[go: up one dir, main page]

WO2000011168A3 - Genes that regulate hematopoietic blood forming stem cells and uses thereof - Google Patents

Genes that regulate hematopoietic blood forming stem cells and uses thereof Download PDF

Info

Publication number
WO2000011168A3
WO2000011168A3 PCT/US1999/019052 US9919052W WO0011168A3 WO 2000011168 A3 WO2000011168 A3 WO 2000011168A3 US 9919052 W US9919052 W US 9919052W WO 0011168 A3 WO0011168 A3 WO 0011168A3
Authority
WO
WIPO (PCT)
Prior art keywords
present
provides
stem cell
hematopoietic stem
stem cells
Prior art date
Application number
PCT/US1999/019052
Other languages
French (fr)
Other versions
WO2000011168A2 (en
Inventor
Ihor Lemischka
Kateri Moore
Original Assignee
Univ Princeton
Ihor Lemischka
Kateri Moore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Princeton, Ihor Lemischka, Kateri Moore filed Critical Univ Princeton
Priority to EP99945125A priority Critical patent/EP1105482A2/en
Priority to CA002340465A priority patent/CA2340465A1/en
Priority to JP2000566422A priority patent/JP2002523044A/en
Priority to AU57809/99A priority patent/AU5780999A/en
Publication of WO2000011168A2 publication Critical patent/WO2000011168A2/en
Publication of WO2000011168A3 publication Critical patent/WO2000011168A3/en
Priority to US09/789,919 priority patent/US20020064855A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides an isolated nucleic acid derived from an isolated hematopoietic stem cell. The present invention additionally provides an isolated hematopoietic stem cell specific protein or a portion thereof encoded by the provided nucleic acid. In addition, the present invention provides a method for generating a stem cell/progenitor cell from a primitive hematopoietic cell. Also, the present invention further provides a method for identifying the presence in a sample of a compound that modulates hematopoietic stem cell activity. The present invention additionally provides a molecularly defined primitive hematopoietic stem cell. Finally, the present invention provides a method of ex vivo expansion of hematopoietic stem cells.
PCT/US1999/019052 1998-08-21 1999-08-20 Genes that regulate hematopoietic blood forming stem cells and uses thereof WO2000011168A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP99945125A EP1105482A2 (en) 1998-08-21 1999-08-20 Genes that regulate hematopoietic blood forming stem cells and uses thereof
CA002340465A CA2340465A1 (en) 1998-08-21 1999-08-20 Genes that regulate hematopoietic blood forming stem cells and uses thereof
JP2000566422A JP2002523044A (en) 1998-08-21 1999-08-20 Genes regulating hematopoietic stem cells forming blood and uses thereof
AU57809/99A AU5780999A (en) 1998-08-21 1999-08-20 Genes that regulate hematopoietic blood forming stem cells and uses thereof
US09/789,919 US20020064855A1 (en) 1999-08-20 2001-02-21 Genes that regulate hematopoietic blood forming stem cells and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13813298A 1998-08-21 1998-08-21
US09/138,132 1998-08-21

Publications (2)

Publication Number Publication Date
WO2000011168A2 WO2000011168A2 (en) 2000-03-02
WO2000011168A3 true WO2000011168A3 (en) 2000-06-22

Family

ID=22480559

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/019052 WO2000011168A2 (en) 1998-08-21 1999-08-20 Genes that regulate hematopoietic blood forming stem cells and uses thereof

Country Status (5)

Country Link
EP (1) EP1105482A2 (en)
JP (1) JP2002523044A (en)
AU (1) AU5780999A (en)
CA (1) CA2340465A1 (en)
WO (1) WO2000011168A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7160679B1 (en) 1998-05-21 2007-01-09 Diadexus, Inc. Method of diagnosing, monitoring, and staging lung cancer

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001275163A1 (en) * 2000-06-02 2001-12-17 Massachusetts Institute Of Technology A tumor suppressor pathway in c. elegans
US20020082191A1 (en) * 2000-12-08 2002-06-27 Karl Guegler Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
WO2011040500A1 (en) 2009-09-29 2011-04-07 国立大学法人九州大学 Peptide inhibiting differentiation of hematopoietic stem cells or hematopoietic precursor cells and use of same
JP6663428B2 (en) 2014-10-30 2020-03-11 アクセルロン ファーマ， インコーポレイテッド Methods and compositions for increasing red blood cells using a GDF15 polypeptide

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK 11 December 1996 (1996-12-11), MARRA M.: "EST; mouse lymph node cDNA clone IMAGE:634660 similar to B-cell activation protein BL34", XP002126589 *
HONG J.X. ET AL.: "Isolation and characterization of a novel B-cell activation gene.", J. IMMUNOL., vol. 150, no. 9, 1993, pages 3895 - 3904, XP002126588 *
MATTHEWS W ET AL: "A RECEPTOR TYROSINE KINASE SPECIFIC TO HEMATOPOIETIC STEM AND PROGENITOR CELL-ENRICHED POPULATIONS", CELL,US,CELL PRESS, CAMBRIDGE, NA, vol. 65, no. 7, pages 1143-1152, XP000615979, ISSN: 0092-8674 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7160679B1 (en) 1998-05-21 2007-01-09 Diadexus, Inc. Method of diagnosing, monitoring, and staging lung cancer

Also Published As

Publication number Publication date
EP1105482A2 (en) 2001-06-13
WO2000011168A2 (en) 2000-03-02
JP2002523044A (en) 2002-07-30
CA2340465A1 (en) 2000-03-02
AU5780999A (en) 2000-03-14

Similar Documents

Publication Publication Date Title
TW428026B (en) Bifunctional protein, preparation and use
DE69812420D1 (en) ENZYMATIC PRODUCTION OF HOMOGENTISIC ACID
AU5488501A (en) Modified es cells and es cell-specific gene
WO2001079462A3 (en) Nucleic acids encoding polypeptides having haloperoxidase activity
WO2003014347A3 (en) Plant seed specific promoters
CA2315274A1 (en) Polypeptides having aminopeptidase activity and nucleic acids encoding same
WO2000046585A3 (en) Method for enriching or depleting tumour cells obtained from a body fluid and kit suitable for this purpose
DE60213803D1 (en) Happier mapping
WO2003050260A3 (en) Streptavidin expressed gene fusions and methods of use thereof
WO1999067382A3 (en) Angiopoietin-like growth factor sequences
WO1999042596A3 (en) Phosphodiesterase 10
WO1999020747A3 (en) HUMAN CHECKPOINT KINASE, hCDS1, COMPOSITIONS AND METHODS
EP0821064A3 (en) Recombinant fructosyl amino acid oxidase
AU7489098A (en) Polypeptides having aminopeptidase activity and nucleic acids encoding same
WO1996007739A3 (en) Interleukin-1 type 3 receptors
EP1304123A3 (en) Methods for the modulation of the growth of collateral arteries and/or other arteries from preexisting arteriolar connections
AU5559499A (en) Identification of the gene causing the mouse scurfy phenotype and its human ortholog
GB2399819A (en) Method of transducing es cells
WO2000029551A3 (en) Cells, culture methods, and their use in autologous transplantation therapy
WO2000011168A3 (en) Genes that regulate hematopoietic blood forming stem cells and uses thereof
WO2001049721A3 (en) Bacterial genes and proteins that are essential for cell viability and their uses
CA2349529A1 (en) Pge synthase and methods and means for modulating its activity
WO2003006669A3 (en) Efficient methods for assessing and validating candidate protein-based therapeutic molecules encoded by nucleic acid sequences of interest
EP1757684A3 (en) A 2,6-beta-D-fructan hydrolase enzyme and processes for using the enzyme
AU2001238064A1 (en) 18477, a human protein kinase and uses therefor

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
ENP Entry into the national phase

Ref document number: 2340465

Country of ref document: CA

Ref country code: CA

Ref document number: 2340465

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 09789919

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 1999945125

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1999945125

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 1999945125

Country of ref document: EP