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WO2000009100A3 - Benzothiepine compounds as enhancer of cell differentiation induction factor - Google Patents

Benzothiepine compounds as enhancer of cell differentiation induction factor Download PDF

Info

Publication number
WO2000009100A3
WO2000009100A3 PCT/JP1999/004338 JP9904338W WO0009100A3 WO 2000009100 A3 WO2000009100 A3 WO 2000009100A3 JP 9904338 W JP9904338 W JP 9904338W WO 0009100 A3 WO0009100 A3 WO 0009100A3
Authority
WO
WIPO (PCT)
Prior art keywords
enhancer
cell differentiation
differentiation induction
induction factor
benzothiepine compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP1999/004338
Other languages
French (fr)
Other versions
WO2000009100A2 (en
Inventor
Haruhiko Makino
Yukio Fujisawa
Masatoshi Hazama
Takashi Sohda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to AU51960/99A priority Critical patent/AU5196099A/en
Priority to CA002340165A priority patent/CA2340165A1/en
Priority to EP99937019A priority patent/EP1105140A2/en
Publication of WO2000009100A2 publication Critical patent/WO2000009100A2/en
Publication of WO2000009100A3 publication Critical patent/WO2000009100A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/67—Phosphorus compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention provides an enhancer of cell differentiation induction factor comprising a compound of formula (I), wherein ring A is an optionally substituted benzene ring; R is a hydrogen atom or an optionally substituted hydrocarbon group; B is an optionally esterified or amidated carboxyl group; X is -CH(OH)- or -CO-; k is 0 or 1; and k' is 0, 1 or 2, or its salt, which can be advantageously used as an enhancer of cell differentiation induction factor.
PCT/JP1999/004338 1998-08-12 1999-08-11 Benzothiepine compounds as enhancer of cell differentiation induction factor Ceased WO2000009100A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU51960/99A AU5196099A (en) 1998-08-12 1999-08-11 Enhancer of cell differentiation induction factor
CA002340165A CA2340165A1 (en) 1998-08-12 1999-08-11 Enhancer of cell differentiation induction factor
EP99937019A EP1105140A2 (en) 1998-08-12 1999-08-11 Benzothiepine compounds as enhancer of cell differentiation induction factor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10/228300 1998-08-12
JP22830098 1998-08-12

Publications (2)

Publication Number Publication Date
WO2000009100A2 WO2000009100A2 (en) 2000-02-24
WO2000009100A3 true WO2000009100A3 (en) 2000-08-24

Family

ID=16874304

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1999/004338 Ceased WO2000009100A2 (en) 1998-08-12 1999-08-11 Benzothiepine compounds as enhancer of cell differentiation induction factor

Country Status (5)

Country Link
EP (1) EP1105140A2 (en)
AR (1) AR020158A1 (en)
AU (1) AU5196099A (en)
CA (1) CA2340165A1 (en)
WO (1) WO2000009100A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0460488A1 (en) * 1990-05-30 1991-12-11 Takeda Chemical Industries, Ltd. Sulfur-containing heterocyclic compounds
EP0719782A1 (en) * 1994-12-28 1996-07-03 Takeda Chemical Industries, Ltd. Optically active benzothiepin derivative, its preparation and use
WO1996025929A1 (en) * 1995-02-21 1996-08-29 Takeda Chemical Industries, Ltd. Use of helioxanthin as an enhancer of cell differentiation inducing factors
WO1996039134A1 (en) * 1995-06-05 1996-12-12 Takeda Chemical Industries, Ltd. Osteogenetic promoting pharmaceutical composition
WO1998008517A2 (en) * 1996-08-26 1998-03-05 Takeda Chemical Industries, Ltd. Pharmaceutical composition containing osteogenesis-promoting substance and a polyethylene glycol
WO1998009958A1 (en) * 1996-09-06 1998-03-12 Takeda Chemical Industries, Ltd. Condensed 4,5,6,7-tetrahydrobenzo[c]thiophenes as enhancer for cell differentiation induction factor action

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0460488A1 (en) * 1990-05-30 1991-12-11 Takeda Chemical Industries, Ltd. Sulfur-containing heterocyclic compounds
EP0719782A1 (en) * 1994-12-28 1996-07-03 Takeda Chemical Industries, Ltd. Optically active benzothiepin derivative, its preparation and use
WO1996025929A1 (en) * 1995-02-21 1996-08-29 Takeda Chemical Industries, Ltd. Use of helioxanthin as an enhancer of cell differentiation inducing factors
WO1996039134A1 (en) * 1995-06-05 1996-12-12 Takeda Chemical Industries, Ltd. Osteogenetic promoting pharmaceutical composition
WO1998008517A2 (en) * 1996-08-26 1998-03-05 Takeda Chemical Industries, Ltd. Pharmaceutical composition containing osteogenesis-promoting substance and a polyethylene glycol
WO1998009958A1 (en) * 1996-09-06 1998-03-12 Takeda Chemical Industries, Ltd. Condensed 4,5,6,7-tetrahydrobenzo[c]thiophenes as enhancer for cell differentiation induction factor action

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AKIYAMA H ET AL: "TAK-778, a novel synthetic 3-benzothiepin derivative, promotes chondrogenesis in vitro and in vivo.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (1999 JUL 22) 261 (1) 131-8., XP000867478 *
KUROKAWA T. ET AL: "A one-step enzyme-linked immunosorbent assay for a novel osteoblast differentiation-promoting compound, TAK-778 in serum.", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, (1999) 22/12 (1266-1270)., December 1999 (1999-12-01), XP000884225 *
ODA, TSUNEO ET AL: "Synthesis of Novel 2-Benzothiopyran and 3-Benzothiepin Derivatives and Their Stimulatory Effect on Bone Formation", J. MED. CHEM. (1999), 42(4), 751-760, July 1999 (1999-07-01), XP000867476 *

Also Published As

Publication number Publication date
AU5196099A (en) 2000-03-06
EP1105140A2 (en) 2001-06-13
CA2340165A1 (en) 2000-02-24
AR020158A1 (en) 2002-04-10
WO2000009100A2 (en) 2000-02-24

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