[go: up one dir, main page]

WO2000025763A3 - Phenolderivaten enthaltendes mittel mit proliferationshemmender wirkung auf tumorzellen - Google Patents

Phenolderivaten enthaltendes mittel mit proliferationshemmender wirkung auf tumorzellen Download PDF

Info

Publication number
WO2000025763A3
WO2000025763A3 PCT/DE1999/003524 DE9903524W WO0025763A3 WO 2000025763 A3 WO2000025763 A3 WO 2000025763A3 DE 9903524 W DE9903524 W DE 9903524W WO 0025763 A3 WO0025763 A3 WO 0025763A3
Authority
WO
WIPO (PCT)
Prior art keywords
proliferation
tumour cells
inhibiting effect
cells
phenol derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/DE1999/003524
Other languages
English (en)
French (fr)
Other versions
WO2000025763A2 (de
Inventor
Gerhard Bundschuh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MECKEL-SPENGLERSAN GmbH
MECKEL SPENGLERSAN GmbH
Original Assignee
MECKEL-SPENGLERSAN GmbH
MECKEL SPENGLERSAN GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MECKEL-SPENGLERSAN GmbH, MECKEL SPENGLERSAN GmbH filed Critical MECKEL-SPENGLERSAN GmbH
Publication of WO2000025763A2 publication Critical patent/WO2000025763A2/de
Publication of WO2000025763A3 publication Critical patent/WO2000025763A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/08—Oxides; Hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Die Erfindung betrifft die Bereitstellung von Mitteln mit proliferationshemmender Wirkung auf Tumorzellen. Die erfindungsgemäßen Mittel enthalten als wirksame Komponenten Phenolderivate, insbesondere Thymol, Eugenol, Hydroxybenzoesäuren bzw. deren Derivate sowie Gemische dieser Komponenten. Als Testzellen sind kultivierbare Tumorzellen menschlicher Herkunft, wie Lymphomzellen oder Melanomzellen, eingesetzt worden.
PCT/DE1999/003524 1998-10-30 1999-10-29 Phenolderivaten enthaltendes mittel mit proliferationshemmender wirkung auf tumorzellen Ceased WO2000025763A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19851706 1998-10-30
DE19851706.8 1998-10-30

Publications (2)

Publication Number Publication Date
WO2000025763A2 WO2000025763A2 (de) 2000-05-11
WO2000025763A3 true WO2000025763A3 (de) 2000-11-09

Family

ID=7887244

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/003524 Ceased WO2000025763A2 (de) 1998-10-30 1999-10-29 Phenolderivaten enthaltendes mittel mit proliferationshemmender wirkung auf tumorzellen

Country Status (2)

Country Link
DE (1) DE19954040A1 (de)
WO (1) WO2000025763A2 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9132103B2 (en) 2009-09-24 2015-09-15 Conopco, Inc. Disinfecting agent comprising eugenol, terpineol and thymol
US9408870B2 (en) 2010-12-07 2016-08-09 Conopco, Inc. Oral care composition

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2661169T3 (es) 2005-07-28 2018-03-27 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Compuestos de monofenol, bencenodiol, o sulfhidrilo para uso en el tratamiento de melanomas
CN103998011B (zh) 2011-11-03 2016-11-23 荷兰联合利华有限公司 个人清洁组合物
WO2020188547A1 (en) * 2019-03-21 2020-09-24 Universidade Nova De Lisboa Terpene based therapeutic deep eutectic system, method of obtaining and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4418796A1 (de) * 1993-06-02 1994-12-15 Colgate Palmolive Co Oral anwendbare und gegen Plaque und Gingivitis wirkende Zusammensetzungen
WO1996030003A1 (de) * 1995-03-30 1996-10-03 Werner Kreutz Arzneistoffe zur selektiven bekämpfung von tumorgewebe
US5753270A (en) * 1987-09-16 1998-05-19 Patrick A. Beauchamp Topical treatment of diseased skin disorders
JPH11315012A (ja) * 1998-03-04 1999-11-16 Shiseido Co Ltd サイクリックａｍｐ誘導剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753270A (en) * 1987-09-16 1998-05-19 Patrick A. Beauchamp Topical treatment of diseased skin disorders
DE4418796A1 (de) * 1993-06-02 1994-12-15 Colgate Palmolive Co Oral anwendbare und gegen Plaque und Gingivitis wirkende Zusammensetzungen
WO1996030003A1 (de) * 1995-03-30 1996-10-03 Werner Kreutz Arzneistoffe zur selektiven bekämpfung von tumorgewebe
JPH11315012A (ja) * 1998-03-04 1999-11-16 Shiseido Co Ltd サイクリックａｍｐ誘導剤

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"martindale 30th edition", PHARMACEUTICAL PRESS, XP002134890 *
BUCCELLATO, G. ET AL: "Possible cytolytic activity of p-methylisopropylphenol (thymol)and of som chemically related compounds", BOLL. - SOC. ITAL. BIOL. SPER. (1966), 42(24), 1890-3, XP000901383 *
BUCCELLATO, G.: "Routes of administration of p-methylisopropylphenol (thymol) and its 24-hr. urinary elimination", BOLL. - SOC. ITAL. BIOL. SPER. (1966), 42(24), 1886-90, XP000901382 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; OTA, MASAHIRO ET AL: "Cyclic AMP inducers for activation of tyrosinase and prevention of hair graying", XP002134891, retrieved from STN Database accession no. 131:327324 *
DATABASE WPI Section Ch Derwent World Patents Index; Class B07, AN 1970-67604R, XP002134892 *
SIVROPOULOU, AFRODITI ET AL: "Antimicrobial and cytotoxic activities of Origanum essential oils", J. AGRIC. FOOD CHEM. (1996), 44(5), 1202-5, XP000583841 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9132103B2 (en) 2009-09-24 2015-09-15 Conopco, Inc. Disinfecting agent comprising eugenol, terpineol and thymol
US9408870B2 (en) 2010-12-07 2016-08-09 Conopco, Inc. Oral care composition

Also Published As

Publication number Publication date
DE19954040A1 (de) 2000-05-04
WO2000025763A2 (de) 2000-05-11

Similar Documents

Publication Publication Date Title
AU747599C (en) Antitumor agents
DE69939864D1 (de) Ppar-gamma modulatoren
AR020345A1 (es) Pirazol-carboxanilidas, procedimiento para su obtencion, composiciones, empleo de dichos compuestos y procedimiento para la lucha contra microorganismos indeseables, y procedimiento para la obtencion de dichas composiciones.
GEP20063885B (en) Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
MX9800782A (es) Composiciones para la liberacion topica de ingredientes activos.
DE60018179D1 (de) Silikongel enthaltend salizylsäure
ATE146360T1 (de) Gonadotropin enthaltende gefriergetrocknete troepfen
BE2015C026I2 (en) 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indole in combination with estrogens
AU4718496A (en) Use of aerogels in agriculture
YU23102A (sh) Jedinjenja za lečenje ishemije
TR200103241T2 (tr) Yüksek katı içerikli gıda bileşimi
WO1996035784A3 (de) Chromatin-regulatorgene
ES2191174T3 (es) (-)hidroxicitrato de magnesio, procedimiento de preparacion, aplicaciones y composiciones principalmente farmaceuticas que lo contienen.
SE9201628D0 (sv) Pharmaceutical composition
AU1648601A (en) Cosmetics
EP0841065A3 (de) Verwendung von Sericin als Antioxidantien und Tyrosinase-Inhibitoren
AU1095901A (en) Tissue products containing antiviral agents which are mild to the skin
PL308142A1 (en) Derivatives of 2-amino-4phenyl-4-oxobutyric acids as kynureninase and/or kynurenic 3-hydroxylase inhibitors
MXPA02003398A (es) Composiciones aromatizantes antimicrobianas.
GR3024667T3 (en) Cosmetical or pharmaceutical compositions comprising deacylated glycerophospholipids for topical use.
NZ319138A (en) Composition containing cytochrome complex III and fenazaquin for combatting parasitic fungi
IL139318A (en) Sugar alcohol mixtures as therapeutic agents and pharmaceutical compositions containing the same
WO2000025763A3 (de) Phenolderivaten enthaltendes mittel mit proliferationshemmender wirkung auf tumorzellen
DK0977871T3 (da) Neurotrypsin
AU4779599A (en) Methods of inhibiting (helicobacter pylori)

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

122 Ep: pct application non-entry in european phase