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WO2000008202A3 - 3-methylidenyl-2-indolinone modulators of protein kinase - Google Patents

3-methylidenyl-2-indolinone modulators of protein kinase Download PDF

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Publication number
WO2000008202A3
WO2000008202A3 PCT/US1999/017845 US9917845W WO0008202A3 WO 2000008202 A3 WO2000008202 A3 WO 2000008202A3 US 9917845 W US9917845 W US 9917845W WO 0008202 A3 WO0008202 A3 WO 0008202A3
Authority
WO
WIPO (PCT)
Prior art keywords
methylidenyl
protein kinase
indolinone
modulators
prodrugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/017845
Other languages
French (fr)
Other versions
WO2000008202A2 (en
WO2000008202A9 (en
Inventor
Peng Cho Tang
Li Sun
Todd Anthony Miller
Congxin Liang
Ngoc My Tran
Anh Thi Nguyen
Asaad Nematalla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sugen LLC
Original Assignee
Sugen LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen LLC filed Critical Sugen LLC
Priority to AU54684/99A priority Critical patent/AU5468499A/en
Priority to CA002383623A priority patent/CA2383623A1/en
Priority to JP2000563824A priority patent/JP2002522452A/en
Priority to US09/762,198 priority patent/US6531502B1/en
Publication of WO2000008202A2 publication Critical patent/WO2000008202A2/en
Publication of WO2000008202A3 publication Critical patent/WO2000008202A3/en
Publication of WO2000008202A9 publication Critical patent/WO2000008202A9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to novel 3-methylidenyl-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
PCT/US1999/017845 1998-01-21 1999-08-04 3-methylidenyl-2-indolinone modulators of protein kinase Ceased WO2000008202A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU54684/99A AU5468499A (en) 1998-08-04 1999-08-04 3-methylidenyl-2-indolinone modulators of protein kinase
CA002383623A CA2383623A1 (en) 1998-08-04 1999-08-04 3-methylidenyl-2-indolinone modulators of protein kinase
JP2000563824A JP2002522452A (en) 1998-08-04 1999-08-04 Regulator of protein kinase 3-methylidenyl-2-indolinone
US09/762,198 US6531502B1 (en) 1998-01-21 1999-08-04 3-Methylidenyl-2-indolinone modulators of protein kinase

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US12925698A 1998-08-04 1998-08-04
US9547098P 1998-08-05 1998-08-05
US10217898P 1998-09-28 1998-09-28
US11610799P 1999-01-15 1999-01-15
US60/095,470 1999-01-15
US60/102,178 1999-01-15
US09/129,256 1999-01-15
US60/116,107 1999-01-15

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US09/762,198 A-371-Of-International US6531502B1 (en) 1998-01-21 1999-08-04 3-Methylidenyl-2-indolinone modulators of protein kinase
US09762198 A-371-Of-International 1999-08-04
US10/383,690 Division US6855730B2 (en) 1998-08-05 2003-03-10 3-methylidenyl-2-indolinone modulators of protein kinase

Publications (3)

Publication Number Publication Date
WO2000008202A2 WO2000008202A2 (en) 2000-02-17
WO2000008202A3 true WO2000008202A3 (en) 2000-05-18
WO2000008202A9 WO2000008202A9 (en) 2000-07-27

Family

ID=27492796

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/017845 Ceased WO2000008202A2 (en) 1998-01-21 1999-08-04 3-methylidenyl-2-indolinone modulators of protein kinase

Country Status (4)

Country Link
JP (1) JP2002522452A (en)
AU (1) AU5468499A (en)
CA (1) CA2383623A1 (en)
WO (1) WO2000008202A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777417B2 (en) 2001-09-10 2004-08-17 Sugen, Inc. 3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene-2-indolinone derivatives as kinase inhibitors

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6569868B2 (en) 1998-04-16 2003-05-27 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
CN1158283C (en) 1998-12-17 2004-07-21 霍夫曼-拉罗奇有限公司 4-and 5-pyrazinyl oxindoles as protein kinase inhibitors
US6153634A (en) 1998-12-17 2000-11-28 Hoffmann-La Roche Inc. 4,5-azolo-oxindoles
DE69906152T2 (en) * 1998-12-17 2004-02-12 F. Hoffmann-La Roche Ag 4-ALKENYL (AND ALKINYL) OXOINDOLE AS INHIBITORS CYCLINE-DEPENDENT KINASES, ESPECIALLY CDK2
BR9916223A (en) 1998-12-17 2001-09-04 Hoffmann La Roche 4-aryloxindols as inhibitors of jnk protein kinases
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
JP5336686B2 (en) * 1999-11-24 2013-11-06 スージェン， インク． Formulations for drugs that can be ionized as free acids or free bases
US6313310B1 (en) 1999-12-15 2001-11-06 Hoffmann-La Roche Inc. 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles
SK287142B6 (en) 2000-02-15 2010-01-07 Sugen, Inc. Pyrrole substituted 2-indolinone protein kinase inhibitors, pharmacutical composition and use
CA2407799A1 (en) 2000-05-02 2001-11-08 Sugen, Inc. (2-oxindol-3-ylidenyl)acetic acid derivatives and their use as protein kinase inhibitors
TWI270545B (en) 2000-05-24 2007-01-11 Sugen Inc Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
WO2001094312A2 (en) * 2000-06-02 2001-12-13 Sugen, Inc. Indolinone derivatives as protein kinase/phosphatase inhibitors
JP2004518669A (en) 2000-12-20 2004-06-24 スージェン・インコーポレーテッド 4-Aryl substituted indolinone
AR042586A1 (en) 2001-02-15 2005-06-29 Sugen Inc 3- (4-AMIDOPIRROL-2-ILMETILIDEN) -2-INDOLINONE AS INHIBITORS OF PROTEIN KINASE; YOUR PHARMACEUTICAL COMPOSITIONS; A METHOD FOR THE MODULATION OF THE CATALYTIC ACTIVITY OF PROTEINQUINASE; A METHOD TO TREAT OR PREVENT AN AFFECTION RELATED TO PROTEINQUINASE
WO2002070478A1 (en) 2001-03-06 2002-09-12 Astrazeneca Ab Indolone derivatives having vascular-damaging activity
US7081454B2 (en) 2001-03-28 2006-07-25 Bristol-Myers Squibb Co. Tyrosine kinase inhibitors
WO2002081466A1 (en) 2001-04-09 2002-10-17 Sugen, Inc. Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
CA2448076A1 (en) * 2001-05-24 2002-11-28 Masahiko Hayakawa 3-quinoline-2-(1h)-ylideneindolin-2-one derivatives
AR036042A1 (en) 2001-05-30 2004-08-04 Sugen Inc DERIVATIVES ARALQUILSUFONIL-3- (PIRROL-2-ILMETILIDEN) -2-INDOLINONA, ITS PHARMACEUTICAL COMPOSITIONS AND METHOD FOR THE MODULATION OF THE CATALYTIC ACTIVITY OF A KINASE PROTEIN
WO2003027111A1 (en) * 2001-09-27 2003-04-03 Smithkline Beecham Corporation Chemical compounds
WO2004048366A1 (en) * 2002-11-22 2004-06-10 Yamanouchi Pharmaceutical Co., Ltd. 2-oxoindoline derivatives
JP4879492B2 (en) * 2002-11-27 2012-02-22 アラーガン、インコーポレイテッド Kinase inhibitors for the treatment of diseases
US7517697B2 (en) * 2003-02-05 2009-04-14 Applied Biosystems, Llc Compositions and methods for preserving RNA in biological samples
US7312215B2 (en) 2003-07-29 2007-12-25 Bristol-Myers Squibb Company Benzimidazole C-2 heterocycles as kinase inhibitors
GT200500321A (en) * 2004-11-09 2006-09-04 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF PROTEIN KINASE.
US7960548B2 (en) * 2005-04-29 2011-06-14 The Ohio State University Research Foundation Keratinocyte growth factor receptor—tyrosine specific inhibitors for the prevention of cancer metastatis
WO2009030270A1 (en) * 2007-09-03 2009-03-12 Novartis Ag Dihydroindole derivatives useful in parkinson's disease
AU2008340991B2 (en) * 2007-12-21 2012-02-23 University Health Network Indazolyl, benzimidazolyl, benzotriazolyl substituted indolinone derivatives as kinase inhibitors useful in the treatment of cancer
CA2756568C (en) 2009-04-06 2018-02-13 University Health Network Kinase inhibitors and method of treating cancer with same
FR2948940B1 (en) * 2009-08-04 2011-07-22 Servier Lab NOVEL DIHYDROINDOLONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ES2639757T3 (en) 2010-04-06 2017-10-30 University Health Network Synthesis of 2- (1H-indazol-6-yl) spiro [cyclopropan-1,3'-indolin] -2'-chiral onas
WO2012048411A1 (en) * 2010-10-13 2012-04-19 University Health Network Plk-4 inhibitors and method of treating cancer with same
WO2012142029A2 (en) * 2011-04-10 2012-10-18 Florida A&M University Serms for the treatment of estrogen receptor-mediated disorders
EP2895476B1 (en) 2012-09-13 2016-06-22 F.Hoffmann-La Roche Ag 2-oxo-2,3-dihydro-indoles for the treatment of cns disorders
US9296730B2 (en) 2012-10-26 2016-03-29 Regents Of The University Of Minnesota Aurora kinase inhibitors
CN105764515B (en) 2013-10-18 2020-02-28 大学健康网络 Treatment of pancreatic cancer
MX2018005894A (en) * 2015-11-12 2018-08-15 Lg Chemical Ltd Pharmaceutical composition containing, as active ingredient, 7-azaindolin-2-one derivative or pharmaceutically acceptable salt thereof.
US10487054B2 (en) 2017-04-21 2019-11-26 Regents Of The University Of Minnesota Therapeutic compounds
WO2020070331A1 (en) * 2018-10-05 2020-04-09 Ichnos Sciences S.A. Indolinone compounds for use as map4k1 inhibitors
WO2022006412A2 (en) * 2020-07-02 2022-01-06 The Regents Of The University Of Colorado, A Body Corporate Conjugates of ampk inhibitors and protac degraders and related uses
GR1010103B (en) * 2020-07-02 2021-10-18 Uni-Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Αβεε, 3-indol-2-ylmethylidene-indolin-2-ones as autotaxin inhibitors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5339992A (en) * 1991-07-10 1994-08-23 Societe De Prospection Et D'inventions Techniques (S.P.I.T. Tubular cartridge for storing and applying a non-solid product, and a drive and thrust assembly for the cartridge
US5374652A (en) * 1990-02-28 1994-12-20 Farmitalia Carlo Erba S R L 2-oxindole compounds which are useful as tyrosine kinase inhibitors
US5382593A (en) * 1992-07-21 1995-01-17 Adir Et Compagnie New 3-(hydroxybenzylidenyl)-indolin-2-ones
US5409949A (en) * 1991-07-12 1995-04-25 Farmitalia Carlo Erba S.R.L. Methylen-oxindole derivatives compositions and tyrosine kinase inhibition therewith
US5650415A (en) * 1995-06-07 1997-07-22 Sugen, Inc. Quinoline compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374652A (en) * 1990-02-28 1994-12-20 Farmitalia Carlo Erba S R L 2-oxindole compounds which are useful as tyrosine kinase inhibitors
US5339992A (en) * 1991-07-10 1994-08-23 Societe De Prospection Et D'inventions Techniques (S.P.I.T. Tubular cartridge for storing and applying a non-solid product, and a drive and thrust assembly for the cartridge
US5409949A (en) * 1991-07-12 1995-04-25 Farmitalia Carlo Erba S.R.L. Methylen-oxindole derivatives compositions and tyrosine kinase inhibition therewith
US5382593A (en) * 1992-07-21 1995-01-17 Adir Et Compagnie New 3-(hydroxybenzylidenyl)-indolin-2-ones
US5650415A (en) * 1995-06-07 1997-07-22 Sugen, Inc. Quinoline compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777417B2 (en) 2001-09-10 2004-08-17 Sugen, Inc. 3-(4,5,6,7-tetrahydroindol-2-ylmethylidiene-2-indolinone derivatives as kinase inhibitors

Also Published As

Publication number Publication date
CA2383623A1 (en) 2000-02-17
WO2000008202A2 (en) 2000-02-17
WO2000008202A9 (en) 2000-07-27
JP2002522452A (en) 2002-07-23
AU5468499A (en) 2000-02-28

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