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WO2000023589A3 - Proliferation and apoptosis related proteins - Google Patents

Proliferation and apoptosis related proteins Download PDF

Info

Publication number
WO2000023589A3
WO2000023589A3 PCT/US1999/024511 US9924511W WO0023589A3 WO 2000023589 A3 WO2000023589 A3 WO 2000023589A3 US 9924511 W US9924511 W US 9924511W WO 0023589 A3 WO0023589 A3 WO 0023589A3
Authority
WO
WIPO (PCT)
Prior art keywords
related proteins
proliferation
proap
apoptosis related
provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/024511
Other languages
French (fr)
Other versions
WO2000023589A2 (en
Inventor
Y Tom Tang
Henry Yue
Jennifer L Hillman
Karl J Guegler
Neil C Corley
Preeti Lal
Yalda Azimzai
Mariah R Baughn
Junming Yang
Leo L Shih
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Incyte Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Pharmaceuticals Inc filed Critical Incyte Pharmaceuticals Inc
Priority to JP2000577298A priority Critical patent/JP2003524382A/en
Priority to EP99955070A priority patent/EP1123394A2/en
Priority to AU11260/00A priority patent/AU1126000A/en
Priority to CA002347836A priority patent/CA2347836A1/en
Publication of WO2000023589A2 publication Critical patent/WO2000023589A2/en
Publication of WO2000023589A3 publication Critical patent/WO2000023589A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides human proliferation and apoptosis related proteins (PROAP) and polynucleotides which identify and encode PROAP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of PROAP.
PCT/US1999/024511 1998-10-20 1999-10-19 Proliferation and apoptosis related proteins Ceased WO2000023589A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000577298A JP2003524382A (en) 1999-02-04 1999-10-19 Cell proliferation and apoptosis-related proteins
EP99955070A EP1123394A2 (en) 1998-10-20 1999-10-19 Proliferation and apoptosis related proteins
AU11260/00A AU1126000A (en) 1998-10-20 1999-10-19 Proliferation and apoptosis related proteins
CA002347836A CA2347836A1 (en) 1998-10-20 1999-10-19 Proliferation and apoptosis related proteins

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US17221698P 1998-10-20 1998-10-20
US60/172,216 1998-10-20
US11855999P 1999-02-04 1999-02-04
US60/118,559 1999-02-04
US17222999P 1999-02-11 1999-02-11
US60/172,229 1999-02-11
US15433699P 1999-04-22 1999-04-22
US60/154,336 1999-04-22

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09807452 A-371-Of-International 2001-04-11
US10/839,882 Division US20040203106A1 (en) 1999-01-19 2004-05-05 Signal peptide-containing molecules

Publications (2)

Publication Number Publication Date
WO2000023589A2 WO2000023589A2 (en) 2000-04-27
WO2000023589A3 true WO2000023589A3 (en) 2000-09-28

Family

ID=27494206

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024511 Ceased WO2000023589A2 (en) 1998-10-20 1999-10-19 Proliferation and apoptosis related proteins

Country Status (4)

Country Link
EP (1) EP1123394A2 (en)
AU (1) AU1126000A (en)
CA (1) CA2347836A1 (en)
WO (1) WO2000023589A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5544500A (en) * 1999-06-15 2001-01-02 Astrazeneca Ab Livin; inhibitor-of-apoptosis protein-3 (iap-3)
EP1103608A1 (en) * 1999-11-25 2001-05-30 Sanofi-Synthelabo CIDE-like protein, its isolation and uses
AU2001294267A1 (en) * 2000-10-17 2002-04-29 Takeda Chemical Industries Ltd. Survivin-like polypeptides and dnas thereof
US7317085B2 (en) * 2001-01-22 2008-01-08 Shinae Kondoh Human apoptosis-associated genes and human apoptosis-associated proteins produced thereby
WO2002062958A2 (en) * 2001-02-08 2002-08-15 Tularik Inc. Prc17: an amplified cancer gene
WO2002086076A2 (en) * 2001-04-19 2002-10-31 Bristol-Myers Squibb Company Polynucleotides and polypeptides associated with the nf-kb pathway
EP1365242A1 (en) * 2002-05-21 2003-11-26 MTM Laboratories AG Compounds for detection and treatment of colorectal lesions
US8163292B2 (en) 2007-02-16 2012-04-24 Virttu Biologics Limited Herpes simplex viruses and methods of viral replication
WO2023178241A2 (en) * 2022-03-16 2023-09-21 The Regents Of The University Of Colorado A Body Corporate Methods and compositions for disrupting tau aggregates using polyserine repeat sequences targeting exogenous proteins

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997045128A1 (en) * 1996-05-29 1997-12-04 Apoptosis Technology, Inc. Apoptosis associated protein bbk
WO1998005347A1 (en) * 1996-07-22 1998-02-12 The Trustees Of Columbia University In The City Of New York Compounds that inhibit interaction between signal-transducing proteins and the glgf (pdz/dhr) domain and uses thereof
WO1998011256A1 (en) * 1996-09-13 1998-03-19 The Trustees Of Columbia University In The City Ofnew York Beclin, a novel bcl-2 interacting gene near brca1 on chromosome 17q21 and methods of use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997045128A1 (en) * 1996-05-29 1997-12-04 Apoptosis Technology, Inc. Apoptosis associated protein bbk
WO1998005347A1 (en) * 1996-07-22 1998-02-12 The Trustees Of Columbia University In The City Of New York Compounds that inhibit interaction between signal-transducing proteins and the glgf (pdz/dhr) domain and uses thereof
WO1998011256A1 (en) * 1996-09-13 1998-03-19 The Trustees Of Columbia University In The City Ofnew York Beclin, a novel bcl-2 interacting gene near brca1 on chromosome 17q21 and methods of use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DESBARATS, L. ET AL.: "Myc: a single gene controls both proliferation and apoptosis in mammalian cells", EXPERIENTIA, vol. 15, no. 52, December 1996 (1996-12-01), pages 1123 - 1129, XP000882427 *
GALIANA E ET AL: "Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1995 FEB 28) 92 (5) 1560-4., XP002133326 *

Also Published As

Publication number Publication date
AU1126000A (en) 2000-05-08
EP1123394A2 (en) 2001-08-16
WO2000023589A2 (en) 2000-04-27
CA2347836A1 (en) 2000-04-27

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