[go: up one dir, main page]

WO2000031264A3 - Testis-specific cystatin-like protein cystatin t - Google Patents

Testis-specific cystatin-like protein cystatin t Download PDF

Info

Publication number
WO2000031264A3
WO2000031264A3 PCT/US1999/025519 US9925519W WO0031264A3 WO 2000031264 A3 WO2000031264 A3 WO 2000031264A3 US 9925519 W US9925519 W US 9925519W WO 0031264 A3 WO0031264 A3 WO 0031264A3
Authority
WO
WIPO (PCT)
Prior art keywords
cystatin
specific
testis
polypeptides
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/025519
Other languages
French (fr)
Other versions
WO2000031264A2 (en
Inventor
James L Holloway
Andrew L Feldhaus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU14591/00A priority Critical patent/AU1459100A/en
Priority to CA002364669A priority patent/CA2364669A1/en
Publication of WO2000031264A2 publication Critical patent/WO2000031264A2/en
Publication of WO2000031264A3 publication Critical patent/WO2000031264A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to cystatin T (also known as zcys3) polypeptides and polynucleotides encoding the same. Cystatin T polypeptide is testis specific and homologous to cystatin-related epididymal specific gene (CRES) and type 2 cystatins. The polypeptides would be useful for modulating spermatogenesis and may be used to study or modulate that function in in vitro or in vivo systems. The present invention also includes antibodies to the cystatin T polypeptides.
PCT/US1999/025519 1998-11-20 1999-11-01 Testis-specific cystatin-like protein cystatin t Ceased WO2000031264A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU14591/00A AU1459100A (en) 1998-11-20 1999-11-01 Testis-specific cystatin-like protein cystatin t
CA002364669A CA2364669A1 (en) 1998-11-20 1999-11-01 Testis-specific cystatin-like protein cystatin t

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19719598A 1998-11-20 1998-11-20
US09/197,195 1998-11-20

Publications (2)

Publication Number Publication Date
WO2000031264A2 WO2000031264A2 (en) 2000-06-02
WO2000031264A3 true WO2000031264A3 (en) 2000-10-19

Family

ID=22728426

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/025519 Ceased WO2000031264A2 (en) 1998-11-20 1999-11-01 Testis-specific cystatin-like protein cystatin t

Country Status (3)

Country Link
AU (1) AU1459100A (en)
CA (1) CA2364669A1 (en)
WO (1) WO2000031264A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001094388A2 (en) * 2000-06-05 2001-12-13 Zymogenetics, Inc. Zcys6: a member of the cystatin superfamily
WO2001094389A2 (en) * 2000-06-06 2001-12-13 Zymogenetics, Inc. Zcys7: a member of the cystatin superfamily
AU2002231077A1 (en) * 2000-12-19 2002-07-01 Glaxo Group Limited Novel compounds
WO2003100025A2 (en) 2002-05-28 2003-12-04 Regents Of The University Of Minnesota Crisp polypeptides as contraceptives and inhibitors of sperm capacitation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0373771A2 (en) * 1988-11-18 1990-06-20 Taisho Pharmaceutical Co. Ltd New pharmaceutical uses for cystatins
US5212297A (en) * 1989-05-16 1993-05-18 University Of Kansas cDNA clones encoding chicken egg white cystatin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0373771A2 (en) * 1988-11-18 1990-06-20 Taisho Pharmaceutical Co. Ltd New pharmaceutical uses for cystatins
US5212297A (en) * 1989-05-16 1993-05-18 University Of Kansas cDNA clones encoding chicken egg white cystatin

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
AFFARA ET AL: "The identification of novel gene sequences of the human adult testis", GENOMICS,US,ACADEMIC PRESS, SAN DIEGO, vol. 22, 1 January 1994 (1994-01-01), pages 205 - 210, XP002089680, ISSN: 0888-7543 *
CORNWALL, G.A. ET AL.: "The CRES gene: a unique testis-regulated gene related to the cystatin family is highly restricted in its expression to the proximal region of the mouse epididymis", MOLECULAR ENDOCRINOLOGY, vol. 6, no. 10, October 1992 (1992-10-01), pages 1653 - 1664, XP000886213 *
HUH C ET AL: "Structural organization, expression and chromosomal mapping of the mouse cystatin-C-encoding gene (Cst3)", GENE,NL,ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, vol. 152, no. 2, 23 January 1995 (1995-01-23), pages 221 - 226, XP004042680, ISSN: 0378-1119 *
SHOEMAKER, K. ET AL.: "Molecular cloning, chromosome mapping and characterization of a testis-specific cystatin-like cDNA, cystatin T", GENE, NL, ELSEVIER BIOMEDICAL PRESS, vol. 245, no. 1, 7 March 2000 (2000-03-07), pages 103-108, XP002135806 *
THIESSE, M.: "The human type-2 cystatin family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20", DNA AND CELL BIOLOGY, vol. 13, no. 2, February 1994 (1994-02-01), pages 97 - 116, XP000886234 *
TOEHOENEN V ET AL: "TESTATIN: A CYSTATIN-RELATED GENE EXPRESSED DURING EARLY TESTIS DEVELOPMENT", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 95, November 1998 (1998-11-01), pages 14208 - 14213, XP000857715, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2000031264A2 (en) 2000-06-02
AU1459100A (en) 2000-06-13
CA2364669A1 (en) 2000-06-02

Similar Documents

Publication Publication Date Title
AUPP051497A0 (en) Antimicrobial peptides
NZ504114A (en) Vitamin k-dependent polypeptides such as protein C where substitution at amino acid sites 11, 12, 29, 33 or 34 affects membrane binding affinity of the protein and ultimately blood clotting ability
WO1995021252A3 (en) Wd-40-derived peptides and uses thereof
CA2314129A1 (en) Luminescent protein stains containing transition metal complexes
PT101297A (en) GLITARY MITOGENIC FACTORS, THEIR PREPARATION AND UTILIZATION
CA2265976A1 (en) High level expression of proteins
WO1995033819A3 (en) Cdk4 (cyclin dependent kinase 4) binding proteins
IL113617A0 (en) Soluble polypeptide fraction
DE3884529D1 (en) LEADER SHARES FOR THE PRODUCTION OF RECOMBINANT PROTEINS.
WO1998021328A3 (en) Human proteins having transmembrane domains and dnas encoding these proteins
WO2000029427A3 (en) Antennapedia homeodomain helix 3 derived translocation vectors
EP1903112A3 (en) Activin receptors-like kinase(alk), belonging to the TGF receptor family and/or to the BMP receptor family
CA2270289A1 (en) Proteins with enhanced levels of essential amino acids
CA2232727A1 (en) Novel variants of green fluorescent protein, gfp
EP0832973A3 (en) GTP-binding protein
EP0769554A3 (en) Human CNP gene and precursor protein
AU6332399A (en) Member of the tnf ligand family
GB9606040D0 (en) Active peptide
WO2000031264A3 (en) Testis-specific cystatin-like protein cystatin t
CA2040441A1 (en) Fusion proteins
Jun et al. Almost derivations on the banach algebra $ C^ n $[0, 1]
CA2205892A1 (en) Mutant prenyl diphosphate synthase
WO2000018909A3 (en) NUCLEIC ACIDS AND PROTEINS FROM $i(CENARCHAEUM SYMBIOSUM)
EP0384731A3 (en) Osteogenic growth polypeptides identified from regenerating bone marrow
ATE301712T1 (en) Z2-19A, A HUMAN HOMOLOGUE OF THE PROTEIN 2-19

Legal Events

Date Code Title Description
ENP Entry into the national phase

Ref country code: AU

Ref document number: 2000 14591

Kind code of ref document: A

Format of ref document f/p: F

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/004974

Country of ref document: MX

ENP Entry into the national phase

Ref document number: 2364669

Country of ref document: CA

Ref country code: CA

Ref document number: 2364669

Kind code of ref document: A

Format of ref document f/p: F

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase