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WO2000078960A3 - Compositions and methods for the therapy and diagnosis of breast cancer - Google Patents

Compositions and methods for the therapy and diagnosis of breast cancer Download PDF

Info

Publication number
WO2000078960A3
WO2000078960A3 PCT/US2000/017536 US0017536W WO0078960A3 WO 2000078960 A3 WO2000078960 A3 WO 2000078960A3 US 0017536 W US0017536 W US 0017536W WO 0078960 A3 WO0078960 A3 WO 0078960A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
breast cancer
diagnosis
therapy
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/017536
Other languages
French (fr)
Other versions
WO2000078960A2 (en
WO2000078960A9 (en
Inventor
Jiang Yuqiu
Jennifer L Mitcham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corixa Corp
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU56384/00A priority Critical patent/AU5638400A/en
Application filed by Corixa Corp filed Critical Corixa Corp
Publication of WO2000078960A2 publication Critical patent/WO2000078960A2/en
Publication of WO2000078960A3 publication Critical patent/WO2000078960A3/en
Anticipated expiration legal-status Critical
Publication of WO2000078960A9 publication Critical patent/WO2000078960A9/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.
PCT/US2000/017536 1999-06-23 2000-06-23 Compositions and methods for the therapy and diagnosis of breast cancer Ceased WO2000078960A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU56384/00A AU5638400A (en) 1999-06-23 1999-08-26 Compositions and methods for the therapy and diagnosis of breast cancer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14090399P 1999-06-23 1999-06-23
US60/140,903 1999-06-23
US15898099P 1999-10-12 1999-10-12
US60/158,980 1999-10-12

Publications (3)

Publication Number Publication Date
WO2000078960A2 WO2000078960A2 (en) 2000-12-28
WO2000078960A3 true WO2000078960A3 (en) 2001-06-07
WO2000078960A9 WO2000078960A9 (en) 2002-05-02

Family

ID=26838580

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/017536 Ceased WO2000078960A2 (en) 1999-06-23 2000-06-23 Compositions and methods for the therapy and diagnosis of breast cancer

Country Status (2)

Country Link
AU (1) AU5638400A (en)
WO (1) WO2000078960A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6730477B1 (en) 1998-08-04 2004-05-04 Diadexus, Inc. Method of diagnosing, monitoring and staging breast cancer
US6737040B1 (en) 1998-08-04 2004-05-18 Diadexus, Inc. Method and antibody for imaging breast cancer
DE69939874D1 (en) 1998-09-02 2008-12-18 Diadexus Inc METHOD OF DIAGNOSIS, EVALUATION AND IMAGE DISPLAY OF VARIOUS CANCER DISORDERS
US7414112B2 (en) 1998-10-08 2008-08-19 Genentech, Inc. Antibodies to PRO1550 polypeptides
US6902892B1 (en) 1998-10-19 2005-06-07 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating prostate cancer
WO2001040269A2 (en) 1999-11-30 2001-06-07 Corixa Corporation Compositions and methods for therapy and diagnosis of breast cancer
CA2402729A1 (en) * 2000-03-15 2001-09-20 Incyte Genomics, Inc. Human immune response proteins
WO2001083781A2 (en) * 2000-04-28 2001-11-08 Millennium Pharmaceuticals, Inc. 14094, a novel human trypsin family member and uses thereof
EP2305710A3 (en) 2002-06-03 2013-05-29 Genentech, Inc. Synthetic antibody phage libraries
CN100357320C (en) * 2005-01-18 2007-12-26 北京大学 ZIBC gene and its coded protein and uses
GB0523827D0 (en) * 2005-11-23 2006-01-04 Ares Trading Sa Netrin-like (NTR) domain containing protein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999014230A1 (en) * 1997-09-18 1999-03-25 Washington University Mammaglobin, a secreted mammary-specific breast cancer protein

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999014230A1 (en) * 1997-09-18 1999-03-25 Washington University Mammaglobin, a secreted mammary-specific breast cancer protein

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANTJE BOSSE ET AL.: "Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system", MECHANISMS OF DEVELOPMENT, vol. 69, no. 1,2, December 1997 (1997-12-01), pages 169 - 181, XP000982338 *
DATABASE EMBL [online] 27 May 1999 (1999-05-27), ROBERT STRAUSBERG: "tx50f03.x1 NCI_CGAP_Lu24 Homosapiens cDNA clone", XP002160838, Database accession no. AI681917 *
DATABASE SWALL [online] 15 July 1998 (1998-07-15), XP002160839, Database accession no. P81067 *

Also Published As

Publication number Publication date
AU5638400A (en) 2001-01-09
WO2000078960A2 (en) 2000-12-28
WO2000078960A9 (en) 2002-05-02

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