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WO2000001798A3 - Modele de pointe et matrice a acces selectif pour transfert micro-fluidique - Google Patents

Modele de pointe et matrice a acces selectif pour transfert micro-fluidique Download PDF

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Publication number
WO2000001798A3
WO2000001798A3 PCT/US1999/015214 US9915214W WO0001798A3 WO 2000001798 A3 WO2000001798 A3 WO 2000001798A3 US 9915214 W US9915214 W US 9915214W WO 0001798 A3 WO0001798 A3 WO 0001798A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid
tip
target
print head
transfer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/015214
Other languages
English (en)
Other versions
WO2000001798A2 (fr
Inventor
Don Rose
Thomas C Tisone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cartesian Technologies Inc
Original Assignee
Cartesian Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cartesian Technologies Inc filed Critical Cartesian Technologies Inc
Priority to EP99932267A priority Critical patent/EP1129008A4/fr
Priority to AU48610/99A priority patent/AU4861099A/en
Publication of WO2000001798A2 publication Critical patent/WO2000001798A2/fr
Publication of WO2000001798A3 publication Critical patent/WO2000001798A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1011—Control of the position or alignment of the transfer device
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0262—Drop counters; Drop formers using touch-off at substrate or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00367—Pipettes capillary
    • B01J2219/00369—Pipettes capillary in multiple or parallel arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezoelectric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00621—Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La présente invention concerne une pointe en céramique (200) et une tête d'impression à accès sélectif (230) destinées au transfert de quantités micro-fluidiques de fluide. La tête d'impression (230) peut effectuer le transfert d'échantillons depuis une plaque source (29) sur une cible (30) en recueillant et déposant les échantillons de fluide de façon sélective. La tête d'impression (230) peut également être programmée pour créer un mappage direct des échantillons de fluide de la plaque source (29) sur la cible (30) ou pour créer tout motif ou impression désirée sur la cible (30). La pointe (200) et la tête d'impression (230) peuvent être utilisées dans une large gamme d'applications telles que la formation de micro-matrices d'ADN et le reformatage de composés. Dans un mode de réalisation préféré, la pointe (200) est utilisée comme pointe capillaire ou 'de gravité' afin d'attirer ou recueillir un fluide source et de le placer ou de le déposer sur une cible (30) via un contact physique (décharge). Dans un autre mode de réalisation préféré, la pointe (200) est utilisée conjointement avec un système d'aspiration-distribution (10) qui aspire activement un fluide source et le dépose avec ou sans contact. La pointe de l'invention (200) permet d'effectuer des transferts micro-fluidiques améliorés, précis et répétés.
PCT/US1999/015214 1998-07-07 1999-07-07 Modele de pointe et matrice a acces selectif pour transfert micro-fluidique Ceased WO2000001798A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99932267A EP1129008A4 (fr) 1998-07-07 1999-07-07 Modele de pointe et matrice a acces selectif pour transfert micro-fluidique
AU48610/99A AU4861099A (en) 1998-07-07 1999-07-07 Tip design and random access array for microfluidic transfer

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US9192898P 1998-07-07 1998-07-07
US60/091,928 1998-07-07
US10671998P 1998-11-02 1998-11-02
US60/106,719 1998-11-02
US11306298P 1998-12-21 1998-12-21
US60/113,062 1998-12-21
US13846499P 1999-06-10 1999-06-10
US60/138,464 1999-06-10
US13902499P 1999-06-14 1999-06-14
US60/139,024 1999-06-14

Publications (2)

Publication Number Publication Date
WO2000001798A2 WO2000001798A2 (fr) 2000-01-13
WO2000001798A3 true WO2000001798A3 (fr) 2000-02-17

Family

ID=27536617

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/015214 Ceased WO2000001798A2 (fr) 1998-07-07 1999-07-07 Modele de pointe et matrice a acces selectif pour transfert micro-fluidique

Country Status (4)

Country Link
EP (1) EP1129008A4 (fr)
CN (1) CN1315913A (fr)
AU (1) AU4861099A (fr)
WO (1) WO2000001798A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7547556B2 (en) 1998-01-12 2009-06-16 Massachusetts Institute Of Technology Methods for filing a sample array by droplet dragging
US7604983B2 (en) 2000-02-18 2009-10-20 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US9428800B2 (en) 2002-12-20 2016-08-30 Life Technologies Corporation Thermal cycling apparatus and method

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000157272A (ja) * 1998-12-01 2000-06-13 Hitachi Software Eng Co Ltd バイオチップ及びその製造方法
AU756982B2 (en) 1999-03-19 2003-01-30 Life Technologies Corporation Multi-through hole testing plate for high throughput screening
US6589791B1 (en) 1999-05-20 2003-07-08 Cartesian Technologies, Inc. State-variable control system
GB9916406D0 (en) * 1999-07-13 1999-09-15 Biorobotics Ltd Liquid transfer pin
DE19946525A1 (de) * 1999-09-28 2001-05-03 Fraunhofer Ges Forschung Vorrichtung zur Aufnahme und Abgabe kleinster Flüssigkeitsmengen
CA2400789A1 (fr) 2000-02-22 2001-08-30 Genospectra, Inc. Techniques et dispositif de fabrication de jeux ordonnes de microechantillons
JP2004502923A (ja) 2000-02-22 2004-01-29 ジェノスペクトラ，インコーポレイティド マイクロアレイの製造方法と製造装置
US6447723B1 (en) * 2000-03-13 2002-09-10 Packard Instrument Company, Inc. Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments
US6878554B1 (en) 2000-03-20 2005-04-12 Perkinelmer Las, Inc. Method and apparatus for automatic pin detection in microarray spotting instruments
US6756232B1 (en) * 2000-03-20 2004-06-29 Perkinelmer Las, Inc. Method and apparatus for producing compact microarrays
DE10017105A1 (de) * 2000-04-06 2001-10-11 Basf Ag Verfahren und Vorrichtung zur Herstellung von Biopolymer-Feldern
US6943035B1 (en) 2000-05-19 2005-09-13 Genetix Limited Liquid dispensing apparatus and method
US7521245B1 (en) 2000-06-05 2009-04-21 Perkinelmer Las, Inc. Method for washing and drying pins in microarray spotting instruments
EP1333926B1 (fr) * 2000-11-17 2004-09-22 Tecan Trading AG Dispositif et systeme de distribution ou d'absorption/distribution d'echantillons de liquide
US6613284B2 (en) * 2001-02-01 2003-09-02 V&P Scientific, Inc. Microarrayer
WO2002063272A2 (fr) * 2001-02-06 2002-08-15 Parallel Synthesis Technologies Dispositif de depot microfabrique destine a former des jeux ordonnes de microdepots de faible cout
CH694754A5 (de) * 2001-03-15 2005-07-15 Tecan Trading Ag Pipettenspitze.
CN1385518A (zh) * 2001-04-23 2002-12-18 株式会社百尼尔 生物学试料的微细排列用点样装置及该装置中使用的点样针
US6558907B2 (en) 2001-05-16 2003-05-06 Corning Incorporated Methods and compositions for arraying nucleic acids onto a solid support
US6752182B2 (en) * 2001-06-28 2004-06-22 Genetix Limited Microarraying apparatus, pin head therefor and spotting method
JP2003043041A (ja) * 2001-08-01 2003-02-13 Canon Inc 液体吐出装置及び試料担体の製造装置
WO2003013718A1 (fr) * 2001-08-10 2003-02-20 Oxford Glycosciences (Uk) Ltd Dispositif et procede de distribution de liquides
EP1658894A1 (fr) 2002-02-22 2006-05-24 Biodot, Inc. Dispositif de dispersion de gouttelettes de reactif sous la surface d'un fluide au moyen d'une distribution sans contact
AU2003218727A1 (en) * 2002-03-11 2003-09-22 Axaron Bioscience Ag Method for applying a substance to a substrate
JP2003329680A (ja) * 2002-05-10 2003-11-19 Hitachi Software Eng Co Ltd スポットピン、スポッティング装置及び生体分子スポット方法
US8277753B2 (en) * 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
DE10255595A1 (de) 2002-11-26 2004-06-03 Cybio Ag Mehrkanaldosiervorrichtung mit automatischer Kalibrierung
WO2004067700A2 (fr) * 2003-01-31 2004-08-12 Apogent Robotics Limited Systeme de transfert de liquides
DE10316580A1 (de) * 2003-04-10 2004-11-04 Infineon Technologies Ag Vorrichtung zum beschädigungsfreien Aufbringen von Bio-Molekülen in Lösung auf empfindlichen Substraten
EP1654067A4 (fr) * 2003-07-11 2008-01-02 Genomic Solutions Inc Appareil et procedes destines a la manipulation d'echantillons liquides, utilisant l'action capillaire
US7097070B2 (en) 2003-08-15 2006-08-29 Protedyne Corporation Method and apparatus for handling small volume fluid samples
AU2005222618A1 (en) 2004-03-12 2005-09-29 Biotrove, Inc. Nanoliter array loading
US7690325B2 (en) 2004-04-30 2010-04-06 Bioforce Nanosciences, Inc. Method and apparatus for depositing material onto a surface
US7759062B2 (en) 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
US20100092683A1 (en) 2006-09-22 2010-04-15 Clondiag Gmbh Dispenser device for and a method of dispensing a substance onto a substrate
US10753927B2 (en) 2006-09-22 2020-08-25 ALERE TECHNOLOGIES GmbH Methods for detecting an analyte
JP5632316B2 (ja) * 2011-03-18 2014-11-26 株式会社日立ハイテクノロジーズ 質量分析装置及びそれに用いられるイオン源
CN104759373B (zh) * 2012-04-25 2017-08-01 艾博生物医药(杭州)有限公司 一种液体分配设备
CN103657548A (zh) * 2012-08-31 2014-03-26 艾博生物医药(杭州)有限公司 一种自动添加液体试剂的方法及设备
CN106687221B (zh) * 2014-07-25 2020-07-03 拜奥多特公司 具有纵向换能器和可置换毛细管的压电分配器
EP3197604A1 (fr) * 2014-09-23 2017-08-02 Gencell Biosystems Limited Distribution basée sur la pression
DE102016211496A1 (de) * 2016-06-27 2017-12-28 Robert Bosch Gmbh Dispensnadel und System mit solch einer Dispensnadel
EP3502650B1 (fr) * 2017-12-22 2023-07-19 Universiteit Maastricht Procédé et appareil pour appliquer un liquide sur un substrat
CN111989390B (zh) * 2018-04-16 2024-08-30 南京金斯瑞生物科技有限公司 用于从样品提取生物分子的系统及相关方法
US12270820B2 (en) 2018-06-04 2025-04-08 Hewlett-Packard Development Company, L.P. Ejection subassembly pitches to match nanowell spacing
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US20210311081A1 (en) * 2018-11-02 2021-10-07 Hewlett-Packard Development Company, L.P. Randomized dispensing order
DE112019006814T5 (de) 2019-02-01 2021-10-21 Xtpl S.A. Fluiddruckeinrichtung
US11673406B2 (en) 2019-02-01 2023-06-13 Xtpl S.A. Method of printing fluid
CN112439470B (zh) * 2019-08-30 2022-07-12 北京达微生物科技有限公司 一种制备微液滴的加样针以及微液滴的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3164304A (en) * 1961-05-08 1965-01-05 Standard Thomson Corp Liquid dispensing apparatus for small quantities
US4944922A (en) * 1986-07-04 1990-07-31 Tosoh Corporation Quantitative dispenser for a liquid
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR52270E (fr) * 1942-06-04 1943-12-01 Perfectionnements aux compte-gouttes, flacons, collyres, pipettes, etc.
GB8612261D0 (en) * 1986-05-20 1986-06-25 Boots Celltech Diagnostics Fluid dispensing apparatus
GB2310006B (en) * 1995-12-01 2000-01-12 Genetix Ltd Pneumatic actuator
US5770151A (en) * 1996-06-05 1998-06-23 Molecular Dynamics, Inc. High-speed liquid deposition device for biological molecule array formation
US5743960A (en) * 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
US5741554A (en) * 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3164304A (en) * 1961-05-08 1965-01-05 Standard Thomson Corp Liquid dispensing apparatus for small quantities
US4944922A (en) * 1986-07-04 1990-07-31 Tosoh Corporation Quantitative dispenser for a liquid
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1129008A4 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7547556B2 (en) 1998-01-12 2009-06-16 Massachusetts Institute Of Technology Methods for filing a sample array by droplet dragging
US7604983B2 (en) 2000-02-18 2009-10-20 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US8906618B2 (en) 2000-02-18 2014-12-09 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US9518299B2 (en) 2000-02-18 2016-12-13 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US9428800B2 (en) 2002-12-20 2016-08-30 Life Technologies Corporation Thermal cycling apparatus and method

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CN1315913A (zh) 2001-10-03
EP1129008A4 (fr) 2001-12-05
AU4861099A (en) 2000-01-24
EP1129008A2 (fr) 2001-09-05
WO2000001798A2 (fr) 2000-01-13

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