrylate (83 parts 716 parts / 1 part) is used. An adhesive solution obtained by adding 0.6 parts of Colony L (manufactured by Nippon Polyurethane) to 100 parts of the copolymer (solid content) [solvent: toluene / ethyl acetate = 7Z3 (weight ratio); Concentration of 30% by weight].

This adhesive solution was applied on a separator having a surface treated with silicone to a thickness of 38 m after drying, and dried at 120 ° C. for 3 minutes. Thereafter, a polyolefin-based microporous film having a thickness of 80 m was bonded as a support to the surface of the pressure-sensitive adhesive layer, and aged at 50 for 1 week to prepare a pressure-sensitive adhesive tape for skin application.

[Example 2]

An adhesive tape for attaching chyle was prepared in the same manner as in Example 1 except that the hydroxyl group-containing monomer was changed to ethylene glycol methacrylate among the monomer components of the adhesive.

[Comparative Example 1]

As an adhesive, an acrylic copolymer obtained by copolymerizing isononyl acrylate Z methoxynonaethylene glycol acrylate nonaethylene glycol methacrylate (83 parts Z16 parts Z1 part) (B) An adhesive solution containing 0.6 part of Coronate L (manufactured by Nippon Polyurethane) added to 100 parts of the copolymer (solid content) [solvent: toluene Z ethyl acetate = 7 Z 3 (weight ratio); 30% by weight] was prepared.

This adhesive solution was applied on a separatory coated with silicone on the surface so as to have a thickness of 38 / m after drying, and dried at 120 ° C for 3 minutes. Then, an EMMA (ethylene monomethyl methacrylate copolymer) film with a thickness of 100 was adhered to the surface of the adhesive layer as a support, and aged at 50 ° C for 1 week to produce an adhesive tape for skin application. Made.

[Comparative Example 2]

Using an isononyl acrylate tonoacrylic acid (98 parts / 2 parts) copolymer as the adhesive, an adhesive solution [solvent: toluene / ethyl acetate = 7/3 (weight ratio); concentration 30% by weight] was prepared. did. This adhesive solution was applied on the surface of the separator, which had been subjected to silicone treatment, to a thickness of 38 m after drying, and dried at 120 ° C. for 3 minutes. Thereafter, a rayon nonwoven fabric having a thickness of 100 im was bonded as a support to the surface of the pressure-sensitive adhesive layer, and aged at 40 ° C. for one week to prepare a pressure-sensitive adhesive tape for skin application.

Dagger Comparative Example 3]

As an adhesive, a copolymer of isononyl acrylate tonoacrylic acid (96 parts, Z 4 parts) was used, and an adhesive solution [solvent: toluene Z ethyl acetate = 7/3 (weight ratio); concentration: 30% by weight ] Was prepared. This adhesive solution was applied on the surface of the separation treated with silicone on the surface so as to have a thickness of 38 m after drying, and dried at 120 for 3 minutes. Then, a 120-m-thick polyethylene film is adhered to the surface of the adhesive layer as a support, aged at 40 ° C for 1 week, Was prepared.

Table 1 shows the physical properties of the supports used in Examples 1 and 2 and Comparative Examples 1 to 3, Table 2 shows the properties of the obtained pressure-sensitive adhesive tapes, and Table 3 shows the performance evaluation results.

Support

1 5% tensile stress mm.

Thick (N / 15 recitation)

() D TD (M) (sec / 100cc) Example 1 80 7.8 2.1 1.4 210 4290 Example 2 80 7.8 2.1 1.4 210 4290 Comparative example 1 100 6.1 5.9 No hole 10 Comparative example 2 100 D ND ND 0.3 7920 Comparative example 3 120 11.6 11.5 No hole 10

Table 2

(Footnote)

* 1: The stress at 15% elongation of the stretchable film is 0.84 N / 15 mm. Magnification is the value obtained by dividing the stretchability of the adhesive tape (stress value) by the stress of the stretchable film at 15% elongation.

Table 3

(Footnote)

* 2: The stress (skin viscoelasticity) at 15% elongation of the skin is 0.31 NZ 15 mm

[Example 3]

As an adhesive, an acrylic copolymer obtained by copolymerizing isononyl acrylate / methoxynonaethylene glycol acrylate Z ethylene glycol acrylate (83 parts / 16 parts Z 1 part) was used. Copolymer (solid content) Adhesive solution containing 0.6 part of Colony L (manufactured by Japan Polyurethane Industry Co., Ltd.) added to 100 parts [Solvent: Toluene Z Ethyl acetate = 3 1 (Weight ratio); concentration: 30% by weight] (Adhesive ①) This adhesive solution was applied on a separator treated with silicone on its surface so that the thickness after drying was 38 ^ m. Coated and dried at 120 ° C for 3 minutes. Linear low-density polyethylene (density = 0.915 g / cm3) 100 parts, calcium carbonate 120 parts with average particle size 1.8, oleic acid 1.2 parts, and refined castor oil Eight parts were added, mixed well, extruded into a strand at 200 ° C by a twin-screw extruder, and pelletized. Using this pellet, the resin was melt-extruded in a sheet form from a T-die of an extruder at a resin temperature of 210 ° C. to obtain an unstretched sheet having a thickness of about 400 m. The unstretched sheet is reheated and biaxially stretched at a stretching temperature of 85 ° C by a ten-and-one stretching method in both the MD and TD directions at a draw ratio of about 3 times in both directions and cooled by chill rolls Thus, a biaxially stretched film (support A) having a thickness of 53 3 m was obtained.

One surface of this biaxially stretched film was adhered to the surface of the adhesive layer of the separator where the above-mentioned adhesive layer was applied by corona treatment, and aged at 50 ° C for 1 week to prepare a pressure-sensitive adhesive tape for skin application. .

[Example 4]

Ethylene-1 monohexene copolymer (density = 0.920 g / cm3) 100 parts of calcium carbonate with an average particle size of 1.1 xm 160 parts, oleic acid 1.2 And 7.8 parts of purified castor oil are mixed for 5 minutes using a supermixer, and then extruded into a strand at a resin temperature of 200 ° C by a twin-screw extruder and cut into pellets. did. Using this pellet, it was melt-extruded into a sheet from a T-die of an extruder at a resin temperature of 210 ° C. to obtain an unstretched sheet having a thickness of about 80 m. The unstretched sheet is reheated and stretched in a uniaxial direction at a stretching temperature of 85 ° C. by a roll stretching method at a draw ratio of about 2 times to obtain a 50-thick uniaxially stretched film (support B). Was prepared.

An adhesive tape for application to the skin was produced in the same manner as in Example 3, except that the above-prepared uniaxially stretched film was used as a support. [Example 5]

Mixture of 75 parts of ethylene-1-butene copolymer (density = 0.923 g / cm3) and 25 parts of high-pressure low-density polyethylene (density = 0.925 g κcm3) 10 To 0 part, 120 parts of calcium carbonate having an average particle size of 1.2 m, 1.2 parts of oleic acid, and 6 parts of refined castor oil were mixed for 5 minutes with a super mixer, and then mixed with a twin screw extruder. It was extruded into a strand at a resin temperature of 200 ° C. and cut into a pellet. Using this pellet, it was melt-extruded in a sheet form from a T-die of an extruder at a resin temperature of 210 ° C. to obtain an unstretched sheet having a thickness of about 12. This and the unstretched sheet reheated at a stretching temperature 8 5 ^D C, by a roll stretching method, by stretching uniaxially at approximately twice the draw ratio, uniaxially oriented film of Thickness 8 2 m (support Body C) was prepared.

An adhesive tape for application to the skin was produced in the same manner as in Example 3, except that the above-prepared uniaxially stretched film was used as a support.

[Example 6]

As the adhesive, an acrylic copolymer obtained by copolymerizing isononyl acrylate methoxy nona acrylate ethylene glycol Z-acrylate 2-alkoxypropyl (83 parts / 15 parts Z 2 parts) is used. Adhesive solution containing 0.06 parts of TET RAD-X (manufactured by Mitsubishi Gas Chemical Co., Ltd.) added to 100 parts of polymer (solid content) [Solvent: toluene Z ethyl acetate = 3 1 (weight) Ratio); concentration of 30% by weight] (adhesive ②). An adhesive tape for applying to skin was prepared in the same manner as in Example 3 except that this adhesive solution was used.

[Example 7]

As an adhesive, isononyl acrylate / methoxy nona ethylene glycol acrylate / 2-carboxyethyl acrylate (81 parts Z 15 (5 parts / 4 parts) was used, and 100 parts of the copolymer (solid content) was added to TET RAD—X [Mitsubishi Gas Chemical Co., Ltd.

Co., Ltd.] (0.08 parts) was added to prepare an adhesive solution (solvent: ethyl ethyl tolueneate = 31 (weight ratio); concentration: 30% by weight) (adhesive ③). A pressure-sensitive adhesive tape for application to skin was prepared in the same manner as in Example 3 except that this pressure-sensitive adhesive solution was used.

[Example 8]

As an adhesive, an acrylic copolymer obtained by copolymerizing isononyl acrylate Z methoxy nona ethylene glycol acrylate nona ethylene glycol nonamethacrylate (83 parts 16 parts 71 parts) is used. 0.6 part of Coronate L (manufactured by Nippon Polyurethane) was added to 100 parts of solid solution, and the adhesive solution was added [solvent: toluene / ethyl acetate = 3/1 (weight ratio); concentration: 30% by weight] Was prepared in the same manner as in Example 3 except that this adhesive solution was used, to prepare an adhesive tape for application to the skin.

[Comparative Example 4]

Except that, as the support, a polyolefin-based microporous film made of a resin composition containing polyethylene and an inorganic filler, POLYRAM PN 70 (support a) manufactured by Tokuyama Corporation was used. In the same manner as in Example 8, a pressure-sensitive adhesive tape for application to the skin was prepared.

[Comparative Example 5]

As a support, a polyolefin-based microporous film formed from a resin composition containing polyethylene and an inorganic filler was used except that POLLUM PH70 (support b) manufactured by Tokuyama Corporation was used. In the same manner as in Comparative Example 4, a pressure-sensitive adhesive tape for applying to skin was prepared. one

[Comparative Example 6]

Except that NF sheet NG100 (support c) manufactured by Tokuyama Corporation, which is a polyolefin-based microporous film formed from a resin composition containing polypropylene and an inorganic filler, was used as the support. In the same manner as in Comparative Example 4, a pressure-sensitive adhesive tape for application to the skin was produced.

[Comparative Example 7]

As an adhesive, an acrylic copolymer obtained by copolymerizing isononyl acrylatenoacrylic acid (96 parts / 4 parts) was used, and TETRAD-X [100 parts was added to 100 parts of the copolymer (solid part). Mitsubishi Gas Chemical Co., Ltd.] 0.04 parts of an adhesive solution [solvent: toluene Z-ethyl acetate-3Z1 (weight ratio); concentration: 30% by weight] was prepared (Adhesive ⑤). An adhesive tape for application to the skin was produced in the same manner as in Example 5, except that this adhesive solution was used.

[Comparative Example 8]

As an adhesive, an acrylic copolymer obtained by copolymerizing isononylacrylate methacrylate glycol / acrylic acid / acrylic acid (68 parts / 30 parts / 2 parts) was used. ) Add 100 parts of TET RAD-X (manufactured by Mitsubishi Gas Chemical Co., Ltd.) to 100 parts and add an adhesive solution [Solvent: toluene / ethyl acetate = 3/1 (weight ratio); Concentration: 30 % By weight) (adhesive ⑥). A pressure-sensitive adhesive tape for application to skin was prepared in the same manner as in Example 5, except that this pressure-sensitive adhesive solution was used.

Table 4 shows the physical properties of the supports used in Examples 3 to 8 and Comparative Examples 4 to 8, Table 5 shows the properties of the obtained pressure-sensitive adhesive tapes, and Table 6 shows the performance evaluation results. Table 4 Supports

1 5% tensile stress average permeability moisture thickness (N / 15 圆) T

ί _tM \

MD TD (Ui) (sec / lUUccj (g m4η) 夹夹 53 5.3 4.3 1.0 160 5000 A 4 4 50 4.4 1.0 u.a 11 u0 5500 n

D Otto也1 data ¹ jb 82 7.8 2.1 1.4 220 4270 Mr夹施1 Tari 53 5.3 4.3 l. O 160 5000 A real ΰ也例7 53 5.3 4.3 1.0 160 5000 A

r * r

Premature flSI Tali a 00 5.3 4.3 lbU 5UUU A Kushichi 1 Tali 4 fU 6.9 6.0 丄 >> 丄 oOU a 2.1 1.4 220 4270 C Comparative Example 8 82 7.8 2.1 1.4 220 4270 c

Table 5

(Footnote)

* 1: The stress at 15% elongation of the stretchable film is 0.84 NZ 15 mm. Magnification is the value obtained by dividing the stretchability of the adhesive tape (stress value) by the stress of the stretchable film at 15% elongation. Table 6

(Footnote)

* 2: The stress (skin viscoelasticity) at 15% elongation of the skin is 0 31 N / 15 mm Industrial applicability

ADVANTAGE OF THE INVENTION According to this invention, the adhesiveness at the time of perspiration and the sticking time at the time of sticking for a long time is stabilized, Furthermore, the pain at the time of peeling, exfoliation of a keratin, and the adhesive tape for skin sticking with little skin irritation are provided. The pressure-sensitive adhesive tape for application to the skin of the present invention has a skin-tracking property, a moisture permeability, and a skin-adhesive property all within an appropriate range, and these properties are highly balanced. Adhesion at the time of application is stable, and pain, exfoliation, and skin irritation during exfoliation are greatly reduced. Further, according to the present invention, there is provided a support suitable for a pressure-sensitive adhesive tape for applying to skin having such excellent properties. INDUSTRIAL APPLICABILITY The pressure-sensitive adhesive tape for application to the skin of the present invention is suitable for applications such as protection of affected areas of the skin and surgical sites, and percutaneous absorption of drugs.

Claims

The scope of the claims

1. A pressure-sensitive adhesive tape for application to the skin, wherein a pressure-sensitive adhesive layer is formed on at least one surface of a stretchable support having moisture permeability.

(a) Stretch film followability is less than 4.2 times the stretch film stress at 15% elongation,

(b) moisture permeability of 500 g / m2224 h or more, and

(c) Adhesive strength per client is 1.5 NZ 15 mm or less

An adhesive tape for adhering to skin, which is characterized in that:

2. (a) Stretch film followability is 2.4 to 4.2 times the stretch film stress at 15% elongation,

(b) The moisture permeability is 700 to 5, 000 g / m2 '24 h, and

(c) Adhesive strength per client is 0.6 to 1.5 N / 15 mm

The pressure-sensitive adhesive tape for adhering to skin according to claim 1, which is:

3. (d) adhesive deviation amount (mmZ 1 2 X 2 0 mm 2 · 2 N · 3 0 min) is 0. 1 5~:. L 2 0 skin patch according to claim 1 or 2 in mm Adhesive tape.

4. A microporous film formed from a resin composition containing a polyolefin-based resin and an inorganic filler, wherein the stretchable support having moisture permeability is provided,

(1) The thickness is 40 ~ 200m,

(2) The average pore size is 0.02 ~: L 0 m, (3) Air permeability is 10 to 400 sec / 100 cc,

(4) Moisture permeability is 1, 000--20, O O O g Zn ^ 'Z h, and

(5) The stress at the time of 15% extension in the machine direction and the width direction is 0.5 to 15 NZ 15 mm

3. The adhesive tape for sticking on skin according to claim 1 or 2, which is a microporous film.

5. The pressure-sensitive adhesive tape for application to the skin according to claim 1, wherein the pressure-sensitive adhesive layer is an acrylic pressure-sensitive adhesive layer.

6. When the acrylic adhesive is

(i) 50 to 97.5% by weight of an alkyl (meth) acrylate having an alkyl group having 4 to 12 carbon atoms,

(i 0 (meth) alkoxypolyalkylene glycol acrylate 2 to 49.5% by weight, and

(iii) The pressure-sensitive adhesive tape for application to skin according to claim 5, which is a copolymer having a hydroxyl group or carboxyl group-containing monomer of 0.5 to 15% by weight.

7. The (meth) alkoxypolyalkylene glycol acrylate is represented by the formula (1)

H ₂ C = C-C-0-(CH ₂ -CH-0) „-R ₃ (1)

II

0

(Wherein and R2 are each independently a hydrogen atom or a methyl group, R ₃ is an alkyl group of from 1 to 2 0 carbon atoms, n is integer from 2 to 1 2.) 7. The pressure-sensitive adhesive tape for skin application according to claim 6, which is a (meth) acrylate ester represented by the formula:

8. The pressure-sensitive adhesive tape for application to the skin according to claim 6, wherein the hydroxyl group-containing monomer is (meth) acrylic acid hydroxyalkyl ester.

9. The adhesive tape for application to the skin according to claim 6, wherein the monomer having a hydroxyl group is a carboxyalkyl (meth) acrylate.

10. The hydroxyl group-containing monomer is represented by the formula (2)

R ₄ R ₅

H ₂ C = C-C-1 0— (CH ₂ — CH— 0) _ra — H (2)

II

0

(In the formula, R ₄ and R ₅ are each independently a hydrogen atom or a methyl group, and m is an integer of 2 to 12.)

The pressure-sensitive adhesive tape for application to the skin according to claim 6, which is a hydroxyl group-containing (meth) acrylic acid ester represented by the formula:

1 1. The monomer containing a propyloxyl group has the formula (3)

R ₆

I

H ₂ C = C-C— 0— X-COOH (3)

0

(In the formula, R ₆ is a hydrogen atom or a methyl group, X is a divalent organic group having 2 or more carbon atoms, and includes a hetero atom such as an oxygen atom, a nitrogen atom, and a sulfur atom. Is also good.) The pressure-sensitive adhesive tape for application to skin according to claim 6, which is a carboxyl group-containing (meth) acrylate ester represented by the formula:

1 2. A microporous film formed from a resin composition containing a polyolefin resin and an inorganic filler,

(1) The thickness is 40 ~ 200z m,

(2) Average pore size is 0.02 ~ 10 / m,

(3) Air permeability is 10 ~ 40 0 se c Z l 0 0 c c,

(4) Moisture permeability is 1, 000 to 200, 000 g / m2 · 24h, and

A pressure-sensitive adhesive tape support for adhering to skin, comprising a microporous film.