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WO2000015773A3 - Inhibition of oncogene transcription by synthetic polyamides - Google Patents

Inhibition of oncogene transcription by synthetic polyamides Download PDF

Info

Publication number
WO2000015773A3
WO2000015773A3 PCT/US1999/020489 US9920489W WO0015773A3 WO 2000015773 A3 WO2000015773 A3 WO 2000015773A3 US 9920489 W US9920489 W US 9920489W WO 0015773 A3 WO0015773 A3 WO 0015773A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibition
synthetic polyamides
polyamide
polyamides
oncogene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/020489
Other languages
French (fr)
Other versions
WO2000015773A9 (en
WO2000015773A2 (en
Inventor
Peter B Dervan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology
Original Assignee
California Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology filed Critical California Institute of Technology
Priority to AU59108/99A priority Critical patent/AU5910899A/en
Priority to CA002342278A priority patent/CA2342278A1/en
Priority to JP2000570300A priority patent/JP2003505521A/en
Priority to EP99946779A priority patent/EP1112267A2/en
Publication of WO2000015773A2 publication Critical patent/WO2000015773A2/en
Publication of WO2000015773A3 publication Critical patent/WO2000015773A3/en
Anticipated expiration legal-status Critical
Publication of WO2000015773A9 publication Critical patent/WO2000015773A9/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Polyamides capable of inhibiting the transcription of oncogenes are provided. Preferred polyamides comprising at least three complementary pairs of aromatic carboxamide residues bind in the minor groove of double-stranded DNA. With regard to each polyamide, the complementary pairing of some or all of the polyamide's aromatic carboxamide residues determines the target nucleotide sequence of an identified dsDNA target in the promoter region of an oncogene.
PCT/US1999/020489 1998-09-11 1999-09-10 Inhibition of oncogene transcription by synthetic polyamides Ceased WO2000015773A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU59108/99A AU5910899A (en) 1998-09-11 1999-09-10 Inhibition of oncogene transcription by synthetic polyamides
CA002342278A CA2342278A1 (en) 1998-09-11 1999-09-10 Inhibition of oncogene transcription by synthetic polyamides
JP2000570300A JP2003505521A (en) 1998-09-11 1999-09-10 Inhibition of oncogene transcription by synthetic polyamides
EP99946779A EP1112267A2 (en) 1998-09-11 1999-09-10 Inhibition of oncogene transcription by synthetic polyamides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9985498P 1998-09-11 1998-09-11
US60/099,854 1998-09-11

Publications (3)

Publication Number Publication Date
WO2000015773A2 WO2000015773A2 (en) 2000-03-23
WO2000015773A3 true WO2000015773A3 (en) 2000-08-17
WO2000015773A9 WO2000015773A9 (en) 2002-04-25

Family

ID=22276927

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/020489 Ceased WO2000015773A2 (en) 1998-09-11 1999-09-10 Inhibition of oncogene transcription by synthetic polyamides

Country Status (5)

Country Link
EP (1) EP1112267A2 (en)
JP (1) JP2003505521A (en)
AU (1) AU5910899A (en)
CA (1) CA2342278A1 (en)
WO (1) WO2000015773A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002088119A1 (en) 2001-04-26 2002-11-07 Genesoft Pharmaceuticals, Inc Halogen-substituted thienyl compounds
WO2002100852A1 (en) 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc. Benzothiophene compounds having antiinfective activity
AU2002312370A1 (en) 2001-06-13 2002-12-23 Roland W. Burli Antipathogenic benzamide compounds
AU2002312371A1 (en) 2001-06-13 2002-12-23 Roland W. Burli Aryl-benzimidazole compounds having antiinfective activity
JP2005505507A (en) 2001-06-13 2005-02-24 ジーンソフト ファーマシューティカルズ インコーポレイテッド Isoquinoline compounds having anti-infective activity
US7498349B2 (en) 2002-08-02 2009-03-03 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
WO2004039318A2 (en) 2002-10-25 2004-05-13 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
US7129214B2 (en) 2002-12-10 2006-10-31 Oscient Pharmaceuticals Corporation Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
JPWO2007034784A1 (en) * 2005-09-20 2009-03-26 学校法人日本大学 CTGF gene expression inhibitor
WO2007103584A2 (en) * 2006-03-09 2007-09-13 Nanovir, Llc Polyamides for treating human papilloma virus
US8993609B2 (en) 2006-05-04 2015-03-31 Nanovir, Llc Compounds for treating papilloma virus infection
WO2007130616A2 (en) 2006-05-04 2007-11-15 Nanovir, Llc Polyamides for treating human papilloma virus
BR112014008464A2 (en) 2011-10-10 2017-04-11 Nanovir Llc compound; pharmaceutical composition; method for linking sequence-specific double-stranded DNA; method for reducing or inhibiting the proliferation of papilloma or neoplastic cells; method for treating virus infected cells; and method for treating hpv in an individual
US9982020B2 (en) 2011-10-10 2018-05-29 Nanovir Llc Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses
US10723716B2 (en) 2016-12-21 2020-07-28 New York University Alpha-helix mimetics as modulators of Abeta self-assembly

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035702A1 (en) * 1996-08-01 1998-08-20 California Institute Of Technology Inhibition of gene transcription by polyamide dna-binding ligands
WO1998037066A1 (en) * 1996-02-26 1998-08-27 California Institute Of Technology Improved polyamides for binding in the minor groove of double stranded dna
WO1998037067A1 (en) * 1996-02-26 1998-08-27 California Institute Of Technology Design, synthesis and use of specific polyamide dna-binding ligands
WO1998049142A1 (en) * 1997-04-06 1998-11-05 California Institute Of Technology Dna-binding pyrrole and imidazole polyamide derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037066A1 (en) * 1996-02-26 1998-08-27 California Institute Of Technology Improved polyamides for binding in the minor groove of double stranded dna
WO1998037067A1 (en) * 1996-02-26 1998-08-27 California Institute Of Technology Design, synthesis and use of specific polyamide dna-binding ligands
WO1998035702A1 (en) * 1996-08-01 1998-08-20 California Institute Of Technology Inhibition of gene transcription by polyamide dna-binding ligands
WO1998049142A1 (en) * 1997-04-06 1998-11-05 California Institute Of Technology Dna-binding pyrrole and imidazole polyamide derivatives

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
D. M. HERMAN ET AL: "Tandem hairpin motif for recognition in the minor groove of DNA by pyrrole-imidazole polyamides", CHEMISTRY - A EUROPEAN JOURNAL., vol. 5, no. 3, 1999, VCH PUBLISHERS., US, pages 975 - 983, XP002134479, ISSN: 0947-6539 *
D. M.HERMAN ET AL: "Stereochemical control of the DNA binding affinity, sequence specificity, and orientation preference of chiral hairpin polyamides in the minor groove", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 120, no. 7, 25 February 1998 (1998-02-25), DC US, pages 1382 - 1391, XP002077249 *
J.M. TURNER ET AL: "Aliphatic/aronatic amino acid pairings for polyamide recognition in the minor groove of DNA", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 120, no. 25, 1 July 1998 (1998-07-01), DC US, pages 6219 - 6226, XP002134477 *
L. A. DICKINSON ET AL: "Anti-repression of RNA polymerase II transcripion by pyrrole-imidazole polyamides", BIOCHEMISTRY., vol. 38, no. 33, 17 August 1999 (1999-08-17), AMERICAN CHEMICAL SOCIETY. EASTON, PA., US, pages 10801 - 10807, XP002134478, ISSN: 0006-2960 *

Also Published As

Publication number Publication date
AU5910899A (en) 2000-04-03
JP2003505521A (en) 2003-02-12
CA2342278A1 (en) 2000-03-23
WO2000015773A2 (en) 2000-03-23
EP1112267A2 (en) 2001-07-04

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