WO2000073801A2

WO2000073801A2 - Breast, gastric and prostate cancer associated antigens and uses therefor

Info

Publication number: WO2000073801A2
Application number: PCT/US2000/014749
Authority: WO
Inventors: Yuichi Obata
Original assignee: Ludwig Institute for Cancer Research Ltd; Ludwig Cancer Research
Current assignee: Ludwig Institute for Cancer Research Ltd; Ludwig Cancer Research
Priority date: 1999-05-28
Filing date: 2000-05-26
Publication date: 2000-12-07
Anticipated expiration: 2001-11-28
Also published as: JP2003518364A; WO2000073801A3; EP1259812A2; AU5047800A

Abstract

Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in breast, gastric and prostate cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with cancer. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.

Description

BREAST. GASTKICaftBBrPROSTATE CANCER ASSOCIATED ANTIGENS AND USES THEREFOR

Field of the Invention The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with breast, gastric or prostate cancer. The invention also relates to agents which bind the nucleic acids or polypeptides. The nucleic acid molecules, polypeptides coded for by such molecules and peptides derived therefrom, as well as related antibodies and cytolytic T lymphocytes, are useful, inter alia, in diagnostic and therapeutic contexts.

Background of the Invention

The mechanism by which T cells recognize foreign materials has been implicated in cancer. A number of cytolytic T lymphocyte (CTL) clones directed against autologous melanoma antigens, testicular antigens, and melanocyte differentiation antigens have been described. In many instances, the antigens recognized by these clones have been characterized.

The use of autologous CTLs for identifying tumor antigens requires that the target cells which express the antigens can be cultured in vitro and that stable lines of autologous CTL clones which recognize the antigen-expressing cells can be isolated and propagated. While this approach has worked well for melanoma antigens, other tumor types, such as epithelial cancers including breast and colon cancer, have proved refractory to the approach.

More recently another approach to the problem has been described by Sahin et al. (Proc. Natl. Acad. Sci. USA 92:11810-11813, 1995). According to this approach, autologous antisera are used to identify immunogenic protein antigens expressed in cancer cells by screening expression libraries constructed from tumor cell cDNA. Antigen-encoding clones so identified have been found to elicit a high-titer humoral immune response in the patients from which the antisera were obtained. Such a high-titer IgG response implies helper T cell recognition of the detected antigen. These tumor antigens can then be screened for the presence of MHC/HLA class I and class II motifs and reactivity with CTLs.

Since the individual tumor antigens presently known may be expressed only in a fraction of tumors, the availability of additional tumor antigens would significantly enlarge the proportion of patients who are potentially eligible for therapeutic interventions. Thus there presently is a need for additional tumor antigens for development of therapeutics and diagnostics applicable to a greater number of cancer patients having various cancers. The invention is elaborated upon further in the disclosure which follows.

Summary of the Invention Autologous antibody screening has now been applied to breast, gastric and prostate cancer using antisera from cancer patients. Numerous cancer associated antigens have been identified. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and CTLs which recognize the proteins and peptides. Fragments including functional fragments and variants of the foregoing also are provided. Kits containing the foregoing molecules additionally are provided. The foregoing can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.

Prior to the present invention, only a handful of cancer associated genes had been identified in the past 20 years. The invention involves the surprising discovery of several genes, some previously known and some previously unknown, which are expressed in individuals who have cancer. These individuals all have serum antibodies against the proteins (or fragments thereof) encoded by these genes. Thus, abnormally expressed genes are recognized by the host's immune system and therefore can form a basis for diagnosis, monitoring and therapy.

The invention involves the use of a single material, a plurality of different materials and even large panels and combinations of materials. For example, a single gene, a single protein encoded by a gene, a single functional fragment thereof, a single antibody thereto, etc. can be used in methods and products of the invention. Likewise, pairs, groups and even panels of these materials and optionally other cancer associated antigen genes and/or gene products can be used for diagnosis, monitoring and therapy. The pairs, groups or panels can involve 2, 3, 4, 5 or more genes, gene products, fragments thereof or agents that recognize such materials. A plurality of such materials are not only useful in monitoring, typing, characterizing and diagnosing cells abnormally expressing such genes, but a plurality of such materials can be used therapeutically. An example of the use of a plurality of such materials for the prevention, delay of onset, amelioration, etc. of cancer cells, which express or will express such genes prophylactically or acutely. Any and all combinations of the genes, gene products, and materials which recognize the genes and gene products can be tested and identified for use according to the invention. It would be far too lengthy to recite all such combinations; those skilled in the art, particularly in view of the teaching contained herein, will readily be able to determine which combinations are most appropriate for which circumstances.

As will be clear from the following discussion, the invention has in vivo and in vitro uses, including for therapeutic, diagnostic, monitoring and research purposes. One aspect of the invention is the ability to fingerprint a cell expressing a number of the genes identified according to the invention by, for example, quantifying the expression of such gene products. Such fingerprints will be characteristic, for example, of the stage of the cancer, the type of the cancer, or even the effect in animal models of a therapy on a cancer. Cells also can be screened to determine whether such cells abnormally express the genes identified according to the invention.

The invention, in one aspect, is a method of diagnosing a disorder characterized by expression of a cancer associated antigen precursor coded for by a nucleic acid molecule. The method involves the steps of contacting a biological sample isolated from a subject with an agent that specifically binds to the nucleic acid molecule, an expression product thereof, or a fragment of an expression product thereof complexed with an MHC, preferably an HLA, molecule, wherein the nucleic acid molecule is a NA Group 1 nucleic acid molecule, and determining the interaction between the agent and the nucleic acid molecule, the expression product or fragment of the expression product as a determination of the disorder. In one embodiment the agent is selected from the group consisting of (a) a nucleic acid molecule comprising NA Group 1 nucleic acid molecules or a fragment thereof, (b) a nucleic acid molecule comprising NA Group 3 nucleic acid molecules or a fragment thereof, (c) a nucleic acid molecule comprising NA Group 5 nucleic acid molecules or a fragment thereof, (d) an antibody that binds to an expression product, or a fragment thereof, of NA group 1 nucleic acids, (e) an antibody that binds to an expression product, or a fragment thereof, of NA group 3 nucleic acids, (f) an antibody that binds to an expression product, or a fragment thereof, of NA group 5 nucleic acids, (g) and agent that binds to a complex of an MHC, preferably HLA, molecule and a fragment of an expression product of a NA Group 1 nucleic acid, (h) an agent that binds to a complex of an MHC, preferably HLA, molecule and a fragment of an expression product of a NA group 3 nucleic acid, and (i) an agent that binds to a complex of an MHC, preferably HLA, molecule and a fragment of an expression product of a NA Group 5 nucleic acid.

The disorder may be characterized by expression of a plurality of cancer associated antigen precursors. Thus the methods of diagnosis may include use of a plurality of agents, each of which is specific for a different human cancer associated antigen precursor (including at least one of the cancer associated antigen precursors disclosed herein), and wherein said plurality of agents is at least 2, at least 3, at least 4, at least S, at least 6, at least 7, at least 8, at least 9 or at least 10 such agents. Any of the diagnostic methods disclosed herein can be applied sequentially over time to permit determination of the prognosis or progression (or regression) of the disorder.

In each of the above embodiments the agent may be specific for a human cancer associated antigen precursor, including the breast, gastric and prostate cancer associated antigen precursors disclosed herein.

In another aspect the invention is a method for determining regression, progression or onset of a condition characterized by expression of abnormal levels of a protein encoded by a nucleic acid molecule that is a NA Group 1 molecule. The method involves the steps of monitoring a sample, from a subject who has or is suspected of having the condition, for a parameter selected from the group consisting of (i) the protein, (ii) a peptide derived from the protein, (iii) an antibody which selectively binds the protein or peptide, and (iv) cytolytic T cells specific for a complex of the peptide derived from the protein and an MHC molecule, as a determination of regression, progression or onset of said condition. In one embodiment the sample is a body fluid, a body effusion or a tissue.

In another embodiment the step of monitoring comprises contacting the sample with a detectable agent selected from the group consisting of (a) an antibody which selectively binds the protein of (i), or the peptide of (ii), (b) a protein or peptide which binds the antibody of (iii), and (c) a cell which presents the complex of the peptide and MHC molecule of (iv). In a preferred embodiment the antibody, the protein, the peptide or the cell is labeled with a radioactive label or an enzyme. The sample in a preferred embodiment is assayed for the peptide. Preferably samples are isolated from tissue or bodily fluids of the subject at sequential time points, and the samples are assayed as a determination of the regression, progression or onset of the condition from a first sequential time point to a second sequential time point.

According to another embodiment the nucleic acid molecule is one of the following: a NA Group 3 molecule or a NA Group 5 molecule. In yet another embodiment the protein is a plurality of proteins, the parameter is a plurality of parameters, each of the plurality of parameters being specific for a different one of the plurality of proteins.

The invention in another aspect is a pharmaceutical preparation for a human subject. The pharmaceutical preparation includes an agent which when administered to the subject enriches selectively the presence of complexes of an HLA molecule and a human cancer associated antigen, and a pharmaceutically acceptable carrier, wherein the human cancer associated antigen is a fragment of a human cancer associated antigen precursor encoded by a nucleic acid molecule which comprises a NA Group 1 molecule. In one embodiment the nucleic acid molecule is a NA Group 3 nucleic acid molecule. The agent in one embodiment comprises a plurality of agents, each of which enriches selectively in the subject complexes of an HLA molecule and a different human cancer associated antigen. Preferably the plurality is at least two, at least three, at least four or at least 5 different such agents.

In another embodiment the agent is selected from the group consisting of (1) an isolated polypeptide comprising the human cancer associated antigen, or a functional variant thereof, (2) an isolated nucleic acid operably linked to a promoter for expressing the isolated polypeptide, or functional variant thereof, (3) a host cell expressing the isolated polypeptide, or functional variant thereof, and (4) isolated complexes of the polypeptide, or functional variants thereof, and an HLA molecule. The agent may be a cell expressing an isolated polypeptide. In one embodiment the agent is a cell expressing an isolated polypeptide comprising the human cancer associated antigen or a functional variant thereof. In another embodiment the agent is a cell expressing an isolated polypeptide comprising the human cancer associated antigen or a functional variant thereof, and wherein the cell expresses an HLA molecule that binds the polypeptide. The cell can express one or both of the polypeptide and HLA molecule recombinantly. In preferred embodiments the cell is nonproliferative. In yet another embodiment the agent is at least two, at least three, at least four or at least five different polypeptides, each representing a different human cancer associated antigen or functional variant thereof.

The agent in one embodiment is a PP Group 2 polypeptide. In other embodiments the agent is a PP Group 3 polypeptide or a PP Group 4 polypeptide.

In an embodiment each of the pharmaceutical preparations described herein also includes an adjuvant.

According to another aspect the invention, a composition is provided which includes an isolated agent that binds selectively a PP Group 1 polypeptide. In separate embodiments the agent binds selectively to a polypeptide selected from the following: a PP Group 2 polypeptide, a PP Group 3 polypeptide, a PP Group 4 polypeptide, and a PP Group 5 polypeptide. In other embodiments, the agent is a plurality of different agents that bind selectively at least two, at least three, at least four, or at least five different such polypeptides. In each of the above described embodiments the agent may be an antibody.

In another aspect the invention is a composition of matter composed of a conjugate of the agent of the above-described compositions of the invention and a therapeutic or diagnostic agent. Preferably the conjugate is of the agent and a therapeutic or diagnostic that is an antineoplastic.

The invention in another aspect is a pharmaceutical composition which includes an isolated nucleic acid molecule selected from the group consisting of: (1) NA Group 1 molecules, and (2) NA Group 2 molecules, and a pharmaceutically acceptable carrier. In one embodiment the isolated nucleic acid molecule comprises a NA Group 3 or NA Group 4 molecule. In another embodiment the isolated nucleic acid molecule comprises at least two isolated nucleic acid molecules coding for two different polypeptides, each polypeptide comprising a different cancer associated antigen.

Preferably the pharmaceutical composition also includes an expression vector with a promoter operably linked to the isolated nucleic acid molecule. In another embodiment the pharmaceutical composition also includes a host cell recombinantly expressing the isolated nucleic acid molecule.

According to another aspect of the invention a pharmaceutical composition is provided. The pharmaceutical composition includes an isolated polypeptide comprising a PP Group 1 or a PP Group 2 polypeptide, and a pharmaceutically acceptable carrier. In one embodiment the isolated polypeptide comprises a PP Group 3 or a PP Group 4 polypeptide.

In another embodiment the isolated polypeptide comprises at least two different polypeptides, each comprising a different cancer associated antigen at least one of which is encoded by a NA group 1 molecule as disclosed herein. In separate embodiments the isolated polypeptides are selected from the following: breast cancer polypeptides or HLA binding fragments thereof and gastric cancer polypeptides or HLA binding fragments thereof. In an embodiment each of the pharmaceutical compositions described herein also includes an adjuvant.

Another aspect the invention is an isolated nucleic acid molecule comprising a NA Group 3 molecule. Another aspect the invention is an isolated nucleic acid molecule comprising a NA Group 4 molecule. The invention in another aspect is an isolated nucleic acid molecule selected from the group consisting of (a) a fragment of a nucleic acid selected from the group of nucleic acid molecules consisting of SEQ ID Nos: 1-593, of sufficient length to represent a sequence unique within the human genome, and identifying a nucleic acid encoding a human cancer associated antigen precursor, (b) complements of (a), provided that the fragment includes a sequence of contiguous nucleotides which is not identical to any sequence selected from the sequence group consisting of (1) sequences having the GenBank accession numbers of Table 1 and other sequences publicly available as of the filing date of this application, (2) complements of (1), and (3) fragments of (1) and (2). Preferably the unique fragments are fragments of a nucleic acid selected from the group of nucleic acid molecules consisting of SEQ ID NOs:12, 15, 34-59, 61, 62, 83-95, 186, 190-205, 297, 327-332, and 335-352.

In one embodiment the sequence of contiguous nucleotides is selected from the group consisting of: (1) at least two contiguous nucleotides nonidentical to the sequences in Table 1, (2) at least three contiguous nucleotides nonidentical to the sequences in Table 1, (3) at least four contiguous nucleotides nonidentical to the sequences in Table 1, (4) at least five contiguous nucleotides nonidentical to the sequences in Table 1, (5) at least six contiguous nucleotides nonidentical to the sequences in Table 1, or (6) at least seven contiguous nucleotides nonidentical to the sequences in Table 1.

In another embodiment the fragment has a size selected from the group consisting of at least: 8 nucleotides, 10 nucleotides, 12 nucleotides, 14 nucleotides, 16 nucleotides, 18 nucleotides, 20, nucleotides, 22 nucleotides, 24 nucleotides, 26 nucleotides, 28 nucleotides, 30 nucleotides, 50 nucleotides, 75 nucleotides, 100 nucleotides, 200 nucleotides, 1000 nucleotides and every integer length therebetween. In yet another embodiment the molecule encodes a polypeptide which, or a fragment of which, binds a human HLA receptor (e.g., class I or class H) or a human antibody.

Another aspect of the invention is an expression vector comprising an isolated nucleic acid molecule of the invention described above operably linked to a promoter. According to one aspect the invention is an expression vector comprising a nucleic acid operably linked to a promoter, wherein the nucleic acid is a NA Group 1 or Group 2 molecule. In another aspect the invention is an expression vector comprising a NA Group 1 or Group 2 molecule and a nucleic acid encoding an MHC, preferably HLA, molecule.

In yet another aspect the invention is a host cell transformed or transfected with an expression vector of the invention described above.

In another aspect the invention is a host cell transformed or transfected with an expression vector comprising an isolated nucleic acid molecule of the invention described above operably linked to a promoter, or an expression vector comprising a nucleic acid operably linked to a promoter, wherein the nucleic acid is a NA Group 1 or 2 molecule and further comprising a nucleic acid encoding HLA.

According to another aspect of the invention an isolated polypeptide encoded by the isolated nucleic acid molecules of the invention, described above, is provided. These include PP Group 1-5 polypeptides. The invention also includes a fragment of the polypeptide which is immunogenic. In one embodiment the fragment, or a portion of the fragment, binds HLA or a human antibody.

The invention includes in another aspect an isolated fragment of a human cancer associated antigen precursor which, or a portion of which, binds HLA or a human antibody, wherein the precursor is encoded by a nucleic acid molecule that is a NA Group 1 molecule. In one embodiment the fragment is part of a complex with HLA. In another embodiment the fragment is between 8 and 12 amino acids in length. In another embodiment the invention includes an isolated polypeptide comprising a fragment of the polypeptide of sufficient length to represent a sequence unique within the human genome and identifying a polypeptide that is a human cancer associated antigen precursor.

According to another aspect of the invention a kit for detecting the presence of the expression of a cancer associated antigen precursor is provided. The kit includes a pair of isolated nucleic acid molecules each of which consists essentially of a molecule selected from the group consisting of (a) a 12-32 nucleotide contiguous segment of the nucleotide sequence of any of the NA Group 1 molecules and (b) complements of (a), wherein the contiguous segments are nonoverlapping. In one embodiment the pair of isolated nucleic acid molecules is constructed and arranged to selectively amplify an isolated nucleic acid molecule that is a NA Group 3 molecule. Preferably, the pair amplifies a human NA Group 3 molecule. According to another aspect of the invention a method for treating a subject with a disorder characterized by expression of a human cancer associated antigen precursor is provided. The method includes the step of administering to the subject an amount of an agent, which enriches selectively in the subject the presence of complexes of an HLA molecule and a human cancer associated antigen, effective to ameliorate the disorder, wherein the human cancer associated antigen is a fragment of a human cancer associated antigen precursor encoded by a nucleic acid molecule selected from the group consisting of (a) a nucleic acid molecule comprising NA group 1 nucleic acid molecules, (b) a nucleic acid molecule comprising NA group 3 nucleic acid molecules, (c) a nucleic acid molecule comprising NA group 5 nucleic acid molecules. In one embodiment the disorder is characterized by expression of a plurality of human cancer associated antigen precursors and wherein the agent is a plurality of agents, each of which enriches selectively in the subject the presence of complexes of an HLA molecule and a different human cancer associated antigen. Preferably the plurality is at least 2, at least 3, at least 4, or at least 5 such agents. In another embodiment the agent is an isolated polypeptide selected from the group consisting of PP Group 1, PP Group 2, PP Group 3, PP Group 4, and PP group 5 polypeptides. In yet another embodiment the disorder is cancer.

According to another aspect the invention is a method for treating a subject having a condition characterized by expression of a cancer associated antigen precursor in cells of the subject. The method includes the steps of (i) removing an immunoreactive cell containing sample from the subject, (ii) contacting the immunoreactive cell containing sample to the host cell under conditions favoring production of cytolytic T cells against a human cancer associated antigen which is a fragment of the precursor, (iii) introducing the cytolytic T cells to the subject in an amount effective to lyse cells which express the human cancer associated antigen, wherein the host cell is transformed or transfected with an expression vector comprising an isolated nucleic acid molecule operably linked to a promoter, the isolated nucleic acid molecule being selected from the group of nucleic acid molecules consisting of NA Group 1, NA Group 2, NA Group 3, NA Group 4, NA Group 5.

In one embodiment the host cell recombinantly expresses an HLA molecule which binds the human cancer associated antigen. In another embodiment the host cell endogenously expresses an HLA molecule which binds the human cancer associated antigen. The invention includes in another aspect a method for treating a subject having a condition characterized by expression of a cancer associated antigen precursor in cells of the subject. The method includes the steps of (i) identifying a nucleic acid molecule expressed by the cells associated with said condition, wherein said nucleic acid molecule is a NA Group 1 molecule (ii) transfecting a host cell with a nucleic acid molecule selected from the group consisting of (a) the nucleic acid molecule identified, (b) a fragment of the nucleic acid molecule identified which includes a segment coding for a cancer associated antigen, (c) deletions, substitutions or additions to (a) or (b), and (d) degenerates of (a), (b), or (c); (iii) culturing said transfected host cells to express the transfected nucleic acid molecule, and; (iv) introducing an amount of said host cells or an extract thereof to the subject effective to increase an immune response against the cells of the subject associated with the condition. Preferably, the antigen is a human antigen and the subject is a human.

In one embodiment the method also includes the step of (a) identifying an MHC molecule which presents a portion of an expression product of the nucleic acid molecule, wherein the host cell expresses the same MHC molecule as identified in (a) and wherein the host cell presents an MHC binding portion of the expression product of the nucleic acid molecule.

In another embodiment the method also includes the step of treating the host cells to render them non-proliferative.

In yet another embodiment the immune response comprises a B-cell response or a T cell response. Preferably the response is a T-cell response which comprises generation of cytolytic T-cells specific for the host cells presenting the portion of the expression product of the nucleic acid molecule or cells of the subject expressing the human cancer associated antigen.

In another embodiment the nucleic acid molecule is a NA Group 3 molecule. Another aspect of the invention is a method for treating or diagnosing or monitoring a subject having a condition characterized by expression of an abnormal amount of a protein encoded by a nucleic acid molecule that is a NA Group 1 molecule. The method includes the step of administering to the subject an antibody which specifically binds to the protein or a peptide derived therefrom, the antibody being coupled to a therapeutically useful agent, in an amount effective to treat the condition.

In one embodiment the antibody is a monoclonal antibody. Preferably the monoclonal antibody is a chimeric antibody or a humanized antibody.

In another aspect the invention is a method for treating a condition characterized by expression in a subject of abnormal amounts of a protein encoded by a nucleic acid molecule that is a NA Group 1 nucleic acid molecule. The method involves the step of administering to a subject at least one of the pharmaceutical compositions of the invention described above in an amount effective to prevent, delay the onset of, or inhibit the condition in the subject. In one embodiment the condition is cancer. In another embodiment the method includes the step of first identifying that the subject expresses in a tissue abnormal amounts of the protein.

The invention in another aspect is a method for treating a subject having a condition characterized by expression of abnormal amounts of a protein encoded by a nucleic acid molecule that is a NA Group 1 nucleic acid molecule. The method includes the steps of (i) identifying cells from the subject which express abnormal amounts of the protein; (ii) isolating a sample of the cells; (iii) cultivating the cells, and (iv) introducing the cells to the subject in an amount effective to provoke an immune response against the cells.

In one embodiment the method includes the step of rendering the cells non- proliferative, prior to introducing them to the subject.

In another aspect the invention is a method for treating a pathological cell condition characterized by abnormal expression of a protein encoded by a nucleic acid molecule that is a NA Group 1 nucleic acid molecule. The method includes the step of administering to a subject in need thereof an effective amount of an agent which inhibits the expression or activity of the protein.

In one embodiment the agent is an inhibiting antibody which selectively binds to the protein and wherein the antibody is a monoclonal antibody, a chimeric antibody, a humanized antibody or a fragment thereof. In another embodiment the agent is an antisense nucleic acid molecule which selectively binds to the nucleic acid molecule which encodes the protein. In yet another important embodiment the nucleic acid molecule is a NA Group 3 nucleic acid molecule.

The invention includes in another aspect a composition of matter useful in stimulating an immune response to a plurality of proteins encoded by nucleic acid molecules that are NA Group 1 molecules. The composition is a plurality of peptides derived from the amino acid sequences of the proteins, wherein the peptides bind to one or more MHC molecules presented on the surface of the cells which express an abnormal amount of the protein. In one embodiment at least a portion of the plurality of peptides bind to MHC molecules and elicit a cytolytic response thereto. In another embodiment the composition of matter includes an adjuvant. In another embodiment the adjuvant is a saponin, GM-CSF, or an interleukin. In still another embodiment, the compositions also includes at least one peptide useful in stimulating an immune response to at least one protein which is not encoded by nucleic acid molecules that are NA Group 1 molecules, wherein the at least one peptide binds to one or more MHC molecules.

According to another aspect the invention is an isolated antibody which selectively binds to a complex of: (i) a peptide derived from a protein encoded by a nucleic acid molecule that is a NA Group 1 molecule and (ii) and an MHC molecule to which binds the peptide to form the complex, wherein the isolated antibody does not bind to (i) or (ii) alone.

In one embodiment the antibody is a monoclonal antibody, a chimeric antibody, a humanized antibody or a fragment thereof.

The invention also involves the use of the genes, gene products, fragments thereof, agents which bind thereto, and so on in the preparation of medicaments. A particular medicament is for treating cancers including, e.g., one or more of cancers of the breast, cervix, ovary, prostate, testis, lung, colon, pancreas, stomach, liver, skin (e.g., melanoma), bladder, head and neck, thyroid, blood cells, bone and kidney. Diagnostics for specific cancers and groups of cancers also are envisioned.

In certain preferred embodimenst, the nucleic acid molecules are selected from the group consisting of SEQ ID NOs:l-18, and the polypeptides are encoded by these preferred nucleic acid molecules.

Still other embodiments and aspects of the invention will become apparent in connection with the description of the invention which follows.

Detailed Description of the Invention

In the above summary and in the ensuing description, lists of sequences are provided. The lists are meant to embrace each single sequence separately, two or more sequences together where they form a part of the same gene, any combination of two or more sequences which relate to different genes, including and up to the total number on the list, as if each and every combination were separately and specifically enumerated. Likewise, when mentioning fragment size, it is intended that a range embrace the smallest fragment mentioned to the full- length of the sequence (less one nucleotide or amino acid so that it is a fragment), each and every fragment length intended as if specifically enumerated. Thus, if a fragment could be between 10 and 15 in length, it is explicitly meant to mean 10, 11, 12, 13, 14, or 15 in length. The summary and the claims mention antigen precursors and antigens. As used in the summary and in the claims, a precursor is substantially the full-length protein encoded by the coding region of the isolated DNA and the antigen is a peptide which complexes with MHC, preferably HLA, and which participates in the immune response as part of that complex. Such antigens are typically 9 amino acids long, although this may vary slightly.

As used herein, a subject is a human, non-human primate, cow, horse, pig, sheep, goat, dog, cat or rodent. In all embodiments human cancer antigens and human subjects are preferred.

The present invention in one aspect involves the cloning of cDNAs encoding human cancer associated antigen precursors using autologous antisera of subjects having breast, gastric or prostate cancer. The sequences of the clones representing genes identified according to the methods described herein are presented in the attached Sequence Listing. Of the foregoing, it can be seen that some of the clones are considered completely novel as no coding regions were found in the databases searched. Other clones are novel but have some nucleotide or amino acid homologies to sequences deposited in databases (mainly EST sequences). Nevertheless, the entire gene sequence was not previously known. In some cases no function was suspected and in other cases, even if a function was suspected, it was not known that the gene was associated with cancer, or with a particular cancer. In all cases, it was not known or suspected that the gene encoded a cancer antigen which reacted with an antibody from autologous sera. Analysis of the clone sequences by comparison to nucleic acid and protein databases determined that still other of the clones surprisingly are closely related to other previously-cloned genes. The sequences of these related genes is also presented in the Sequence Listing. The nature of the foregoing genes as encoding antigens recognized by the immune systems of cancer patients is, of course, unexpected.

The invention thus involves in one aspect cancer associated antigen polypeptides, genes encoding those polypeptides, functional modifications and variants of the foregoing, useful fragments of the foregoing, as well as diagnostics and therapeutics relating thereto.

Homologs and alleles of the cancer associated antigen nucleic acids of the invention can be identified by conventional techniques. Thus, an aspect of the invention is those nucleic acid sequences which code for cancer associated antigen precursors. Because this application contains so many sequences, the following chart is provided to identify the various groups of sequences discussed in the claims and in the summary:

Nucleic Acid Sequences NA Group 1. (a) nucleic acid molecules which hybridize under stringent conditions to a molecule consisting of a nucleic acid sequence selected from the group consisting of nucleic acid sequences among SEQ ID NOs: 1-593, and which code for a cancer associated antigen precursor,

(b) deletions, additions and substitutions which code for a respective cancer associated antigen precursor,

(c) nucleic acid molecules that differ from the nucleic acid molecules of (a) or (b) in codon sequence due to the degeneracy of the genetic code, and

(d) complements of (a), (b) or (c).

NA Group 2. Fragments of NA Group 1, which code for a polypeptide which, or a portion of which, binds an MHC molecule to form a complex recognized by an autologous antibody or lymphocyte.

NA Group 3. The subset of NA Group 1 where the nucleotide sequence is selected from the group consisting of:

(a) previously unknown human nucleic acids coding for a human cancer associated antigen precursor, e.g., SEQ ID NOs:12, 15, 34-59, 61, 62, 83-95, 186, 190-205, 297, 327-332, and 335-352,

(b) deletions, additions and substitutions which code for a respective human cancer associated antigen precursor,

(c) nucleic acid molecules that differ from the nucleic acid molecules of (a) or (b) in codon sequence due to the degeneracy of the genetic code, and (d) complements of (a), (b) or (c).

NA Group 4. Fragments of NA Group 3, which code for a polypeptide which, or a portion of which, binds to an MHC molecule to form a complex recognized by an autologous antibody or lymphocyte.

NA Group 5. A subset of NA Group 1, comprising human cancer associated antigens that react with allogeneic cancer antisera.

Polypeptide Sequences

PP Group 1. Polypeptides encoded by NA Group 1.

PP Group 2. Polypeptides encoded by NA Group 2.

PP Group 3. Polypeptides encoded by NA Group 3.

PP Group 4. Polypeptides encoded by NA Group 4. PP Group 5. Polypeptides encoded by NA Group 5.

Particularly preferred polypeptides are those recognized by allogeneic sera of cancer patients, but not by non-cancer patient control sera. For example, as shown in the Examples below, polypeptides encoded by SEQ ID NOs:l-18 are recognized only by antibodies in cancer patients antisera.

The term "stringent conditions" as used herein refers to parameters with which the art is familiar. Nucleic acid hybridization parameters may be found in references which compile such methods, e.g. Molecular Cloning: A Laboratory Manual, J. Sambrook, et al., eds., Second Edition, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1989, or Current Protocols in Molecular Biology, F.M. Ausubel, et al., eds., John Wiley & Sons, Inc., New York. More specifically, stringent conditions, as used herein, refers, for example, to hybridization at 65°C in hybridization buffer (3.5 x SSC, 0.02% Ficoll, 0.02% polyvinyl pyrrolidone, 0.02% Bovine Serum Albumin, 2.5 mM NaH₂PO₄(pH7), 0.5% SDS, 2 mM EDTA). SSC is 0.15 M sodium chloride/0.15 M sodium citrate, pH7; SDS is sodium dodecyl sulphate; and EDTA is ethylenediaminetetracetic acid. After hybridization, the membrane upon which the DNA is transferred is washed, for example, in 2 x SSC at room temperature and then at 0.1 - 0.5 x SSC/0.1 x SDS at temperatures up to 68°C. There are other conditions, reagents, and so forth which can be used, which result in a similar degree of stringency. The skilled artisan will be familiar with such conditions, and thus they are not given here. It will be understood, however, that the skilled artisan will be able to manipulate the conditions in a manner to permit the clear identification of homologs and alleles of cancer associated antigen nucleic acids of the invention (e.g., by using lower stringency conditions). The skilled artisan also is familiar with the methodology for screening cells and libraries for expression of such molecules which then are routinely isolated, followed by isolation of the pertinent nucleic acid molecule and sequencing.

In general homologs and alleles typically will share at least 80% nucleotide identity and/or at least 90% amino acid identity to the sequences of cancer associated antigen nucleic acid and polypeptides, respectively, in some instances will share at least 90% nucleotide identity and/or at least 95% amino acid identity and in still other instances will share at least 95% nucleotide identity and/or at least 99% amino acid identity. The homology can be calculated using various, publicly available software tools developed by NCBI (Bethesda, Maryland) that can be obtained through the Internet (ftp:/ncbi.nlm.nih.gov/pub/). Exemplary tools include the BLAST system available at http://www.ncbi.nlm.nih.gov, preferably using default settings. Pairwise and ClustalW alignments (BLOSUM30 matrix setting) as well as Kyle-Doolittle hydropathic analysis can be obtained using the Mac Vector sequence analysis software (Oxford Molecular Group). Watson-Crick complements of the foregoing nucleic acids also are embraced by the invention.

In screening for cancer associated antigen genes, a Southern blot may be performed using the foregoing conditions, together with a radioactive probe. After washing the membrane to which the DNA is finally transferred, the membrane can be placed against X-ray film to detect the radioactive signal. In screening for the expression of cancer associated antigen nucleic acids, Northern blot hybridizations using the foregoing conditions can be performed on samples taken from breast, gastric or prostate cancer patients or subjects suspected of having a condition characterized by expression of the cancer associated antigen genes disclosed herein. Amplification protocols such as polymerase chain reaction using primers which hybridize to the sequences presented also can be used for detection of the cancer associated antigen genes or expression thereof.

The breast, gastric and prostate cancer associated genes correspond to SEQ ID Nos:l- 593. These sequences represent genes previously known in humans and genes previously unknown in humans (e.g., SEQ ID NOs:12, 15, 34-59, 61, 62, 83-95, 186, 190-205, 297, 327- 332, and 335-352). Preferred breast, gastric and prostate cancer associated antigens for the methods of diagnosis disclosed herein are those which encode polypeptides that react with allogeneic cancer antisera (i.e. NA Group 5). Encoded polypeptides (e.g., proteins), peptides and antisera thereto are also preferred for diagnosis.

As used herein with respect to nucleic acids, the term "isolated" means: (i) amplified in vitro by, for example, polymerase chain reaction (PCR); (ii) recombinantly produced by cloning; (iii) purified, as by cleavage and gel separation; or (iv) synthesized by, for example, chemical synthesis. An isolated nucleic acid is one which is readily manipulable by recombinant DNA techniques well known in the art. Thus, a nucleotide sequence contained in a vector in which 5' and 3' restriction sites are known or for which polymerase chain reaction (PCR) primer sequences have been disclosed is considered isolated but a nucleic acid sequence existing in its native state in its natural host is not. An isolated nucleic acid may be substantially purified, but need not be. For example, a nucleic acid that is isolated within a cloning or expression vector is not pure in that it may comprise only a tiny percentage of the material in the cell in which it resides. Such a nucleic acid is isolated, however, as the term is used herein because it is readily manipulable by standard techniques known to those of ordinary skill in the art. An isolated nucleic acid as used herein is not a naturally occurring chromosome. As used herein with respect to polypeptides, "isolated" means separated from its native environment and present in sufficient quantity to permit its identification or use. Isolated, when referring to a protein or polypeptide, means, for example: (i) selectively produced by expression cloning or (ii) purified as by chromatography or electrophoresis. Isolated proteins or polypeptides may be, but need not be, substantially pure. The term "substantially pure" means that the proteins or polypeptides are essentially free of other substances with which they may be found in nature or in vivo systems to an extent practical and appropriate for their intended use. Substantially pure polypeptides may be produced by techniques well known in the art. Because an isolated protein may be admixed with a pharmaceutically acceptable carrier in a pharmaceutical preparation, the protein may comprise only a small percentage by weight of the preparation. The protein is nonetheless isolated in that it has been separated from the substances with which it may be associated in living systems, i.e. isolated from other proteins. The invention also includes degenerate nucleic acids which include alternative codons to those present in the native materials. For example, serine residues are encoded by the codons TCA, AGT, TCC, TCG, TCT and AGC. Each of the six codons is equivalent for the purposes of encoding a serine residue. Thus, it will be apparent to one of ordinary skill in the art that any of the serine-encoding nucleotide triplets may be employed to direct the protein synthesis apparatus, in vitro or in vivo, to incorporate a serine residue into an elongating cancer associated antigen polypeptide. Similarly, nucleotide sequence triplets which encode other amino acid residues include, but are not limited to: CCA, CCC, CCG and CCT (proline codons); CGA, CGC, CGG, CGT, AGA and AGG (arginine codons); ACA, ACC, ACG and ACT (threonine codons); AAC and AAT (asparagine codons); and ATA, ATC and ATT (isoleucine codons). Other amino acid residues may be encoded similarly by multiple nucleotide sequences. Thus, the invention embraces degenerate nucleic acids that differ from the biologically isolated nucleic acids in codon sequence due to the degeneracy of the genetic code. The invention also provides modified nucleic acid molecules which include additions, substitutions and deletions of one or more nucleotides. In preferred embodiments, these modified nucleic acid molecules and/or the polypeptides they encode retain at least one activity or function of the unmodified nucleic acid molecule and/or the polypeptides, such as antigenicity, enzymatic activity, receptor binding, formation of complexes by binding of peptides by MHC class I and class II molecules, etc. In certain embodiments, the modified nucleic acid molecules encode modified polypeptides, preferably polypeptides having conservative amino acid substitutions as are described elsewhere herein. The modified nucleic acid molecules are structurally related to the unmodified nucleic acid molecules and in preferred embodiments are sufficiently structurally related to the unmodified nucleic acid molecules so that the modified and unmodified nucleic acid molecules hybridize under stringent conditions known to one of skill in the art.

For example, modified nucleic acid molecules which encode polypeptides having single amino acid changes can be prepared. Each of these nucleic acid molecules can have one, two or three nucleotide substitutions exclusive of nucleotide changes corresponding to the degeneracy of the genetic code as described herein. Likewise, modified nucleic acid molecules which encode polypeptides having two amino acid changes can be prepared which have, e.g., 2-6 nucleotide changes. Numerous modified nucleic acid molecules like these will be readily envisioned by one of skill in the art, including for example, substitutions of nucleotides in codons encoding amino acids 2 and 3, 2 and 4, 2 and 5, 2 and 6, and so on. In the foregoing example, each combination of two amino acids is included in the set of modified nucleic acid molecules, as well as all nucleotide substitutions which code for the amino acid substitutions. Additional nucleic acid molecules that encode polypeptides having additional substitutions (i.e., 3 or more), additions or deletions (e.g., by introduction of a stop codon or a splice site(s)) also can be prepared and are embraced by the invention as readily envisioned by one of ordinary skill in the art. Any of the foregoing nucleic acids or polypeptides can be tested by routine experimentation for retention of structural relation or activity to the nucleic acids and/or polypeptides disclosed herein.

The invention also provides isolated unique fragments of cancer associated antigen nucleic acid sequences or complements thereof. A unique fragment is one that is a 'signature' for the larger nucleic acid. It, for example, is long enough to assure that its precise sequence is not found in molecules within the human genome outside of the cancer associated antigen nucleic acids defined above (and human alleles). Those of ordinary skill in the art may apply no more than routine procedures to determine if a fragment is unique within the human genome. Unique fragments, however, exclude fragments completely composed of the nucleotide sequences of any of the GenBank accession numbers listed in Table 1 or other previously published sequences as of the filing date of the priority documents for sequences listed in a respective priority document or the filing date of this application for sequences listed for the first time in this application which overlap the sequences of the invention.

A fragment which is completely composed of the sequence described in the foregoing GenBank deposits is one which does not include any of the nucleotides unique to the sequences of the invention. Thus, a unique fragment must contain a nucleotide sequence other than the exact sequence of those in GenBank or fragments thereof. The difference may be an addition, deletion or substitution with respect to the GenBank sequence or it may be a sequence wholly separate from the GenBank sequence.

Unique fragments can be used as probes in Southern and Northern blot assays to identify such nucleic acids, or can be used in amplification assays such as those employing PCR. As known to those skilled in the art, large probes such as 200, 250, 300 or more nucleotides are preferred for certain uses such as Southern and Northern blots, while smaller fragments will be preferred for uses such as PCR. Unique fragments also can be used to produce fusion proteins for generating antibodies or determining binding of the polypeptide fragments, or for generating immunoassay components. Likewise, unique fragments can be employed to produce nonfused fragments of the cancer associated antigen polypeptides, useful, for example, in the preparation of antibodies, and in immunoassays. Unique fragments further can be used as antisense molecules to inhibit the expression of cancer associated antigen nucleic acids and polypeptides, particularly for therapeutic purposes as described in greater detail below. Unique fragments also can be used to create chimeric nucleic acid molecule or polypeptide molecules by, for example, joining all or part of the unique fragment to another nucleic acid or polypeptide molecule (homologous or not). For example, the unique fragment may be similar or identical in large part to a known molecule but may have a portion which is nonidentical to the known molecule; the known molecule and the unique fragment can be used to construct a molecule containing in large part the known molecule with the portion unique to the unique fragment added. Other chimeric molecules will be known to one of ordinary skill in the art and can be prepared using standard molecular biology techniques.

As will be recognized by those skilled in the art, the size of the unique fragment will depend upon its conservancy in the genetic code. Thus, some regions of cancer associated antigen sequences and complements thereof will require longer segments to be unique while others will require only short segments, typically between 12 and 32 nucleotides (e.g. 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31 and 32 or more bases long), up to the entire length of the disclosed sequence. As mentioned above, this disclosure intends to embrace each and every fragment of each sequence, beginning at the first nucleotide, the second nucleotide and so on, up to 8 nucleotides short of the end, and ending anywhere from nucleotide number 8, 9, 10 and so on for each sequence, up to the very last nucleotide (provided the sequence is unique as described above).

Virtually any segment of the polypeptide coding region of novel cancer associated antigen nucleic acids, or complements thereof, that is 25 or more nucleotides in length will be unique. Those skilled in the art are well versed in methods for selecting such sequences, typically on the basis of the ability of the unique fragment to selectively distinguish the sequence of interest from other sequences in the human genome of the fragment to those on known databases typically is all that is necessary, although in vitro confirmatory hybridization and sequencing analysis may be performed. Especially preferred include nucleic acids encoding a series of epitopes, known as "polytopes". The epitopes can be arranged in sequential or overlapping fashion (see, e.g., Thomson et al., Proc. Natl. Acad. Sci. USA 92:5845-5849, 1995; Gilbert et al., Nature Biotechnol. 15:1280-1284, 1997), with or without the natural flanking sequences, and can be separated by unrelated linker sequences if desired. The polytope is processed to generate individual epitopes which are recognized by the immune system for generation of immune responses.

Thus, for example, peptides derived from a polypeptide having an amino acid sequence encoded by one of the nucleic acid disclosed herein, and which are presented by MHC molecules and recognized by CTL or T helper lymphocytes, can be combined with peptides from one or more other cancer associated antigens (e.g. by preparation of hybrid nucleic acids or polypeptides) to form "polytopes". The two or more peptides (or nucleic acids encoding the peptides) can be selected from those described herein, or they can include one or more peptides of previously known cancer associated antigens. Exemplary cancer associated peptide antigens that can be administered to induce or enhance an immune response are derived from tumor associated genes and encoded proteins including MAGE-A1, MAGE-A2, MAGE-A3, MAGE-A4, MAGE-A5, MAGE-A6, MAGE-A7, MAGE-A8, MAGE-A9, MAGE-A10, MAGE-A11, MAGE-A12, GAGE-1, GAGE-2, GAGE-3, GAGE-4, GAGE-5, GAGE-6, GAGE-7, GAGE-8, GAGE-9, BAGE-1, RAGE-1, LB33/MUM-1, PRAME, NAG, MAGE-B2, MAGE-B3, MAGE-B4, tyrosinase, brain glycogen phosphorylase, Melan-A, MAGE-C1, MAGE-C2, MAGE-C3, MAGE-C4, MAGE-C5, NY- ESO-1, LAGE-1, SSX-1, SSX-2 (HOM-MEL-40), SSX-4, SSX-5, SCP-1 and CT-7. See, for example, PCT application publication no. WO96/10577. Other examples will be known to one of ordinary skill in the art (for example, see Coulie, Stem Cells 13:393-403, 1995), and can be used in the invention in a like manner as those disclosed herein. One of ordinary skill in the art can prepare polypeptides comprising one or more peptides and one or more of the foregoing cancer associated peptides, or nucleic acids encoding such polypeptides, according to standard procedures of molecular biology.

Thus polytopes are groups of two or more potentially immunogenic or immune response stimulating peptides which can be joined together in various arrangements (e.g. concatenated, overlapping). The polytope (or nucleic acid encoding the polytope) can be administered in a standard immunization protocol, e.g. to animals, to test the effectiveness of the polytope in stimulating, enhancing and/or provoking an immune response.

The peptides can be joined together directly or via the use of flanking sequences to form polytopes, and the use of polytopes as vaccines is well known in the art (see, e.g., Thomson et al., Proc. Acad. Natl. Acad. Sci USA 92(13):5845-5849, 1995; Gilbert et al., Nature Biotechnol. 15(12):1280-1284, 1997; Thomson et al., J. Immunol. 157(2): 822-826, 1996; Tarn et al., J. Exp. Med. 171(l):299-306, 1990). For example, Tarn showed that polytopes consisting of both MHC class I and class II binding epitopes successfully generated antibody and protective immunity in a mouse model. Tarn also demonstrated that polytopes comprising "strings" of epitopes are processed to yield individual epitopes which are presented by MHC molecules and recognized by CTLs. Thus polytopes containing various numbers and combinations of epitopes can be prepared and tested for recognition by CTLs and for efficacy in increasing an immune response.

It is known that tumors express a set of tumor antigens, of which only certain subsets may be expressed in the tumor of any given patient. Polytopes can be prepared which correspond to the different combination of epitopes representing the subset of tumor rejection antigens expressed in a particular patient. Polytopes also can be prepared to reflect a broader spectrum of tumor rejection antigens known to be expressed by a tumor type. Polytopes can be introduced to a patient in need of such treatment as polypeptide structures, or via the use of nucleic acid delivery systems known in the art (see, e.g., Allsopp et al., Eur. J. Immunol. 26(8):1951-1959, 1996). Adenovirus, pox virus, Ty-virus like particles, adeno-associated virus, plasmids, bacteria, etc. can be used in such delivery. One can test the polytope delivery systems in mouse models to determine efficacy of the delivery system. The systems also can be tested in human clinical trials.

In instances in which a human HLA class I molecule presents tumor rejection antigens derived from cancer associated nucleic acids, the expression vector may also include a nucleic acid sequence coding for the HLA molecule that presents any particular tumor rejection antigen derived from these nucleic acids and polypeptides. Alternatively, the nucleic acid sequence coding for such a HLA molecule can be contained within a separate expression vector. In a situation where the vector contains both coding sequences, the single vector can be used to transfect a cell which does not normally express either one. Where the coding sequences for a cancer associated antigen precursor and the HLA molecule which presents it are contained on separate expression vectors, the expression vectors can be cotransfected. The cancer associated antigen precursor coding sequence may be used alone, when, e.g. the host cell already expresses a HLA molecule which presents a cancer associated antigen derived from precursor molecules. Of course, there is no limit on the particular host cell which can be used. As the vectors which contain the two coding sequences may be used in any antigen-presenting cells if desired, and the gene for cancer associated antigen precursor can be used in host cells which do not express a HLA molecule which presents a cancer associated antigen. Further, cell-free transcription systems may be used in lieu of cells.

As mentioned above, the invention embraces antisense oligonucleotides that selectively bind to a nucleic acid molecule encoding a cancer associated antigen polypeptide, to reduce the expression of cancer associated antigens. This is desirable in virtually any medical condition wherein a reduction of expression of cancer associated antigens is desirable, e.g., in the treatment of cancer. This is also useful for in vitro or in vivo testing of the effects of a reduction of expression of one or more cancer associated antigens.

As used herein, the term "antisense oligonucleotide" or "antisense" describes an oligonucleotide that is an oligoribonucleotide, oligodeoxyribonucleotide, modified oligoribonucleotide, or modified oligodeoxyribonucleotide which hybridizes under physiological conditions to DNA comprising a particular gene or to an mRNA transcript of that gene and, thereby, inhibits the transcription of that gene and/or the translation of that mRNA. The antisense molecules are designed so as to interfere with transcription or translation of a target gene upon hybridization with the target gene or transcript. Those skilled in the art will recognize that the exact length of the antisense oligonucleotide and its degree of complementarity with its target will depend upon the specific target selected, including the sequence of the target and the particular bases which comprise that sequence. It is preferred that the antisense oligonucleotide be constructed and arranged so as to bind selectively with the target under physiological conditions, i.e., to hybridize substantially more to the target sequence than to any other sequence in the target cell under physiological conditions. Based upon the sequences of nucleic acids encoding breast, gastric or prostate cancer associated antigens, or upon allelic or homologous genomic and/or cDNA sequences, one of skill in the art can easily choose and synthesize any of a number of appropriate antisense molecules for use in accordance with the present invention. For example, a "gene walk" comprising a series of oligonucleotides of 15-30 nucleotides spanning the length of a cancer associated antigen can be prepared, followed by testing for inhibition of cancer associated antigen expression. Optionally, gaps of 5-10 nucleotides can be left between the oligonucleotides to reduce the number of oligonucleotides synthesized and tested.

In order to be sufficiently selective and potent for inhibition, such antisense oligonucleotides should comprise at least 10 and, more preferably, at least 15 consecutive bases which are complementary to the target, although in certain cases modified oligonucleotides as short as 7 bases in length have been used successfully as antisense oligonucleotides (Wagner et al., Nature Biotechnol. 14:840-844, 1996). Most preferably, the antisense oligonucleotides comprise a complementary sequence of 20-30 bases. Although oligonucleotides may be chosen which are antisense to any region of the gene or mRNA transcripts, in preferred embodiments the antisense oligonucleotides correspond to N-terminal or 5' upstream sites such as translation initiation, transcription initiation or promoter sites. In addition, 3'-untranslated regions may be targeted. Targeting to mRNA splicing sites has also been used in the art but may be less preferred if alternative mRNA splicing occurs. In addition, the antisense is targeted, preferably, to sites in which mRNA secondary structure is not expected (see, e.g., Sainio et al., CellMol. Neurobiol. 14(5):439-457, 1994) and at which proteins are not expected to bind. Finally, although the listed sequences are cDNA sequences, one of ordinary skill in the art may easily derive the genomic DNA corresponding to the cDNA of a cancer associated antigen. Thus, the present invention also provides for antisense oligonucleotides which are complementary to the genomic DNA corresponding to nucleic acids encoding cancer associated antigens. Similarly, antisense to allelic or homologous cDNAs and genomic DNAs are enabled without undue experimentation.

In one set of embodiments, the antisense oligonucleotides of the invention may be composed of "natural" deoxyribonucleotides, ribonucleotides, or any combination thereof. That is, the 5' end of one native nucleotide and the 3' end of another native nucleotide may be covalently linked, as in natural systems, via a phosphodiester internucleoside linkage. These oligonucleotides may be prepared by art recognized methods which may be carried out manually or by an automated synthesizer. They also may be produced recombinantly by vectors.

In preferred embodiments, however, the antisense oligonucleotides of the invention also may include "modified" oligonucleotides. That is, the oligonucleotides may be modified in a number of ways which do not prevent them from hybridizing to their target but which enhance their stability or targeting or which otherwise enhance their therapeutic effectiveness. The term "modified oligonucleotide" as used herein describes an oligonucleotide in which (1) at least two of its nucleotides are covalently linked via a synthetic internucleoside linkage (i.e., a linkage other than a phosphodiester linkage between the 5' end of one nucleotide and the 3' end of another nucleotide) and/or (2) a chemical group not normally associated with nucleic acids has been covalently attached to the oligonucleotide. Preferred synthetic internucleoside linkages are phosphorothioates, alkylphosphonates, phosphorodithioates, phosphate esters, alkylphosphonothioates, phosphoramidates, carbamates, carbonates, phosphate triesters, acetamidates, carboxymethyl esters and peptides. The term "modified oligonucleotide" also encompasses oligonucleotides with a covalently modified base and/or sugar. For example, modified oligonucleotides include oligonucleotides having backbone sugars which are covalently attached to low molecular weight organic groups other than a hydroxyl group at the 3' position and other than a phosphate group at the 5¹ position. Thus modified oligonucleotides may include a 2'-O- alkylated ribose group. In addition, modified oligonucleotides may include sugars such as arabinose instead of ribose. The present invention, thus, contemplates pharmaceutical preparations containing modified antisense molecules that are complementary to and hybridizable with, under physiological conditions, nucleic acids encoding breast, gastric or prostate cancer associated antigen polypeptides, together with pharmaceutically acceptable carriers.

Antisense oligonucleotides may be administered as part of a pharmaceutical composition. Such a pharmaceutical composition may include the antisense oligonucleotides in combination with any standard physiologically and/or pharmaceutically acceptable carriers which are known in the art. The compositions should be sterile and contain a therapeutically effective amount of the antisense oligonucleotides in a unit of weight or volume suitable for administration to a patient. The term "pharmaceutically acceptable" means a non-toxic material that does not interfere with the effectiveness of the biological activity of the active ingredients. The term "physiologically acceptable" refers to a non-toxic material that is compatible with a biological system such as a cell, cell culture, tissue, or organism. The characteristics of the carrier will depend on the route of administration. Physiologically and pharmaceutically acceptable carriers include diluents, fillers, salts, buffers, stabilizers, solubilizers, and other materials which are well known in the art, as further described below. As used herein, a "vector" may be any of a number of nucleic acids into which a desired sequence may be inserted by restriction and ligation for transport between different genetic environments or for expression in a host cell. Vectors are typically composed of DNA although RNA vectors are also available. Vectors include, but are not limited to, plasmids, phagemids and virus genomes. A cloning vector is one which is able to replicate autonomously or integrated in the genome in a host cell, and which is further characterized by one or more endonuclease restriction sites at which the vector may be cut in a determinable fashion and into which a desired DNA sequence may be ligated such that the new recombinant vector retains its ability to replicate in the host cell. In the case of plasmids, replication of the desired sequence may occur many times as the plasmid increases in copy number within the host bacterium or just a single time per host before the host reproduces by mitosis. In the case of phage, replication may occur actively during a lytic phase or passively during a lysogenic phase. An expression vector is one into which a desired DNA sequence may be inserted by restriction and ligation such that it is operably joined to regulatory sequences and may be expressed as an RNA transcript. Vectors may further contain one or more marker sequences suitable for use in the identification of cells which have or have not been transformed or transfected with the vector. Markers include, for example, genes encoding proteins which increase or decrease either resistance or sensitivity to antibiotics or other compounds, genes which encode enzymes whose activities are detectable by standard assays known in the art (e.g., β-galactosidase, luciferase or alkaline phosphatase), and genes which visibly affect the phenotype of transformed or transfected cells, hosts, colonies or plaques (e.g., green fluorescent protein). Preferred vectors are those capable of autonomous replication and expression of the structural gene products present in the DNA segments to which they are operably joined. As used herein, a coding sequence and regulatory sequences are said to be "operably" joined when they are covalently linked in such a way as to place the expression or transcription of the coding sequence under the influence or control of the regulatory sequences. If it is desired that the coding sequences be translated into a functional protein, two DNA sequences are said to be operably joined if induction of a promoter in the 5' regulatory sequences results in the transcription of the coding sequence and if the nature of the linkage between the two DNA sequences does not (1) result in the introduction of a frame- shift mutation, (2) interfere with the ability of the promoter region to direct the transcription of the coding sequences, or (3) interfere with the ability of the corresponding RNA transcript to be translated into a protein. Thus, a promoter region would be operably joined to a coding sequence if the promoter region were capable of effecting transcription of that DNA sequence such that the resulting transcript might be translated into the desired protein or polypeptide. The precise nature of the regulatory sequences needed for gene expression may vary between species or cell types, but shall in general include, as necessary, 5' non-transcribed and 5' non-translated sequences involved with the initiation of transcription and translation respectively, such as a TATA box, capping sequence, CAAT sequence, and the like. Especially, such 5' non-transcribed regulatory sequences will include a promoter region which includes a promoter sequence for transcriptional control of the operably joined gene. Regulatory sequences may also include enhancer sequences or upstream activator sequences as desired. The vectors of the invention may optionally include 5' leader or signal sequences. The choice and design of an appropriate vector is within the ability and discretion of one of ordinary skill in the art. Expression vectors containing all the necessary elements for expression are commercially available and known to those skilled in the art. See, e.g., Sambrook et al., Molecular Cloning: A Laboratory Manual, Second Edition, Cold Spring Harbor Laboratory Press, 1989. Cells are genetically engineered by the introduction into the cells of heterologous DNA (RNA) encoding a cancer associated antigen polypeptide or fragment or variant thereof. That heterologous DNA (RNA) is placed under operable control of transcriptional elements to permit the expression of the heterologous DNA in the host cell.

Preferred systems for mRNA expression in mammalian cells are those such as pRc/CMV (available from Invitrogen, Carlsbad, CA) that contain a selectable marker such as a gene that confers G418 resistance (which facilitates the selection of stably transfected cell lines) and the human cytomegalovirus (CMV) enhancer-promoter sequences. Additionally, suitable for expression in primate or canine cell lines is the pCEP4 vector (Invitrogen), which contains an Epstein Barr Virus (EBV) origin of replication, facilitating the maintenance of plasmid as a multicopy extrachromosomal element. Another expression vector is the pEF- BOS plasmid containing the promoter of polypeptide Elongation Factor lα, which stimulates efficiently transcription in vitro. The plasmid is described by Mishizuma and Nagata (Nuc. Acids Res. 18:5322, 1990), and its use in transfection experiments is disclosed by, for example, Demoulin (Mol. Cell. Biol. 16:4710-4716, 1996). Still another preferred expression vector is an adeno virus, described by Stratford-Perricaudet, which is defective for El and E3 proteins (J. Clin. Invest. 90:626-630, 1992). The use of the adenovirus as an Adeno.Pl A recombinant for the expression of an antigen is disclosed by Warmer et al., in intradermal injection in mice for immunization against PI A (Int. J. Cancer, 67:303-310, 1996). Additional vectors for delivery of nucleic acid are provided below.

The invention also embraces so-called expression kits, which allow the artisan to prepare a desired expression vector or vectors. Such expression kits include at least separate portions of a vector and one or more of the previously discussed cancer associated antigen nucleic acid molecules. Other components may be added, as desired, as long as the previously mentioned nucleic acid molecules, which are required, are included. The invention also includes kits for amplification of a cancer associated antigen nucleic acid, including at least one pair of amplification primers which hybridize to a cancer associated antigen nucleic acid. The primers preferably are 12-32 nucleotides in length and are non-overlapping to prevent formation of "primer-dimers". One of the primers will hybridize to one strand of the cancer associated antigen nucleic acid and the second primer will hybridize to the complementary strand of the cancer associated antigen nucleic acid, in an arrangement which permits amplification of the cancer associated antigen nucleic acid. Selection of appropriate primer pairs is standard in the art. For example, the selection can be made with assistance of a computer program designed for such a purpose, optionally followed by testing the primers for amplification specificity and efficiency.

The invention also permits the construction of cancer associated antigen gene "knockouts" and transgenic overexpression in cells and in animals, providing materials for studying certain aspects of cancer and immune system responses to cancer.

The invention also provides isolated polypeptides (including whole proteins and partial proteins) encoded by the foregoing cancer associated antigen nucleic acids. Such polypeptides are useful, for example, alone or as fusion proteins to generate antibodies, as components of an immunoassay or diagnostic assay or as therapeutics. Cancer associated antigen polypeptides can be isolated from biological samples including tissue or cell homogenates, and can also be expressed recombinantly in a variety of prokaryotic and eukaryotic expression systems by constructing an expression vector appropriate to the expression system, introducing the expression vector into the expression system, and isolating the recombinantly expressed protein. Short polypeptides, including antigenic peptides (such as are presented by MHC molecules on the surface of a cell for immune recognition) also can be synthesized chemically using well-established methods of peptide synthesis.

A unique fragment of a cancer associated antigen polypeptide, in general, has the features and characteristics of unique fragments as discussed above in connection with nucleic acids. As will be recognized by those skilled in the art, the size of the unique fragment will depend upon factors such as whether the fragment constitutes a portion of a conserved protein domain. Thus, some regions of cancer associated antigens will require longer segments to be unique while others will require only short segments, typically between 5 and 12 amino acids (e.g. 5, 6, 7, 8, 9, 10, 11 or 12 or more amino acids including each integer up to the full length).

Unique fragments of a polypeptide preferably are those fragments which retain a distinct functional capability of the polypeptide. Functional capabilities which can be retained in a unique fragment of a polypeptide include interaction with antibodies, interaction with other polypeptides or fragments thereof, selective binding of nucleic acids or proteins, and enzymatic activity. One important activity is the ability to act as a signature for identifying the polypeptide. Another is the ability to complex with HLA and to provoke in a human an immune response. Those skilled in the art are well versed in methods for selecting unique amino acid sequences, typically on the basis of the ability of the unique fragment to selectively distinguish the sequence of interest from non-family members. A comparison of the sequence of the fragment to those on known databases typically is all that is necessary. The invention embraces variants of the cancer associated antigen polypeptides described above. As used herein, a "variant" of a cancer associated antigen polypeptide is a polypeptide which contains one or more modifications to the primary amino acid sequence of a cancer associated antigen polypeptide. Modifications which create a cancer associated antigen variant can be made to a cancer associated antigen polypeptide 1) to reduce or eliminate an activity of a cancer associated antigen polypeptide; 2) to enhance a property of a cancer associated antigen polypeptide, such as protein stability in an expression system or the stability of protein-protein binding; 3) to provide a novel activity or property to a cancer associated antigen polypeptide, such as addition of an antigenic epitope or addition of a detectable moiety; or 4) to provide equivalent or better binding to an HLA molecule.

Modifications to a cancer associated antigen polypeptide are typically made to the nucleic acid which encodes the cancer associated antigen polypeptide, and can include deletions, point mutations, truncations, amino acid substitutions and additions of amino acids or non-amino acid moieties. Alternatively, modifications can be made directly to the polypeptide, such as by cleavage, addition of a linker molecule, addition of a detectable moiety, such as biotin, addition of a fatty acid, substitution of L-amino acids with D-amino acids, and the like. Modifications also embrace fusion proteins comprising all or part of the cancer associated antigen amino acid sequence. One of skill in the art will be familiar with methods for predicting the effect on protein conformation of a change in protein sequence, and can thus "design" a variant cancer associated antigen polypeptide according to known methods. One example of such a method is described by Dahiyat and Mayo in Science 278:82-87, 1997, whereby proteins can be designed de novo. The method can be applied to a known protein to vary a only a portion of the polypeptide sequence. By applying the computational methods of Dahiyat and Mayo, specific variants of a cancer associated antigen polypeptide can be proposed and tested to determine whether the variant retains a desired conformation. Other computational and computer modeling methods for designing polypeptide mimetics which retain activity of the polypeptides described herein, as well as selection methods such as phage display of peptide libraries are known in the art.

In general, variants include cancer associated antigen polypeptides which are modified specifically to alter a feature of the polypeptide unrelated to its desired physiological activity. For example, cysteine residues can be substituted or deleted to prevent unwanted disulfide linkages. Similarly, certain amino acids can be changed to enhance expression of a cancer associated antigen polypeptide by eliminating proteolysis by proteases in an expression system (e.g., dibasic amino acid residues in yeast expression systems in which KEX2 protease activity is present).

Mutations of a nucleic acid which encode a cancer associated antigen polypeptide preferably preserve the amino acid reading frame of the coding sequence, and preferably do not create regions in the nucleic acid which are likely to hybridize to form secondary structures, such a hairpins or loops, which can be deleterious to expression of the variant polypeptide.

Mutations can be made by selecting an amino acid substitution, or by random mutagenesis of a selected site in a nucleic acid which encodes the polypeptide. Variant polypeptides are then expressed and tested for one or more activities to determine which mutation provides a variant polypeptide with the desired properties. Further mutations can be made to variants (or to non-variant cancer associated antigen polypeptides) which are silent as to the amino acid sequence of the polypeptide, but which provide preferred codons for translation in a particular host. The preferred codons for translation of a nucleic acid in, e.g., E. coli, are well known to those of ordinary skill in the art. Still other mutations can be made to the noncoding sequences of a cancer associated antigen gene or cDNA clone to enhance expression of the polypeptide. The activity of variants of cancer associated antigen polypeptides can be tested by cloning the gene encoding the variant cancer associated antigen polypeptide into a bacterial or mammalian expression vector, introducing the vector into an appropriate host cell, expressing the variant cancer associated antigen polypeptide, and testing for a functional capability of the cancer associated antigen polypeptides as disclosed herein. For example, the variant cancer associated antigen polypeptide can be tested for reaction with autologous or allogeneic sera as disclosed in the Examples. Preparation of other variant polypeptides may favor testing of other activities, as will be known to one of ordinary skill in the art. The skilled artisan will also realize that conservative amino acid substitutions may be made in cancer associated antigen polypeptides to provide functionally equivalent variants of the foregoing polypeptides, i.e, the variants retain the functional capabilities of the cancer associated antigen polypeptides. As used herein, a "conservative amino acid substitution" refers to an amino acid substitution which does not alter the relative charge or size characteristics of the protein in which the amino acid substitution is made. Variants can be prepared according to methods for altering polypeptide sequence known to one of ordinary skill in the art such as are found in references which compile such methods, e.g. Molecular Cloning: A Laboratory Manual, J. Sambrook, et al., eds., Second Edition, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1989, or Current Protocols in Molecular Biology, F.M. Ausubel, et al., eds., John Wiley & Sons, Inc., New York. Exemplary functionally equivalent variants of the cancer associated antigen polypeptides include conservative amino acid substitutions of in the amino acid sequences of proteins disclosed herein. Conservative substitutions of amino acids include substitutions made amongst amino acids within the following groups: (a) M, I, L, V; (b) F, Y, W; (c) K, R, H; (d) A, G; (e) S, T; (f) Q, N; and (g) E, D.

For example, upon determining that a peptide derived from a cancer associated antigen polypeptide is presented by an MHC molecule and recognized by CTLs, one can make conservative amino acid substitutions to the amino acid sequence of the peptide, particularly at residues which are thought not to be direct contact points with the MHC molecule. For example, methods for identifying functional variants of HLA class II binding peptides are provided in a published PCT application of Strominger and Wucherpfennig (PCT/US96/03182). Peptides bearing one or more amino acid substitutions also can be tested for concordance with known HLA MHC motifs prior to synthesis using, e.g. the computer program described by D'Amaro and Drijfhout (D'Amaro et al., Human Immunol. 43:13-18, 1995; Drijfhout et al., Human Immunol. 43:1-12, 1995). The substituted peptides can then be tested for binding to the MHC molecule and recognition by CTLs when bound to MHC. These variants can be tested for improved stability and are useful, inter alia, in vaccine compositions.

Conservative amino-acid substitutions in the amino acid sequence of cancer associated antigen polypeptides to produce functionally equivalent variants of cancer associated antigen polypeptides typically are made by alteration of a nucleic acid encoding a cancer associated antigen polypeptide. Such substitutions can be made by a variety of methods known to one of ordinary skill in the art. For example, amino acid substitutions may be made by PCR-directed mutation, site-directed mutagenesis according to the method of Kunkel (Kunkel, Proc. Nat. Acad. Sci. U.S.A. 82: 488-492, 1985), or by chemical synthesis of a gene encoding a cancer associated antigen polypeptide. Where amino acid substitutions are made to a small unique fragment of a cancer associated antigen polypeptide, such as an antigenic epitope recognized by autologous or allogeneic sera or cytolytic T lymphocytes, the substitutions can be made by directly synthesizing the peptide. The activity of functionally equivalent fragments of cancer associated antigen polypeptides can be tested by cloning the gene encoding the altered cancer associated antigen polypeptide into a bacterial or mammalian expression vector, introducing the vector into an appropriate host cell, expressing the altered cancer associated antigen polypeptide, and testing for a functional capability of the cancer associated antigen polypeptides as disclosed herein. Peptides which are chemically synthesized can be tested directly for function, e.g., for binding to antisera recognizing associated antigens.

The invention as described herein has a number of uses, some of which are described elsewhere herein. First, the invention permits production and/or isolation of the cancer associated antigen protein molecules. A variety of methodologies well-known to the skilled practitioner can be utilized to obtain isolated cancer associated antigen molecules. The polypeptide may be purified from cells which naturally produce the polypeptide by chromatographic means or immunological recognition. Alternatively, an expression vector may be introduced into cells to cause production of the polypeptide. In another method, mRNA transcripts may be microinjected or otherwise introduced into cells to cause production of the encoded polypeptide. Translation of mRNA in cell-free extracts such as the reticulocyte lysate system also may be used to produce polypeptide. Those skilled in the art also can readily follow known methods for isolating cancer associated antigen polypeptides. These include, but are not limited to, immunochromatography, HPLC, size-exclusion chromatography, ion-exchange chromatography and immune-affinity chromatography. The isolation and identification of cancer associated antigen genes also makes it possible for the artisan to diagnose a disorder characterized by expression of cancer associated antigens. These methods involve determining expression of one or more cancer associated antigen nucleic acids, and/or encoded cancer associated antigen polypeptides and/or peptides derived therefrom. In the former situation, such determinations can be carried out via any standard nucleic acid determination assay, including the polymerase chain reaction, or assaying with labeled hybridization probes. In the latter situation, such determinations can be carried out by screening patient antisera for recognition of the polypeptide.

The invention also makes it possible isolate proteins which bind to cancer associated antigens as disclosed herein, including antibodies and cellular binding partners of the cancer associated antigens. Additional uses are described further herein.

The invention also provides, in certain embodiments, "dominant negative" polypeptides derived from cancer associated antigen polypeptides. A dominant negative polypeptide is an inactive variant of a protein, which, by interacting with the cellular machinery, displaces an active protein from its interaction with the cellular machinery or competes with the active protein, thereby reducing the effect of the active protein. For example, a dominant negative receptor which binds a ligand but does not transmit a signal in response to binding of the ligand can reduce the biological effect of expression of the ligand. Likewise, a dominant negative catalytically-inactive kinase which interacts normally with target proteins but does not phosphorylate the target proteins can reduce phosphorylation of the target proteins in response to a cellular signal. Similarly, a dominant negative transcription factor which binds to a promoter site in the control region of a gene but does not increase gene transcription can reduce the effect of a normal transcription factor by occupying promoter binding sites without increasing transcription.

The end result of the expression of a dominant negative polypeptide in a cell is a reduction in function of active proteins. One of ordinary skill in the art can assess the potential for a dominant negative variant of a protein, and using standard mutagenesis techniques to create one or more dominant negative variant polypeptides. For example, given the teachings contained herein of breast, gastric and prostate cancer associated antigens, especially those which are similar to known proteins which have known activities, one of ordinary skill in the art can modify the sequence of the cancer associated antigens by site- specific mutagenesis, scanning mutagenesis, partial gene deletion or truncation, and the like. See, e.g., U.S. Patent No. 5,580,723 and Sambrook et al., Molecular Cloning: A Laboratory Manual, Second Edition, Cold Spring Harbor Laboratory Press, 1989. The skilled artisan then can test the population of mutagenized polypeptides for diminution in a selected and/or for retention of such an activity. Other similar methods for creating and testing dominant negative variants of a protein will be apparent to one of ordinary skill in the art. The invention also involves agents such as polypeptides which bind to cancer associated antigen polypeptides. Such binding agents can be used, for example, in screening assays to detect the presence or absence of cancer associated antigen polypeptides and complexes of cancer associated antigen polypeptides and their binding partners and in purification protocols to isolated cancer associated antigen polypeptides and complexes of cancer associated antigen polypeptides and their binding partners. Such agents also can be used to inhibit the native activity of the cancer associated antigen polypeptides, for example, by binding to such polypeptides.

The invention, therefore, embraces peptide binding agents which, for example, can be antibodies or fragments of antibodies having the ability to selectively bind to cancer associated antigen polypeptides. Antibodies include polyclonal and monoclonal antibodies, prepared according to conventional methodology.

Significantly, as is well-known in the art, only a small portion of an antibody molecule, the paratope, is involved in the binding of the antibody to its epitope (see, in general, Clark, W.R. (1986) The Experimental Foundations of Modern Immunology Wiley & Sons, Inc., New York; Roitt, I. (1991) Essential Immunology. 7th Ed., Blackwell Scientific Publications, Oxford). The pFc' and Fc regions, for example, are effectors of the complement cascade but are not involved in antigen binding. An antibody from which the pFc' region has been enzymatically cleaved, or which has been produced without the pFc' region, designated an F(ab')₂ fragment, retains both of the antigen binding sites of an intact antibody. Similarly, an antibody from which the Fc region has been enzymatically cleaved, or which has been produced without the Fc region, designated an Fab fragment, retains one of the antigen binding sites of an intact antibody molecule. Proceeding further, Fab fragments consist of a covalently bound antibody light chain and a portion of the antibody heavy chain denoted Fd. The Fd fragments are the major determinant of antibody specificity (a single Fd fragment may be associated with up to ten different light chains without altering antibody specificity) and Fd fragments retain epitope-binding ability in isolation. Within the antigen-binding portion of an antibody, as is well-known in the art, there are complementarity determining regions (CDRs), which directly interact with the epitope of the antigen, and framework regions (FRs), which maintain the tertiary structure of the paratope (see, in general, Clark, 1986; Roitt, 1991). In both the heavy chain Fd fragment and the light chain of IgG immunoglobulins, there are four framework regions (FR1 through FR4) separated respectively by three complementarity determining regions (CDRl through CDR3). The CDRs, and in particular the CDR3 regions, and more particularly the heavy chain CDR3, are largely responsible for antibody specificity.

It is now well-established in the art that the non-CDR regions of a mammalian antibody may be replaced with similar regions of conspecific or heterospecific antibodies while retaining the epitopic specificity of the original antibody. This is most clearly manifested in the development and use of "humanized" antibodies in which non-human CDRs are covalently joined to human FR and/or Fc/pFc' regions to produce a functional antibody. See, e.g., U.S. patents 4,816,567, 5,225,539, 5,585,089, 5,693,762 and 5,859,205.

Thus, for example, PCT International Publication Number WO 92/04381 teaches the production and use of humanized murine RSV antibodies in which at least a portion of the murine FR regions have been replaced by FR regions of human origin. Such antibodies, including fragments of intact antibodies with antigen-binding ability, are often referred to as "chimeric" antibodies.

Thus, as will be apparent to one of ordinary skill in the art, the present invention also provides for F(ab')₂, Fab, Fv and Fd fragments; chimeric antibodies in which the Fc and/or FR and/or CDRl and/or CDR2 and/or light chain CDR3 regions have been replaced by homologous human or non-human sequences; chimeric F(ab')₂ fragment antibodies in which the FR and/or CDRl and/or CDR2 and/or light chain CDR3 regions have been replaced by homologous human or non-human sequences; chimeric Fab fragment antibodies in which the FR and/or CDRl and/or CDR2 and/or light chain CDR3 regions have been replaced by homologous human or non-human sequences; and chimeric Fd fragment antibodies in which the FR and or CDRl and/or CDR2 regions have been replaced by homologous human or non- human sequences. The present invention also includes so-called single chain antibodies.

Thus, the invention involves polypeptides of numerous size and type that bind specifically to cancer associated antigen polypeptides, and complexes of both cancer associated antigen polypeptides and their binding partners. These polypeptides may be derived also from sources other than antibody technology. For example, such polypeptide binding agents can be provided by degenerate peptide libraries which can be readily prepared in solution, in immobilized form or as phage display libraries. Combinatorial libraries also can be synthesized of peptides containing one or more amino acids. Libraries further can be synthesized of peptoids and non-peptide synthetic moieties. Phage display can be particularly effective in identifying binding peptides useful according to the invention. Briefly, one prepares a phage library (using e.g. ml 3, fd, or lambda phage), displaying inserts from 4 to about 80 amino acid residues using conventional procedures. The inserts may represent, for example, a completely degenerate or biased array. One then can select phage-bearing inserts which bind to the cancer associated antigen polypeptide. This process can be repeated through several cycles of reselection of phage that bind to the cancer associated antigen polypeptide. Repeated rounds lead to enrichment of phage bearing particular sequences. DNA sequence analysis can be conducted to identify the sequences of the expressed polypeptides. The minimal linear portion of the sequence that binds to the cancer associated antigen polypeptide can be determined. One can repeat the procedure using a biased library containing inserts containing part or all of the minimal linear portion plus one or more additional degenerate residues upstream or downstream thereof. Yeast two-hybrid screening methods also may be used to identify polypeptides that bind to the cancer associated antigen polypeptides. Thus, the cancer associated antigen polypeptides of the invention, or a fragment thereof, can be used to screen peptide libraries, including phage display libraries, to identify and select peptide binding partners of the cancer associated antigen polypeptides of the invention. Such molecules can be used, as described, for screening assays, for purification protocols, for interfering directly with the functioning of cancer associated antigen and for other purposes that will be apparent to those of ordinary skill in the art.

As detailed herein, the foregoing antibodies and other binding molecules may be used for example to identify tissues expressing protein or to purify protein. Antibodies also may be coupled to specific diagnostic labeling agents for imaging of cells and tissues that express cancer associated antigens or to therapeutically useful agents according to standard coupling procedures. Diagnostic agents include, but are not limited to, barium sulfate, iocetamic acid, iopanoic acid, ipodate calcium, diatrizoate sodium, diatrizoate meglumine, metrizamide, tyropanoate sodium and radiodiagnostics including positron emitters such as fluorine- 18 and carbon- 11 , gamma emitters such as iodine- 123, technetium-99m, iodine- 131 and indium- 111, and nuclides for nuclear magnetic resonance such as fluorine and gadolinium. Other diagnostic agents useful in the invention will be apparent to one of ordinary skill in the art. As used herein, "therapeutically useful agents" include any therapeutic molecule which desirably is targeted selectively to a cell expressing one of the cancer antigens disclosed herein, including antineoplastic agents, radioiodinated compounds, toxins, other cytostatic or cytolytic drugs, and so forth. Antineoplastic therapeutics are well known and include: aminoglutethimide, azathioprine, bleomycin sulfate, busulfan, carmustine, chlorambucil, cisplatin, cyclophosphamide, cyclosporine, cytarabidine, dacarbazine, dactinomycin, daunorubicin, doxorubicin, taxol, etoposide, fluorouracil, interferon-α, lomustine, mercaptopurine, methotrexate, mitotane, procarbazine HCl, thioguanine, vinblastine sulfate and vincristine sulfate. Additional antineoplastic agents include those disclosed in Chapter 52, Antineoplastic Agents (Paul Calabresi and Bruce A. Chabner), and the introduction thereto, 1202-1263, of Goodman and Gilman's "The Pharmacological Basis of Therapeutics", Eighth Edition, 1990, McGraw-Hill, Inc. (Health Professions Division). Toxins can be proteins such as, for example, pokeweed anti- viral protein, cholera toxin, pertussis toxin, ricin, gelonin, abrin, diphtheria exotoxin, or Pseudomonas exotoxin. Toxin moieties can also be high energy-emitting radionuclides such as cobalt-60.

In the foregoing methods and compositions, antibodies prepared according to the invention also preferably are specific for the cancer associated antigen/MHC complexes described herein.

When "disorder" is used herein, it refers to any pathological condition where the cancer associated antigens are expressed. An example of such a disorder is cancer, including breast, gastric and prostate cancer as particular examples.

Samples of tissue and/or cells for use in the various methods described herein can be obtained through standard methods such as tissue biopsy, including punch biopsy and cell scraping, and collection of blood or other bodily fluids by aspiration or other methods. In certain embodiments of the invention, an immunoreactive cell sample is removed from a subject. By "immunoreactive cell" is meant a cell which can mature into an immune cell (such as a B cell, a helper T cell, or a cytolytic T cell) upon appropriate stimulation. Thus immunoreactive cells include CD34⁺ hematopoietic stem cells, immature T cells and immature B cells. When it is desired to produce cytolytic T cells which recognize a cancer associated antigen, the immunoreactive cell is contacted with a cell which expresses a cancer associated antigen under conditions favoring production, differentiation and/or selection of cytolytic T cells; the differentiation of the T cell precursor into a cytolytic T cell upon exposure to antigen is similar to clonal selection of the immune system.

Some therapeutic approaches based upon the disclosure are premised on a response by a subject's immune system, leading to lysis of antigen presenting cells, such as breast, gastric or prostate cancer cells which present one or more cancer associated antigens. One such approach is the administration of autologous CTLs specific to a cancer associated antigen MHC complex to a subject with abnormal cells of the phenotype at issue. It is within the ability of one of ordinary skill in the art to develop such CTLs in vitro. An example of a method for T cell differentiation is presented in International Application number

PCT US96/05607. Generally, a sample of cells taken from a subject, such as blood cells, are contacted with a cell presenting the complex and capable of provoking CTLs to proliferate. The target cell can be a transfectant, such as a COS cell. These transfectants present the desired complex at their surface and, when combined with a CTL of interest, stimulate its proliferation. COS cells are widely available, as are other suitable host cells. Specific production of CTL clones is well known in the art. The clonally expanded autologous CTLs then are administered to the subject.

CTL proliferation can be increased by increasing the level of tryptophan in T cell cultures, by inhibiting enzymes which catabolize tryptophan, such as indoleamine 2,3- dioxygenase (IDO), or by adding tryptophan to the culture. Proliferation of T cells is enhanced by increasing the rate of proliferation and/or extending the number of divisions of the T cells in culture. In addition, increasing tryptophan in T cell cultures also enhances the lytic activity of the T cells grown in culture.

Another method for selecting antigen-specific CTL clones has recently been described (Airman et al., Science 274:94-96, 1996; Dunbar et al., Curr. Biol. 8:413-416, 1998), in which fluorogenic tetramers of MHC class I molecule/peptide complexes are used to detect specific CTL clones. Briefly, soluble MHC class I molecules are folded in vitro in the presence of β₂- microglobulin and a peptide antigen which binds the class I molecule. After purification, the MHC/peptide complex is purified and labeled with biotin. Tetramers are formed by mixing the biotinylated peptide-MHC complex with labeled avidin (e.g. phycoerythrin) at a molar ratio or 4:1. Tetramers are then contacted with a source of CTLs such as peripheral blood or lymph node. The tetramers bind CTLs which recognize the peptide antigen/MHC class I complex. Cells bound by the tetramers can be sorted by fluorescence activated cell sorting to isolate the reactive CTLs. The isolated CTLs then can be expanded in vitro for use as described herein.

To detail a therapeutic methodology, referred to as adoptive transfer (Greenberg, J. Immunol. 136(5): 1917, 1986; Riddel et al., Science 257: 238, 1992; Lynch et al, Eur. J. Immunol. 21: 1403-1410,1991; Kast et al., Cell 59: 603-614, 1989), cells presenting the desired complex (e.g., dendritic cells) are combined with CTLs leading to proliferation of the CTLs specific thereto. The proliferated CTLs are then administered to a subject with a cellular abnormality which is characterized by certain of the abnormal cells presenting the particular complex. The CTLs then lyse the abnormal cells, thereby achieving the desired therapeutic goal.

The foregoing therapy assumes that at least some of the subject's abnormal cells present the relevant HLA/cancer associated antigen complex. This can be determined very easily, as the art is very familiar with methods for identifying cells which present a particular HLA molecule, as well as how to identify cells expressing DNA of the pertinent sequences, in this case a cancer associated antigen sequence. Once cells presenting the relevant complex are identified via the foregoing screening methodology, they can be combined with a sample from a patient, where the sample contains CTLs. If the complex presenting cells are lysed by the mixed CTL sample, then it can be assumed that a cancer associated antigen is being presented, and the subject is an appropriate candidate for the therapeutic approaches set forth supra.

Adoptive transfer is not the only form of therapy that is available in accordance with the invention. CTLs can also be provoked in vivo, using a number of approaches. One approach is the use of non-proliferative cells expressing the complex. The cells used in this approach may be those that normally express the complex, such as irradiated tumor cells or cells transfected with one or both of the genes necessary for presentation of the complex (i.e. the antigenic peptide and the presenting HLA molecule). Chen et al. (Proc. Natl. Acad. Sci. USA 88: 110-114,1991) exemplifies this approach, showing the use of transfected cells expressing HPV-E7 peptides in a therapeutic regime. Various cell types may be used. Similarly, vectors carrying one or both of the genes of interest may be used. Viral or bacterial vectors are especially preferred. For example, nucleic acids which encode a cancer associated antigen polypeptide or peptide may be operably linked to promoter and enhancer sequences which direct expression of the cancer associated antigen polypeptide or peptide in certain tissues or cell types. The nucleic acid may be incorporated into an expression vector. Expression vectors may be unmodified extrachromosomal nucleic acids, plasmids or viral genomes constructed or modified to enable insertion of exogenous nucleic acids, such as those encoding cancer associated antigens, as described elsewhere herein. Nucleic acids encoding one or more cancer associated antigens also may be inserted into a retro viral genome, thereby facilitating integration of the nucleic acid into the genome of the target tissue or cell type. In these systems, the gene of interest is carried by a microorganism, e.g., a Vaccinia virus, pox virus, herpes simplex virus, retrovirus or adenovirus, and the materials de facto "infect" host cells. The cells which result present the complex of interest, and are recognized by autologous CTLs, which then proliferate.

A similar effect can be achieved by combining the cancer associated antigen or a stimulatory fragment thereof with an adjuvant to facilitate incorporation into antigen presenting cells in vivo. The cancer associated antigen polypeptide is processed to yield the peptide partner of the HLA molecule while a cancer associated antigen peptide may be presented without the need for further processing. Generally, subjects can receive an intradermal injection of an effective amount of the cancer associated antigen. Initial doses can be followed by booster doses, following immunization protocols standard in the art. Preferred cancer associated antigens include those found to react with allogeneic cancer antisera, shown in the examples below. The invention involves the use of various materials disclosed herein to "immunize" subjects or as "vaccines". As used herein, "immunization" or "vaccination" means increasing or activating an immune response against an antigen. It does not require elimination or eradication of a condition but rather contemplates the clinically favorable enhancement of an immune response toward an antigen. Generally accepted animal models can be used for testing of immunization against cancer using a cancer associated antigen nucleic acid. For example, human cancer cells can be introduced into a mouse to create a tumor, and one or more cancer associated antigen nucleic acids can be delivered by the methods described herein. The effect on the cancer cells (e.g., reduction of tumor size) can be assessed as a measure of the effectiveness of the cancer associated antigen nucleic acid immunization. Of course, testing of the foregoing animal model using more conventional methods for immunization can include the administration of one or more cancer associated antigen polypeptides or peptides derived therefrom, optionally combined with one or more adjuvants and/or cytokines to boost the immune response. Methods for immunization, including formulation of a vaccine composition and selection of doses, route of administration and the schedule of administration (e.g. primary and one or more booster doses), are well known in the art. The tests also can be performed in humans, where the end point is to test for the presence of enhanced levels of circulating CTLs against cells bearing the antigen, to test for levels of circulating antibodies against the antigen, to test for the presence of cells expressing the antigen and so forth.

As part of the immunization compositions, one or more cancer associated antigens or stimulatory fragments thereof are administered with one or more adjuvants to induce an immune response or to increase an immvine response. An adjuvant is a substance incorporated into or administered with antigen which potentiates the immune response. Adjuvants may enhance the immuno logical response by providing a reservoir of antigen (extracellularly or within macrophages), activating macrophages and stimulating specific sets of lymphocytes. Adjuvants of many kinds are well known in the art. Specific examples of adjuvants include monophosphoryl lipid A (MPL, SmithKline Beecham), a congener obtained after purification and acid hydrolysis of Salmonella minnesota Re 595 lipopolysaccharide; saponins including QS21 (SmithKline Beecham), a pure QA-21 saponin purified from Quillja saponaria extract; DQS21, described in PCT application WO96/33739 (SmithKline Beecham); QS-7, QS-17, QS-18, and QS-L1 (So et al., Mol. Cells 7:178-186, 1997); incomplete Freund's adjuvant; complete Freund's adjuvant; montanide; alum; CpG oligonucleotides (see e.g. Kreig et al., Nature 374:546-9, 1995); and various water-in-oil emulsions prepared from biodegradable oils such as squalene and/or tocopherol. Preferably, the peptides are administered mixed with a combination of DQS21/MPL. The ratio of DQS21 to MPL typically will be about 1 :10 to 10:1, preferably about l:5 to 5:l and more preferably about 1:1. Typically for human administration, DQS21 and MPL will be present in a vaccine formulation in the range of about 1 μg to about 100 μg. Other adjuvants are known in the art and can be used in the invention (see, e.g. Goding, Monoclonal Antibodies: Principles and Practice, 2nd Ed., 1986). Methods for the preparation of mixtures or emulsions of peptide and adjuvant are well known to those of skill in the art of vaccination.

Other agents which stimulate the immune response of the subject can also be administered to the subject. For example, other cytokines are also useful in vaccination protocols as a result of their lymphocyte regulatory properties. Many other cytokines useful for such purposes will be known to one of ordinary skill in the art, including interleukin-12 (IL-12) which has been shown to enhance the protective effects of vaccines (see, e.g., Science 268: 1432-1434, 1995), GM-CSF and IL-18. Thus cytokines can be administered in conjunction with antigens and adjuvants to increase the immune response to the antigens. There are a number of immune response potentiating compounds that can be used in vaccination protocols. These include costimulatory molecules provided in either protein or nucleic acid form. Such costimulatory molecules include the B7-1 and B7-2 (CD80 and CD86 respectively) molecules which are expressed on dendritic cells (DC) and interact with the CD28 molecule expressed on the T cell. This interaction provides costimulation (signal 2) to an antigen/MHC/TCR stimulated (signal 1) T cell, increasing T cell proliferation and effector function. B7 also interacts with CTLA4 (CD 152) on T cells and studies involving CTLA4 and B7 ligands indicate that the B7-CTLA4 interaction can enhance antitumor immunity and CTL proliferation (Zheng P., et al. Proc. Natl. Acad. Sci. USA 95 (11):6284-6289 (1998)).

B7 typically is not expressed on tumor cells so they are not efficient antigen presenting cells (APCs) for T cells. Induction of B7 expression would enable the tumor cells to stimulate more efficiently CTL proliferation and effector function. A combination of B7/IL-6/IL-12 costimulation has been shown to induce IFN-gamma and a Thl cytokine profile in the T cell population leading to further enhanced T cell activity (Gajewski et al., J. Immunol, 154:5637- 5648 (1995)). Tumor cell transfection with B7 has ben discussed in relation to in vitro CTL expansion for adoptive transfer immunotherapy by Wang et al., (J. Immunol, 19: 1-8 (1986)). Other delivery mechanisms for the B7 molecule would include nucleic acid (naked DNA) immunization (Kim J., et al. Nat Biotechnol, 15:7:641-646 (1997)) and recombinant viruses such as adeno and pox (Wendtner et al., Gene Ther., 4:7:726-735 (1997)). These systems are all amenable to the construction and use of expression cassettes for the coexpression of B7 with other molecules of choice such as the antigens or fragment(s) of antigens discussed herein (including polytopes) or cytokines. These delivery systems can be used for induction of the appropriate molecules in vitro and for in vivo vaccination situations. The use of anti- CD28 antibodies to directly stimulate T cells in vitro and in vivo could also be considered. Similarly, the inducible co-stimulatory molecule ICOS which induces T cell responses to foreign antigen could be modulated, for example, by use of anti-ICOS antibodies (Hutloff et al., Nature 397:263-266, 1999). Lymphocyte function associated antigen-3 (LFA-3) is expressed on APCs and some tumor cells and interacts with CD2 expressed on T cells. This interaction induces T cell IL-2 and IFN-gamma production and can thus complement but not substitute, the B7/CD28 costimulatory interaction (Parra et al., J. Immunol, 158:637-642 (1997), Fenton et al., J. Immunother., 21:2:95-108 (1998)). Lymphocyte function associated antigen- 1 (LFA-1) is expressed on leukocytes and interacts with ICAM-1 expressed on APCs and some tumor cells. This interaction induces T cell IL-2 and IFN-gamma production and can thus complement but not substitute, the B7/CD28 costimulatory interaction (Fenton et al., J. Immunother., 21:2:95-108 (1998)). LFA- 1 is thus a further example of a costimulatory molecule that could be provided in a vaccination protocol in the various ways discussed above for B7.

Complete CTL activation and effector function requires Th cell help through the interaction between the Th cell CD40L (CD40 ligand) molecule and the CD40 molecule expressed by DCs (Ridge et al., Nature, 393:474 (1998), Bennett et al., Nature, 393:478 (1998), Schoenberger et al., Nature, 393:480 (1998)). This mechanism of this costimulatory signal is likely to involve upregulation of B7 and associated IL-6/IL-12 production by the DC (APC). The CD40-CD40L interaction thus complements the signal 1 (antigen/MHC-TCR) and signal 2 (B7-CD28) interactions.

The use of anti-CD40 antibodies to stimulate DC cells directly, would be expected to enhance a response to tumor antigens which are normally encountered outside of a inflammatory context or are presented by non-professional APCs (tumor cells). In these situations Th help and B7 costimulation signals are not provided. This mechanism might be used in the context of antigen pulsed DC based therapies or in situations where Th epitopes have not been defined within known cancer antigen precursors.

A cancer associated antigen polypeptide, or a fragment thereof, also can be used to isolate their native binding partners. Isolation of such binding partners may be performed according to well-known methods. For example, isolated cancer associated antigen polypeptides can be attached to a substrate (e.g., chromatographic media, such as polystyrene beads, or a filter), and then a solution suspected of containing the binding partner may be applied to the substrate. If a binding partner which can interact with cancer associated antigen polypeptides is present in the solution, then it will bind to the substrate-bound cancer associated antigen polypeptide. The binding partner then may be isolated. It will also be recognized that the invention embraces the use of the cancer associated antigen cDNA sequences in expression vectors, as well as to transfect host cells and cell lines, be these prokaryotic (e.g., E. coli), or eukaryotic (e.g., dendritic cells, B cells, CHO cells, COS cells, yeast expression systems and recombinant baculovirus expression in insect cells). Especially useful are mammalian cells such as human, mouse, hamster, pig, goat, primate, etc. They may be of a wide variety of tissue types, and include primary cells and cell lines.

Specific examples include keratinocytes, peripheral blood leukocytes, bone marrow stem cells and embryonic stem cells. The expression vectors require that the pertinent sequence, i.e., those nucleic acids described supra, be operably linked to a promoter.

The invention also contemplates delivery of nucleic acids, polypeptides or peptides for vaccination. Delivery of polypeptides and peptides can be accomplished according to standard vaccination protocols which are well known in the art. In another embodiment, the delivery of nucleic acid is accomplished by ex vivo methods, i.e. by removing a cell from a subject, genetically engineering the cell to include a cancer associated antigen, and reintroducing the engineered cell into the subject. One example of such a procedure is outlined in U.S. Patent 5,399,346 and in exhibits submitted in the file history of that patent, all of which are publicly available documents. In general, it involves introduction in vitro of a functional copy of a gene into a cell(s) of a subject, and returning the genetically engineered cell(s) to the subject. The functional copy of the gene is under operable control of regulatory elements which permit expression of the gene in the genetically engineered cell(s). Numerous transfection and transduction techniques as well as appropriate expression vectors are well known to those of ordinary skill in the art, some of which are described in PCT application WO95/00654. In vivo nucleic acid delivery using vectors such as viruses and targeted liposomes also is contemplated according to the invention.

In preferred embodiments, a virus vector for delivering a nucleic acid encoding a cancer associated antigen is selected from the group consisting of adenoviruses, adeno- associated viruses, poxviruses including vaccinia viruses and attenuated poxviruses, Semliki Forest virus, Venezuelan equine encephalitis virus, retroviruses, Sindbis virus, and Ty viruslike particle. Examples of viruses and virus-like particles which have been used to deliver exogenous nucleic acids include: replication-defective adenoviruses (e.g., Xiang et al., Virology 219:220-227, 1996; Eloit et al., J. Virol 7:5375-5381, 1997; Chengalvala et al., Vaccine 15:335-339, 1997), a modified retrovirus (Townsend et al., J. Virol 71:3365-3374, 1997), a nonreplicating retrovirus (Irwin et al., J. Virol. 68:5036-5044, 1994), a replication defective Semliki Forest virus (Zhao et al., Proc. Natl. Acad. Sci. USA 92:3009-3013, 1995), canarypox virus and highly attenuated vaccinia virus derivative (Paoletti, Proc. Natl Acad. Sci. USA 93: 11349-11353, 1996), non-replicative vaccinia virus (Moss, Proc. Natl Acad. Sci. USA 93:11341-11348, 1996), replicative vaccinia virus (Moss, Dev. Biol Stand. 82:55-63, 1994), Venzuelan equine encephalitis virus (Davis et al., J. Virol. 70:3781-3787, 1996), Sindbis virus (Pugachev et al., Virology 212:587-594, 1995), and Ty virus-like particle (Allsopp et al., Eur. J. Immunol 26:1951-1959, 1996). In preferred embodiments, the virus vector is an adenovirus.

Another preferred virus for certain applications is the adeno-associated virus, a double-stranded DNA virus. The adeno-associated virus is capable of infecting a wide range of cell types and species and can be engineered to be replication-deficient. It further has advantages, such as heat and lipid solvent stability, high transduction frequencies in cells of diverse lineages, including hematopoietic cells, and lack of superinfection inhibition thus allowing multiple series of transductions. The adeno-associated virus can integrate into human cellular DNA in a site-specific manner, thereby minimizing the possibility of insertional mutagenesis and variability of inserted gene expression. In addition, wild-type adeno-associated virus infections have been followed in tissue culture for greater than 100 passages in the absence of selective pressure, implying that the adeno-associated virus genomic integration is a relatively stable event. The adeno-associated virus can also function in an extrachromosomal fashion.

In general, other preferred viral vectors are based on non-cytopathic eukaryotic viruses in which non-essential genes have been replaced with the gene of interest. Non-cytopathic viruses include retro viruses, the life cycle of which involves reverse transcription of genomic viral RNA into DNA with subsequent proviral integration into host cellular DNA. Adenoviruses and retroviruses have been approved for human gene therapy trials. In general, the retroviruses are replication-deficient (i.e., capable of directing synthesis of the desired proteins, but incapable of manufacturing an infectious particle). Such genetically altered retroviral expression vectors have general utility for the high-efficiency transduction of genes in vivo. Standard protocols for producing replication-deficient retroviruses (including the steps of incorporation of exogenous genetic material into a plasmid, transfection of a packaging cell lined with plasmid, production of recombinant retroviruses by the packaging cell line, collection of viral particles from tissue culture media, and infection of the target cells with viral particles) are provided in Kriegler, M., "Gene Transfer and Expression, A Laboratory Manual," W.H. Freeman Co., New York (1990) and Murry, E.J. Ed. "Methods in Molecular Biology," vol. 7, Humana Press, Inc., Clifton, New Jersey (1991).

Preferably the foregoing nucleic acid delivery vectors: (1) contain exogenous genetic material that can be transcribed and translated in a mammalian cell and that can induce an immune response in a host, and (2) contain on a surface a ligand that selectively binds to a receptor on the surface of a target cell, such as a mammalian cell, and thereby gains entry to the target cell.

Various techniques may be employed for introducing nucleic acids of the invention into cells, depending on whether the nucleic acids are introduced in vitro or in vivo in a host. Such techniques include transfection of nucleic acid-CaPO₄ precipitates, transfection of nucleic acids associated with DEAE, transfection or infection with the foregoing viruses including the nucleic acid of interest, liposome mediated transfection, and the like. For certain uses, it is preferred to target the nucleic acid to particular cells. In such instances, a vehicle used for delivering a nucleic acid of the invention into a cell (e.g., a retrovirus, or other virus; a liposome) can have a targeting molecule attached thereto. For example, a molecule such as an antibody specific for a surface membrane protein on the target cell or a ligand for a receptor on the target cell can be bound to or incorporated within the nucleic acid delivery vehicle. Preferred antibodies include antibodies which selectively bind a cancer associated antigen, alone or as a complex with a MHC molecule. Especially preferred are monoclonal antibodies. Where liposomes are employed to deliver the nucleic acids of the invention, proteins which bind to a surface membrane protein associated with endocytosis may be incorporated into the liposome formulation for targeting and/or to facilitate uptake. Such proteins include capsid proteins or fragments thereof tropic for a particular cell type, antibodies for proteins which undergo internalization in cycling, proteins that target intracellular localization and enhance intracellular half life, and the like. Polymeric delivery systems also have been used successfully to deliver nucleic acids into cells, as is known by those skilled in the art. Such systems even permit oral delivery of nucleic acids.

The therapeutics of the invention can be administered by any conventional route, including injection or by gradual infusion over time. The administration may, for example, be oral, intravenous, intraperitoneal, intramuscular, intracavity, subcutaneous, or transdermal. When cancer associated antigen peptides are used for vaccination, modes of administration which effectively deliver the cancer associated antigen and adjuvant, such that an immune response to the antigen is increased, can be used. For administration of a cancer associated antigen peptide in adjuvant, preferred methods include intradermal, intravenous, intramuscular and subcutaneous administration. Although these are preferred embodiments, the invention is not limited by the particular modes of administration disclosed herein.

Standard references in the art (e.g., Remington 's Pharmaceutical Sciences, 18th edition, 1990) provide modes of administration and formulations for delivery of immunogens with adjuvant or in a non-adjuvant carrier. When antibodies are used therapeutically, a preferred route of administration is by pulmonary aerosol. Techniques for preparing aerosol delivery systems containing antibodies are well known to those of skill in the art. Generally, such systems should utilize components which will not significantly impair the biological properties of the antibodies, such as the paratope binding capacity (see, for example, Sciarra and Cutie, "Aerosols," in Remington's Pharmaceutical Sciences. 18th edition, 1990, pp 1694-1712; incorporated by reference). Those of skill in the art can readily determine the various parameters and conditions for producing antibody aerosols without resort to undue experimentation. When using antisense preparations of the invention, slow intravenous administration is preferred.

The compositions of the invention are administered in effective amounts. An "effective amount" is that amount of a cancer associated antigen composition that alone, or together with further doses, produces the desired response, e.g. increases an immune response to the cancer associated antigen. In the case of treating a particular disease or condition characterized by expression of one or more cancer associated antigens, such as breast, gastric or prostate cancers, the desired response is inhibiting the progression of the disease. This may involve only slowing the progression of the disease temporarily, although more preferably, it involves halting the progression of the disease permanently. This can be monitored by routine methods or can be monitored according to diagnostic methods of the invention discussed herein. The desired response to treatment of the disease or condition also can be delaying the onset or even preventing the onset of the disease or condition.

Such amounts will depend, of course, on the particular condition being treated, the severity of the condition, the individual patient parameters including age, physical condition, size and weight, the duration of the treatment, the nature of concurrent therapy (if any), the specific route of administration and like factors within the knowledge and expertise of the health practitioner. These factors are well known to those of ordinary skill in the art and can be addressed with no more than routine experimentation. It is generally preferred that a maximum dose of the individual components or combinations thereof be used, that is, the highest safe dose according to sound medical judgment. It will be understood by those of ordinary skill in the art, however, that a patient may insist upon a lower dose or tolerable dose for medical reasons, psychological reasons or for virtually any other reasons.

The pharmaceutical compositions used in the foregoing methods preferably are sterile and contain an effective amount of cancer associated antigen or nucleic acid encoding cancer associated antigen for producing the desired response in a unit of weight or volume suitable for administration to a patient. The response can, for example, be measured by determining the immune response following administration of the cancer associated antigen composition via a reporter system by measuring downstream effects such as gene expression, or by measuring the physiological effects of the cancer associated antigen composition, such as regression of a tumor or decrease of disease symptoms. Other assays will be known to one of ordinary skill in the art and can be employed for measuring the level of the response.

The doses of cancer associated antigen compositions (e.g., polypeptide, peptide, antibody, cell or nucleic acid) administered to a subject can be chosen in accordance with different parameters, in particular in accordance with the mode of administration used and the state of the subject. Other factors include the desired period of treatment. In the event that a response in a subject is insufficient at the initial doses applied, higher doses (or effectively higher doses by a different, more localized delivery route) may be employed to the extent that patient tolerance permits. In general, for treatments for eliciting or increasing an immune response, doses of cancer associated antigen are formulated and administered in doses between 1 ng and 1 mg, and preferably between 10 ng and 100 μg, according to any standard procedure in the art. Where nucleic acids encoding cancer associated antigen of variants thereof are employed, doses of between 1 ng and 0.1 mg generally will be formulated and administered according to standard procedures. Other protocols for the administration of cancer associated antigen compositions will be known to one of ordinary skill in the art, in which the dose amount, schedule of injections, sites of injections, mode of administration (e.g., intra-tumoral) and the like vary from the foregoing. Administration of cancer associated antigen compositions to mammals other than humans, e.g. for testing purposes or veterinary therapeutic purposes, is carried out under substantially the same conditions as described above.

When administered, the pharmaceutical compositions of the invention are applied in pharmaceutically-acceptable amounts and in pharmaceutically-acceptable preparations. The term "pharmaceutically acceptable" means a non-toxic material that does not interfere with the effectiveness of the biological activity of the active ingredients. Such preparations may routinely contain salts, buffering agents, preservatives, compatible carriers, and optionally other therapeutic agents. When used in medicine, the salts should be pharmaceutically acceptable, but non-pharmaceutically acceptable salts may conveniently be used to prepare pharmaceutically-acceptable salts thereof and are not excluded from the scope of the invention. Such pharmacologically and pharmaceutically-acceptable salts include, but are not limited to, those prepared from the following acids: hydrochloric, hydrobromic, sulfuric, nitric, phosphoric, maleic, acetic, salicylic, citric, formic, malonic, succinic, and the like. Also, pharmaceutically-acceptable salts can be prepared as alkaline metal or alkaline earth salts, such as sodium, potassium or calcium salts. A cancer associated antigen composition may be combined, if desired, with a pharmaceutically-acceptable carrier. The term "pharmaceutically-acceptable carrier" as used herein means one or more compatible solid or liquid fillers, diluents or encapsulating substances which are suitable for administration into a human. The term "carrier" denotes an organic or inorganic ingredient, natural or synthetic, with which the active ingredient is combined to facilitate the application. The components of the pharmaceutical compositions also are capable of being co-mingled with the molecules of the present invention, and with each other, in a manner such that there is no interaction which would substantially impair the desired pharmaceutical efficacy.

The pharmaceutical compositions may contain suitable buffering agents, including: acetic acid in a salt; citric acid in a salt; boric acid in a salt; and phosphoric acid in a salt.

The pharmaceutical compositions also may contain, optionally, suitable preservatives, such as: benzalkonium chloride; chlorobutanol; parabens and thimerosal.

The pharmaceutical compositions may conveniently be presented in unit dosage form and may be prepared by any of the methods well-known in the art of pharmacy. All methods include the step of bringing the active agent into association with a carrier which constitutes one or more accessory ingredients. In general, the compositions are prepared by uniformly and intimately bringing the active compound into association with a liquid carrier, a finely divided solid carrier, or both, and then, if necessary, shaping the product.

Compositions suitable for oral administration may be presented as discrete units, such as capsules, tablets, lozenges, each containing a predetermined amount of the active compound. Other compositions include suspensions in aqueous liquids or non-aqueous liquids such as a syrup, elixir or an emulsion.

Compositions suitable for parenteral administration conveniently comprise a sterile aqueous or non-aqueous preparation of cancer associated antigen polypeptides or nucleic acids, which is preferably isotonic with the blood of the recipient. This preparation may be formulated according to known methods using suitable dispersing or wetting agents and suspending agents. The sterile injectable preparation also may be a sterile injectable solution or suspension in a non-toxic parenterally-acceptable diluent or solvent, for example, as a solution in 1,3-butane diol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution, and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil may be employed including synthetic mono-or di-glycerides. In addition, fatty acids such as oleic acid may be used in the preparation of injectables. Carrier formulation suitable for oral, subcutaneous, intravenous, intramuscular, etc. administrations can be found in Remington 's Pharmaceutical Sciences, Mack Publishing Co., Easton, PA.

Examples

Example 1; SEREX screening of breast gastric and prostate cancer cells

Breast, gastric and prostate cancer cDNA libraries were established, using standard techniques, and the libraries were screened, using the SEREX methodology described by Sahin et al., Proc. Natl Acad. Sci. USA 92: 11810 (1995), and by Chen et al., Proc. Natl Acad. Sci. USA 94: 1914 (1997), each of which is incorporated by reference in its entirety. To be specific, total RNA was isolated by homogenizing tumor samples in 4M guanidinium thiocyanate/0.5% sodium N-lauryl sarcosine/25 mM EDTA followed by centrifugation in 5.7 M CsCl/25 mM sodium acetate/10 μM EDTA at 32,000 rpm. Total mRNA was removed by passing the sample over an oligo-dT cellulose column. The cDNA libraries were then constructed by taking 5 μg of mRNA, using standard methodologies to reverse transcribe the material. Breast cancer libraries were prepared from two different breast cancer patients, referred to as "MT" and "MK". Gastric cancer libraries were prepared from a gastric cancer patient, referred to as "YS".

The cDNA was used to construct a lambda phage library, and 500 phages were plated onto XLl-Blue MRF E. coli, and incubated for eight hours at 37°C. A nitrocellulose membrane was then placed on the plate, followed by overnight incubation. The membrane was then washed, four times, with Tris buffered saline (TBS) which contained 0.05% Tween, and was then immersed in TBS containing 5% non-fat dried milk. After one hour, the membrane was incubated with conjugates of peroxidase-goat anti human IgG specific for Fc portions of human antibodies (1 :2000, diluted in TBS with 1% BSA). The incubation was carried out for one hour, at room temperature, and the membrane was then washed three times with TBS. Those clones which produced antibodies were visualized with 0.06%

3,3'diaminobenzidine tetrachloride and 0.015% H₂O₂, in 50 mM Tris (pH 7.5). Any clones which produced immunoglobulin were marked, and then the membrane was washed, two further times, with TBS that contained 0.05% Tween, and then twice with "neat" TBS.

The membranes were then incubated in 1:100 diluted patient serum, overnight, at 4°C. The patient serum had been pretreated. Specifically, 5 ml samples were diluted to 10 ml with TBS containing 1% bovine serum albumin, and 0.02% Na₃N. The serum had been treated to remove antibodies to bacteriophage, by passing it through a 5 ml Sepharose column, to which a lysate of E. coli Y1090 had been attached, followed by passage over a second column which had E. coli lysate and lysate of E. coli infected with lambda bacteriophage. The screening was carried out five times. The samples were then diluted to 50 ml, and kept at -80°C, until used as described herein.

Following the overnight incubation with the membrane, the membrane was washed twice with TBS/0.05% Tween 20, and then once with TBS. A further incubation was carried out, using the protocols discussed supra, for the peroxidase labeled antibodies.

The positive clones were then sequenced, using standard techniques. Following comparison of the sequences to information available in data banks, clones were resolved into known and unknown genes. Some clones corresponded to previously identified human proteins and nucleotide sequences, and other clones have not been identified in humans previously, although there were related molecules found in other species. Still other clones represent molecules for which no related sequences were found (most clones contained very short sections (e.g. 25 or fewer nucleotides) that corresponded to portions of unrelated sequences). Some GenBank accession numbers representative of sequences having homology to the cancer associated antigen nucleotide sequences of the invention are presented in Table 1. All of the homologous sequences are accessible in publicly-available databases by reference to the sequences' accession numbers provided in Table 1.

Breast cancer clones:

The nucleotide sequences of clones derived from breast cancer patients "MT" and "MK" are presented as SEQ ID NOs: 1-205. Polypeptides encoded by open reading frames of the nucleic acid clones are presented as SEQ ID Nos: 594-829; the correspondence between nucleic acid molecules and encoded polypeptides is shown in Table 2.

Gastric cancer clones:

The nucleotide sequences of clones derived from gastric cancer patient "YS" are presented as SEQ ID NOs:206-352 (clones beginning with "YS"). Polypeptides encoded by open reading frames of the YS nucleic acid clones are presented as SEQ ID Nos: 830- 1083; the correspondence between nucleic acid molecules and encoded polypeptides is shown in Table 2.

Prostate cancer clones

The nucleotide sequences of clones derived from prostate cancer patient "ZH" are presented as SEQ ID NOs:353-593(clones beginning with "ZH"). Polypeptides encoded by open reading frames of the ZH nucleic acid clones are presented as SEQ ID Nόs.1084-1332; the correspondence between nucleic acid molecules and encoded polypeptides is shown in Table 2.

Table 1: Sequence homologies (GenBank Accession Numbers)

SEQ ID NO. 1

NGO-Br-38 combined

NM_006644.1 , AF039695.1, AB003334.1, AB003333.1, D86956.1, D67017.1, D67016.1, Z47807.1, NM_013559.1,

L40406.1, AB005282.1, AB005281.1, AB005280.1, AB023420.1, X67643.1, NM_008300.1, D85904.1, ACOl 1661.5, AE003611.1, AL109620.4, AC007049.8, AC005992.15, AC007066.4, AC006080.1 , AC009155.3, AF222716.1 ,

AC009223.2, AC004251.1, AC002367.1 , AL161553.2, AL161539.2, AL117202.1, AL009183.10, Z97336.1, AB006696.1, AI658961.1, AW571648.1, AW474070.1, AA843693.1, AW608075.1, AW470142.1, AW572452.1, AA543054.1, AW385582.1 , AI742981.1, AW612980.1 , AW612983.1 , AI582881.1, AI751853.1 , AI378269.1 , AI920808.1 , AI654608.1 , AI819251.1, AI831339.1, AI753470.1, AI312753.1, AI803588.1, AI563996.1, AA232636.1, AW015796.1 , AW1 17974.1, AI668853.1, AA535277.1, AA993280.1, AA632202.1, AA912023.1, AW627645.1, AW027050.1, AI337175.1, AI123280.1 , AA761750.1, AW316651.1 , AI223412.1, AW771160.1, AA219263.1, AW068948.1, AA482770.1, AA166716.1, AW236067.1, AA166806.1_> AA485151.1 , AI369932.1, AI250881.1, AA933881.1, AI262020.1, AI751852.1, AI050716.1, H52653.1, AI651186.1, AA678506.1, AA582157.1, AW628153.1, AI493255.1, AW340810.1, AI223825.1 , AW837156.1, AA136424.1, AA953645.1, AI582484.1, AI673134.1, AW820299.1, AA394027.1, T58153.1, T36072.1, AW390368.1, F22410.1, AA417317.1, AW020035.1, AA278231.1, AI361237.1, AI288972.1, AA810686.1, AW103624.1, AW604836.1 , AA730742.1 , AA082043.1 , Z20100.1 , D58216.1 , AI799265.1 , D29622.1 , AA435594.1 , AA233888.1 , AA485036.1, AI612928.1_> AI630481.1, F07487.1, AA731716.1 , AA417255.1, AA804371.1, AA571359.1, AA465183.1, F08794.1 , T34783.1, Z41841.1 , F03714.1 , AL137142.8, AC012569.3, AP001563.1 , AC022671.2, AC020999.4, ACOl 1743.3, AP000635.1, AP000610.2, AC008070.3, AC022797.3, AC005506.6, AL096782.3,

SEQ ID NO. 2

NGO-Br-39

MK262/T3 5'

AF039695.1, AB003334.1, D86956.1, NM_006644.1, AB003333.1 , NM_013559.1, D67016.1, L40406.1, Z47807.I , D67017.1, AB005277.1, AB005278.1 , NM_01 1020.1, U23921.1, D49482.1, AB001926.1, NM_014278.1, AB023421.1, L12723.1, AB005279.1, X67643.1, AB005280.1, AF077354.1 , NM_008300.1, AB023420.1, D85904.1, AB005281.1, AC024830.1, L08605.1, ACOl 1294.3, AC009424.2, AC022520.2, NM_013393.1 , AC019018.7, AF093415.1, AF161311.1, AF13671 1.1, AE001434.1, AE001433.1, Z49769.1, AC024813.1, AE003645.1, ACOl 1609.9, AC004150.8, AC004801.1, AL163244.2, AP001699.1, AP001605.1, L16771.1, AW820299.1, AW859988.1, AW859943.1, AW604836.1, AW820234.1, AW206874.1, AI094015.1, AA885873.1, AW820232.1, AI702970.1, AW390368.1 , AA777564.1, AA580595.1. H91160.1, AA777031.1, AW608075.1. H54657.1, H64019.1 , AI658961.1, H63551.1, AA811573.1, AW628153.1 , AA749004.1 , AI800379.1 , W45471.1, AI751852.1 , AW385582.1 , AI290252.1 , AW389335.1 , AA953645.1 , AW238563.1, AA805016.1, F08794.1, F07487.1, AW631423.1, T63090.1, N84915.1, AW630933.1, AW474070.I , AA166806.1 , N84914.1, AI758907.1, AW103624.1, AW571648.1, AA394027.I , AI002886.1, AA094644.1, AW391561.1, AW362751.1, H63595.1, AW609781.1 , H54656.1, AW572452.1, W86085.1, AW577563.1, AW820231.1 , AW362766.1, ^■AA555929.1_> AA555921.1, AA485036.1, AW820224.1, AW391572.1, H91211.1, AW316651.1, AI838486.1, AA571359.1, AJ397361.1 , AA334479.1, AW754210.1 , AW583074.1, AI760838.1, AW578928.1, AA212025.1, C81194.1, AA645750.1, AW819755.1, AW125594.1, AU080443.1, AA919208.1 , AA755774.1, AA615363.1, AA445826.1, AA117945.1, AI337175.1 , AW819997.1, AW470142.1, AA626524.1, AA079853.1 , W22433.1, T29047.1, AI626242.1, AW839103.1, AU035998.1, AA624532.1, AA572403.1 , AA431598.1, AA370218.1, AA571473.1, AW754207.1, AW366794.1, AL137142.8, AC015501.3, AC021286.3, AC006882.2, AC068895.1, AC055115.2, AC013660.4, AL354918.3, AL138763.2, AC010646.4, AC010267.5, AC008642.3, AC008484.3, AC006279.6, AC006278.6, AC016522.4, AC019327.4, AC021435.2, ACOl 1301.4, AF216669.1, AL159973.2, AL034557.7, SEQ ID NO. 3 NGO-Br-39 MK494 T3 5'

AF039695.1, AB003334.1, D86956.1 , Z47807.1 , NM_006644.1 , AB003333.1, NM_013559.1 , D670I6.1, L40406.1, D67017.1 , AB005277.1, AB005278.1, AB005276.1, NM_011020.1, U23921.1, D49482.1, AB001926.1, NM_014278.1, AB023421.1, L12723.1 , AB005279.1 , X67643.1, AF077354.1, NM_008300.1 , AB005275.1, AB023420.1, D85904.1, AC009424.2, NM_013393.1, AF093415.1, AC010852.5, AF161311.1, AF136711.1, AC005516.1, AE001434.1, AE001433.1 , AC003099.1, Z49769.1, AP001821.1, AC007678.3, AC006403.3, AC024813.1, AE003684.1, AC004668.1, AC004879.1, AC006354.2, AC010183.6, AC005049.2, AC004150.8, AC004801.1, AF049895.1, AF068862.1, AF004739.1 , AL16291 1.1, Z68341.1, AL032629.1, AL023578.1, U41009.1, L16771.1, AI094015.1 , AW206874.1, AA777564.1, AA885873.1, AI702970.1, AI800379.1, AA580595.1, AA805016.1, AW631423.1, AA811573.1 , AW630933.1. H91160.1 , AI290252.1, H54657.1, H64019.1, AI002886.1, N84915.1, W45471.1, H63551.1, H63595.1,

AW238563.1, H54656.1, AW577563.1 , N84914.1, AA094644.1, AA749004.1 , H91211.1, AI758907.1, AA777031.1, AA334479.1, AW604836.1, AW820299.1, AA580712.1, AW859988.1, AW859943.1, AW820232.1, AW820234.1 , AL042714.2, AW390368.1, AW391561.1, H64073.1, AW362751.1 , W86141.1, W86085.1, AA105012.1 , AW608075.1, AW389335.1, AW820231.1, AW362766.1 , AA555929.1 , AA555921.1, AI658961.1, AW820224.1, AW391572.1, AA714219.1, AA108277.1, AA580845.1, AJ397361.1, AW210124.1, AW754210.1, AW583074.1 , AI760838.1, AW578928.1, AA212025.1, AI656127.1, AW385582.1, AA645750.1 , AW819755.1, AW125594.1, AU080443.1, AA919208.1, AA755774.1, AA615363.1 , AA445826.1, AA117945.1, AI633338.1, AI203278.1 , AW819997.1 , AW628153.1 , AA626524.1 , W22433.1 , AI751852.1 , AA953645.1 , F08794.1 , F07487.1 , T63090.1 , T29047.1 , C81 194.1 , AW839103.1, AU035998.1, AA370218.1, AW754207.1, AI314009.1 , AW366794.1, AV162858.1, AI792084.1, AA909261.1, AL137142.8, AC015501.3, AC021286.3, AC069062.1, AC0241 12.9, AC008876.3, AL138763.2, AC010646.4, AC006278.6, AC016522.4, AC023956.2, AC005282.1, AP001863.1 , AL034557.7, AC023855.3, AC026995.2, AC018688.4, AC022758.3, AC013294.3, AC006876.1, AL1 17373.6, AL1 17335.19, AL157821.1, SEQ ID NO. 4 NGO-Br-55 MK225/T3 5'

NM_005716.1, AF089816.1, AF032120.1₎ AF089818.1, AF089817.1, AF104358.1 , AF061263.1, AL050318.12_> AC007678.3, AC012099.4, NM_004364.1, AC006019.2, AC007397.21 , AC007535.3, U51244.1, U34070.1, U94788.1, U92845.1, Z69303.1, Z95127.1, Z31375.1, X54156.1, X87248.1, Y11525.1, AP000559.1. M93344.1, AW732338.1,

AW409923.1, T25830.1, W06974.1, AW258706.1, AA396587.1, AA300306.1, AA839164.1, AF143339.1, AW416823.1, AI645842.1 , AA702414.1, AA259652.1, AA158704.1, AW316813.1, AW293608.1, AI989542.1, AI971171.1, AI903437.1, AI903333.1, AI903269.1, AI903268.1, AI810739.1, AI696771.1, AI669881.1, AU056473.1, AI508747.1, AI462731.1, AI4247I2.1, AI418022.1 , AI369600.1, AI335709.1, AI193578.1, AA974969.1, AA565967.1, AA513461.1, AA468577.1, AA396061.1, AA367767.1, W87364.1, N39553.1, H49150.1, H25130.1, R10174.1, T52003.1, AW795860.1 , AW594540.1 , AW514789.1, AW472932.1, AW359396.1, AW293828.1 , AW149413.1, AW064723.1, AW016496.1 , AW008028.1 , AI955331.1, AI697357.1, AI660572.1, AI565813.1, AI540768.1, AI538719.1, AI360009.1, AI126655.1, AI033638.1, AA515831.1 , AA503485.1 , AA496487.1 , AA428815.1, AA280408.1 , AA036554.1 , N67732.1 , N25184.1 , H03122.1 , T35597.1 , T16741.1, AC008569.5, AC022478.3, AL355872.2, AL162371.5, AL137781.3, AC010442.4, AC031984.2, AC060234.2, AC015958.3, AP000898.2, AP000919.2, AL121920.1 1, AL353195.1 ,

SEQ ID NO. 5 NGO-Br-55 MK225/T7 3' AF028824.1, NM_005716.1, AF089816.1, AEOOl 104.1 , AL096829.17, AJ007636.1, L38482.1, AC012467.9, AC007252.2, AC005757.1, AL049759.10, AB033031.1, AL033502.1, AF155065.1, AL138995.3, Z82214.23, AL031680.17, AJ222796.1, AW409924.1, AI720167.1, AI660895.1 , AI755163.1, AI472081.1, AA781474.1, AI073909.1, W73036.1, AI697434.1, AI887371.1, AI032395.1, AA581812.1, AA149940.1, AA535595.1, AI085734.1, AI951003.1, AA666165.1 , AI869948.1, AA579893.1, AI624402.1, R32110.1, AI241188.1, N64621.1, AA740666.1, AI589363.1, AW079516.1, AA677956.1, AW166984.1 , AI343472.1, AI831080.1, AW613269.1, AA878576.1, AI634734.1, AI955436.1, AI423229.1, AI683679.1, R50716.1, AA705739.1, AI690685.1 , AW050771.1 , H64249.1, AI867388.1, AW131086.1, AI654473.1, AI272198.1, AA325291.1, AI672928.1 , AW193998.1, R40181.1, AI886660.1, AA612759.1, AI867293.1, AI4991 13.1, AA404606.1, AI270050.1, AI056166.1, AA995431.1, AW664356.1, AI695629.1, AI289585.1, AI218312.1, T54484.1, AA918644.1, AI709119.1, R33590.1 , AI889242.1, R32109.1, AI804816.1, T30333.1, R09164.1, R77191.1, AA404222.1, AA304135.1, AW664565.1, AW664371.1, R33694.1, AA160211.1, AW439960.1, AA320369.1, AA135772.1,

AA135729.1, AI392813.1, AW190218.1, AI370449.1, W73301.1, AI298917.1 , AA160212.1, AA434159.1, T16203.1, AW752314.1, AI769156.1, AW338853.1, N78888.1 , AA295659.1, T48755.1, AI933841.1, AA887316.1, AW470194.1, N55776.1, AW007413.1, AC008569.5, AC010765.2, AL157781.1, AC007819.7, AL355350.2, AL161646.5, AL162454.2, AC051621.1, AC026055.3, AC013570.3, AC020565.4, AC023193.3, ACOl 1286.4, AP000846.1, AC053465.3, AC024715.3, AC023914.1, AC010729.3, AC010147.4, AL139253.1, AL031301.1,

SEQ ID NO. 6 NGO-Br-61

MK751/T3 5' AK001824.1, AK001625.1, AB020657.1, AK000931.1, AL137640.1, NM H6389.1, AF161553.1, AK001273.1,

NM_006469.1, AJ012449.1, AL031674.1, AC006928.15, AC006581.16, AC007436.1, AL049861.18, AC009303.2, AE003772.1, AC004843.1, AF003141.1 , U88180.1, AL034350.2, AP000606.1, AC006068.3, AC006031.2, AC006996.2, AC013417.4, AC005319.1 , AC003050.1, AJ009736.1, AC002065.1, Z69383.1, L14324.1, AP000185.1, AP000283.1, AP000109.1 , AI887429.1, Z42725.I , AA486796.1, AI697765.1, AI300924.1 , W31762.1, AA516054.1, H47565.1 , AI625041.1, AI498683.1, AA962704.1, AA581961.1, Z28830.1, AI621215.1, AI560075.1, AA603342.1, AA211203.1, AI453000.1, AA505767.1, H29506.1, AI493165.1, AW338106.1, AW271945.1, AI561182.1, AI357213.1, AA888065.1, AI950251.1, AA182641.1, AI750267.1, AW536810.1, AI893732.1, AA881079.1, AA833428.1, AA759435.1, AA274870.1, AA260237.1, AI564193.1 , AA172740.1, AA837350.1 , AA572435.I, AA290546.1, AA563475.1, AA622090.1, AW681468.1, AW261744.1, AA638984.1, AW107357.1, AW261646.1, AA170526.1, AA848235.1, AI873826.1, AI157598.1 , AI750915.1, AI596266.1, AI929865.1, AI790736.1, AI649320.1, AI043196.1, AL023060.1, AW630831.1, AI314622.1₎ AI314243.1, AI098095.1 , AI043182.1, AA5112I 1.1₎ AA434721.1, AAI40498.1, AA098508.1₁ R74754.1, AW532477.1, AI408553.1, AW750607.1, AV218438.1, AI048358.1, AA458054.1, AI763491.1, AV311575.1, AV005809.1, AA091451.1, D58165.1, AI911938.1, AI548180.1, AA086929.1 , AI581089.1, AW822437.1, AW208414.1, AW145984.1, AV159067.1, AI607800.1, AW535768.1, AW822436.1, AI182297.1, AA313132.1, AA799539.1, AI971805.1 , AV209231.1, AV207950.1 , AV154324.1 , AVI 18302.1, AV175071.1, AC016552.5, AC008499.4, AP001803.1, AP000479.2, AC027649.4, AC012429.4, AL353692.3, AC069214.1, AC024096.7, AC008670.3, AC067813.1, AC021601.3, AC023659.2, AC023818.2, AC009009.2, Z97201.7, AP001815.1, SEQ ID NO. 7 NGO-Br-61 MK751/T7 3'

AK001824.1, A 001625.1, AB020657.1 , AK000931.1, AL137640.1, NM_016389.1, AF161553.1, AK001273.1 , NM_006469.1, AJ012449.1, AL031674.1, AC006928.15, AC006581.16, AC007436.1, AL049861.18, AC009303.2, AE003772.1, AC004843.1, AF003141.1, U88180.1, AL034350.2, AP000606.1, AC006068.3, AC006031.2, AC006996.2, AC013417.4, AC005319.1, AC003050.1, AJ009736.1, AC002065.1, Z69383.1, L14324.1 , AP000185.1, AP000283.1, AP000109.1, AI887429.1, Z42725.1, AA486796.1 , AI697765.1, AI300924.1, W31762.1, AA516054.1, H47565.1, AI625041.1, AI498683.1 , AA962704.1, AA581961.1, Z28830.1, AI621215.1, AI560075.1 , AA603342.1, AA211203.1, AI453000.1, AA505767.1, H29506.1, AI493165.1, AW338106.1, AW271945.1, AI561182.1, AI357213.1, AA888065.1, AI950251.1, AA182641.1, AI750267.1 , AW536810.1, AI893732.1, AA881079.1, AA833428.1, AA759435.I , AA274870.1, AA260237.1 , AI564193.1, AA172740.1, AA837350.1, AA572435.1 , AA290546.1, AA563475.1, AA622090.1, AW681468.1, AW261744.1, AA638984.1, AW107357.1, AW261646.1, AA 170526.1 , AA848235.1, AI873826.1, AI157598.1, AI750915.1, AI596266.1, AI929865.1, AI790736.1, AI649320.1 , AI043196.1, AL023060.1 , AW630831.1, AI314622.1, AI314243.1, AI098095.1, AI043182.1, AA511211.1, AA434721.1, AA140498.1, AA098508.1, R74754.1 , AW532477.1, AI408553.1, AW750607.1, AV218438.1, AI048358.1, AA458054.1, AI763491.1, AV311575.1,

AV005809.1, AA091451.1, D58165.1, AI911938.1, AI548180.1, AA086929.1, AI581089.1, AW822437.1, AW208414.1, AW145984.1, AV159067.1, AI607800.1, AW535768.1, AW822436.1, AI182297.1, AA313132.1, AA799539.1, AI971805.1 , AV209231.1, AV207950.1, AV154324.1, AVI 18302.1, AV175071.1, AC016552.5, AC008499.4, AP001803.1, AP000479.2, AC027649.4, AC012429.4, AL353692.3, AC069214.1, AC024096.7, AC008670.3, AC067813.1 , AC021601.3, AC023659.2, AC023818.2, AC009009.2, Z97201.7, AP001815.1,

SEQ ID NO. 8

NGO-Br-57 combined;

AF025438.1, AL050353.1 , AL121924.12, U42838.1, AL031055.1, AE003680.1, AC005539.1, AL121931.10, AL139076.2, AL024458.1, AC004680.2, AC010889.2, NM_007050.2, AF043644.4, AE003844.1, AE003787.1, AE003676.1, AE003533.1, AE003519.1, AE003480.1, AE003422.1, AE003217.1, AE002799.1, AC004455.1, AC009320.7, AC007478.1, AC007123.1, AC005966.1, AC005548.1, AL163232.2, AC000389.1, AL035633.18, AL032654.1, Z68335.1, AL024473.1, Z92844.1, AL110503.1 , Yl 8930.1, AP001687.1 , AP001297.1, AP000459.3, AB005234.1, D17799.1, D17798.1, D17797.1, X79080.1, AB009052.1, AB006621.1, AA701988.1, AI337332.1, AI765742.1 , AI964006.1 , AI828070.1 , AI304319.1 , AI760923.1 , AA236789.1 , AW161742.1 , AI765022.1 , AI935340.1 , AW592648.1 , AA865602.1, AI765999.1 , N66532.1, AI631687.1, AA916723.1, AW161135.1 , W58718.1, AA236836.1. N32746.1 , AW051324.1, AA024685.1, AW152251.1, AW772254.1, AA916358.1, AA313566.1, AI336121.1, AA024784.1, AW614505.1, AI888263.1, N23163.1, AA007455.1 , AW272790.1, AI167263.1, AI283104.1, AA451907.1, AA995467.1, AI753758.1, AA505618.1, AI073755.1 , AA913049.1, AI538205.1, AA670386.1, AA007319.1, AI352390.1, AA680352.1, AW151295.1, AA720562.1, AI090162.1, AW466965.1, AA723980.1, AI808237.1, R72404.1, AI081040.1, AA992256.1 , AI267913.1,

AA541923.1, AA532854.1, R41738.1 , AA236656.1 , AA928158.1, AW117185.1, AI630438.1, AA016221.1, AA345744.1, AA 137279.1 , R72405.1, AI140745.1, AI084344.1, AI079153.1, AA852227.1, AA852226.1 , H89982.1 , AA000683.1, AI539552.1, AA385531.1, AW427494.1, AW557853.1, N50079.1, AI461713.1, AA858049.1, AW536613.1, AI599140.1, W10638.1 , AI678339.1, AA637410.1, H30501.1, AW172462.1, R17187.1, AI630424.1 , AI678340.1 , R77800.1, W43974.1, AI198148.1, N56244.1, AW433804.1, AI841918.1, H25699.1, AA003291.1, AL136131.7, AL355349.1, AL138706.1, AL050335.24, AC016073.2, AC023651.2, AL354992.1, AC026285.4, AC055116.2, AC012133.3, AC006756.1, AC012031.7, AC007953.7, AC027502.3, AC026747.3, AC008821.4, AC016635.4, AC008926.5, AC008924.3, AC008592.3, AC009679.3, ACOl 1639.6, AC016824.4, AC013237.1, AL356427.1, AL138899.6, AL160276.2, AP000841.1. AP000783.1,

SEQ ID NO:9

D26077, AJ009839, U00996, AF035621, AJ002223, AF013116, X57435, AF134401.1, AC004653, AL024473, AC004741, AC004453, AL023806, U36562, U64849, AF016450, AC003689, Z77652, AJ223630, AF026029, M76713, AC006525, Z70687, AL034351, Z94054, AC005955, U91325, AF051917, D90054, AF039047, AC003024, U23168, X89969, U21317, W75604, W88219, AI390662, AA107502, AA959827, AA562519, AA139695, AI505854, C80964, AI646091.1, AA217408, AU017533, W44823, AA381672, AI492198, AI185648, AI630930.1, T86437, AA558491, AA216567, AA368001, AA827488, AA425663, N84321 , AA040741 , AA084287, AA339843, AI524007.1, N73729, N75454, AA025609, AI244351 , AA489142, AI283076, W05252, T98110, AI244357, AA659485, AI266380, AA972439, AI659137.1, D36418, AI065185, C67420, AA116198, AU000875, N98152, C56081, AU039284.1, AU039994.1, AA948761, AI162556, C55758, AA406665, AI305146, AI368299, D39322, AI588173.1, AU001015, A56778.1, 132847, A56776.1, 132846, 114753, A69720.1, 132959, 127064, 103683, 108248, E00136, 122490, A 18007.1 , 108585, A13479.1, 100031 , 171463, A51384.1, 171462, 121102, 196207, 149950 SEQ ID NO: 10

AC005480.3, AC005031, AP000134.1, U80017, AL03131 1 , AL022728, AC005777, AF037338, AC006163, AC005409.1, AJ003147, AC002476, AL022718, AL022323.7, AC004983, AC003085, AL022398, Z83841 , AF 134726.1, AC005534.2, AC005532, AC005913, AC005828, AJ131757, AC002491, AC004150.8, AC000075, AC006511.5, AC000084, AC002430, AC005231.2, AC003663, AC003108, AC005666, Z79996, X54156, AC004884, AL008583, AC004791 , U94788, AC000092, AC004982, AL035419.9, Z73967, AC002347, AC002990, AP000111.1, AC004686, AC004891, AC002477, AC004590, AC000086, AF039905, AL031286, Z81364, AC003070, AF001551, Z81365, AE000659, AB018295, AC006561.8, AC006327.3, AC005622, AC005214, Z54246, AC002350, AC004797, AC005620, AC005212, AC005844.7, U85199, AC005664, AC006547.9, AC002519, AC002404, M34061, Z68330, U92009, AL021397, M63544, AC003664, AL033524.11, D83402, AC004017, U48471, Z82174, AC005663, AC004785, AC000090, AL031407.3, Z96074.4, AC005006, AC005531, AC004960, X71401, AL030995, Z97989, AC005581, M63543, AA501297, AU018489,

AU019533, AI413126, AI413410, AI503861, AA501217, W51648, AA516955, AA518598, W64166, AA823826, C88193, AI174175, W61986, AI326216, C88111, AU043112, AA863851, W62377, AI430519, AI616330.1 , C87922, AA501128, AA516629, AA517646, C86532, AA501262, C87864, AI272569, AAl 1 1730, AI425687, AI042721, AI562135.1, W64884, W77222, AA462890, AA797781, AV031046.1, AA40981 1, AI550652.1, W99885, AAl 16963, AA544786, AI649198.1, AA097669, AA261001, AA542366, AI413859, AI324947, W70990, AA265787, AA967965, AA986868, AI647722.1 ,

AI646106.1, AA517461 , AI648046.1, AI464652, AA217355, AA242458, AI507213, AI6481 10.1, AI648128.1, AA183349, AA122689, AA734912, AA832680, AI325146, AAl 19201 , AI573919.1, AA881598, AA986420, AA671469, AI666716.1, AA867613, AI326422, AA881230, W18241, AA087547, AA915562, AA709758, AA217782, AA657012, C87438, AI642202.1, W62449, AA959963, AA763337, AI286582, AA509536, AI593871.1, AI605818.1, AA204228, AU051781, C79973, AA467249, AA398732, W38434, AA393394, AI358870, AA679523, AA345329, AI096496, AI049868, AI159851, AA623010, AA815038, AI380153.1, AI282253, AA533025, AI589942.1, C14022, AA598954, T15722, AA302658, F04710, W45306, AA322586, F04545, R36507, AI368853, AA663373, AA079076, AI431513.1, AA223512, AI310992, AI300818, AA599074, W63553, AA573000, H86579, AA018923, AA344768, AI583291.1, AA012829, T50676, AA808036, AI368732, H86221, AA019003, H84412, AI366180, AA768179, AA211734, AA244181, AA714073, AI309121, AI343669, A A503018, N52293, AI591 134.1 , F35684.1 , AI284543, AA748102, AI434365.1 , AI251034,

AI251203, T53829, AI251284, AI254770, AI250552, AI054090, AA587826, AI246061, AI251944, AA573062, H40478, T62078, AI620992.1 , AA640310, AA633907, AA846923, AA642809, AI185394, AA378489, AI609972.1, T54783, AA053463, AA741301, AI049630, AI537800.1, AA180775, H79453, H99700, AA632556, AI267356, AI306717, AA766414, AI002762, AI628859.1, AI417586.1, AI635196.1, AI267450, R37503, R71796, AA318116, AA550283, AI539956, AI066909, AI044039, AI145414, AI218793, H39328, W06387, H39389, AA107123, AI209314, AI151560, W06750, Z69957, AI385339, AI145871 , AA849983, AI407780, D86779, AU057675.1, H39426, AI556681.1, AI549274, AI236139, AI385214, AI231550, AA859752, AA979650, AI408895, AI170305, AI172328, AI410991, AI519994,. AI230468, AI575399.1, AI575403.1, H39351, AI599192.1 , AI013893, AA900554, AA955084, AI603163.1, C21900, AA850419, AI077076, AI411474, AI044422, D86656, AA899103, AI576270.1, AI489703.1, D48840, AI169234, AI163194, AI166186, AI031502, AA799804, 134294, 176960, 140904, 140899, A47886.1, E12183, A62791.1, A51133.1, 196203, A26415.1, A65890.1, A51135.1, 105724, E03829, A47885.1, A28928.1, 162750, AR009805, 173182, AR014241, 173181, 159642, A67988.1 , 155948, 173246, A37262.1, 174786, 196182, A52294.1, A28005.1, AROOOl 13, E02192, A64529.1, A64531.1, A64510.1, 138891, 109380, 115767, 145974, 109337, 1081 10, E12647, AR002329, 125849, A70693.1 , A19048.1, 108174, A22938.1, 134189, 102857, AR007159, AR007160, A67424.1, AR008154, 115157, AR007118, 143096, 143100, AR003505, AR016442, E03351, 176959, 136306, 123499, 118513, A58551.1, 141411 , 116884, A43445.1, 107993, 105479, 189273, E02252, E12964, A69986.1, 125678, 140313, E00140, A51134.1 , 131097, 108711, 108101, E01888, E02193, AR014384, A63257.1, AR020909, 147706, 193602, A63032.1, 117548, 196204, 108362, 117291, 101147, 102155, 141409, AR016729, 192783, AR009214 SEQ ID NO: 11

AF021800, U10118, Z97198, Y08737, Y14947, Z60673, AL035610.2, X61295, AE000014, AC003018, AF037352, AC004412.3, AE000663, AC003063.7, M33312, L24192, AL032632, AC005403, M97517, AC003997, AB020742, X79073, AC003003, U21321, AC002181, X03095, AC004040, U80439, AE000664, AJ011763, AB002334, M84723, Z74161 , U40941, AC006031 , Z49809, AF041853, AC004237, Z70753, Y14278, AJ002005, Z49349, L26923, AI594998.1, AA981629, AA242568, AI429115, AA218315, W75795, W30441, W75249, AA420074, AA798327, AA268851, AU020128, AA435309, AU020212, AI413768, AA031103, W20836, AA048923, AA003813, AA792199, W61728, AA0I4265, AA041914, AA771453, W77239, AA541822, W85151 , AA537559, AA155051, AAl 14709, AA260917, W85306, AA386560, AA718522, AA386635, AA511 139, AA71 1462, AAl 17872, AA930871, AI122171, W75273, AA138243, AA645328, AA120159, C79417, AA709995, Wl 1155, AA068190, D21672, AA289897, W82402, AA881775, AA711586, AV042196.2, AI18241 1, AV032023.1, W90821, AA683870, AA718618, AV017909.1, AA065744, D18760, AA692504, AV031977.1, AA064500, AA073543, AA880781, AAl 18315, AI530605, AU044216, AA770994, AU045821, AI591467.1, AI587681.1, AU045216, AU044215, AA727390, AI587682.1, AA770995, AA204486, AA796217, AA716965, AA475324, AI019643, AU023053, AA710660, AA738810, AI324709, AA209984, AA183519, AA068031, AI052246, AI559461.1, AA622031, AI332648, AA435714, AI492363.1 , AA938590, AI092238, AI188366, AA778542, AA455908, AI671681.1 , AA582508, AA587478, AA397977, AA455165, AA456533, AI479525.1, AA456374, AI652563.1, AI589034.1, AA810612, AA188088, AA503544, AI458348.1 , AA528698, AI192386, AA566076, AI431854.1, AA862906, H43129, H05377, All 30824, N40728, AI344800.1, N45576, C03104, AA352178, C03071 , AI392944.1, N48785, AA534079, AA657749, W25040, AA421615, R62721, N50217, D19778, F22451.1, AI308003.1 , AA204880, AA766513, AA204910, AA643643, AA621853, AA911790, AA724841, AI624242.1, R60744, AI500610.1, AI203401, W56275, AI638598.1, N63111, H49985, AI373287, AI191588, AI246039, AI381317, AA923262, AA874975, AI136838, AI454911, AI501868, H32629, AI330441, C23456, C06649, AI161984, D68580, AI177458, AI031457, T14012, AI044756, AA94451 1, C70166, R90369, AI072460, H35675, T41601, AA955213, AA550022, AA684830, AA686173, AI236174, 150092, AR024452, 147299, A09007.1, A47883.1, 128198, A47885.1, AR024451, AR024454

SEQ ID NO: 12

AJ006972.1, Z82097, AL008635, AC005290.3, Z82244, Y08741, Y08742, AF010146, M63544, M63480, M63005, L291 10, L26978, D25535, L26977, AB008180, AB008179, AB008178, AB011171, AB008181, AC005011.2, D86916, U73647, AB008182, AB019435.1, D86993, D86917, AC003969, AA692113, AA760311, AA624213, AI316565, AA163340, AA510098, AA572533, AI120898, AA410059, AI172900, AI323328, AA601526, W03454, C18051, T08420, H07047, AA314313, R60279, H56574, R13875, AI271346, R35102, H55150, R69765, H55342, AA780138, T06093, AA199876, AA207191, AA101324, AA279681, T52837, N89391, AI367591 , F32515.1, R68384, AI149946, AI568596.1, AA725526, AI298130, AA291106, T10439, C16975, AA367318, AI348687, C19853, AI575790.1, AU003722, AU003832, H98311, 173389, 189388, A37795.1, E07536, 138852, 122507, 122508, 156094, 164893, 118362, AR009723, 108490, 105217, A33685.1, A12612.1, E12656, A70367.1, 195876

SEQ ID NO: 13

U58970, Z93929.1 , AF114171.1, Z81360, AE001061, AL034562.2, AC004668, AF032734, AF010317, AC006054.2,

U08008, U23528, AA068863, AA008160, AA530777, AI325688, AI595520.1, AU035402, AA692569, AA061860, W64597, AI035386, AA065497, AA250161, AA036616, AA896677, AA467612, AA008414, W71676, AA414908,

AA636533, AA466691, AI426325, AA681340, AI429169, AI006006, AI482274, AU022840, AI604817.1, AA930480, AA726296, AI151985, W12938, W54805, AA220608, AA222025, AA269546, AA038987, AU040427, AU044915, AI596350.1, AA563232, AA796461, W65676, AA423540, AA073134, AA198543, AA222283, AA259525, AA469501, All 16855, W65005, AI173742, AA874364, AI060876, AA739143, AV016603.1, W58939, AA153672, AAl 17468, W87996, AA537500, AI046820, AA017847, AI046923, AA647458, AA671738, AU015869, AI019252, AU016054,

AV014010.1 , AA541869, W82499, AA544042, AA793278, AA756503, AA793893, AI130910, AI086610, AA743858, AI290656, AA131037, AI125470, AA745976, AA642908, AA457118, AA514531 , W47335, AA976199, AI005635, AI310405, AI138393, AI601 160.1, AI188148, AA464084, AI459399, AA129925, AI268706, AI201 189, AI038340, W47460, AA131101, AA641641, AI138278, AA130705, AI567286.1, AA285110, AI208543, W16633, AA454154, AA653333, R74396, AA932373, AA588644, R83918, AA292686, AA759367, H75519, R83919, D59308, H03960,

H68335, H79937, Z25102, AA678931 , AI025455, AA641226, AI247227, AA729009, AA285013, H03153, AA887404, AA781833, AA463949, H48272, AA514341 , AA236001, R39018, AI041647, T80448, AI208401, H68336, T83268, F05747, R57935, N78749, AA327260, AA761636, AA369899, AA129924, AI220922, T51048, H75520, T90735, AA319356, AA093579, AA916614, AI525914, AI381199, N93795, D78669, AA290835, AI538282.1, AA662813, AA866145, AA064634, AA064700, T50985, H06928, AI375083, AA478496, AA322521 , H35684, AA686648, AA686425, AI412736, AI231571, AI602225.1, AA819360, AA893327, AA754214, AI007683, AI101399, AI144679, AA963591, AI145971, AI555474.1, AA818417, AI008572, AI548931, AI145660, AI145729, AI070870, AI145465, AI577487.1, 117131, 1711 14, A43751.1, 148921, 117132, 115471, 1711 15, 115472, 149533, 115009, A27345.1, E02290, A33017.1 , 115010, 115001, E05947

SEQ ID NO. 14

NGO-Br-60

MK746/T3 5'

NM_003311.1, AF035444.1, AF001294.1 , AF019953.1, AC005950.1, AC001228.1 , NM_009434.1 , AF002708.1, Y15443.1, NM_009344.1, U44088.1, AF192802.1, AF022148.1, U43930.1, U13369.1, M25718.1, AE001938.1,

AJ006099.1 , AD000014.1, X17403.1 , Z84724.1, Z98260.1, U13701.1, M17225.1, M60560.1, AF239986.1, AF145729.1, NM_007350.1, AC005836.2, AC004145.3, NM_007730.1 , AE001881.1, AF1951 15.1 , AC005060.2, U67167.1, AC004221.1, U92983.1 , U67505.1 , AF031880.1 , AF013293.1 , AL161472.2, AL161471.2, AL031722.18, U25652.1 , L22760.1 , X82678.1, Z50194.1 , A O01817.1, D49955.1, M25638.1, M13016.1, AI7681 17.1, AI290356.1, AWO44158.1, AW084115.1, AW015740.1, AI740612.1 , AI742439.1, AI073833.1, AI452633.1, AI863726.1, AI188588.1, AI309294.1, AI741269.1, AI337297.1, AA479005.1, AI832162.1, AI741008.1, AI077667.1, AI129104.1, AI738908.1, AI766545.1, AI277523.1, AA814143.1 , R75643.1, H68978.1, AI565240.1, AA693763.1, AW084562.1 , AI991120.1, AI689894.1 , AI492135.1 , AI281966.1, AI200143.1 , R75749.1, AW465323.1, AW463580.1 , AI669214.1, AI298392.1, AW466053.1, H68885.1, AI222900.1, AI422619.1, AA503237.1, AA989208.1, AW464723.1, AA057186.1, R68174.1, AI802724.1, AA968817.1, AA502313.1, AI306416.1, AI802743.1, N29541.1, AA577052.1, AI253677.1, AA291981.1, AA976627.1, AI991092.1, W30881.1, AA369394.1, T35140.1, T35135.1, AAl 13149.1, T35134.1, AA976558.1, AA293320.1, AA477941.1, AW544694.1, AW544396.1, AW544044.1, AW543513.1, AW543163.1 , AW537922.1, AA409046.1, AA407959.1 , AA153169.1, AA161891.1, W74902.1, AI029402.1, R24092.1 , AA409059.1 , AA056958.1, AA876081.1, AW545407.1, D20894.1 , AW538590.1, AA944922.1, AA014727.1, AI400179.1, AW765596.1, AI123706.1, AA407958.1, AW761915.1, AI849120.1, AI840385.1, AA989987.1, AA596171.1 , AI704218.1, AA965045.1 , AC013791.3, AC021544.4, AC023248.2, AC068006.1 , AC069236.1 , AC068881.1, AC068192.1, AC023572.3, AC026915.1 , AC016174.4, AC025630.1, AC010554.1, ACOl 1630.2, AL353644.2, AL355134.1, AL158197.6, AC008891.6, AC024594.3, AL133293.18, ACOl 161 1.9, ACOl 1699.5, AC025913.2, AC015890.2, AC021218.3, AC016049.2, AC021675.3, AC021528.2, AC012284.2, AC009887.4, AC024199.1, ACOl 1699.4, ACOl 1129.3, AL356072.2, AL160282.3, AL355001.3, AL096855.24, AL354808.3, AL132867.12,

SEQ ID NO.15 NGO-Br-60 MK746/T7 3'

AJ004801.1, M84465.1, M61143.1, AE003791.1, AE003450.1, AC006036.3, AC000093.3, Z82188.2, AL135745.2, M31646.1, M34193.1 , Z85989.1, AI279567.1, AI125808.1, AI743388.1, AI554623.1, AI336185.1, AI768190.1, AI394538.1, AI356687.1, AI279283.1, AA524259.1 , AI140335.1, AI125797.1, AI858974.1, AI093933.1, AI272028.1, AI268851.1, AI042070.1, AA568684.1, AI338345.1, AW770516.1, AA776787.1 , AA482453.1, AI191334.1, AI813413.1, AI352347.1 , AI042254.1 , AI268758.1 , AA532627.1 , N68172.1 , Al 160353.1 , AA931805.1 , AI343021.1 , N68196.1 ,

AI077948.1, AA705334.1, AW327781.1, AI198251.1 , AA721003.1, W05193.1, AI830795.1, AA481706.1, AA715390.1_> W58698.1, AA417821.1, N68260.1 , W58215.1₎ AW439353.1 ₎ W69215.1, AI281960.1, AI800014.1, N89605.1, AW071418.1, AW517028.1, AI298093.1, AW149380.1, AI369601.1, AI191106.1, N54740.1, AA428492.1, AI074994.1, AA976989.1, AA057072.1, AA976789.1, H19993.1, H02830.1, AI298398.1, W58699.1, R69545.1, H27894.1, T35392.1, AI370680.1, AI206775.1, H20384.1, AI261835.1, AA603925.1, H83921.1, H50256.1, AA740592.1, R62272.1, W07471.1, AA471035.1, AA328860.1 , R69416.1, AI184456.1 , R96832.1, AW000778.1, AI207043.1, W58105.1, W80558.1, AA522968.1, N75444.1, AW291022.1, H63728.1, H20193.1 , AA887675.1, AA853980.1, AA771899.1, D25746.1, AA976567.1, W80428.1, ALl 36379.2, AC026443.2, AC008961.4, AC051636.1, AC024447.2, AC026065.3, AC026270.2, AC025804.2, AC022953.2, AC013624.4, AC022315.5, AC009218.6, AC016019.3, AC022030.1, AC0I4982.1, AC020202.1, AC0O7837.3, AC007913.1, AL158151.5, AL161785.4, AP001120.1 , AP000405.2,

SEQ ID NO.16 NGO-BΓ-68 MK442 T3 5' AF141968.1, AB033077.1, AB029290.1, AF150755.1, U67205.1, U67204.1, U67203.1, NM_016615.1, U76343.2,

NM_003263.1 , U88540.1, AL161557.2, AL009028.1, D13637.1, AL021635.1, AI734450.1, AW865983.1, AW531012.1, AW405405.1, AW148645.1, AI583168.1, AI290663.1, AA451993.1 , AA302993.1, AA297912.1, AA288614.1 , AA178091.1 , R78273.1, AW816433.1, AW816426.1, AW290918.1, AL133903.1, AV221162.1, AI504039.1, AI403713.1, AI238618.1, H23080.1 , AL356055.1, AC019071.3, AC061993.2, AC06891 1.1, AC025594.3, AC009546.3, AC010537.2, AC010687.2, AC010090.3, AC004229.1, AL354956.1, AL162405.2, AP001098.2,

SEQ ID NO.17 NGO-Br-68 M 442/T7 3' AF141968.1, AB033077.1, AB029290.1, AF150755.1, U67205.1, U67204.1, U67203.1, AC006299.1, AE003771.1, AC005670.1, AJ277889.1, AL121988.10, AC00011 1.1, AL031599.1, U27560.1, Z99112.1, L08471.1, AC0O9415.2, AE003507.1, AC006971.2, AL163258.2, AL135879.1 , AL121790.2, AL139074.2, Z35640.1, AJ248288.1, U51998.1, AP001713.1, AP000178.1, AP000034.1, AP000266.1, AP000102.1, AC009236.4, NM_014514.1, AF105235.1, AF104852.1, AE003845.1 , AC005137.1, NM_004857.1, NM_003672.1, AF165124.1, AF103013.1, AF103011.1, AF103010.1, U73396.1, AF071085.1 , AF022044.1, AF001881.1, AF000367.1, AL132773.14, AL132793.24, AL162691.1, AL049588.11 , U30274.1 , AL035475.6, L76664.1 , L76661.1, L41269.1 , X97232.1 , X97233.1 , X94262.1 , 90359.1 , AB013389.1, AB010073.1, Z99120.1, Z21839.1, AA418046.1, C43219.1, AW565904.1, AW287353.2, AW285203.1, AW283675.1 , AI948261.1, AV165647.1, AA393617.1, Z29935.1, AC068280.2, AC009416.2, AC008414.1, AC013858.1 , AC007893.6, AC007892.3, AL121993.6, AL122010.2, APOO 1002.1 , AC055822.2, AC068120.2, AC020995.2, AC0361 18.2, AC068104.1, AC025117.2, AC027113.2, AC067758.1, AC018587.3, AC012693.1, AC007513.13, AC021104.2, AC06892I.2, AC068883.1, AC025459.3, AC008684.4, AC026178.2, AC060785.1, AC053491.1, AC041008.1, AC034223.1, AC008706.2, AC027134.1, AC019101.3, AC026193.1, AC026187.1, AC026171.1 , AC021696.3, AC015611.3, AC021556.3, AC021287.4, AC018810.2, AC015475.3, AC017113.3, AC019027.2, AC015011.1, AC010073.1, AL139137.2, AL163543.2, AL122035.2, AL158038.2,

SEQ ID NO: 18

M90814, M86183, D16309, U82832, M88085, M88086, M90815, U43844, U49935, M88087, U47285, M88084, S78355, M64403, 73554, M74092, Z23022, X59798, L09752, D14014, X75207, D16308, M90813, X68452, X89475, U28980, M88081, X87581, M83749, M86182, U87099, M91003, U40844, Y10075, X89476, AF037570, X83503, U79301 , AJ236635, U14950, U93309, AF010496, AC004530, AF085248, S54563, L48803, AF017112, U16789, AF109069, Y17214, AI322454, AA051245, AI122217, AAl 18092, AA597177, W97516, W40624, W63869, AI097883, W34342, AA199092, AAl 17687, W65166, AA797053, W10608, AA033206, AA062207, AA796967, AA793825, AA000419, AA028593, AA014268, AA033005, W48284, AA881788, AA771036, AA796947, AA670841, AA008831, AA271986, AA002975, AAl 11431, W59174, AA396492, AA727608, W61835, AA591 109, AA797087, AA062020, AA499515, AA210201, AA123883, AA914952, AA682134, AI323180, AI325829, W79998, AA881818, AA657272, AI324083, AAl 11722, AI528899, AA711810, AA269978, AA060924, AA060518, W53383, AA105418, W71681, W53854, AA930561, AAl 16586, AA034898, W54260, C81477, W82409, AA124938, C79771, AA560551, AI323871, AA269913, W09396, AI503391 , AA467356, AI322927, AA396728, AA153736, AA472900, AA512802, W90890, AA733955, AA682053, AI181456, W08991, AA002467, AI426307, C78795, AA140358, C81516, W10677, C80994, AV012985.1, W98440, W97358, AA726582, AA655786, W75724, AA646393, AI592902.1, AA276376, AI356287, AI436372.1, AA634212, AI452828.1, AI276632, AA975277, AI371720, AI080403, AI399960.1, AA478420, AA278460, AI287846, AI362073, AI347606, AI363127, AI279553, AA443513, AI130809, AA402345, AI365032, W31908, AA480461, AA398785, AI143359, AA9881 18, AI648542.1 , AA195505, H89623, AI567387.1, R70362, AA195376, AI383816.1, N94440, W39271 , H89477, AA506987, W24758, AA428380, W02748, T27682, AA400851 , N32310, N57406, AA380350, C00443, W94407, D58595, AA361389, W21508, AI475678, AA380681, F28617.1, R70363, AI270923, AI340905, N93040, AI251663, AA334005, AI336519, AI254005, F20264.1, AI312391, F37177.1, AI31 1447, AI311448, AA160146, AA335701, AA283255, W30788, AA160147, AA165301, N36623, W94406, AA226806, AA100854, U47703, AA866574, AI086542, AI278890, AI190622, AI382164.1, AI499061.1, AI347077, AA402387, AI085348, AI568929.1, W60380, AI274886, AI183918, AI571777.1, AI023701, AAl 12340, AA126942, AA227161, AA906539, N75459, W60289, AA160820, R91955, AI230696, AI408565, AA900873, AI100977, AI175996, AI104322, AI013336, AA850467, AI231788, AI236125, AI171927, AA891743, AA958014, AA955666, AI228950, AA957218, AI011931, AI030214, AI407630, T15257, AI177145, H34217, C06758, AA519689, AA851383, All 14164, AI045153, AU010436, AI487549.1, AI238469, 196214, 123762, E03080, 175252, 134034, A27260.1, 141421, 134031, 175356, 175254, AR014269, AR014271 , AR014272, 173180, A67848.1, 125678, 116616, 173182, AR014270, 141349, AR014241 , A09995.1, AR014273, A26437.1, 120505

SEQ ID NO: 19

AF035950, AF035620, AC002126, X78504, AC004014, X82039, AB015469, X89558, AF083424, AC004617, Z82189, AC007055.3, AC005247, X89535, AC006530.4, AF083069, AA792693, AA726783, AA771149, AA518210, W14021, AI390859, AA342139, AA877660, AA828666, T87569, W60401, AI640567.1, F30242.1, AA862855, AA995857, AA669837.1, AI242161 , AA743161, AI340251, F22148.1, AI632625.1, AI151418, AI637787.1, AI608941.1, AA186698, AI075293, AA173985, AI2921 10, AI373314, AA100913, AA522692, AI590809.1, AI524808.1, AA295949, AA182705, AA160675, W46673, AI650925.1, Z43839, AI332985, AA995455, AA129593, F26241.1, AI272109, W60310, AI347479, AI080003, AA834774, AA694518, AI346936, W42415, N49848, AA001202, AA773564, AA031697, AI659936.1,

AI640340.1, AA129330, H66266, AA817737, AA841970, E02685, 146903, E02810, A70722.1, A58497.1, A58525.1, A58521.1 , A58526.1, AR009500, A58523.1 , A70697.1, A58522.1, A58498.1, A58524.1 , 136936, AR013983, E12486, A68194.1, 150036, 113539, 150038, E12631, A63583.1, A39440.1 SEQ ID NO:20

D83260, X87199, D83261, L44140.1, X7461 1.1, D83388, D83389, AF012071, Z66565, AC004736, U78310, AF009620, AC005006, AF102139.1, X98173, X98177, M96823, X98172, U58143, X98178, X98176, M14220, AF110004, AL031640.1, D10667, AC005831, AC005887, AB020673, L27155, AB023482.1, M69181, U31463, X13586, L09104, M77482, L16993, AF001548, AI510573, AA145965, AI155964, AA492660, AU035834, AA060937, AA265452, AA171056, AI326531, AA435069, AA512465, W14241, AA102994, AA062157, AI315360, AA183741, AI036559,

AA409062, AA473920, AA260266, AA434684, AA389221, AA797841, AA919576, AI528817.1, AI036001, AA027647, AA165848, AA683821, AU041887, AI390165, AI152568, AI605728.1, AI122032, AV045840.2, AI195545, AA000224, AA389213, AI255740, W18089, AA619651, W64485, W87140, AA060933, AA241200, AA445791, C77979, AI664303.1, W85405, AU041902, AA510701, AV044861.2, AA000159, W07980, AA157345, AA083878, AA053735, AA312864, T62991, AA374540, AA969971, AA370067, AA584930, AA584911, T75223, AA573791, AA595492, AI207763,

AA043275, AA629772, AA907439, R32740, AI625774.1 , AA312258, AAl 28875, AI245951, AA092288, AA482992, T07180, AA306254, F08778, AA491093, AAl 14049, T74054, AA206475, T16890, R73497, R51754, AA426585, AA888565, AA984237, AA412321 , AA664001, R55849, AA214456, W46645, AI572049.1, AA074593, AA176605, AA412665, AI354431, AI268841, AI437247, C71174, C91867, C91635, AI01 1621, AA390379, Z47662, AI516015, AA686693, AI231448, AA201957, AI235217, AI258748, AI408532, AI294149, AI104095, AA950318, T82761, M79660, C50053, AU064512.1, AI238267, AI178066, C97290, D74869, AU057911.1, AI295595, AI658254.1, AI063708, AI296592, AI477740, C20354, C41837, AU029982, AI404208, C44430, AI514088, R89934, AI107270, AA202366, AI295756, AU054048.1, AU057892.1, D75473, C43065, AI403994, All 14383, AI106670, 182207, E06625, E04317, 182202, 164540, 108607, 166263, E06231, A58497.1 , E06246, E06232, E06233, 115824, A58522.1, 115975, AR007585, E06234, A58521.1, E06226, AR007590, A62340.1, E06261, E06235, E06248, A58523.1, E06247, A58498.1, A46716.1, A58526.1 , 196211, A64582.1, 101254, A25492.1, E05192, 168138, A09962.1, 130482, E04845, 101251, 101212, A15671.1, A20861.1, 121938, E00989, A39477.1, A20359.1, A52091.1, E00359, E08423, A39482.1 , 101215

SEQ ID NO:21 D83260, L44140.1, D83389, X87199, X74611.1, AC006264.2, Z59309, AB019440.1, U63131, AC004983, AC005094,

AC006202.2, Y18450.1, AL022314, Y17037, M63495, U43077, AF095935, AC004398, AI155964, AI510573, AU045922, W33799, W42362, AA960516, AI664149.1, AA688562, AA467205, AA595492, AA573791, AA629772, AI332743, AI160935, AI510778, AI591019.1, AI457159.1, AA969944, AI539436, AI623125.1, AI188940, AA713971, AA610104, AA706786, AA582464, AI567836.1, AI207763, AI358329, AA157250, AI582710.1, AA744976, AI638507.1, AI039843, AI571784.1, AA640190, AA194089, W58500, AI565383.1 , AI381941.1, AA053629, AA480214, W58535, AA503086, AI640364.1, D51 182, AA253436, AA250750, AAl 12892, AI025123, T63135, AA969971 , AI610993.1 , AI207764, AA024425, AA935715, AA385688, AA043276, AA374540, AA083878, T62991, D31140, AI274547, AA775760, AA252726, AA522501, AA987599, AA172101, AI358015, AA092870, AA412321, Tl 1978, H86668, AI247739, R06066, T86931, H86515, H39234, AA064937, AI502660, AI106368, AI444536, C23347, AU056970.1, H32742, C93950, T37393, AI238361 , R04882, T38016, C91449, AR009920, 109636, 123493, 109629, 140358, A22940.1, 112873, A40345.1, AR022373, AR022395, 119103, A22942.1, E13132

SEQ ID NO:22 D83260, X87199, L44140.1, D83388, X74611.1 , D83389, D83261, Z80360, Z99123, AF021936, AB003364, AB01 1110, AC004084, U61295, J00752, Z48794, AF098760, X15938, X15939, AL031155, U15803, AB024929.1 , U78289, M86719, X07273, X78898, AL023861, AE000979, X59602, AF119361, U51 167, Z71483, AL008627, J00751, AI510573, AA518721, AA770719, AI155964, AA919842, W71922, AA208368, AI527584, AA530827, AA589702, AA050630, AAl 17695, W75487, AA645964, AA165828, W70754, AA734295, AA958490, W34195, W42215, W17699, W41966, AA014247, AA042019, AA041712, AI019834, AA833404, W85670, W13027, W54346, AA000184, W89228, W97044, AA270388, AU023492, AA276667, AA498405, AA254932, W61466, AA048354, AI391391, AU043001, AA073884, AA268731, W89303, W36983, AA049172, W08238, W42151, AA041974, W42212, W74851, W10543, AA268680, AA043275, T75223, AA385688, AA043276, R56012, AA312864, AA053735, AA083878, AA157345, AA969971, AA595492, AI207763, AA573791, AA969944, AI332743, T27009, AI160935, AA374540, T62991 , AA584930, AA584911, AI207764, AA629772, AA706786, AA713971, AA744976, AI591019.1, AI188940, W58500, W58535, AA194089, AI539436, AA157250, AA524052, AA887388, AA380353, AA354269, AA658541, H22719, AA654864, AA355097, AA776602, AI660486.1, AI437247, AI444536, AI106368, AI062974, AI231806, AI388676, AI577001.1, AI576976.1, AI579074.1, AI388808, AI135072, AI579223.1 , AI579480.1, AI579646.1, AA859295, AI578880.1, AI579275.1 , AI602634.1 , AI579680.1 , AI455073, Al 114110, AA696762, AI455992, AI063030, AI515739, AA949809, AI064036, AI064095, AA735407, AI292518, AA201662, AA201417, AA940989, AI519254, AA438981, AI534698, AA940891, AI456973, AI457018, AI516535, AA438754, AI259864, AI134507, AI516225, AI456244, AI133981, AI512793, AI546711, D40443, AI456517, AA392775, AI455781, AI443222, AI135061, AA941 157, AA735719, AA950551, AA942246, AA264588, C25459, C25152, AA390561, AI257135, AI386867, AI456885, AA202866, AI512216, AI513060, AI518575, AI520297, AI541707, AI542062, AI543888, AA951861, AI546617, AA949071, AA941206, AA735659, AA942105, AA438590, AI542988, A61947.1, A48810.1, A48829.1, 118491, 128510, A20359.1 , 108146, E02372, 141422, E03013, E08097

SEQ ID NO:23

D83260, D83389, L44140.1, AF020515, Z98304.1, AC004960, AL008630, AC002080, U29874, Z86000, AC005669, AC005513, AC004812, AC005414.2, AC003669, Z83822, AB008539, U91318, U81831, AL031255, AL022726, AC004724, AC002121, AC002402, Z92540, AC004722, AF098501, Z74618, AB020863.1, AC000386, AF064384, AB005166.1, AC003012, AC005474, AC007031.2, AB003306, AC000400, AC002558, AU045922, W33799, AI155964, AI510573, AI480534, AI643147.1, AI506184, AI019969, AA840485, C77168, AA987173, AA510625, C77404, AI509236, AI480531, AI614092.1, AU040587, AA537364, AA792818, AA518281, AA718656, AI466011, AA170450, AV047994.2, C88019, AI606196.1, AI607367.1, AI642000.1, AA821665, AI605163.1, AI035496, AA930386, AA56341 1, C77540, AI020864, AI464370, AA161901, AI504453, AA175915, X83327, AA510798, AA183711, AI050535, AA617383, AA830135, D31140, R56577, R56013, AA043276, AA385688, AI457159.1, AA582464, AI381941.1, AI567836.1, AI623125.1, AI510778, AA250750, AI160935, AA640190, AI188940, AI638507.1, AA194089, AI207763, AI539436, AI565383.1, AA744976, AI358329, AI582710.1 , AI039843, AI591019.1, AA595492, AA969944, AA480214, AA713971, AI332743, AA706786, AA629772, AA157250, AA573791, AA253436, AI571784.1, D51182, AA610104, AI640364.1,

AA503086, W58535, W58500, AA053629, T63135, AA935715, AA024425, AA134908, AAl 12892, C15370, AA281263, AI381897.1, AA420753, AA420795, AI085414, R02067, AA514630, AA25 I347, AA555042, AI290561, AI609569.1, AI290637, AA780972, R94646, N75756, AA496622, AA865459, AI052038.1, W22175, AI633397.1 , R33150, R98500, H84166, AA927464, R40243, AI431867.1, AI468668.1, R43249, R98518, N31247, AI081773, R43320, AA457416, AI502660, AA835613, AI007384, AI106368, AI388746, AI615179.1, AI070388, AI169616, AA866335, AI412695, AA875253, D65481, All 12231, H76868, AA686507, AI406709, AI502340, AA850799, AI170499, AI579107.1, AA898409, AI398060, AI399625, AI410463, AA901297, AI329998, AA898608, AI602826.1, AI412666, AA849825, AI412543, AI080878, AA882998, AA898981, C56533, AU005190, AI231961, 186417, A63573.1, 186415, 186416, 101852, 147056, 119103, A38528.1, A23425.1, A63257.1, A64062.1, A68826.1

SEQ ID NO:24

U37359, AF022778, AF073362, U58987, U60318, AF134569.1, AB010695, AC004472, L44117, Z73978, AC005746, AL008638, Z69792, AB013852.1, Y09629, AC006266, AF014953, AI037147, All 15949, AI561969.1, AI550158.1, AAl 14813, AI132067, AV001773.1, C76688, AA203842, AA208254, AA711715, AA206653, AA243252, AA706080, AA772644, AI208691, R69461, AAl 12856, W23633, W86391 , AI360182, AI640178.1, AI076395, AA658420, AA327854, AA333526, AI204278, AI369362, AA440659, AI389561, AA264398, AA539320, AA264980, AA820331, AI513019, AA942402, AI513643, AI389955, AI543536, C70910, AI576108.1, AI070374, AI576338.1, AA231815, AA750795, AI511175, AI638933.1, A12984.1, 125119, A68700.1 , A67171.1, A52398.1 , A47886.1, 146761, 146762, 146764, A47884.1, A14577.1, A52411.1 SEQ ID NO: 25

AF022778, U37359, AF073362, U58987, U60318, AL021747.1, AC003672, AC002062, Z95889, AC006566, AB025613.1 , AC003683, AC004442, AP000075.1, Z25809, U44405, AL009029, X63648, AC002460, AE001413, AC006434.5, Y14850, L19354, 33212, AB005234, AC004526, AL049497.1, Y14851, Z82195, AC003101 , D16583, X89514, AL021710, D16247, Z83235, AL008983, AL031771, AF107888, Z86094, U24152, AB007035, AC002560, Z99570, AL031018, AF142341.1, AF030304, AB006707, AF071884, AF059614, AB023032, Z36752, Z99261.1, X91660, AB026658.1, U53878, Z73286, AC002131, AC005508, AF079100, AI323787, All 32460, AI020209, AA204495, C79846, AI035620, AA536853, AA571383, AA591270, AA217733, AA555938, AA675244, AA921674, AA563506, AA450435, AA920930, AA537092, AA109126, AA589003, AA529573, C77471, AA591634, AAl 16739, AA588978, AA474888, AAl 17106, AA529304, C79021, AA591480, AA162184, AA155089, C77839, AA709489, AA466880, AI642311.1 , AA4101 11, AA265133, AA589145, C77072, AA575522, AA522389, AA285751, AA624447, Z74635, AI314712, AA522068, AI652139.1 , AI288910, AA206223, AA974008, AA599357.1 , AA932162, AA807167, AA599453.1 , AI637591.1, AA034479, AI572202.1, AI650940.1 , AI276014, AA614182, W03632, R92123, AI206893, AA988287, AI263519, AI242564, AA506923, AI468356.1, W24658, T18886, AI298371, AI277646, AI192319, AA995617, F36736.1, AA984490, F26599.1, AA827292, AI081822, AA872582, AI160205, AI478625.1, AI601129.1, AA983916, AI097123, T34012, AA279924, AI160742, AI300440, AA482258, F20966.1, H78681, AA468562, AI003164, AA984955, AA526574, R59956, R30773, AA082029, W87821, AI671687.1, R88644, AA361315, AA136572, AA354831, F36398.1, AI200035, AA974192, AA642957, AA745017, AA378797, AI023066, AI200585, AA715425, AI609596.1, D20944, AA852795.1 , R16278, AA576140, D79290, N22521, AI352221, AI216109, AI197929, AA887382, AA027293, AA635177, AA504590, AA480240, N92237, R07135, AI362945, AA932636, AI193810, AI0881 10, AA873539, AA682471, AA057620, AI186151, AA433405, AA946133, AA945897, AI328451, AA597601, D39329, D24519, AI407294, AI164605, AU061968.1, R30034, AI544517, C93933, AI328337, AI513801, AI164274, AU002123, AU033967.1, AU052365.1, AU060842.1, AI01 1217, AU037894.1, C88403, AI477124, AI497314, R65553, AA957838, AU037725.1, AI398683, AA940687, AA218507, AA940686, AI239179, AI398762, C23834, AI330907, AI385079, AI511966, AI600787.1 , AI677358.1 , AA949936,

T02776, C68683, AA940791, AI059084, AI577660.1, AU039812.1, AI397898, AU061886.1, AU061571.1 , AU034262.1, D69160, C41317, H37462, C70179, H35888, C70908, T76738, W06653, AI397213, AA657313, AI616684.1, AA949937, AI584979.I , AI063744, H37390, AR003149, A32895.1, E03799, E03335, AR019675, 166313, 170400, A56817.1, 170401, A29216.1, 175422, 114183, 175423, 114195, 178761 , 136465, 175427, 175419, 114194, 175420, 175421, 175418, A64703.1, A08586.1 , E08933, E00023, AR020964, 103286, AR000030, A64697.1 , A64699.1 , 103284, A01114.1 , A29490.1 , 108707, 195887, A13481.1, E02253, A64701.1, A64705.1 , A37615.1, 140371, 100547, AR022373, AR022395, A10398.1, A00785.1 , A29462.1, A00783.1, A00784.1, E01948, E06147, A29450.1, A02353.1

SEQ ID NO: 26 AC002553, AC006251, M97203, X73411, AF101041.1 , M29293, J05497, X73410, AL008635, AF003740, AL031254, Y00067, AB026660.1, Z82097, Z79599, AB011175, AE000560.1, AA816006, AI604002.1, W98579, AA691918, AI526343, AA023167, AA143467, AA733106, AA314502, R17289, H83769, AA345370, T89569, AA358953, AA085316, AA094893, W19892, W67454, AA247110, T82156, R10398, T86771, W73280, AI565243.1, AA080941, AI262599, AI263992, AI459026.1, AI492668, AI4721 15.1, AA933958, AI346037, AI241 111, AA782623, AA019887, AI346519, AA282333, AI244882, AI278691, AI476679.1, AI214189, AI347107, AA333501, AA836617, AA814709, AI214203, AI492667, AA400732, AI475840, AI298541, AI494464, AA741043, AI264537, AA969965, AI285048, AI199041 , AA354148, AA767553, C15272, AI475846, AI304338, AI247325.1, AI148129, AI041910, AA810941 , AI348239, AI291169, AA321958, AA678406, AA837209, AI146344, AA504327, AA676467, AA778410, AA846401, AI000419, AI024340, AA243430, AA352048, T64486, AA702872, AA847107, AI087243, AI126049, N40801, AA147393, AA679468, AA972167, AI434089.1, AI538766, W96128, AA424294, AA451743, AI123660, AI148484, AI291369,

T87406, AA810716, AI339925, AI480039.1, AA999044, AI235929, AA799285, H33618, C94017, AI353449, AA696367, AI353548, C28625, C28643, C93526, AI406656, C28285, C50677, A62358.1, A66650.1, E12861, AR013984, A57089.1, 181 174, A60173.1 , 133396, E13833, AR020969, A66552.1, A58853.1, 181173, A66553.1, 113892, A66559.1 , 181171, A22128.1, A58859.1 , A69288.1, 131095, A58857.1, 158526

SEQ ID NO:27

AC002553, U54734, AC004274, Z68131, U55375, Z82269, AF052106, AL031577.1, AC004098, U36756, Z73496, AB025631.1, M23221, AE000720, AL021749, D90912, AC002292, D86972, AA286643, AA522304, AA276944, AA065695, AI614802.1, AA648520, W67727, AA845447, AA700588, AAl 73197, AI609605.1, H97578, AI553914.1, AI361073, AA582850, AA426042, AA830128, AI367388, AA143466, AA757234, AA587480, AI017352, N66936, AA126939, AI245298, W67455, AI471199.1, AI457988, AA402248, AI189983, AA954621, AI245792, AI200305, AA412060, D59326, AA725312, AI635986.1 , N93123, AA962148, AI200033, AI399677.1, AA984035, AI302396, AI472786.1, AI362644, AA732015, W72025, H97759, C20580, R07575, W38649, AI085824, H83910, AI268814, R41966, F28077.1, W77754, AA826770, N91239, AI540736.1, AA279082, AA530936, AI382402, AA481472, AA169367, W67726, AA677793, AA330071, AA860559, AA700804, AA609563, T81813, R57954, R69408, H15627, H27566, T08883, AA297639, AA775768, T80751, AI420322.1, N31794, R68955, W05645, W67440, AA004779, AA583615, AA919107, AI589258.1 , AI609518.1, R39975, AA1001 17, AA156830, AA158743, AA621667, AI074233, C17813, AA995310, AA781230, AI304724, AI357834, AI608891.1, AI625220.1, AA523124, AI576440.1, Al 130322.1 , AI227616, AI104145, AI007878, AI044248, AI176979, E03288, 108092, 104632, A18397.1, E01467, A21571.1, A09202.1, A35395.1, Al 1978.1 , A04029.1, 127552, A27355.1, 140899, 114076, 140904, 100848, E00038, 174777, E00178, A45315.1, A41946.1, E07874, 143726, A32988.1

SEQ ID NO:28 U48734, U19893, D26597, AF1 15386, X15804, Z36797, X55187, AF093775, U41416, X13875, J03486, J02666, X62075, 74143, U41415, X13874, X59247, X51753, AL009192.1, Z36782, S66283, AC004560, AC005764, M65149, M86804, M85144, X61800, D82986, X68797, AJ011924.1, AJ011925.1 , M19364, M92288, U28387, Yl 1521, U00913, AF029667, M55075, M20391, AF049659, AC006271, AE000876, Z84819, AF049658, AI132340, AA039109, AA030873, AA050600, AA869608, All 16806, AI317336, AA265060, AI019642, W57010, AA033333, AA756213, AA497523, AA794222, AA607852, AA542357, AA867351, AA389009, AI099223, AA760101, AA733888, AA636878, AA033327, AA048059,

AA591043, AA467049, All 19186, C79156, W91243, AA718206, W98655, AA823795, AI035958, AA245084, AA939627, AA163055, AA792854, AA795384, AA469849, AA399735, AA403949, W98201, AA71 1821, AA207952, AA002732, AA718655, AA276564, AA5971 11, AA590753, W99855, AA221916, AA726158, AA013805, AA840112, AA760104, AA571361, AA794950, AA606423, AA755071, AA591998, AA608344, AA286001, AA144320, AAl 19163, AA267688, AA591115, W14056, W09813, AA790706, AA672798, AA915160, AA239694, AA407975, AA068062, AI596211.1, AI592346.1, AA986495, Al 117698, AI035704, AA023969, AI006572, All 15060, AI036569, All 15264, AI035780, AI663151.1, AI037172, AI173796, All 191 15, All 18977, AI035788, AI006532, AI036719, AI156861, All 14974, AI131659, All 19198, AII 51787, AI037056, AI151785, AL047603.1, AA129723, AI338492, AA709156, AA583155, AA580212, W65372, AA741013, AI453778.1, AI564985.1, AI568972.1, AA312012, AA658060, AI273379, AA130451, C18172, AI309142, C06273, AI420716.1, AI147600, AA984144, AA658055, AI653971.1, AI283351, AI433966.1,

AI205107, AA159354, AA635973, AA476888, AA149934, C06155, D83843, AA804798, W61307, AA079279, N94729, AA888055, AA864433, F 18836.2, AA857188, AA968700, AA860502, AI494454, AA769091, AA368907, AA664019, AA604905, AA057696, 85377, AA148549, AA938518, T08563, AA080946, H00427, R20827, R66641 , AA834121 , AI141654, AA134086, H28790, H25414, H00428, H00955, R94564, AA552159, AA969217, AA514914, AA830417, R20782, AA514919, AI128943, AA079449, R52047, R20891, R52046, F16280.2, T49685, H46560, R42007, AA147199, D82247, T08562, AA852880.1 , AI590894.1, AA988093, M62209, R27898, H28764, AA160770, AA928567, AA737577, AA723515, R72373, R94565, T69050, AA551753, C18948, AA328220, AA683006, AA309633, AI548249, AA063656, AI496971 , AI544547, AA848941, AA800206, AA080817, AA925873, AI178827, AA944553, AI230168, H33963, AI011763, AI231061, AI235159, AI012057, AA567651, AI010583, AI073202, AI176994, AA697902, F23022, AI518443, AI044058, AI555472.1 , AA926277, Al 177468, AI578284.1 , Al 176108, AI230571 , AA696880, AI229787, AA900462, AI232283, AA946292, AA924731 , AA720416, AA956707, AI176576, AI179210, AA955493, D34804, C60739, AA264106, AA263778, AA439762, C63031, C63929, C64397, AA800218, All 37505, AA390645, AA567595, AI385099, AI453974, AA849747, AA940720, AI384290, AA439198, AI106351 , AI331439, AA698095, AI456910, AI175096, AI330989, AI331314, AI332152, AI354002, AI294443, AI331926, AI330468, AI330546, AI411001, AI010821, AA698489, AA698488, D35859, AA950468, AI618130.1, AR018763, AR018849, AR018781 , E05171, A70393.1,

A67852.1, A67854.1 , A70394.1, A70392.1, A63599.1, A07822.1, A70398.1, A63600.1, A70382.1, 114942, A63605.1 , A70384.1 , A40404.1, 133090, A40408.1, A63607.1, A70388.1 , A70408.1, A40410.1

SEQ ID NO:29 D80007, AF055668, AF055669, U21688, D00702, AF021240, AF123593, X70842, X59397, S53103, AF021242,

AC005662, AL023096, AA510676, AA645511, AA870137, AI154187, AI 155985, AI613826.1, AA028338, W44001, AA511476, AA230933, AI481396, AA413046, C89275, AA537279, AA617451 , AA517438, W41139, AI415395, AA675301, AA863640, W14583, AI603915.1, AA143972, AI326261 , AA675300, AI272487, AI585489.1, W10702, AA929866, AA796560, AA124404, AA413714, AA615566, W34183, AV032204.1, C88996, W64978, AI430527, AV030110.1, AU042246, AA544765, AA267175, AA560701, AA592382, AA981828, AV006873.1, AA638757,

AV028681.1, AA407227, AA254801, AA839868, AI182089, AA238693, AI426414, AU016037, AA108899, AA274574, AU042862, AU016038, AI182079, AI662025.1, C87674, AA536770, AV026581.1, AA185650, AA541940, AA546749, W33384, AA792080, AA154814 , AI160467, AA595718, C18820, AI208315, AA666405, AI129469, AA548980.1, AA564369, AI493057, AA480184, AI671557.1, AA424797, AI288158, AA426622, AI147684, AI337075, AA307347, AA278932, AA325802, N46726, AA349945, F32975.1, AA426630, R17205, AA317447, R25920, AA573438, T79364, Z45016, AA311984, H63039, AA210832, AI206221, T79795, AI635341.1 , AI657051.1, AA100054, AA699967, AA074398, AI051229, AA618039, AA774741. N93074, AA369820, AA494546, AA699823, AA985393, R49286, AA724128, AI624172.1, AI653105.1 , AA449934, R02487, AA572774, Z36996, W78826, AA487951, AA699986, AA825221, W58138, AA316671, R99667, AI535689, AI638330.1, R16310, N29041, AA002028, AA099816, AA404344, AI025453, AA766709, Rl 1267, T26409, AA419565, AA997726, AI136610, AI461291, AI437309, AI410864, AI497219, AI168991, AI490343.1, AA660741 , AI213288, AI547986, AI172597, AI489623.1, AI522826, AI454069, C26539, C26044, AA898979, AA762033, All 12472, AI354022, AI171304, 125171, 108489, A49206.1 , 108490, A49208.1, 103259, 132885, 109606, 141388, A22393.1 , II 1714, 123867, 109479, 123903, A21198.1 , 156080, 141390, 123934, 186263 SEQ ID NO: 30

AB003582, Z35663, AF11 1942.1, U00955, U00930, U15038, AF072268.1, L22545, X74734, X74733, AF054907, U34609, U27807, D17546, L15319, AF076674.1, L16898, Z79604, Z95559, Z79998, U67078, AC004512, J03998, U80440, X87941, D13228, M86518, L33260, AF078157, Z84205, X52482, AC006422, AL008987, Z73018, AL008715, AF063008, S68871, U18985, X98857, AC002107, AB018343, 86602, X12796, Z78545, AE000135, AC006486, AL031764.1, U32378, Z99107, Z66494, Z81092, AF010465, D13044, Z72672, U23147.1, AF025462, AB007877, X67671 , U05593, M74118, M55017, AL031183.4, M59706, D88384, Z93778, J02732, U10925, 25062, Z99753, L47221, U88622, U19944, AF013962, M21683, U69668, AF080542, AB009080, AF060174, L22568, X81357, M60802, L22567, AF015906, AC002106, J04943, U91339, AEOOl 174, X58692, M261 10, AA501220, AA413894, AA545071, AI006989, AA414717, AA413931, AA692262, AA124718, AA644787, AA184530, AA414255, AI608097.1, AA254241 , AA204345, AI645772.1, AA546413, AA474204, AA537405, AA960184, AI463190, AA154351, AA762263, AI467406, AA415569, AA790480, AA798284, All 18927, AA473696, AA607172, AA097281 , AI5861 14.1, AA008253, C80564, AA793428, AA797955, AA116682, AA123743, AA388279, AA560832, AA103656, AA275567, AU041316, AU014623, AA220725, AI503266, AI550256.1, AI325822, AA220281, AA096809, AA414760, AA798375, AA522310, AA795527, AI427600, AA250667, AA445091, AU015737, AI648759.1, AI098917, AA870830, AI1541 13, AA120232, AA517672, AA068782, AA107405, C81382, AA215227, AI152456, AA822242, AI158873, W64747, AU015657, AA066952, All 16700, AA123213, C80585, AA607305, AA561640, AA467444, W97542, AA895398, AA880584, AA544265, AA673225, AA109989, D21623, AAl 18599, AA216996, AI12981 1, AA573294, AA044623, AA431630, AI125299, AA873150, AI040056, AI088660, AI052744, AI143468, N35166, W79798, AA431345, N35246, AA969145, AI473349.1, AI343799, AI028340, AA707997, W74247, AA491326, AI247482, AA971587, AA837427, AI042280, R15927, AA075430,

AA805745, AA621276, AI083576, AA496266, AA043503, AI339495, AI339139, AA767646, AA810773, AI360490, AA836127, N44909, N88182, AA909653, AA132094, AA811534, AA505132, AA490505, AA917728, AA629216, AA634532, AI572897.1, AA953078, T29750, AA912987, AI190735, AA992725, N93741, AI539500.1, AA652541, W25866, AI361041, AA171429, AA913812, AI659798.1, H92306, AA252304, AI669516.1, R55055, T57289, H87389, T56603, R08344, AA027928, AA490867, AI480010.1, AI561 169.1, AA496909, AA580606, AI123941, AA576566,

AA620502, AA730118, AA372734, AA166900, N91710, AA853296.1, AI374664, F27280.1, F28818.1, Z19557, R39203, W81404, AA181351 , AA351039, F25824.1, F22203.1, F32534.1, AI179296, C52472, AA041009, T76660, H76140, AU060597.1 , AI235309, R90523, T22992, C22922, H34426, AI059084, C89964, AA951682, AU039202.1, AI485933.1, AI558972.1, AI517768, AU039281.1, Z46697, AI485735.1, C89893, C92481, R47177, All 11998, AU034788.1 , AI598324.1, W43801, AI460844, AU053913.1, AI331597, AI415981, H31975, D65257, AI058338, C52267, C53848, T44623, C94881 , AI145040, AA848373, AU062029.1, AI494986, C55899, C60003, AI621775.1, H34750, C35374, AI586631.1, AI443979, C38600, AU062159.1, AI486280.1, AA925172, C54298, AA943835, AI171577, AI170908, Z24524, H32221, AI099554, AI437879, T41463, AA858936, AI440561, Z30478, AI100451, AI494816, AU060757.1, C27777, C31220, C34754, C56603, AA891555, C90006, AI021789, AU029338, AU002236, AA394554, N96614, AI055261, AI164717, AI437064, C25656.1, AI011951, AI514017, AI176695, AU053195.1, AI488511.1, AI410617,

AI496384, AI641373.1, AU065381.1 , AU029500.1, 151044, 101383, E01609, E01608, A00764.1, 192772, 190008, 143820, E02462, A3881 1.1, 169387, E13315, 133396, A20359.1 , 170401, AR002611 , E04896, 170400, E08230, 156651, 186194, 117189, A59616.1, 117185, 113521, 113520, 152048, 182816, 185817, 185812, A36718.1, 133400 SEQ ID NO:31

AB003582, AF016425, U91328, U35641, AL021879.3, U68174, U32446, U31625, U36475, AL009047.1, AF043695, L15188, M96150, AC002493, U61953, U63926, Z70751, L15314, U27083, AF039719, L14429, X54061, Z73907, AI606472.1, AV026932.1, AA461916, AA254428, AA139085, D77591, AA840125, AI666765.1, AI606628.1, AA919797, AA739471, AI642108.1, AA200862, AI647641.1, AA170629, AA592191, All 17556, AI607952.1, AA125128, AA204572, AI645907.1, AI173969, AA2611 11, AA616368, AA177474, AI132359, AA636166, AI591537.1, AI426332, AI226253, AA287999, R62682, AI453362.1, AI264590, AA831544, AI354355, AA287935, AA666074, AA021049, R15926, AI261510, AA132007, AA644663, AI473492.1, T90054, R62629, AA075381, AA491322, AA450151, AA531040, AA992324, AI434681.1 , AI571046.1, AI248612, AI650613.1, AA283604, AA101106, AA398112, AA363221, F23255.1, AI408748, AA945774, AI233193, AI598788.1 , AI406920, AI058858, AA800914, AI012637, AI177634, AI502828, AI676929.1, AA874839, C07240, AA859628, AI175753, AI104374, AI233631, AA924122, AA925465, AI455329, AI549032, AI548826, AI657631.1, AI549031, AI437396, A18079.1, AR022169, 155948, 159684, 169352, A171 15.1, A67425.1, 156872, A51688.1, AR022373, AR022395, 112874, A01796.1, AR012052, E06949

SEQ ID NO:32 D49817, AF056320, D87245, D87243, D87247, D87244, S77845, D87241, D87240, D87246, D87242, AB006710,

AF041831, AF041827, AF041830, AF041828, AF041826, AB012229, AF041824, D49818, S54076, AF041825, M19938, M64797, AF041823, U15177, AF110958.1, U84724, Y00702, X15579, X15580, M15685, J04197, M64323, S55569, AF041829, M34241, S70453, D25222, D25223, AJ005577, S67900, L27084, AL020991, Z83821, AJ005578, X61956, X98848, X98847, X74563, X65958, U41558, L13738, AL022023.1, AF049895, AF124929.1, AF070717, AC004083, AJ131213, L81766, X53095, AC002194, Ml 1794, AU036054, AI037207, AI644411.1, AI326331, AI265388, AI021341, AI035957, AI663904.1, AI386013, AI529513, AA104899, AA107038, AA959269, AA259918, W15760, AA109028, AA397024, AI048602, AI529512, AA038178, AA212882, AI528961, AI596603.1, AA606776, AU021029, AI006670, All 17478, AA276983, AA690507, W66728, W0831 1, AA008094, AA008587, AA498148, AA672158, AA692875, AI156797, AA238526, AA692754, AI047517, W17450, AA238155, AA498485, AA592576, AI155978, AA839409, W47800, AA002271, AA212331 , AA760244, AA241761, AA882063, AI425261, AA086590, AA088999, AA450585, AA764288, AA387250, W82750, AA276319, AA245963, AA155308, All 17500, AA637835, AA002885, AA064210, AI604392.1, AA463459, AI262563, N23313, AA282463, AA281981, T03795, Z24787, AI572739.1, AI473585.1, AA732066, AA807070, AA324504, N32473, H47404, W27604, T62734, T62884, AA994528, AI401563, C23067, C23192, AI389739, AI513846, AI062079, AA997994, AI354213, AI547848, AA859449, N60127, AI232706, AI01 1564, U31295, C23488, C23498, AA041 104, AI327728, C23512, C73020, C23516, C23487, AI044877, H35624, C23515, AA819697, AA941531, C23517, AI071154, AI398096, AI065761 , AI637202.1 , C10324, AA945153, A01474.1 , A01475.1, 122481, 122486, 141428, E02337, 101637, 162306, 182495, 130970, 196177, A39603.1, 115826, A0981 1.1 SEQ ID NO: 33

D49817, AF056320, AF041830, D87244, D87247, D87243, D87245, D87242, D87241, D87240, D87246, AF085891, AC004028, AC004761, AC005027.2, AC004448, AL008731, AF017104, AC006958, AC004673, AL008635, AC004927, AC004711, AL035408.5, AC004024, AC005384, U82671, AC006040, AC004674, AC004001, AC002076, AC002078, AL049633.3, AF067846, AC005284, AC006566, AL022165, Z93931, AL035671.5, AC004617, Z92542.2, AL033524.1 1, AL031733.3, AC005195, AC004903, AC005365, AC004067, AC003082, AL049565.3, AC002551, AC003991, AC006101, AC002300, AFl 10324, AC006368.2, AC006121, AC004540, AL023284, AC006926, AC003953, AC006377.3, AC000087, AL009172, AC005279, AL034349.3, AF001549, AC000068, AC004990, AE000659, AC005007, AC0041 12, AC004508, AC005695, AC007001.2, AC003983, AC004856, AC005221, AL033504.3, Z22800, Z93942, AP000119.1, AC004010, X86012, AF047825, AC005510, AC000060, AC003666, Z93242, AC004007, AC005833, AC002461 , Z95328, AC004552, AC004384, AP000132.1, AC002287, AC005865, M95623, AC002394, AI644411.1, AI326331 , AU036054, AA771586, AA208227, AA763145, AU035549, AA763350, AA553083, AA237248, AA624850, AI607557.1 , AA798390, AA537660, AA173020, AI530357, AI120704, AA289308, W53048, AA709792, W14745, AI047878, AA250177, AI182329, AI674428.1, AA635720, W78940, AI078168, AI076629, AA069359, AA069247, AA020850, AA551369, AI350338, AI363842, AI299777, AA931284, AI038776, AI373775, AI373258, AI470966.1, AA482147, AI224486, AI497836.1, AA885520, AA204774, T03614, AA425126, AA424313, AA564120, T91869, AA722427, AI168785, AI539477.1, AA962537, AA847073, AI093937, AA728963, AI281 197, AA233305, AA460258, AI246337, AI343255, T41024, AA557606, AA128913, N55081, F06102, F11152, R91132, H49193, T87273, AA621428, AA004635, R15347, H13351, N28811, N46199, AA171692, AA262227, AA628310, AI205827, AA127255, AA521374, AA625602, AI123137, AI055852, AA255634, W88780, T62743, W00726, AA994528, T64240, T68129, W05737, AI401563, AA243683, T67567, T68815, T71759, AA181575, T73160, R98312, D20281, AI282122, T61423, T68145, T73547, T74632, T73693, H97381, AA481133, AA676631, AA700882, R98068, AA862511, T73271 , N24799, R15209, AA243708, AI384053, D39547, D39557, AI008547, C26609, AI512288, AI512289, A51 135.1, 122486, 122481, 191983, 122785, 166262, E02657, 191769, E03391, E00418, A64588.1, E03392, A00200.1 SEQ ID NO: 34

U01 139, AFl 19164.1, AL031597.7, AC004245, AC007178.4, AC002366, X06908, AL049488.1, M64277, Z47073, X67813, X66218, AL031229, Y10983, X67050, X84996, U67551, AE001379, AF131775, AA444450, AA413633, AA032944, AA01 1740, AA170933, AA445063, AI019160, AA855757, AA174904, AA106259, AA518999, AI272577, AA947691, AA765947, AI525873, AA780448. N88951 , AI292015, AA442405, H91985, AI431847.1, AA769068, AA494443, AA810758, AI318348, AA633743, AI084487, AI352528, H20802, AA578819, W24964, AA193125,

AI63 I593.1, AI1271 10, AI218706, AI631812.1, AI611 150.1, AI379177, AA630879, AA503096, AA418466, AA263132, AA853480.1, AA767083, AA866195, AI203275, AI214077, AA677435, AA596024, AA195476, D59397, AI270536, AA992457, AA173591, AI240783, AA765257, AA722220, AI352414, R85498, C60926, C44543, C92581, AA536569, AI549005, AI577194.1, C84039.1, AI179999, AI179624, C90803, AI547577, AU034720.1 , C93873, AI179460, AA957340, C90627, AI599186.1, C89893, AI575384.1, AI485055.1 , 152101, A12146.1, A12755.1, E03879, A41497.1, 162710, AR022306, 123762, 134456, E04373, 164526, AR008485, AR008474, AR008473, 134457, E02497, A45919.1, 134458, 134459, E02220, 107977, AR001606, AR008472, 123460, A24287.1, 183401, 183400

SEQ ID NO: 35 U01139, AL031684.11, X05914, D37887, U33449, AC002404, Z48755, AC006248, L35107, AB018114, U33450,

U67557, AL023095, AF106592, Ml 1327, AC005037.2, AE001438, L16560, AC002540, AL031073, AC005876, Z68333, X61239, Ml 7513, AL023281, AC000106, Z98043, U77854, AC002447, Z75746, AB026652.1 , Z81032, AU045794, AA855253, AA178644, AA213292, AA231343, AI664137.1, AA4131 14, AA168370, AU045797, AU042463, AA445063, AA174904, AA409225, AU015733, AV027798.1, W98292, AA414727, AA103769, AI006231, AI139364, AI218678, AI096332, AI458051, AA046520, AA022892, AA827111, AA993891, Al 188281, AI311005, AA453435, AI362529, AI459074.1, AA046612, C16029, AA765947, AI525873, AA995562, AA987431, AA853997, AI650849.1, F31785.1, N79896, AA226443, F35756.1, AA226590, All 86189, AA203258, AI561 123.1, W58557, AA047437, AA875842, AA931554, AA977805, AI095753, AI377507, R49007, AA424553, AA709042, AA931462, AA348260, AI023483, AI167302, AI347736, AI366727, AI476255.1, R78745, AA343527, N30348, H12792, AI655467.1 , R82272, AA917907, AI090219, H03958, AA973755, AI093579, AA772695, AI128281, N48863, AA581573, AA098978, AA149648,

AI609942.1 , AAl 94969, AA009861, AA236889, AI022130, AA782106, T25462, AI084529, AA888853, N92587, R76998, AI221007, AI362557, AI285412, AI274861, AI264779, AI309998, AI636254.1 , AA962495, AI334147, AA706222, AA482724, N75832, AI421045.1, AI349116, AI376079, AI372898, AA587812, AI147618, AI096659, AI176212, AA801413, AA891042, AI029315, AA998967, AI232767, AI484819.1, AAl 16210, N98132, M75842, U38033, AI059570, AI059076, AU060339.1, T44877, E01546, A51764.1, A15353.1, A15354.1, 132307, E00038, A58934.1, 114046, A06133.1, A06129.1, 114048, 117504, 114051, 114050, A08891.1, A23184.1, 114047, AR009805, 112361, A12418.1, A06131.1, 117503, A23158.1, A21622.1, 100848, 113767, E07175, A58933.1, A58932.1, A23159.1, 114049, 117500

SEQ ID NO: 36 AC006193.3, U63409, Z81 121, U39574, AC002044, AB026644.1, U23443, U49953, AF082077, AB016885, AC007175.1, AF053725, Z95395, U84890, Z72006, AA245703, W64239, AI510622, AA763740, AA589807, AV043247.2, AA250407, AI585450.1, AA522344, AAl 18067, AI325769, AA276124, AAl 10650, AA276084, AA106797, AA530618, AI368109, AI657030.1, AA077662, W30989, W26365, AA076765, AA078297, AI439623.1, T43611, AI563387.1, AI211256, AA966240, AA787771, AA787988, AA785273, AI210879, AI209729, AA391392, AA785333, AI211707, AI212122, AI212031, AA783382, AA783723, AA788070, AI514749, AA786098, AA787897, AA787097, AI327553, AI213060, AI211989, AI211043, AI209715, AA966743, AA785789, AA785589, AA784785, AI515323, AI327704, AI213794, AI212902, AA942425, AA788189, AA786118, AA785358, AA786912, AI209610, AA788069, AI327959, AA785782, AA783934, AA783397, AI212656, AI209470, AA783714, AA202831, AI212353, AI210214, AA966079, AA898672, AA788035, AA785332, AA390378, AI667826.1 , AA966181 , AA785697, AI327971 , AI327961 , AI213686, AI211682, AA949438, AA787772, AA786394, AA783629, AA783603, AA966756, D34814, C69484, AI438077, AI483915.1, AI043537, AI626724.1, AI495163, AI486398.1, AI487689.1, AI494701, AI442677, Al 1189.1, Al 1 190.1, 114360, AR002552, 142103, 114357, A48542.1, 114358, AR020969, AR009920, E01979, E02627, E00987, 121869, E03528, 127091, 119994, A12297.1, 144702, 144700, 144701 , 144520, A65720.1, A12522.1, AR016569, AR016568, AR019675, 104549, AR016503, E02629

SEQ ID NO: 37

Z92540, AC005508, Dl 1328, AC005609, AC005159, Z99753, AC005772, Z54306, Z14314, U64842, AC000026,

AF016420, AC004785, X98745, Y07848, AP000109.1, X96869, AC005389, AL034563, U14010, M76741, AF034779, AC004170, AC002059.3, M86723, AL033503, Z70682, AL031003, AC002367, Z54142.1, M86709, AF029683, AC005368, M21635, Z83240, U25440, D26137, S69790, AB020707, X89391, AC004805, AL031543, Z84470, AC006501, AC005688, AL035555.10, U70852, U07366, AC006157, AC004385, AF037261 , AI415391, AA989738, AA623446, AA590109, AI035339, AA103137, AI325124, AV044985.2, AI427784, AI197082, AI561916.1 , AV036459.1, AV037551.1, AA390051 , AV034318.1 , AV035393.1, AA986430, AI157519, AI116208, AU041091, AA014905, C80228, AI060827, AA345854, R77044, AA662655, AI625045.1, AI570383.1 , AI242456, AI469086.1 , AA905873, AI274581, AA400052, AI143501 , AA974367, AI381657.1 , AA678138, AA676551, AI400147.1, R49939, R49938, AI648386.1, AI393926.1, R76882, AI631973.1, AI304908, AI081062, AI299091, N66118, N55016, AA664404, AA831586, AI635187.1, AA010487, AA339940, AA504924, AI185951 , AI332301, AA364258, W81092, AI351464, T34677, H82089, AA632333, AI092180, N83590, T98503, AI044549, AI012163, AI484234.1, AI482974.1, AI484230.1, AU003377, AI482971.1, AI482990.1, AI575701.1, AI555543.1, AI179431, AI101527, T09816, AA186314, T26171, AI169299, AI228530, AI602993.1, C91208, AI045636, AI532848, AI584880.1, AI066222, AA851746, AA866503, AA550607, AA739567, AI066285, AA140614, AI236395, AI171094, AAOl 1988.1 , AI407713, AI559074.1 , All 10508, W00177, AI257843, AI658114.1, AR012053, 125986, A56787.1, 115087, 184552, E03690, E03687, 187840 SEQ ID NO:38

AC005747, M74161, AB026644.1, Y08257, Z29522, AL049813.1, Z33620, AF049617, U26707, AF002817, AF023661, AB006458, AA245703, W64239, AI006615, AI036502, AA597087, AI429010, AI605500.1, AU051532, AI121505, AA197709, AA543707, AA673804, AI323520, W36675, AA475816, AI666529.1, AI505997, W88229, AI368109, AI657030.1, W30989, AA077662, W26365, AA076765, AA078297, T63274, AI515323, AI514749, C96225.1, AA390378, AA140598, AA942425, AA202831, AI213553, C72876, AA695184, AI487689.1, AI532028, AI486398.1, AI212540,

AI210410, C69484, AI483915.1, AI031452, 141422, 162858, 109215, A65264.1, 128467, 128466, 142103, 128468, 141330, 105094, 105091, 109216

SEQ ID NO:39 AB011478, AF037261, AP000120.1, AL022101, AA989738, AI415391, AA623446, AI035339, AA986430, AV015789.1, AA390051, AA178458, C76229, AA186181, AI553055.1, AA345854, AI274581, AA662655, AA905873, AA400052, AI469086.1, AI242456, AI570383.1, AI625045.1, AI143501 , AA974367, AI381657.1, AA678138, AA676551, R49939, AI400147.1, AI393926.1 , AI648386.1, R77044, R76882, R49938, AI216687, W22215, AA088921, AI044549, AU031505, AA817766, A18521.1, E01304, 185620

SEQ ID NO:40

AF070523, AC004787, AL034404, AL031716.8, L35663, AF032455, AC004675, L35664, AC005612, AC0021 16, Z25749, AF038458, AL049171.1 , AC006392, AC000100.2, AC004976, M59317, U28929, AF088219, X98833.1, U63834, L25131, AP000099.1, AA222765, W59671, AA097900, AI182252, Wl 1401, AA051031, AA797610, AA710408, AA967556, AA717935, AA560200, AA794040, AA871635, AA871678, AA154429, AI661797.1, AI425453, W29555, AU035139, AU035393, AA714791, AI570372.1, AA071 179, N92494, W02193, AA928916, W58390, W52978, AA192376, AA278398, AA083615, T86811, AA578003, AA608786, AI077911, AA092532, AI434484.1, H03590, H44243, N88629, H25977, AI057310, AA769743, R82460, AI478505.1, AA569765, AI270619, AA248471, W24795, N44506, AA093674, R83437, R83429, AA009662, AA036868, All 46476, W16602, AAl 43582, H78436, AI052425, AI630062.1, N74004, R39633, H00365, T93191, AA297213, AA080889, AA249377, AA309028, AA009661, T97284, AI523284, AA095247, AA084246, AA430087, C05938, C03461, N34780, D80224, D59738, D59803, C14373, R78724, C17464, AA263026, R59236, Z44435, R17802, AI129173, H05235, AI142543, AI461526, AI665972.1, AA699075, AI395704, AI061987, AI395269, AI395400, 196198, A16257.1 , 188862, A16258.1 SEQ ID NO:41

AF056359, AL023773.1, AB002389, AC007156.2, AA821342, AA198254, AI286749, AA870126, AI663673.1, AA596129, AA038523, AA870705, AI591664.1, T59268, AA299257, AA657729, AA852211.1, AI609700.1, W65400, D31528, D31541, AA319726, AA382381, AA382234, AA364833, AA622501, AI538117.1, AI652363.1, D25665, AA133232, T36186, AA436115, AA135673, AA884806, N91600, AI264327, AA128760, AA129755, AI093292,

AA232960, AA468604, AI417825.1, AA621574, R70347, R92801, N54406, AA262674, AA352981, T70171, AA622098, AI318565, AA861212, H16602, AI354454, H00752, AA628732, AI267232, AI267384, AI078745, AI474673.1, W69399, AA314050, AA489344, AI185884, C82724.1, C83580.1, AA438381, AU060005.1, AI210138, AU058483.1, AA390900, AI211858, F14598, AI386714, AA783848, AU060017.1, AI210129, AR020615, 176208, 106168, 101006, 117185, 117730, E07665, 189854, 189856, 117735, 117189, E07666, 114051 , A14707.1 , A51201.1, 116614, 158527, 158538, 175051, 123847, 114047, A14931.1, 114048, 114049, 118351, 114050

SEQ ID O:42

AC005844.7, AL031622, AC002123, Z82193, AL031133, AC005969, AC002365, AL031643.1, AL031584, AC006487, AP000072.1, AC003088, AL021997, Z82194, AC006464.3, AC005201, AC006142, AL021408, AC003684, AC004939, AC005189, AC006972.2, AC006384, AC0O4764, AC004802, U82694, AF074021.1, AC005392, AF036876, U49973, AC000025, AC005527.3, AC003010, AC005537.2, AC005228, AC006481.3, Z74032, AF016451, AC005186, Z99297.1, Z97992, AE001390, AJ224476.1, AC006471, AEOOl 1 15, AF008218, U67544, AL034402.9, AC003701, Z92547, AL032623, AL022726, D16236, AC004910, AC005213, AC004594, AC000003, AC002485, AE000786, Z98547.1, Z82604, AC005188, U90093, X15388, X87622, X51344, AC005554, AE001389, AC005864, AL023694, Z78060,

AC006539, AC005587, AF049132, AA274173, AA517527, AI082183, AA662437, AA024662, AA994712, AA382233, AA382380, AI494136, AI478176.1, N72023, AA834895, AA961977, AA828992, AA559210, AA459825, AA609919, N62213, T91094, H60040, T91239, AA769203, H67137, AA887286, AA808252, AA884090, AA830916, AA287337, AA877615, AA281449, AI587210.1, AA593295, AI609700.1, AA421744, AA452801, AA634323, AA971661, AI090486, AI289082, AA024968, AI272646, AA426303, AI148235, AI221431, AA258397, AI271647, AI435922.1, AA709039, AA419609, AA978105, AI092202, AA781428, AI039122, AI382511.1, AI052573, AA600736, AI391581, AA834031, W70308, N54488, AI364175, AA805775, AI350380, AA478719, AA708179, N91942, AA410897, AA455497, AA456579, AI270416, AI218226, AI084698, AI204305, AA774270, AA489209, AA446024, N67061, AI673545.1, AI628019.1, AI432010.1, AA999606, C83459.1, AA550297, C82603.1, AA495017, AI622048.1, AI622047.1, AI556272.1, AI533930, AI544972, AI667753.1, AR020615, A39382.1, A28439.1, 157013, A01560.1, A36402.1, 106721, A12527.1, 190201, A52254.1, A52140.1, 170103, 108800, 120815, 190191, A01561.1, A14133.1 , 101908, AR022664, E05720, A40105.1, A00221.1, AR022642, A48436.1, A16254.1, A70894.1, E05716, E05723, A08893.1 , A40106.1, A00219.1, 109307, A27642.1, 124773, AR022657, E03525, A0891 1.1, E02313, E05721, E08855, 186831, A40099.1, A70873.1, 112551, A40102.1 , A31099.1, E05722, E05206, A40100.1, A16255.1, A40096.1, A56786.1, 161427

SEQ ID NO:43

AF064861, Z98247, X52708, D63663, L46865, M76678, AJ001341 , AF027735, L26049, Z98271, Z77662, Y08911, AL030994.1, U89914, AF092051, AF058825, AC007192.1, AF082299, S74439, L22208, Z97341, U64904, AF027737, AC004293, AA185658, AI645233.1, AA041959, AA733559, AA879514, AA462293, AA183470, AA521582, AA791930, AU019949, AA560934, AA238848, AI155747, C76303, AA560338, AA794642, AI173441, AA000607, AA794660, AU046264, AA269393, AA051685, AI316068, AU045218, AI173590, C88259, AA986532, AU014886, AA726301, AA291276, Z43080, T30919, AA484992, T16876, AA247778, AI377710.1, AA210994, AI276200, AA610142, AA079333, AA852394.1, AA079283, AI683364.1, AA826038, AA629629, AI356399, AA642452, AA234289, AI337264, AI417421.1, AF072813, AA769905, AI660570.1, AI392942.1, AI102997, AI071631, AI385307, AI502515, C27657, H56817, AA753205, AU062947.1, D40685, T88181, AI259374, AU064324.1, AI239376, AA246373, D49248, D48506, D39349, D48938, D49206, D40580, C20345, D23884, T42841, H76194, Z25517, AI109065, C74478, AU030128, C72918, AI667210.1, C70622, C74396, C28108, C68647, AI670304.1, C74891, C99603, C25894, AU059908.1, AU057738.1, C73243, C74094, 195876, 195881 , 195878, 195879, E02722, 121323, E05293, E02081, 190008, A43647.1, A43649.1, A58329.1, A43645.1, A41272.1, AR001253, A27636.1, E12560, A06406.1, E02194, AR001494, AR001500, 116741, AR001502, 195887, E02465, E02199, AR001505, 124739, A06404.1, A10241.1, A68584.1, 195882, A46715.1

SEQ ID NO:44

U43293, AC002383, AC002128, AB007935, D12514, AC006462.2, AL022313, M24078, U37528, AA870210, AA596277,

AI153677, AA197769, W10331, AI131925, AA655736, AA986419, AA122665, AA561670, All 18316, AI663564.1, AA543641, AV047177.2, AA423215, AI195113, AA518547, AI647567.1, AI196401, AA475667, W08414, AA821530, AA404028, AI644946.1, AA162825, AA434914, AA959031, AA948591, AI220168, AA918556, AA904905, AI004650, AA909293, AA651874, AI040052, AI052643, AI521897.1, AA315914, AA846024, AI276133, AI452563.1, AA732326, AI521221.1, AI143397, R25586, N63758, AA083158, AI580354.1, R66081, AI572855.1 , R67802, AAl 13057, AI332453, AI627623.1 , AA252152, AA535874, H92882, AI633935.1, AA465181, AI263137, AI636673.1, AI634875.1 , AI375906, AA682627, AA492206, AI582606.1, AI435606.1, AI146340, AA251967, R33612, AI236097, AI180153, AA417470, AA417471, 124453, 124438, E03790, 124437, 104770, 116670, 116683, 189423, E02137

SEQ ID NO:45

U47110, X97854, AC004098, D87924, Z49126, AF051353, U40656, U17352, Y17138, M26651, U46893, AF083072, J02974, X98131, Y17137, AI529368, AI5931 18.1, AA241904, AA036429, AI425479, AA536990, AA414342, AA030172, AI049408, AA637184, AA240607, AA014933, AI154799, AA016933, AA041697, AI091298, AI375098, AI660316.1, AI435931.1, AI524203, AI571317.1, AI659324.1 , AI418486.1 , AI094880, AI675241.1, AI560264.1, AI224948, AI672681.1, AI084171 , AI423636.1, AI276183, AI246175, AI264589, AA835659, AI341540, AA410348, AA215710, AA258475, AA317548, AA764863, AI264852, AI143673, AI304322, AA543059, AA813462, H98014, AA551682, AA406408, AI312786, AA262869, AA215709, AA523975, AA479232, H98842, AI004617, AI498511, N56734, AI361640, AI515115, AA263455, AI516010, AA735642, AI519144, AA567492, All 14087, AI296577, AI236341, AI388216, AI576548.1, AI598367.1, AA042605, C93558, AI059885, AI071918, A70054.1, A70052.1, A38684.1 , 116615, 184465, 117755, 172654, 117524, 117756, 117758, E12746, A69563.1, A45258.1, 117525, 172653, 134034, 112220

SEQ ID NO:46

AF086317, AJ235273, Yl 1778, AF042090, AL031387.4, U43322, AC006123, U43325, M21276, AC005169, M38595, U58750, AL021451, Z98751 , AC005844.7, AL034377.1, S82691, AC004226, Z82058, AF100663, AC006213, Z99280, L19443, Z68116, AL031846, Y13408, AC004023, U29097, AC004926, AC002045, AF098504, AC004692, AC005398, Z80214, M18288, AI006304, AA096886, AA197701, AA013950, AA276858, AA608195, AA761971, AI674814.1, AA204693, AA465292, AA262434, W73354, AA767616, W73333, AA252525, AA648818, AI075941, AA187979, W65369, AI241748, H08500, AA872830, N33227, AA322188, AI215037, AI673146.1, T29502, H90761 , AA013315, AI289818, R23687, AA564134, AI631235.1, AA351 162, AA375063, AA083483, AA164999, AA507980, AI608803.1, AI085057, AI190190, H17159, D25257, AI278718, Z43956, N54983, AA075700, AI670855.1, AA313445, AI628506.1, AA969719, AA228015, AA058718, AA258291, AI365170, AI269300, AA962727, AA131517, AA057273, AI672085.1, AU061565.1, T42574, AI629069.1 , N97751, AA786148, AI069512, 107691, E03171, A51422.1, E03667, 107373, E04428, A16121.1, A62786.1, 138435, E03670, A28743.1, 108188, A70354.1

SEQ ID NO:47 AF086317, AF067606, AF125457, AL031387.4, X98739, AC005169, S82691, U43322, U43325, Z98751, X98738, AL021451, AC004883, U29097, AC004692, AF064858, AF091592.1 , AF064859, Z81592, AC004070, Z82058, AA276538, AA013950, AA197701, AI428348, AA276858, AA162670, AA013949, AA096886, AI006304, AI551996.1, AA608195, AA204693, AA262434, W73354, W73333, AA252525, AI075941, AA761971, AA648818, W65369, AA453653, AI674814.1, AA465292, AI374660, AA908731, AA831594, AA281080, AI147200, AA766128, AA187979, AA749119, AA767616, AA258291, Z43956, AA889787, AI193232, AA058718, AA322188, AA824347, H90761 ,

AA164999, AA868962, H17159, AI640190.1, AA313445, AA375063, AA057273, AI221093, R16835, AI365170, R23687, AI190895, H72054, AA851479, T42574, AI629069.1, AA786148, 122260, 122445, A28743.1, II 1616, E05381, E03629, 123429, 123419, 123414, 115119, A22127.1, A48775.1, 122443, E04428, 123420, 122432, 123417, 108786, 149034, E02167, A37270.1, 108787, 191962, A58904.1, A48782.1, A48779.1, A48776.1, 123421, 123418, 123416, II 1617, A00076.1, A00077.1, 123431, 123415, 111619, 111618, 108011

SEQ ID NO:48

AL049280.1, L15344, U46844, AC004015, AF073775.1, AC004991, U41 103, X98718, AC005701, Y07866, AC005751 ,

AF043084, Z81542, AA914306, AA386630, AA529628, AA386499, AV011861.1, AV034904.1, AA472991, AI607039.1, AI573543.1, AA279010, AI654057.1, N24002, W51873, AA215628, AI129169, AA642399, AI478789.1, AA252353, AA806034, AI494462, AA721744, AA805516, AI470516.1, AA515852, W48659, R43924, AA534309, AA190645, AA761615, AA585431, AI656638.I , W52095, W52847, AI478711.1, AA155623, AA316968, Fl 1933, H52265, AI003490, AA181 169, AA938438, AI041968, D56120, AA376800, AA343532, AAl 12761, AA345840, AA301631, AI051622, AA448849, AI220485, W94856, AAl 13786, H80982, W25540, AA292949, AA083489, R21214, AA308636, W67221, T97663, AA347236, AI358757, AA789079, AA315188, AA180483, AA088544, AA687534, AI655468.1, F31587.1, AA664304, D58990, W39480, AA190873, F00242, AA343799, AA425253, N47475, C06300, AA554136, AA687217, AA098791, T661 10, T61714, AA490997, AA488005, AA376086, T92525, N57402, AI652094.1, AA806389, AA452515, AI545400, AI512953, AI294286, AI296583, AA696925, AI294441, AI297495, AI513015, T01466, AA820982, AA750686, AJ234148, AI406511, C82888.1, C83744.1, 134297, E12511, 121438, 121437, 121436, A58240.1, E06596, 128845, A27529.1, 138760, A62217.1, A39962.1, E08680, 144066, A39598.1, A44511.1, A58393.1, E03156, E02262, E01185, 186264, A58395.1, 111609, AR022361, E06597

SEQ ID NO:49

L29059, D26018, AF060713, AL049481.1, AL049487.1 , AC007110.3, AB008269, AC005324, AC005957, AL035678.1 , AF067624, AL049751.1, AE001277, AU019923, AA790764, AA289012, AA274649, AA432829, AI153815, AI675365.1, AI367369, AA812199, AA130591, AI276671, AA088262, AA576986, AI554885.1, W67375, AA833632, C05699, H15177, AA496347, AA731379, AA371430, N92996, AA761272, AA730235, AA995351, AI570582.1, W73779, AA747918, AA805606, AA748462, AA262803, AA832453, AA278685, AA481121 , AI380252.1, AA595943, W03789, AA918362, H54023, AA244344, All 75594, AI045299, AI545940, T45626, AI497428, AI497059, AA550002, AI443954, AI109977, AA549994, 122796, A46440.1, 175061, 122798, 122787, A65999.1, 131747, 189451

SEQ ID NO:50

X71988, AF092977, M36470, AF092986, AB025641.1 , AF045450, AB019440.1, AB019438.1, AF017739, AL008628,

AF121782, X87148, L27948_> U10399, AC007125.1, AFl 17069.1, Z94277, AFl 17095.1, U82320, AFl 17101.1, W10466, AA097281, AV045817.2, AA182214, AA182285, AA244534, AA692973, AA71 1787, AI616238.1, AA509995, AA510108, W09442, AA210327, AA028342, AV0441 18.2, AA107935, AI475809.1, AA953569, AA757586, AA357776, AA777916, H30593, H26221, C84167, T41462, AI103270, AA697485, AI055470, AI437508, AA956292, T45723, AA955521, E06829, AR007118, 119367, A61529.1

SEQ ID O:51

AB025254.1, AL021713, U67476, AC002365, AF025462, AC003084, X52576, AB003151, AL035671.5, Z82203, X17072, M63176, L13028, AA125100, AA940381, AA474962, AA823551, AA796018, AI592091.1, AI042863, All 82307, AI042852, L26676, W52937, AA581819, AA053405, AI131436, W60448, N20536, AI367494, H20536, T52694, H84947, R39606, F10986, Z40529, F04085, AA384013, N29241, W78744, AI084738, AA766263, H50660, N88923, AI131238, AA906294, AI241748, AA642396, AA630797, AI094387, AA850501, AI228815, AI145641, AI502281 , AI555714.1, U83075, AI329948, D49194, AI545469, AA848626, 149914, AR000019, 138891, AR000018, 141428, E02040, A44436.1, A21365.1, 147707, A21373.1 SEQ ID NO:52

AC006501, U52364, D30733, X82777, LI 1172, AC005184, AL050089.1, AC004288, AC006265, AB025631.1, U15660, U20796, AF030104, X78135, D85391, D13160, AA914458, AI120766, AI597366.1, AA106588, AA982134, AI255504, AA222292, AI195443, AI132235, AI255753, AA717690, All 18602, AI255894, AA824102, AI265415, AI286961, AI529838, AA019963, AA015589, AL049006.1, H86143, AA558698, AA937328, AI471939.1, AA973792, AI473655.1, AA941 141 , AI401995, AI461604, AA649389, AA752733, AU002004, AA649390, AI438910, 102561 , 118303, A43598.1, A63129.1, 126124, 195674, 168291, 107427, E02076, 195673, 176961 , E05467, 132308, 168298

SEQ ID NO:53

AC006501, Z47795, U45241, D55677, AC006083, AF016436, AC004259, L26506, AC004600, Z98598.1, AF125443, U39364, AB009809, X91981, AF047663, L15387, X17548, AC005224, Z98551.1, Z49627, AC004613, AC002069, Z69724, AC007188.5, AA124618, AA184293, AI644134.1, AA200336, AA759554, AI131939, C79862, AI156921, AV029755.1, AA968147, C79876, AA526221, AI015849, AA058613, AA576477, AI453080.1, W74118, AI299960, R78207, AI150210, AA868829, AA424041, AAO 13272, AA036751 , N53365, AA740889, AA019923, AI376273, AI038661, T40212, N55912, AI554328.1, T41078, R27284, AI174640, AA057323, AA502684, AA249700, H86444, AA053317, AA504997, H23232, R63602, T10181, AI635849.1, AA563853, R17137, H52920, AA332512, H90598,

AA026241, AA151 159, AA600215, AI470215.1, AA098889, AA152020, AA723684, Dl 1524, AA102812, AA148370, AI151435, W01 199, AA128088, R32524, AA151499, AI091627, R32531, AA151495, AA933903, R81994, H03550, AA035074, AI128347, W86156, N92061, AI287259, AI071296, AA848853, AI012051, AI227883, AI058556, AI087481, AI087560, AI562409.1 , N97829, AI137600, AU063472.1, D73289, C91346, D71610, AA142289, Cl 1551, AA550104, AI402555, AU038875.1, D72656, C07626, AA698344, C28874, AA550157, AI293798, AI260863, C24185, AA735416, D72962, AA739987, AA390223, AA550096, 192820, E12157, 109512, 108921, 108774, 108777, 108920, 108775, 182521, A43598.1, E01662, 108922, AR007445, E02799, 140109, A59607.1, E05042, 144518, A14705.1, A03736.1, 156735, A59616.1, 156746, A22651.1, 125170, A59593.1 , A43592.1 , AR007448, 156733, 144733, AR007444, 131802, 146883, A29820.1, 175067, 160253

SEQ ID NO:54

X79560, AB006706, Z99774, AA571188, AA754667, AA874361, AI316772, AI098617, AI557700.1, AA160815, AA171879, AA159122, T31548, H23167, AA172145, H12990, AA074618, AA156185, AA868567, W02906, AA082540, AA236289, AA641033, AI160819, AI160959, AA864664, AI590976.1, W92296, W79177, N75140, C01022, AA897694, N52369, AI064198, AA439935, AR012159, 164540, 122489, AR006845, 138875, 128953, A62217.1, E12108, E00135

SEQ ID NO:55

U36476, AC004602, AP000124.1, S67830, X72794, U24441, D12712, Z27231, X72795, Z92544, Z82202, AC004080,

AF006043, M60806, AA472520, AI413588, AI481916, AI390125, AA667913, AI158454, W17685, W09056, AI594821.1, AI180813, AA606770, AI014673, AA171939, AI083920, AI096399, AA579859, AI678769.1 , AA837461, AI494245, AA614760, AA845317, AA176164, AI356496, AA984500, C20767, AA171551, AA953092, AI652026.1, AI653702.1, AI453299.1, R43419, AA768725, AI040243, H05631, AA161220, F32286.1, AA039678, W67653, AI161215, AI681 159.1, AA161443, AA806482, HI 1 127, AI361299, AI423300.1, AI640256.1, H28658, AI240851, N81151, AA630420, AI159875, H45266, AA777659, W68153, AI355285, AA576289, W63787, AA310115, AI460065, AA316052, AA459339, AA083801, AAl 82585, AA745703, AJ003351 , AI200598, AA024594, AI433956.1 , W05293, C73666, AI392054, AA739943,

AI029769, AI070854, AA955662, E04563, A64582.1, 176175, A12360.1, A07020.1, 191962, 117250, 179375, 113706, A06110.1, 123907, 125789, E08436, AR016396, A09896.1, A45356.1, E03738

SEQ ID NO:56 AJ006267, AF024534, AC004981, Z74245, AC005058, X83276, X99000, AC004836.2, AB013388, L07649, U56419,

X82018, U12539, AC005516, Z69730, Z68506, AC007066.4, Z49155, Z98755, Z68213, X64963, AI322465, AA013832, AA759527, AI627163.1, W12249, AA572634, AI156080, AI226446, AI315796, AI151867, AI272456, AI303153, AI097795, AI196133, All 16634, AA107359, AI195426, AI046470, AA189393, U92566, AI597339.1, AA940117, AI195524, AA967562, AI316864, AA647559, AAl 11221, AA792455, AV012471.1, AA326413, X85600, R08095, AI610247.1, AA292994, AA081972, AAl 02553, AA482133, AA011168, AA779485, AI088595, AA779638, H24844, T74509, R29637, AI 142981, AI148247, H98197, R66629, AA946609, AI368073, AI022982, AA742540, AA632088, W63701, H70920, AI284077, R67959, H99921, AI149779, H46510, W88776, AA427464, AA483171, AA934761, AA779468, AI079256, AA126413, AI087197, AA932316, AA927171, AA861894, AI680566.1, AA991725, AA862664, AA824433, AA978272, AA490994, R77334, T24004, AA877501, AA477905, N36542, H01025, AA983913, AA989298, AA099604, C67074, AI584932.1, AI491449, AI170645, C44068, AA894307, AA859229, AI558958.1, AI105426, AI103975, C50973, AI558353.1, C48424, C44717, AI626683.1, AA754347, C42717, C43398, C43675, AI658055.1 , AI066926, AA785496, AI544493, AI436934, C50485, AA849844, AI436930, AI227719, AI175549, AI175493, AI230411, C45013, AA749555, C45663, AI657605.I, AI585100.1, AI545752, C44620, AI639175.1, AI010492, AI171392, AI172298, E12852, 147056, E07872, AR008068, 120364, 133131, A21 101.1, 126613, A43540.1, A67171.1, E12200, AR009502, 134523

SEQ ID NO:57

AJ006267, Z98755, AEOOl 148, M30039, X69067, Z82060, Z69792, AL049321.1 , AC007258.3, AC003696, AF005773, AB010076, Z83319, L00585, AC005053, AC005083, Z83744, AC004167, AA607948, AA510992, AA239196, AA990386, AU014732, AU045014, AA178827, AA824001, AA572634, D18114, AI155491, AA692947, AI159493, AA563455, AU31257, AI419739.1, AI034216, AI374700, AA705643, AA515776, AA678577, AA974097, AI051034, R67114, X85601 , R94086, H44493, R66383, AA364541, H42683, AA226889, AA323033, AI652089.1, AA004454, AI032100, AI093774, AA004489, AI637941.1, AI632545.1, AA776411, N52019, W31365, AA235218, N64814, AI215614, W80495, AA883337, AA516315, AI002701 , AA553366, AA678007, AI049985, AI421684, AI583964.1 , AI057313, W78760,

AA682528, AI029291, C13445, C09496, AA539005, AI487416.1, AI487491.1, AR008068, 174786, 126613, A30919.1, A01967.1, A30921.1, E01702, 166313, E03799, A29216.1, A63380.1, AR019675, E02137, E03335, A09995.1 , A07647.1 , A30922.1, A30924.1, 191443 SEQ ID NO:58

AL049996.1, AC005071.2, S78798, U48696, Z97178, AF039698.1, AF032922.1, Y17148, U39066, AJ010903, U37573, AF027174, AF033097, U66300, AJ004935, AF045432, AF103726, Z49980, AJ001 103, AF030515, AF061786, U34048, G29058, AF147449.1, G29060, Y15421, X99051, U65376, AF033565, S83098, U52868, AF033096, AF079586, AC005996, X65215, AC005678, X99055, AL021997, AC004049, U44386, X80164, AE000604.1, M77492, AJ223292, S65693, S65694, S65683, S65686, X65335.1, M80484, S83538, AC004011, D86306, U80458, X64409, AL022154,

AL034488, M22135, AF027126, X70958, AP000124.1, AF022651 , S64849, AF045554, AB009287, X99568, M24488, X65320.1 , AF039399, AA981268, AA529639, AA547027, AA636308, AA068312, AA408246, AA209090, AA561951, AA266489, AA423389, AA541969, AI046693, AA822340, AI159435, AA260088, AA968256, AI195282, AA790417, AI173514, AF093453, AA123354, AA560141, AA529137, AI255841 , AVO 12293.1, AA184962, AV032794.1, AA612418, AI256251, AA867776, AA616127, W49839, W39691, AI6701 12.1, AA451825, AA046775, AA047503, AI565516.1, AA370734, AA248881 , AA160180, AA372829, H43466, N92184, R62724, AA215922, AA860942, AA689366, AI478927.1, AA249712, AA092086, H58760, AA093577, N84048, N88782, N88601, N83229, N84718, N84781, AA471338, AA095435, N83991, N84830, AA628416, AA095359, N84712, N83992, N83993, N88018, AA096046, N89520, N55698, AA247964, AA095641, N83168, AA096066, AA247827, N84855, N86694, N55721, AA093224, AA096061, AA249353, N87898, N88518, N87989, W23595, N84765, AA093861, AA089553, N84829, N89307, N84740, AA215908, N88496, AA093897, AA093219, N56555, N84828, AA093313, H71118, AA095511, AA090302, N56118, N86439, AA095475, N84016, AA089554, AA215911, AA096013, N84562, AA247828, N84723, N84575, N84921, AI566751.1, AA095921, AA095473, N56179, N55768, N85031, N84602, N84733, N86441, N84721, AA094237, AA247800, N84859, N84561 , N84788, N55638, AF041408, AJ241143.1 , AI483326.1, AI483209.1, AI354060, AI617228.1, AI353169, AI353694, AI483218.1, AI618568.1, AI618635.1, AA660164, AI353159, AI617214.1, AA933363, AI617432.1, D41672, AU061397.1, AI616967.1, AI616416.1, AA933116, AI616808.1, AI545236, H16477, All 10435, AU061924.1, AT000691, AI052974, AA933125, AU062120.1, AU001522, AU061975.1 , AUOO 1536, H14041, AA933253, H63055, AA273135, C93682, AU012213, AF092795.1, AU061862.1, AA660165, AA933350, H07848, N43727, AU061971.1, AI601746.1, AU061926.1 , AU061949.1, AU062001.1 , AU062063.1, A67425.1, A27635.1, 117659, A04374.1, 158669, E12149, 115713, AR007512, 185513, E08430, A14104.1, A14395.1, E07853, 159710, 148927,

A33348.1, AR018092, 115717, A22739.1, A22738.1, A22736.1 , Al 7063.1, A18050.1, A71440.1, A37288.1, A37287.1, A21625.1, A08586.1, 108013, 177293, A34041.1, AR018093, Al 1323.1, E12434, 124703, A50146.1, A42089.1, E02074, A22740.1, A21230.1, A20702.1, A20700.1, 105558, 183451, 183450, 143706, A46760.1 , E02073, 125179, 118794, A33349.1, A29288.1, A26449.1 , A26447.1 , A23903.1, A13387.1, A 13038.1 , 105487, 106961, 192483, 124920, A23997.1, 132615, E04616, 107816, 109132, 190245, E12615, 138604, 128832, A17373.1, 124701, A29286.1, A25930.1, A25929.1,

A21386.1 , A13388.1, A10871.1, A02710.1₎ A01519.1, 115148, AR013726, AR013725, 146906, 133632, A33354.1, 116086, A29284.1, A31636.1, A22741.1, A13371.1, AR009152, 190252, 144531 , 148933, 132196, A34035.1

SEQ ID NO:59 AL049996.1, U67571, AL031312, AC004743, AC005734, AL021633, U34879, AF029145, AF029143, AC003002, AF029141, AF029146, AF029139, M22645, AF029140, AC005261, AC004481, AF029163, AC006292, AB005242, AC004514, L48937, U39742, AF067216, AL035540, Z82250, AB020859.1, AF068212, L48722, U48297, Z33076, U36429, Z78015, AB007645, AF077533, U06958, AE001283, L39000, Z73423, U60136, AA547027, AI047966, AI272485, AA636308, AA529639, W18356, AA981268, AU020091 , AA408245, D19412, AA798747, AA412883, AA589964, AA154843, AA261703, AA575188, AA140300, AA415826, AA682109, AA139028, AA571923, AA517367, AA591578, AA412962, AI526343, W34370, AA097452, AA175157, AA408447, AA175185, AA656612, AI267112, AI592864.1, AI315140, AA139257, AI478927.1, AI566751.1, AI655849.1, AA628416, AI637656.1, AI342003, AA454157, AI138477, N94614, N92184, AA846238, AI292352, AI376851, H71118, AA047446, AI004357, H42483, AA934748, AI652351.1, W45047, R62724, AA373943, AA160181, AA946892, AA046636, AA833797, AI373725, R63679, AA370734, N64387, AA741383, AI635804.1, AA160180, H25877, AA836250, AI493682, AI470888.1, AA099298, AI560433.1, AA101822, AA884692, W79695, AA461483, AA620825, AI204540, AI589214.1, AA701559, AI089685, AA340350, C74979, AI022910, H69695, AA947863, N93509, H16775, AI075849, AI128109, AI379285, AA147393, AA748524, AI123660, T87406, AA425935, AA600922, AA669848.1, AA808885, AI630110.1, Z30155, N80449, AAl 15166, AA595321, T25976, AI420334.1, H90938, N62675, AA046055, AA813646, AA824587, AI024340, AI480039.1, AA120769, AA504327, AI198222, AI221564, AA069943, AI081089, AI129098, AI608732.1, N40801, AA676467, AA029559, AA609419, AA639021, N71966, AA847107, AI087243, AI126049, W96128, AAl 35241, N30829, AI579700.1, AI045768, AA495491, AU002110, AI555626.1, AI556515.1, All 75773, AA850988, AI058737, AI231585, H49000, AI104205, AI104061, AI579607.1, AI602655.1, AI012838, C22685, AI409652, AI172255, AA851526, AI101654, AI007826, AA848630, All 12250, AI172256, AI584197.1, AI626350.1, AI461286, AI035127, AU036743.1, 109267, 109270, 109268, 109269, 109252, 109251, A39595.1, A60955.1, A70359.1, A68104.1, A64973.1, A60975.1, A60210.1, A58525.1, 172268, 170384, 166490, 169298, 162993, 160241, 144531, A49949.1, A42847.1, E02293, E02431, E01024, 118795, A21895.1, A21625.1, A10360.1, A08457.1, A07700.1, A07699.1, A02228.1, 108776, A71440.1, AR000006, A63067.1, A58998.1, 172269, 170974, 166485, 166484, 166483, 163561, A49258.1, E02679, E02096, E01693, E01503, E01148, 128266, A23373.1, 115368, A29289.1, A24782.1, A04190.1, A02712.1, A02230.1, 109342, 101578, A58526.1, A58524.1, A58521.1, 186203, 166497, 166489, 160242, 158439, 144515, A39929.1, E02291, E02104, E00954, E00635, A27170.1, A28163.1, A27396.1, A25909.1, A20702.1, A20502.1, A18053.1, A13392.1, A10361.1, A10359.1, A08030.1, A05160.1, A00781.1, A13393.1, A70040.1, A65599.1, AR015960, AR007269, AR002333, A63064.1, A60990.1, A60211.1, A60209.1, 174623, 126930

SEQ ID NO:60

M55543, M55544, M63961, M80367, AF077007, AJ007970, U44731, M81128, AC006487, X77129, Z95388, Z78546, U06117, Z28127, X72016, U39487, Y10720, D10044, X92112, AL035640.2, AB020867.1, AI528561.1, AA122936, AA880099, AA174655, AA709608, AA139382, AA175795, AI386222, AI180927, AA153021, AA177644, AA833283, AA153027, AI007134, AA277123, AI036133, AA184762, W13273, AA050005, AA183500, AI194988, AA637915, AAl 14752, AI529783, AA591158, AA623124, Wl 1962, AA572614, AI226959, AA636826, W09157, AA656934, AA930058, AI196439, AI265579, AI507911, AA615757, AI255257, AA771075, AI196650, W14549, AI173439, AA537760, AA871548, AA623233, AA596947, W18580, W59642, All 16637, AA674847, AA871853, W09680, AA690356, AA690345, AA592134, AA929451, AA726211, AA815536, AA673795, AA575826, W08242, AI526861, AA871760, AA637894, AA796453, AI526944, AA871454, AA637995, AA726213, AA619507, AA792581, AA727850, AA710108, W10630, AI527364, W40592, AA882297, W74981, AA575817, AA530022, AA796572, AA727764, AA710331, AA756070, AA796620, AI265469, AA710332, AA871738, AA871524, All 18208, AA710753, AA518765, AA590563, AI255577, AI265458, AA727837, AI255565, AA871728, AA815514, AA876142, AI439472.1, W37973, AA075477, AA622193, AI492530, AI500511.1, W37755, AA642656, AI500507.1, AA837842, AA075671, AA587444, AA635989, AI285460, AA131850, AA937007, AA903286, AI251115, AI289455, AA533I56, AI084027, AA586545, AA627607, AA532369, AA579973, AA917383, T29528, AI138455, W72748, AI073859, AA471169, AA044192, AI683358.1, AI371522, AA424070, AA164464, AI683206.1, W01896, AA100063, AA305909, AA487528, AA354725, H05350, AA315174, AA827350, AA486849, F06345, AI081732, AI075062, AA937600, AA347633, AA650178, AA810201, AA131800, AA837672, AA424529, AA486850, AA044017, AI280597, AA834863, AA296543, AA487747, AA424397, AA610352, AA056488, AA564905, W77927, AA487367, W37972, AA337079, AI372935, AA587703,

AA911189, T87056, F07031, AA878690, AA873192, H05300, AI246407, AA576498, AA263171, AA296485, T83604, T75545, AI400402, AA294979, AA947554, F05698, AA158924, AA372968, AA506001, AA8480O4, AA582749, AA057242, AA665504, AI651570.1, F23076, F14838, F14828, AI626652.1, AI397188, AI411266, R65420, AA955194, AA494665, T43327, T41892, H36685, A57938.1, A62526.1, A62517.1, A62525.1, A62523.1, A62514.1, A62529.1, A60110.1, A34791.1, 161340, E02077, 122020, A61387.1, A34793.1, A34797.1, 191962, A34798.1, 102047, A57732.1, A30009.1, A30008.1, 161357, 155887, 136931, 122021, A23331.1, 161339, A34792.1, 151958

SEQ ID NO:61

AC004890.2, D44464, U69607, AC004287, AF022713, U65480, AF007190, AA023318, W34889, AI325217, AA020155, AI099015, W08125, AA171085, AA475225, AI428114, AV021511.1, AA530037, C81483, AI120505, W82682,

AU044036, AI550872.1, C81053, AI606072.1, AI482241, T58810, AA403044, AA404342, R51103, AA411125, H90789, AI656091.1, C01674, N46452, AI038763, AI125451, AA748144, R53731, R32580, AA336273, AI060054, AI412971, AI010977, AA817712, AA943539, AA945937, AA924941, AI575036.1, AI235973, AT000005, 108514, A52461.1, 115007, 140796, 140797, E08841, 176943, A22413.1, E08842, 140802, 140794, 176961, AR007335, AR007334, 140803, 159546, 140801, 140795, 140800, 140799, 140798, 140793, A22416.1, 140792

SEQ ID NO:62

AF062530, AF062529, Z98036, AC002098, Z66560, M20162, AC000396, AB012242, Z83001, Z73972, AF015725,

AB008267, AC004466, Z48305, X14710, AC005268, AI158210, AI607860.1, AI020516, AA734832, W82466, AA061808, AI585869.1 , AA929800, AA124107, AI464206, AI303901, AI270576, AA349855, H60027, AA639612, R25924, AI014725, AA092495, W58640, N55875, R14767, D21042, AA446652, AA086458, AA781029, AA629918, AI032793, AA573873, AA643067, R34884, AI654799.1, AA479474, AA0300I2, AA594551, AA838460, AA447455, AA148791, AA256802, AA150300, AA505932, W05069, AI493530, AI086076, AI289025, AI126256, N51389, AI435022.1 , AI652271.1 , AA701889, AAl 59318, AA404221 , AA504833, AA700625, Al 144326, H05385, H84256, AA404687,

AA096477, AI553943.1, AI590335.1, AA975658, AA836652, AA66321 1, AI366976, AA767837, AA836632, AI201421, F29452.1 , C 18263, AI420308.1, AA223701 , AA353488, X93835, AI436132.1, AA338652, AA835733, AA120828, AA313515, AA683145.1, AI179962, AI178673, Al 179961 , AA951467, AA736165, All 13962, AU033961.1 , H34335, AI388669, AI546326, AA950955, AF091037, AA056808, AA441103, 128420, 140904, 140899, 128996, 129683, 108242, 155123, E03428, 109285, E03204, E03201 , 117289, 117288, 130049, 182816, 143726, 108241, E03981, 108247, E02518, A51 133.1, 108243, E03202, E02829, 108244, E03203

SEQ ID NO:63

D13979, D14289, X79990, D14821, S78158, D32007, X79989.1, AF018282, AC007161.1, AC003006, AE000663, AJ224792, AJ011500.1 , AC005058, AF004221, K03329, Z70782, AF109907, X16300, M17293, D49507, AL034365, S55844, M13209, J02070, M17416, M57768, X67119, X16144, M80517, K01729, AJ224790, X01978, V01555.1, AU041415, AI604144.1, AA469776, AA469797, AI181996, AA125063, All 16642, AA764486, AA170124, All 19539, AI413228, AVO 18765.1 , AI591747.1 , AA645716, AA734228, AA245794, AA458335, AI420591.1, AI033811, H94855, AI167424, AI264845, AA904353, F02579, N75054, AA992855, R38996, N86959, AA247686, AI078840, F01701, AI080687, N88058, AA463390, AA095305, H46432, AA194741, AI476165, AA257797, AI574526.1, AI639156.1 , AA901073, AI640928.1, AA851803, 130202, A37267.1, E05655

SEQ ID NO:64

X79990, D13979, S78158, D14821, D14289, X79989.1, D32007, D14823, S78159, AF018276, AF018275, AF018283, D14822, AF018274, AF038029, AB010420, AB010419, AF018277, AB013280, AF052215, S74096, AF068266.1,

AF039200, AF069747, AF052210, AL034421.4, AF022978, L24038, AC002297, AJ005682.1, AC004011, AL022721.1, AE001039, AL008634, AJ005077, Z84466, X77694, AC001229, AA597034, AA261311, AA222011, AA674424, AI046358, AA222118, AI152215, AI606504.1, AA822901, AA914494, AA529559, AA015563, W89980, AI530389, AU044402, AA238326, AU046282, H18342, H18378, R91340, R70443, N75171, W39519, AA132116, Z39533, AI572746.1, AI683617.1, W38699, N71935, AI565447.1, AA450258, AI183938, AA099446, AI559642.1, AA758952, R40796, N73391, AI171652, AA996736, AI407074, AI176767, AA963424, AI169429, AA924939, 130202, A14660.1, 123902, 118688, 118460, 123917, 192571 , 192569, 113528, 192570, E12884, Al 1 181.1, Al 1 180.1, E12862, 123473, 168122

SEQ ID NO:65 AB012290, AJ224115, Z99128, AB006036, U92456, AF043288, AC005070, AF043289, AB017067, D13447, AL023634, AC005220, AB023037, AL021180, AB006605, AF002725.1, AF052290, AE000541.1, AL022311.5, AE001458, AA060080, AA492926, AU051027, AA864027, AI605657.1, AI595541.1, AI414590, AA537749, W12836, AA968079, AA062255, AI507200, AA863700, AA086829, AA230881, W17622, AU016791, AL048784.1, AA382461, AA21 1241, N28924, AI038250, W92175, AA428487, N23469, AI184192, AA553654, AI032748, AI127471, H98745, AI199780, AI200995, AI018139, AI247996, N35218, AI018413, AI000892, AI075315, W92176, AA479899, AA573426, AI248681, AA972378, AA971235, H37900, AAl 87099, H38682, AA935226, T69954, AI458606, AA526585, AA661672, AI626169.1, AI599584.1, AI555245.1, AI296396, AA891069, AI556934.1, AI165512, M88926, AA042641, AI163944, AI353541, R90536, AA497294, AI167032, D87223, AU060083.1, 126663, 126665, 119883, E08855, 109331, E03154, 162371, 109329, A49549.1 , 109328, 108294, 171894, 106440

SEQ ID NO:66

Z99128, AB012290, AJ2241 15, AJ005937.1, AC0041 16, AL023534, AI648020.1, AU020306, AU024203, Wl 1581, AA764641, AA097370, AI325483, AA024303, AI006140, AA798365, AA122933, AA450512, W36820, W08677, D19317, AI152339, AA408261, AA537961, AA869453, AI194970, AI385488, AA986211, AI573797.1, AA061055, AA821888, AI672149.1, AI126291, AA490202, AA629288, AA921804, R78142, AI076709, T77446, AA284106, R29335, R78141, AA323127, W25929, N76402, N77083, AA383402, N36259, AA373583, AI598063.1 , W73010, H26379, AA059466, AA915976, AI458262.1, N24536, AI034064, AI630968.1, AA899108, AI235699, AI210173, D24037, AA550072, C93780, AA965029, AI485592.1, AI490346.1, AA908042, AA926461, AI050201, AA952525, AI065367, 126663, 123446, A26668.1, E05206, A40099.1, AR022664, 131892, A51135.1, A40106.1, AR022657, A40098.1

SEQ ID O:67

L18880, J04126, Y00312, L13300, S52276, S52271, U66300, AF027174, U37573, AF039698.1, AF045432, Z97178, AJ010903, AF103726, U48696, U39066, AF032922.1, Y17148, Z49980, AJ004935, S78798, AF033097, AF061786, AF030515, AJ001103, Y15421, U34048, G29060, G29058, AF147449.1, S83098, U65376, AF033565, X99051, U52868, AF033096, AF079586, X99055, U44386, X65215, AF067624, X80164, U82828, U55724, S65693, S65694, AC007138.1, AF047564, X52256, S65683, AJ223292, S65686, X64409, X91233, AF027126, X70958, M22135, AC005026, AF147259.1, X99568, M80484, X65320.1, M24488, S83538, X65335.1, AI042965, AF093453, AA472473, All 15061, AA472598, AA457950, AI153412, AA881157, AA239775, AL048129.1, AA853564.1, AA471338, N84830, AA247827, N88782, H58760, N83993, AA093224, N83229, N83991, N55698, N84048, N89520, N84712, N87898, N84855, N88601, AA096046, AA095359, AA096066, N84718, AA095641, AA247964, N83168, N86694, N83992, N87989, AA095435, AA093577, AA096061, AA249353, N84781, AA249712, N88018, AA092086, N55721, N88518, AA093861, AA089553, N84765, N56555, N84829, AA215908, AA093897, N88496, N84828, N89307, N84740, AA093219, N561 18, AA093313, N84016, AA090302, N86439, AA089554, N84723, AA095511, AA215911, N84562, AA247828, N85031 , AA094237, N84602, N84733, N84875, N84921, N86441 , N56179, N84575, AA095475, N84721, AA096013, N55684, N55681, N55768, N84561, AA095921, AA095473, N84662, AA247800, N84764, N55669, N55700, N55641, N55659, N55697, N55639, N84859, N84874, N84722, AA249323, N85900, AA249064, N55653, N84873, AA248551, N84797, N85930, AA095919, AF041408, AJ241 143.1, AI483326.1, AI483209.1, AI354060, AI353169, AI617228.1, AI353694, AI483218.1, AI618568.1, AI618635.1, AI353159, AA660164, AI617432.1, AI617214.1, AA933363, AI616967.1, AA585825, AI616416.1, AI616808.1, AA933116, AU004045, AU004063, AU003308, C93848, AU061971.1, AU061862.1, W43681, AU012213, AU061926.1, AU062120.1, H07848, AI353413, AU061949.1, AU062001.1, AU062063.1, AU061924.1, AU061975.1, AU001522, AU001536, AA618732, AI066886, AT000691, C93682, A04374.1, A27635.1, 117659, 190252, E08428, A17373.I , E12149, A17374.1, AR009152, 148933, A17063.1 , E02958, A05144.1, AR007512, E08429, A14395.1, 132196, 124105, 108013, A29289.1, A25918.1, A25917.1, A08586.1, 159710, A45792.1, E08430, E04616, 128830, 115717, A14104.1, 118794, A26449.1, A05143.1, A17064.1, 124104, A33348.1, A22739.1, A22738.1, A23903.1, 115713,

A37288.1, E07853, A37287.1, A34041.1, A22736.1, A20700.1, 124701 , 177293, 125179, A33349.1, A20702.1, A71440.1, AR018093, AR018092, E12434, A50146.1, E02074, A22740.1, A21230.1, 143706, 148927, A42089.1, A18050.1, 170384, A26447.1, A29288.1, A21625.1, A13387.1, A13038.1, 106961, 105487, 107816, 192483, 183451, 183450, 185513, A46760.1, E02073, A17370.1, Al 1323.1, A01519.1, 115148, E12615, 138604, 124920, A13371.1, A10871.1, A02710.1, 105558, 109132, 190245, 146906, 144531, 124703, A13388.1, A29286.1, A23997.1, A21386.1, 166485

SEQ ID NO:68

Z50070, AC005405, AC006979.2, U80443.2, AJ005821, AV011931.1, AA218244, AI385712, AI462105, AI428532,

AA097078, AI120426, AA275245, AA871884, AI509894, AA168615, AA522413, AA222085, W36524, AA709795, W08491, AA500709, AI648883.1, AA039140, AA986882, AA163074, AA451366, AI325541, AI615295.1, AI481672, AI037075, AI662626.1 , AA684194, AI649000.1, AI591703.1, AU016270, AA667101 , AA734486, AV013533.1, AA125031 , AA476011, AA789350, AA497964, AI587926.1, AL048130.1, AL047646.1, AI564569.1, C06476, AI564600.1, AI583605.1, AA776250, AA564112, AA486728, AA458903, AA284505, AA744683, AA744677, AI041865, N35013, AI367320, AA478033, AA723251 , AI161355, AA521095, AA653613, AA173528, AA160880, AA653144, W72421, AA031689, AI095313, AA744691, AI243169.1, N27658, AA909152, AI381956, AA548423, AI240491 ,

AA150688, AA705238, W76280, H24935, AI290052, AA099284, AI003089, AI041158, AA299485, H47593, R8748I , H06272, AA670014.1, H62215, T92938, F32136.1 , W15223, H28559, AA045285, H57205, AA490932, R78919, AA165451, AI206471, AA370855, AA853565.1, T92716, H51597, AA831 147, H38452, T23463, AA776247, T93331, H97605, T92712, AA904909, R62767, AA568274, AA385864, AA814518, R71478, AA887917, AA833577, AA936405, T92721, R89767, R26297, AI240490, AA975607, AA975610, AA132058, T94009, R33615, AA719744, AI381794.1 ,

AA523772, T27752, AI675329.1, T55025, AA340520, AA640536, AA09053I , T54861, AA459097, AA564540, H99789, AI136460, AA900065, AI010678, AI230737, AI599236.1, AI105068, AI412135, AA955854, AI011 100, AA955166, AA597982, AI104512, E05646, A39800.1 , A39798.1, A58656.1, 109386, A37005.1, 134189 SEQ ID NO:69

X98494, Z83848, D87023, AC002060.2, AF036707, AF022981, AF125969, U76408, D87010, AF046084, AE000127, AF120927.1, U08110, AF046092, Y18000.1, Y14591, U53154, U85198, D87009, AF036359, AF028710, U65020, Y14592, U48809, AF057293, U90439, AE000661, U20857, U18428, L05251 , U10577, AF047659, U97079, Z93375, Z49908, M63783, AC005965, AC007061.2, S76016, Z68328, AL021107, X96469, Z73905, AF030052, AC004051, X16561, U67889, AL031652, S74622, AF025452, Z951 13, M37129, AC005927, U40375, AB026647.1, AB027513.1 ,

X06862, M60858, M17571, AP000076.1, X06856, AB011164, U58652, L05904, W75630, W64795, W33952, AA388279, AV020965.1, AV024242.1, AA822594, AA611358, AI666755.1, AI664403.1, AA217227, AA274596, AA667372, AI661115.1 , AI551976.1, W62996, AA103552, AA120182, AA675019, AA895561, AA183615, AI020280, AI666759.1, AA240412, W81743, AA178559, AI194355, AI159163, AA968004, C85953, AA259950, AI183094, AA013544, W18876, AA407843, AU023725, AI508428, C87289, AA061215, AA259498, AA030860, AAl 17303, AA268047, D18368,

AA414028, AA285757, AA821550, AI527508, AA967944, C86912, AA572380, W74843, AA848124, T24602, AA603307, AA159246, W73654, W01754, T92366, T93760, AI096565, AA159254, T90267, T90227, W26394, W28236, T92399, AA054682, AA329899, T92391, H99855, AA1311 15, W73607, AA147878, Z78377, AI080454, AA044888, W26028, T94225, T93759, T94254, T90230, AA166879, W27620, T93753, AA551443, T63911 , T93558, T94665, T90616, AI273114, T94922, W28045, AI070777, AI137651, C94041 , AI546038, L37652, AI406906, AI641607.1, R90246, T75711 , AA908051, AU062784.1, C46974, AI295651, AU060842.1, AI054913, AI296000, AU033967.1, D68715, C49179, AI443037, AI384793, C99888.1, AA958114, AI294740, C96722, AA950741, AA497303, AA495228, D36000, AA202384, AI044390, A1257069, AI514933, N83025, AA842900, D74159, AA952144, AI216940, U78748, AI253455, AI239345, AI539928, C09348, C43842, AA651326, AI437064, AI476857, AI548859, AA941414, C96769, D35760, C09488, C45265, AI102403, C49820, AU039361.1, AI043616, C44692, AU037725.1, AI540027, C83963.1, A50142.1, 155033, 187853,

A00764.1, 123464, AR013966, E12103, 128325, 171491, 119108, AR003567, 171490, 128591, 119102, A59205.1 , E06594, 123439, 191514, 138225, 180921, E05541, E05543, E08652, II 1571 , 109218, 168135, A46292.1 , II 1583, 168134, 109219, 112143, A22942.1, A45346.1, A30331.1, AR022373, AR022395, A30330.1, A32827.1 , A58691.1, A30354.1, E05544, 112142, E02506, A46291.1, 112873, 134431 SEQ ID NO:70

X98494, AI386428, AA162148, AA213194, AA881872, AI647220.1, AA590060, AI326008, AA619205, AI284853, AI222419, AA992199, AI681988.1, AA992130, AA025657, AI087795, AI263606, AA083314, AI094541, AA847842, AA731098, AA047545, AI420376.1, W80758, AA770202, AI357730, AA909134, AI271912, AA810790, N68965,

T97061, AI056034, AA668325, AA504113, AA347116, AI244315, AA837327, Z25156, AA888598, H88801, F00393, AI679289.1, AI679865.1, AI000365, H89025, T96950, AA916136, C02251, AI177638, AI406906, AA817668, AA901350, AI483281.1, 156746 SEQ ID NO:71

AF035606, U37573, U49112, AF082186.2, AF053408, X53937, AJ007829, AD001531, D50010, D78345, Y09813, U51113, L08785, U02430, M77811, U43955, U41513, AF053407, Y16359, U43957, U39779, U43956, U02437, U70311, X52326, L08786, U14119, L08784, L08787, U02449, U43954, L26977, U02457, AJ234771.1, L08783, AF053409, X52325, U01668, L08782, AF054625, M29362, U69698, X52324, M68946, AF 128862.1, Z29589, AF038666, M29363, X52331, AF053406, D61393, AF078810, X98363, X82190, AB015619.1, U14118, U14121, U14116, U84006, AF005420, AJ005339, AJ005324, AJ005323, U89927, L08874, Z32836, AFl 18920.1, U47102, AF041426, Z47173, U47103, X65334.1, X65316.1, X65314.2, X65306.1, Z47I59, X65315.1, U25268, U25272, AF092546, X65309.1, X65308.1, X65311.1, X65307.1, X65310.1, X65313.1, AF092940, X65304.1, U03442, U03440, U03435, U03438, U03436, U24178, X81969, D13509.1, U48696, Z97178, AF045432, U39066, AA855573, AA959713, AI646046.1, AI415428, AAl 16476, AI324822, C85464, AV012020.1, AU019447, AV028650.1, AV033871.1, W36252, AV044086.2, D7702O, AA213236, AI314599, AI314940, AI429791, AV033821.1, AI316230, AI573864.1, AI661543.1, AA254914, AI132558, AA168802, AA710186, AF093453, AI315071, AA881316, AI197054, AI256149, AI527428, AA238081, AI152451, AI132585, AA238390, AI121035, AI099353, W13766, AI157500, AA871944, AI132345, AA825538, AI522238.1, AI572080.1, AA831357, AI360561, AA775261, AI140796, AA835492, AI361820, AAI00279, AI277190, AI469550.1, AI015234, AA581345, D20022, AA122332, AI355770, AA485257, AA092467, AI471817, T34498, AI597962.1, AI624976.1, C14723, D57491, D55233, C16300, C16305, AI541540, AI526201, D61254, AI540858, AI557252.1, AI526143, AI526136, AI547006, AI557262.1, AI557271.1, AI556966.1, AI540876, AI546949, AI546984, AI557859.1, AI557866.1, AI541513, AI547042, AI541110, AI540926, Z28355, AA585101, AI541528, AI526059, AI541522, AI557850.1, AI525316, AI541541, AI525306, AI541523, AI541396, AI526150, AI526092, AI526198, AI557861.1, AI557863.1, AI546875, AI546896, AI546940, AI541530, AI546837, AI557856.1, AI541521, AI547171, AI525296, AI541390,

AI547116, T41289, AI547165, AI546999, AI547080, AI547147, AI525431, AI541537, AI546917, D57186, AA174170, AI525500, AA585439, AI541374, R29177, AI525204, R29218, AI541535, AI526045, AI557731.1, D53447, AI557799.1, AI525556, C16293, AI541307, C15069, AA660699, AA751703, AI058193, AA441129, AA695353, AA696974, AA821091, AA816610, AA697069, AI021792, AA694821, AA696904, AA803031, AA695217, AA802872, AA753798, AA802568, AA751523, AA696639, AA698105, AA525623, C94908, AA754494, AI215223, AI374340, AI215263, AA751866, AA751952, AI374376, C06511, AA754497, AA751691, AA752525, N98067, AI563441.1, AA525581, AA052885, AT001210, AI215226, AA751833, AA751907, AI507946, AI563445.1, AA803406, AA735727, AI215264, AI215215, AA751591, AA751592, AI096152, AI215210, AA752541, AA695930, AA697684, AA802970, AI374225, AA754313, AA750210, AA751934, D43391, AA694838, AA735768, AA697195, AA698716, AA750248, AA080594, AI021791, AA539955, AA751578, AA752036, AA750187, AA751554, T00697, AA751859, AA696794, F20138, R46884, AI180308, AA956495, AA753213, AA819488, AA818950, AA851164, AA439637, AI014075, C06771, AA751850, AA752256, AA752020, AA566697, AA961326, AA754338, AA751678, T24259, AA080579, T15066, AA751446, AA754399, AA751589, AA754496, 118794, A25909.1, 169323, 169324, 163120, A20702.1, A43188.1, A20700.1, A43189.1, 184553, 184554, 105558, A64973.1, 170384, E03627, A60210.1, 106859, A18050.1, 148927, A60111.1, A60211.1, A23633.1, A02712.1, A60212.1, A18053.1, AR007512, A23334.1, A60209.1, 113349, A10361.1, 149955, Al 1178.1, E01007, E13740, Al 1624.1, E00609, Al 1623.1, 100682, 138604, A70869.1, 144681, A04664.1, A02196.1, A35536.1, A35537.1, A04663.1, A02195.1, A58522.1, 162368, A13393.1, A13392.1, A02710.1, E12615, 103331, 144516, A70040.1, 121869, A07700.1, 128266, 144531 , 149890, 113521, A27396.1, 152048, 121170, A58523.1, 115717, 115718, A58524.1, A24782.1, A24783.1, Al 1245.1, 118895, 133154, A70872.1, 108396, 108389, 108051, 160242, 160241, 126927, 126930, 126928, 126929, 125027, 101995, 144515, A22738.1, 166494, 166495, 166487, E00697, E00696, A20699.1, 109126, 185655, 185653, 108395, 105845, A22734.1

SEQ ID NO:72

AF035606, U49112, AC004485, U73627, AC000389, AEOOl 146, D89223, AC004923, AC000385, U03396, Z95397, AI324822, AA959713, AAl 16476, AI415428, AI646046.1, C85464, AV012020.1, AV028650.1, AA855573, AU019447, AI314940, AI429791, AI314599, AI316230, AI573864.1, AI197054, AI661543.1, AA881316, AA825538, AI522238.1, AA831357, AI572080.1, AI360561, AA775261, AI140796, AI361820, AA835492, AA100279, AI277190, AI469550.1, AI015234, AA581345, D20022, AA122332, AI355770, AI471817, AA485257, AI597962.1, AA092467, T34498, AI624976.1, AA089786, AA323239, N66311, AI583131.1, AA235383, AA749042, AA424515, AA918245, AI251010, AI492326.1, N21277, N75967, AI538241, AA747919, AA836065, AA555024, AA829834, AI292114, N32584, AI291299, T06835, AA851164, AA819488, AI014075, AA818950, AA956495, AI180308, AU060744.1, AI411437, AI137403, AI408578, AI230355, AI411858, 157316, Al 0265.1, A07704.1, 182512, A26415.1

SEQ ID NO:73 AF089816, AF032120, AF089817, AF089818, AF061263, AF104358, AA396587, AA839164, AI645842.1, AA259652, AI462731, AA396061, AI508747, T25830, W06974, AA300306, AA158704, AA702414, AI335709, AA974969, AI193578, W87364, N39553, AI669881.1, AI424712.1, AA513461, R10174, AA565967, H25130, AA468577, AA367767, AI418022.1, H49150, AI369600, T52003, AU056473.1, AR012064, 187064, 184560, 165545

SEQ ID NO:74

AF028824, AF089816, L38482, AEOOl 104, AL033502, AC005757, U34830, AC004076, Zl 1490, AJ222796, AL022069, Z75543, AC006056.2, AC006508, AA285636, AA711082, W64914, W20880, AA172932, W09810, AA793773, W62886, AV026607.1, W18328, AA734581 , W53794, AA674963, AA175523, AA222652, AA286301, AA067058, AA727901, AA692352, AA608460, AI429553, AA216860, AA163431, W97171 , AI286788, AA450721, AA273318, AA267167, AA203863, W98132, AA733321, W61471 , W10683, AV042841.2, AI662163.1, AA691246, C76145, AA597140, AA178040, AV041261.2, AA929100, AI586270.1, AI324366, AA512291, AA638455, AA217257, AA138312, AV040396.2, AA869209, AA822151, AA710587, AA689043, AA178370, AA152940, AA122810, AA571067, AA529128, AA276820, W53574, AA175721, AA146102, AA137743, AI528673.1, AI504720, AI464870, AA616238, AA183539, AA172429, AA170209, AA145390, AI325168, AA616060, AA267185, AA139433, AA125142, AA688934, AA689641, AA267963, AA221937, AA220370, AA170764, AI530662, AA733250, AI660895.1, AI472081.1, AA781474, AI073909, W73036, AI032395, AA581812, AA149940, AA535595, AI085734, AA666165, AA579893, AI624402.1 , R32110, AI241188, N64621 , AA740666, AI589363.1, AA677956, AI343472.1, AA878576, AI634734.1, AI423229.1, R50716, AI683679.1, AA705739, H64249, AI272198, AI654473.1 , AA325291, AI672928.1, R40181, AA612759, AI499113.1, AA404606, AI270050, AI056166, AA995431, AI289585, T54484, AI218312, AA918644, R33590, R32109, T30333, R09164, R77191, AA404222, AA304135, R33694, AA160211, AA320369, AA135772, AA135729, AI392813.1 , AI370449, W73301, AI298917, AA160212, T16203, AA434159, N78888, AA295659, T48755, AA887316, N55776, AI245392, AI366949, T25831, AI278660, AI364244, H64248, AA150525, N79950, R09267, R80211, AA157962, T73936, AI597799.1, R98601, AA374943, H50728, AI298607, AA423820, AA622465, AI569836.1, R55012, H44307, AA282809, AA419079, AA206818, AA371801 , AI090123, AA506994, AI298776, AA436972, T82181, F22959, AI228589, AI013903, AI562315.1, AA697640, A70195.1, 125849, 178457, 162859, 108631 , EO 1324, 108638, 115551, 107396, A44968.1 , E08433, 142577, A68700.1, E01495, 168738, A08267.1, A45357.1, A46785.1, A23164.1, A42378.1, A45334.1, A08269.1, A65720.1, AR022391, 180845, A45372.1, AR022409, E06904, A46718.1, 114085, AR022411, 112883, AR022381, A08862.1, 113029, 150851, A46720.1, AR022410, A45340.1, A70680.1, 180847

SEQ ID NO:75

X03205, U13369, M10098, K03432, X82564, X00686, Ml 1188, X011 17, V01270, X06778, 01593, X00640, D84514,

X04025, X59734, M97576, X59733.1, M91180, AFl 15860, X02995, J00999, K01373, X98843, M91 182, M91181 ,

M91179, M91183, X98841, X98846, LI 1288, X98844, AF102857, U87963, X98840, X98837, D50494, X98842, X98838, X98836, X98839, X98845, AF030250, M33066, M59402, L24123, M97575, M59384, M97573, M59393, M59401,

M59392, M59386, AF021880, M59385, M59391, M59387, M59399, M59397, AJ007613.1, L81946, X70210, AJ007614, U50968, AF062955.1, U08333, X81631 , X80233, U08327, LI 1230, LI 1266, LI 1270, U93555, X79877, AF025946, U36271, AF062954.1, U19519, AF062950.1, X91974, U12647, LI 1269, M59388, M59396, AF062964.1 , AF062947.1 , X87985, U88337, LI 1267, AF103730, AF099943, LI 1268, Z83753, Z80955, AF021879, AF099942, U08325, U08331, U08329, M59390, U67324, AA409121, AU023662, AA407434, AU020382, AA409846, AI256506, AA914790, C86941, AI132252, AU035733, AU021041, C87199, AI322276, W20927, D19503, AI324724, AAl 14639, C88357, AA895334, AI546975, AI547168, AA090106, AI547131, AI524874, F29913.1, F27302.1, F24428.1, AI547125, AI547156, AI547139, AI547184, AA215893, AA092005, AA247334, AI557155.1, F27796.1, H43062, AI547170, AA585468, AI540955, AI547195, AI547112, AA248417, U46270, AI547189, AA094658, AA336280, AA095372, N25575, AA502901, AA360125, AA360124, F34726.1, AA669617, AI032872, T29140, AA369101, AA585173, AI554412.1, AI635062.1, H46573, AI289938, AI283315, H42931, AA506222, N86367, AI354556, AA532838, N88979, H50362, H45047, AA094430, AA346313, U46222, H41656, H26440, AA095425, N44063, F29193.1, AA728882, AA715534, H18223, AA725242, H23882, AA911513, AA714262, AA809098, AA074261, H26690, AA360197, T94543, AA092500, AA484257, H96223, AA378312, AA318469, AI452940.1, AI547166, AA093380, T93007, AA481974, AA300605, H18966, AA361972, AA515044, AA569231, R82750, T82440, H52350, AA455819, R71893, AA728869, AA744120, AA360304, AA713764, H52327, AA378126, AA828929, H61354, AJ241 168.1, AA900286, AI058227, AA850573, Z71889, AA991117, AI230423, AI408809, AI407879, AA850888, AA850889, AA944702, AI058228, AI008416, AI083253, AA228229, AA052022, AA2731 17, AA057965, AA598354, AA545824, AA598355, AA280468, AA022350, AA570908, AA430839, AA224630, AA842564, AA257199, AA232024, AA253533, AA991043, AA514179, AA570837, AA056804, AA253514, AA406738, AA471543, AI087484, AA257416, AA056821, AA280496, AA990956, AA585660, AA224628, AA080798, AA842506, AA273099, AA246088, AA023868, AA471501, AI105694, AA022420, AA514160, AA675823, AA231991, AA051980, AA661367, AA842135, AA598367, AA052055, AA433431, AA471489, AI083303, AI058023, AA417401, AA570918, AU000884, AU001347, AU000812, AU001068, AU001611, AU001774, AU000888, AA570916, AU001817, AU001353, AU001781, AU000838, AU000775, AA052026, AU000916, AF091041 , AU001977, AU000763, AU004020, AI082942, AA570824, AA228228, AI087453, AI629970.1, AI621757.1, AI621756.1, AA480713, H52877, AA651576, AA991088, AA471400, C95447.1, AA228160, AR022116, A07562.1, A70359.1, E01321, 169485, 109303, 127617, 169461 , A21385.1, 158610, AR015960, E01508, AR000007, 158595, 165402, AR000006, 108115, 116573, AR015961 , 190051, A49389.1 , E06998, 116572, 158596, 158609, 185654, 185656, 172268, A33044.1 , A67356.1, A57359.1, A67368.1, A67338.1, A67269.1, A67359.1 , A27396.1, A67336.1, 126929, A67265.1, E07334, 179228, E08821, A48778.1, A48781.1, 114456, 114452, 114455, 114450, 114453, 114451, 114454, 133579, A51866.1, A67262.1, A67300.1, A67291.1 , A67267.1, 192570, 118898, A22424.1, A39827.1 , 126928, A02365.1, 140369, A48775.1, 167829, A48776.1, E01246, A63774.1, A63776.1, 168031, E12844, 114936, 125006, 136197, A63954.1, E01510, A58741.1, A48774.1 , ARO 19620, 116901, 140370, E01315, E01316, A58742.1 , 160004, E07337, E03076, 162976, 189769, A48779.1, A48782.1 , 160003, A58738.1, A58740.1 , AR022119, AR0221 18, AR022117, A60858.1 , E03345

SEQ ID NO: 76 AI477953 SEQ ID NO:77

MK3710/T3 5', AF025438, AL024458, AC005539, X79080, Z48544, AC004455, AC005966, U63928, AC004680, AA137279, AA541923, AA000683, W10638, W43974, AA000401, AA003291, AI461713, AA637410, AI585560.1, AI430072, AA759800, AA546383, AA607321, AAl 10039, AU024430, AA959647, AU024429, AU022981, AA600493, AI430557, W15850, W58718, N32746, AA024784, AA313566, AA236836, AA007319, R72404, AA236656, AI090162, AI630438.1, AA701988, AA852227.1, AI337332, AI630424.1, H30501, R17187, AI304319, AA236789, H25699, N56244, AA865602, AI631687.1, N66532, AI076924, AA452088, AA916723, AA024685, AA007455, AA916358, AI336121, AA521369, AI167263, AI283104, AA345744, AI140745, AA451907, AA995467, N23163, R77800, AA505618, AA913049, AA385531, AI538205.1 , AI073755.1 , AI352390, R72405, R41738, AA670386, AA334614, AA228391, AI625253.1, AI637995.1, N70197, AI648548.1, AA148868, F08701, AA216042, AA358819, H35482, AA687041 , AI599140.1, AI171338, AA979853, 123866, 127840, 127838, 108198, 140308, E05224, 185624, 127866, 127845, 127844,

127842, 127841, 195863, 127839, 138154, 127837, 127830, 127829, 168296, 168289, 132039, 107691, 103244, 101972, 105124, 107865

SEQ ID NO:78 AF025438, U42838, AL031055, AL024458, AB009052, D17798, AB005234, AC000389, Z92844, AL032654, Z68335, DI7799, AC004680, D17797, AB006621, AC007478.1, AC004455, AF043644, AI337332, AA236789, AI304319, AA701988, AA865602, N66532, AI631687.1 , AA916723, AA024685, AA916358, AI336121 , N23163, AA007455, AI167263, AA451907, AI283104, AA995467, AA505618, AA913049, AI073755.1, AI538205.1, AA670386, AI352390, AA680352, AA720562, AA723980, AI081040, AA992256, AI267913, AA532854, R41738, AA928158, AAO 16221, AA345744, R72405, AI140745, AI079153, AA852226.1, H89982, AA385531 , AI539552, AA236836, N50079, AI090162, AA858049, AI678339.1, AI678340.1, R77800, AI198148, H30501, AA024784, T26930, AI630424.1, AI630438.1, N32746, W58718, AA313566, AA765777, R72404, H25699, AA827898, AA828343, R16194, AA620328, AA731868, AA807325, AI122832, AA883479, AA906396, AI082866, AI128465, AA443098, AA478302, N22400, R62948, AI683470.1, T36141, AA382667, AI218567, Z40072, AI028209, AA706681, AA007319, AI022083, W87682, AI131464, AI624085.1, AA835706, H68927, R33458, AA280829, H02184, R76465, R79700, F03294, AI076924, AA515913,

AI461713, AA637410, AA546383, AI585560.1 , AA541923, AA959647, AU024430, AU022981, AA137279, AA607321, AU024429, AI505865, AA000683, AA165954, AV037726.1, AI462603, AI414233, AA675510, W10638, C80158, AA396049, AA589236, AI427115, AV044619.2, AU018321, AU042469, All 17767, AU042619, AI599140.1, AA924460, AA963706, AI007935, AA801012, AI103628, AI232289, AA998746, AI177518, AI599208.1, AA140989, AA140898, AI229404, AI112065, AI532103, AI512758, D75940, AA098741, 123866, E05288, E06690, E03372, A06409.1, A46255.1, 115824, E13276, 140308, A58268.1 , A40116.1, E07277, 134427, 185624, A28104.1, E05467

SEQ ID NO:79

AJ010841, AF045432, AF103726, S78798, AJ004935, U48696, AJ010903, Y17148, Z97178, AF039698.1, U66300, U37573, AF032922.1, U39066, AF027174, AF030515, Z49980, AF033097, AF061786, Y15421, AJ001103, G29058,

G29060, U65376, AF033565, U34048, U52868, AF147449.1 , AF033096, S83098, X99051, U44386, AF079586, X65215, X99055, X80164, S65683, S65686, S65693, S65694, AJ223292, X65335.1, X99568, X70958, S83538, M24488, X64409, M22135, AF027126, X65320.1 , M80484, W73086, AA307154, W58564, AA363862, T06444, AA452335, H78479, R63123, T36308, Fl 1379, H59799, W15560, N76641, T83390, F07471, T83556, N24488, H17884, AA293188, AI541284, T10785, AA157103, W01696, N89520, H58760, N88782, N83991 , AA247964, N83168, N83992, N84048, AA247827, N88601, AA096046, N84855, N84718, N83993, H96310, AA095359, N84712, AA471338, N86694, W23637, N84830, AA096066, AA093224, AA095641 , N55698, R84921, N83229, AA093861, N88518, N87989, N88018, AA249712, AA089553, N87898, N56555, N84829, AA215908, N88496, AA095435, N84828, AA247965, N84781, AA093897, N561 18, AA093577, AA092086, N89307, N84016, N84721, AA096061, AA249353, N55721, AA089554, AA094237, N84602, N84723, N84733, W14808, AA124189, AA423088, AA086801, AI121283, AAl 19742, AA222785, AA985756, AA218282, AA711181 , W33933, AA815685, AA273544, AA238334, AA000754, W90901, AI316625, W85535, W36243, AI595622.1, AA050409, AA106608, AA217769, All 19458, AA390040, AA879757, AA879644, W57189, AA220693, AA120515, AA623076, AA939357, W16243, AA914937, AA009010, AA674174, AA536703, W76881, AA667299, AA048263, AA066010, AAl 17786, AA561056, AA172553, AA177257, AA929573, W16154, AA198255, AA833367, AA822615, AA140412, AA049167, AA545088, AI561434.1, AA212687, AA222090, AA867450, AF093453, C82658.1, C83514.1 , AF041408, AI483326.1 , AI483209.1 , AI354060, AJ241 143.1, AI617228.1, AI483218.1, AI353694, AI353169, AI618568.1, AI618635.1, AI353159, AI617214.1, AI617432.1 , AI616808.1, AI616416.1, AI616967.1, AA933116, AI617405.1, AA866363, AI353413, AI353166, AA933363, AA660164, AI483120.1, AI483354.1, AI353794, AU061862.I , AA660165, H07848, AU061924.1, AU061949.1, AU062120.1, AU062001.1, AU062063.1, AU061975.1, AT000691, AU001522, AU001536, AU061926.1, AU012213, C93682, AU061971.1, A04374.1, 117659, A27635.1, E08429, 115717, A08586.1, E08428, A22739.1, AR007512, 124104, A22738.1, A29289.1, A25918.1, 124105, A23903.1, E12434, Al 1323.1, A21230.1, E08430, E04616, 128830, A34041.1 SEQ ID NO:80

AJ010841, AC005666, AC005393, AC005972, AC004099, AC002472.2, AC004381, AC004950.2, AL009031, AC002326, AC005899, AC005844.7, AC005216, AC007406.1, AC005684, L77570, AC003687, AC005509, AC005516, AC004601, AC004461, Z49154, AL022159, AC002420, AL021327, AC005297, Z99128, U73643, AC005726, AC007025.2, AC004812, AC005034, U91323, AJ011930, AC004677, AC005332, AP000019.2, AC002036, AC006111, U07000, M31758, AC004033.3, L02935, AC005921.2, AC006116, AC005409.1, AC004861, Z95326, AL034427, AL020997, AC004496, AC002303, Z81364, AC004525, AC002070, AC004584, AF044083, AC007228.1, AFl 11168, AC005668, AI074462, H99205, AI038375, AA299728, AA732982, AA602488, AI345497.1, AA570441, AI371278, AA487512, AA491864, AA614595, H70245, F25696.1, AA602468, AA618392, AA306530, AA618346, H66503, AI610602.1, AI370302, AI285709, AA620386, AA708669, AA362670, M77904, AA338281, AI375374, AA515254, C87864, AA501262, AI503861, W62377, AI174175, AI425687, W51648, AI430519, AA608054, AU043654, AA125170, AU019533, AU018489, AI042727, AA606504, W82457, AI413410, AI272569, AI666697.1, AI464637, AI503850, AI326216, AI604686.1, AA4091 16, AA546569, AA764359, AA414514, AI536524, AA245852, AA516955, AA675385, AA647434, AI506364, AU015379, AA501128, AI648194.1, AI585444.1, AA815851, AA435259, W77222, AA521969, AI066909, AI539956, AA107123, H39328, H39389, AI228245, AA550283, AI151560, AI218793, AI145414, W06387, H39351, AI601645.1, AI626190.1, AI235890, AI437130, AI411411, AA944647, AA817940, AI234683, AA753253,

AI044039, AI010110, AA751823, AR020909, AR003505, 174786, 116884, A67424.1, 109371, 159642, 155948, 176960, A42329.1, 145974, AR007159, 181226, AR007160, A52294.1, A62731.1, A47886.1, 117291, A12032.1, 108101, 108711, A65971.1, 138533, E12183, 119138, 122241, 173182, 128360, 122254, AR014241, 140899, 196182, A51135.1, AR008154, 140904, A51133.1, 141409, 134189, 108667, A62791.1, 173181, A62929.1, A47885.1, A28928.1, 125678, AR016035, 140908, 193602, 131750, E03829, 107993, 171461, A58884.1, E03350

SEQ ID O:81

AF039218, AF086824, U39904, AF070066, AC004811.2, AC002563, U48696, Z97178, U39066, AF039698.1,

AF032922.1, AF033097, S78798, Y17148, AF103726, AJ004935, AF045432, U66300, AJ010903, U37573, AF027174, Z49980, AJ001103, U34048, AF061786, AF030515, AF 147449.1, G29060, G29058, Y15421, X99051, AF033565, U65376, S83098, U52868, AF033096, AF079586, X65215, X99055, X80164, U44386, AL022326, S65693, S65694, S65683, S65686, L09233, AJ223292, AC005088.2, AF030453, Z75543, X70958, X65624, M22135, AF027126, AF092090, M22462, X59046, X99568, X64409, M24488, X65320.1, X65335.1, S83538, M80484, AC000378, AF063424, N88018, AA095435, N83992, N83168, AA095359, N84855, AA095641, N83991, AA249712, AA096066, N88782, N84718, N83229, AA247964, N88601, AA096046, N89520, H58760, N84781, AA092086, AA093577, AA247827,

N84048, N55721, N86694, N55698, N84712, AA471338, N83993, N84830, AA249353, AA096061, AA093224, N87898, N88518, N84765, N87989, N84829, AA093861, N89307, N84740, AA089553, AA093313, N88496, AA215908, N84828, N56555, AA093897, AA093219, AA095511, N56118, N86439, AA095475, AA090302, AA095473, AA096013, N84016, AA089554, AA095921, AA247965, AA247828, N84562, N84921, AA215911, N84723, N84575, AA247800, N86441, N84602, N84733, N85031, AA094237, AA093340, N56179, N84721, N55768, N84716, N84859, N84561, N55681,

N55684, N55700, N84662, AA093327, N84875, N84743, N84874, AA095934, AA095931 , N84920, N84764, N55669, N84719, N84797, AA249317, AA096034, AA249323, N55641, N84759, N84731 , N55697, N84734, N84557, N84735, N84767, N84796, AA968035, AI510359, AA107365, AA177241, AAl 16487, W62286, AA048139, AI662626.1, AI510013, AF093453, AI414276, AA793624, AI426165, AF041408, AJ241143.1, AI483326.1, AI483209.1, AI354060, AI353169, AI617228.1 , AI353694, AI483218.1 , AI618635.1 , AA660164, AI618568.1 , AI353159, AI617432.1 ,

AI617214.1, AA933363, AI616967.1, AA140828, AA660165, T18197, AI616808.1, AA933116, AI616416.1, AU065197.1, H34782, AA202074, AI171924, C28274, 117659, A27635.1, A04374.1, A29286.1, A71440.1, Al 1323.1, 183451, 183450, E12434, AR018093, AR018092, 175052, 105558, AR013726, A37287.1, 124703 SEQ ID NO:82

AB023166.1, AC002563, U93872, AL031684.11, U75698, AL034404, D26124, AC004506, AF042091, L32592, S68330, U05855, X58358, M86609, S68290, M33376, U05684.1, H10788, AA308642, N57796, T91324, W42440, N57810, R50756, R44891, H79564, H63135, AA353105, AA224531, AI245941, AA778789, AA379967, AA677294, AA617920, AI183534, AI017868, T64355, N78070, AA349149, F06821, N95101, T18490, AA426495, H64052, H45786, W00508, AA443253, AI337047, AA456531, AA546601, W78614, AA822334, AI509701, AA177442, AA881661, AA104861, AA957183, AI228556, AI102448, AA955912, AA753307, 132609, 132608, 109500, 181152

SEQ ID NO:83

Z36816, X82322, AB018295, Z50112, U91320, Z82205, Y13095, AC004738, Z78419, L14020, X54660, Y14051, AC004830, L14017, Y13096, X63598, AA088822, H50443, T65364, AAl 12796, Fl 1994, Rl 1879, AA075824, AA363903, H19785, T65515, R55598, Fl 1904, AA742633, T08516, T16871, W21846, AA053446, Z45691, F08352, AA018126, R09436, N91137, AI371352, R45445, AA707531, AA922035, R16064, H10898, AI522333.1, AA317592, AI042452, AI280625, AI679950.1, AA995402, AI475240.1, T29160, AAl 56317, AI282699, AA620367, AI570366.1, AI677936.1, AA868180, AA024629, AI625587.1, AA896188, AI197257, AI591958.1, W85360, AA517314, AA184178, D28616, AA000364, AA739011, AI153477, D21680, AA032616, AA027649, AA895817, D77943, AI195080, AI410833, AA965117, AA264673, EOI 143, 105978, 107630, 109160, 108646, A00367.1, 183400, E01141, A47497.1, 108512, A47505.1, 105982, A00368.1, 104859, A47500.1, E01817, 108375, E02975, EOI 142, 108513, A37282.1 , E02287, 195525, 132037, 132039, 150038, E03805, A09701.1, 132036, 140899, 132038, 132035, A68194.1, 101424, 165799, 140900, 150036

SEQ ID NO:84

Z36816, AC006075, Z54328.1, Z83849, X82322, Z50112, Z82205, AB018295, AC003034, U91320, Z93242, Yl 1769, Y13095, AE000895, U89337, AC004738, L14020, X63598, X54660, Y13096, AC005940, Y14051, L14017, H50443, AA088822, T65364, AAl 12796, Fl 1994, Rl 1879, AA075824, T65515, AA363903, R55598, H19785, Fl 1904, AA742633, T08516, T16871, F08352, Z45691, AA018126, W21846, AA053446, AI254622, T31811, R45445, AA707531, N91137,

AI371352, AA922035, H10898, AI341327, AI522333.1, AA317592, R16064, AA896188, AI197257, AA517314, W85360, AI591958.1, AA184178, D28616, AA000364, D21680, AA739011, AI153477, AA032616, AA027649, AA895817, AI592661.1, AA184644, AA275926, AI508824, AI195080, AI410833, AI397934, AI329440, AA264673, AI328274, AI330046, AU014161, 108646, 105978, E02287, A00367.1, A00368.1, E01817, A37282.1, 108513, EOI 143, 107630, 108375, A47500.1, A47497.1, 105982, A47505.1, E02975, EOI 142, 109160, 183400, 104859, 108512, EOI 141, 195525, 100302

SEQ ID NO:85

AF035296, Z70685, AF038149, Z73987, X55146, AI433239.1, AI017541, AI143057, AI129967, AI084109, AA629401, AI032340, AA775878, AA134114, AA088684, AI537873.1, AA709474, AA052969, T17399, AI198524, AA455953, AA662286, T65434, N23103, AI500354.1, T77285, R48306, T87060, T16870, AA242771, AA364661, AA725410, AA888835, R48408, R55361, AI383126, AA772585, R17756, R53154, AI468078.1, T83615, AA740428, AA989632, AA776777, AA970686, F09551, R84473, AA053446, R40543, AA242901, W21846, AA485133, AA281393, AA232269, AI370430, AA224090, AA347756, R41107, W05481, AA275082, AA855630, AA220284, AI463984, AA463077, W82555, AA073785, AI324193, AA154075, AI182915, AA106802, AA014261, AI639626.1, AI152571, AA646606, AI506180,

AI507257, AI429182, AI606877.1, AA924764, C47439, C39222, C59098, C50045, C41623, R62041, C08663, AU003527, A58088.1, 153742, 109510, E07649, 109483, 153740, 109479, 158691, A47294.1, A14416.1, 143649, 143650.

SEQ ID NO:86 AB009048, AB025608.1 , AB023029, D45408, U66525, AJ001535, AB008265, U92032, U64851, AF040653, AL031466, AJ001088, AEOOl 119, U28760, AL022159, Z66567, AA911802, AI002480, AI194910, AI553588.1, AA002743, AI605067.1, AI507141, AV047448.2, AA144114, AI048158, AA027393, AV045119.2, AI616016.1, AI593489.1, All 14364, AI103519, AF072311, AI104101, AI043643, AI172153, AI170369, AA850229, AA963983, AA943102, AA964030, AI178450, AI180267, AI444084, AI670492.1, AA866229, AI102852, AA997446, AA819921, E03424, E01085, 138466, 157017, 150752, 128766, A52373.1, AR002611

SEQ ID NO:87

AC006014.2, AL021492, AB006703, AL021407, U69552, AC004705, AL035652.5, M86602, AC007451.1, AF003389,

U66404, M87645, AB018302, AB008894, D10388, AL031986.1, AF107885, AF100306, M81324, U67494, U71250, AC004848, U09099, AI652638.1, AA505930, AA991355, AI141264, AA404284, AA256257, T81922, Z44433,

AA418204, HI 1780, AA906203, R13493, AA626308, R21616, AA627829, H67699, N72268, AA483210, AA705542, AA836379, AA399099, T06701, H99959, AA886062, AI498087.1, AI129945, R22315, N78414, AAl 13241, AI124535, H58271, AI643503.1, AA445695, AA673655, AA104978, AV034590.1, AI551985.1, AA142747, AI046551, AI020135, AI603873.1, AV035454.1, AA560196, AV037887.1, AV034119.1, AA522204, AV034487.1, AI594423.1, AI467549, AA615061, AA536264, AA391903, AA536375, AI545190, AI394892, AA497287, AA852029, AI179945, AI621492.1,

AA141341, AI395360, AU030825, C62664, AA894271, C61515, AI544602, AI484773.1, AI544587, H32027, AI601838.1, AA392665, AA494567, C61354, AI138116, AU002819, A16299.1, AR023861, 158691, 185760, A63216.1, A64062.1, 162852, 178753, A22884.1, A22882.1, A68351.1, A22732.1, 165400, 160419, 196204, 124761, AR023856, 125974, A68348.1, 109386

SEQ ID NO:88

AFl 16910.1, AF033097, AF103726, U48696, AF027174, AF045432, S78798, U39066, U37573, AF032922.1, U66300, AF039698.1, AJ010903, AJ004935, Y17148, Z97178, Z49980, AF030515, AJ001103, AF061786, U34048, AF147449.1, G29058, G29060, Y15421, U65376, S83098, AF033565, U52868, X99051, AF033096, L22858, L33180.1, X99055, X71415, Z83744, U44386, AF079586, L35905, AB025632.1, X78287, Y14344, X65215, AA460045, AA093577, N84781, AA095641, AA247827, N84830, H58760, N88782, AA095359, N84048, N86694, N84712, N84718, AI681138.1, AA263076, AI678836.1, R66162, N84892, R59232, AA722287, AA543176, AA153374, AA144562, AAl 14761, AA549506, AA623764, AA797275, AA199399, AA461807, AI035692, AI267040, AV009982.1, AA982653, H34369, AF041408, AJ241143.1, AI483326.1, AI483209.1, AI354060, AI353169, AI353694, AI617228.1, AI618635.1, AI618568.1, AI353159, AI483218.1, AI617214.1, AA933363, AI617432.1, AI616967.1, C72137, AI616808.1, C84814, AI616416.1, AA739596, A48542.1, AR014186, E02819, 107068, 112528

SEQ ID NO:89

AFl 16910.1, AF060568, AF016679, X52871, U51999, M15387, AF099810, U96131, AE000092, AL035427.17, D87952, AF088189, AC006216, AA827562, AA514488, AI190270, AI539185.1, AA778031, AA083889, AA255533, AI539830.1, AA532881, AA459956, F19104.2, AA749416, AA247961, N66268, AI630888.1, AA255505, AA384265, AA364111, AA729375, AA702934, T06791, AI673094.1, AA559086, AA331632, H87048, AA876414, D62684, AA203356, AU042596, AA271691, AA538198, AV008608.1, AA711797, AI159057, AA120508, AA739069, AV038838.1, U94841, AA461807, AA473595, AA638281, AA986879, AI480637, AI414420, AI430403, AU051497, AA671446, W87242,

AA823028, AV008133.1, AI035697, AV017984.1, AI415137, AA624777, AI552865.1, AI502808, AI105163, AI562292.1, N95975, AI548884, N95979, C96694, C98306, AA851073, AA925886, N96596, AI549483, AU029673, D15864, AI172584, AI500902, 107993, A04710.1, A00782.1, A08458.1, 195863, 136871, 168732, A56817.1, E13740, A29289.1, A60983.1, E12854, A52326.1, A49428.1, A11245.1, 113349, A20701.1, A13038.1, A10361.1, A49702.1, 119517, A22413.1, 186202, A49696.1, A49695.1, A25856.1, 112245, A18755.1, A14595.1, A02741.1, A08457.1, 140851

SEQ ID NO:90

AL031135, M63234, AF033097, AJ004935, U66300, Y15421, U52868, AF045432, Z97178, AF032922.1 , AF033096,

AF033565, AF039698.1, U65376, AF027174, U39066, U37573, S78798, U48696, AF030515, AJ010903, AF103726, Z49980, S83098, Y17148, AF061786, U44386, AC005868, X98048, U07163, Z29667, D10606, M84660, AC002392, AL049662.1, L34028, AF015463, AB011474, AF104414, L34027, U45981, Z73565, AJ001103, AE001409, S46763, M74445, Z68136, AF030694, AL034558.2, Z70720, AL021749, U67476, H53674, N55768, N84921, N86439, AA096061, N84859, N55711, AA093577, AA247828, AA093219, AA090302, N84575, AA249323, N55657, N84767, N84825, N55724, AA249356, AI594372.1, AA592233, AI647320.1, AA123399, AJ241143.1, AI353159, AI618635.1, AI353169, AF041408, AI617228.1, AI353694, AI354060, AI618568.1, AI617432.1, AA933363, AI616967.1, H36649, AI617214.1, T18143, AI616416.1, 117764, 117765, A43593.1, A43592.1, AR008277, 124903, AR008281, 123472, A18007.1, A38773.1, 138469, 143367, 124890, A38056.1, A71624.1, 144515, 144520, 125434, A63985.1, AR007269, AR016568, AR016569, 192757, 124891, 144509, 164576, AR007125 SEQ ID NO:91

AC002038, AC006548.19, AF130247, AC000056, AP000010.2, AL031665.18, AC005215, U82672, Z92545, AC002458, AC006461.2, AC007057.3, Z95118, AC004982, Z99774, AC004413, AAl 14131, H78605, H78687, R82153, AI282999, AA653319, N63471, AI340635, AA969018, AA923386, AA824410, AA551674, AI050003, AI301848, AI638856.1, AA853953, AI638318.1, AA432277, AA431270, R24442, AI681095.1, AI278431, All 90698, N50472, AA319938, N91422, T77772, AV003543.1, AA389188, AA919609, AA592159, AA899612, AA898213, AI083431, 146963, 109348, 196215, 109211, A51521.1, 108117, 143652, AR012060, 122507, 134294, A37262.1, E12183, E03829, 125849, 196182, AR020909, A52294.1, 159642, 176960, A58551.1, AR007159, A43445.1, AR007160, 138891, 173246, A51133.1, 151997, 173182, AR014241, AR003505, A51135.1, 101958, A67988.1, 140899 SEQ ID NO:92

AF150755.1, U67205, U67203, U67204, D13637, R78273, AI290663, AA297912, AA451993, AA302993, AI583168.1, H23080, AA178091, AA288614, AI504039, AA274809, W08027, W91036, AI413912, AA501231, AI429716, AI403713, AI238618, E03581, A16434.1, 170539, 187453 SEQ ID NO:93

U67205, U67203, AF150755.1, U67204, AC006299, L08471, AL031599, U27560, AC005670, AC000111, Z99112, U51998, AC006971.2, Z35640, AP000102.1, AB013389, AF071085, U30274, AC005137, L41269, U73396, X97233, AB010073, X94262, AF001881, AF103010, L76661, X97232, AF103011, AF103013, L76664, AF022044, Z21839, AA418046, AA393617, AA132249, W05478, W15464, T99842, AI383511.1, AI334080, AI225232, AI140733, AA552429, AI283044, AI269423, AI040542, AA813739, H90905, R14965, AI625631.1, AI383549, AA635490, AA256953, R50731, R27065, AI423682.1, AI248354, AA931236, AA737658, AA460634, R05339, AA829968, AA948123, AA777893, AA771745, AA769443, AA419127, AA361925, AA053786, H56090, R73015, R23185, AI631246.1, AI431288, AI097636, AA996225, AA878520, AA642284, AA621004, AA533878, R00269, AI422127.1, AI312823, AI025575, AA716080, AA613143, AA534584, AA419180, R48247, AI460341, AI460324, AI423007.1, AI375614, AI357646, AI263030, AI583151.1, AI421614.1, AI332316, AA960985, AA778125, AA776966, AA758265, AA648970, AA448346, AI587970.1, AV004416.1, AA666627, AA139382, AA087031, W89875, AI386222, AA175795, AA097956, AI180927, AI480941, AI115201, AI647028.1, AA462479, AA409953, AA153021, W59568, W75289, AA451536, AA020543, AI036133, AA796164, AA739299, AA003190, W98482, AA832781, AA241888, AA184762, AA145311, W64224, W53363, AA289197, AI595619.1, AI007134, AA253670, AA153027, W47956, C43219, Z29935, AI407349, T41447, AA686495, AA818516, AA946500, H35570, AI411156, T41484, AU052094.1, AI043927, AA894132, AI169190, AA801169,

AI045952, AA800545, AA801168, AI535064, AR012062, E07319, AR012121, 188853, A27001.1, 118360, AR014185, A27005.1, 109208, 185809, 173445, 113429, A19451.1, A65943.1, AR019266, A62673.1, 132320, 130447, A65401.1, A65962.1 SEQ ID NO:94

AF147338.1, AFl 11426, AC007048.3, AC005385, U60334, AF020802, Z83317, AJ229041, Z95889, AC000122, V00291, K02844, X00794, D16499, Z99753, AL031133, U95742, M10248, AC005249, Z81138, M16221, X52464, AI671570.1, T58078, T58198, AA918819, AA017211, AA247593, Tl 1529, AA807369, AA084789, AI341118, AA523267, T27488, AI194841, AV047074.2, AI462153, AV038768.1, AU041720, AV004917.1, AI463222, AV008122.1, AI255467, AI303531, AA646377, C78401, AA611173, AA960677, C78201, AA289775, AV030316.1, AI550786.1, AI505581, W91703, AA959869, AI607907.1, AI461822, AA538545, AA423250, AA259531, AA691770, AA423704, AI122141, W29889, AA734499, AA693177, AA762941, AA451530, AA839637, AI195362, AU030011, AU034860.1, AI009456, AI574942.1, H35669, AU006381, AI227633, AA955096, AI576027.1, AI138176, AA999125, AA924339, AA925033, AI179414, AI602918.1, AA395171, AA923867, AI577531.1, AI415951, AI031143, AI176215, AI236800, AI599936.1, AI410555, A69663.1, A69662.1 , E08631 , E03805

SEQ ID NO:95

AF147338.1, X80821, U60334, AC000122, AC005901, M96441, L28955, AL033377.2, AA918819, T58078, T58198, AA496039, R68550, R86033, AA652658, AI291783, AI291446, H93102, AI376609.1, AI567672.1, AI351633, R77622,

AA548171, H44377, T11529, AA839637, AI182684, AI122141, AA762941, AA423704, AA451530, W29889, AA69I770, W84193, AI098323, W10598, AA215027, AA764637, AI606411.1, AI006866, AA638627, AA919762, AA839981, AI046809, AI121151, AA170888, AA145588, AI315950, AI465123, AI225473, AA433507, AA570928, C72277, AU030011, AI096187, E08631, A45355.1, 107373, AR018795, 138435, 108188, 123879

SEQ ID NO. 96

NGO-Br-37 combined

NM_006644.1, AB003333.1, AF039695.1, AB003334.1, D86956.1, NM H3559.1, D67017.1, D67016.1, L40406.1,

Z47807.1, AB005275.1, AB005282.1, AB005281.1, AB005278.1, AB005276.1, AB005274.1, NM_011020.1, U23921.1, D49482.1, AB001926.1, NM_014278.1, AB023421.1, L12723.1, AB005279.1, X67643.1, AB005280.1, AF077354.1, NM_008300.1, AB023420.1, D85904.1, ACOl 1661.5, AL109620.4, L08605.1, AC005851.2, AC011294.3, AI658961.1, AW571648.I, AW474070.1, AW572452.1, AW470142.1, AW608075.1, AW385582.1, AW577563.1, AW820299.1, AA232636.1, AI758907.1, AW859988.1, AW859943.1, AW630933.1, AW820234.1, AW604836.1, AW390368.1, AW316651.1, AW771160.1, AA166806.1, AW820232.1, H63595.1, AI002886.1, AL042714.2, AI751852.1, AW631423.1, H912U.1, H54656.1, AA334479.1, AI651186.1, AA777031.1, AW628153.1, AI223825.1, AA136424.1, AA953645.1, AI582484.1, AA394027.1, AA714219.1, AA805016.1, AW103624.1, AA580845.1, F07487.1, AI288972.1, AI337175.1, F08794.1, AI656127.1, AI633338.1, AI203278.1, AI094015.1, AI800379.1, H64073.1, AW389335.1, Z20100.1, AA094644.1, T63090.1, AI799265.1, AA435594.1, AA580712.1, AA105012.1, AI267631.1_> AA777564.1_> N84915.1, AA485036.1, AA311379.1, AW206874.1, W86141.1, AA571359.1, AA885873.1, N84914.1, AI290252.1, AA624532.1, Z21219.1. AA811573.1, AW609781.1, AI838486.1, AW020035.1, AW210124.1, AI702970.1, T34627.1. Z21220.1, C81194.1, H63551.1, X85639.1₎ AW238563.1, H64019.1, AW085874.1, AA278231.1_> AA580595.1, H91160.1, AA572403.1, H54657.1, AA571473.1, AA843693.1, AW391561.1, Z41841.1, AA417317.1, W45471.1, AW362751.1, AA867489.1, AA749004.1, AL137142.8, AC015501.3, AC021286.3, AC020834.2, AC044841.2, AC023471.2, AC016715.2, AC018818.3, AL138763.2, AC021531.3, AC005506.6, AC018789.2, AC014468.1, AL162502.2, AL034557.7

SEQ ID NO. 97 NGO-Br-37 M 136/T73' NM_006644.1, AF039695.1_> AB003334.1, AB003333.1, D86956.1, Z47807.1, D67017.1, D67016.1, NM_013559.1_>

L40406.1, AB005282.1, AB005281.1, AC005371.1, AL163279.2, AE003720.1, AE003562.1, AC006548.20, AC006160.9, AF016672.2, AC005951.1, AC004251.1, ALl 63234.2, Z92838.1, Z83109.1, Z79753.1, Z71259.1, Z83827.1, AL035258.10, AP001689.1, AP000477.2, AW571648.1, AW572452.1, AW474070.1, AI658961.1, AW470142.1, AW385582.1, AW316651.1, AW608075.1, AA232636.1, AW771160.1, AA166806.1, AA136424.1, AI651186.1, AI223825.1, AI751852.1, AA394027.1, AA435594.1, AI337175.1, AI582484.1, AW628153.1, AW103624.1, AA953645.1, AA485036.1, AI288972.1, AW820299.1, AW390368.1, AI799265.1, Z20100.1, AW085874.1, AW604836.1, AA417317.1, AW609781.1, AW020035.1, AI838486.1, C81194.1, AA624532.1, AA571359.1, AA079853.1, T34627.1, Z21220.1, AA843693.1, AA571473.1, AA572403.1, F07487.1, AA278231.1, F08794.1, T63090.1, AW859988.1, AW859943.1, AW820234.1, AW491178.1, AI842560.1, AV275994.1, AA967441.1, AA856248.1, Z41841.1, AW820232.1, AW389335.1, AA777031.1, AA238818.1, AV347805.1, AI970469.1, AV178670.1, AV141053.1, AI365340.1,

AI341168.1, All 15351.1, C56104.1, C55163.1, C54236.1, C54007.1, D64277.1, T26732.1, D33807.1, AL137142.8, AC008689.4, AC010785.3, AC016715.2, ACOl 1743.3, AF129408.1, AC025243.3, AC027399.2, AC026927.2, AC012569.3, AC005506.6, AC009039.5, AC007337.2, AC008361.7, AC021326.1, AC014468.1, AF176680.1, AP001895.1, AP001563.1, AC055800.2, AC027502.3, AC044830.2, AC034128.2, AC008155.6, AC016926.4, AC027359.2, AC027002.2, AC027057.2, AC026650.3, AC020991.3, AC009925.3, AC018954.4, AC024681.2, AC016306.3, AC016997.4, AC019032.3, AC021188.2, AC013110.1, AL109916.3, AL162264.4, AL161653.7, AL138705.3, AL161738.4, AL158817.2, AL138694.5, AL137247.3, AP001803.1, Z98863.1,

SEQ ID NO. 98 NGO-Br-37 MK151/T73'

NM_006644.1, AF039695.1, AB003334.1, AB003333.1, D86956.1, D67017.1, D67016.1, NM_013559.1, L40406.1, Z47807.1, AB005282.1, AB005281.1, AB023420.1, X67643.1, AE003589.1, AC005762.1, AC000119.1, AE003522.1, AE003473.1, AC009223.2, AF030511.1, AF067211.2, AC005951.1, U22892.1, U84144.1, AC002312.1, AX002407.1, X04465.1, AL034582.11, U77302.1, AL078599.19, AL009183.10₎ Z74617.1, AL035258.10, X16094.1, M36578.1₎ L08612.1, X01647.1₎ AB018706.1, G21718.1₎ G38495.1, G58719.1, AL144420.1, G03936.1, G27119.1, G22600.1, AL149482.1, AL148977.1, AL145762.1, Z94707.1, AL022449.1, G28140.1, G27716.1, G25125.1, G24942.1 , L30947.1 , G60761.1, G50693.1, G48927.1_> G62261.1, G41307.1, AF052368.1, G28922.1, G19992.1, G16172.1, G12990.1, G36232.1, G35802.1, AL158374.1, AL153532.1, AL153227.1, AL151189.1, AL150403.1, AL148989.1, AL147211.1, AL143371.1, G06747.1, G06621.1, G05724.1, AJ229990.1, Z54069.1, Z67861.1, Z66769.1, Z32058.1, AL137142.8, AC012569.3, AP001895.1, AP001563.1, AC027117.2, AC022671.2, AC015904.3, AC025383.2, AC022797.3, AC020725.3, AC021722.4, AC009039.5, AC007337.2, AC023309.1, ACOl 7242.1, AL353894.3, AL162502.2, AC032034.2, AC008902.3, AC008689.4, AC034128.2, AC027057.2, AC025220.2, AC010912.3, AC017150.1, AL137247.3, AL031745.7,

SEQ ID NO. 99 NGO-Br-37 MK212/T3 5' NM_006644.1, AB003333.1, AF039695.1, AB003334.1, D86956.1, NM_013559.1, D67017.1, D67016.1, L40406.1,

Z47807.1, AB005275.1, AB005276.1, AB005278.1, AB005274.1, AF077354.1, NM_00830O.l, D85904.1, NM_011020.1, U23921.1, D49482.1, AB001926.1, AB023420.1, X67643.1, L12723.1, AC005851.2, AC010852.5, AC003099.1, AP001821.1, AC024813.1, AC004668.1, NM_005742.1, AC004879.1, AC005870.2, AC006518.17, U73002.1, AF004739.1, U41009.1, D49489.1, AJ002201.1, AB023039.1, L16771.1, X67814.1, AW577563.1, AW630933.1, AI758907.1, H63595.1, AI002886.1, AL042714.2, AW631423.1, H91211.1, H54656.1, AA334479.1, AA714219.1,

AA805016.1, AA580845.1, AI656127.1, AI633338.1, AI203278.1, AI094015.1, AI800379.1, H64073.1, AA094644.1, AA580712.1, AA105012.1, AI267631.1, AA777564.1, N84915.1, AA311379.1, AW206874.1, W86141.1, AA885873.1, N84914.1, AI290252.1, Z21219.1, AA811573.1, AW210124.1, AI702970.1, X85639.1, AW238563.1, H63551.1, H64019.1, AA580595.1, H91160.1, H54657.1, W45471.1, AA867489.1, AA777031.1, AA749004.1, W86085.1, AA108277.1, AA555929.1, AA555921.1, AW820231.1, AW820224.1, AW391572.1, AW362766.1, AW820299.1, AW859988.1, AW859943.1, AW820234.1, AW820232.1, AW604836.1, AW391561.1, AW362751.1, AW229772.1, AI956648.1, AA870633.1, AA821679.1, AA543642.1, AA518224.1, AA437859.1, AA125191.1, AA103602.1, AW582504.1, AW609867.1, AW817504.1, AW817496.1, AW817440.1, AW817432.1, AW817364.1, AW817315.1, AW817234.1, AW817219.1, AW817153.1, AW609859.1, AW609842.1, AW609816.1, AW609809.1, AW609784.1, AW582499.1, AW391901.1, AW391888.1, AW381775.1₎ AW372095.1, AW371570.1, AW371556.1, AW371552.1, AW371548.1, AW371546.1, ALl 35032.1, AI907727.1, AA191559.1, AL137142.8, AC024112.9, AC027009.2, AC009290.2, AC021255.2, AC020834.2, AC044841.2, AC068895.1, AL354918.3, AL138763.2, AL049812.13, AP000886.1, AC058786.7, AC027238.2, AC013545.2, AL159973.2, AP001863.1, SEQ ID NO. 100 NGO-Br-37 MK212 T73'

NMJJ06644.1, AF039695.1, AB003334.1, AB003333.1, D86956.1, D67017.1, D67016.1, NM_013559.1, L40406.1, Z47807.1, AB005282.1, AB005281.1, AC005215.1, AL163279.2, AF193508.1, AC006080.1, AC009223.2, AF016672.2, U22892.1, AL161539.2, Z98981.2, X04465.1, Z92838.1, Z83109.1, AL035258.10, AB042297.1, Z97336.1, L08612.1, X01647.1, AI658961.1, AW571648.1, AW474070.1, AW572452.1, AW608075.1, AW385582.1, AW470142.1, A W316651.1 , AA232636.1 , AAl 66806.1 , AI751852.1 , AW771160.1 , AW628153.1, AW820299.1 , AA953645.1 , AI337175.1, AI651186.1, AA394027.1, AW390368.1, AA136424.1, AI223825.1, AW604836.1, AA435594.1, AI582484.1, AW103624.1, AA485036.1, AI288972.1, AA624532.1, AA571359.1, F07487.1, AW859988.1, AW859943.1, Z20100.1, F08794.1, AW820234.1, AW085874.1, AI799265.1, T63090.1, AA572403.1, AW609781.1, AI838486.1, AA571473.1, AW820232.1, C81194.1, AA417317.1, AW020035.1, AW389335.1, AA079853.1, T34627.1, AA777031.1, Z21220.1, AW491178.1, AI842560.1, AA843693.1, AV275994.1, AA278231.1, AA967441.1, AA856248.1, Z41841.1, AA238818.1, All 15351.1, AV347805.1, AW147250.1, AV348434.1, AV200611.1, AV181186.1, AV178670.1, AV059415.1, AU055867.1, AI365340.1, AI341168.1, AA882330.1, C78586.1, C56104.1, C55163.1, C54236.1, C54007.1, C34122.1, C31088.1, AA522360.1, C12303.1, D64277.1, R98128.1, T26732.1, D33807.1, AL137142.8, AC012569.3, AP001895.1, AP001563.1, AC027128.3, AC023471.2, AF129408.1, AC021710.4, AC020725.3, AC009039.5, AC007337.2, AC008361.7, AC014468.1, AC026863.3, AC032034.2, AC008902.3, AC027359.2, AC026650.3, AC019267.3, AC024681.2, AC022776.2, AC018519.3, AL109916.3, AL162264.4, AL138705.3, AL158817.2, SEQ ID NO. 101 NGO-Br-37 M 379/T73'

NM_006644.1, AF039695.1, AB003334.1, AB003333.1, D86956.1, D67017.1, D67016.1, NM_013559.1, L40406.1, Z47807.1, AB005281.1, AB005282.1, AC005371.1, AB005280.1, AC009223.2, AC005951.1, Z79754.1, AL009183.10, Z74617.1, AL035258.10, AW571648.1, AI658961.1, AW572452.1, AW474070.1, AW385582.1, AW608075.1, AW470142.1, AW316651.1, AA232636.1, AA166806.1, AI751852.1, AW771160.1, AW628153.1, AA394027.1, AA953645.1, AI651186.1, AA136424.1, AW103624.1, AW820299.1, AI223825.1, AI582484.1, AI337175.1, AW390368.1, AA435594.1, AA485036.1, AI288972.1, AW604836.1, Z20100.1, AI799265.1, AW609781.1, F08794.1, F07487.1, AW859988.1, AW859943.1, AW085874.1, T63090.1, AW820234.1, AA624532.1, AA571359.1, AA417317.1, AA572403.1, AW020035.1 , AI838486.1, AA571473.1, T34627.1, Z21220.1 , C81 194.1, AW820232.1, AA079853.1, AA278231.1, AA843693.1 , AW491178.1 , AI842560.1 , AA967441.1 , AA856248.1 , AV275994.1 , Z41841.1 , AW389335.1 , AA238818.1, AA524050.1 , AW670042.1, AW467587.1, AW440906.1, AW301952.1, AV347805.1 , AW148805.1, AW080765.1, AW073417.1 , A W021546.1, AW006027.1, AI870113.1, AI766462.1, AI699756.1, AI680535.1 , AI563975.1, AI510837.1 , AI378898.1 , AI378423.1 , AI290741.1 , AI288939.1 , AI09221 1.1, AA987850.1 , AA877634.1 , AA806917.1 , AA745943.1, AA725830.1 , AA682373.1, AA506124.1, AA465237.1 , AA232282.1, AA129977.1, AA035579.1, W58443.1, N91 182.1, T63600.1, AL137142.8, AC012569.3, AP001895.1 , AP001563.1, AC008689.4, AC0271 17.2, AC022671.2, AC021710.4, AC020725.3, AC009039.5, AC007337.2, AC023309.1, AF176680.1, AL132989.1, AC034128.2, AC027057.2, AC025225.2, AC024681.2, AC023557.1, AL356059.1, ALl 39800.1, AP000780.1,

SEQ ID NO. 102

NGO-Br-37

M 394/T73'

NM_006644.1, AF039695.1, AB003334.1, AB003333.1, D86956.1, D67017.1, D67016.1, NM_013559.1, L40406.1, Z47807.1, AB005281.1, AB005282.1, AB023420.1, X67643.1, NM_008300.1, AC005371.1, D85904.1, AC005215.1, ACOl 1294.3, AE003589.1, AF241729.1, AC005762.1, AC007161.1, AC005539.1, AC005951.1, Z71259.1 , Z99289.1 , AL035258.10, Z74739.1, AI658961.1 , AW571648.1, AW474070.1, AW608075.1, AW572452.1, AW385582.1 , AW470142.1, AI751852.1, AW316651.1, AA166806.1, AW628153.1, AA232636.1, AA953645.1, AW820299.1, AW390368.1, AW604836.1, AW771 160.1, AA394027.1, AW103624.1, AI651 186.1, AA136424.1, AI223825.1, AI337175.1 , AW820234.1, F07487.1, AA485036.1, AW859988.1, AW859943.1, F08794.1, AI582484.1, AA435594.1, T63090.1, AI288972.1, AW820232.1, AW609781.1, AI799265.1 , Z20100.1 , AA624532.1, AA571359.1, AW085874.1, AW389335.1, AI838486.1, AA572403.1, C81194.1, AA571473.1, AA417317.1, AW020035.1, AA777031.1, T34627.1, AA079853.1, Z21220.1, AA278231.1, AA843693.1, AW491178.1, AI842560.1, Z41841.1, AV275994.1, AA967441.1, AA856248.1, AW861588.1, AW819997.1, AW819755.1, AW604699.1, AW366794.1, AW085727.1, AI925201.1, AI754819.1, AI567970.1, AA703912.1, AA493400.1, AA173193.1, R54223.1, AW754207.1, AW545353.1, AW545094.1, AW542227.1, AW537735.1, AW060626.1, AI956869.1, AA823019.1, AA799083.1, AA445826.1, AA238818.1, AA205597.1 , AW604696.1, AW583074.1 , AW578928.1, AI626242.1 , AA542420.1 , AV347805.1, AW619786.1 , AW391561.1, AI806597.1, AV059415.1, All 15351.1, R98128.1 , AL137142.8, AC008689.4, AC027399.2, AC026927.2, AC022212.3, AC023574.2, AC012569.3, AC020725.3, AC009039.5, AC007337.2, AC017242.1, AF176680.1, AL353894.3, AL353753.1, AL158817.2, AP001895.1, AP001563.1, AC034128.2, AC016926.4, AC024909.8, AC012135.2, AC017024.4, AC025673.2, AC027057.2, AC022537.3, AC025971.2, AC009925.3, AC024681.2, AC021571.3, AC021903.5, AC012434.3, AC009969.4, AC021326.1, AC013759.2, AC013493.1, AL121927.18, AL354749.2, AL136220.2, AL133350.7, AL139800.1 , AL031745.7, SEQ ID NO 103 NGO-Br-37 MK401/T3 5'

NM_006644.1, AF039695.1 , AB003334.1, AB003333.1, D86956.1, Z47807.1, D67017.1, D67016.1, NM_013559.1, L40406.1, NM_011020.1, U23921.1, D49482.1 , AB001926.1 , NM_014278.1, AB023421.1, L12723.1, AB005279.1, AB005280.1, X67643.1 , AF077354.1, NM_008300.1 , AB023420.1 , D85904.1 , AB005281.1, AL109620.4, L08605.1, AE003589.1, AF161311.1, AF136711.1, AE001434.1, AE001433.1, AC005762.1, AC004045.1, AC006403.3, AE003657.1, AE003645.1, AE003411.1, ACOl 1609.9, ACOl 1662.1, AC006288.1, X94582.1 , X94581.1, AB020374.1, AB020372.1, AB020370.1, AB020368.1 , AB020366.1, AB020364.1, AB020362.1, AB020360.1, AB020356.1, AB020350.1, AB020347.1, AB020345.1, AB020343.1, AC010722.2, ACOl 1299.3, AF169288.1, AC005161.1, AF198095.1, AF128525.1, Z95559.1 , ALl 09865.36, AL034488.1 , ALl 10490.1 , ALl 17205.2, Z35595.1, AB020876.1, AW820299.1, AW390368.1, AW859988.1, AW859943.1, AW820234.1, AW604836.1 , AW608075.1 , AI658961.1, AW820232.1, AW628153.1, AI751852.1, AW385582.1, F07487.1, AA777031.1, F08794.1 , AA953645.1, AW389335.1 , T63090.1 , AA166806.1 , AW474070.1, AW571648.1, AA394027.1 , AW103624.1, AW609781.1 , AA485036.1, AW572452.1, AW391561.1 , AI838486.1, AA571359.1, AW316651.1, AW362751.1, C81194.1, AW470142.1, AJ397361.1, AA624532.1, AW754210.1, AW583074.1, AI760838.1, AI337175.1, AW819755.1, AW578928.1, AA212025.I , AU080443.1, AW206874.1, AW125594.1, AA919208.1, AA755774.1, AA645750.1, AA615363.1 , AA445826.1, AAl 17945.1, AW819997.1, AI626242.1, AI094015.1, W86085.1, AA885873.1, AA626524.1, W22433.1, H63551.1, T29047.1 , AW861588.1 , AW604699.1 , AW366794.1 , AW085727.1 , AI925201.1 , AI754819.1, AI567970.1 , AU035998.1, AA703912.1, AA493400.1, AA431598.1, AA173193.1, H64019.1, R54223.1, AI758907.1, AW754207.1, AW545353.1 , AW545094.1, AW542227.1 , AW537735.1, AW060626.1, AI956869.1 , AI702970.1, AA823019.1, AA799083.1, AA777564.1, AW839103.1, AA555929.1, AA370218.1, AA205597.1, AW604696.1, AA580595.1, AA542420.1, AW861596.1, AI314009.1, C76500.1, AA549968.1, H91160.1, AL137142.8, AC015501.3, AC021286.3, AC008642.3, AC006278.6, AC019327.4, AC017242.1, AL034557.7, AC025358.3, ACOl 1333.4, AC027429.2, AC025673.2, AC027054.2, AC024968.2, AC016459.2, AC021997.2, AC017097.2, AL139034.3, AL157821.1,

SEQ ID NO. 104

NGO-Br-37

MK401 T7 3'

NM_006644.1, AF039695.1, AB003334.1, AB003333.1, D86956.1, D67017.1, D67016.1, NM_013559.1, L40406.1, Z47807.1 , AB005282.1 , AB005281.1 , D32136.1 , AE003798.1 , AE003579.1 , AF067211.2, AC005926.1 , AC005951.1, U22892.1, AC004429.1 , AC002312.1, AL161539.2, X04465.1, AL078599.19, AL009183.10, Z74617.1 , AL035258.10, Z97336.1, XI 6094.1, M36578.1, L08612.1, X01647.1, AW571648.1, AI658961.I, AW572452.1, AW474070.1, AW385582.1, AW470142.1, AW608075.1 , AW316651.1₎ AA232636.1_> AW771160.1 , AI651186.1, AA166806.1 , AA136424.1, AI223825.1 , AA435594.1, AI582484.1, AI751852.1, AA394027.1, AI288972.1, AW628153.1 , AI337175.1, AA953645.1, AWI03624.1, AI799265.1, Z20100.1, AW820299.1, AW390368.1, AW085874.1, AA485036.1, AW604836.1, AA624532.1, AA571359.1, AA572403.1, AA417317.1, F07487.1, AA571473.1, F08794.1, AW609781.1, AW020035.1, AW859988.1 , AW859943.1 , AW820234.1, T63090.1, T34627.1, AI838486.1, Z21220.1, C81 194.1, AA843693.1, AA278231.1, AA079853.1, AW491178.1, AI842560.1, AV275994.1, AW820232.1, AA967441.1, AA856248.1, Z41841.1 , AA238818.1 , All 15351.1, AV347805.1, AW147250.1, AI937768.1, AV200611.1, AV181186.1, AU055867.1 , C34122.1, C31088.1, C12303.1, AL137142.8, AC012569.3, AP001895.1, AP001563.1, AC0271 17.2, AC022671.2, AC022071.7, AC021710.4, AC022797.3, AC020725.3, AC021722.4, AC009039.5, AC007337.2, AC023309.1, AC018789.2, AC063937.2, AC027648.6, AC008158.3, AC026340.2, AC034128.2, AC027730.2, AC055761.2, AC027057.2, AC022530.4, AC025220.2, AC025973.2, AC025231.2, AC015808.3, AC025225.2, AC009925.3, AC024681.2, AC022461.3, AC023557.1, AC009969.4, AC015976.3, AC020050.1, AC018258.1, AC013493.1 , AC007420.3, AC004581.1, AL355294.2, AL356059.1 , AL158817.2, AL121750.3, AP001803.1, AL031745.7. AP000780.1,

SEQ ID NO. 105 NGO-Br-37 MK508/T3 5'

NM_006644.1, AF039695.1, AB003334.1, ABO03333.1, D86956.1, D67017.1, D67016.1, NM_013559.1, L40406.1, Z47807.1 , AB005282.1 , AB005281.1 , AB005280.1 , AB023420.1 , X67643.1 , NM_008300.1 , D85904.1 , AF262041.1 , ACOl 1661.5, AL163279.2, AL109620.4, AC004684.2, AE003720.1, AE003522.1, AF222716.1, AC009223.2, AC004251.1, AC002367.1, AL163234.2, AL161553.2, AL161539.2, X04465.1, AL139077.2, AL009183.10, AP001689.1, Z97336.1, AI658961.1, AW571648.1, AW474070.1, AW572452.1, AW470142.1, AW608075.1, AW385582.1, AA232636.1, AW316651.1, AW771160.1, AAl 66806.1, AI751852.1 , AI651 186.1, AI223825.1. AW628153.1, AA136424.1, AA953645.1 , AI582484.1, AA394027.1, AW820299.1 , AW390368.1, AW103624.1 , AI288972.1, AI337175.1, AW604836.1, Z20100.1, AI799265.1, AA435594.1, AA485036.1, AA571359.1, F07487.1, F08794.1, T63090.1, AA624532.1 , AW859988.1, AW859943.1, AW609781.1 , AI838486.1 , AW020035.1 , AW820234.1, T34627.1, Z21220.1, C81 194.1, AW085874.1, AA278231.1, AA572403.1, AW820232.1, AA571473.1, AA843693.1, Z41841.1, AA417317.1, AW389335.1, AA079853.1, AW491178.1, AI842560.1, AV275994.1, AW837156.1, AA967441.1, AA856248.1, AA777031.1, AW068948.1, F03714.1, AA238818.1, AV146133.1, AI528497.1, All 15351.1, AA462732.1, AW861588.1, AW819997.1, AW819755.1, AW604699.1, AW366794.1, AW085727.1, AI925201.1, AV149067.1, AI754819.1, AI567970.1, AA703912.1, AA493400.1, AA173193.1, R54223.1, AW545353.1, AW545094.1, AW542227.1 , AW537735.1, AW060626.1, AI956869.1, AA823019.1, AA799083.1, AA445826.1, AV160311.1, AI600071.1, AI236601.1 , AA205597.1 , AW604696.1, AW700938.1 , AI790491.1 , AA681295.1 , AU053616.1, AL137142.8, AC012569.3, AP001895.1, AP001563.1, AC023471.2, AC021531.3, AC005506.6, AC021722.4, AC009039.5, AC007337.2, AC008361.7, AC014468.1 , AL162502.2, AC027149.2, AC009634.3, AC019267.3, AC024681.2, AC006281.6, AC022461.3, AL109916.3, AL138705.3, AL161449.2, Z98863.1,

SEQ ID NO. 106 NGO-Br-37 MK612 T3 5' NM_006644.1 , AF039695.1, AB003334.1, AB003333.1, D86956.1, Z47807.1, D67017.1, D67016.1, NM_013559.1, L40406.1, AB005281.1, NM_011020.1, U23921.1, D49482.1, ABOO 1926.1 , NM_014278.1, AB023421.1, L12723.1, AB005279.1, X67643.1 , AF077354.1, NM_008300.1, AB023420.1, D85904.1, AB005280.1, L08605.1, AE003589.1, AF161311.1, AF136711.1, AE001434.1, AE001433.1, AC005762.1, AC004045.1, AC006403.3, ACOl 1609.9, AF049895.1, AC006288.1, AC005951.1, AE001393.1, AF068862.1, L04162.1 , AB026651.1, L08135.1 , L22219.1, AW820299.1 , AW608075.1, AW604836.1, AW390368.1, AI658961.1, AW628153.1, AW859988.1, AW859943.1, AI751852.1, AW820234.1, AW385582.1, AW820232.1, AA953645.1, AA166806.1, AW571648.1, AA394027.1, AW474070.1, AA777031.1, AW103624.1, F07487.1, AW572452.1, F08794.1, AW389335.1, AA485036.1, T63090.1, AW316651.1, AW609781.1, AW470142.1, AW391561.1₎ AI838486.1, AI337175.1, AA571359.1, AW362751.1, C81194.1 , AA624532.1, AA079853.1, AA232636.1, AA572403.1, AJ397361.1 , AA571473.1, AW771160.1 , AW754210.1, AW583074.1, AW206874.1, AI760838.1, AW578928.1, AA212025.1, AI094015.1, AA645750.1, W86085.1,

AW819755.1, AA885873.1, AW125594.1, AU080443.1, AA919208.1, AA755774.1, AA615363.1, AA445826.1, AA117945.1 , H63551.1, H64019.1, AI758907.1, AI702970.1, AA777564.1, AW819997.1, AA626524.1, AA580595.1, W22433.1, H91160.1, T29047.1 , AW861588.1 , AW839103.1, AW604699.1, AW366794.1, AW085727.1, AI925201.1, AI754819.1, AI626242.1, AI567970.1 , AU035998.1 , AA703912.1, AA493400.1, AA370218.1, AA173193.1, H54657.1 , R54223.1, AW754207.1, AW545353.1, AW545094.1, AW542227.1, AW537735.1, AW060626.1, AI956869.1, AI314009.1, AA823019.1, AA799083.1, AA555929.1, AA205597.1, AW604696.1, AA542420.1, AL137142.8, AC015501.3, AC021286.3, AC008642.3, AC023574.2, AC006279.6, AC006278.6, AC019327.4, AC009039.5, AC007337.2, AC017242.1, AL353894.3, AL353753.1, AL034557.7, AC055800.2, AC037481.2, AC024891.8, AC026825.2, AC025358.3, ACOl 1333.4, AC008714.2, AC034128.2, AC024909.8, AC015533.4, AC027429.2, AC016805.3, AC009786.2, AC027057.2, AC027054.2, AC025538.3, AC024968.2, AC024681.2, AC016459.2, AC020712.4, AC021903.5, AC022758.3, AC021997.2, AC017097.2, AC022725.1, AC009728.2, AL353714.2, AL138705.3, AL355483.1, AL355135.1, AL353630.1, AC002421.1, AL157821.1, AL138920.2, AL137247.3, SEQ ID NO. 107 NGO-Br-37 MK661/T3 5'

NM_006644.1, AF039695.1, AB003334.1, AB003333.1, D86956.1, NM_013559.1, D67017.1, D67016.1, L40406.1, Z47807.1, AB005282.1, AB005281.1, AL163279.2, AF193508.1, AE003720.1, AC009223.2, AC004251.1, AL163234.2, AL161553.2, AL161539.2, AL139077.2, AP001689.1, Z97336.1, AP000477.2, AE003728.1, AE003686.1, AE003627.1, AE003520.1, AF065404.1, AC000104.1, AC005771.1, AF069291.1, U67495.1, AL163285.2, Z68004.1, AW571648.1, AW572452.1, AW474070.1, AW470142.1, AA232636.1, AI658961.1, AW771160.1, AW316651.1, AW608075.1, AW385582.1, AI651186.1, AA136424.1, AI223825.1, AA435594.1, AI582484.1, AI337175.1, AI288972.1, AA166806.1, Z20100.1, AI799265.1, AW085874.1, AA624532.1, AA571473.1, AA571359.1, AA572403.1, AA417317.1, AI751852.1, AA394027.1, AW020035.1, AI838486.1, C81194.1, T34627.1. Z21220.1, AW628153.1, AW103624.1, AW491178.1, AI842560.1, AA843693.1, AV275994.1, AW604836.1, AA278231.1, AW820299.1, AA485036.1, AA953645.1, AA967441.1, AA856248.1, AA079853.1, Z41841.1, AA238818.1, AW390368.1, All 15351.1, AV347805.1, AW147250.1, AV348434.1, AV200611.1, AV181186.1, AV178670.1, AU055867.1, AI365340.1, AI341168.1, AA882330.1, AA834218.1, C56104.1, C55163.1, C54236.1, C54007.1, C34122.1, C31088.1, C12303.1, D64277.1, T26732.1, D33807.1, AW383218.1, AV272251.1, AV269906.1, AW037622.1, AI807000.1, AI804139.1, AA893644.1, AL137142.8, AC012569.3, AP001895.1, AP001563.1, AC027117.2, AC022671.2, AC027128.3, AC023471.2, AC018818.3, AF129408.1, AC021531.3, AC005506.6, AC021722.4, AC008361.7, AC018789.2, AC014468.1, AC044830.2, AC008902.3, AC027359.2, AC009634.3, AC022530.4, AC026650.3, AC025973.2, ACOl 9267.3, AC009925.3, AC018717.5, AC015974.4, AC013110.1, Z98863.1,

SEQ ID NO. 108

NGO-Br-38

M 015/T3 5'

D86956.1, AB003334.1, NM_006644.1, AB003333.1, AF039695.1, D67017.1, D67016.1, NM_013559.1, L40406.1, Z47807.1, AB005267.1 , AB005269.1 , AB005268.1, AB023420.1, L12723.1, X67643.1, ACOl 1013.17, NM_008300.1,

AF077354.1, D85904.1, NM_014278.1, NM_011020.1, U23921.1, AB023421.1. D49482.1, AL034403.18, NC_001145.1, NM_004455.1, AC007240.2, U67I91.1, AL121580.8, AL035448.28, Z49260.1 , X67640.1 , AC020629.6, AC007018.6, AC004681.2, AE003808.1, AE003644.1, AE003458.1, AE003410.1, AC004740.1, NM_012980.1, AC004016.1, AC007967.3, AC007447.6, AF132160.1, AC007073.2, AE001517.1, AC005938.1, U46034.1, AC004320.1, AF038606.1, AL034423.18, AL109733.1, AL049548.6, Z98046.1, AW137489.I, AL120219.1, AW665093.1, AI052062.1, AI023309.1, AU077146.1, AL043449.1, AA219339.1, AI052577.1, AA078767.1, AI003212.1, AA081692.1, AW475538.1, AI787816.1, AI746652.1, AA360776.1, AI006526.1, AW209689.1, AW105834.1, AL045611.2, AI931227.1, AW227137.1, AL044212.1, AU066691.1, AA168224.1, AW069322.1, AW318627.1, AI956324.1, AI956249.1, AI316935.1, AA408320.1, AW227160.1, AA407914.1, AA226851.1, AW557363.1, AW416815.1, AW141567.1, AI677492.1, AI087282.1, AA840049.1, AA726333.1, AW223053.1, AV294240.1, AI986092.1, AI904139.1, AV052268.1, AI510184.1, AI108231.1, AA799078.1, AA038974.1, N94129.1, AL137142.8, AL138965.3, AC046137.3, AC020834.2, AC015501.3, AC021286.3, AC019130.3, AL161914.6, AC026223.2, AC023996.2, AL355495.1, AC068988.2, AC053523.2, AC016937.3, AC016496.3, AC019266.3, AC026641.1, AC024429.2, AC019108.4, AC009969.4, AC023395.2, AC060786.2, AC023513.8, AC023599.7, AC068719.1, AC023175.1, AC024943.5, AC027239.2, AC023257.2, AC027676.2, AC027070.2, AC011230.2, AC044785.1, AC024673.2, AC009560.3, AC015810.3, AC019276.3, AC021701.3, AC025813.1, AC024370.2, AC008350.3, AC021304.2, AC009972.4, AC012344.3, AC018305.1, AC008232.3, AC014298.1, AC015847.1, AC013236.1, AL109835.12, AL139110.1, AP001998.1, AP001782.1,

SEQ ID NO. 109 NGO-Br-38 MK015/T73'

AF039695.1, D86956.1, NM_006644.1, AB003334.1, AB003333.1, D67017.1, D67016.1, AB005282.1, NM_013559.1, L40406.1, Z47807.1, AE003611.1, AL035259.1, AC007677.3, AE003628.1, AE003571.1, AE003567.1, AC007066.4, AL022164.1, AF218257.1, AC016752.2, AC006413.3, AE003477.1, AC005927.2, AC007061.5, U71249.1, AC003078.1, U95740.1, AF104919.1, AC005324.1, AL133419.15, AL034556.3, AL138995.3, AL161492.2, AL035706.10, AL049188.3, AJ010316.1, AB004275.1, AB006696.1, AP000555.1, Z11695.1, AB006689.1, AA843693.1, AA543054.1, AI742981.1, AW612980.1, AW612983.1, AI582881.1, AI751853.1, AI378269.1, AI920808.1, AI654608.1, AI819251.1, AI337175.1, AI753470.1, AI831339.1, AI312753.1, AI803588.1, AI563996.1, AW015796.1, AW117974.1, AI668853.1, AA993280.1, AA912023.1, AA535277.1, AI123280.1, AA632202.1, AW027050.1, AW627645.1, AA761750.1, AI223412.1, AA219263.1, AW068948.1, AA166716.1, AA482770.1, AW236067.1, AA485151.1, AI369932.1, AI250881.I,

AA933881.1, AI262020.1, AI050716.1, H52653.1, AA678506.1, AA582157.1, AW340810.1, AI493255.1, AW837156.1, AI673134.1, T58153.1, T36072.1, F22410.1, AA417317.1, AW020035.1, AI361237.1, AA278231.1, AA810686.1_> AA730742.1, AA082043.1, D58216.1, D29622.1, AA233888.1, AI630481.1, AI612928.1, D29371.1, AA731716.1, AA417255.1, AA804371.1, AA465183.1, AA780104.1, AA491870.1, T34783.1, Z41841.1, AW771160.1, AI357434.1, AI799265.1, AI582484.1₎ AI288972.1 , F03714.1₎ AW381433.1, AW381418.1₎ T10428.1_> AW163535.1_> AW059721.1_> AA773435.1, AI651 186.1, AW824279.1, AW544862.1, AW061135.1, ALl 17974.1, AW049097.1, AW011890.1, AI845946.1, AU019569.1₎ AU019107.1, C78223.1 , C78213.1₎ C77722.1, AA048547.1, AA986561.1, AI154454.1 , AW700938.1, AL137142.8, ACOl 1966.3, AC027326.2, AC027323.2, AC010622.3, AC020999.4, AC018938.3, AC018104.1, AC004390.1, AL161779.7, AP001547.1, AP000635.1, AP000610.2, AC022101.3, AC010093.3, ACOl 1799.5, AC023003.2, AC018466.3, AC020183.1, AC014557.1 , AC015076.1, AC009849.6, ACOl 1758.5, AC025391.3, AC022516.3, AC044816.2, AC026911.2, AC022462.3, AC015684.3, AC009835.5, AC015714.4, ACOl 1227.3, AC010018.4, AL355575.2, AL133344.21, AL157687.2, AL034359.4 SEQ ID NO. 110 NGO-Br-38 MK249/T7 3'

AF039695.1 , D86956.1 , NM_006644.1 , AB003334.1 , AB003333.1, Z47807.1 , D67017.1 , D67016.1 , AB005282.1 , NM H3559.1, L40406.1, ACOl 1661.5, AE003611.1, AL035259.1, AC004684.2, AE003571.1, AE003567.1, AC010168.6, AF140273.1, U32370.1, U30930.1, AC002367.1, AE000823.1, AC002292.1, AL158059.2, AJ006409.1, AB026658.1,

AF218257.1 , AC016752.2, AC009155.3, AC006413.3, U09675.1, AC005927.2, AC007061.5, AF030694.2, AF222716.1, U95740.1, AC009501.3, AC005083.1, AC007590.1, AF104919.1, AF074946.1 , AF030693.1, AF030692.1, AC005324.1, AL133419.15, AL034556.3, AL034560.3, ALl 10502.1, AL049779.4, AL049188.3, U27707.1, U40933.1, U41018.1, AB004275.1, AP000069.1, AB006696.1, Z18921.1, AB006689.1, AA543054.1, AA843693.1, AW612980.1, AI582881.1, AW612983.1 , AI378269.1 , AI920808.1 , AI654608.1 , AI742981.1, AI312753.1 , AI753470.1 , AI831339.1 , AI819251.1 ,

AI803588.1, AI751853.1, AI563996.1 , AWl 17974.1, AI668853.1, AA993280.1, AA632202.1, AA219263.1, AW627645.1, AW015796.1, AI337175.1, AI123280.1, AA912023.1, AA761750.1, AW027050.1, AI223412.1, AA535277.1, AA485151.1, AA166716.1, AW236067.1, AI369932.1, AI250881.1, AA482770.1 , AA933881.1, AI262020.1 , AI050716.1 , AI493255.1 , AA678506.1, AA582157.1, AW340810.1, AI673134.1, H52653.1, T58153.1 , AW068948.1 , AI361237.1₎ AA810686.1, T36072.1, F22410.1 , AW837156.1 , AA417317.1, AA082043.1, D58216.1, D29622.1, AA278231.1,

AW020035.1, AI612928.1 , AI630481.1, AA730742.1 , D29371.1, AA731716.1, AA417255.1, AA804371.1, AA465183.1, AA233888.1, AA780104.1, AA491870.1, AI357434.1, AW381433.1, AW163535.1, T34783.1 , Tl 0428.1, AW381418.1, Z41841.1, AW771160.1 , F03714.1, AI799265.1, AI582484.1, AI288972.1, AW059721.1, AA773435.1, AW470142.1, AI651 186.1, AI223825.1, AA232636.1, T34627.1, Z20100.1 , Z21220.1, AI658961.1, AA136424.1, AW824279.1, ALl 17974.1, AW049097.1, AI845946.1, C78213.1, AA048547.1, AA986561.1, AW700938.1, AL137142.8, ACOl 1966.3, AC018938.3, AC019338.4, AC018104.1, AP001547.1, AP000635.1, AP000610.2, AC022101.3, AC067877.1, AC018700.3, AC010093.3, AC008107.2, AC022636.3, ACOl 1799.5, AC009919.2, AC014557.1 , AC015336.1 , ACOl 5076.1 , AL354655.3, AL353639.2, AL161449.2, AC025440.3, AC022516.3, AC008395.5, AC027149.2, AC019075.6, AC067945.1, AC02691 1.2, AC023461.2, AC025246.5, AC0551 17.1, AC027646.3, AC015714.4, AC026641.1 , AC006281.6, AC018934.2, AC009015.2, AC002043.1, AC023302.2, AC006763.1, AC006187.1, AL139318.2, AL132640.1, AL138776.2, AL136303.3, AL049183.5, AL034359.4, AP000840.1,

SEQ ID NO. I l l NGO-Br-38 M 41 10/T3 5'

NM_006644.1, AB003334.1, AB003333.1, D86956.1, AF039695.1, D67017.1, D67016.1, Z47807.1, NM_013559.1, L40406.1, AB005267.1, AB023420.1, L12723.1, X67643.1, NM_008300.1, ACOl 1013.17, D85904.1, AF077354.1 , NM H4278.1, NM_011020.1, U23921.1, AB023421.1, D49482.1, AB005268.1, NM_004455.1, U67191.1, AC006661.2, AE003724.1, U95739.1 , AW137489.1 , AW665093.1 , AL120219.1, AI052062.1, AI023309.1, AU077146.1, AI052577.1, AA219339.1, AI003212.1, AA078767.1, AL043449.1, AW475538.1, AW227137.1, AW105834.1, AI931227.1, AI787816.1, AI746652.1, AI006526.1, AW209689.1, AU066691.1, AA 168224.1 , AA081692.1, AW069322.1, AW318627.1, AI956324.1, AI956249.1, AI316935.1, AA408320.1, AW227160.1, AA407914.1, AL044212.1, AA226851.1, AW141567.1, AA840049.1, AA726333.1, AW416815.1, AI087282.1, AI510184.1, AA799078.1, AA038974.1, AW281373.1, AW249190.1, AW174950.1, AW140856.1, AI777243.1, AI717978.1, AI667993.1 , AI593889.1 , AI564662.1 , AI548407.1, AI132100.1, AA798531.1, AA657153.1, AA309538.1, AA010464.1, W52045.1, W39574.1. N77720.1, AL137142.8, AL138965.3, AC046137.3, AC020834.2, AC015501.3, AC021286.3, AC068888.1, AC008686.5, AC023175.1, AC027676.2, AC044785.1, AC015810.3, AC009972.4, AC006091.9, AC017374.1, AC006802.1, AL354832.2, AL354813.2, SEQ ID NO. 112 NGO-Br-38 M 447/T3 5'

AC004079.1, AL023812.1, AFl 16671.1, AC010739.3, NM_000146.1, AF147331.1, AL031670.6, Z94054.1, L37679.1, M12938.1, M11147.1, X03743.1, M10119.1, AW516833.1, AW300978.1, AWl 62231.1 , AV257466.1, AW157374.1, AW079316.1 , AW009956.1 , AW004961.1, AI962098.1 , AI815894.1 , AI755008.1 , AI748966.1 , AI718110.1 , AI709101.1, AI672960.1, F19164.2, AI589785.1, AI583347.1, AI479061.1, AI420287.1 , AI361309.1, AI354529.1 , AI2921 1 1.1, AI219615.1, AI219349.1, AI214612.1 , AI200269.1, AI193445.1, AI189444.1, AI184382.1, AI143808.1, AI127965.1 , AI127854.1, AI093293.1, AI089317.1, AI015377.1, AA989142.1, AA970214.1, AA946915.1, AA928899.1 , AA918624.1, AA876284.1 , AA861967.1, AA857441.1, AA854288.1 , AA845736.1, AA838065.1, AA838024.1, AA775012.1, AA757403.1, AA658536.1, AA654568.1, AA618051.1, AA604054.1, AA600804.1, AA588452.1, AA587371.1, AA587071.1, AA582703.1, AA582484.1, AA582386.1, AA568291.1, AA564050.1, AA555249.1, AA541585.1, AA533130.1, AA531161.1, AA515081.1, AA494515.1, AA486095.1, AA468679.1, AA399366.1, AA373996.1, AA342114.1, AA223994.1 , AA206785.1 , AAl 92374.1 , AA 187220.1 , AA 152396.1 , AA085100.1 , AA083345.1 , AA057726.1, AA039420.1, AA028129.1, AA011234.1, W40483.1, W40152.1, N79615.1, N53835.1, N42345.1, N25279.1, H66026.1, R97999.1, D51234.1, H22588.1, R28740.1, T60144.1, T19029.1, AC023169.3, AC021399.3, AC022015.2, AC016474.2, AC018910.4, AC024270.1, AC016185.1, AC021886.4, AC068615.2, AC068712.1, AC040169.2, AC026803.2, AC008749.4, AC022916.2, AC021554.4, AC027626.2, AC024616.1, AC009867.1, AL139824.12, AC003117.1, AL139158.1, AP001939.1, AP001374.1

SEQ ID N0.113

NGO-Br-38

MK447/T73'

AF039695.1, D86956.1, NM_006644.1, AB003334.1, AB003333.1, D67017.1, D67016.1, AB005282.1, NM_013559.1, L40406.1, Z47807.1, AF262041.1, AC000065.1, ACOl 1661.5, AL034560.3, AL035259.1, AC004684.2, AE003567.1, AC007049.8, AC005992.15, AC016752.2, AC006586.9, AC004165.2, AL133419.15, AL034556.3, ALl 17202.1, Z68116.1, AL049188.3, U27707.1, AJ010316.1, AP000555.1, AA843693.1, AA543054.1, AI742981.1, AW612980.1, AW612983.1, AI582881.1, AI378269.1, AI920808.1, AI751853.1, AI654608.1, AI819251.1, AI831339.1, AI753470.1, AI312753.1, AI803588.1, AI563996.1, AW015796.1, AW117974.1, AI668853.1, AA535277.1, AA993280.1, AA632202.1, AA912023.1, AW627645.1, AW027050.1, AI337175.1, Al 123280.1, AA761750.1, AI223412.1, AA219263.1, AW068948.1, AA482770.1, AA166716.1, AW236067.1, AA485151.1, AI369932.1, AI250881.1, AA933881.1, AI262020.1, AI050716.1, H52653.1, AA678506.1, AA582157.1, AI493255.1, AW340810.1, AW837156.1, AI673134.1, T58153.1, T36072.1, F22410.1, AA417317.1, AW020035.1, AI361237.1, AA278231.1, AA810686.1, AA730742.1, AA082043.1, D58216.1, D29622.1, AA233888.1, AI612928.1, D29371.1, AI630481.1, AA731716.1, AA417255.1, AA804371.1, AA465183.1, AA780104.1, AA491870.1, T34783.1, Z41841.1, AW771160.1, AI357434.1, AI799265.1, AI582484.I, AI288972.1, F03714.1, AW381433.1, AW381418.1, T10428.1, AW163535.1, Z21220.1, AW470142.1, AI651186.1, AI223825.1, AA232636.1, Z20100.1, T34627.1, AI658961.1, AA136424.1, AW059721.1, AW571648.1, AA773435.1, AW544862.1, AI790491.1, AU019107.1, C78223.1, All 15351.1, AW700938.1, AA238818.1, AL137142.8, AC010034.5, ACOl 1966.3, AC027326.2, AC018938.3, AC018104.1, AC004390.1, AP000635.1, AP000610.2, AC068643.5, AC022101.3, AC020183.1, AC009849.6, AC018934.2, AL354895.3, AL353639.2, AL133344.21, ALl 57687.2, Z98865.1 , Z92818.1,

SEQ ID NO.114 NGO-Br-38 MK633/T3 5'

NM_006644.1, AF039695.1, AB003334.1, AB003333.1, D86956.1, D67017.1 , D67016.1, Z47807.1, NM_013559.1, L40406.1, AB005282.1, AB005281.I, AB005280.1, AB023420.1, X67643.1, NM_008300.1, D85904.1, AE003525.1, AL163279.2, AL109620.4, AF193508.1, AE003720.1, AE003589.1, AE003522.1, AC009223.2, AC004251.1, AC002367.1, AL163234.2, AL161553.2, AL161539.2, AL139077.2, AL009183.10, AP001689.1, Z97336.1, AP000477.2, A1658961.1, AW571648.1, AW474070.1, AW608075.1, AW572452.1, AW385582.1, AW470142.1, AA232636.1, AW316651.1, AAl 66806.1, AI751852.1, AW771160.1, AW628153.1, AI651186.1, AA953645.1, AW820299.1, AA394027.1, AI223825.1, AA136424.1, AW390368.1, AI582484.1, AW103624.1, AW604836.1, AI337175.1, AI288972.1, AA435594.1, AA485036.1, F07487.1, AA571359.1, Z20100.1, F08794.1, AI799265.1, T63090.1, AW859988.1, AW859943.1, AA624532.1, AW820234.1, AI838486.1, AW609781.1, C81194.1, AW085874.1, AW820232.1, AA572403.1, AW020035.1, AA571473.1, T34627.1, Z21220.1, AA417317.1, AA278231.1, AA843693.1, AW389335.1 , Z41841.1 , AA079853.1 , AW491178.1 , AI842560.1 , AV275994.1 , AA777031.1, AA967441.1, AA856248.1 , AW837156.1, AA238818.1, H52653.1, T34783.1, AI751853.1, F03714.1, AW861588.1, AW819997.1, AW819755.1, AW604699.1, AW366794.1, AW085727.1, AW068948.1, AI925201.1, AI754819.1, AI567970.1, AA703912.1, AA493400.1, AA173193.1, R54223.1, AI115351.1, AW545353.1, AW545094.1, AW542227.1, AW537735.1, AW060626.1, AI956869.1, AV146133.1, AI528497.1, AA823019.1, AA799083.1, AA462732.1, AA445826.1, AW754207.1, AA205597.1, AW604696.1, AV279553.1, AV149067.1, AI600071.1, AL137142.8, AC012569.3, AP001895.1, AP001563.1, AC023471.2, AC018495.3, AC010070.5, AC010069.6, AC015410.1, AF129408.1, AC022797.3, AC021531.3, AC005506.6, AC021722.4, AC009039.5, AC007337.2, AC008361.7, AC014468.1, AL162502.2, AC034128.2, AC018700.3, AC022530.4, AC019267.3, AC009925.3, AC024681.2, AC022461.3, AL109916.3, ALI38705.3, AL161449.2, Z98863.1,

SEQ ID NO.115 NGO-Br-40 combined

NM_004120.2, M55543.1, AK001823.1, NM_002053.1, M55542.1, NM_010259.1, M63961.1, M55544.1, M80367.1, NM_010260.1, AF109168.1, AF077007.1, AJ007970.1, U44731.1, NM_008620.1, M81128.1, AC022522.2, AC006487.7, AL135749.2, X77129.1, Z95388.1, AC004930.1, AC005028.1, Z78546.1, NC_001143.1, AE003472.1, NM_000379.1, AF085699.1, AF178650.1, AC007980.1, AC005557.1, AC005669.1, ALl 09935.39, AL163226.2, AL133283.9, AL008639.15, AL121654.1, X92112.1, AP001681.1, ALl 17265.1, AB038490.1, U39487.1, AL035640.2, Z28127.1, X72016.1, U06117.1, Y10720.1, AP001137.1, AB015429.1, AB020867.1, D10044.1, Dl 1456.1, AW001215.1, AI830004.1, AW058212.1, AA876142.1, AI983562.1, AI439472.1, AW820994.1 , AW468007.1, AI969542.1 , AI760378.1, AW078537.1, AW614912.1, AW577433.1, AA075477.1, W37973.1, AI870195.1, AW804484.1, AI906045.1, AI859339.1, AA622193.1, AW341927.1, W37755.1, AI500511.1, AA642656.1, AI492530.1, AI902944.1, AI500507.1 , AA837842.1, AI865686.1, AA075671.1, AA131850.1, AA635989.1, AA587444.1, AW297239.1, AI285460.1, AW804456.1 , AW821048.1, AI862178.1, AW793466.1, AI922648.1, AA937007.1 , AA903286.1, AW373870.1, AI289455.1, AI251115.1, AA533156.1 , AI084027.1 , AW368079.1 , AA627607.1 , AW362711.1 , AA532369.1 , AA579973.1 , AW815880.1, AA586545.1, AA917383.1, AW026936.1, AI138455.1, W72748.1 , T29528.1, AI962517.1, AI795779.1, AI073859.1, AW797814.1, AW578905.1, AI371522.1, AA044192.1 , AW861558.1, AW609821.1, AW797815.1, AI702366.1, AA471169.1, AI683358.1, AI528561.1 , AW320458.1, AA424070.1 , AA164464.1, AI989871.1, AW474440.1, AI683206.1, AA122936.1, W01896.1, AA880099.1, AA100063.1, AW211765.1, AI905784.1, AI9057I9.1, AA305909.1, AI811907.1, AW797793.1, AW629741.1, AA354725.1, H05350.1 , AW817431.1, AA486849.1, F06345.1 , AW239153.1 , AA174655.1, AA347633.1, AA315174.1, AA487747.1, AL161639.4, AL160008.1, AL139416.1, AL138786.3, AC021689.2, AL355818.2, AC060233.1, AC021626.3, AC009729.4, AC026091.3, AC010872.4, AL138889.2, AP000831.1, AC013475.4, AC024551.3, AC024150.5, AC060776.2, AC063963.3, AC008373.6, AC010630.3, AC034166.2, AC021399.3, AC025799.2, AC016190.3, AC025482.2, AC027133.1, AC022015.2, AC024303.2, AC018807.4, AC016720.4, AC016696.4, ACOl 1210.3, AC016474.2, AC019071.2, AC010118.5, AC010743.4, AC017393.1, U82205.1, AL158849.7, AL356126.1, AL158070.2, AP001809.1,

SEQ ID NO. 116 NGO-Br-40 MK121/T3 5'

NM_004120.2, M55543.1, NM_002053.1, M55542.1, AKOO 1823.1 , NM_010259.1, M63961.1, M55544.1, M80367.1, NM_010260.1 , AF109168.1, AF077007.1, AJ007970.1 , U44731.1, NM_008620.1, M81128.1, X77129.1. Z95388.1, Z78546.1, AE003629.1 , AE003472.1, AF085699.1, AC007980.I , AC005557.1, AL133283.9, AL008639.15, X92112.1 , ALl 17265.1, AB015429.1, AF257304.1, AF257303.1, AE003459.1, AC007177.1, U69633.1, ALl 17319.1, AL031587.3, AW297239.1 , AI962517.1 , AI795779.1 , AW320458.1 , AI528561.1, AW368079.1 , AA424070.1 , AAl 22936.1 , AA880099.1 , AAl 00063.1 , AW21 1765.1 , AA305909.1 , AW36271 1.1 , AW629741.1, AA354725.1 , AW815880.1 , AW239153.1, AA347633.1, AA296543.1, AA709608.1, AA337079.1, AA91 1189.1 , AA873192.1, F14838.1, AU076892.1, AA576498.1, AWl 06727.1 , AA878690.1, W77927.1, AW428394.1 , AA296485.1, AI906045.1, AA131850.1, AW820809.1 , T83604.1, F14828.1, AA487747.1, AW669464.1, AW817439.1, AW609764.1, AA158924.1, AU076806.1, T75545.1, AW817360.1 , AI980812.1, AI626652.1, AA848004.1, W13273.1, AI979397.1 , AI529783.1, AI194988.1, AA889865.1 , C05965.1, R54285.1, R54280.1, F06574.1 , T34309.1, T32678.1, AW399587.1, AW398501.1, AA955194.1, C77542.1, AL161639.4, AL160008.1, AL139416.1, AC021689.2, AL138786.3, AL355818.2, AC021626.3, AC010872.4, AC024551.3, AC060776.2, AC063963.3, AC021399.3, AC025482.2, AC022015.2, AC007147.7, ACOl 1210.3, AC016474.2, AC0101 18.5, AC020189.1 , AC017393.1, U82205.1, AL356126.1, AC026877.4, AC064824.2, AC053519.2, AC027322.2, AC008494.7, AC016942.4, AC010289.3, AC019282.2, AC027620.3, AC023888.6, AC037442.1, AC026047.2, AC013693.3, AC021769.3, AC020577.1, AC019338.4, AC013718.3, AC015469.2, AC023823.2, AC013415.3, AC020230.1, AC021758.1, AC016495.1, AC013276.2, AC013485.1, AC012667.1, AC007515.1 , AL355532.4, AL356008.1, AL354918.3, AL079302.3, AP002010.1, AP001807.1, AP001642.1, AP001638.1, AP001461.2, AP001324.1, AP001104.1,

SEQ ID NO.117 NGO-Br-40 MK121/T7 3' NM_004120.2, M55543.1, AK001823.I , NM_002053.1, M55542.1, NM H0259.1, M63961.1, M55544.1 , M80367.1, NM_010260.1, AF109168.1 , AF077007.1, AJ007970.1, AC022522.2, AC006487.7, AC005028.1, AL163226.2, AL121963.10, AP001681.1, AL035640.2, Y10720.1, AP001 137.1, AC007236.4, AC018769.2, NM_007199.1, AF178650.1, AFl 13136.1, AC006241.1, U78259.1, AL163235.2, AL135749.2, AL109984.14, AP001690.1, AP000476.2, AB005234.1, AW614912.1, AI830004.1, AW001215.1, AA876142.1 , AW058212.1, AI760378.1, AI439472.1, AW078537.1, AI983562.1, AA075477.1, AI870195.1, AA622193.1, AW341927.1 , W37755.1, W37973.1, AA642656.1, AI492530.1, AI500507.1 , AA837842.1, AI865686.1, AA587444.1 , AA635989.1, AI285460.1, AI862178.1, AA937007.1, AA903286.1 , AI289455.1 , AA533156.1, AI084027.1 , AA627607.1 , AW373870.1 , AA075671.1, AA532369.1 , AA579973.1, AA917383.1, AW026936.1, AW793466.1, AI138455.1, T29528.1, AW577433.1, AI073859.1, AI371522.1, AI702366.1, AW609821.1, W01896.1, AI500511.1, AW468007.1, AI969542.1, AI859339.1, AI922648.1 , AA586545.1, AA487528.1, AA315174.1, AI081732.1, AI075062.1, AA937600.1, AW449506.1, AA827350.1, AAl 31800.1, AA810201.1, AA650178.1, AI280597.1, AA424529.1 , AW799191.1 , AI910674.1, AA486850.1, AA837672.1, AA834863.1, AI905784.1, AI905719.1 , AI861968.1, AI251115.1, AW817431.1, AW304126.1, AA564905.1, AA056488.1 , AW363341.1, AW805514.1, AW796865.1, AW804484.1, AA424397.1, AI372935.1, AA587703.1, H05300.1, AI246407.1, AW820994.1, AW799183.1, W37972.1, AW821048.1 , AW470713.1 , AW363352.1, AW797212.1, AI760921.1, AI007134.1, AA175795.1, AA139382.1 , AI386222.1, AI036133.1, AA153027.1, AA153021.1, AL161639.4, AL139416.1, AL160008.1, AC060233.1, AC026091.3, AC013475.4, AC025799.2, AC012246.3, AC016190.3, AC027133.1, AC022895.2, AL121573.10, AL355373.1, AC012264.8, AC022330.9, AC018461.18, AC026777.2, AC026737.3, AC026704.3, AC022418.3, AC010230.3, AC009051.5, AC009050.4, AC025073.2, AC027110.2, AC027630.4, AC027453.2, AC010159.7, AC027168.2, AC026590.2, AC015972.3, AC021149.4, AC025790.2, AC021688.2, AC018807.4, AC016686.4, ACOl 1864.3, AC024403.2, AC024278.1, AC021339.3, AC013725.2, AC018408.1, AC013404.1, AC012545.1 , AL162497.6, AL139275.6, AL139274.6, AL136380.2, AL355820.2, AL157818.2,

SEQ ID NO. 118 NGO-Br-40 M 221/T3 5'

NM_004120.2, M55543.1 , NM_002053.1 , M55542.1, M80367.1, NM H0259.1, M63961.1, M55544.1, AK001823.1 , NM_010260.1, AF109168.1, AF077007.1, AJ007970.1, U44731.1, NM_008620.1, M81128.1, X77129.1, Z95388.1, AC004930.1, NC_001143.1, AF085699.1, AC007980.1, AC005669.1, AL109935.39, AB038490.1, Z28127.1, X72016.1, AB015429.1, AB020867.1, NM_001567.2, AC005917.2, AE003603.1 , NM_013134.1, NM_006460.1, AC006312.8, AC004798.1 , AC003111.1, AL161516.2, AL133304.2, AL049487.1, L36818.1, Y14385.1 , AB021179.1 , M29249.1 , X93922.1, AI906045.1, AA131850.1, AW368079.1, AW362711.1, AW815880.1 , W72748.1, AW297239.1 , AW820994.1, AI902944.1, AW578905.1, AW861558.1, AA044192.1, H05350.1, AA486849.1, F06345.1, AW804456.1, W77927.1, AW821048.1, AW804484.1, AI969542.1, AI962517.1, AI683358.1, AA911189.1, AA164464.1, AW468007.1, AI989871.1 , AI528561.1 , AW474440.1 , AI683206.1 , AA878690.1 , AA487367.1 , F07031.1, A W804431.1, A A487747.1 , AI905784.1 , AI905719.1, AA873192.1, AI922648.1, AW320458.1, AW211765.1, AA122936.1, AW820809.1, AW106727.1, AA174655.1, T83604.1, T75545.1 , AW817439.1 , AW609764.1, AI81 1907.1, AW817360.1, AA610352.1, F05698.1 , AI859339.1, AW797814.1, AA471169.1, AA880099.1, AW577433.1, AI50051 1.1, AA044017.1, T87056.1, AI922921.1 , AA848004.1, AA5O6001.1, AV362793.1, AA582749.1, W13273.1, AI651570.1, AI075062.1, AA690573.1, AA665504.1, AA057242.1, AW665096.1, AW454822.1, AL135036.1, AW166154.1, AI811680.1, AI796944.1,

AV046437.2, AA955194.1, AI383864.1, AI216433.1, AA928789.1, AA927260.1, AA909971.1, AA890309.1, T43327.1, AA719024.1, C77542.1, AA099506.1, N33318.1 , N21081.1, R65420.1, H36685.1, H16325.1, T41892.1 , Z44502.1, AL161639.4, AL160008.1, AL139416.1 , AL138786.3, AL355818.2, AC021689.2, AL137851.3, AP000831.1, AC024150.5, AC034166.2, AC024303.2, AC016696.4, ACOl 1860.3, AL158849.7, AL158070.2, AC036129.2, AC021630.4, AC018354.6, AC012053.2, AC025975.2, AC027743.1, AC024047.2, AC026047.2, AC025865.2, AC013612.3, AC022854.3, AC022679.3, AC020753.2, AC018814.3, AC018497.4, AC023201.2, AC006295.8, AC013759.2, AC017228.1, AF166490.1, AL354770.2, AL356008.1, AL355990.1, AL161658.3, AL160006.2, AP001385.1, AP001157.1, AP000812.I , AP000593.1, AP000485.2, SEQ ID O.119 NGO-Br-40 MK221 T7 3'

NM_004120.2, M55543.1, AK001823.1, NM_002053.1, M55542.1, NM_010259.1, M63961.1, M55544.1, M80367.1 , AC022522.2, NM_010260.1, AF109168.1, AF077007.1, AJ007970.1, AC006642.1, U28927.1, AL163226.2, AL049555.6, AP001681.1 , U40937.1, AP001137.1, AE002269.1, AC006241.1, AC004558.1, AF052729.1, AL163235.2, AP001690.1, Y10720.1, AP000476.2, AB005234.1, AB026654.1, M97632.1 , AA876142.1 , AW001215.1, AI830004.1, AW614912.1, AW058212.1, AI760378.1 , AI439472.1, AW078537.1, AI983562.1, AA075477.1, AI870195.1, AW341927.1, AI492530.1, W37755.1, AA622193.1, W37973.1, AA642656.1 , AI500507.1, AA837842.1 , AI865686.1 , AA635989.1, AI862178.1, AA587444.1, AI285460.1, AA937007.1, AA903286.1 , AI289455.1, AA533156.1, AA627607.1, AI084027.1, AA532369.1, AA579973.1, AW373870.1, AA917383.1, AA075671.1, AW026936.1, AI138455.1, AI073859.1, AW793466.1, T29528.1, AI702366.1, AW577433.1, AI371522.1 , W01896.1, AW609821.1, AI5005U .1, AW468007.1, AI969542.1, AI859339.1, AI922648.1 , AA586545.1 , AI280597.1 , AA 131800.1 , AA487528.1 , AA315174.1 , AW796865.1 , AI081732.1 , AI075062.1 , AW449506.1, AA937600.1, AI905784.1, AI905719.1, AI251115.1, AA827350.1, AW817431.1, AW799191.1, AI910674.1 , AA810201.1 , AA650178.1 , AA486850.1 , AW804484.1, AA424529.1, AA837672.1, AA834863.1, AI861968.1 , AW304126.1, AA564905.1, AA056488.1, AW805514.1, AW363341.1, AA424397.1, AW820994.1,

AI372935.1, AI246407.1, AI400402.1, AA587703.1, AW799183.1 , AW804508.1, W37972.1, AW821048.1, AW799555.1 , AW797212.1, AI760921.1 , AA947554.1, H05300.1, AI007134.1, AA175795.1, AA139382.1, AL161639.4, AL139416.1, AL160008.1, AC026091.3, AC013475.4, AC027453.2, AC016190.3, AC021 149.4, AC027133.1, AC021688.2, AC016774.2, AC006883.2, AC022330.9, AC018461.18, AC022418.3, AC010230.3, AC009051.5, AC009050.4, ACOl 1784.3, AC027168.2, AC009625.3, AC026590.2, AC015972.3, AC016686.4, AC024403.2, AC013404.1, AC012545.1, AL139275.6, AL139274.6, AL354758.3, AL157714.3, AL160058.3, AL157818.2, AL158072.2,

SEQ ID NO.120 NGO-Br-40 M 241/T3 5'

NM_004120.2, M55543.1, NM_002053.1, M55542.1, AK001823.1 , NM_010259.1, M63961.1, M55544.1, M80367.1, NM_010260.1, AF109168.1, AF077007.1, AJ007970.1, U44731.1, NM_008620.1, M81128.1, AC0061 12.2, X77129.1 , Z95388.1, Z78546.1, AE003472.1, AC004969.1, AC005053.1, AC005061.2, AF085699.1, AC007980.1, AC005557.1, AL109935.39, AL133283.9, AL008639.15, X921 12.1, ALl 17265.1, AB015429.1, AB020867.1, AF257304.1, AF257303.1, AE003459.1, NM_013134.1, AC007177.1, AC004798.1, AC003111.1, AF003626.1, U69633.1, ALl 17319.1, AL034426.4, AL031587.3, U29614.1, M29249.1 , AW297239.1 , AW368079.1, AI962517.1, AW362711.1, AW815880.1 , AI795779.1, AI528561.1 , AW320458.1, AA122936.1, AA880099.1, AA424070.1 , AW211765.1, AA100063.1, AA305909.1, AA354725.1, AI906045.1, AW629741.1, AA131850.1, AA347633.1, AW239153.1, AA709608.1, AA296543.1, W77927.1, AA911189.1 , AA878690.1 , AA873192.1 , AA337079.1 , F14838.1 , AWl 06727.1 , AA576498.1 , W72748.1 , AW428394.1 , AI905784.I , AI905719.1, AW820809.1, AA487747.1, T83604.1, T75545.1, AW817439.1, AW609764.1, AA296485.1, AW817360.1, F14828.1, AW578905.1, AW861558.1, AW669464.1, AA158924.1 , AU076892.1, AI626652.1, AI979397.1, AI922921.1, AI980812.1, AA848004.1 , AA506001.1 , AA582749.1 , W13273.1, AI651570.1, AI529783.1, AI194988.1, AA889865.I , C05965.1, R54285.1, R54280.1 , F06574.1, T34309.1 , T32678.1, AW399587.1 , AW398501.1, AW256377.1, AV046437.2, AA955194.1, C90826.1, C77542.1, AL161639.4, AL160008.1, AL139416.1, AC021689.2, AL138786.3, AL355818.2, AC021626.3, AC007223.1, AC010872.4, AC024551.3, AC060776.2, AC063963.3, AC034166.2, AC021399.3, AC025482.2, AC022015.2, AC024303.2, AC016696.4, ACOl 1210.3, AC016474.2, AC0101 18.5, AC020825.2, AC019249.3, AC017393.1, U82205.1, AL356126.1 , SEQ ID NO.121 NGO-Br-40 MK241 T7 3'

NM_004120.2, M55543.1 , AK001823.1, NM_002053.1, M55542.1, NM_010259.1, M63961.1, M55544.1, M80367.1 , NM_010260.1, AF109168.1, AF077007.1, AJ007970.1, AC006487.7, AC005028.1, AF235093.1, AC022522.2, U97404.1, AL163226.2, AL163210.2, AP001681.1, AJ010598.1, AL035640.2, AP001137.1, AE002269.1, NM_007199.1, AFl 13136.1, AC006241.1, U41556.1, AL163235.2, AL109984.14, Z82288.2, Z81102.1, Z70285.1, APOO 1690.1, U37429.1, Y10720.1, Z73419.1, AP000476.2, AB005234.1, AW614912.1, AI830004.1, AW001215.1, AA876142.1, AW058212.1, AW078537.1, AI760378.1, AI439472.1, AA075477.1, AI870195.1, AI983562.1, AI492530.1, AW341927.1, AA622193.1, W37755.1, AI500507.1, AA642656.1, AA837842.1, AI865686.1, W37973.1, AA635989.1, AI862178.1, AA587444.1, AI285460.1, AA903286.1, AA937007.1 , AI289455.1 , AA533156.1, AI084027.1, AA532369.1, AA627607.1, AA579973.1, AA917383.1, AW026936.1, AI138455.1, AW373870.1, AI073859.1, AA075671.1, AI371522.1, AI702366.1, W01896.1 , AW793466.1 , T29528.1 , AW577433.1 , AW609821.1, AI922648.1 , AA 131800.1 , AI280597.1 , AI500511.1, AA487528.1 , AA315174.1 , AW468007.1 , AI969542.1 , AI859339.1 , AW449506.1 , AI081732.1 , AI075062.1 , AA937600.1 , AA486850.1, AW799191.1, AI910674.1, AA837672.1, AA834863.1, AA827350.1, AA810201.1, AA650178.1, AA424529.1, AW796865.1, AW304126.1, AI861968.1, AA564905.1 , AA056488.1, AA586545.1 , AW363341.1,

AI246407.1, AA587703.1, AI372935.1, AW805514.1, H05300.1, AA424397.1, AW799183.1 , AW470713.1 , AI905784.1 , AI905719.1, AW817431.1, AW797212.1, AI251115.1, AI400402.1, AI760921.1, AW804484.1, AW820994.1, AA947554.1, AI007134.1, AA175795.1, AA139382.1, AW821048.1, AA153021.1, AI386222.1, AA153027.1, W37972.1 , AL161639.4, AL139416.1, AL160008.1, AC060233.1, AC026091.3, AC013475.4, AC025799.2, AC016190.3, AC063948.3, AC012264.8, AC024102.5, AC018461.18, AC026737.3, AC026704.3, AC022418.3, AC027630.4, AC027168.2, AC026590.2, AC026549.2, AF235106.1, AC015972.3, AC034223.1, AC012148.2, AC025790.2, AC008248.2, AC009256.7, AC024403.2, AC020798.2, AC022290.2, AC013404.1, AC008031.3, AC012545.1, AL139275.6, AL139274.6, AL136380.2, AL355820.2, AL162421.1, SEQ ID NO. 122 NGO-Br-40 MK255/T7 3'

NM_004120.2, M55543.1, AK001823.1, NM_002053.1, M55542.1, NM_010259.1 , M63961.1, M55544.1, M80367.1, NM_010260.1, AF109168.1, AF077007.1 , AJ007970.1 , AC022522.2, AC006487.7, AL135749.2, AC005028.1, AL162873.1, AE003782.1, AL163226.2, AP001681.1, AL035640.2, AP001137.1, ABOl 1093.1 , AF227618.1 , AE002269.1, AC007347.3, NM_007199.1, AFl 13136.1, AC006241.1, AL163235.2, AC002094.1, AL133246.2, AL109984.14, Z49910.1 , APOO 1690.1 , X56844.1 , Yl 0720.1 , AP000476.2, AB005234.1 , AI830004.1 , AWOOl 215.1, AA876142.1, AW058212.1, AI760378.1, AW614912.1, AI983562.1, AI439472.1, AW078537.1, AA075477.1, AI870195.1, W37973.1, AA622193.1 , AI492530.1 , AW341927.1 , W37755.1 , AA642656.1 , AI500507.1 , AA837842.1 , AI865686.1 , AA635989.1 , AA587444.1, AI862178.1, AI285460.1, AA903286.1, AA937007.1, AI289455.1, AA533156.1 , AW373870.1 , AI084027.1, AA075671.1, AA532369.1, AA627607.1, AA579973.1, AA917383.1, AW026936.1, AW793466.1 , AH 38455.1, AW577433.1 , AI073859.1, T29528.1, AI371522.1, AI702366.1, AW609821.1, AI50051 1.1, AW468007.1, AI969542.1, AI859339.1, W01896.1, AA586545.1, AI922648.1, AI905784.1 , AI905719.1, AI251 U5.1, AW817431.1, AA131800.1, AA487528.1, AA315174.1, AI280597.1 , AI081732.1 , AI075062.1, AW804484.1, AW449506.1, AA937600.1 , AA827350.1, AW799191.1, AI910674.1, AA810201.1, AA650178.1, AA486850.1, AA837672.1, AA834863.1, AA424529.1, AW304126.1, AI861968.1, AA564905.1, AA056488.1, AW820994.1, AW796865.1, AW804456.1 , AW797814.1, AI902944.1, AW797815.1, AW797793.1, AW363341.1 , AI372935.1 , AA587703.1 , AW805514.1, AI246407.1 , A W821048.1 , AA424397.1, H05300.1, AW799183.1, W37972.1, AW470713.1, AA175795.1, AA139382.1 , AA153021.1, AI386222.1, AA153027.1, AL161639.4, AL139416.1, AL160008.1, AC060233.1, AC026091.3, AC013475.4, AC008878.6, AC008373.6, AC010630.3, AC025799.2, AC016190.3, AC027133.1, ACOl 1764.5, AC014685.1,

SEQ ID NO.123 NGO-Br-40 MK303/T3 5'

NM_004120.2, M55543.1, NM_002053.1, M55542.1, AK001823.1, NM_010259.1, M63961.1, M55544.1, NM_010260.1, AF109168.1, AF077007.1 , AJ007970.1, M80367.1, AC004930.1, AL135749.2, AP000350.1, NC .001143.1, NM_000379.1 , AC002288.1 , AC005669.1 , AF077537.1 , ALl 21654.1 , U39487.1 , U39646.1 , Z28127.1 , X72016.1 , U06117.1 , D10044.1, Dl 1456.1, NM_001567.2, AC009890.12, AC010489.4, AC007048.4, AC005917.2, AC006832.2, AE003603.1, AE003479.1 , AC005781.1, AC002526.1, NM_006460.1, AF202730.1, AC003661.1, AC008125.9, U40939.1, AC007504.3, AC007785.1, L21934.2, AC004596.1, AC000028.1 , AC005837.1, U81031.1, AC005215.1, AC003047.1 , AC002094.1, AL161516.2, Z81088.1, AL049487.1 , L36818.1 , X15209.1, X15750.1, Y14385.1 , AB021179.1, A W820994.1 , AW804484.1 , A W468007.1 , AI969542.1 , AI902944.1 , AW804456.1 , AI922648.1 , AW821048.1 , AI859339.1. AI500511.1, AW577433.1, AI251 115.1, AW797814.1 , AW797815.1, AA471 169.1, AA044192.1, AI683358.1, AW861558.1 , AW578905.1, AA586545.1, AW001215.1, AW793466.1, AI989871.1, AI683206.1 , AW474440.1, AI906045.1 , AAl 64464.1, AA075671.1, AI830004.1, AI811907.1 , A W797793.1, AW058212.1, AI983562.1 , AA876142.1 , H05350.1 , AAl 31850.1 , W72748.1 , AI439472.1 , AA486849.1 , F06345.1 , AW804431.1 , AW373870.1, AA174655.1, AW817431.1 , AI905784.1, AI905719.1, F23076.1, AA044017.1, AA610352.1, AA487747.1, AW609821.1, AI760378.1, AW078537.1, AA487367.1, AW614912.1, T87056.1 , T29528.1, W37973.1, F07031.1 ,

W37972.1, AA263171.1, AI492530.1, AA424397.1, AI865686.1, AA487528.1, AA294979.1, AW138402.1 , AI386222.1 , AI180927.1, AI036133.1, AA184762.1, AA153027.1, AA153021.1, AV362793.1, AA315174.1, F05698.1, AW815880.1, AW363341.1, AW36271 1.1, AA622193.1, AA057242.1, AI796944.1, T41892.1 , AL161639.4, AL160008.1, AL139416.1, AL138786.3, AL355818.2, AC009158.3, AC024026.2, AL138782.5, AL138934.2, AL138889.2, AC024150.5, AC008373.6, AC010630.3, AC021689.2, AC048369.1, AC015803.3, AC019071.2, AC010743.4, AP001809.1,

SEQ ID NO. 124 NGO-Br-40 MK303/T7 3' NM_004120.2, M55543.1 , AK001823.1, NM_002053.1, M55542.1, NM_010259.1, M63961.1, M55544.1, M80367.1, NM_010260.1, AF109168.1, AF077007.1, AJ007970.1, AC022522.2, AC006487.7, AL135749.2, AC005028.1, AF178650.1, AL163226.2, AP001681.1, AL035640.2, Y10720.1, AP001 137.1, ACOl 1282.3, AE002269.1, AC006142.1, NM_011369.1 , NM_007199.1 , AFl 13136.1, AF017152.1, AC006241.1, AF064699.1, AF069670.1, AF069669.1, AF057284.1, AL163235.2, AC002094.1, AL109984.14, AL139296.2, AL121871.8, AL161581.2, AL136132.15, U86532.1 , AP001690.1 , AL034567.1 , X56844.1, AP000476.2, AB005234.1, L11794.1, LI 1777.1 , X99948.1, AW001215.1, AW058212.1, AI830004.1, AA876142.1, AI760378.1, AW614912.1, AI983562.1 , AI439472.1, AW078537.1, AA075477.1, AI870195.1 , AA622193.1, W37973.1, AW341927.1, W37755.1, AA642656.1, AI492530.1, AI500507.1, AA837842.1, AI865686.1, AA635989.1, AA587444.1, AI285460.1, AI862178.1, AA937007.1, AA903286.1, AI289455.1, AA075671.1 , AW373870.1 , AA533156.1 , AI084027.1 , AA627607.1 , AA532369.1 , AA579973.1 , AW793466.1 , AW577433.1, AA917383.1, AW026936.1, AI138455.1, T29528.1, AI50051 1.1, AI859339.1, AI073859.1 , AI969542.1 , AW468007.1, AI371522.1, AI702366.1, AW609821.1, W01896.1, AA586545.1, AI251 115.1, AI922648.1, AW804484.1, AW820994.1 , AI905784.1 , AI905719.1 , AW817431.1 , AAl 31800.1 , AA487528.1 , AA315174.1 , AI280597.1 , AI081732.1 , AI075062.1, AW449506.1, AA937600.1, AA827350.1, AW799191.1, AI910674.1 , AA810201.1, AA650178.1 , AA486850.1 , AA424529.1 , AA837672.1, AA834863.1, AI861968.1, AW796865.1, AW304126.1, AA564905.1, AA056488.1, AW804456.1, AI902944.1, AW363341.1, AW805514.1, AW821048.1, AI372935.1, AI246407.1,

AA587703.1, AW797815.1, AW797814.1, AA424397.1 , W37972.1, AW799183.1, H05300.1, AW470713.1, AI007134.1, AA175795.1, AA139382.1, AA153021.1, AI386222.1, AA153027.1, AL161639.4, AL139416.1, AL160008.1, AC060233.1, AC026091.3, AC013475.4, AC068832.1, AC008373.6, AC010630.3, AC025799.2, AC016190.3, AC027133.1, AC018807.4, AC016720.4, AC012444.3, AC036136.2, AC023395.2, AC012264.8, AC022330.9, AC053477.2, AC023347.3, AC018461.18, AC027820.2, AC032036.2, AC026737.3, AC026704.3, AC022418.3, AC010369.5, AC010230.3, AC010396.3, AC008780.4, AC009051.5, AC009050.4, AC027780.2, AC027630.4, AC060807.1, AC027168.2, AC009614.4, AC017106.3, AC026590.2, AC027646.3, AC040964.1, AC015972.3, AC025790.2, ACOl 1080.2, AC022247.2, AC024026.2, AC016686.4, AC024403.2, AC018408.1, AC013404.1, AC010874.2, AC012545.1, AL157771.3, AL139815.3, AL139275.6, AL139274.6, AL136380.2, AL355820.2, AL355886.1, AL354929.1, AL162453.4, AL096870.1, ALl 57818.2, AP002001.1 , AP001985.1, AP001388.1, AP001241.1 , AP001230.1,

SEQ ID NO. 125 NGO-Br-40 M 353/T3 5'

NM_004120.2, M55543.1, NM_002053.1, M55542.1 , AK001823.1, NM_010259.1 , M63961.1, M55544.1, NM_010260.1, AF109168.1 , AF077007.1 , AJ007970.1, M80367.1, AC004930.1, NC .001143.1, NM_000379.1, AC005669.1, AL121654.1, U39487.1, Z28127.1, X72016.1, U061 17.1, D10044.1. D11456.1, NM_001567.2, AC007048.4, AC005917.2, AC024882.1, AE003603.1, AE003479.1, NM_006460.1, AF202730.1, AC002565.1, AC008125.9, AC007785.1 , AF125463.1, AL163210.2, AL135749.2, AL132880.2, AL161581.2, AL161516.2, ALl 17204.1, Z81088.1, AL078588.9, AL117193.1 , AL034449.1, AL049487.1, AL034567.1, L36818.1, X15209.1, X15750.1, Y14385.1 , AB021179.1, A W820994.1 , AW804484.1 , AI902944.1 , AW468007.1 , AI969542.1 , AW804456.1 , AW821048.1 , AI922648.1 , AI859339.1, AI50051 1.1, AW577433.1, AI906045.1 , AI251115.1, AA131850.I , AW578905.1, AA044192.1, AW861558.1 , AW797814.1 , AW797815.1, AA471169.1, AI683358.1 , A A586545.1, AW001215.1, AW793466.1, AA164464.1, AI989871.1, AW474440.1, AI683206.1, AA075671.1, AI830004.1, AI811907.1, W72748.1, AW797793.1, H05350.1, AW058212.1, AI983562.1, AA876142.1, AA486849.1, F06345.1, AI439472.1, AAl 74655.1 , AW373870.1 , AW804431.1, AW817431.1, AA487747.1, F23076.1, AI905784.1, AI905719.1, AA610352.1, AW609821.1 , AA044017.1 , AI760378.1, AA487367.1, AW078537.1, W37973.1, F07031.1 , AW614912.1, T29528.1, T87056.1, W37972.1, AI492530.1 , AA263171.1, F05698.1 , AI865686.1 , AI386222.1 , Al 180927.1 , AI036133.1 , AAl 84762.1 , AA 153027.1 , AA153021.1, AW815880.1, AW362711.1, AW400386.1, AV362793.1, AW363341.1, AI075062.1, AA487528.1, AA424397.1, AA315174.1, AA294979.1, AA057242.1, T41892.1, AL161639.4, AL160008.1, AL139416.1, AL138786.3, AL355818.2, AC021689.2, AL138889.2, AL136985.1, AC024150.5, AC024038.5, AC019071.2, AC010743.4, AP001809.1, AC009770.4, AC023395.2, AC036129.2, AC027820.2, AC035140.2, AC008373.6, AC010630.3, AC008731.4, AC063979.1, AC017106.3, AC040911.1, AC024047.2, AC027362.1, AC012241.4, AC015975.3, AC006295.8, AC013759.2, AC017228.1, AC015394.1, AF166490.1, AC006916.1, AC006719.1, AL121796.4, AL353796.2, AL022594.18, AL035066.20, Z98858.1, Z98855.1, AL021573.1, AP001385.1, AP001157.1, AP000812.1, AP000593.1. AP000485.2, SEQ ID N0.126 NGO-Br-40 MK451/T3 5'

NM_004120.2, M55543.1, M80367.1, NM_010259.1, M63961.1, M55544.1, NM H0260.1, AF109168.1, AF077007.1, AJ007970.1, NM_002053.1, M55542.1, AK001823.1, AC004930.1, AF085699.1, AC007980.1, AL109935.39, X77129.1, Z95388.1, AB015429.1, AB020867.1, AC005103.3, NMJH3134.1, NM_006460.1, U44731.1, AF047825.1, AC004798.1, AC003111.1, AB021179.1, M29249.1, AI906045.1, AA131850.1, AW368079.1, AW362711.1, AW815880.1, W72748.1, AW297239.1, AW820994.1, W77927.1, AI902944.1, AW861558.1, AW578905.1, AA878690.1, H05350.1, AA044192.1, AA486849.1 , F06345.1 , AI905784.1 , AI905719.1 , AI528561.1 , AA911189.1 , F07031.1, AI962517.1 , AA873192.1 , AW474440.1, AW820809.1, AA487747.1, AI989871.1, AA487367.1, AA164464.1, AI683358.1, AI683206.1, AW320458.1, T83604.1, T75545.1, AW817439.1, AW609764.1, AW211765.1, AW817360.1, AA122936.1, AW821048.1, AW804484.1, AW804456.1, AW106727.1, AW804431.1, AI811907.1, AI922921.1, AA174655.1, AA848004.1, AA506001.1, AW468007.1, AV362793.1, AA582749.1, W13273.1, AI651570.1, AA880099.1, AW665096.1, AW454822.1, AW166154.1, AI811680.1, AI796944.1, AV046437.2, AA955194.1, AI383864.1, AI216433.1, AA928789.1, AA927260.1, AA909971.1, AA890309.1, AA719024.1, C77542.1, AA514692.1, AA099506.1, N33318.1, N21081.1, H16325.1, Z44502.1, AL161639.4, AL160008.1, AL139416.1, AL138786.3, AC034166.2, AC016696.4, AL158849.7, AC036129.2, AC018354.6, AC012053.2, AC021689.2, AC024047.2, AC026047.2, AC024303.2, AC020883.2, AC006295.8, AF166490.1, AL356008.1, AL161658.3,

SEQ ID NO.127 NGO-Br-41 MK264/T3 5'

NM_004602.1, AF061941.1, AF061940.1, AF061939.1, AF061938.1, AJ132258.1, NM_0l 1490.1, AF061942.1, NM_007344.1, X83973.1, AC004585.1, NMJM4865.1, NM_014393.1, AC004002.1, AC007542.2, AF038608.1, AC006064.9, U32712.1, AL121877.13, Y19062.1, AK002152.1, AK001576.1, X67320.1, AB015752.1, M31229.1, L04287.1, L03711.1, X68492.1, D63880.1, AC006142.1, AC010186.6, AC008078.11, AC004131.1, U46596.1, ALl 21775.2, AL096802.i l, AL034345.3, X89870.1, AP000497.1, AW351909.1, AW403841.1, AW836710.1, AW320695.1, AA240112.1, AA218774.1, AA270608.1, AW351905.1, AW141293.1, AA135261.1, U69197.1, H17179.1, T31173.1, T31172.1, AW581619.1, AAl 53656.1, T74327.1, W28253.1, AL045575.1, AA191685.1, R95466.1, AA209495.1, T06248.1, AA025528.1, AA285302.1, AW366804.1, AWl 53775.1, AI958903.1, AJ244015.1, AI386266.1, AI326431.1, AA562089.1 , AA 104976.1 , W82776.1 , AI353217.1 , AA813637.1 , AA700898.1 , AVI 82864.1 , AA918411.1 , AA890493.1, U25927.1, AV398409.1, AV344143.1, AW 123407.1, AA388686.1, AA156216.1, AL133174.11, AC063967.1, AC055879.1, ACOl 1492.5, AC051627.3, AC068845.1, AC016960.6, AC015624.2, AC069023.1, AC027538.2, AC025512.2, AC022909.4, AC015944.3, AC009842.7, AC015989.3, AC015809.2, AC022403.3, AC023263.2, AC012595.3, AC012161.7, AC006739.1, AL355854.1, AL160399.2, AL157885.2, AP001397.1,

SEQ ID NO.128 NGO-Br-41 MK264/T73' AJ132258.1_> NM_004602.1, AF061941.1, AF061940.1, AF061939.1, AF061938.1, AL109755.14, NM_011490.1, AF061942.1, AL163222.2, AP001677.1, AP000946.3, AC006717.1, AF196972.1, AE001740.1, AC005318.1, Z81142.1, AL031007.1, X06997.1, AC024077.2, AC007559.3, AC004988.2, AF134199.1, AC005520.2, AC006518.17, AF063866.1, AEOOl 142.1, AC005544.1, U47023.1, AF076274.1, AC004051.1, AC005337.1, AC004100.1, AL161946.1, AL161499.2, AL050326.3, AL022722.1, AB019438.1, L00608.1, L00607.1, L06312.1, L06135.1, X57002.1, X60725.1, X57001.1, X69496.1, D37813.1, AB009052.1, Y10614.1, AI983007.1, AI802592.1, AI190464.1, U69197.1, AA889669.1, AA157806.1, AI925182.1, AA846829.1, AA191622.1, AA609322.1, AA910279.1, AI333376.1, H16250.1, AA034036.1, AI557117.1, H11397.1, N45294.1, AW169049.1, AA907298.1, AI819766.1, N71642.1, AW263961.1, T15527.1, AI362641.1, AI472734.1, T89105.1, AI433939.1, AW183696.1, AA931425.1, AA594141.1, AA847184.1, AW105669.1, AA658226.1, AI419995.1, AW194431.1, AI340359.1, AA160287.1, N22707.1, AW576192.1, AI740524.1, AI017580.1, AL044093.1, AA858303.1, AA610333.1, AL044094.1, AI803720.1, AWl 66420.1, AW069464.1, AA903241.1, AI864144.1, AI216722.1, AI921819.1, AI190687.1, AA074277.1, N51259.1, F10050.1, AA427905.1, AI814813.1,

AA541311.1, H96787.1, AA904093.1, AA669068.1, AA206434.1, AI268881.1, AI150891.1, AI061243.1, AA747271.1, AA135198.1, AA593048.1, AA135111.1, AA207148.1, Z41528.1, AA135106.1, AW272442.1, AI963361.1, AW090441.1, AI262450.1, AA043331.1, T10553.1, Tl 1277.1 , AI138341.1, N66837.1, AI383429.1, N67513.1, N31181.1, D20243.1, AI868926.1, AA886271.1, AA578579.1, AW384062.1, AI160470.1, AA043332.1, AI687569.1, AI970644.1, T94064.1, AI799396.1, AA620459.1 , AA741223.1, AA090084.1, AW464265.1, AL133174. i l, ACOl 1492.5, AL158850.2, AC063967.1 , AC068736. I, AC009429.3, AC067887.2, AC024935.8, AC026678.4, AC021057.3, AC021056.3, AC025928.2, AC015929.4, AC013364.7, AC025738.1, AC022049.3, AC017061.3, AC021682.1, AL158840.4, AL133284.12, AC026333.2, AC013625.3, AC009047.4, AC012215.3, AC027402.2, AC007383.3, AC055805.1, AC019088.3, AC026588.2, AC015825.4, AC021186.2, AC022903.3, AC024732.2, AC015834.3, AC02101 1.2, AC022820.2, AC016930.5, AC010974.4, AC021980.1, AC009642.2, AC005282.1, AL139084.4, AL353709.1, AL354723.1. AP001394.1,

SEQ ID NO. 129 NGO-Br-42 combined

AC005069.2, ABOl 1102.1, L23077.1 , NM H3889.1 , AF017806.1, AP001253.1, AE001788.1, AL133417.10, AF262044.1 , AC008051.3, AF237670.1, AC021043.4, AF022974.1, L14730.1, AL031056.1, Z83313.1, AP001426.1, X01441.1, AB017192.1, AP000606.1, AB02561 1.1, AB018115.1, AL134426.1, AA972711.1 , AW157207.1, AW770787.1, AW468156.1, AW473852.1, AI266259.1, AA599244.1, AI817665.1 , AA837101.1 , AI377803.1, AW163183.1, AA527031.1, AA721095.1 , N33849.1, AA167375.1, AI572106.1, AI251893.1, AI241041.1, H84943.1 , AA279430.1,

AW609920.1, AA764886.1, AI699744.1, AA725331.1, AI302964.1, AI567039.1, AW379942.1 , AI593485.1, D52427.I , D55742.1, AI956843.1, AA210577.1, T10410.1, C01624.1, AA165991.1, AA825378.1, AI642382.I , AA611337.1, AW214633.1, AI551647.1, AW489266.1, AI467091.1, N85349.1, AA473146.1, AA167374.1, D55908.1 , AA471246.1, AI956621.1, AI606224.1 , AA726787.1 , R98544.1 , AA292113.1 , AA279626.1 , AW385669.1 , W45824.1 , AI810043.1 , H33984.1, R21996.1, AW416485.1, AV403226.1, AW260960.1, AW222072.1, AV227797.1, AW077780.1, AI820616.1, AV061748.1, AV042292.2, AI632719.1, AI423781.1, AI395491.1, AI014647.1, AA918760.1 , AA829983.1, AA395972.1, AA363407.1, AA274077.1, AL139274.6, AL160258.3, AL137180.3, AL138875.3, AL137000.3, AC025451.3, AC023608.1, AC023276.3, AC068334.1, AC027596.2, AC008276.2, AC006451.2, AC019240.4, AC005308.6, AC010109.4, AC014418.1, AL138727.2,

SEQ ID NO. 130

NGO-Br-42

MK182/T3 5'

AC005069.2, ABOl 1102.1, L23077.1, NM_013889.1 , AF017806.1, AL133417.10, AC004485.1, AC008082.12, AF022974.1, AE003628.1, AE003579.1, AE003420.1, ACOl 2654.2, AC000096.13, AC005137.1, AC003063.7, AC016163.4, AC006317.3, AC004973.1, AC007649.12, AC005454.1 , ALl 32976.2, AL122126.2, AC000392.1, AL121806.2, Z69838.1, AL022722.1, AL049571.1, U64875.1, AJ000521.1, D89336.1, AW163183.1, N33849.1, H84943.1, AA721095.1, AL134426.1 , AI642382.1, AA61 1337.1 , AA972711.1, AW609920.1, AW157207.1, AW770787.1, AA726787.1, AI266259.1, AI817665.1, AA837101.1, AA167375.1, N85349.1, AW473852.1, AI699744.1, AI251893.1, AW468156.1, AI572106.1, AA825378.1, AA764886.1, AA599244.1, AA165991.1, AA279626.1 , AI956843.1, AI593485.1, AI942680.1 , AV403226.1, AW334920.1, AW214633.1 , AV227797.1 , AW077780.1, AI820616.1, AI014647.1, AL139274.6, AL137180.3, AL160258.3, AC067751.1, AC026297.2, AC022907.3, AC016212.3, AC023608.1, AC069075.1, AC068778.3, AC044835.2, AC023276.3, AC069019.1 , AC021870.6, AC068334.1, AC008276.2, AC053489.1, AC021598.4, AC024718.3, AC019240.4, AC024646.2, AC005308.6, AC018580.4, AC024632.1, AC018519.3, AL158166.6, AL158158.4, AL157393.1 ,

SEQ ID NO. 131 NGO-Br-42 M 182/T7 3' AC005069.2, ABOl 1 102.1, L23077.1, NM_013889.1, AFO 17806.1 , ALl 63231.2, AP001686.1 , AP001253.1 , AE001788.1 , AF262044.1 , AF237670.1, AC021043.4, AE003478.1, AF229187.1, AC004658.1, AL163276.2, ALl 18512.8, L14730.1, Z83313.1, AP001731.1, AP001426.1, X01441.1, AB017192.1, AP000163.1, AB025611.1, AP000021.2, NC .001136.2, AC009415.2, AE003824.1, AC004460.1, NM_011261.1, AC008072.3, AC005046.3, AF115517.1, AC005467.1, U24703.1, AE000943.1, AL049834.3, AL049546.3, Z93374.1, AL021939.1, Z74123.1, X51895.1 , Z78583.1, D63520.1, AW157207.1, AA972711.1, AW770787.1, AW468156.1, AI266259.1, AA599244.1, AI377803.1, AA527031.1,

AI572106.1, AA279430.1, AA725331.1 , AI302964.1, AI567039.1, AW379942.1, D52427.1, D55742.1, AI593485.1, AI956843.1, T10410.1, AA210577.1, C01624.1, AA165991.1, AW214633.1, AI551647.1, AW489266.1, AI467091.1 , AA473146.1, D55908.1, AI606224.1, AW163183.1, R98544.1, AA2921 13.1, AW385669.1, W45824.1 , AI810043.1, H33984.1. R21996.1 , AW222072.1, AI632719.1, AI423781.1, AA829983.1, AA395972.1, AA274077.1, AA030373.1, W20048.1, AL139274.6, AL137180.3, AL160258.3, AL138875.3, AL137000.3, AC027490.3, AC025451.3, AC010432.4, AL137249.6, AC069145.1, AC069071.1, AC018473.9, AC006451.2, AC027189.2, AC023844.2, AC021677.3, AC010109.4, AL135932.4, AL137013.3, AC041025.2, AC01221 1.3, AC027600.1, AC024254.2, AC024026.2, AC023153.2, AC012369.2, AC018873.1, AF188032.1, AL139418.1, AP001813.1, SEQ ID NO. 132 NGO-Br-42 MK203/T3 5'

AC005069.2, ABOl 1102.1, L23077.1, NM_013889.1, AF017806.1, AC016678.4, AE003694.1, AE003528.1, AF063866.1, AP000606.1, AB0181 15.1, AC016749.4, AC019209.3, AE003706.1, AE003579.1, AE003462.1, AF240628.1, AC011284.3, AF224669.1, AC006317.3, AC005534.2, AC003037.1, U70823.1, AC004642.1, AL163224.2, AL049588.11, AL161516.2, AL161514.2, AL117386.1, AL078599.19, AL035693.19, Z81089.1, Z69838.1, Z95329.1, AL022722.1, AL035090.10, AP001679.1, AL049571.1, U64875.1, AJ000521.1, AL049482.1, L33820.1, L33819.1, AP001251.1, M76616.1, X61589.1, D89336.1, AP000001.1, AL134426.1, AW473852.1_> AA837101.1, AI817665.1, AA721095.1, AA167375.1, AI251893.1, AW609920.1, AI241041.1, AA764886.1, N33849.1, AI699744.1, H84943.1, AW163183.1,

AA825378.1, N85349.1, AI642382.1, AA611337.1, AA279626.1, AV424771.1, AW416485.1, AW260960.1, AV061748.1, AV042292.2, AL139274.6, AL160258.3, AL137180.3, AC026297.2, AC025494.2, AL109926.2, AC027596.2, AC020987.4, AC023957.3, AC016187.4, AC062033.1, AC025104.2, AC025526.2, AC022744.2, AC024632.1, AC022691.1, AC009818.4, AC010204.8, AC008250.15, AC020418.1, AC009588.4, AC012259.2, AC014418.1, AC007692.3,

SEQ ID NO. 133 NGO-Br-42 MK2410/T3 5' AC005069.2, ABOl 1102.1, L23077.1, NM_013889.1, AF017806.1, AC016678.4, AE003694.1, AF063866.1, AL049874.3, AP000606.1, AB018115.1, NC_001134.1, ACOl 6749.4, AE003831.1, AE003528.1, ACOl 1284.3, AF224669.1, U91318.1, AC006317.3, AC006004.1, AC005534.2, AC006221.1, U17503.1, U70823.1, AL049588.11, AL133512.10, Z69838.1, Z95329.1, AL035090.10, L33820.1, L33819.1, Z36160.1, X76053.1, AB020865.1, M76616.1, X61589.1, AP000001.1, AL134426.1, AW473852.I, AA837101.1, AI817665.1, AA167375.1, AI241O41.1, AI251893.1, AA721095.1, AW609920.1, AA764886.1, AI699744.1, AA825378.1, N85349.1, N33849.1, AA167374.1, AA471246.1, H84943.1, AI956621.1, AW163183.1, AI642382.1, AA611337.1, AV042292.2, AW646457.1, AW642567.1, AW416485.1, AW260960.1, AV061748.1, AI395491.1, AL139274.6, AL160258.3, AL137180.3, AL139223.2, AC016904.2, AC026297.2, AC025494.2, AC016469.4, AC012219.3, AC020987.4, AC023957.3, AC016187.4, AC025104.2, AC009818.4, AC010204.8, AC008250.15, AC020418.1, AC012259.2, AC007692.3, AL157389.3, AC037489.2, AC015846.3, AC037434.2, AF267167.1, AC023156.3, AC010543.4, AC009128.5, AC007716.2, AC009547.3, AC010902.3, AC019171.3, AC008271.3, AC018797.3, AC062007.1, AC026829.2, AC025656.2, AF235099.1, AC026225.2, AC025660.2, AC009562.5, AC021619.3, AC016667.2, AC007413.4, AC007330.5, AC012182.3, AC025348.1, AC010894.3, ACOl 1564.3, AC014418.1, AC013270.2, AC014124.1, AC010826.2, AC007414.4, AL162579.4, AL161647.5, AL157779.4, AL136311.3, AL355312.3, AL354893.3, AL136319.7, AL354711.1, AL157836.3, AL122125.1, AP001448.1, AP001023.1, AP000813.1, AP000675.1, AP000624.1,

SEQ ID NO. 134 NGO-Br-42 M 2410/T73' AC005069.2, ABOl 1102.1, L23077.1, NM_013889.1, AF017806.1, AL163231.2, AP001686.1, AP001253.1, AF262044.1, AF237670.1, AC021043.4, AE003478.1, AF229187.1, AC008072.3, AC004658.1, AL163276.2, ALl 18512.8, L14730.1, Z83313.1, AP001731.1, AP001426.1, X01441.1, AB017192.1, AP000163.1, AB025611.1, AP000021.2, NC_001136.2, AC009415.2, AC004460.1, AC005046.3, AFl 15517.1, AL049834.3, AL049546.3, Z93374.1, AL021939.1, Z74123.1, D00702.1, X51895.1, Z78583.1, AW157207.1, AA972711.1, AW468156.1, AW770787.1, AI266259.1, AA599244.1, AI377803.1, AA527031.1, AI572106.1, AA279430.1, AA725331.1, AI302964.1, AI567039.1, AW379942.1, D55742.1, T10410.1, D52427.1, AI593485.1, AI956843.1, C01624.1, AA210577.1, AA165991.1, AW214633.1, AI551647.1, AW489266.1, AI467091.1, AA473146.1, D55908.1, AW163183.1, AI606224.1 , R98544.1 , AA292113.1, AW385669.1, AW061815.1, H33984.1, R21996.1, AW728990.1, AW222072.1, AI810043.1, AI632719.1, AI423781.1, AA829983.1, AA030373.1, AL139274.6, AL137180.3, AL160258.3, AL138875.3, AL137000.3, AC027490.3, AC025451.3, AC010432.4, AL137249.6, AC069145.1, AC019230.3, AC034127.2, AC024687.3, AC006451.2, AC027189.2, AC020695.3, AC009407.3, AC021677.3, AC023095.2, AC010109.4, AC019599.1, AL135932.4, AL137013.3, AC069071.1, AC024223.7, AC018473.9, AC012323.4, AC024272.2, AC044797.2, AC027215.2, AC034298.1, AC016350.3, AC016031.2, AC027600.1, AC024254.2, AC024026.2, ACOl 1272.3, AC023153.2, AC013409.3, AC012369.2, ACOl 1231.3, ACOl 1619.2, AC016407.1, AF188032.1, AL121943.13, AL353786.2, AL161417.5, AL139418.1. AP001813.1,

SEQ ID NO. 135 NGO-Br-42 MK245/T73' AC005O69.2, ABOl 1102.1, L23077.1, NM H3889.1, AFO 17806.1, ALl 63231.2, AP001686.1, AP001253.1, AF262044.1, AF237670.1, AC021043.4, AE003478.1, AF229187.1, NM_011692.1, AC004901.1, U96760.1, AC004658.1, ALl 63276.2, ALl 18512.8, L14730.1, Z83313.1, X01441.1, AP001731.1, AP001426.1, AB017192.1, AP000163.1, AB025611.1, AP000021.2, AC005046.3, AC007887.8, AL032637.1, Z78016.1, AL031825.1, AL049546.3, AL031644.1, Z93374.1, AL021939.1, Z74123.1, Z68252.1, X51895.1, Z78583.1, AA972711.1, AW157207.1, AW468156.1, AW770787.1, AI266259.1, AA599244.1, AI377803.1, AA527031.1, AI572106.1, AA279430.1, AA72533I.1, AI302964.1, AW379942.1, AI567039.1, AI593485.1, D52427.1, D55742.1, AI956843.1, T10410.1, AA210577.1, C01624.1, AA165991.1, AW214633.1, AI551647.1, AW489266.1, AI467091.1, AA473146.1, D55908.1, AW163183.1, AI606224.1, R98544.1, AA726787.1, W45824.1, AI942680.1, H33984.1, R21996.1, AI632719.1, AI423781.1, AA829983.1, AA030373.1, AL139274.6, AL137180.3, AL160258.3, AL138875.3, AL137000.3, AC027490.3, AL137249.7, AC069145.1, AC018473.10, AC069071.2, AC025451.3, AC010432.4, AC006451.2, AC020695.3, AC021677.3, AC010109.4, AC019599.1, AL135932.4, AL137013.3, AL138725.4, AC012014.5, AC012323.4, AC024272.2, AC044797.2, AC027215.2, AC016350.3, AC027600.1, AC024254.2, AC024026.2, AC016878.3, ACOl 1272.3, AC012369.2, AF188032.1, AL157936.3, AL139418.1, AP001813.1, AP001198.1,

SEQ ID NO. 136

NGO-Br-43

AB023420.1, L12723.1, X67643.1, AF077354.1, NM_008300.1, D85904.1, X67641.1, X67642.1, X67640.1,

ACOl 1013.17, U23921.1, NM_014278.1, AB023421.1, NM_01 1020.1, D49482.1 , ABOO 1926.1, NM_006644.1 , AF039695.1 , AB003334.1 , AB003333.1, D86956.1, Z47807.1, NM_013559.1, L40406.1 , D67017.1, D67016.1,

AB005279.1, AE003433.1, AC010072.5, AC004674.1, AL078621.19, AL096821.2, Z71263.1 , Y13478.1 , AC008545.3, ACOl 1751.2, AC009489.3, AE003820.1, AE003518.1, M96150.1, AC007453.1 , AC006409.2, AC006502.2, AC002350.1, AC003006.1 , ALl 32793.24, AL121904.13, AL135879.1, AL132994.2, AL121790.2, AL133033.1, AJ251914.1, Z73907.1, AL008713.1, AL034348.5, AL034551.14, AL033522.1 , AL008628.1, AP000555.1, AB028948.1, AL135032.1, AW609809.1, AW391888.1, AW609816.1 , AW817219.1, AI567970.1, AW578992.1, AI925201.1 , AW363570.1 ,

AW085727.1, AI1881 18.1, AI560115.1, AI754819.1, AI956648.1, AA493400.1, AW754210.1, AA191559.1, AA173193.1, AW367717.1, AW583074.1, AI907727.1, AI627184.1, AW513086.1, AI952125.1, AW609784.1 , AWl 92860.1, AW489091.1, AW578990.1, AA205597.1 , AI274739.1, AI014766.1, AA913650.1 , A W363562.1, AI230094.1, AI140781.1, AI375447.1, AI983708.1, W74245.1, AW613658.1, AA913187.1, AA633656.1, AA162193.1, AI678576.1, AW817504.1, AA518224.1, AA210820.1 , AW819755.1, AA216635.1, AI866008.1, AA354293.1, AA874242.1 , AA761335.1, AA103602.1, AW545353.1, AA227204.1, AW545094.1, AW537735.1, AA991908.1, AW819997.1, AW578928.1, AW262251.1, AI408846.1, AW542227.1, AA125191.1, AA437859.1, AA821679.1, AW754207.1, AA542289.1, AA121736.1, AA591244.1, AW861588.1, AI909282.1 , N50726.1 , AW582514.1, AI956869.1, AW196018.1, AW609842.1, AW372094.1, AI799801.1, AW817153.1, AW609769.1 , AW582510.1, AW817315.1, AW371571.1, AW817164.1, AW817496.1, AW817372.1, AW582499.1, AW391901.1, AW381775.1, AA870633.1, AA498893.1,

AA687763.1 , AW817440.1, AW371552.1, AW371548.1, Rl 1513.1 , AW817445.1, AI314009.1, AI760838.1, AC020834.2, AC015501.3, AC021286.3, AC022550.1 , AL137142.8, AC048384.2, AC065723.1, AC063302.1 , AC039237.1 , AC034727.1 , AC034094.1, AC025168.3, AC013883.1, AL135795.3, AL160402.2, AL121814.1, AC034304.2, AC021076.3, AC036128.2, AC068226.1, AC025689.3, AC067810.1, AC027184.2, AC017102.5, AC023692.2, AC018288.1 , AL121956.4, AL138965.3,

SEQ ID NO. 137 NGO-Br-43 MK132 T3 5' AB023420.1, L12723.1, X67643.1 , AF077354.1 , NM_008300.1, D85904.1, NM_006644.1, AF039695.1, AB003334.1, AB003333.1 , D86956.1 , NM_014278.1 , NM_011020.1 , U23921.1 , AB023421.1, D49482.1 , ABOO 1926.1 , U81260.1 , AJ132792.1, NM H3559.1, AE003820.1, AE003518.1, AC007453.1, AC006409.2, U76309.1, AL121775.2, AL133033.1, AL034348.5, AL034551.14, AL008628.1, L40406.1, AP000555.1, AB028948.1, D67017.1 , D67016.1, AF245116.1, AC008865.3, AC007171.4, AC006200.2, AC006624.1, NM_013513.1, AE003750.1, AE003571.1, ACOl 1809.2, ACOl 2380.1 , ACOl 1198.2, U78296.2, AF 106589.1 , Y 14213.1 , AL078594.36, Z70757.1 , Z77657.1 , AL049861.18, ALl 15647.1, ALl 13847.1 , ALl 11874.1, U04056.1, U04055.1 , U03487.1, AB005279.1, AB005275.1, U00035.1, M57719.1, L35933.1, X56682.1 , M59962.1, AW578992.1, AW363570.1, AW609809.1, AW391888.1 , AW609816.1, AW817219.1, AW367717.1, AW578990.1, AA191559.1, AW363562.1, AW583074.1, AL135032.1, AW609784.1, AI909282.1 , AI907727.1 , A W754210.1 , AW817504.1 , AA626524.1 , T29047.1 , AA370218.1 , W26511.1, AA755774.1 , AW817215.1, AA125191.1, AW609842.1, AW817153.1, AW609769.1 , AW582510.1 , AW582514.1, AW817164.1, AW817496.1, AW817440.1, AW817372.1 , AW817318.1, AW817315.1, AW817234.1, AW582499.1, AW391901.1, AW381775.1 , AW372094.1, AW371556.1, AW371553.1, AW371550.1, AW817445.1, AW817442.1 , AW601252.1, AW582504.1, AW371571.1, AW371552.1, AW371548.1, AW817364.1 , AW817319.1 , AA543642.1, AA437859.1, AW371570.1, AW817432.1, AW372116.1, AW819755.1, AW371546.1, AW609859.1, AW609807.1, AW371549.1, AW609846.1 , AW578928.1, AW609867.1, AW609856.1, AA518224.1, AW609844.1, AW384296.1 , AI760838.1,

AA870633.1, AAl 17945.1, AI956648.1, AW748834.1, AI827505.1, D29434.1, AA615363.1 , AA445826.1, AJ396671.1, AW819997.1, W22433.1 , AW839103.1, AA874242.1, AW754207.1, AA103602.1, AW125594.1, AA919208.1, AW366794.1, AW371561.1, AI314009.1, R54223.1, AW371568.1, AI567970.1 , AW861588.1, AW229772.1, AA645750.1, AA212025.1, AA821679.1, AV312929.1, AW391883.1, AC020834.2, AL137142.8, AC027421.2, AC025860.2, AC055864.2, AC065723.1, AC063302.1 , AC039237.1, AC034727.1 , AC034094.1, AC022301.6, AC068812.8, AC012157.9, AC034304.2, AC009781.5, AC009321.5, AC023056.7, AC027672.3, AC025689.3, AC027184.2, AC016065.4, AC009899.5, AC010563.3, AC013243.4, AC018288.1, AC015160.1, AC005450.4, AL356425.1, AL356303.2, AL121589.12, AC002417.1, AL139108.2, AP001180.1, SEQ ID NO. 138 NGO-Br-43 MK132/T73'

AB023420.1 , NM_008300.1 , D85904.1 , AF077354.1 , X67643.1 , LI 2723.1 , NM_011020.1 , U23921.1, D49482.1 , AB001926.1 , AC010072.5, Z71263.1, AC009489.3, AC024817.1, AE003641.1 , AE003408.1 , AC012039.10, AC004614.1 , AF164299.1, NM_008229.1, AC006355.3, AF071221.1, AC007172.6, AC005856.1, AC005495.1, AC004671.1, U31758.1, AE001016.1, AL031853.1, AL023804.1, X59603.1, L39125.1, D01021.1, AI567970.1, AI925201.1, AW085727.1, AI188118.1, AI560U5.1, AI754819.1, AA493400.1, AA173193.1, AI627184.1, AW513086.1, AI952125.1, AW192860.1, AA205597.1₎ AI274739.1, AI014766.1, AA913650.1, AI140781.1, AI375447.1, AI983708.1, AW613658.1, AA913187.1, AA633656.1, AI678576.1, AA210820.1, AA216635.1, AI866008.1, AA761335.1, AW545353.1, AA227204.1,

AW754210.1, AW545094.1, AW537735.1, AA991908.1, AW262251.1, AI408846.1, AW542227.1, AW819755.1, AW819997.1, AW861588.1, N50726.1, AI956869.1, AW196018.1, AI799801.1, AW578928.1, AA687763.1, C76500.1, AW529607.1, Rl 1513.1, AW754207.1, R54223.1, AA061925.1, C81619.1, AW604699.1, AI347806.1, AA558925.1, AI593463.1, AA179753.1, AA542420.1, AW682076.1, AU020108.1, W27793.1, C81004.1, AA180330.1, AA121181.1, Z18817.1, AA823019.1, AI911599.1, A W060626.1, R60452.1, AW583074.1, AI197516.1, AA935133.1, AU015665.1,

AA671121.1, AW604696.1, AW366794.1, AI760838.1, N74649.1, AW071627.1, AA408319.1, AA407913.1, AI501198.1, AA799083.1, AA543635.1, AW213908.1, AI576267.1, AV165705.1, AA434598.1, AA703912.1, AW071628.1, AV294079.1, AW754208.1 , N79564.1 , AW371893.1, AA655993.1, R56469.1, AI569348.1, AA948300.1, AI655547.1, AV301839.1, AC048384.2, AC002518.1, ALl 60402.2, AC068975.1, AC026382.3, AC020551.2, AC021393.2, AL353725.3, AL354926.1, AC018920.5, AC046135.4, AC064821.2, AC025511.2, AC026745.3, AC010464.4, AC036128.2, AC021573.4, AC068383.1, AC066588.1, AC027012.2, AC018990.4, AC026061.2, AC021717.3, AC024037.2, AC015653.3, AC019002.3, AC022038.2, AC017901.1, AC006911.1, AL121834.8, AL160290.3, ALl 57819.2, SEQ ID NO.139 NGO-Br-43 MK261/T3 5'

AB023420.1, X67643.1, L12723.1, NM_008300.1, AF077354.1, D85904.1, X67641.1, X67642.1, ACOl 1013.17, U23921.1, NM_014278.1, AB023421.1, NM_011020.1, D49482.1, AB001926.1, AL132776.11, AL078621.19, Y13478.1, ACOl 1751.2, AC009489.3, AC006502.2, AC002350.1, AC003006.1, AL135879.1, AL121790.2, AC007244.2, AC019183.3, AC01O361.3, ACOl 1292.2, AF248484.1, NM_013559.1, AC004459.1, AC003984.1, AC002460.1, AC004612.1, AC004822.1, AC006322.2, AC0O4988.2, AC005050.2, AC008173.2, AC004772.1, AC005406.2, AC006559.6, AC009248.6, AC008071.2, AC007794.1, AFl 01874.2, AF064254.1, AC003689.1, AC003678.1, AF068862.1, AC004075.1, AC004043.1, U01882.1, AL163207.2, Z72001.1, AL160192.2, AL049555.6, AL078595.12, U50871.1, AL035661.16, AL080316.8, AL050334.12, AL109854.10, AL096802.11, Z68873.1, AL031000.1, AL023806.1, Z97987.1, Z98748.1, Z84477.1, AL021307.1, L40406.1, AP001065.1, D67017.1, D67016.1, W74245.1, AA121736.1, AA542289.1, AA591244.1, AA498893.1, AA354293.1, AA162193.1, AI314009.1, AW489091.1, N85657.1, AI956648.1, AI230094.1, R56974.1, AW861596.1, AV226442.1, AV226379.1, AA063966.1, AA821679.1, AA896038.1, AL135032.1, AA874242.1, AW578931.1, AW578926.1, AA103602.1, AA518224.1, AA499765.1, AA385978.1, AV320109.1, AA121221.1, AV226463.1, H93522.1, AA247166.1, W20649.1, AI956324.1, AW385268.1, AW385266.1, AJ396671.1, AW502280.1, AW501910.1, AW501774.1, AW274501.1, AU037061.1, AI085867.1, AA747312.1, AA102000.1, H23069.1, H10565.1, AC020834.2, AC015501.3, AC021286.3, AL355143.4, AC025168.3, AC016767.3, AL353608.2, AL135795.3, AC036128.2, AC010814.5, AC017022.3, AC022968.2, AC022760.2, AC009875.2, AL353625.2, AL121956.4, AP001587.1, AC021053.7, AC018474.9, AC034305.2, AC068992.3, AC040969.2, AC040965.2, AC040960.2, AC023410.3, AC023538.2, AC026698.3, AC025182.2, AC024569.2, AC022433.3, AC022430.3, AC022135.3, AC008773.6, AC008968.4, AC010234.3, ACOl 1346.3, AC008673.6, AC021595.3, AC062017.2, AC023116.4, AC010133.2, AC058804.1, AC018978.5, AC040961.1, AC026493.3, AC021464.2, AC023858.2, AC021948.3, AC018443.5, AC016763.5, AC021208.3, AC015823.3, AC022039.2, AC023560.2, AC009666.4, AC024010.2, AC010895.3, AC012669.2, AC021319.1, AC012502.2, AC013259.1, AL139375.7, AL355345.2, AL139803.7, AL136087.6, AL158147.4, AL354875.3, AL138702.5, AL353151.2, AL162492.3, AL034378.2, AP001986.1, APOO 1828.1,

SEQ ID NO.140 NGO-Br-43 MK2912/T3 5'

AB023420.1, X67643.1, L12723.1, AF077354.1, NM_008300.1, D85904.1, X67641.1, X67640.1, ACOl 1013.17, X67642.1, U23921.1, NM_014278.1, AB023421.1, NM_011020.1, D49482.1, AB001926.1, AL078621.19, AL096821.2, Y13478.1 , NM_006644.1 , AC004003.1 , AF039695.1 , AFl 17829.1 , AF069291.1 , AC002350.1 , AB003334.1 , AB003333.1 , D86956.1, L43098.1, L43082.1, AC010352.4, AC007730.2, AC007662.2, AF240629.1, AF123535.1, AC002124.1, AF130247.2, AC005228.1, AC009248.6, AF081491.1, AF081490.1, AF081489.1, AF081488.1, AF081487.1, AF165138.1, AF064254.1, AFl 12117.1, U96409.1, AC005900.1, AC004636.1, AC004472.1, U69258.1, AL163224.2, AL163206.2, AL161537.2, X15901.1, Y08502.1, Z68873.1, AL022727.1, AL022097.1, AL031073.1, AL035528.2, AP001679.1, AP000957.2, AW489091.1, AI230094.1 , AI956324.1 , AI956249.1, AA591244.1, AI316935.1, AW069322.1, AA498893.1, AW318627.1, AI506418.1, AA542289.1, AA840049.1, AA205624.1, AI314009.1, AA499765.1, AV320109.1, W74245.1, AA726333.1 , AA408320.1 , AA247166.1 , AW755799.1 , AW755396.1 , AW568012.1 , AW567990.1 , AW397511.1, AW234798.1, AA162193.1, AW681906.1, AL045611.2, AI851924.1, AL044212.1, AL043449.1, AA793473.1, AA690112.1, AA675583.1, AA360776.1, AA183406.1, AA120371.1, AV131040.1, AV047607.2, AV047086.2, AI046570.1, AA499782.1, AA498000.1, AA144603.1, AA139245.1, AA138950.1, AAl 10497.1, AA062258.1, AA060083.1, H23069.1, H10565.1, R59827.1, R28864.1, AC020834.2, AC015501.3, AC021286.3, AC022550.1, AC022089.4, AC010428.4, ACOl 1403.2, AC025168.3, AC021755.4, AC016767.3, AL163541.6, AL353608.2, AL135795.3, AL163545.4, AL160031.4, AC026084.2, AC026562.3, AC051613.3, AC008483.4, AC046137.3, AC068226.1, AC016002.5, AC031979.1, AC015578.4, AC019235.2, AC019228.4, AC017102.5, AC008519.2, AC016281.2, AL356272.1, AL139823.2, AL137142.8, AL353625.2, AL121956.4, AL138965.3, AL136456.3,

SEQ ID NO. 141

NGO-Br-43

MK466/T3 5'

AB023420.1, X67643.1, L12723.1, AF077354.1, NM_008300.1, D85904.1, X67641.1 , X67642.1, X67640.1 , ACOl 1013.17, U23921.1 , NM_014278.1, AB023421.1, NM_01 1020.1, D49482.1, AB001926.1, AL078621.19, AL096821.2, Y13478.1, AL121904.13, AJ251914.1, AC010352.4, AC007662.2, NM_013559.1, AE003537.1, AC004492.1, AC009248.6, AC007388.3, AF064254.1, U96409.1, AC004636.1, ALl 21821.5, ALl 61537.2, Z48006.1, Z68873.1 , AL022097.1, AL035528.2, L40406.1 , M26221.1 , D67017.1, D67016.1, AW489091.1, AI230094.1, AA591244.1, AA498893.1, W74245.1, AA542289.1, AI314009.1 , AI956324.1, AA121736.1, AI956249.1, AI316935.1, AA162193.1, N85657.1 , AW069322.1, AI506418.1, AV226442.1, AI956648.1, AA499765.1, AA354293.1, AV320109.1, AW318627.1 , AA205624.1 , AA063966.1 , R56974.1 , AV226379.1 , AA247166.1 , AA840049.1 , AW385268.1 , AW385266.1, AA726333.1, AV340213.1, AI870749.1, AV047607.2, AV047086.2, AI046570.1, AA747312.1, C39670.1, AA499782.1, AA498000.1 , AA144603.1, AA139245.1, AA138950.1, AAl 10497.1, AA062258.1, AA060083.1, H23069.1, H10565.1 , R59827.1, AC020834.2, AC015501.3, AC021286.3, AC025168.3, AC021755.4, AC016767.3, AL163541.6, AL353608.2, AL135795.3, AL163545.4, AL160031.4, AC026084.2, AC026562.3, AC064862.2, AC016002.5, AC019235.2, AC017102.5, AL353625.2, AL121956.4,

SEQ ID NO. 142 NGO-Br-43 MK691/T3 5'

AB023420.1, X67643.1, L12723.1, NM_008300.1, D85904.1, AF077354.1 , X67642.1, NM_014278.1, AB023421.1, NM_011020.1, U23921.1, D49482.1 , ABOO 1926.1, NM_006644.1, AF039695.1, AB003334.1, AB003333.1, D86956.1, AE003433.1, AC004674.1 , AC008545.3, ACOl 1751.2, AC009489.3, NM_013559.1, AC006502.2, AC003006.1, AL132793.24, AL135879.1, AL121790.2, AL008713.1, L40406.1, Z47807.1, M38250.1, D67017.1, D67016.1 , AC010879.2, AC012082.6, AC020943.5, AC006200.2, AF248484.1, AC009311.2, AC004459.1, AC004745.1, AC003984.1, AC002452.1 , AC002461.1, AC004612.1, AC004741.1, AC004930.1 , AC002519.1 , AC008173.2, AC005406.2, AC006559.6, AC003666.1, AF101874.2, AC003689.1, AC003678.1, AC005393.1, AC004075.1, AC004043.1, U01882.1, U80460.1, AL160192.2, AL049555.6, AL035665.29, AL078595.12, U50871.1, AL050334.12, AL096802.11 , Z97987.1 , Z92844.1 , Z98748.1 , Z84475.1 , AL009176.1 , U41995.1, AB005275.1 , Yl 5994.1 , ABOl 6880.1 , AB020870.1 , AI956648.1, AA354293.1, ALl 35032.1, AA162193.1, W74245.1, AA821679.1, AA121736.1, AA103602.1, AA874242.1, AA518224.1, AI907727.1, AA121221.1, AW861596.1, N85657.1, AA542289.1, AW582514.1, AW372094.1, AW817315.1, AW371571.1 , R56974.1, AW817219.1, AW817496.1, AW817372.1, AW817364.1, AW817164.1, AW817153.1, AW609859.1, AW609846.1, AW609816.1, AW609809.1 , AW609769.1, AW582510.1, AW582499.1, AW391901.1, AW381775.1 , AW371552.1 , AW371546.1, AA437859.1, AW609842.1, AW371550.1, AW817440.1, AW817432.1, AW817319.1, AW609867.1, AW609856.1, AW391888.1, AW384296.1, AW371549.1, AW371548.1, AW817445.1, AW817442.1, AW609844.1 , AW371570.1, AW817504.1 , AW371556.1 , AW817234.1 , AW371553.1 , AW817318.1, AA870633.1 , AA125191.1, AW609784.1, AW582504.1, AW372095.1, AA191559.1, W20649.1, AW601252.1, AA896038.1, AI314009.1, AA543642.1, AW3721 16.1 , AA498893.1 , AV226442.1, AW578931.1, AV226379.1, AW578926.1, AA063966.1, AA385978.1, AJ396671.1, AW371561.1, AI827505.1, D29434.1, AW748834.1, AA591244.1, AW371568.1, W26511.1, AW229772.1, H93522.1 , AV226463.1 , AA549649.1, AW577563.1, AL042714.2, AI656127.1, AI633338.1, AI267631.1 , AI203278.1, AA714219.1, AA580845.1, AA311379.1, AW210124.1, X85639.1, AC020834.2, AC021286.3, AL137142.8, AC013883.1, AL133489.1, AL121814.1, AC069108.1, AC068732.1, AC021076.3, AC067810.1, AC010814.5, AC023692.2, AC009875.2, AP001587.1, AP001180.1, AC034305.2, AC068992.3, AC040960.2, AC026998.2, AC044809.2, AC023410.3, AC025752.4, AC022433.3, AC022430.3, AC022135.3, AC008961.4, AC008968.4, ACOl 1346.3, AC008561.3, AC008539.3, AC021595.3, AC017100.3, AC010133.2, AC010810.3, AC009657.3, AC026824.2, AC027281.2, AC021548.3, ACOl 1954.5, AC023858.2, AC015681.4, AC02541 1.2, AC021948.3, AC013321.4, AC025218.2, AC013368.4, ACOl 1055.6, AC017082.3, AC015943.3, AC021208.3, AC015823.3, AC016421.4, AC013297.4, AC022039.2, AC023560.2, AC023034.2, AC025599.1, AC012451.3, AC021350.2, AC021319.1, AC007799.4, AC013759.2, ACOl 1107.2, AC007914.1, AL355345.2, AL160407.4, AL157785.2, AL139344.4, AL355599.2, AL355332.1, AL353143.2, AL161913.2, AL353624.1, AL158819.2, AL133255.9, AL157759.2, AL158140.2, AL034378.2, AP001488.1, AP001336.1,

SEQ ID NO.143 NGO-Br-44 MK062/T3 5'

AF210818.1 , AF 134894.1 , ABOl 4540.1 , NM_009302.1 , AF053974.1 , AE003678.1 , AE003692.1 , AC004260.1 , AC005244.1, AL162633.2, AL138996.2, AL049522.1, AL035603.11, AE003589.1, AE002906.1, AC006926.1 , AC002080.1, U91322.1, AC006043.1, AC005082.2, AF128252.1, AF128251.1, AFl 28249.1 , AFl 28247.1, AC005548.1, AC005269.1, U32723.1, AL022598.2, AL133391.5, AL121656.2, Z35601.1, AL034561.4, AL033530.1, U35657.1, K0171 1.1 , AB027827.1, AB027454.1 , M20865.1, J04355.1, Z66517.1 , AI181303.1, AW824953.1, AW123265.1, AW504308.1 , AW824368.1 , AW425515.1 , AJ392422.1 , A W202793.1 , AW029904.1 , AW487421.1, AV070180.1 , AU013359.1, AC025788.2, AC026250.3, ACOl 1979.3, AC026628.2, AC009800.6, AC023126.2, AC014216.1, AC009539.5, AL160255.5, AL138790.2, AC055752.5, AC055875.2, AC053484.3, AC021515.3, AC024494.1 , AC021857.2, AC010097.4, AC016475.1, AC012199.4, AC013013.1, AL031726.16, AL133259.23, AL355073.1, AL353152.2, AL137183.1, AP001852.1, AC024905.7, AC024890.7, AC008713.5, ACOl 1376.2, AC008856.4, AC026958.2, AC024595.2, AC026259.3, AC025966.2, AC025818.2, AC022735.3, AC024387.2, AC022040.2, AC023375.2, AC017402.1, AC009610.1, AL356358.1, AL355293.2, AL008872.1, SEQ ID N0.144 NGO-Br-44 MK062/T7 3'

AB014540.1, AF134894.1, AC004834.2, AC006538.1 , Z97054.1, AFl 11168.2, AL109914.16, AL121586.28, AC002094.1, AC006457.3, AL031985.10, AC002400.1 , U80017.1 , AF030453.1 , AL031846.2, Z95152.1 , AC005031.1, AL049874.3, Z72006.1, AC007386.3, AC000353.27, AC005207.1, AC003002.1, AL160191.2, AL034429.1, AC004552.1, AC004195.1, AL078639.5, AF 168787.1 , AC002477.1, AC005796.1, AC005500.2, AP000689.1, AC005081.2, AC002492.1, AC004815.2, AC005049.2, AC006064.9, AC005839.1, AC002350.1, AL163292.2, AP001747.1 , AC005412.5, AC003104.1, AL049569.13, AP000505.1, AP000045.1 , ACOl 1890.4, AC007225.2, AC005102.1, AL136295.2, Z85994.1, AL050321.8, AC005227.2, AC003663.1, AC008115.3, ACOl 1311.11, AC005793.1, AL024507.7, AL096800.20, AL049795.20, AW467233.1, AA186857.1, AW572140.1, AW473996.1, AW327624.1, AI889579.1, AI049630.1,

H68343.1, AW850230.1, AI733856.1, AAl 35761.1, AA583386.1, AW873261.1, AW833047.1, AI754421.1, AA838091.1, AA468923.1, AA176605.1, AW157005.1, AI452836.1, AI090377.1, AA152253.1, AI474127.1, Al 192465.1 , AI064786.1, AA721645.1, AI799569.1, AI283938.1, H47736.1, AW798093.1, AI340151.1, AA992126.1, AI762528.1, AI309943.1, AW769687.1 , AW089625.1, AW008184.1 , AA857812.1, AW167202.1, AA630854.1, AA298365.1, AI310343.1, AW589345.1, AI859906.1, AI249365.1, AA302978.1, AW674631.1 , AW516080.1, AW243808.1, AW069227.1,

AI634187.1, AI457313.1, AI431513.1, AW242031.1, AW328331.1, AL038936.1, AI446336.1, AA827383.1, AA502991.1, AA487569.1, AA130647.1, AW574899.1, AI815210.1, AI696878.1, AA642809.1 , AA176257.1, AI336771.1, AI285493.1, AI797998.1, AI653515.1, AA612727.1, AA218631.1, AI791659.1, AI278972.1, H57439.1, AI065038.1, N38991.1 , AA601218.1, AI362442.1, AI06671 1.1, AA832175.1, AI653776.1 , AA604149.1 , AI446623.1, AA877992.1, AW082104.1, AI962030.1 , F29968.1 , AI049845.1 , AA287570.1 , AA284247.1 , AW852684.1 , AA633981.1, AA443390.1 , AI633294.1 , AA594220.1, AA429197.1, AA429020.1, AA290878.1, AA569648.1, AC026250.3, AL356218.1, AC018751.22, AL159970.7, AC027272.2, AC008630.3, AL136222.3, AC008616.3, AC019157.4, AL161671.5, AC012306.3, AC023232.3, AC015795.3, AL135839.3, AC019268.3, AL355001.3, ACOl 1771.3, AC013355.3, AC012652.3, AL158828.4, AC044797.2, AL158039.2, AF235092.1, AC024561.3, AC008379.5, AC009149.4, AL354720.3, AC027472.2, AL137849.2, AC009041.5, ACOl 1423.1, AL355076.1, AC020922.5, ACOl 1895.3, AC026051.3, AL161911.3, AC021016.3, AC025395.2, AC008026.2, AC008745.4, AC015920.4, AL138762.5, AP001462.1, ACOl 1488.5, ACOl 8557.4,

SEQ ID NO.145 NGO-Br-45 MK506/T3 5'

AC005080.2, AC004883.2, AF015553.1, AF038969.1, AF038968.1, AF038967.1, AF035737.1, AF036613.1, NM_010365.1, AF017085.1, AC002448.1, AC004637.1, AF133093.1, AC007681.3, AC007138.1, AL161493.2, AL009179.1, AW513878.1, AW440589.1, AW303749.1, AW172719.1 , AW150741.1, AI942459.1 , AI926534.1, AI890828.1 , AI799542.1 , AI755197.1 , AI669472.1 , AI569466.1 , AI422057.1 , AI366702.1 , AI359749.1 , AI359734.1 , AI342520.1, AI341684.1, AI339415.1, AI334035.1, AI301890.1, AI268293.1, AI189650.1, AI016018.1, AI890844.1, AW503621.1, AW131511.1, AI862016.1, AI832845.1, AI564518.1, AI361033.1, AI356100.1, AWl 17790.1, AI961455.1, AI708465.1, AI359726.1, AI934639.1, W44732.1, AW157829.1, AA075629.1 , AW504960.1, AI829529.1 , AA527778.1, AW069097.1, AI653807.1, AWl 50934.1, AI338067.1, AA412018.1, N26570.1, AI762723.1, AA843358.1, AI633291.1, AA639747.1, AI523792.1 , AA758117.1, AA156353.1 , N261 16.1, AA81 1496.1, W80780.1, AI613456.1 , AI559431.1, AW189020.1, AI305239.1, AI762958.1, N51844.1, N31942.1, AI491778.1, AAl 13854.1 , AI270445.1, AA662713.1, AA732559.1, AI2901 17.1, AA641906.1, AA632756.1, AI829267.1 , AA535035.1 , AA612924.1, AI880822.1, N90508.1, AI924215.1 , AI689619.1 , AA441894.1 , AW090502.1, AA581632.1, N58502.1, AI735656.1, AW129208.1, AI750591.1 , F21287.1, AA722095.1, AI538729.1, T03439.1, AI040879.1 , H68263.1, AI699888.1, AI653613.1, AA720545.1, AW503247.1, AI630929.1, AI582862.1, AC004166.10, AC061712.2, AC006995.2, AC005098.1, AC068263.1 , AC027219.1, AC018360.8, AC068475.1, AC013548.2, AC012587.4, AC018360.7, AC046131.3, AC023050.12, AC020741.3, AC026529.2, AC021802.3, AC025847.2, AC026086.2, AC026241.1, AC007400.2, AC009235.2, AL353134.2, AL162251.3, AP001983.1, AP000710.1, AP000643.1, SEQ ID NO.146 NGO-Br-46 MK283 T3 5'

NM_016374.1, AB030181.1, AF245512.1 , AF208045.1, AF2141 14.1, AF227899.1 , NM_002892.1 , AL031777.2, S66427.1, AB033596.1, NC_001 136.2, AE00351 1.1, AC009322.1, AC007229.1, U80436.1, L771 19.1, AC004440.1, AL121985.13, AB026643.1, J03902.1, AC007188.6, AC002461.1, AP000457.3, AB005240.1 , AA485189.1 , R20183.1, AW431383.1 , F06553.1, AW431576.1, AI153796.1, AV249408.1 , AL079586.1, AV295325.1, AV296868.1, AV304343.1, AV335031.1. AV251 198.1, AA713956.1 , AV323916.1 , AV351047.1, R14337.1, AW242991.1 , AA296993.1, AV318231.1, AV298138.1 , AW820697.1 , AV407971.1, AV407307.1, AW611599.1, AW571035.1 , AW570959.1, AW570812.1, AW163609.1, AW162962.1, AI506067.1, T86264.1, AW775546.1, AV439780.1, AW696915.1, AW693997.1,

AW690655.1, AW589802.1 , AW470688.1, AW255547.1 , AW243044.1, AW195535.1, AW135177.1, AI912938.1, AI823378.1, AI816820.1, AI809563.1, AI803416.1, AV146241.1, AI770033.1, AI766212.1, AI766190.1, AI632787.1, AI478418.1, AI280988.1, AI246187.1, AI242863.1, AI160538.1, AI143611.1, AI091619.1, AI055903.1, AI034050.1, AI032880.1, AI015057.1, AA988532.1, AA922855.1, AA863243.1, AA81 1866.1, AA731602.1, AA524142.1, AA375259.1, AA001674.1, W80645.1, W56179.1, W39715.1 , W32984.1, W31210.1, R40471.1, AA524073.1, AL353899.3, AL133418.3, AL161423.4, AC010092.3, AL136366.4, AL049185.4, AC021804.3, AC005140.6, AC004153.5, AC022648.1, AC017725.1, AF181450.1, AC006858.1, AL157786.2, AC06481 1.2, AC027723.2, AF254982.1, AC025820.3, AC027691.1, AC018982.1, AL354653.2, AL049180.3, SEQ ID NO. 147 NGO-Br-46 MK283/T73'

AF083249.1, AL133010.1, AF227899.1, AF2141 14.1, AF208045.1, NM_016374.1, AB030181.1, AF245512.1 , AE003519.1, U14635.1, NC_001147.1, NM_012269.1, AC002454.1, AC012463.3, AC006029.2, AE001314.1, AF009010.1, AF039906.1, AL163262.2, Z97055.1, AL031429.11, AL096773.6, Z75151.1, AP001717.1, AP000189.1,

AP000045.1, AP000300.1, AP000113.1, AI091806.1, AW450239.1, AI632699.1, AI130893.1, AI017851.1, AA279595.1, AA082926.1, AI474175.1, AA169631.1, AI136605.1, AW534954.1 , AW047204.1 , AA669471.1, AW050083.1, AA249450.1, AI138109.1, AI138113.1 , AA248905.1, AW641956.1, AW402551.1, AU079907.1, AI817621.1, AV071325.1, AI472756.1, AA586216.1, AA347968.1, AA273379.1, H84029.1, H57875.1, R90945.1 , H17170.1, AL133418.3, AL353899.3, AC015441.1, AC067880.1 , AC007990.2,

SEQ ID NO. 148 NGO-Br-46 MK482/T3 5' NM_016374.1, AB030181.1, AF227899.1, AF208045.1, AF214114.1, AF245512.1, AF083249.1, AC027657.1, S57162.1, S57160.1, S57153.1, AC006420.3, U23522.2, NM_002892.1, AC007032.2, AC004440.1, S66427.1, Z48784.1, AC002461.1, AC005207.1, AC004048.1 , AL031595.4, AP001819.1, AA485189.1, R20183.1 , AL079586.1, AW431383.1, F06553.1 , AW431576.1, AW242991.1, AA296993.1, AI153796.1, AV249408.1, AV295325.1, AV296868.1, AV304343.1, AV335031.1. AV251198.1, AV323916.1, AA713956.1, AV351047.1, AV318231.1, AA743290.1, AW496257.1, AV298138.1, AW820697.1 , AW611599.1, AW571035.1, AW570959.1, AW570812.1, AW162962.1 , H34667.1, T86264.1, AW754057.1, AV439780.1, AW696915.1, AW693997.1, AW690655.1, AW341096.1, AW270194.1, AW207299.1, AV318321.1, AW057255.1, AW043594.1 , AV146241.1, AI698675.1, AI698047.1 , AI570113.1 , AI506941.1, AI393132.1, AI361113.1, AI246187.1, AI222232.1, AA962426.1, AA926638.1, AA837710.1, AA829497.1, C68432.1, C57364.1, AA370189.1, C10349.1, W88641.1 , N73528.1, H69420.1 , H50563.1, H24328.1, H24314.1, H23256.1, F02811.1, Cl 1969.1, AL133418.3, AL353899.3, ACOl 1267.2, AL136366.4, AC020604.4, AC068607.1, AC008570.3, AC021804.3, AC022944.2, AC022648.1, AC017725.1, AL121987.2, AC064811.2, AC021183.2, AC027723.2, AC026384.2, AF254982.1, AC027412.2, AC009881.3, AC013653.2, AC018982.1, AL034557.7, AL049180.3,

SEQ ID NO.149 NGO-Br-46 MK482/T7 3'

NM H6374.1, AB030181.1, AF208045.1 , AF227899.1, AF214114.1, AF083249.1, AF245512.1, NC .001137.2, U18916.2, AC007032.2, L771 19.1, AC005687.1, AP001073.1, AP000969.1, AC002038.1, AC007882.3, AC007188.6, AC009230.3, AC007379.2, AE003827.1, AE003758.1, AE003644.1, AE003410.1, AC002041.1, AC004161.1, AC018359.6, AC004827.1, AC004890.2, AC004896.1, AC009322.1, AC006352.3, AC006359.3, AC004671.1, U40947.1, AC005207.1, U00176.1, U67526.1, AL355921.1 , AF004387.1, AL080287.1, AL050333.18, AL117353.6, AL034563.1, AL132769.1, U66528.1, Y00354.1 , U33010.1, U33008.1, M18061.1, AP000391.1, AP000543.1, J05080.1, AL079586.1, AW242991.1, AA296993.1, AA743290.1 , AA485189.1, AW496257.1, R20183.1, AI153796.1 , AV318231.1, T61718.1, F06553.1, AV295325.1, AV249408.1, AV304343.1, AV296868.1, AV251198.1, AV335031.1, AV323916.1, AW431383.1, AW875017.1 , AW875016.1, AW571035.1, AW570959.1, AW570812.1, T86264.1, AW696915.1, AW693997.1, AW690655.1, AW773470.1, AV439780.1 , AW472410.1, AV351047.1, AW056097.1, AW021051.1, AI963428.1, AI741526.1, C93293.1 , AA668233.1, C23844.1, W36281.1, T14884.1, AL133418.3, AC010092.3, AC019046.3, AC007990.2, AC023145.4, AC016789.4, ACOl 1267.2, AL136366.4, AC017057.5, AC068607.1, AC008570.3, AC068444.1, AC068256.1, AC067904.1, AC021804.3, AC023200.2, AC016697.2, AP000742.1, AC019071.3, AC064811.2, AC068761.2, AC026273.5, AC021183.2, AC068541.2, AC026740.3, AC008480.3, AC027723.2, AF254982.1, AC010791.2, AC026897.2, AC016108.3, AC025610.2, AC024972.2, AC019110.3, AC024025.3, AC024315.2, AC007908.2, AC023202.2, AC023576.1, AC009209.5, ACOl 0683.3, ACOl 1231.3, AC009981.5, AC021671.1 , AC009982.6, AC017924.1, AC014837.1, AL356288.1, AL034557.7, AP001017.2, AP001007.1 , AP001 109.1, SEQ ID NO.150 NGO-Br-46 M 712/T3 5' NM_016374.1, AB030181.1, AF245512.1 , AF178849.1, Y17968.1, AC004537.1, ALl 18523.15, AK000096.1,

AL021396.5, ALl 18494.1, S51239.1, AB032988.1, NM_008671.1, NM_008665.1 , NM_001978.1, AF004294.1, U28389.1 , U28734.1 , X92352.1 , LI 9713.1 , AC002039.1 , AF222800.1 , S79939.1 , D86076.1 , Z46939.1 , D83650.1. D31729.1 , NM_008253.1, NM_003449.1, AC004186.1, U59897.1, AF022465.1, U09825.1, U17837.1, AC007844.32, NM_005381.1, AF132047.1, AC006289.1, AE001393.1, AC004659.1, AF030001.1 , AL035527.1, X86100.1, U15800.1, AB010266.1, L04162.1, AK001314.1, AK000250.1, AK000221.1 , AB015639.1, AB020693.1, AP000344.1, L08135.1, L22219.1, NM_003204.1, AC007870.3, D37887.1, X84060.1, L14750.1, L24123.1 , X77366.1, U08853.1, NM_010238.1, AF069772.1, AC006925.6, AF045462.1, AF017349.1, AL121754.18, AL132977.1, AL009226.1, U14731.1, D89801.1, ABOl 1480.1, D84418.1, NM_015866.1, NM_014977.1, NM_012749.1, AF124726.1 , AF133520.1 , AF019611.1 , U17838.1. AL163217.2, U89340.1, U19361.1, AP001672.1, U12825.1, D45132.1, AB014570.1, AC018721.1, NM_008252.1 , AC002302.1, AF085279.1, AC006070.1, U46900.1, Z83117.1, Z46757.1, M15825.1, AW431576.1, AA485189.1, AW431383.1, W84569.1, W67770.1, AA262427.1, R20183.1, AW369401.1, F06553.1 , AI036486.1 , AV340693.1, AV249408.1 , AV295325.1, AI153796.1, AV296868.1, AV304343.1, AV335031.1, AA713956.1, AV251198.1, R14337.1, AV323916.1, AV351047.1, Al 102488.1 , AJ397247.1, AW158536.1, AA960471.1 , AL079721.1, AU060883.1, F08518.1, M79841.1, AW281090.1, AI573315.1, AV407435.1, AW561908.1, AW099610.1, AI931397.1, AI505223.1, AI159593.1 , AA939911.1, AA838901.1, AA413260.1, D22328.1 , AI044390.1 , AW366844.1, AI908284.1, H33616.1, R54825.1, AW531362.1, AWl 62962.1 , AI746770.1, AI579779.1, AI579345.1, AI575698.1, AI558058.1, AI408526.1, AI408307.1, AW681502.1, AW398648.1, AU061751.1, AU060420.1, AU053145.1, AU053100.1, AA685125.1, AW682367.1 , A W681399.1, AW681336.1, AW619893.1, AW553956.1, AW553928.1, AW550476.1, AW549664.1, AW548257.1, AW547813.1, AW546306.1, AW545571.1 , AW545015.1, AW543191.1, AW542602.1 , AW541865.1, AW536650.1 , AW536323.1, AW320463.1, AW320328.1, AVI 1 1 141.1, AV071436.1, AI376890.1, AI183692.1, AI182809.1, AU015986.1, C85885.1 , C85603.1, AA795177.1, AA636994.1, C80539.1, AA607084.1 , AA606813.1, AA590440.1, AA420329.1, T52646.1, AL353899.3, AC040981.1, AC012588.5, AC023288.6, AC018745.2, AC068493.3, AC053536.2, AC025669.2, AC026017.2, AC026462.1, AC006279.6, AC007340.3, AC024173.1, AC020757.2, ACOl 6876.1 , AC005136.1, AL163051.1, AC026581.1, AC024111.6, AC002317.1, AL136382.3, AL136998.12, AL355576.1, AL355366.1, AL158172.1, AC026532.2, AC034245.2, AC016569.3, AC068147.1, AC027275.1, AC021768.3, AC016171.4, AL121953.13, AL049796.27, AL133375.3, AP000448.1, AC068909.3, AC012055.6, AC034126.2, AC044806.1, AC019128.3, AC020879.2, AC017104.3, AC021627.2, AC020632.4, AC041041.2, AC021 142.4, AC026163.2, AC015535.4, AC016989.4, AC020988.3, AC024625.1, AC015901.3, AL356459.1, AL157895.1, AP001488.1, AP001024.1, AC016142.6, AC020940.4, AC019028.3, AC009717.4, AC023364.3, AC013334.6, AC022565.3, AC020509.1, AC017725.1 , AC004123.1, AC005861.2, AL354874.1,

AL034557.7, AC009361.17, AC015891.10, AC063968.1, AC027650.2, AC025364.2, AC012296.3, AC022310.2, AC023571.2, AC023284.1, AC009962.3, AC021444.1, AL035477.5,

SEQ ID NO.151 NGO-Br-47 MK265/T3 5'

NM_004987.1, U09284.1, AK000906.1, AE003678.1, AF078907.1 , AF035583.1, U41021.1, AE003528.1, NM_000888.1, AL137129.2, AL050403.13, Z69648.1, M35198.1, AC007380.3, AE003454.1, NM_008407.1, AC004300.1 , AE000795.1 , Z71186.1, X70393.1, Z99123.1 , Z80360.1, X95584.1, AW504514.1, AI327306.1, AA299595.1 , AA289280.1 , AI862555.1, AI609736.1, AA968535.1, AI608376.1 , AA037783.1, AI948956.1, AI956192.1, AA201027.1, AI152133.1, AI195455.1 ,

AI089674.1 , AA198689.1 , AA732465.1, AA766629.1, AA989985.1, H58225.1, AA970328.1, AW787078.1 , AW787072.1, AI450546.1, AA799637.1, AW742584.1, AA510363.1, AA450826.1, AA504265.1, AAl 10054.1 , AI854549.1, All 95654.1, AI986356.1, AI943339.1, AW142146.1 , AA102210.1, AI593658.1, Z42656.1, AI722835.1, AI353353.1, H58562.1, AW493431.1, AI237400.1, AA848258.1, AA636357.1, AA220130.1, AW347458.1, AI464258.1, AI408319.1 , AW481822.1, AW417049.1, AW312785.1, AW140389.1, AAl 19018.1, R58438.1, AJ398975.1 , AW017114.1,

AI386040.1, AA066359.1, AI981121.1, AI262403.1, AA646588.1, AA358612.1, AJ392355.1, AA064613.1, AI986343.1, AA511616.1 , AW140647.1 , AI929976.1, AV203690.1, AV198544.1, AV194653.1, AV194457.1, AVI 87669.1 , C48705.1, C48492.1, C48145.1, C45906.1, C41445.1, AA471768.1, D76144.1, AW216171.1, AA269965.1, AA069994.1, AA016593.1, T73549.1, AC010095.3, ACOl 1919.3, AC013271.1, ACOl 1922.2, AC010976.4, AC027815.1, AC012487.3, AC014215.1, AC016057.3, AC016797.3, AC022102.3, AC016575.6, AC021017.3, AC020993.3, AC013658.3, AC024522.1 , AC010066.5, AC014423. I, AL136985.1, AC026261.3, AC027627.3, AC008864.4, AC008740.3, AC037456.4, AC025781.5, AC025706.3, AC024453.2, AC018914.3, AC021788.2, AC023463.2, AC019902.1, AL022281.20. Z98874.1, SEQ ID NO.152 NGO-Br-48 MK124/T3 5'

AJ251245.1, AC004890.2, NM_009477.1, D44464.1 , AC007371.16, AL034423.18, AL096761.1 , AE003806.1 , AF022713.2, AF133262.1, AF133263.1, U69607.1, AC004287.1, U65480.1, AF007190.1, AL035420.15, AW630547.1, AI769091.1, T58810.1, AA403044.1, AW436458.1, AI713670.1, AI712879.1, AI060054.1, AI412971.1, AI010977.1, AW318411.1, AW012719.1, AA817712.1, AA943539.1, AA404342.1, AW121356.1, AI837465.1, AI823387.1, AI877170.1, ALl 18479.1, AI325217.1, AA023318.1, AA020155.1, W34889.1, AI099015.1, W08125.1. R51103.1, AW820705.1, AA475225.1, AA411125.1, AA171085.1, AL160054.4, AC021561.3, AP001490.1, AC027461.1, AC027462.2, AC023571.2, AL355353.3, AC018714.3, AC016883.3, AC022244.2, AC027559.1, AC018671.5, AC016402.1, AL353782.3, AL161937.5, AL022335.6, APOO 1000.1, AC021874.12, AC021023.4, AC018352.8, AC018656.5, AC012674.7, AC022504.9, AC055882.3, AC018752.3, AC010396.3, AC008596.3, AC013747.5, AC068557.1, AC034137.2, AC024948.2, AC007944.2, AC022830.2, AC024504.2, ACOl 1635.3, ACOl 2378.5, AC021874.i l, AC016346.2, AC021250.2, AC018352.7, AC020957.1, AC017056.3, AC020077.1, AC016510.1, AC012123.1, AL356217.2, AL122125.1, AL031301.1, AP001888.1, AP001123.1, AP000850.1,

SEQ ID NO.153 NGO-Br-48 MK124/T7 3' AJ251245.1, NM_006703.1, AF062530.1 , AF062529.1 , ALl 17352.12, AJ249395.1, Z98036.1, AC010305.3, AC006474.3, AC002098.1, AC000396.1, AL078603.4, Z66560.2, M20162.1, AE003687.1, AE003539.1, AE003452.1, AC005005.1, AC004466.1, AC005268.1, AF015725.1, AL163300.2, AL163268.2, Z73972.1, Z99714.2, Z83001.1, Z97200.1, AJ011930.1, AP001068.1, AB012242.1, AB008267.1, AJ229042.1, Z48305.1, X14710.1, AI270576.1, AA349855.1, H60027.1, AA639612.1, R25924.1, AW392280.1, AW450452.1, AI014725.1, AA092495.1, W58640.1, AW022648.1, AI179962.1, AW431718.1, N55875.1, AI178673.1, AW427283.1, R14767.1, AI179961.1_> AW868962.1, D21042.1,

AW062717.1, AW062693.1, AI654799.1, AI652271.1, AI493530.1, AI435022.1, AI289025.1, AI126256.1, AI086076.1, AI032793.1, AA838460.1, AA781029.1, AA643067.1, AA629918.1, AA594551.1, AA573873.1, AA505932.1, AA479474.1, AA447455.1, AA446652.1, AA256802.1, AA150300.1, AA148791.1, AA086458.1, AA030012.1, W05069.1, N51389.1, R34884.1, AI158210.1, AW785190.1, AV305650.1, AU080152.1, AI987624.1, AI810108.1, AI764741.1, AI607860.1, AI546326.1, AI388669.1, AU033961.1, AI144326.1, All 13962.1, AI020516.1, AA951467.1, AA736165.1, AA701889.1, AA700625.1, AA504833.1, AA404221.1, AA404687.1, AA159318.1, H84256.1, H34335.1, H05385.1, AC021561.3, AP001490.1, AC025405.2, ACOl 1945.3, AL354740.4, AL137801.1, AC068548.2, AC027395.2, AC018358.6, AC068739.2, AC026022.2, AC021088.2, AC068386.1, AC020552.3, AC018966.3, AC007721.15, AC016427.3, AC015622.3, AC009703.2, AC005910.4, AC002320.1, AL161452.3, AP001257.1, AL022276.1, AC009522.3, AC063940.4, AC025005.2, AC016572.4, AC008513.6, AC027074.2, AC012184.3, AC016883.3, ACOl 1794.4, AC009871.5, AC010966.2, AC015676.3, AC024237.3, AC018232.1, AC018272.1, AF165146.1, AC006171.1, AC004847.1, AL356461.1, AL159154.3, AL162399.3, AL133410.10, AL162589.1, AL136001.1, AP001078.1, AP000899.2, AP001029.2, AP001113.1, AL008875.1, SEQ ID NO.154 NGO-Br-49 MK4111/T3 5'

NM_004349.1, S78158.1, D14821.1, D43638.1, D14289.1, D13979.1, X79990.1, NM_009822.1, X79989.1, D32007.1, S78159.1, D14823.1, AF018276.1, AF018275.1, AF018283.1, D14822.1, AF018274.1, NM_009824.1, AF038029.1, AB010420.1, AB010419.1, AF018277.1, AB013280.1, AF052215.1, S74096.1, NM_005187.2, AF069747.1, NM_005093.1, AF068266.1, AF052210.1, AF013970.1, AF039200.1, AF212198.1, AF076455.1, AL034421.4, AC007842.1, AF022978.1, AB037757.1, AC023838.1, AC004011.1, AC006208.3, AE001039.1, AC002297.1, AC001229.1, AL133445.2, AL049766.14, AL096843.11, AL008634.1, Z84466.1, AL022721.1, AJ005682.1, U01337.1, AJ005077.1, L24038.1, AP000385.1, X77694.1, H18342.1, AW659083.1, AL134801.1, H18378.1, R91340.1, AW409814.1, AA597034.1, AW411004.1, AI880924.1, AW047315.1, AW526016.1, AW319793.1, AW319604.1,

AW125686.1, AW060692.1, AV127503.1, AI606504.1, AA996736.1, AI407074.1, AI176767.1, AI171652.1, AI152215.1, AI046358.1, AA914494.1, AA822901.1, AA674424.1, AA529559.1, AA261311.1, AA222118.1, AA222011.1, AA963424.1, W39519.1, N75171.1, R70443.1, AV170567.1, AA924939.1, AI169429.1, W89980.1, AA015563.1, AC015952.3, AC013551.1, AF181450.1, AC068674.1, ACOl 1671.3, AC009149.4, AC021125.2, AL121906.12, AC031998.2, AC013552.4, AL158160.1, AC012485.4, AC009989.6, AC006431.8, AC021193.3, AC022029.3, AC009438.2, AC027023.2, AC019055.3, AC007779.2, AC015667.3, AC027146.1, AC021291.3, AC023300.3, AC023545.2, AC015598.3, AC023438.2, AC020713.2, AC016279.2, AC007936.1, AL109823.21, AL160211.1, AL135961.1, APOO 1892.1, APOO 1637.1, AP000798.1, AP000662.1, SEQ ID NO.155 NGO-Br-49 MK4111/T73'

NM_004349.1, D14821.1, D43638.1, D14289.1, D13979.1, X79990.1, S78158.1, NM_009822.1, D32007.1, X79989.1, AF018282.1, AC007161.1, AC003006.1, AE000663.1, ACOl 1494.2, AC012147.7, AC004846.2, AC005058.1, AC007630.3, AF109907.1, M13209.1, AL034365.1, Z70782.1, AL031176.7, S55844.1, X67119.1, X16144.1, X01978.1, K03329.1, J02070.1, K01729.1, M17293.1, AJ224792.1, AJ224790.1, D49508.1, AI420591.1, AI033811.1, H94855.1, AW411005.1, AI167424.1, AW409570.1, AI264845.1, AA904353.1, F02579.1, N75054.1, AU041415.1, AW192965.1, AA992855.1, R38996.1, AV 162276.1, N86959.1, AA247686.1, AV240937.1, AI078840.1, AV245662.1, F01701.1, AI080687.1, AV347330.1, N88058.1, AA463390.1, AA095305.1, AI825475.1, H46432.1, AW450741.1, AW063104.1, AI723657.1, AI604144.1, AI574526.1, AA257797.1, AW859690.1, AW177930.1, AW849569.1, AW849241.1, AW575067.1, AW257554.1, AV332137.1, AV153186.1, AI476165.1, AI445297.1, AI445224.1, AI181996.1, All 16642.1, AA469797.1, AA469776.1, AA194741.1, AA125063.1, AC015952.3, AF181450.1, AC068674.1, AC010295.4, ACOl 7222.1, AC008197.2, ALl 36968.4, AL096708.33,

SEQ ID NO.156

NGO-Br-49

MK571/T3 5'

NM_004349.1, S78158.1, D14821.1 , D43638.1, D14289.1 , D13979.1, X79990.1, NM_009822.1, X79989.1 , D32007.1 , S78159.1, D14823.1, AF018276.1, AF018283.1, AF018275.1, S74096.1, D14822.1, AF018274.1, NM_009824.1 , AF038029.1, AF018277.1, AB010420.1, AB010419.1, AB013280.1 , AF052215.1, NM_005187.2, AF018278.1, AF069747.1, NM_005093.1, AF068266.1, AF052210.1, AF013970.1, AF039200.1, AF212198.1, AF076455.1, AL034421.4, AC010285.4, AC007842.1, AF022978.1, AB037757.1, AC023838.1, AC004011.1, U91322.1, AC006208.3, AE001039.1, AC001229.1, AL133445.2, AL049766.14, AL096843.1 1, AL031682.1, AL008634.1, Z84466.1, AL022721.1, AJ005682.1, U01337.1 , AJ005077.1, L24038.1, AP000385.1, X77694.1, H18342.1, AW659083.1, AL134801.1 , H18378.1, R91340.1, AW409814.1, AA597034.1, AW41 1004.1, AI880924.1, AW047315.1, AW526016.1, AW319793.1, AW319604.1, AW125686.1, AW060692.1, AV127503.1, AI606504.1 , AA996736.1 , AI407074.1 , All 76767.1, AI171652.1, AI152215.1, AI046358.1, AA914494.1, AA822901.1, AA674424.1, AA529559.1, AA261311.1, AA222118.1, AA222011.1, AA963424.1, W39519.1, N75171.1, R70443.1, AW433933.1, AV170567.1, AI555661.1, AA924939.1 , AI169429.1, AA196015.1, AA120052.1 , W89980.1, AA015563.1, AC015952.3, AC013551.1, AF181450.1, AC068674.1, ACOl 1671.3, AC009149.4, AC021 125.2, AL121906.12, AC031998.2, AC013552.4, AL158160.1, AC025418.5, AC010313.4, AC016533.5, AC023924.2, ACOl 1094.2, AC027737.2, AC050049.1, AC038905.1, AC013648.3, AC012485.4, AC009989.6, AC012154.9, AC006431.8, AC021 193.3, AC012626.4, AC009078.4, AC022029.3, AC009438.2, AC027023.2, AC019055.3, AC007779.2, AC026911.2, AC026958.2, AC015667.3, AC027146.1, AC021291.3, AC023300.3, AC023545.2, AC015598.3, AC006404.20, AC023438.2, AC020713.2, AC016279.2, AC009878.3, AC007936.1, AL16021 1.1, AL135961.1, AP001892.1, AP000798.1, AP000662.1,

SEQ ID NO. 157 NGO-Br-49 MK571/T7 3'

NM_004349.1, D14821.1, D43638.1 , D14289.1, D13979.1, X79990.1, S78158.1 , NM_009822.1, D32007.1, X79989.1, AF018282.1 , AE003739.1, AC007161.1, AC003006.1, AE000663.1, AC012147.7, AC004846.2, AC005058.1, AC007630.3, AL031 176.7, S55844.1 , X67119.1, X01978.1, AI420591.1, AI033811.1, H94855.1, AW411005.1, AI167424.1 , AW409570.1 , AI264845.1, AA904353.1 , F02579.1, N75054.1, AU041415.1, AW192965.1, AA992855.1, R38996.1, AV162276.1, N86959.1, AA247686.1, AV240937.1, AI078840.1, AV245662.1, F01701.1, AI080687.1,

AV347330.1, AA463390.1, N88058.1 , AI825475.1, AA095305.1, H46432.1, AW450741.1, AW063104.1, AI885714.1, AI723657.'l, AI604144.1, AI574526.1, AA257797.1, AW859690.1, AW575067.1, AW257554.1, AV332137.1, AV153186.1, AI476165.1, AI445297.1, AI445224.1, AI181996.1 , All 16642.1, AA469797.1, AA469776.1, AA194741.1, AA125063.1, AC015952.3, AF181450.1, AC068674.1, AC017222.1, AC008197.2, AL096708.33, ACOl 1005.4, AC024483.2, ACO 12431.5,

SEQ ID NO.158 NGO-Br-50 MK253/T3 5' NM H3235.1, AFl 16910.1, AKOOl 121.1, AE003484.1, AL135784.4, L33180.1, L22858.1 , Z83744.1, L35905.1, X71415.1, AF178030.1, Z95126.1, Z98266.1, AB025632.1, X78287.1 , AC008969.5, AC027659.1, AC024799.1, AC013453.1, AC007038.3, AC007591.2, AC005284.1, Y14344.1, AA543176.1, AW237908.1, AA153374.1, AA144562.1, AAl 14761.1, AA460045.1, AW834734.1, H34369.1, AA549506.1, AA623764.1 , AA797275.1, AW246359.1 , AW702080.1 , AA083888.1 , AA199399.1 , AA461807.1, AW860954.1 , AI681138.1 , C72137.1, AW836479.1, AW416148.1, AV141668.1, AI678836.1, AI035692.1, C84814.1, AA768917.1, AA722287.1, R66162.1, R59232.1, AC008768.4, AC008159.1, AC026712.3, AC008419.4, AC010348.3, AC008550.3, AC018857.3, AC013905.1 , AC008035.8, AC046148.2, AC010243.3, AC016555.4, AC026300.2, AC012586.6, AC015725.3, AC009591.3, AC010897.3, AC016998.1, AC012338.2, AL136987.2, AC021874.12, AC021023.4, AC018916.6, AC012041.8, ACOl 1312.5, AC055789.2, AC067752.2, AC026780.2, AC010457.5, AF260012.1, AC026167.2, ACOl 1050.4, ACOl 1148.4, AC016099.3, AC026205.3, AC023780.2, AC023571.2, AC024598.2, AC020755.2, AC021874.11 , AC020856.1, AC024159.1, AC006595.1, AC006788.1, AL355353.3, AL139143.4, AL138885.4, AL355482.1, AL354864.1, AL161639.4, AL160008.1, AP001280.1, AP001085.2, AP000577.1,

SEQ ID NO.159 NGO-Br-50 MK253/T7 3'

NM J13235.1 , AFl 16910.1 , AKOOl 121.1, AC006349.3, AL023807.6, AC008082.12, AC008160.11, AF060568.1, AF016679.1, U51999.1, X52871.1, M 15387.1, AE003826.1, AC007056.4, AF088189.1, AC006216.1, AF099810.1, AC002397.1 , AE000092.1 , ALl 63221.2, U96131.1 , ALl 17672.3, AL049758.11 , AL035427.17, AL022578.1 , APOOl 676.1 , D87952.1 , AP000403.1, AW246572.1 , AA827562.1 , AA514488.1, AI190270.1, AL135673.1 , AI539185.1, AA778031.1, AA083889.1 , AW874309.1, AA255533.1, AW662264.1, AI539830.1, AA532881.1, F19104.2, AA459956.1, AW701839.1, AA749416.1, AI972095.1 , AI874853.1, AW656237.1, AW793352.1 , AW793354.1, AA247961.1, AW246359.1, AW793373.1, AU042596.1, N66268.1 , AA271691.1, AI630888.1, AW522844.1, AA255505.1 , AI502808.1, AA384265.1 , AW438881.1, AA729375.1, AA364111.1, AW363733.1, AW638275.1, AA538198.1 , AV084911.1, AA702934.1,

AI940043.1, AW428205.1, AV008608.1, AW702080.1, ALl 34250.1 , All 59057.1, AA711797.1, AA 120508.1 , T06791.1, AV319126.1, AA739069.1, AV319605.1, AV038838.1, U94841.1, AA461807.1, AW803473.1, AI937621.1, AI673094.1, AI105163.1, AA638281.1, AA559086.1, AA473595.1, AA331632.1, H87048.1, AC026712.3, AC008768.4, AC008159.1, AC068577.1, AC020880.2, AC021229.2, AC012557.7, AC021482.4, AC022782.2, AC024656.2, AC020742.2, AC019262.3, AL354712.2, AL354656.1, AP000908.1, AC024898.7, AC009716.3, AC068132.2, AC020930.4, AC010393.4, AC010266.7, AC010500.4, AC034195.2, AC023478.2, AC024928.4, AC049149.1, AC021380.3, AC023761.2, AC016498.4, AC026219.1, AC026198.1, AC026188.1 , AC025978.1, AC005653.8, AC017064.4, ACOl 1981.3, AC022668.3, AC022335.6, AC022002.2, AC022989.2, AC021141.2, AC016397.4, AC009673.2, AC013573.2, ACOl 7933.1 , AC008031.3, AC010167.1, AF165425.1, AC007715.1, AL096868.7, AL353585.3, AL160403.3, AL160281.3, Z82199.1, AL132638.1, AP001445.1, APOOl 194.1, APOOl 130.1,

SEQ ID NO.160 NGO-Br-50 MK496/T3 5' NM H3235.1 , AFl 16910.1, AKOOl 121.1, AE003484.1, L33180. I , L22858.1, Z83744.1, L35905.1, X71415.1. Z98266.1, AC008969.5, AE003629.1, AC000370.1, AC013453.1, AC007591.2, AE001718.1, AC004673.1, AC005751.1 , AC002995.1, AL031670.6, Z81133.1, AL035467.23, AA460045.1, AA153374.1 , AA144562.1, AW246359.1, AA549506.1, AW834734.1, AA623764.1, AA083888.1, AAl 14761.1, AL134250.1, AA543176.1, AW702080.1, AA797275.1, AA199399.1, AW428205.1, AA461807.1, AA71 1797.1, AW237908.1, AA538198.1 , AA120508.1 , AI987530.1, AI681 138.1, C72137.1, AW836479.1 , AW559878.1, AW416148.1, AU039592.1, R66162.1 , R59232.1, AC026712.3, AC008768.4, AC008159.1 , AC046148.2, AC013905.1, AC010190.7, AC063946.3, AC025265.5, AC010243.3, AC016555.4, AC026300.2, AC015725.3, AC010897.3, AL136987.2, AC021874.12, AC021023.4, ACOl 1312.5, AC0121 14.2, AC067752.2, AC010457.5, AC010381.4, AC025546.3, AC009135.6, AC068121.1 , AC067828.1, AC025700.3, AC018508.4, AC025039.3, AC022526.4, AC016099.3, AC021736.3, AC010785.3, AC021242.3, AC023860.2, AC024598.2, AC021874.1 1 , ACO20856.1 , AF230637.1, AC016906.3, AC015747.1 , AC0201 15.1, AC007300.5, AC004387.1, AL353194.6, AL138885.4, AL355482.1, AL354933.1, AP001869.1,

SEQ ID NO.161 NGO-Br-51 MK071/T3 5'

NM_003137.1, U09564.1 , NM H6795.1, AB012290.1, AJ224115.1, Z99128.1, NM_009274.1, U92456.1, AB006036.1, NM_003138.1, U88666.1, AF043288.1 , AC005070.1 , AE003811.1, AF133093.1, AF043289.1, ABO 17067.1 , AC023279.2, AC005220.1, AL160231.2, AL023634.1, AB023037.1, D13447.1, AE003484.1, AF002725.1, AE000541.1, AE001458.1, AF052290.1, AL021 127.2, AL021180.1, AL02231 1.5, AB035133.1, AB006605.1, AW611721.1, AA060080.1, AA492926.1, AL048784.3, AW006865.1, AU051027.1, AL046120.2, AA382461.1, AW500688.1 , AW637436.1, AW701629.1, AJ396085.1, AA864027.1, AA211241.1, AI605657.1 , AW635365.1, AW422773.1, AW421817.1, AW128008.1, AI722256.1, AW629710.1 , AW381192.1 , AW153931.1, AI626169.1, N28924.1 , AI595541.1, AI038250.1, AI854277.1, AI787785.1, AI599584.1, W92175.1, AA428487.1 , N23469.1, AW701402.1, AW462697.1, AI848239.1 , AI414590.1, AI184192.1, AA553654.1, AW149364.1, AW016345.1, AI869878.1, AI830963.1, AI808855.1 , AI808450.1, AI555245.1, AI248681.1, AI247996.1, AI200995.1, AI199780.1, AI127471.1 , AI075315.1, AI032748.1, AI018413.1 , AI018139.1 , AI000892.1 , AA573426.1 , AA479899.1 , W92176.1 , N35218.1, H98745.1 , AA537749.1 , AI296396.1 , W12836.1, AW668908.1, AW392218.1 , AI810017.1, AA968079.1, AA062255.1, AW736509.1, AW705048.1 , AW704786.1, AW277878.1, AW277356.1, AW277342.1, AV375020.1, AV293419.1, AV287373.1 , AV284759.1, AV234361.1, AW099987.1, AW036092.1, AI960739.1, AVI 74923.1 , AI794688.1, AVI 18805.1, AI703778.1, AI507200.1 , AA972378.1, AA891069.1, AA863700.1, AA086829.1, AL133507.3, AC022452.2, AC017471.1, AC022525.3, AC023305.2, AC022106.2, ACOl 1540.2, AC010787.3, AC021963.3, AC0239I3.4, AC016956.6, AC060815.2, AC068798.4, AC024102.5, AC023158.4, AC020570.3, AC023052.13, AC025765.3, AC025178.3, AC022444.3, AC022423.3, AC008411.3, AC008803.3, AC023779.2, AC024479.3, AC037484.1, AC016985.4, AC019298.3, AC027165.1, AC009072.2, AC016956.5, AC013441.2, AC013907.1, AC008108.1, AL160162.4, AL133356.3, AL157696.2. AL009027.1,

SEQ ID NO.162 NGO-Br-51 MK071/T7 3' Z99128.1, NM_003137.1, U09564.1, NM_016795.1 , ABO 12290.1, AJ2241 15.1, AJ005937.1, AE003588.1, AC0041 16.1, AL031534.1, AL137450.1, AL023534.1, AW594310.1, AW082913.1, AI672149.1, AI126291.1, AW338805.1, AA490202.1 , AA629288.1 , AW848261.1, AA921804.1 , R78142.1 , AI076709.1 , AW510886.1 , AW275479.1 , AW376532.1, T77446.1, AA284106.1, R29335.1, AA323127.1 , R78141.1, W25929.1, AW123035.1, AI648020.1, AA899108.1, AU024203.1, AU020306.1, N76402.1, N77083.1, AA383402.1, AW674276.1, AW275654.1, AW103361.1, AW091907.1, AW039956.1, AW008221.1, AI799557.1, AI598063.1, AI458262.1, AA915976.1, AA373583.1, AA059466.1 , W73010.1 , N36259.1 , N24536.1 , H26379.1 , AW727130.1 , AW702067.1 , AW489711.1, AW421443.1 , AW144384.1, AVI67622.1, AV060461.1, AI697622.1, AI630968.1, AI325483.1, AI235699.1, AI210173.1, AI152339.1, AI034064.1, AI006140.1, AA798365.1, AA764641.1, AA450512.1, AA408261.1, AA122933.1, AA097370.1, AA024303.1, W36820.1, Wl 1581.1, W08677.1, D19317.1, D24037.1, AL157823.3, AP001449.1, AL139347.2, AC026566.1, AC018197.1, AC024107.9, AC021650.9, AC008810.4, AC026466.3, AC026959.2, AC023271.3, AC024193.2, AC009792.4, AC020730.2, AC021155.2, AF178220.1, AP000794.1,

SEQ ID NO.163 NGO-Br-52 MKU 1/T3 5'

NM_003373.2, NM_014000.1, M33308.1, NM_009502.1, L18880.I, J04126.1, Y00312.1, L13300.1, S52276.1, S52271.1, AF067624.1, AL163852.1, AL138646.2, AC007138.1, AF047564.1, U82828.1, AL161552.2, AL161493.2, AL161492.2, U55724.1, Z98946.15, AL080253.2, X52256.1, AC007347.3, AC002485.1, AF107675.1, AC005026.1, AC008170.2, AC007560.3, AF147259.1, AC004063.1, AL163290.2, AL132793.24, AL161506.2, AL049871.3, AP001745.1,

AP001619.1, AP001800.1, X91233.1, AB033053.1, AL048129.1, AA853564.1, AA375439.1, AV441119.1, AA585825.1, AW202184.1, AW577790.1, AW498327.1, AV404553.1, AV402299.1, AU004063.1, AU004045.1, AU003308.1, AI042965.1, AJ003662.1, AC025425.4, AC021191.3, AC006874.1, AC025212.2, ACOl 1797.4, AC025104.2, AC015687.3, AL354652.3, AP001925.1, AP001808.1, AP000838.1, AC024933.7, AC023598.10, AC022072.8, AC051642.2, AC015891.10, AC068973.1, AC055869.2, AC068886.1, AC025477.3, AC018753.3, AC008859.4, AC026557.2, AC068246.1, AC022993.3, AC012211.3, AC046149.2, AC012068.3, AC026824.2, AC026087.3, AC034111.1, AC025061.2, AC020672.3, AC012252.4, AC026566.1, AC018911.4, AC015938.3, AC018973.3, AC022041.2, AC023916.2, AC011298.2, AC021950.1, AF216674.1, AC013695.1, AF191252.1, ALl 18506.16, AL161442.7, AL139157.4, AL138744.7, AL136980.3, AL354744.1, AL354696.1, AL137022.7, AP001954.1,

SEQ ID NO.164

NGO-Br-52

MK111/T73'

NM_003373.2, NM_014000.1, M33308.1, ALl 21751.12, AC007237.3, AC005405.1, Z50070.2, AC006332.3, NM_005509.1, AE003635.1, AC006979.2, AF204929.1, AFl 85647.1, U80443.2, AC000104.1, AL138478.2,

AL078605.30, AJ005821.1, D90900.1, AB017062.1, AL043388.1, AL048130.1, AW613219.1, AL042874.1, AL047646.1, AI564569.1, AW338462.1, AI871828.1, AW341948.1, AI744828.1, AI754173.1, AI889651.1, C06476.1, AI564600.1, AW189900.1, AI583605.1, AW316646.1, AA776250.1, AW268882.1, AW268623.1, AI833189.1, AA564112.1, AA486728.1, AA458903.1, AW067932.1, AW026609.1, AA284505.1, AI808349.1, AI041865.1, AA744683.1, AA744677.1, N35013.1, AI367320.1, AW070464.1, AA723251.1, AA478033.1, AI161355.1, AA521095.1, AI956152.1, AI753120.1, AA653613.1, AI890467.1, AA173528.1, AA160880.I, AA653144.1, W72421.1, AA031689.1, AI095313.1, AI243169.1, AA744691.1, N27658.1, AA909152.1, AI381956.1, AA548423.1, AI240491.1, AA705238.1, AA150688.1, W76280.1, H24935.1, AI290052.1, AI953995.1, AA099284.1, AI003089.1, AI041158.1, AA299485.1, H47593.1, R87481.1, H06272.1, AA670014.1, AI750559.1, AW081510.1, H62215.1, T92938.1, F32136.1, W15223.1, H28559.1, AA045285.1, H57205.1, AW438657.1, AA490932.1, R78919.1, AA165451.1, AI206471.1, AA370855.1, AI952389.1, AA853565.1, AWl 18302.1, AW193451.1, T92716.1, H51597.1, AA831147.1, H38452.1, AA776247.1. T23463.1, T93331.1, AI694888.1, H97605.1, T92712.1, AA904909.1, R62767.1, AC025425.4, ALl 10115.28, AL138753.3, AL139114.3, AC015970.4, AC010278.5, AC008883.3, AC008446.3, AC012583.3, AC021516.4, ACOl 1944.3, AC024317.2, AL139042.3, AL162411.1, AL023673.1, Z81488.1, AC041006.2, AC036146.2, AC068429.1, AC068020.1, AC026458.3, AC024492.2, AC015873.2, AC022770.4, AC010579.8, AC025134.1, AC023828.1, ACOl 1066.4, ACOl 1750.3, AC019782.1, AC013663.1, AC010213.2, AC009339.1, AL096888.26, AL161671.5, AL161653.7, AL160172.4, AL109824.23, AL135901.4, AL162759.1, AL136301.4, AL136985.1, AL137785.2, AP000863.1, AP000784.1, SEQ ID NO.165 NGO-Br-53 MK282/T3 5'

X98494.1 , ALl 33363.1 , AE002611.1, Z83848.1 , AF036707.1 , AFl 18145.1 , AC002060.3, AF022981.2, AF 125969.1 , D87023.1, AC008757.5, AE003498.1, U76408.1, AC009303.2, AF197947.1, AF242181.1, AE003844.1, AE003477.1, NM_011241.1, AF098623.1, AF098622.1, AF098621.1, AF098620.1, AF098619.1, AF098618.1, AF098617.1, U48809.1, AF046092.1, AF046084.1, U53154.1, AF057293.1, AE000661.1, U20857.1, Y14591.1, AJ242625.1, Y18000.1, Y14592.1, D87010.1, AC010252.3, AC008174.2, AF216973.1, AF220200.1, AF030052.1, Z73905.1, U 10577.1, U67889.1, AL031652.1, AK001686.1, AP000501.1, ABOl 1164.1, AA848124.1, AW365568.1, T24602.1, AW365559.1, AA603307.1, AI844833.1, W33952.1, W75630.1, W64795.1, AVI 13531.1, AVI 13797.1, AVI 14982.1, AI709759.1, AW365540.1, AI137651.1, AI070777.1, AW376006.1, AI546038.1, C94041.1, AV294399.1, AI959638.1, AI793667.1, AI406906.1, L37652.1, AV427570.1, AV409781.1, AW638224.1, AW560695.1, AW517166.1, AJ398790.1, AW345759.1, AW187449.2, AV314465.1, AV312363.1, AWl 28487.1, AI994267.1, AV024242.1, AV020965.1, AI641607.1, AA388279.1, R90246.1, T75711.1, AV420624.1, AW703701.1, AW604496.1, AW579832.1, AW443988.1, AW373650.1, AW361293.1, AW361221.1, AL038706.1, C99888.1, AI384793.1, AA147878.1, W26394.1, T92366.1, T90227.1, AC007881.3, AC007345.2, AC007342.2, AC009673.2, AC016033.2, AC025138.2, AC018348.1, AC023310.1, AC027794.1, AC026150.1, AC036148.2, AC022113.4, AC020980.3, AC016621.4, AC027472.2, AC018409.3, AC018491.7, AC014030.1, ACOl 1402.5, AC026275.3, AC009792.4, AF 178220.1 , AC006844.1 , AC027245.1, AC013451.7, AC012931.1 , AC009682.3, AC023659.2, AC025303.1, AL355178.2, AC034214.3, AC027621.3, AC064793.1, AC025856.2, AC015454.3, AC022783.2, AC018510.3, AC015672.3, AC014497.1, AL353612.5, AL163151.1,

SEQ ID NO.166 NGO-Br-53 MK282/T7 3'

X98494.1, AF135002.1, AI760199.1, AI742680.1, AW384883.1, AI284853.1, AI222419.I , AA992199.1 , AW044708.1, AI862023.1, AI681988.1, AI867639.1, AI955575.1, AA992130.1 , AI087795.1 , AI263606.1, AA025657.1, AA083314.1 , AI094541.1, AA847842.1, AA731098.1, AA047545.1 , AI420376.1, W80758.1, AA770202.1, AI357730.1, AW592097.1, AA909134.1 , AW369791.1 , AI271912.1, AA810790.1, N68965.1, AI806559.1, T97061.1 , AI056034.1, AW591044.1, AA668325.1, AA504113.1, AA3471 16.1, AW606827.1, AW608731.1, AI244315.1, AA837327.1, Z25156.1, AI809694.1 , AA888598.1, H88801.1 , F00393.1, AW1301 17.1, AI884600.1, AI679865.1, AI679289.1 , AI386428.1, AI000365.1, AA162148.1, AW556570.1, AA213194.1, H89025.1, AI177638.1, T96950.1, AA881872.1, AV146345.1 , AA916136.1 , AW539498.1, AV077858.1, AI647220.1, AI326008.1 , AA590060.1 , C02251.1 , AI406906.1, AW632569.1, AW532104.1, AA817668.1, AV218492.1, AA619205.1, AC007881.3, AC021225.3, AC027794.1,

SEQ ID NO.167

NGO-Br-54

MK123/T3 5'

AK001917.1, AF035606.1 , NM_013232.1, U58773.1, NM_011051.1, U49112.1, AC008925.3, AC007790.1, AC004485.1, AC004025.1, AC004923.2, AC008078.11, AC002288.1, AEOOl 146.1, AC000385.1, U73627.1 , AC000389.1,

AL078590.27, AL049839.3, Z73424.1, Z95397.2, U40412.1, X14938.1, U03396.1, AB020682.1, AB020863.1, D89223.1, AC010083.5, AF203377.1, AE003750.1, AE003637.1, AE003550.1, AC007514.5, AC010198.8, AC012039.10, AC004893.1, AC004128.1, AF090189.1, AC006207.5, AC005007.1, AC005891.1, AC002366.1, AL031664.1, AL161587.2, AL161577.2, AL133453.2, U22376.1, Z46267.1 , Z97055.1, AL049649.4, AL049713.19, AL035246.13, AL031 177.1, AL023805.1, AL021879.3, AL031599.1 , AL022198.1, AL109787.1, AL022604.1, U49956.1, AB012766.1, AB022220.1 , L20858.1, AW439592.1, AW058001.1, AI982775.1, AI912340.1, AA825538.1, AW513884.1, AW074361.1, AI872206.1, AI798286.1, AI522238.1 , AI758821.1, AW474823.1, AI572080.1, AA831357.1, AW337178.1, AI690445.1, AI360561.I , AA775261.1, AI140796.1, AA835492.1, AI361820.1, AW004890.1, AA100279.1, AI277190.1, AW517943.1, AI917776.1, AI469550.1, AI015234.1, AA581345.1, AI689240.1 , AI744762.1 , AW769512.1, D20022.1, AA122332.1, AI811224.1, AI355770.1, AW265061.1 , AA485257.1 , AA092467.1, AI471817.1, AI702026.1, T34498.1, AI597962.1,

AW545016.1, AW544484.1 , AI852320.1, AI839826.1, AV173766.1, AI646046.1, AI415428.1, AA959713.1, AA855573.1 , AAl 16476.1 , C85464.1 , AW545749.1 , AV269112.1 , AV262681.1, AI884872.1 , AVI 69832.1 , AV064737.1 , AV012020.1 , AU019447.1 , AV299656.1, AV154525.1, AV335637.1, AV301925.1, AI835781.1, AV160371.1, AV139152.1, AV138338.1, AV0651 17.1, AV051902.1, AV245530.1 , AV338545.1, AV273829.1, AV214086.1 , AV251164.1 , AV249977.1 , AV234666.1 , AV163377.1, AV167956.1, AV136391.1, AV064067.1, AV062993.1, AV061701.1, AV057279.1, AV028650.1, AV232758.1, AV064377.1, AV063220.1, AV062771.1, AV059304.1, AV244517.1 , AV215643.1, AV301794.1, AI706252.1, AW254397.1, AA956495.1, AI180308.1, AW465410.1, AC061974.2, AC060789.2, AC019267.3, AC026124.3, AC021067.5, AC025543.2, AC018428.3, AC024418.2, AC021067.4, AL163533.5, AL355887.1, AC068587.1, AC032016.2, AC009664.4, AC027523.2, AC026135.2, AC025830.2, AC013389.3, AC015474.3, AC023518.3, ACOl 1774.4, AC012552.2, AF231129.1, AC016460.1, AC013750.4, AC015980.1, AL161658.3, AL050340.7, AL136373.2, AP001848.1, Z99293.1 ,

SEQ ID NO.168 NGO-Br-54 MK123/T7 3'

AK001917.1 , AF035606.1, NM_013232.1, U58773.1, NM_011051.1, U491 12.1, AC008925.3, AC007790.1, AC004485.1 , AC004923.2, AC008078.i l, AEOOl 146.1, AC000385.1, U73627.1, AC000389.1, AL049839.3, Z95397.2, U03396.1, D89223.1, AW439592.1 , AW058001.1, AI982775.1, AI912340.1, AA825538.1, AW513884.1, AW074361.1, AI872206.1, AI798286.1, AI522238.1, AI758821.1, AW474823.1, AW337178.1, AI690445.1, AI572080.1, AA831357.1, AI360561.1, AA775261.1 , AI140796.1, AW517943.1, AW004890.1, AI361820.1, AA835492.1, AI917776.1, AA 100279.1 , AI277190.1, AI469550.1, AI015234.1, AI689240.1, AW769512.1, AA581345.1, AI744762.1 , D20022.1 , AAl 22332.1, AI81 1224.1, AI355770.1, AI471817.1, AI702026.1, AW265061.1, AA485257.1, AI597962.1, AA092467.1, T34498.1, AI624976.1 , AI811439.1 , AV262681.1, AV249977.1, AW545749.1 , AW545016.1, AW544484.1, AV335637.1, AV303323.1, AV299656.1, AV324700.1, AV273829.1, AV269112.1, AV251768.1, AV235453.1, AV232758.1, AV214086.1, AI852320.1 , AI839826.1 , AI835781.1 , AVI 73766.1 , A V 138338.1 , A V070618.1, AV065117.1 , AV064737.1 , AV063220.1 , AV062993.1 , AV062771.1, AV061701.1, AV057279.1, AV051902.1, AV028650.1, AV012020.1, AI646046.1, AA959713.1, C85464.1, AAl 16476.1, AV303717.1, AV338545.1 , AV301925.1 , AV296289.1, AV259612.1, AV245530.1, AV244517.1 , AV234666.1, AV215643.1, AV210921.1, AV167956.1, AV154525.1, AV153177.1, AV152413.1, AV136391.1, AV132769.1, AV064791.1, AV064377.1 , AV064067.1, AV059304.1, AC061974.2, AC060789.2, AC019267.3, AC027145.1, AL163533.5, ACOl 1699.5, AC025164.7, AC026102.5, AC055810.2, AC068587.1, AC034259.2, AC032016.2, AC025615.2, AC027523.2, AC026135.2, AC025965.2, AC025543.2, AC013389.3, AC023518.3, AC018428.3, ACOl 1774.4, ACOl 1699.4, AF231129.1, AF228730.1, AC013750.4, AC007310.1, AL096888.26, AL353663.2, AL050340.7, APOO 1848.1,

SEQ ID NO. 169

NGO-Br-56

MK271/T3 5'

Ul 3369.1, X03205.1, Ml 0098.1, K03432.1₎ X00686.1, X82564.1, Mi l 188.1, X01117.1, V01270.1, X06778.1, K01593.1, X00640.1, AF173638.1, AF173637.1, AF173636.1, AF173635.1, AF173634.1, AF173633.1, AF173632.1, AF173631.1,

AF173629.1, AF173628.1, AF173627.1, AF173625.1, AF173624.1, AF173623.1, AF173622.1, AF173621.1, AF173620.1, AF173619.1, AF173618.1, AF173617.1, AF173616.1, AF173615.1, D84514.1, AF173630.1_> AF173626.1, AF173613.1, X04025.1, X59734.1, AF173612.1, AF173610.1, AF173609.1, AF173608.1, AF173607.1, AF173606.1, M97576.1, X59733.1, M91180.1, AF173611.1, AFl 15860.1, X02995.1, J00999.1, K01373.1, AF173614.1, AF173605.1, AF169014.1, X98843.1, M91182.1, M91179.1, M91183.1, M91181.1, X98841.1, X98846.1, LI 1288.1, X98844.1, AF102857.1,

AJ270031.1, AJ279506.1, U87963.1, X98840.1, X98837.1, NM_007841.1, D50494.1, X98842.1, X98838.1, X98836.1, AJ277531.1, X98839.1, X98845.1, AF030250.1, M33066.1, AJ270032.1, L24123.1, M59402.1, M97575.1, M59384.1, M97573.1, AF157625.1, M59401.1, M59393.1, M59392.1, AF021880.1, M59386.1, M59385.1, AF236803.1, AF236802.1, AJ007613.1, M59396.1, M59390.1, AW794857.1, AW579814.1, AW580540.1, AW601150.1, AW601147.1, AW601146.1, AW803842.1, AW773277.1, AW773263.1, AW579819.1, AW864483.1, AW801020.1, AW579820.1, AW802332.1, AW795520.1, AA409121.1, AW869663.1, AW820465.1, AW860385.1, A W601994.1, AJ241168.1, AU080818.1, AW866280.1, AW841972.1, AW802330.1, AW601111.1, AW866367.1, AW866279.1, AW804859.1, AW604972.1, AW602533.1, AW866444.1, AW803373.1, AW206333.1, AA900286.1, AW866441.1, AW804923.1, AW801069.1, AW607233.1, AW804888.1, AI058227.1, AW793732.1, AW750335.1, AW867019.1, AW868469.1, AW864482.1, AW866513.1, AW803865.1, AW784679.1, AW803389.1, AW841701.1, AW580567.1, AW806873.1, AU023662.1, AW802360.1, AW868472.1, AW841735.1, AW579825.1, AW862813.1, AW802322.1, AW581425.1, AW803866.1, AW802405.1, AW864515.1, AW804909.1, AW802410.1, AW797997.1, AW601124.1, AW864460.1, AW577599.1, AW804949.1, AW869661.1, AW363080.1, AW841738.1, AW804307.1, AW864524.1, AW804302.1, AW601130.1, AW601094.1 , A W868926.1 , AW602408.1 , AW868199.1 , AW773266.1 , AW773181.1, AW773102.1 , AW868212.1 , AW804283.1, AW868207.1, AW864334.1, AW804702.1, AW581420.1, AW803872.1, AW527555.1, AW864530.1, AW864525.1, AW804289.1, AW773310.1, AW864624.1, AW864534.1, AW868455.1, AL353644.2, AL158197.6, ACOl 1630.2, AC023572.3, AC027604.2, AC068192.1, AC026915.1, AC064866.2, AL355134.1, AC069087.1, AC025654.2, AC064825.3, AC025630.1, AC010970.2, AC010554.1, AC018688.4, AC025968.1, AC064844.1, AC027174.1, AC068900.1, AC016828.4, AC006763.1, AL049183.5, AC019020.4, AC025330.2, AP000639.1, AC012647.15, AC008031.3, AC005806.2, AC012386.9, AC060712.1, AC064263.1, AC067527.1, AC067410.1, AC065739.1, AC065644.1, AC065474.1, AC064126.1, AC064016.1, AC063445.1, AC062950.1, AC062797.1, AC062782.1, AC060627.1, AC060379.1, AC060840.1, AC059708.1, AC059318.1, AC059021.1, AC058845.1, AC058431.1, AC057969.1, AC057826.1, AC056563.1, AC057287.1, AC057204.1, AC057180.1, AC056774.1, AC051336.1, AC051335.1, AC050735.1, AC050283.1, AC050278.1, AC050261.1, AC048611.1, AC048549.1, AC043304.1, AC043037.1, AC045314.1, AC044975.1, AC042630.1 , AC042522.1 , AC041360.1, AC041109.1, AC039370.1, AC039308.1, AC039109.1, AC038920.1, AC038318.1, AC037587.1, AC036362.1, AC036088.1, AC035291.1, AC034717.1, AC034385.1, AC034335.1, AC030306.1, AC030238.1, AC029865.1, AC029864.1, AC029705.1, AC035311.1, AC034638.1, AC033832.1, AC029523.1, AC027847.1 , AC056957.1 , AL157407.2, AC025184.3, ACOl 1135.2,

SEQ ID NO.170

NGO-Br-57

MK3710/T3 5'

AF025438.1, AL050353.1, AE003680.1, AC005539.1, AL024458.1, AC004680.2, AC004455.1, AC005966.1, U63928.1, Y18930.1, Z48544.1, X79080.1, AW161135.1, W58718.1, N32746.1, AA313566.1, AA024784.1, AA236836.1,

AA007319.1, R72404.1, AA236656.1, AI090162.1, AI630438.1, AA701988.1, AA852227.1, AA137279.1, AA541923.1, AA000683.1, AI337332.1, AWl 61742.1, AW427494.1, AI828070.1 , AI935340.1 , AI760923.1, AI765742.1, Wl 0638.1, AI630424.1 , H30501.1 , Rl 7187.1 , AI964006.1 , AI304319.1 , W43974.1 , AI765022.1 , AA236789.1 , AW051324.1 , H25699.1 , AW592648.1 , N56244.1 , AW485468.1 , AA865602.1 , AI631687.1 , AA000401.1 , AI765999.1 , N66532.1 , AI888263.1, AW557853.1, H35482.1, AA003291.1, AI076924.1, AI461713.1, AW466965.1, AA637410.1, AW805299.1, AI808237.1, AW536613.1, AA687041.1, AA452088.1, AA916723.1, AI585560.1, AA024685.1, AW152251.1, AI430072.1, AA007455.1, AA759800.1, AA546383.1, AW614505.1, AW772254.1, AA916358.1, AW272790.1, AI336121.1, AA607321.1, AI599140.1, AA521369.1, AI167263.1, AI283104.1, AI140745.1, AA345744.1, AW645427.1, AA995467.1, AA451907.1, N23163.1, AI753758.1, AI841918.1, R77800.1, AA505618.1, AAl 10039.1, AI685071.1, AU024430.1, AA959647.1, A A913049.1, AW636012.1, AI538205.1, AA385531.1, AI073755.1, AW823008.1,

AU024429.1, AI352390.1, R72405.1, R41738.1, AU022981.1, ALl 19291.1, AI171338.1, AL136131.7, AL355349.1, AL138706.1, AC032027.2, AP000831.1, AP000713.1, AC013237.1, AL160276.2, AC069160.1, ACOl 1168.4, AC046152.2, AC017106.3, AC023448.2, AC012335.2, AC006279.6, AC013779.3, AC007345.2, AC007342.2, AC015860.2, AC012273.1, AL353640.6, AL354937.2, AL159996.4, AL138815.4, AL157366.3, AL16I780.3, ALl 63973.1 , ALl 36298.1 ,

SEQ ID NO. 171 NGO-Br-57 MK3710 T7 3'

AL050353.1 , AF025438.1 , AL121924.12, U42838.1, AL031055.1, AL121931.10, AL139076.2, AL024458.1, AC004680.2, AC010889.2, NM_007050.2, AF043644.4, AE003844.1 , AE003787.1, AE003676.1, AE003533.1, AE003519.1, AE003480.1, AE003422.1, AE003217.1, AE002799.1, AC004455.1, AC009320.7, AC007478.1, AC007123.1, AC005548.1, AL163232.2, AC000389.1, AL035633.18, AL032654.1, Z68335.1, AL024473.1, Z92844.1 , ALl 10503.1, AP001687.1 , AP001297.1, AP000459.3, AB005234.1, D17799.1, D17798.1, D17797.1, AB009052.1, AB006621.1,

AI964006.1, AI337332.1, AI765742.1 , AA236789.1, AI304319.1, AA701988.1, AW592648.1 , AI765022.1, AA865602.1 , AI828070.1, AI765999.1, AI760923.1, N66532.1, AI631687.1, AI935340.1, AA916723.1, AW161742.1, AA024685.1, AW152251.1, AW772254.1, AA916358.1, AI336121.1, AW614505.1 , AW051324.1, AI888263.1, N23163.1, AA007455.1, AW272790.1 , Al 167263.1 , AI283104.1 , AA451907.1 , AA995467.1 , AI753758.1 , AA505618.1 , AI073755.1 , AA913049.1 , AI538205.1, AA670386.1, AI352390.1, AA680352.1, AW151295.1, AA720562.1, AA723980.1, AI808237.1,

AW466965.1, AI081040.1, AA992256.1, AI267913.1, AA532854.1, R41738.1, AA928158.1, AWl 17185.1, AA016221.1, AA345744.1, R72405.1, AI140745.1, AI084344.1, AI079153.1, AA852226.1, H89982.1, AI539552.1, AA385531.1, AA236836.1, N50079.1, AI090162.1, AW557853.1, AA858049.1, AW536613.1, AI461713.1, AI599140.1, AI678339.1, AW172462.1, AA637410.1, AI678340.1, R77800.1, AI198148.1, AA546383.1, AW433804.1, AI841918.1, AI585560.1, AW823008.1, AA541923.1, AU024430.1, AA959647.1, AA924460.1, AU022981.1, H30501.1, AA024784.1, T26930.1, AI630424.1, AA137279.1, AI630438.1, AW161135.1, W58718.1, AA607321.1 , AU024429.1, AA963706.1, AA765777.1, AI505865.1, AI963259.1, AL136131.7, AL355349.1, AL138706.1, AL050335.24, AC016073.2, AC023651.2, AL354992.1 , AC026285.4, AC0551 16.2, AC012133.3, AC006756.1 , ACOl 2031.7, AC007953.7, AC027502.3, AC008926.5, AC009679.3, AP000841.1 , AP000783.1, AC012151.5, AC022226.7, AC018728.2, AC068509.1, AC026961.2, ACOl 1036.3, AL136231.5, AL157824.2,

SEQ ID NO.172 NGO-Br-58 MK436/T3 5' AFl 18652.1 , NM_006541.1, AJ010841.1, AFl 18649.1, AFl 18650.1, AFl 18651.1, AC021044.4, W73086.1, AA307154.1, W58564.1, AA363862.1, AW327841.1 , AI902183.1, T06444.1, AW014738.1, AI822071.1, AI813451.1 , AA452335.1, W15560.1, H78479.1 , H59799.1, F11379.1, R63123.1, T83390.1, N24488.1. T83556.1, F07471.1 , N76641.1, T36308.1 , H17884.1, AW743314.1, AL024195.1 , AI892878.1, AI541284.1, AI121283.1, AA423088.1 , AA124189.1, AAl 19742.1, AA086801.1, W14808.1, AA222785.1, AA293188.1, AA985756.1 , AA711181.1, AA218282.1, W33933.1, AI685717.1, T10785.1, AA815685.1, AA273544.1 , AA238334.1, AA157103.1, AI595622.1, AI316625.1 , All 19458.1, AA879644.1, AA879757.1, AA390040.1, AA220693.1, AA217769.1, AA106608.1, W90901.1, W85535.1, AA050409.1 , AA000754.1, W57189.1, W36243.1, AA120515.1 , AI929984.1, AA623076.1, AA939357.1 , AA914937.1 , AA674174.1, W16243.1, AA009010.1, AA536703.1, W01696.1, ALl 17714.1, AW652677.1, AA929573.1, A A667299.1 , AA561056.1, AA177257.1, AA172553.1, AAl 17786.1, AA066010.1, W16154.1, AA048263.1, W76881.1 , C83514.1 , C82658.1, R84921.1, AA198255.1, H96310.1, W23637.1, AA833367.1 , AA822615.1, AA140412.1, AI561434.1, AA545088.1, AA049167.1, AW672942.1, AA222090.1, AA212687.1 , A A866363.1, AA867450.1, AL161648.5, AL139123.2, AL138831.2, AC050138.1, AL158828.4, AL353613.2,

SEQ ID NO.173 NGO-Br-58 MK436/T7 3'

NM_006541.1 , AJ010841.1, AC020610.6, AC005666.1, AC004381.1, AC005972.1, AC004099.1, AC005519.2, AC005899.1, AL034343.17, AL008582.1 1, AC005516.1, AC004601.1, ALl 10120.11, AC01851 1.4, AC005726.1, AL035420.15, Z99128.1, AL022159.1, U91323.1, AC005520.2, AJ011930.1, AC002036.1, AC007676.19, AF205588.1, AC004525.1, AC004961.2, ALl 17337.25, U07000.1, AL034427.1, AL020997.1, AC009946.2, AC004584.1, AC003043.1, AC002070.1, AC004552.1, AC005232.1 , AC002425.1, AC006312.8, AC004968.1 , AC005480.3, AC004821.2, U72787.1, AL355916.1, AL117375.12, Z83840.7, Z94801.1, AL008718.23, AC007240.2, AC004463.2, AC004771.1, AL160231.2, AL121825.19, AL022322.1, AL022238.1, AL021391.2, AL031296.1, AL031681.13, AC005015.2, AC007435.12, AL163262.2, AL121658.2, AL121655.1, Z84486.1, AP001717.1, AC010285.4, AC000003.1, AC004883.2, AC005288.1, AL163265.2, AL133396.1, Z83819.1, AP001720.1, AC009516.19, Z82243.1, AC009145.4, AC002544.1, AC005562.1,

U52111.1, ACOl 1449.6, AC022149.3, AC005907.1, AL133243.1, AL035699.4, AC006509.15, AC007055.3, AL049779.4, AL035658.7, Z82245.1, AP000557.2, AL049759.10, AC006581.16, AL049712.12, AC005778.1 , AC002558.1, Z85996.1, AL024474.1, AL008716.1 , AC005755.1, AC003002.1, AI074462.1, H99205.1, AI038375.1, ALl 19361.1, AA299728.1, AA732982.1, AA602488.1, AI963281.1, AI345497.1, AI371278.1, AA570441.1, AA487512.1, AW149972.1, AI829381.1, AL079763.1, AA614595.1, AA491864.1, AW768439.1, AL135639.1, AI963725.1, AI858632.1, F25696.1, AI610602.1, AI370302.1, AI285709.1, AA618392.1, AA618346.1, AA602468.1, AA306530.1 , H70245.1 , H66503.1, AA708669.1, AA620386.1, AA362670.1, M77904.1, AW877774.1, AW467676.1, AI469586.1, AI375374.1, AI052628.1, AA700279.1, AA613177.1, AA528405.1, AA515254.1 , AA504694.1, AA382130.1, AA347199.1, AA338281.1, AA174071.1, AA167567.1, R86266.1 , ALl 34669.1, AI745457.1, AI734060.I , AI734052.1, AI732085.1, AI370199.1, AI288162.1, AA876148.1, AA846808.1, AA678733.1, AA631915.1, AA489797.1, AA226144.1, AA226095.1, AA225949.1, AW500075.1, AW177901.1, AW177895.1, AW177822.1, AW177816.1, H41308.1, AI073735.1, AA601218.1, AA482054.1, All 74701.1, AW074405.1. N38996.1, AI500315.1, H62161.1, AW847624.1, AI597931.1, AW084237.1, AI791265.1, AI468269.1, AI382183.1, AA194502.1, C05882.1, AA001398.1, AA828783.1, AA688148.1, AA455088.1, AAl 94944.1 , AA487225.1 , AI005219.1 , H73907.1 , AA280681.1 , N55212.1 , AI082472.1 , AA578774.1 , AL 161648.5, AL139123.2, AL109615.18, AC020603.3, AC068727.1, ACOl 1355.3, AL109843.17, AP001885.1, AC068847.1, AC068583.1, AC021991.3, ACOl 1022.4, AC010481.4, AC009038.5, AL050329.11, AC046162.2, AL136458.2, AL162733.2, AC008474.6, AL139815.3, AC005047.2, AC026495.1, AL353596.2, APOOl 809.1, ALl 35787.8, AL157789.1, AC024096.7, AC026603.2, AC007217.2, AL109823.21, AL355837.1, AL353641.1, AP001447.1, AC036206.2, AC008403.5, AC004873.1, AP001787.1, AC063950.3, AC018462.3, AL139384.3, AL139327.12, AC068785.4, AC063962.3, AP000717.1, AC010277.3, AC008484.3, AC064860.2, AC025692.3, AC020781.4, AC023183.2, Z93015.7, AL355392.2, AL354932.4, AL139324.5, AC025265.5, AC026115.10, AC008622.4, AC025778.2, AC025277.2, ACOl 1486.5, AC022307.7, AC012659.3, AC010260.3, AC008671.3, AC025142.2, AL133458.12, ALl 61789.3, AC009027.4, AC023089.2, AL356009.2, APOO 1855.1, AC068077.1, AC022795.3, AC020754.2, AL353794.1, AP001279.1, AC008121.13, AC023831.3, AC019255.2, AP000846.1, AL353691.2, AL158153.2, AC022156.4, AC016701.2, AC016525.3, AL161756.1, AL139396.1, AC008158.3, AC068786.4, AC009021.3, AC010503.5, AC008614.4, AC009120.5, AC027394.2, AL353622.3, AC064835.3, ACOl 1445.4, APOOl 187.1, AL354760.1. AC012635.1, SEQ ID NO. 174 NGO-Br-59 MK337/T3 5'

X56687.1, M61725.1, NM_014233.1, X53461.1, X53390.1, W2571.1, M61726.1, NM_0U551.1, X60831.1, L42570.1, M61724.1, AC004596.1, U65487.1, AF241726.1, X59863.1, X57201.1, X57561.1, X65698.1, X65697.1, AF164119.1, AF102773.1, AL078477.5, AC010083.5, AC018765.4, AF157625.1, AC006254.10, U78553.1, AC002986.1, AE000747.1, AE000803.1, AL353815.2, AL163290.2, U49246.1, AL049659.2, AL163812.1, ALl 17200.2, Z83125.1, Y09788.2, L20418.1, U41548.1, AP001745.1, AP001618.1, X73942.1, AB014538.1, AA683270.1, AI990923.1, AI652105.1, W56216.1, AI424653.1, AI361257.1, AW373605.1, AI263742.1, W28568.1, AA134165.1, AW867502.1, AI407688.1, AV098625.1, AW607456.1, AI121071.1, AA322474.1, AA494480.1, AA254648.1, AW362484.1, AA306865.1, AI947817.1, AV207877.1, AV140171.1, AV122483.1, AI594085.1, AI551499.1, AI463712.1, C85526.1, AA606502.1, AV083972.1, AI267702.1, AV392783.1, AV392203.1, AV392190.1, AV392165.1, AV387615.1, F15738.2, AI047080.1, C65313.1, AA437706.1, ACOl 1606.6, AC060757.2, AC021999.2, AC020754.2, ACOl 1606.5, AC024234.4, AC024899.4, AL158052.2, AC068918.2, AC026801.2, AC008795.5, AC008855.4, ACOl 1145.3, AC023857.2, AC007555.1, AL137780.2, AL138811.1, AC016955.9, AC012522.7, ACOl 1318.8, AC024891.8, AC061979.2, AC025638.3, AC037426.2, AC034103.4, AC062039.1, AC009237.2, AC021015.3, AC023582.2, AC040893.1, AC019008.4, AC019250.3, AC015801.3, AC013713.4, AC024253.2, AC022302.3, AC025598.1, AC022609.2, AC019251.2, AC024119.1, ACOl 6490.2, AC012499.3, AC018665.2, AC012340.2, AC009408.2, AL049715.21, AL157875.4, AL355535.1, AL355506.1, AL162582.2, AL162372.3, AL161615.2, AL136447.4, AP001769.1, AP000941.2, AP000869.1,. AP000846.1. AP000827.1,

SEQ ID NO.175

NGO-Br-59

MK337/T7 3'

NM_014233.1, X53461.1, X53390.1, X56687.1, NM_011551.1, X60831.1, AC004596.1, U65487.1, 2571.1_> L42570.1, M61725.1, M61726.1, X56688.1, AF241726.1, AF170811.1, AC007372.4, AC004912.1, AC007011.1, AC005295.1, AL132896.1, AL049837.4, AJ009934.1, AC004983.2, NM_014771.1, AC005782.1, AL121934.15, AB040880.1, AK000425.1, AK000265.1, AP000696.1, AB014561.1, AW373933.1, AW373896.1, AA626575.1, AA374794.1, AI915777.1, AI798277.1, AI521078.1, AI087037.1, AW249403.1, W31280.1, AA651656.1, R36455.1, AA919770.1, AA664208.1, AA329246.1, R36454.1, AA134166.1, AA961221.1, AA914265.1, AA911482.1, D56068.1, D56028.1, AI907998.1, AA623692.1, AA413864.1, AA308880.1, AI740529.1, AA637361.1, AW793731.1, AA889124.1,

AA377594.1, AI907995.1, AA377898.1, AA438075.1, AA211953.1, W83843.1, AI762169.1, AA611296.1, AW519549.1, AW390831.1, AI893975.1 , AA500491.1 , AA492907.1 , W80099.1 , W77364.1 , W33457.1 , Al 105117.1 , AA518740.1 , AW814069.1, AW814073.1, AI154308.1, AW438655.1, AW298403.1, AW243881.1, AW166393.1, AW001988.1, AI989406.1 , AI971828.1 , AI831668.1 , AI208785.1 , A1077671.1, AI027548.1 , AA890545.1 , AA768775.1 , AA577311.1 , AA056073.1, AA022622.1, AA021002.1, AA020748.1, AA019643.1, AA013126.1, H84980.1, H85537.1, AW819846.1, AW556048.1, AW433907.1, AI968114.1, AI678953.1, AI651215.1, AI202697.1, AA220802.1, AWl 96586.1, AWl 75973.1 , AI513981.1 , AI348282.1 , AI297541.1 , AI257079.1 , Al 187754.1 , AA973975.1 , AA942224.1 , AA816918.1 , AA478079.1, AA126812.1, H39217.1, AAl 83999.1, W79356.1, ACOl 1606.6, AC060757.2, AC021999.2, AC020754.2, ACOl 1606.5, AC009237.2, AC017099.3, AP001769.1, AP000827.1, AL162372.3, AC024234.4, AC021987.2, AP000668.1, AC026803.2, AC008749.4, AC026930.2, AC026285.4, AC018761.4, AC023154.4, AC012482.3, ACOl 1200.2, AL353609.2, AL139423.4, AL161662.1, AC010189.4, AC007834.20, AC053546.3, AC007339.3, AC022197.3, AC015867.2, AC022783.2, AC000005.1, AC020968.1, AL355293.2,

SEQ ID NO.176 NGO-Br-62 MK804/T3 5'

NM_005134.1 , AF 11 1106.1 , AC007736.3, AC008168.3, NM_013658.1 , AC005324.1 , X85991.1, AC004539.1 , NM_009134.1 , AC006287.1, AF075627.1 , ALl 22020.3, U58743.1, Y09108.1 , AC009486.3, AE003769.1, AC004888.1 , AC005013.1, AC007463.3, AC008067.3, AF189157.1, AE001980.1 , AC009888.1, AC005549.1, AL008733.10, Z68760.2, L46672.1, X94768.1, AP001278.1, AP000816.1, M2441 1.1, Z99105.1, AB006424.1, AW673704.1, AW371829.1 , AW382321.1, AW371827.1, AI081867.1₎ AW382320.1, AW371825.1, AI687366.1, AL120881.1, N41948.1, AW239384.1, AI286014.1, N40656.1, AW382480.1, AA161066.1 , AW367894.1, AA332078.1, AW382482.1, AW659290.1 , AW500241.1 , AA611470.1, AW392387.1, AA906014.1 , AW535590.1, AW534364.1, AW533907.1, AW534600.1, AW535963.1, AI552086.1, AW535977.1, AW535929.1, AW535612.1, AW535599.1, AW535574.1, AW535542.1, AW535538.1, AW535507.1, AW535217.1, AW534451.1, AW534434.1, AW534374.1, AW534356.1 , AW534229.1, AW534224.1, AW534199.1, AW534112.1, AW534076.1, AW534005.1, AW533992.1, AW533915.1, AW532274.1 , AW532226.1, AW532183.1 , AW532169.1, A W531827.1 , AW531069.1, AW530797.1, AW530120.1, AW530107.1, AW529979.1, AW529973.1, AW254242.1, AW254201.1, AW251947.1, AW251307.1, AW251102.1, AI709485.1, AI578408.1, AI555305.1, AI549564.1, AI549513.1, AI549263.1, AI549090.1, AI548886.1 , AI548373.1 , AI548339.1 , AI547780.1, AI547618.1, AI547615.1, AI535377.1, AI535100.1, AI535055.1 , AI535053.1, AI51 1474.1, AI501242.1, AA900666.1, AI137299.1, AI072600.1, AI072263.1, AI072230.1, AI071899.1, AI071691.1, AI071396.1, AI071193.1, AI071165.1, AI070019.1, AI058437.1, AI045860.1, AI045612.1, AI044996.1, AC021927.3, AP001381.1, AC015956.3, AC007140.1, AC026964.2, AC018989.3, AC024046.2, AC012596.3, AC009574.3, AC021114.3, AC018940.4, AC022971.2, ACOl 1172.4, AC016068.2,

SEQ ID NO.177 NGO-Br-62 MK804/T7 3' AF100744.1, U79267.1, NM_005134.1, AFl 11 106.1, AE003449.1, AL163301.2, NM_000236.1, AC016041.5, M29193.1, AL035653.12, AL023807.6, Z84475.1, J03895.1 , M35432.1, J03540.1, X07228.1, D83548.1, AC010102.3, AC006283.5, AE003514.1, AE003440.1, AC005690.8, AC006465.2, AC008075.2, AF101438.1, AL163302.2, AL163254.2, AL163233.2, AL136018.2, AL133097.1, AL109627.18, Z76735.1, AP001709.1, AP001688.1 , U23442.1, AP000950.2, AP000204.1, AP000244.1, AP000126.1 , AI076775.1 , AI215696.1, AI601253.1, AA581865.1, AI371049.1, H97837.1, AI131196.1, AI184641.1, AI754673.1, AI139064.1, AI142447.1, AI374783.1 , AI204302.1, AA772102.1, AA435767.1, AI659941.1, AA860292.1, AI569647.1, AA706309.1, AA732402.1 , AA706694.1 , AA192742.1, N56938.1, AA766582.1, AA171536.1 , N59159.1, A1336886.1, N49858.1, AA994358.1 , AI191899.1, N47550.1, AA074753.1, N30433.1, AA536150.1, AI348314.1, AI342660.1, N29328.1, AA401497.1, AA854769.1 _> AI220586.1, AI025515.1, AA9361 14.1, AA825278.1 , AA492553.1 , N77882.1 , AA804953.1 , AW068965.1 , AA860331.1, N89882.1 , AA769019.1 , N47895.1 , N63879.1 , Z39560.1 , AA805421.1 , W73239.1 , N66463.1 , T62952.1 , AI093651.1, AW839754.1 , R68907.1 , W57588.1 , AI970730.1, W92205.1, AA602432.1, F10765.1, AA074836.1, R22227.1 , AA255616.1 , AA987948.1, F03184.1, AA852934.1, H04250.1, R42968.1, AW503224.1, R67269.1, AI621152.1, AI536774.1, AW503670.1, H83900.1, AI743459.1, AW439253.1, AI571914.1, T92192.1, AW264100.1, AW172934.1, F04772.1, AI588862.1, H56904.1, R40975.1, AI915335.1, AW467646.1, AI678364.1, R43639.1 , AI625453.1 , AA643894.1, AI560721.1, R00485.1, W73294.1, AW270022.1, AA397947.1, AC015956.3, AC021927.3, AP001381.1, AL121900.7, AL121780.3, AC026570.2, AL354706.2, AC046148.2, AC027566.1, AC008658.2, AC015405.1, AL133499.1, AC016956.6, AC024153.10, AC008019.37, AC027489.2, AC016994.3, AC025130.2, AC016956.5, AL356377.1, AL121759.19, AL162381.3, ALl 39094.5, AC068908.2, AC069028.4, AC023057.6, AC012117.3, AC046161.2, ACOl 0631.4, AC0091 18.6, AC021471.2, AC009639.3, AC026967.2, AC027067.2, AC027059.2, AC026505.3, AC022050.2, AC019334.3, AC016910.2, AC012585.4, AC009384.5, AC012071.3, AC017069.3, AC012855.1, AC015230.1, AL356140.3, AL353578.2, AL158146.2, AL160057.4, AL162759.1, AL136975.1, AP001392.1,

SEQ ID NO.178 NGO-Br-63 MK467/T3 5'

NM_014731.1, ABOl 1124.1, AF123659.1, AF123658.1, AF123657.1, AF123656.1 , AF123655.1, AF123653.1, AL133215.16, AE0035O6.1 , NM_003980.1, AJ242502.1, AJ242501.1, AL023284.1, X73882.1, AF130782.1, AF190465.1 , AC006544.19, AC005033.1, AC003065.1, AC006985.2, U84269.1, U84268.1, AC003047.1 , AL031295.1, AE001862.1, U51197.1, AC004231.1, AP000279.1, AB004043.1, AB004042.1 , AB002339.1, AW416906.1, D56085.1, AW263065.1, AJ281091.1, AI911142.1, AI501468.1, W45377.1, AW530214.1, AW140903.1, AA819761.1, AI293560.1, AI230840.1, AA799815.1, C25135.1, AA086491.1, AW727488.1, AW657062.1, AW648093.1, AW581571.1, AW576745.1, AV306266.1, AW138828.1, AW045957.1, AI892415.1, AV014939.1, AI325725.1, AI069094.1, AA727234.1, AA400580.1, AL121891.18, AC025853.2, AC012162.9, AC012693.1, AC009216.8, ACOl 1498.4, AC017241.1, AC027118.2, AC026497.1 , AC009850.9, AC014014.1, AC017674.1, AC012600.4, AC012515.11, AC010189.4, AC008129.10, AC007834.20, AC023501.7, AC012293.9, AC044820.2, AC068126.2, AC068588.1, AC068557.1 , AC027764.2, AC062037.2, AC024948.2, AC055811.1, AC024474.2, AC021467.2, AC027267.1, AC026244.1, AC010121.6, AC015867.2, AC016439.4, AC016753.4, ACOl 1575.3, AC012600.3, AC013934.1, AC013499.2, ACOl 1135.2, AL138753.3, AL136990.14, AL136439.2, AL138757.4, AL137025.2, AL138955.1, AL136104.3, AL022335.6, APOO 1979.1, SEQ ID N0.179 NGO-Br-63 MK467/T7 3' NM_014731.1, ABOl 1124.1, AC019209.3, AC005829.1, AF045453.1, AL135999.2, AL132719.2, Z98946.15, AL021326.1, AC010385.3, AC007115.1, AC002477.1, NM_012654.1, AF179633.1, AL121809.4, AL035460.15, M85300.1, D14905.1, D14904.1 , AW134487.1, AW005916.1, AI918105.1 , AI369140.1, AI362807.1 , AI536952.1, AA233070.1, AI800560.1, AI570845.1, AI0841 11.1, AI805727.1 , AI566887.1, AI885796.1, AW205146.1, AA631005.1, AW088686.1, Z38359.1 , AI570882.1, AI889744.1, F03249.1, T23438.1, AI093242.1, AI151303.1, H64737.1 , T91286.1, AA682753.1, AW057576.1, AW752274.1, AA577015.1, AA319634.1, H65227.1, AW246038.1, AA862950.1 , AI573262.1 , AA639497.1, AI148651.1, AI129016.1, R44479.1, AW874175.1, AI849112.1, AAl 18865.1, W53946.1, AW611372.1 , AW359586.1, W96834.1, AA339527.1, AA320970.1, AA317924.1 , AW523114.1, AI229250.1, AI229142.1 , AA943809.1, AW658594.1, AW655764.1, AW426231.1, AW359271.1, AI863241.1, AI007273.1, AA832546.1, AA619805.1, AA571164.1, AA422555.1, AA260212.1, AA259669.1, AA240477.1, W16289.1 , H51681.1, AL121891.18, AC008133.2, AC021420.3, AC025898.2, AC009608.2, AC024225.8, AC024224.6, AC025194.2, AC016018.7, AL355482.1 , AC024105.7, AC023504.4, AC064837.2, AC025772.3, AC012636.3, AC034138.2, AC021355.3, AC027688.2, AC023819.3, AC015478.3, AC016868.4, AC009962.3, AC012505.3, AL354652.3, AL355884.2, AC009453.7, AC046135.4, AC068633.3, AC026084.2, AC026285.4, AC026792.2, ACOl 1356.3, AC024230.3, AC024537.2, AC027216.2, AC027526.2, AC026423.3, AC027685.2, AC015928.4, ACOl 1033.3, ACOl 1957.2, AC016180.5, ACOl 1213.4, AC023920.2, AC016483.6, AC023291.2, AC005052.1, AL356154.2, AL355590.2, AL354726.2, AL355476.1, AL353589.1, AL157375.1, AP001855.1, AP000752.1, AP000721.1,

SEQ ID NO.180 NGO-Br-64 MK731/T3 5'

NM_014963.1, AB023180.1, AC005390.1, AF060974.1 , AC007246.3, AL049754.1, AEOO 1274.1 , A J242840.1, AJ242839.1, Y15791.1 , AE003835.1, AE003596.1, AC005290.3, AFl 17761.1, AFl 17760.1, NM_000506.2, AC007655.1, U73167.1 , U90094.1, M24461.1 , ALl 33224.2, AL121756.14, U50596.1, U00012.1, AL022374.1, X82071.1, AB001030.1, V00595.1, J00307.1 , M33031.1, D17389.1, X54794.1, M60789.1 , Y 10403.1, AW410223.1, AW468990.1, AI827893.1, AW081199.1, AA977476.1, AL045506.1, AL079747.1, AW206971.1, AW073064.1, AI559848.1, AI760801.1, AI430503.1, AA245512.1, AA245370.1 , W62920.1, AW729115.1, AW668796.1, AW431830.1, AW348976.1, AW64981 1.1, AW623969.1, AW056157.1, AI987383.1, AI941796.1, AI896465.1, AI691275.1, AI670672.1 , AI465663.1, AI456906.1, AI397644.1, AI054620.1, AA855993.1, C32683.1, AA354150.1, AA334812.1, AA286992.1, H69659.1, H59101.1, ACOl 1474.2, AC020781.4, AC020582.3, AC068633.3, AC032027.2, AC048370.2, AC012334.2, AC008713.5, AC016573.4, AC025868.2, AC023826.2, AC018445.3, AC019356.3, AC027817.1, AC012286.2, AC007524.2, AC026086.2, AC023356.4, ACOl 1951.3, AC015930.3, AC012568.3, AC012374.9, AC024610.1, AC01001 1.3, AC012454.3, AC013279.3, AC013750.4, AC020372.1, AC013563.2, AC017853.1, AC007471.3, AC007597.2, AC007503.1, AL356138.3, AL138720.5, AL137162.5, AL137225.1 1, AL162499.3, AP001337.1, SEQ ID N0.181 NGO-Br-64 MK731/T7 3')

AC005390.1, NMJH4963.1, AB023180.1, AC002351.1, Z82215.1, AE003544.1, NM KM474.1, NM_000758.1, AC005950.1, U37501.1, AF042832.1, AC00451 1.1, AC003675.1, AL163299.2, AC001228.1 , AL050318.12, Z85994.1, AJ006345.1, M13207.1, AP001754.1, AP001062.1, X03021.1, Ml 1220.1, M10663.1, M28860.1 , M28859.1, AC068783.2, AE002501.1, AC007537.3, AC005261.1, AL162756.2, AL122127.3, X97051.1, X17215.1, X57133.1, X16489.1, U18978.1 , AB019441.1, X13972.1, M37277.1, AI200815.1, AI417909.1 , AI459189.1, AI560887.1, AW270083.1, AI564758.1, AI745070.1, AI355293.1 , AI815176.1, AL047897.1, AL047898.1, AW474741.1, AI469279.1, AI359252.1, AA722975.1, AA444008.1, AI220310.1, AI624704.1, AI289062.1, AI623674.1, AL045507.2, AA456471.1, Z25344.1, AA444037.1 , AA427461.1, R96945.1 , AW472864.1 , AA654248.1 , AA456804.1 , AA427462.1 , AA954685.1 , AI932512.1 , AA485597.1, AI433817.1, AA485433.1 , AA454577.1, AA457134.1, T30158.1, AA476273.1, AW138346.1, AA464482.1, T95376.1, T95296.1, AA299621.1, AA293227.1, AI866076.1, AI801586.1, AA884991.1, AA435961.1, AW013846.1, AW410224.1, AI391545.1, AA971658.1, AA932895.1, AW431713.1, AW547208.1, AW345308.1, AI085206.1, AI022933.1, AI912784.1, AI677936.1, AI655452.1, AA096946.1, T29160.1 , AW749596.1, AW213795.1, AW207707.1 , AW005369.1, AV131761.1, AV062291.1, AI695173.1, AI524311.1, AI508690.1, AI462638.1, AI417791.1, AI232789.1, AI072326.1, AA288479.1 , AA135536.1, W73276.1, W03892.1, D51085.1, T33074.1 , AL162423.2, AC016525.3, AC018930.3, AC010033.7, AC034216.3, AC026699.2, AC009175.3, AC010590.4, ACOl 1361.3, AC021424.3, AC013791.3, ACOl 1182.3, AC018891.2, AC009899.5, AC023171.1, AC022754.1, AC013287.6, AC016743.3, AC021389.1, AC014953.1 , AC003656.1, AP001356.1, AC016968.1 1, AC015545.10, AC024097.8, AC022296.8, AC037471.2, AC025468.3, AC025460.3, AC024075.3, AC010378.3, AC008681.5, AC024293.2, AC023484.2, AC021328.3, AC019345.3, AC022051.3, AC018427.3, AC021200.4, ACOl 1281.3, AC027171.1, AC024951.9, AC021585.3, AC017096.2, ACOl 1 140.3, AC009575.4, AC016968.10, AC015545.9, AC016757.3, AC010136.3, AC013567.2, AC009647.2, AC010782.1 , AL035662.50, AL136079.3, AL157939.3, AL158817.2, AL158143.1, SEQ ID NO.182 NGO-Br-65 MK385/T3 5'

AF086824.1, U39904.1, AF039218.1, AF070066.1, AC004811.2, AC002563.1, NM H5239.1, AK00I544.1, AC007023.3, AC007078.3, AC000039.3, AC006480.3, AC005488.2, AC005088.2, AF030453.1, ALl 21823.12, ALl 61571.2,

AL022326.1, AL078579.1, L09233.1, AE003628.1, AC005537.2, AC005036.1, AC007038.3, AC007451.1, AC006254.10, AF063424.1, AF092090.1, AC005359.1, AC000378.1, AL161513.2, AL035703.20, Z75543.1, AL035681.13, Z93020.1, X59046.1 , X65624.1 , AB037724.1 , M22462.1 , AW449442.1 , A W444459.1 , AI826767.1 , AI674481.1, AA570498.1 , H62116.1, AW760341.1, AW733957.1, AW598733.1, AW459885.1, AU082470.1, AV403875.1, AW325533.1, AW325530.1, AWl 62177.1, AW149411.1, AW076876.1, AW076660.1, AI924223.1, AI510359.1, AA968035.1,

AA508904.1, AA508038.1, AA236748.1, AA177241.1, AA140828.1, AAl 16487.1, AA107365.1, W62286.1, H16776.1, T18197.1, AC026363.3, AC026765.5, AL157828.5, AC012032.1 1, AC023923.2, AL159156.4, AL157362.2, AC019315.2, AL139429.4, AC019071.3, AC025232.3, AC023593.3, AC018720.3, AC012406.3, AC023811.7, AC005236.3, AC004980.2, AC007674.2, AC026507.1, AC016294.2, AC022253.2, AL139182.14, AL137118.8, AL162387.3, AL161642.3, AL049770.1, APOOl 809.1, AC009774.4, AC021064.7, AC024505.3, AC023493.6, AC026418.2, AC024991.2, AC068482.1, AC027104.2, AC023170.3, AC019063.3, AC019043.3, AC027184.2, AC058808.1, AC026043.3, AC018513.3, AC026002.2, AC019356.3, AC016875.3, ACOl 1952.4, AC009933.5, AC020796.2, AC018887.4, AC022245.3, AC016513.2, ACOl 1009.4, AC022182.3, AC012306.3, AC016245.3, AC020201.1, AC016521.1, AF162757.1, AL133268.6, AL121955.9, AL136114.2, AL136159.4, AL353762.3, AL354720.3, AL355526.2, AL161908.3, AL160400.3, AL138896.2, AL137838.2, AL133167.1, AL138689.1,

SEQ ID NO.183 NGO-Br-65 MK385/T73' AC002563.1 , AB023166.1 , U75698.1 , U93872.1 , AP000542.1 , AE003597.1 , AC004506.1 , AC004695.1 , AL049781.4, AL034404.1, X58358.1, AP001819.1, AI861788.1, H10788.1, AW386741.1, AW581596.1, AW386738.1, AA308642.1, N57796.1, AI933041.1, AI984971.1, T91324.1, W42440.1, AI933217.1, N57810.1, AI933106.1, R50756.1, R44891.1, H79564.1, H63135.1, AA353105.1, AA224531.1, AI861826.1, AI245941.1, AW054833.1, AA778789.1, AI806134.1, AW483290.1, AW416772.1, AI936328.1, AA379967.1, AA677294.1, AW047976.1, AW047308.1, AW046893.1, AA617920.1, AA546601.1, AW046868.1, AA822334.1, W78614.1, AI183534.1, AW525869.1, AW665288.1,

AA957183.1, AI807388.1, AI228556.1, AI698168.1, AI102448.1, AA955912.1, AI017868.1, AI767064.1, AW797442.1, AW859870.1, AW248416.1, AWl 17872.1, AC026363.3, AC023264.2, AC069045.1, AC027398.2, AC009268.2, AC024485.2, AC022188.3, AC024111.6, ACOl 1138.2, AC024217.6, AC022132.4, AC024927.2, AC023641.2, AC034147.4, AC013447.3, AC025690.3, AC019311.4, AC023974.2, AC023205.2, AC022460.2, ACOl 8349.2, AC017535.1, AC010689.2, AC004064.1, AL118502.34, AL139241.4, AL138693.6, AL161939.2, AL157716.2, AC001235.1, AP000452.2, AP001833.1,

SEQ ID NO.184 NGO-Br-66 MK805 T3 5'

U73200.1, AB000214.1, AC003080.1, AC002395.1, AC005244.1, Z68279.1, AC007327.1, AC005817.7, AC007665.24, AC008266.3, AE003615.1, AE003580.1, NM_010559.1, AC004615.1, AF140707.1, NM_003688.1, AF130357.1, AC004893.1, AC005839.1, AFl 11102.1, AC005807.1, AC005855.1, U58494.1, AC005356.1, AC003052.1, AC005211.1, AC004598.1, Ml 7551.1, AF035582.1, AF032119.1, AJ403418.1, AF027865.I, X97915.1, AC002094.1, AJ290445.1, AL021127.2, AL080241.14, Z83844.5, AL031347.1, U70381.1, U70380.1, U26425.1, X51976.1, X98188.1, X01709.1,

X91192.1, AB029009.1, M27972.1, M18252.1, M36323.1, L35243.1, ABOl 1297.1, AB011096.1, U08129.1, AL048447.2, AA378192.1, AA312335.1, AW501959.1, AA675911.1, AA015476.1, AA220385.1, AA681477.1, AW321789.1, AW701965.1, AW171289.1, AW140423.1, AI618679.1, AI617588.1, AI545690.1, AI416377.1, AW727131.1, AI878211.1, AA867310.1, AW822989.1, AW822908.1, AW140419.1, AW107372.1, AI876330.1, AI876315.1, AI787888.1, AI673281.1, AI661565.1, AI647986.1, AI596598.1, AI593550.1, AI563647.1, AI448821.1, AI429489.1, AI416269.1, AI316550.1, AI286579.1, AI272572.1, AI272468.1, AI272432.1, AI265094.1, AI265081.1, AI265039.1, AI265016.1, AI227615.1, AI098293.1, AI097946.1, AU017425.1, AU016228.I, AU014817.1, AA983005.1, AA981167.1, AA930951.1, AA920957.1, AA920358.1, AA920053.1, AA919936.1, AA896813.1, AA896091.1, AA896033.1, AA896016.1, AA867305.1, AA797842.1, AA791920.1, AA734060.1, AA672803.1, AA656916.1, AA647396.1, AA561026.1, AA432827.1, AA415676.1, AA239702.1, AA197111.1, AAl 18415.1, AAl 04979.1, AAl 04928.1. AA045964.1,

AA014354.1, W38611.1, H93255.1, H89667.1, R15163.1, AC069071.2, AC018473.10, AC007775.2, AC025911.2, AC026386.4, AC024042.3, AC005805.1, AC002405.1, AC055890.2, AC021494.3, AC022701.1, AL355994.1, AL121750.3. AP000780.1, SEQ ID NO.185 NGO-Br-66 MK805/T73'

AB020671.1, D23673.1, D26154.1, U73200.1, AD001527.1, AC003003.1, AF048729.1, AL353012.1, AL096799.4, AJ011517.1, U66909.1, AE003569.1, AC007243.3, AC005071.2, NC_001224.1, AC007284.4, AC007514.5, AC002401.1, AF055066.1, AL163218.2, AJ011856.1, Z82195.1, AL031985.10, V00695.1, L36887.1 , AP000521.1 , AB023058.1, AC007040.2, AC005060.2, AC005353.1, Z98551.1, AL035475.6, AL031390.4, AC009233.3, AC020717.3, AF185568.1 , U82670.2, AE003491.1, AC004553.1, AC002540.1 , AF030694.2, AF214529.1, AC004992.1, AC004998.2, AC004999.1, AC007077.2, AC007402.3, AF006055.1, AC005081.2, AF052006.1, AC004814.2, AC006275.1, AE001368.1, AC000084.1 , AC005031.1, U80017.1, AF045555.1, AC003968.1 , AL033528.19, AL033385.1, AL034548.25,

AL121601.13, AL031 1 17.1, Z84486.1, Z93018.1, AL008734.10, Z84718.2, Z83841.1, Z92542.2, AL009181.1, U46165.1, AL008983.1 , L36890.1, AP000211.1, AP000150.1, AP000138.1, AP000563.1, AP000224.1 , AP000133.I, AP000086.1, AP000009.2, AB020863.1, AI742600.1 , AW409781.1, AA487042.1, AI570591.1, AI052677.1, AW189149.1, AA732243.1, AI342608.1, AA813983.1 , AI864433.1, AL121497.1, AI313170.1, AA535345.1, AI819339.1, AI140858.1, AA463855.1, AA622061.1 , AW071972.1, AI039825.1, AI739551.1, AI681889.1, N63033.1, AI916806.1, AI189978.1, AA812039.1,

AW009437.1, AI926737.1, AA551298.1, AA128822.1, AI222960.1, AI656010.1 , AI147461.1 , AI367859.1 , AA732922.1 , AI335920.1, AA405100.1 , AL039337.2, AA602783.1, AI138662.1, AI128055.1 , AI288513.1, AI192368.1, AA514278.1, AW009113.1, AI222961.1, AI929221.1, AA128823.1, W95443.1, AI804032.1, R53599.1, AA625309.1, AI308061.1 , AI308050.1, AA604594.1, AW393654.1, N68947.1, AI570799.1, AW021963.1, AW419279.1, N34337.1, AI681778.1, T70294.1, AA628356.1, AA040382.1, H66939.1, AA497027.1, AW816672.1, AI332322.1, AA758762.1, R83381.1, AA026077.1, AA349890.1, AI301205.1, AI825535.1, R92218.1, AA829906.1, AA626936.1 , W95788.1, AA861469.1, AI085101.1, AA576806.1, N51568.1, AA761610.1, AA040476.1, T77759.1, AA923625.1, AI090324.1, AA410392.1, R86315.1 , AI125301.1, AA911222.1, H44545.1, T47795.1, AW630895.1, AI039856.1 , AI344296.1 , AI978577.1, H42397.1, T77760.1, AA928570.1, AC007775.2, AC015847.1, AC069071.2, AC015849.2, AC018473.10, AC024725.2, AC024710.2, AC055811.1 , ACOl 1374.4, AC016098.3, AC005308.6, AC006286.13, AL354739.3, AL122018.22, AL162491.3, AC016928.10, AC02551 1.2, AC011461.2, AC005073.2, AC012198.3, AC019092.2, AC007926.6, AC007862.4, AC010999.2, AC015652.6, AC021574.3, AC025994.2, AC021786.2, AC025025.2, AC005140.6, AC004153.5, AC023441.2, AC020966.1, AC013409.3, AC005139.3, AL162417.1, AC036200.2, AC010397.5, AC008742.6, AC008813.4, AC027733.2, AC009977.3, AC026379.3, AC026549.2, AC024986.2, AC005505.6, AC015623.3, AC016071.2, AC005504.3, AC004710.3, AL122035.2, AP001392.1, AP001104.1, AC069126.1, AC005842.6, AC06911 1.1, AC013553.10, AC062030.2, AC027632.4, AC068850.1, AC022150.4, AC016586.4, AC022147.4, AC009143.4, AC027548.2, AC067898.1, AC016385.3, AC025481.2, AC025928.2, AC027272.2, AC027586.1, AC010787.3, AC024969.2, AC012428.4, AC017030.4, AC021305.3, AC025337.1, AC022928.1, AC018879.3, ACOl 1694.2, AL355385.4, AL109825.17, AL16191 1.3, AL157831.2, AL121747.21, AL109815.2, AL096782.3,

SEQ ID NO. 186 NGO-Br-67 MK495/T3 5' U13369.1, X13993.1, AA161421.1, AA214215.1, AA166833.1, AA166827.1, AA085249.1, AC025630.1, AC010554.1, ACOl 1630.2, AL355134.1, AL158197.6, AC026915.1, AC068881.1, AC023572.3, AC018688.4, AC064866.2, AC064825.3, AC010970.2,

SEQ ID NO. 187 NGO-Br-67 MK495/T7 3'

U20938.1 , NM_000110.2, U09178.1 , AB003063.1 , U20981.1 , U09179.1 , D85035.1 , U39742.1 , U56248.1 , AF220294.1 , AE003647.1, AE003413.1 , AE002206.1, AC007501.2, AC004535.1, AC004945.1, AC006977.3, AE001615.1, AC004962.1 , AC002981.1, AC002546.1 , AC002436.1 , AL050342.42, ALl 39074.2, U88171.1 , U39654.1 , AP000003.1 , AI752078.1, AI786904.1, AI746780.1, W49558.1, All 19026.1, W03174.1 , AW630700.1 , AI931647.1, AU076411.1, AW175385.1, AWl 74937.1 , D36086.1, AW829780.1, AW829729.1, AW829453.1, AW828679.1, AW828317.1, AW421789.1, AI765768.1, AW859693.1, AW531377.1, AV008918.1 , AI599543.1, AA926321.1, AA818512.1, AA891593.1, AA851914.1, AA886930.1, R04419.1, AL354881.3, AL162575.4, AC006448.10, AC008603.4, AL137159.1, AC008961.4, AC008561.3, AC021003.4, AL356266.2, AL133548.6, AP002006.1 , AC068969.1 , AC055784.2, AC036131.2, ACOl 1333.4, AC034128.2, AC009579.3, AC027374.2, AC060828.3, AC025091.3, AC067805.1, AC046147.2, AC027618.2, AC015953.3, AC024606.2, AC025821.2, AC016310.5, ACOl 1155.4, AC023814.2, AC023246.2, AC022206.2, AC025338.1, AC015567.3, AC019239.3, AC007490.3, AC019133.3, AC020173.1, AC006846.1, AL355493.2, AL355498.2, AL158210.6, AL356101.1 , AL353759.3, AL161740.4, AL139243.3, AL139244.2, AL138920.2, AL139000.2, AP001934.1, AP001484.1,

SEQ ID NO.188

NGO-Br-69

MK319/T3 5'

NM_007186.1, AF049105.1 , AL121586.28, AF022655.1, NM_008383.1, U33198.1, AE003526.1, AC006933.3, AC006486.1, U34932.1, AC004877.1 , AF072845.1, AC005602.1, AD000864.1, AD000833.1, L08845.1, AE003795.1, U94409.1, AI124555.1 , AWO60335.1, AA647911.1, W83246.1, AW732245.1, AW590218.1 , AW340426.1, AI989500.1, AI983119.1 , AI808699.1, AI654406.1, AI653050.1 , AI650974.1, AI638614.1, AI637922.1, AA977540.1, AW626159.1, AW622831.1, AW622685.1, AJ397298.1, AW504867.1, AW399321.1, AW405716.1, AW096606.1, AW094388.1 , AW094030.1 , AI912988.1 , AI886821.1, AI823876.1 , AI782590.1 , AI780656.1 , AI775035.1 , AI771616.1 , AI695784.1 , AI539054.1, AI488077.1 , AI486997.1, AI435874.1, AI391305.1, AI382942.1, AI288287.1, AI277512.1, D89319.1 , AA824970.1, AA824942.1, C23550.1, AA243659.1 , AA131248.1, AA130548.1, C01658.1, W18282.1, L44352.1, D51291.1, R51070.1, T23439.1 , AL139226.14, AC010751.3, AC010688.4, AC014935.1, AC010690.1 , AC023065.3, AC021858.2, AL158835.3, AL133230.20, AL353653.5, AL139330.5, AL135907.3, AL353609.2, AC069242.1, AC025177.3, AC025531.2, ACOl 1432.2, AC012277.2, AC023303.2, AL157888.2, AL139237.4,

SEQ ID NO.189 NGO-Br-69 MK319/T7 3' NM_007186.1 , AF049105.1, AL121586.28, AF022655.1, NM_008383.1, U33198.1, AC004691.1, AE003666.1,

AC002503.1, M34989.1, X14428.1, AE003817.1, AE003513.1, AC004931.1, AC005977.3, AC005245.1, AL163304.2, AJ004834.1, AL009174.1, AP001759.1, APOOl 101.1, X75910.1, NM_000449.1 , AF257304.1, AF257303.1, AC006533.7, AF206287.1, NM_009307.1, AC007463.3, AE001862.1, AF092918.1, AC003689.1, AC004134.1, AF020554.1, AL161540.2, AL161539.2, AL050135.1, U60780.1 , AL031686.2, Z97337.2, Z99122.1, U22062.1 , X80301.1, X85786.1, M86250.1 , D37793.1 , L03208.1 , D43752.1 , Z92952.1 , D85027.1 , AL037087.2, AI872306.1 , AI811998.1 , AI401068.1 ,

AA613882.1, AI687495.1 , AI224019.1, AA970425.1, AW083819.1 , AA595119.1, AW084657.1, AI817733.1 , AI419425.1, AI240622.1, R87989.1, AI204529.1, AI000880.1, AA848087.1, Z40915.1, AA502324.I, AW078517.1, AI699218.1, AA729465.1, T85911.1 , R88035.1, AW504249.1, AW133062.1, AW435751.1, AW346610.1, AI534994.1 , AI534415.1, AI530805.1, AI519460.1, AI512712.1, AI456969.1, AI455689.1, AI404669.1, AI388686.1, AI388197.1, AI388073.1, AI387697.1, AI387259.1, AI386601.1, AI192646.1, AI135562.1, AI135091.1 , AI107565.1, AI063523.1 , AI063307.1, AA942336.1, AA941421.1, AA201182.1 , AA392346.1, W82939.1 , AW784983.1, AW607628.1, AW454537.1, AW029340.1, AW024754.1, AI991341.1, AI937337.1, AI863172.1, AI717513.1, F28098.1, AI523953.1, AI343828.1, AI340266.1, AI032053.1, AI024499.1, AA991616.1, AA937835.1, AA889325.1, AA872357.1, AA812821.1, AA805252.1 , AA746136.1 , AA722399.1 , A A660763.1 , AA586676.1 , AA532648.1 , A A527348.1 , AA523469.1 , AA504479.1 , AA417368.1, AA405813.1, AA262932.1, AA228934.1, AA055130.1, N30852.1, H94195.1, D63281.1, R72540.1, AL139226.14, AL122019.21, AC027740.2, AC022067.2, AC021359.2, AC017441.1, AL162382.2, AP00049I.1 , AC010759.2, AC046181.1, AC026053.2, AC022262.3, AC024341.2, AC020964.1, AC015349.1, AC020328.1, AC010671.7, AF161326.1, AL162271.2, AC020923.4, AC008906.3, AC008790.4, ACOl 1459.2, AC009544.4, AC053476.1, AC019325.3, AC016841.2, ACOl 1568.3, AC009565.7, AC022047.4, AC021225.3, AC012354.3, AL162234.3, AL157949.2, AL138699.1, AP000451.2, AP001384.1 , APOOl 163.1, AP000666.1,

SEQ ID NO.190 NGO-Br-70 MK061 T3 5' Z36816.1, AC008469.4, U91320.1, AL117630.1, Z82205.1, Z50112.1 , X82322.1, AB018295.1, AF142100.1, AC008498.3, AE002153.1, AC004830.1, AC004738.1, Z78419.1, AL034397.1, X63598.1, L14017.1, Y13096.1, Y13095.1, X54660.1 , Y14051.1, D86934.1 , AB033763.2, L14020.1, AL046916.1, AW732487.1, AA088822.1 , H50443.1, T65364.1, AAl 12796.1, Fl 1994.1, R11879.1, AW414271.1, AW414220.1, AA075824.1, AA363903.1, AW786911.1, AA896188.1 , AW403711.1, H19785.1, AI197257.1, T65515.1, AW401567.1, AL047058.1, R55598.1, AW143393.1, AW375060.1, AI591958.1. F11904.1, AA742633.1, AA517314.1, W85360.1. T08516.1, AA184178.1, D28616.1, AA000364.1,

AW796180.1, AW401580.1, T16871.1, AA739011.1, AI153477.1, W21846.1, AW785749.1, AA053446.1, D21680.1, AW390748.1, AA032616.1, AW401807.1, AW801635.1, AA027649.1, Z45691.1, F08352.1, AI410833.1, AW557036.1, AA895817.1, AW546958.1, AW575180.1, AW640041.1, AW555199.1, AJ397620.1, AA018126.1 , AJ397023.1, R09436.1, AW522370.1, AJ395743.1, AJ392332.1 , AW269432.1, AW169948.1, AI914378.1 , AL046089.1, AV106169.1, AI371352.1, AA922035.1 , AA707531.1, N91137.1, R45445.1, AW815118.1, AW163019.1 , AI522333.1, AA965117.1, AA317592.1, H10898.1, R16064.1 , AC023861.2, AC025415.3, AC067823.2, AC026400.2, AC008785.3, AC020710.4, AC024452.2, AC026821.2, AC021956.3, AC023442.2, AL355499.5, AC023449.3, AC036143.2, AC025544.3, ACOl 1509.5, AC008691.4, AC023020.3, AC048481.1 , AC024053.2, AC008703.3, AC027678.1, AC023812.3, AC015900.2, AC009637.3, AC025221.2, AC025565.2, AC019141.3, AC018421.3, AC021603.2, AC023380.1, AC022390.1, AL356215.1, AL355972.2, AL139276.2, AL136989.4, AL161742.3, AL353713.1, AL158204.2, AL158143.1, ALl 37845.1,

SEQ ID NO.191 NGO-Br-70 MK061/T7 3'

AF035296.1, AC010889.2, AF038149.1 , Z70685.1, AE003463.1, AC006317.3, AF200688.1, AC008041.5, AC005684.1, AC004601.1, ALl 33451.1, AL050347.1 , X55146.1, Z73987.1 , A W471383.1, AW294879.1, AI827389.1 , AI433239.1 , AW575180.1, AW574507.1 , AI936491.1, AI803377.1, AW575276.1 , AW574501.1, AW574595.1, AW081903.1, AI017541.1 , AW575023.1, AW474843.1, AW269983.1, AI143057.1, AW662466.1, AW149715.1 , AI818173.1, AW027629.1, AI129967.1, AI084109.1, AA629401.1, AI032340.1, AA775878.1, AI734859.1, AI688609.1, AA1341 14.1, AA088684.1, AI537873.1, AW474193.1, AA709474.1 , AW087318.1, AA052969.1, T17399.1, AW244157.1, AI198524.1, AA455953.1, AA662286.1, T65434.1, N23103.1, AI500354.1 , T77285.1, R48306.1, T87060.1, AW079744.1, T16870.1, AA242771.1, AA364661.1, AA725410.1, AA888835.1, AWl 83474.1, R48408.1, R55361.1, AI952437.1, AI383126.1, AA772585.1, R17756.1, R53154.1, AI468078.1, T83615.1, AA740428.1, AA989632.1, AA776777.1, AW088969.1, AA970686.1, AW467672.1 , F09551.1 , R84473.1, AA053446.1, AW839837.1, AW801635.1, R40543.1, AA242901.1 , AW375060.1, W21846.1, AW295371.1, AA485133.1, AA281393.1, AW834883.1, AW426950.1 , AW335961.1, AI953843.1, AI935134.1, AI817633.1, AI808163.1, AA924764.1 , AI370430.1 , AA232269.1, AA224090.1, AP001028.3, AC003094.1, AC025920.8, AC024162.2, AC021006.3, AC020773.3, AC026197.1, AC026181.1, AC020755.2, AC024159.1, AC068063.2, AC026416.2, AC020942.4, AC067757.1, AC008162.2, AC046179.1 , AC027654.1, AC019099.3, AC024944.2, AC016453.4, AC013350.6, AC024511.2, AC013816.3, AC023176.3, AC016525.3, AC024911.1, AC023157.4, AC010734.3, AC012167.4, AC008131.11, AC020499.1, AC017700.1, AC006100.1, AL356370.1 , ALl 18519.20, AL138762.5, AL137853.7, AL133388.3, AL354680.4, AL160157.3, AL138848.3, AL353733.1, AL162430.1, AL157826.2, ,

SEQ ID NO.192

NGO-Br-70

MK231/T3 5'

Z36816.1, AC006075.1, Z54328.1, AC008469.4, U91320.1, AC003034.1, AF165142.1, AC004987.2, AL137290.1 , AL117630.1, Z83849.1, Z93242.1, Z82205.1, Z501 12.1, X82322.1, AB018295.1, AF142100.1, AC005137.1, AE002153.1 , U89337.1, AC005940.3, AC004738.1, AE000895.1, AL163229.2, AL034397.1, X63598.1, L14017.1, Y13096.1, Y13095.1, X54660.1, Y14051.1, AP001684.1, D86934.1, AB033763.2, AP000705.2, Y11769.1 , L 14020.1. AL046916.1, AW732487.1, H50443.1, AA088822.1, T65364.1, AAl 12796.1, F11994.1, Rl 1879.1, AA075824.1, AW40371 1.1, T65515.1, AW414271.1, AW414220.1, AW786911.1, AA363903.1, AA896188.1, AW401567.1, AL047058.1, R55598.1, H19785.1, AI197257.1, Fl 1904.1, AW143393.1 , AW401580.1, AW796180.1, AA517314.1, W85360.1, AA742633.1, AI591958.1, T08516.1, AW375060.1, AW401807.1, AA184178.1, D28616.1, AA000364.1, T16871.1, F08352.1, Z45691.1, AW785749.1, D21680.1, AW390748.1, AA739011.1, AI153477.1, AA032616.1, AA027649.1, AA018126.1 , AW403200.1 , AW402516.1 , W21846.1 , AA053446.1 , AW402128.1 , AI410833.1 , AW557036.1 , AA895817.1 , AW546958.1 , AW640041.1 , AW555199.1 , AJ397620.1 , AI254622.1 , T31811.1 , AJ397023.1 , AJ395743.1 , AJ392332.1 , AW269432.1, AWl 69948.1, AI914378.1, AL046089.1, AV106169.1, AI371352.1, AA922035.1, AA707531.1, N91137.1 , R45445.1, AW815118.1, AW163019.1, AI592661.1, AI522333.1, AI341327.1, AA317592.1₎ AA184644.1, H10898.1, R16064.1, AC027678.1, AC022390.1, AC023861.2, AC011591.4, AC027683.1, AC015844.4, AC015875.1, AL157397.2, AP001926.1, AP001284.1, AP000764.1, AP000614.3, AC025415.3, AC067823.2, AC019331.3, AC026400.2, AC010324.4, AC020710.4, AC022916.2, AC024452.2, AC027437.2, AC027069.2, AC026008.2, AC022696.3, AC021956.3, AC023954.2, AC023442.2, AC023241.2, AL355860.1,

SEQ ID NO.193 NGO-Br-70 MK464/T3 5' Z36816.1 , AK000595.1, Z54328.1, AC006960.1, AC007540.3, Z82205.1, Z50112.1 , X82322.1, AF142100.1, AC002380.1, AE002153.1, AC004738.1, AC005371.1 , AJ251829.1, Z85996.1, AL034397.1, X63598.1, L14017.1, Y13096.1, Y13095.1 , X54660.1, Y14051.1, D86934.1 , AB033763.2, L14020.1, AL046916.1, AA075824.1, AW403711.1, H50443.1, T65364.1, AW401567.1, T65515.1, AL047058.1, R55598.1, F11904.1, Fl 1994.1 , AW401580.1. AW796180.1 , AW732487.1, A W401807.1 , AA088822.1 , Z45691.1, AW786911.1 , Al 197257.1 , AA896188.1 , AW403200.1 , AW402516.1 , AA018126.1. R11879.1, T16871.1. T08516.1, AA517314.1, W85360.1. H19785.1, AAl 12796.1, T31811.1, AW414220.1, AW405526.1, AW414271.1, AW143393.1, AA363903.1, AW402128.1, AA027649.1, AA742633.1 , AW785749.1, AI592661.1, F08352.1, AI591958.1, D21680.1, AW390748.1 , AW402023.1, AA184644.1, AA184178.1, D76728.1, D28616.1, AA000364.1, AW640041.1, AJ397620.1, AJ397023.1 , AV106169.1, AW815118.1 , AW163019.1, AW159142.1, AW159141.1, AW159140.1 , AW158139.1, AW158059.1, AI657929.1, AA317592.1, H10898.1, R16064.1, AC023861.2, AC025415.3, AC067823.2, AC020710.4, AC024452.2, ACOl 1052.4, AC021956.3, AC023442.2,

SEQ ID NO.194 NGO-Br-70 MK464/T7 3' AF035296.1, AE003725.1, AC007053.15, U96104.1, U58920.1, AF038149.1, Z70685.1, D87992.1, AC006317.3,

AC008041.5, AC005684.1, AC004601.1 , AL133451.1, AL050347.1, X55146.1, Z73987.1 , AW575180.1 , AA775878.1, AW575276.1, AW574595.1, AW575023.1, AW574501.1, AW574507.1, AW294879.1, AI827389.1, AA629401.1, AW471383.1, AI433239.1, AI936491.1, AI803377.1, AW149715.1, AW081903.1, AI017541.1, AW474843.1, AW269983.1, AW027629.1, AI143057.1, AW662466.1, AI818173.1, AI129967.1, AI084109.1, AI032340.1, AI734859.1, AI688609.1, AA1341 14.1, AA088684.1, AI537873.1, AW474193.1 , AA709474.1, AW087318.1, AA052969.1, T77285.1 , T17399.1, AW244157.1 , R53154.1, AI198524.1, AA455953.1, AA662286.1 , R48408.1, N23103.1, T65434.1 , AI500354.1, AA053446.1, AW801635.1, AW079744.1, R48306.1, T16870.1, T87060.1, AA364661.1, T83615.1, AA242771.1 , AA725410.1, AA888835.1, AWl 83474.1 , AI952437.1, AI383126.1, R55361.1, AA772585.1, AW839837.1, R17756.1, AI468078.1 , AW375060.1 , AW088969.1 , AA740428.1 , AA989632.1 , AA776777.1 , W21846.1 , AA970686.1 , F09551.1, AW467672.1, R84473.1, AA242901.1, D30911.1, R40543.1, AW479983.1 , AW834883.1, AW826181.1, AV417825.1 , AW557036.1, AW555199.1, AW546958.1, AW527142.1, AW491879.1, AW426950.1 , AW335961.1, AI229288.1, AI103583.1, AI155354.1, AI153477.1, AA895817.1 , AA739011.1 , AA290498.1, AA000364.1, AP001028.3, AC025920.8, AC024162.2, AC021006.3, AC020773.3, AC026197.1, AC026181.1, AC020755.2, AC024159.1, AC017539.1, AC006589.3, AC008141.2, AC068063.2, AC067757.1, AC046179.1, AC027654.1, AC019099.3, AC024944.2, AC016453.4, AC013350.6, AC024511.2, AC013816.3, AC023176.3, AC016525.3, AC02491 1.1, AC023157.4, ACOl 0734.3, AC008131.11 , ACOl 7700.1, AL356370.1, ALl 18519.20, AL137853.7, ALl 33388.3, AL354680.4, AL138848.3, AL353733.1, AL162430.1, AL157826.2, SEQ ID NO.195 NGO-Br-71 MK137/T3 5'

AB025608.1, AB009048.1, D45408.1, AB023029.1, AC005922.1, U64851.1, U92032.1, AJ001535.1, U66525.1, AB008265.1, AP000495.1, AC007187.4, AE003492.1, AC010125.3, AC002088.1, AC003071.1, AE001774.1 , AC005509.1, AC005900.1 , AEOOl 1 19.1, AC004063.1 , AF040653.1, AL353995.1 , AL031466.1, AL132715.2, AL161666.2, U28760.1, AL109609.5, AL031579.1, Z66567.1, Z82211.1, Z99129.1, AL021918.1, AL022159.1, AJ001088.1 , AL041831.1, AA911802.1, AI791494.1, AI791283.1, AW639607.1, AW540750.1 , AI553588.1, AI194910.1, AW565485.1, AW470837.1 , AW440357.1, AW106522.1, AV201819.1, AL037101.1, AV091786.1, AI444814.1, AI114364.1, AI002480.1, AA002743.1, AL355146.4, AL161434.3, AL132673.16, AL356292.1, AC027069.2, AC067734.3, AL161788.4, AC058786.7, AC025936.2, AC046186.2, AC009944.3, AC008459.4, AC026989.2, AC025669.2, AC026505.3, AC026390.1, AC024422.2, AC021696.3, ACOl 8826.3, AC012525.6, AL157785.2, AL355332.1, AC062004.2, AC013244.8, AC007943.2, AC027679.I, AC010429.4, AC027741.2, AC026557.2, AC012349.3, AC020732.3, AC027625.2, AC051630.1, AC026958.2, AC021514.3, AC012148.2, AC022580.2, AC009680.5, AC010993.10, AC010994.9, AC010730.4, AC010101.4, AC012195.2, AC014437.1, AC010843.8, AC018408.1, ACOl 1673.2, ACOl 11 14.1 , AC010132.2, AC007555.1, AC006799.1, AL356357.1 , AL356009.2, AL121954.4, AL139278.2, AL354920.1, AL139397.2, AL162719.1, AL138724.2, AP001954.1, AP001823.1,

SEQ ID NO.196 NGO-Br-71 MK137/T7 3'

AC006014.2, AC004705.2, AL035652.5, AC044786.2, AE002147.1, AC004848.1 , AC007735.2, AC004907.2, AF107885.2, U67494.1, AL161588.2, AL031986.1, AL022373.1, AI732538.1, AI652638.1, AA505930.1, AA991355.1, AW235448.1, AL041832.1, AI791494.1, AI791283.1, AL041831.1, AV254980.1 , AW552644.1 , AV267495.1, AV264008.1 , AV260689.1, AV259564.1, AV258534.1, AV208825.1, AV260910.1, AV264098.1, AW552124.1 , AW317034.1, AA391903.1 , AA536375.1, AA536264.1, AV210836.1, AW692176.1, AW438480.1, AJ388903.1,

AW210311.1, AI643503.1, AI545190.1 , AI394892.1, AI141264.1, AA497287.1, AA404284.1, AA256257.1, AW567217.1, AW361948.1, AV267670.1 , AU077746.1, AI906249.1, AI901829.1, AV034590.1, AI621492.1, AI551985.1, AI395360.1, AI179945.1, AU030825.1, AA906203.1, AA894271.1, AA852029.1, AA673655.1, C62664.1, C61515.1, AA445695.1, AA418204.1, AA141341.1, AAl 04978.1, H I 1780.1, R13493.1, T81922.1, Z44433.1, AL356292.1, AL355146.4, AL161434.3, AL132673.16, AL136305.5, AC007943.2, ACOl 1078.2, AL133508.2, AL138763.2, Z93245.1, ACOl 1585.3, AC018976.2, ACOl 1939.2, AC014847.1 , AC022442.3, AC009820.3, AC026491.3, AC022467.4, AC016221.4, AC021619.3, AL137017.5, AL121715.2, AL133322.3,

SEQ ID NO.197 NGO-Br-72 MK419/T3 5'

AK000528.1, NM_016123.1, AF1551 18.1, ALl 61587.2, M63234.1. AL031 135.1 , AC005868.1, AL096699.i l, X98048.1, NC_001148.1, AF249887.1, AC002392.2, AE003724.1, AF030694.2, NM_004690.1, AC007313.3, AF164041.1 , AC006559.6, AC007102.4, AF104413.1, AF104414.1, AE001409.1, AF015463.1, AC005220.1 , U67476.1, AL161573.2, ALl 61572.2, Z68136.2, AL049662.1 , ALl 21783.1 , S46763.1 , AL021749.1 , AL034558.2, U45981.1, Z70720.1 , Z73565.1 , Z29667.1, L34028.1, L34027.1, D10606.1, ABOl 1474.1, AB026649.1, M84660.1, M74445.1 , U07163.1, H53674.1, AI967314.1, AW560842.1, AW761247.1, AI794934.1, AI812788.1, AI774138.1, AI772185.1, AW876515.1, AW756795.1, AW329262.2, AW329038.2, AW649958.1, AW568064.1, AW496536.1, AW348715.1 , AW334566.1, AW094252.1 , AI960995.1, AI920205.1, C95693.1, AI594372.1, AA592233.1, H36649.1, T92029.1, T18143.1, AC016143.5, AC021719.3, AC025567.6, AC026763.5, AC010161.5, AL354696.1, AC022507.12, AC023928.3, AC009671.3, AC024954.2, AL354815.1, AL121880.15, AC024886.6, AC022072.8, AC031992.2, AC024244.4, AC067883.1 , AC057605.1, AC055596.1, AC055595.1, AC049865.1, AC049836.1 , AC048201.1, AC048200.1 , AC027086.2, AC021723.3, AC021849.3, AC013809.3, AC019131.3, ACOl 1308.3, AC013549.2, AC006091.9, AC017374.1, AL353592.1,

SEQ ID NO.198

NGO-Br-72

MK419/T7 3'

AK000528.1, NM H6123.1, AF155118.1, AC000118.1, AC004033.3, AC004232.1, AC009509.7, AL049839.3, AC008521.5, AL021546.1, AC003002.1, AC000378.1, AL096791.12, AC007227.3, AF051976.2, AC005859.1,

AC002565.1 , AL132639.2, AC005581.1 , AL035400.13, AP000180.1, AP000104.1, Z85987.13, AC005695.1, AC005563.1, AL049643.12, AC005821.1, AC005088.2, AC005031.1, AL135749.2, AL035249.6, AC004805.1, U52111.1, AL138976.3, AL121985.13, AC005914.1, AL035588.21, AC005081.2, AC005519.2, AC007993.15, AC005486.2, AL031848.11 , AC004223.1, AF001550.1, AL022318.2, Z98742.5, U62292.1, D84394.1, AP000313.1, AL163305.2, AL121988.10, AP001760.1, AF030876.1, AC005288.1, AC003663.1, AL121586.28, AC004858.2, AF001549.1, Z98200.8, AC002072.1, AC004887.2, AC002299.1, AC005874.3, AF134471.1, AC004477.1 , AC005730.1, AC006061.1 , AL021939.1, AJ010770.1, ACOl 1462.4, U47924.1 , AL035458.35, AL021937.1, AC008101.15, AC009247.1 1 , AC004771.1, AL031 133.1, AL049766.14, AC006115.1, AC002369.1, AL133500.2, AP000168.1, AP000053.1, AP000121.1 , AC000134.14, AC005803.1 , AC005514.1, AL031281.6, AC004745.1 , AL035422.12, AC0030O7.1, Z95152.1, AC004983.2, AL163282.2, AL163267.2, AP000045.1, AC005745.4, ACOl 1508.4, AL023879.1, AL022399.2, AAl 14131.1, H78605.1, H78687.1, AA084609.1, H07953.1, AA630854.1, AW02311 1.1 , AA501614.1 , T74524.1, AA468505.1 , AA614254.1, AI889579.1, AA515939.1, AA515728.1, AA612727.1, N64587.1, AW674631.1, AW069227.1, AI679002.1, AI634187.1, AI457313.1 , AA536040.1, AA485328.1, AI925869.1 , AA622801.1, AA602906.1, AA228368.1, W02749.1, R98218.1, AI653776.1, AI244157.1, AI708005.1, AI421257.1, AW082104.1 , AI962030.1, AA715173.1, AA715075.1, AA664126.1, AA297666.1, AL134940.1, AI733856.1 , AA613761.1, AA447247.1, AA347969.1, AA284247.1, C15363.1, T54783.1, AW151824.1, AI290405.1, AA864603.1, T49633.1, AW151201.1, AW090754.1, AI933714.1, AW304536.1, AI446336.1, AI278972.1, AA573213.1, AA456924.1, AA303054.1, R93919.1, AW341978.1, ALl 18612.1, AA552989.1, AW131356.1, AI754105.1, AA502991.1. T47936.1, AI733523.1, AI310343.1, AA669054.1, AA563770.1, AW844636.1, AW770827.1, AI669421.1, AA847499.1, AW576251.1, AW500684.1 , AW 192599.1,

AI755214.1, AI754567.1 , AI569100.1, AI249688.1, AI187148.1, AI080307.1, AI038304.1, AA584862.1 , AW 188742.1 , AI077941.1 , AA535216.1, T47324.1, AI817230.1, AI525100.1, AI560085.1 , AW510513.1, R66121.1, AI90481 1.1, AA779075.1, AL043144.2, AA225519.1, AC021719.3, AC016143.5, AL355386.1 , AC025262.5, AL356280.2, AL162411.1, AC008760.4, AC016953.5, AC010807.4, AL139252.2, AC026868.2, AC009470.3, AL353743.1, AC002993.1, AC009124.4, ACOl 8942.2, AC022826.3, AC023329.2, AL158196.4, AC025278.2, AC021258.3, AC025395.2, AL158165.3, AL034372.30, AL109806.13, AC037464.2, ACOl 1484.2, AC019194.2, AC016888.4, AL160010.3, AC016073.2, AC034198.2, AC027631.2, AL139807.5, AC007621.13, AC008812.6, AL162611.4, AC005995.2, AL121943.14, AC012014.5, AL355490.3, AC008731.4, AL354864.1 , AC019071.3, AC026469.3, AL354720.3, AL158014.4, AC026790.2, AP002016.1, AC008749.4, AC021852.3, AC012236.3, AL121845.18, AL163051.1, AC061979.2, AC012291.3, AC026160.1, AC024380.2, AC018808.3, AL158827.4, AC016554.5, AC022554.2, AC006393.6, AC005867.1, AL162584.2, AL161615.2, AL138788.1, AC010607.4, AC026286.2, AC026817.1, APOOl 177.1, AC025060.3, AC015714.4, ACOl 1247.3, AL121834.8, AL136450.1 , AC013564.3, AC012451.3, AC021510.2, AC016485.2, AL137186.4, AL162595.5, AL137247.3, AL137856.2, AC025695.3, AL158152.3, AC068485.1, AC008555.3, AC020697.3, AC010149.4, AL139255.1, ACOl 1501.5, AC008774.3, AC027551.2, AP001501.1, AC007366.3, AC041047.3, AL136139.5, APOOl 198.1 , AC022410.3,

SEQ ID NO.199 NGO-Br-73 MK642/T3 5' AF147338.1, AK000060.1 , AE003569.1, AFl 11426.1, AC007048.4, AC005385.3, U60334.1, AF020802.1 , ALl 63269.2, Z95889.1, Z83317.1, AP001724.1 , AP000687.1, AJ229041.1, AC008526.5, AC000122.1, AC005901.1, ALl 17327.5, AP000377.1, AE003526.1, AC007216.2, AC005249.1, U95742.1, AC006933.3, AC004512.1, AL133419.15, AI692537.1, AW243461.1, AW235223.1, AI671570.1, AW653857.1, AW274251.1, T58078.1, T58198.1, AW485453.1, AW428440.1, AA918819.1, AA01721 1.1, AA247593.1 , AV347965.1, AV103024.1, T27488.1, AV242595.1, AV341902.1, AV346780.1, Tl 1529.1 , AV245244.1, AV229602.1, AU03001 1.1, AW575669.1, AW557886.1, AW529718.1, AW212594.1, AV376787.1 , AV374992.1 , AV367312.1 , AV340052.1 , A V273236.1 , AV265359.1 , AV250828.1 , AV221007.1 , AV219070.1, AV218774.1, AV206725.1, AW066980.1 , AI847479.1 , AI837994.1, AI835991.1, AV159366.1, AV169546.1, AV152290.1, AV142949.1, AV141913.1, AV130057.1, AV126713.1, AVI 17344.1 , AVI 15850.1, AV102420.1, AV095928.1, AV075293.1, AV063673.1, AV057658.1, AV056084.1, AV056034.1 , AI747610.1, AV038768.1, AV030316.1, AV004917.1, AI574942.1, AI550786.1 , AI463222.1, AI462153.1, C78201.1, AA423250.1, AA259531.1, AC015955.4, AP001033.3, AC017914.1, AC012303.2, AL354863.4, AL139010.6, AC027201.2, AC012893.1, AL161612.4, AL022285.6, Z93065.1, AC017070.3, AC055820.2, AC026195.2, AC016205.4, ACOl 1178.3, AC012584.5, AC017432.1, AL160257.3, AC008784.5, AC010323.4, AC034299.2, AC034282.2, AC016893.3, AC032000.1, AC024010.2, AC023809.6, AC022375.1, AL138904.2, AL354990.1,

SEQ ID NO.200

NGO-Br-73

MK642/T7 3'

AF147338.1, AK000060.1 , X 80821.1, U60334.1, AE003480.1, AC000122.1, M96441.1, AC005901.1, AC000044.2, AC000034.2, AC004984.1, L28955.1, ALl 33367.2, AL080079.1, Z80901.1, AL033377.2, AI692537.1, AW653857.1 ,

AA918819.1 , T58078.1 , T58198.1 , AV349661.1, AV349644.1 , AV350717.1 , AV328677.1 , AW070252.1 , AW775904.1 , AW792828.1, AW274009.1, AW193700.1, AL121308.1, AW023476.1, AI910455.1 , AI765240.1, AI567672.1, AI376609.1, AI351633.1 , AI291783.1, AI291446.1, AA652658.1, AA570928.1, AA496039.1, H93102.1, R86033.1, R77622.1, R68550.1, AW774292.1, AW413948.1, AW155190.1, AW029172.1, AW009281.1 , AU069485.1, AU03001 1.1 , AI182684.1, AI122141.1, AI096187.1, AA839637.1, AA762941.1, AA691770.1 , C72277.1, AA548171.1 , AA451530.1, AA423704.1, W29889.1, H44377.1 , Tl 1529.1, AC015955.4, AP001033.3, AC021893.10, AC027514.2, AL139010.6, AP001460.2, AC026658.2, AC027061.2, AF235092.1, AC015631.3, AC023680.2, AC010000.2, AC015395.1, AL355377.2, AC024702.3, AC016493.3, AC024681.2, AC024087.3, ACOl 1940.3, AC022734.2, AC011916.1, AC010942.1, AC005000.1, AL161904.2, AL139300.2, SEQ ID NO. 201 NGO-Br-74 MK761/T3 5' AE003523.1, AC006257.1 , AC005330.1 , AL355927.1 , U56728.1, AL049766.14, AB037825.1, AK000573.1, AE003832.1, AE003801.1, AE003785.1, AC002087.1, NM_002172.1, AC004829.2, AC005887.3, U29244.1, AC004293.1 , X74470.1, Zl 1532.1, X72306.1, V00542.1, AA765066.1, R57163.1, AA896010.1, AA178333.1, C80989.1, AW105563.1 , AA930992.1, C80990.1 , C81381.1, AA612483.1, AA383435.1, AW326797.1, AW447131.1 , AA681894.1, AW104025.1, Z36392.1, Z36470.1, AW413469.1, AA684257.1 , AW149818.1, AI265028.1, AW781 170.1, AI907775.1, AA735139.1, AA371572.1, AA313662.1, AA299963.1, AA148581.1, AA135264.1, AW774261.1, AW609685.1, AW300461.1,

AI397692.1, AI069165.1, AI068528.1, AA841557.1, AA755125.1, AA623736.1, AC008795.5, AC008855.4, ACOl 1145.3, AC012122.2, AC055879.2, AC069189.1, AC017022.3, AC022187.2, AC013500.3, AC019563.1 , AL162579.4, AC026334.3, AC069079.1, AC069026.1, AC027328.2, AC010337.3, AC010472.4, AC008549.4, ACOl 1448.2, AC026393.2, ACOl 1289.3, AC027094.2, AC025974.2, AC025956.2, AC022823.3, AC017010.2, AC015904.3, AC013370.5, AC007477.5, AC020693.3, AC022302.3, AC007413.4, AC007330.5, AC017049.3, AC022176.1, AC019249.3, AF209070.1, AC018198.1, AC017513.1 , AC015178.1 , AL353664.3, AL354675.2, AL353690.1, AP001372.1, AP001367.1, APOOl 103.2, AP001085.2, AP001030.2,

SEQ ID NO.202 NGO-Br-74 MK761/T7 3'

AC025098.4, AC005560.2, AC027661.1, ACOl 1806.1 , AC006257.1, AC005330.1, AL355927.1, U56728.1, AL049766.14, AB037825.1, AK000573.1, AE003801.1, AE003478.1, NM_006496.1, NM_002172.1, AC005887.3, AC009465.5, U29244.1, AC005317.1, AC004293.1, AL023518.2, X74470.1, Zl 1532.1 , V00542.1, X54048.1, AK001973.1, AK001746.1, M27543.1, AB014467.1, J03198.1, AA765066.1 , R57163.1, AW105563.1, C80989.1, C80990.1, C81381.1, AA896010.1, AA178333.1, AA930992.1, AA612483.1, AA383435.1, AW104025.1, AA681894.1, AW326797.1, AW447131.1, Z36392.1, Z36470.1, AW413469.1, AA684257.1, AI265028.1, AW149818.1, AI453042.1, AW781170.1, AV349095.1, AV248065.1, AI907775.1, AA735139.1, AA371572.1 , AA313662.1, AA299963.1, AA148581.1, AA135264.1, AV211122.1, AI829193.1, AV172729.1 , AI766084.1, AI620180.1, AI400167.1 , AI397692.1, AI356812.1, AI337030.1 , AI269102.1 , AI261301.1, AI092059.1 , AI033551.1 , AI033398.1 , AA954839.1 , AA838238.1 , AA766120.1 , AA755125.1, AA736929.1, AA706621.1 , AA704130.1, AA652992.1, C72329.1, AA587349.1, AA490356.1, AA235987.1 , AA085406.1, AC008795.5, AC008855.4, ACOl 1 145.3, AC012122.2, AC022061.2, AC016691.4, AC022960.2, AC009831.3, AC055879.2, AC027133.1, AC017022.3, AC019563.1, AL162579.4, AC027328.2, AC015904.3, AC024016.2, AL355310.3, AL353664.3, AL354675.2, AL139802.3,

SEQ ID NO.203

NGO-Br-75

MK344/T3 5'

AL157792.2, AL033380.11, U55042.1, X64070.1, AC006607.1, AC006576.15, AF070718.1, AC004703.1, AL122003.17, AB015752.1, ACOl 1309.4, AF030876.1, NM_013369.1 , U82695.2, AF031075.1, AF194032.1, AF081058.1, AF081057.1 , AF081056.1 , AF081055.1 , AF058419.1, U68299.1 , U52112.1 , ALl 63298.2, AL080286.16, AL096677.18, L06231.1, X53705.1, AP001753.1, AP001059.1, X81326.1, X53709.1, X53708.1 , D86115.1, AW650954.1, ALl 19238.1, AW030498.1, AI661495.1 , AA831895.1, AW393793.1, AW393785.1, AW213405.1, AV230556.1, AW124066.1, AI931357.1, AV124496.1, AI631758.1, AI585396.1, AA918201.1 , AA890172.1, AA882048.1, AA757981.1, AA538210.1, AA474203.1, AA402070.1, AA199109.1, AA053059.1, R82169.1, R23708.1, AC063960.2, AC012053.2, AC020661.4, AC023137.2, AC026045.3, AC034236.1, AC016530.3, AC019068.3, AC015557.1, AL138781.3, AL162151.2, AC062006.2, AC044906.2, AC036174.2, AC021 165.3, AC023133.2, AC009677.3, AC021462.3, AL353803.1, ALl 60268.3, SEQ ID NO.204 NGO-Br-75 MK344/T7 3'

AL049749.2, Z83733.1, AE003545.1, U97009.1, AC005512.1, Z78018.1, AB036794.1, AC008701.5, AC006319.3, AC004160.1, AC005026.1, AL049859.7, Z69637.1, AL035686.12, AE003804.1, AE003275.1, NC_002387.1, U17009.2, AC002066.1, AJ133269.1, AL030995.1, AI964952.1, AW847510.1, AW453459.1, AW125886.1, AI562053.1, AI180354.1, AI130241.1 , AW840570.1, AW840396.1, AW795642.1, AW600573.1, AW588022.1, AW455711.1, AW331252.1, AW306566.1, AI913878.1, AI813344.1, AI767557.1, AI593529.1 , AA888474.1 , AA603364.1, AA601251.1, AA550370.1, AA428312.1, AA305564.1, D78836.1 , Z45190.1, AC063960.2, AC006447.17, ACOl 1085.4, AC023285.2, AP001027.1, AL355358.1 , AC025684.2, AC021877.4, ACOl 1243.3, AL160291.2, AC006404.20, AC015424.1, AC019870.1, AC020079.1, AC007835.5, AC010565.3, AC010690.1 , AC068007.1 , AC062025.1, AC009578.3, AC023820.2, AC015567.3, AL109965.22, AL132671.19, AC069237.1, AC044882.2, AC068593.1, AC064847.1, AC023136.3, AC021555.3, AC026242.3, AC013685.3, AC016808.2, AC017040.3, AC013278.1, AP002000.1 , APOO 1931.1,

SEQ ID NO.205 NGO-Br-76 MK415/T3 5'

AB033888.1, NM_009236.1, L35032.1, AF047389.1, AF047043.1 , AF017182.1, U66141.1, AJ001029.1, NM_000346.1, AFl 16571.1, NM_006941.1, NM_005686.1, AF149301.1 , AC007461.8, AF006501.4, AF098915.1, AF083105.1 , AF029696.1 , AL031587.3, S74504.1, Z46629.1, AJ001183.1 , L29086.1, U08223.2, NM_007084.1, NM_009238.1, NM_009233.1, NM_009234.1, NM_005986.1, AF107044.1, AF061784.1, AF009414.1, AL163672.1, AX001335.1, AX001334.1, U12533.1, AJ004858.1, X96997.1 , X70298.1, X94126.1, AB014474.1 , D61688.1, M90534.1, D83649.1, AB012236.1, Y13436.1, AA764352.1, AW321606.1, AL043036.2, AL120408.1, AA172336.1, AW533152.1, AW532037.1, AW532030.1 , AW529354.1, AW414006.1, AW251615.1, AW060475.1, AI884987.1, AI816765.1, AVI 16901.1, AI6001 15.1, AI594348.1, AI569726.1, AA965274.1, AI416080.1 , AI406268.1, AI327463.1, AI176078.1, AI137787.1, AA734962.1, AA616534.1, AA521730.1, AA040785.1, AW822773.1, AW506135.1, AW417535.1, AW046996.1, AW015864.1, AI566947.1, AI552551.1, AI359981.1, AL355803.2, AC024914.17, AL137061.2,

SEQ ID NO. 206 NGO-St-114 5' combined;

AC005618.1, X97999.1 , NM_005642.1, U18062.1 , Z65840.1, NM_011901.1 , AF144562.1, Z65839.1, AC004540.1, AL137039.1, U20660.1, AE003630.1, U15947.1, AL132889.2, AL132885.1, AE003646.1, AE003605.1, AE003412.1, AF146393.1, AC004058.1, U32788.1, AC004056.1, AL355094.2, AJ131018.1, Z97180.1, AP001821.1 , AC005825.3, AC006804.3, AE003778.1, AE003576.1, AE003510.1, AF136829.1, AF081203.1 , AC004992.1, AF195611.1 , AF195610.1, AC006961.16, AC006581.16, AC005414.2, U68299.1, AF016687.1, U23527.1, L78833.1 , U18349.1, AC004267.1,

AF047659.1, U09744.1, ALl 17206.1, AL137080.2, Z81467.1, Z81028.1, Z82180.19, Z77652.2, Z75892.1, AL050305.9, Z77249.1 , Z97629.1 , AJ250862.1 , U55366.1 , X06535.1 , U40028.1 , APOOl 331.1, APOOl 111.1, AB029433.1 , AB003324.1 , D00170.1, Y17816.1, AU077198.1, AW673639.1, AA315968.1, AW029214.1, AA622246.1, D59188.1, AI904582.1, AW877796.1, AA595371.1, AA278660.1, AW877790.1, AA894917.1, AA252724.1 , AA328618.1, AW402842.1 , AW362899.1, H14854.1, AW394189.1, AA312894.1, AW365030.1 , T72766.1, AW582369.1 , T65190.1, T52076.1,

AW609538.1, AW366774.1, AA372836.1, AW380678.1, AA460590.1, Fl 1914.1, AA383821.1, T47333.1, AA336307.1, AW403760.1 , AA337398.1 , AI951709.1 , T34968.1 , AA346865.1 , ALl 19477.1 , AW816164.1 , AA348197.1 , AA619797.1 , T05543.1, AI158644.1, T83104.1, C03576.1, C03455.1, T86869.1, AV121343.1, AA572579.1, AA095559.1, AA517694.1, AA920998.1, AV205440.1, AA763469.1, AV212370.1, All 17791.1, AV213552.1, AV212700.1, C89279.1, H21207.1, AV216550.1, AV100198.1, AV218081.1 , AV214781.1, AW199703.1 , AI722257.1, AA336858.1 , AA102949.1,

AA182987.1, W26005.1, AW645787.1, AW638295.1, AW199696.1, R52386.1, AW563125.1, AW563124.1, AW506736.1, AW506735.1, AW506714.1, AW506713.1 , AW433456.1, AW330840.1 , AW056105.1, AI987345.1 , AW728753.1, AI519245.1 , AI511851.1 , AI456317.1 , AI455940.1 , AA264246.1 , AI756661.1, AI755675.1 , AC008579.2, AC020971.1, AC025193.1, AC021705.4, AC025256.4, AC068708.2, AC020898.3, AC020907.3, AC009035.5, AC026886.2, AC021271.4, AC025944.3, AC025945.2, AC026220.2, AC007186.8, AC019704.1, AC015613.1, AC007913.1,

AL158151.5, AL157888.2, AL136135.2, AL133263.2, Z98857.36, AC026124.3, AC027751.2, AC026384.2, AC024050.6, AC019207.3, AC020725.3, AC019835.1 , AC014673.1, AC008189.2, AL109836.17, AP001894.1, AP001863.1, AP001548.1, AP001544.1, AP001493.1, AP001282.1, AP000906.2, SEQ ID NO.207 NGO-St-114 YS071/T3 5'

NM_005642.1, AC005618.1, U18062.1, X97999.1, NM_01 1901.1, AF144562.1, Z65840.1, AE003630.1, U15947.1 , AL132889.2, AL132885.1, AF146393.1 , AC004058.1, AJ131018.1 , AP001821.1, AE003778.I , AE003576.1, AC004992.1 , AC005414.2, AF016687.1 , L78833.1, AC004267.1, AF047659.1, Z81028.1 , U55366.1, U40028.1, AW029214.1, AU077198.1, AW877796.1, AW877790.1, AA595371.1, AA252724.1, AA894917.1, AA622246.1, AA312894.1, AA328618.1 , AA460590.1, AW403760.1 , T47333.1, AI904582.1, T72766.1 , AA278660.1 , AA372836.1 , Fl 1914.1, T34968.1, T65190.1, AW673639.1, H14854.1, T05543.1, AA383821.1, AI158644.1 , AA315968.1, AA572579.1 , AW402842.1 , AA517694.1, AW362899.1, AW582369.1, AV121343.1, AA920998.1, AW816164.1, AW394189.1, AV205440.1, C89279.1 , AV213552.1, AV212370.1, AW609538.1, AV212700.1, AW365030.1, AA619797.1,

AW380678.1, C03576.1, AV216550.1, AV100198.1, AI722257.1, AA182987.1 , AV218081.1, AV214781.1, ALl 19477.1, D59188.1 , AW645787.1, AW638295.1 , AW199703.1, AW199696.1 , AW728753.1, AI519245.1, AI51 1851.1, AI456317.1, AI455940.1 , AA264246.1, AI471 179.1, AW375040.1, AW375037.1 , AW021363.1, AI976597.1 , AV049065.1, C54464.1, C54153.1, C51985.1 , AA426143.1, AA406093.1, Cl 1684.1, R74232.1, D27736.1, AC008579.2, AC020971.1 , AC025193.1, AC020907.3, AC007186.8, AC019704.1, AL136135.2, AL133263.2, Z98857.36, AC026124.3, AP001863.1, AC068193.4, AC036188.2, AC024947.2, AC025766.3, AC010623.3, AC016558.3, AC008534.3, AC036127.2, AC068579.1, AC009142.4, ACOl 1724.2, AC024698.4, AC022198.2, AC021719.3, AC022788.2, AC010764.3, AC009695.4, AC025532.2, AC021157.3, AC016890.4, AC022273.2, AC016685.4, ACOl 1266.3, AC023349.2, AC018492.3, AC012101.3, AC024158.1, AC012448.3, AC010741.3, AC012387.4, AC017805.1, AC014787.1, AC006937.5, AC006905.1, AL356435.1, AL109955.13, AL135939.9, AL133542.3, AL161790.3, AL162418.2, AL159176.3, AP001993.1,

SEQ ID NO. 208 NGO-St-114 YS071 T73'

NM_005642.1, AC005618.1, U18062.1, X97999.1, NM_011901.1, AF144562.1, AL009178.4, AB016897.1, AL109801.13, AE003618.1, AC007504.3, AC007172.6, AC005834.1, AB007651.1, AE003764.1 , AE003738.1, AL078581.1 1, AL031259.1 , Z81455.2, Z82900.1 , AB025604.1 , Z30211.1 , ACOl 2082.6, AC004747.2, AC004521.2, AC024750.1, AF233591.1, AC012099.4, AC003012.1 , AC005076.2, AC007269.2, AF121898.1, AC006075.1, AC004583.1, AF042091.1. AL163282.2, ALl 17191.4, AL121716.16, AL161585.2, AL121754.18, AL008723.8, AL021182.1 , AL031429.1 1 , AL035593.11 , AL023094.2, U37796.1 , X04112.1 , X 15215.1 , AI052691.1 , AI346408.1 , AW304965.1 , AI709369.1, AW190867.1, AW192823.1, AI818211.1, AI434577.1 , AW264130.1, AA613880.1, AA507377.1, AA417113.1, AI675129.1, AI371764.1, AI28561 1.1, AI125952.1, AW069225.1, AI376092.1, W65333.1, AI804531.1, AI366201.1, AI940448.1, AW860175.1, AW604918.1, AA461518.1, AA063580.1, AA825152.1, AA604623.1,

AI278875.1, AA947107.1, AA417019.1 , W39724.1, AI274749.1, W15503.1, AA776228.1, AW512466.1, W61316.1, AI090392.1 , AI356847.1 , AW607519.1 , AA975911.1, AA037065.1 , AA838760.1 , AW089083.1 , AA635906.1 , AA824551.1, AA602587.1, AW265444.1, AA188912.1, T90567.1, AW519252.1, AW150510.1, R73733.1 , AA508614.1, W56065.1, T86870.1, ALl 18821.1, AA508722.1, AA886319.1, AA577447.1, AA380499.1 , AA314905.1, AA854628.1, AA412648.1, H84875.1, AW614384.1, F09561.1 , AA326994.1, AA037079.1 , AA380870.1, R30839.1, AI287373.1,

AI654286.1, R27607.1, T65121.1, H85281.1, N87733.1 , AA715623.1, AA946962.1, AA460590.1, AA628285.1, C02002.1, AA894943.1, AA876963.1, AI431981.1, AA58521 1.1, AI216614.1 , AA381394.1, AA278612.1, AA585402.1, AW463162.1, D80075.1, R52386.1, AA036649.1 , A A671025.1, AA369696.1, AW057744.1, T86869.1 , AA794137.1, AW414681.1, AC020971.1, AC025419.6, AC021297.2, AC020004.1, AC064829.3, AC009954.3, AC011791.3, AC013328.5, AC007819.7, AC009807.3, AC016991.2, AC009345.6, AC008043.3, AC018408.1, AC017738.1,

AC018228.1, AL138817.5, AL356212.1, AL133518.3, AL136980.3, AL139294.1, AL03101 1.20, AP000708.1, Z82169.1, Z95393.1,

SEQ ID NO.209 NGO-St-114 YS081/T3 5'

AC005618.1, X97999.1 , NM_005642.1 , Ul 8062.1 , Z65840.1 , Z65839.1 , AC004540.1 , ALl 37039.1 , AE003630.1 , AL132889.2, AL132885.1, AE003646.1, AE003605.1, AE003412.1, AC004058.1, AC004056.1, Z97180.1 , AP001821.1, AC006804.3, AE003778.1, AE003576.1, AE003510.1, AF136829.1, AC006961.16, AC006581.16, AE001546.1, U68299.1 , U18349.1, AC004267.1, AF047659.1, U09744.1, Z77249.1, U55366.1 , X06535.1, APOOl 11 1.1 , AB029433.1, Z95704.1 , AB003324.1 , D00170.1 , Yl 7816.1 , AU077198.1 , AW673639.1 , AA315968.1 , D59188.1 , T52076.1 , AA312894.1 , AW366774.1 , AA336307.1 , AA337398.1 , AI951709.1 , AA460590.1 , AL 119477.1 , AA348197.1 , T86869.1 , AA095559.1, AW029214.1, AW877796.1 , AW877790.1, AA595371.1, AA252724.1, AA894917.1, AW563125.1, AW563124.1, AW506736.1, AW506735.1, AW506714.1, AW506713.1, AW433456.1, AW330840.1, AW056105.1, AI987345.1, AI519245.1, AI511851.1, AI456317.1, AI455940.1, AA264246.1, AW649858.1, AW622907.1, AW217541.1, AW217534.1, AI239260.1, C93674.1, AW787238.1, AW787237.1, AW597401.1, AW565183.1 , AW352495.1, AW331243.1, AW286148.1, AI668513.2, AW021363.1 , AI976597.1, AI966918.1 , AI966929.1, AI964567.1 , AV155610.1, AI756661.1, AI755675.1, AV049065.1, AI746131.1, AI711682.1, AI677124.1, AI667849.1 , AI665080.1, AI637127.1 , AI549172.1, AI461446.1, AI461444.1, AA979929.1 , AA979727.1 , C72737.1, AA426143.1, AA406093.1 , AAl 23407.1, C19565.1, R74232.1, T18355.1, AC008579.2, AC021705.4, AC007186.8, AC019704.1, AC007913.1, AL158151.5,

Z98857.36, AC025179.3, AC008814.3, AC026384.2, AC024050.6, AC019207.3, AC020725.3, AC019835.1, AC014673.1, AC008189.2, AL109836.17, AL161444.2, AP001894.1, AP001863.1, AP001548.1, AP001544.1, AP001493.1, AP001282.1, AP000906.2, AC068193.4, AC012386.9, AC006513.25, AC068979.2, AC036188.2, AC008533.5, ACOl 1367.5, AC011371.4, AC009142.4, AC025796.2, AC021409.3, AC010764.3, AC021373.3, ACOl 1693.4, AC016685.4, AC018862.3, AC018994.3, AC012109.2, AC010741.3, AC012726.1, AC017805.1, AC014787.1, AC006937.5, AC006871.1, AC006803.2, AL354880.3, AL109955.13, AL139119.5, AL135939.9, AL355804.2, AL354674.2, AL161790.3, AL159176.3, AL157770.2, AP001993.1, AP001806.1 , AP001457.1, AP000881.I , APO00826.1, AP000646.1. AP000621.1, SEQ ID NO.210 NGO-ST-114 YS081 T7 3'

NM_005642.1, AC005618.1, U18062.1, X97999.1, NM_01 1901.1, AF144562.1, AE003618.1, AC004927.2, AC007172.6, AC005834.1 , AE003738.1, AF165124.1 , AL163258.2, AL078581.1 1, AL031259.1 , AL109801.13, Z81455.2, L77246.1, AP001713.1, AP000178.1, AP000033.1, AP000266.1, AP000102.1, Z991 15.1, M15318.1, AC004747.2, AE002267.1,

AC004828.2, AE001658.1, AC004583.1, AF042091.1, AL355101.2, AL163282.2, AL109985.2, AL049569.13, U37796.1, X76272.1, X04112.1, X15215.1, AB018107.1, AI434577.1, AI371764.1, AA947107.1, AW519252.1 , AA776228.1 , AW512466.1, AW304965.1, AW264130.1, AI376092.1, AI274749.1, AI090392.1 , AI052691.1, AA824551.1, AA635906.1, AA604623.1, AA507377.1 , AA417019.1, AA188912.1 , AA063580.1, W61316.1, AI346408.1, AA825152.1, AW069225.1, AA037065.1, AI675129.1, AI285611.1, AI278875.1, AI125952.1, AA975911.1, AA613880.1, AA602587.1, AA461518.1, W15503.1, AW089083.1, AW190867.1, T90567.1, W56065.1, AW265444.1, AI356847.1, T86870.1, AA838760.1, AI818211.1, AI366201.1, AA417113.1 , AW192823.1, AI709369.1, AW150510.1, AA508614.1 , AA886319.1, AA577447.1, AW607519.1 , AA380499.1, AA854628.1, H84875.1, AA508722.1, AW614384.1, F09561.1 , AI940448.1, AW860175.1, AW604918.1 , W65333.1, W39724.1, AA314905.1, AA326994.1 , AI804531.1 , R73733.1, AA412648.1, AI287373.1, ALl 18821.1, R27607.1, AA037079.1, T65121.1, AI654286.1, AA380870.1, N87733.1, AA715623.1, AA946962.1, C02002.1, AA628285.1, H85281.1, AA460590.1, AA894943.1, AA876963.1, AA585211.1, AI216614.1, R30839.1, AA278612.1, AA585402.1, D80075.1, AA036649.1, AW057744.1, AA794137.1, AA671025.1, AI431981.1, AA381394.1, AA794920.1, AW463162.1, AI607308.1, AA691044.1, AW414681.1, AC020971.1, AC025419.6, AC020004.1, AC064829.3, AC064826.2, AC034126.2, AC016547.5, AC008835.3, AC026466.3, AC009954.3, AC024883.3, ACOl 1791.3, AC016991.2, AC008043.3, AC018408.1, AC017738.1, AL133518.3, AL133472.3, AL031011.20, Z95393.1, AC007834.20, AC007623.20, AC009757.7, AC021171.3, AC010644.5, AC010590.4, AC008825.3, AC027749.2, AC024483.2, AC015533.4, AC027630.4, AC024466.3, AC018737.2, AC024399.2, AC009554.4, AC026890.1, AC026021.1, AC016063.4, ACOl 1781.4, AC016357.6, AC022518.2, AC013478.3, AC015826.2, AL356212.1, AL137140.5, AL136359.4, AL161900.3, AL122125.1, AL139294.1, AP001872.1,

SEQ ID N0.211 NGO-St-114 YS1615/T3 5' X97999.1, AC005618.1, NM_005642.1, U18062.1, NM_011901.1, AF144562.1, U20660.1, U15947.1, AL132889.2,

AL132885.1, AF146393.1, AC004058.1, AJ131018.1, AP001821.1, AE003778.1, AE003576.1, AC004992.1, AF195611.1, AF195610.1, AC005414.2, AF016687.1, L78833.1, AC004267.1, AF047659.I, ALl 17206.1, Z81467.1, Z81028.1, Z82180.19, Z77652.2, Z75892.1, AL050305.9, Z97629.1, U55366.1, U40028.1, AW029214.1, AA622246.1, AI904582.1, AW877796.1, AA595371.1, AW877790.1 , AA278660.1 , AA894917.1, AA252724.1, AA328618.1, AW402842.1, AW362899.1, H14854.1, T72766.1, AW394189.1, T65190.1, AW365030.1, AA372836.1, AW582369.1, Fl 1914.1,

AU077198.1, AW609538.1, AW380678.1, AA383821.1, T47333.1, AW403760.1, T34968.1, AA460590.1, AA312894.1, AW816164.1, AA346865.1, AA619797.1, T05543.1, AI158644.1, AV121343.1, AA572579.1, C03576.1, AA517694.1, T83104.1, C03455.1, AA920998.1, AV205440.1, AV212370.1, AV213552.1, AV212700.1, C89279.1, AA763469.1, H21207.1. AV216550.1, AH 17791.1, AV100198.1, AV218081.1, AV214781.1, AW199703.1, AI722257.1, AA182987.1, AA336858.1, AW645787.1, AW638295.1, AWl 99696.1, AW728753.1, AA102949.1, AI471179.1, AW375040.1,

AW375037.1, AV049065.1, C54464.1, C54153.1, C51985.1, C49917.1, Cl 1684.1, D27736.1, AC008579.2, AC02097I.1, AC025193.1, AC025256.4, AC020898.3, AC020907.3, AC009035.5, AC015613.1, AL136135.2, AL133263.2, Z98857.36, AC026124.3, AC027751.2, AP001863.1, AC068193.4, AC036188.2, AC024947.2, AC025972.2, AC041033.2, AC026404.4, AC025766.3, AC024583.3, AC010243.3, AC010273.3, AC010302.3, AC010623.3, AC016558.3, AC008534.3, AC036127.2, AC068579.1, AC009171.4, AC009142.4, AC013670.3, AC017106.3, AC018686.4, ACOl 1724.2, AC024698.4, AC022198.2, AC021719.3, AC019033.4, AC022788.2, AC023629.2, AC010764.3, AC021828.2, AC009695.4, AC025532.2, AC021157.3, AC016890.4, AC022273.2, AC016685.4, ACOl 1266.3, AC023349.2, AC018492.3, AC012101.3, AC024158.1, AC012448.3, AC010741.3, AC012387.4, AC017805.1, AC014787.1, AC006937.5, AC006905.1, AC006704.1, AL356435.1, AL355593.3, AL133542.3, AL161790.3, AL162418.2, AL159176.3, Z92842.1, Z92863.2, AP001993.1,

SEQ ID NO.212 NGO-ST-114 YS1615/T7 3' AC005618.1, NM_005642.1, U18062.1, X97999.1, NM_011901.1, AF144562.1, AL009178.4, ABO 16897.1, AE003618.1, AC007504.3, AB007651.1, AE003764.1, AE003738.1, AF165124.1, AL078581.11, AL031259.1, Z81455.2, Z82900.1, L77246.1 , AB025604.1 , Z99115.1 , M 15318.1 , Z30211.1, ACOl 2082.6, AC004521.2, AC024750.1 , AE003600.1 , AF233591.1, AE001658.1, AF121898.1, AF022814.1, AF042091.1, AF005383.1, ALl 17191.4, AL121716.16, AC002077.1, AL021 182.1, AL031429.11, X76272.1, X04112.1, X15215.1, AI052691.1, AI346408.1, AW304965.1, AW190867.1, AI709369.1, AW192823.1, AI818211.1, AI434577.1, AW264130.1, AA507377.1, AA613880.1,

AA417113.1, AI675129.1, AI371764.1, AI285611.1, Al 125952.1, AI376092.1, AW069225.1, AI366201.1, AI804531.1, AA063580.1, AA461518.1, W65333.1, AA825152.1, AA604623.1, AA947107.1, AI278875.1, AA417019.1, AI274749.1, W15503.1, AA776228.1, AW512466.1, W61316.1, AI090392.1, AI940448.1, W39724.1, AI356847.1, AW860175.1, AW604918.1, AA975911.1, AA037065.1, AA838760.1, AA635906.1, AW089083.1, AA824551.1, AA602587.1, AW265444.1, AA188912.1, AW519252.1 , T90567.1 , AW150510.1, AA508614.1, W56065.1, AW607519.1, T86870.1, R73733.1, AL118821.1, AA886319.1, AA508722.1, AA577447.1, AA380499.1, AA854628.1, H84875.1, AW614384.1, F09561.1, AI287373.1, AA314905.1, AA326994.1, R30839.1, R27607.1 T65121.1, AA412648.1, AI654286.1, N87733.1, AA715623.1, AA037079.1, AA946962.1, AA380870.1, C02002.1, AA628285.1, AA894943.1, AA876963.1, AI431981.1, AA460590.1, H85281.1, AA585211.1, AI216614.1, AA278612.1, AA585402.1, D80075.1, AW057744.1, AA381394.1, AA036649.1, AA794137.1, AA691044.1, AA671025.1, AA794920.1, AW414681.1, AW463162.1, AA549454.1, AC020971.1, AC025419.6, AC064829.3, AC064826.2, AC008835.3, AC013328.5, AC009807.3, AC018408.1, AC017738.1, AC018228.1, AL138817.5, AL133472.3, AL136980.3, Z82169.1, AC009757.7, AC060773.2, AC036223.2, AC008825.3, AC027438.2, AC015679.3, AC015964.2, AC021450.3, ACOl 1218.4, AC022625.1, AC006719.1, AL163153.1,

SEQ ID N0.213

NGO-St-114

YS1631/T7 3'

NM_005642.1, AC005618.1, U18062.1, X97999.1, NM_011901.1, AFl 44562.1, AL009178.4, AB016897.1, AE003618.1, AC007504.3, AB007651.1 , AE003738.1, AF165124.1 , AL078581.11, AL031259.1, AL109801.13, Z81455.2, Z82900.1, L77246.1, AB025604.1, Z99115.1, M15318.1, Z30211.1, AC012082.6, AC004521.2, AC024750.1, AC012099.4, AL121716.16, AL021182.1, AP001037.1, AI052691.1, AW304965.1 , AI709369.1, AI346408.1 , AWl 90867.1, AW192823.1. AI81821 1.1, AI434577.1 , AW264130.1, AA507377.1, AA613880.1 , AA4171 13.1, AI675129.1. AI371764.1, AI285611.1, AI125952.1, AI376092.1, AW069225.1, AI366201.1, AI804531.1, AA461518.1, AA063580.1, W65333.1, AA825152.1, AA604623.1, AA947107.1, AI278875.1 , AA417019.1, AI274749.1, W15503.1, AA776228.1 , A W512466.1, W61316.1, AI090392.1, AI356847.1, W39724.1, AA975911.1 , AA037065.1, AI940448.1, AW860175.1 , AW604918.1, AA838760.1, AW089083.1, AA635906.1, AA824551.1, AA602587.1, AW265444.1, AA188912.1, AW519252.1 , T90567.1 , AWl 50510.1 , AA508614.1 , W56065.1 , T86870.1 , ALl 18821.1 , R73733.1 , AA508722.1 , AA886319.1 , AW607519.1, AA577447.1, AA380499.1, AA854628.1, H84875.1, AW614384.1 , F09561.1, AI287373.1, R30839.1 , AA326994.1, R27607.1, T65121.1 , AA314905.1, AI654286.1 , N87733.1, AA412648.1 , AA715623.1, AA946962.1 , AA628285.1, C02002.1, AA037079.1, AA380870.1 , AA894943.1, AA876963.1, AI431981.1, AA58521 1.1, AI216614.1, AA460590.1, H85281.1, AA278612.1, AA585402.1, D80075.1, AW057744.1 , AA794137.1, AA691044.1 , AA671025.1, AA794920.1, AW414681.1, AA381394.1, AA036649.1, AI859319.1, AW463162.1, AC020971.1, AC025419.6, AC064829.3, AC064826.2, AC034126.2, AC008835.3, AC013328.5, AC009807.3, AC018228.1, AL133472.3, ALl 36980.3, AC023599.7, AC068540.2, AC009757.7, AC060773.2, AC036223.2, AC008825.3, AC026083.3, AC027438.2, AC015679.3, AC015964.2, ACOl 1218.4, AC024065.2, ACOl 1647.3, AC013478.3, AC006719.1, ALl 35842.4, SEQ ID NO. 214 NGO-St-1 14 YS1682/T3 5'

AC005618.1, X97999.1 , NM_005642.1 , U 18062.1 , Z65840.1 , Z65839.1 , AC004540.1 , ALl 37039.1 , AE003630.1 , AE003646.1, AE003605.1, AE003412.1 , AC004058.1, AC0O4056.1, AL132889.2, Z97180.1, AL132885.1, AP001821.1, AC004005.2, AC006804.3, AE003778.1, AE003510.1, AF136829.1, AC006961.16, AC006581.16, U68299.1, U18349.1, AF047659.1, U09744.1, Z77249.1 , U55366.1, X06535.1, APOOl 111.1, AB029433.1, AB003324.1, D00170.1, Y17816.1, AU077198.1, AW673639.1, AA315968.1, D59188.1, T52076.1, AW366774.1, AA336307.1, AA337398.1, AA312894.1, AI951709.1, ALl 19477.1, AA348197.1, AA460590.1, T86869.1, AA095559.1 , AW029214.1, AA252724.1, AW877796.1, AW877790.1, AW563125.1, AW563124.1 , AW506736.1, AW506735.1, AW506714.1, AW506713.1, AW433456.1, AW330840.1, AW056105.1 , AI987345.1, AI519245.1 , AI51 1851.1, AI456317.1 , AI455940.1 , AA264246.1, AW649858.1 , AI239260.1 , C93674.1, AW787238.1, AW787237.1, AW597401.1, AW565183.1, AW352495.1, AW331243.1, AW286148.1, AI668513.2, AW021363.1, AI976597.1 , AI966918.1, AI966929.1, AI964567.1, AI857189.1, AI756661.1, AI755675.1 , AV049065.1 , AI746131.1 , AI71 1682.1 , AI677124.1 , AI667849.1 , AI665080.1 , AI637127.1 , AI549172.1 , AI461446.1, AI461444.1, AA979929.1, AA979727.1 , C72737.1, AA426143.1, AA406093.1, C19565.1, R74232.1', T18355.1, AC008579.2, AC021705.4, AC007186.8, AC019704.1, AC007913.1, AL158151.5, AC068193.4, AC026384.2, AC024050.6, AC019207.3, AC020725.3, AC019835.1, ACO 14673.1 , AC008189.2, AL109836.17, AL159176.3, Z98857.36, AP001894.1, AP001863.1, AP001548.1, AP001544.1, AP001493.1 , AP001282.1, AP000906.2, AC012386.9, AC006513.25, AC068979.2, AC036188.2, AC009142.4, AC025796.2, AC021409.3, AC021373.3, AC016685.4, AC012109.2, AC012726.1 , AC014787.1, AC006871.1 , AC006803.2, AL354880.3, AL109955.13, AL135939.9, AL355472.2, AL355804.2, AL354674.2, AL157770.2, AP001993.1, AP001806.1, AP000881.1, AP000826.1, AP000646.1, AP000621.1,

SEQ ID NO. 215 NGO-St-114 YS1743/T3 5'

AC005618.1, X97999.1 , NM_005642.1 , U 18062.1 , Z65840.1 , Z65839.1 , AC004540.1 , ALl 37039.1 , AE003630.1 , AC000003.1, AE003646.1, AE003605.1, AE003412.1, AC004254.1, AC004056.1, AL035448.28, Z97180.1 , AC006804.3, AE003758.1 , AE003634.1 , AE003597.1 , AE003510.1 , AC007029.3, AF 136829.1 , AC000064.1 , AC002458.1 , NM_004703.1, AC006961.16, AC006581.16, AC007566.1, AC006240.1 , U68299.1, AC004148.1, AC005547.1, U18349.1 , U73644.1, U09744.1, AL132889.2, Z77249.1, AL132885.1 , X06535.1, X77723.1, X91141.1, APOOl 1 1 1.1 , AB029433.1, AB003324.1 , D00170.1, Y17816.1, AU077198.1, AW673639.1, AA315968.1, D59188.1 , T52076.1, AW366774.1 , AA336307.1 , AA337398.1 , AI951709.1 , AA312894.1 , ALl 19477.1 , A A348197.1 , AA460590.1 , T86869.1 , AA095559.1 , AW563125.1, AW563124.1, AW506736.1, AW506735.1, AW506714.1, AW506713.1, AW433456.1, AW330840.1, AW056105.1, AI987345.1, AI976597.1 , AI519245.1, AI511851.1, AI456317.1 , AI455940.1, AA264246.1, AW649858.1, AI239260.1, C93674.1, AW787238.1, AW787237.1, AW728753.1, AW597401.1, AW565183.1, AW374004.1, AW352495.1, AW331243.1, AW286148.1, AI668513.2, AL120839.1, AW021363.1, AI966918.1, AI966929.1, AI964567.1, AI912789.1, AI857189.1, AI756661.1, AI755675.1, AV049065.1, AI746131.1, AI71 1682.1 , AI677124.1, AI667849.1 , AI665080.1, AI637127.1, AI549172.1, AI461446.1, AI461444.1, AI372843.1, AA979929.1, AA979727.1, C72737.1, AA551099.1, ^'AA426143.1, AA406093.1, AA203657.1, C19565.1, R74232.1, F06378.1, T18355.1, AC008579.2, AC021705.4, AC015898.4, AC026989.2, AC020553.3, AC015900.2, ACOl 1789.4, AC022373.1, AC007186.8, ACO 19704.1 , AC007913.1, AL158151.5, AL157785.2, AL355332.1, AC026728.3, AC026712.3, AC026384.2, AC024050.6, AC019207.3, AC020725.3, AC023953.2, AC009593.4, AC019835.1 , AC014673.1, AC008189.2, AC008159.1, AL109836.17, AP001894.1, AP001548.1, AP001544.1, AP001493.1, AP001282.1, AP000906.2, AC012386.9, AC006513.25, AC068979.2, AC063921.4, AC055875.2, AC034211.3, AC008066.3, AC020740.4, AC025942.2, AC025796.2, AC021409.3, AC022788.2, AC025525.2, AC025532.2, AC021373.3, AC022247.2, AC017029.4, AC016685.4, ACOl 1566.3, AC012109.2, AC015727.3, AC010741.3, AC009981.5, AC019821.1, AC007984.3, AC012726.1, AF212833.1, AC017607.1, AC014838.1, AC009366.6, AC006871.1 , AC006803.2, AL354880.3, AL109955.13, AL135939.9, AL355804.2, AL354674.2, AL161790.3, AL157770.2, Z98857.36, AP001993.1, AP001806.1, AP000881.1, AP000841.1, AP000826.1, AP000646.1, AP000621.1,

SEQ ID NO.216 NGO-St-1 14 YS1751/T7 3' NM_005642.1 , AC005618.1, U18062.1, X97999.1, NM_01 1901.1, AFI44562.1, AL121748.6, AL031259.1, Z81455.2, AL009178.4, AB016897.1, AC010227.5, AC008893.4, AC008000.7, AC007172.6, AC004583.1 , AF042091.1 , AL355094.2, AL163282.2, AL031683.1, X15215.1, AB005246.1, AB005230.1, AW304965.1, AI052691.1, AW190867.1, AI709369.1, AW192823.1, AI346408.1, AI818211.1 , AI434577.1, AW264130.1, AA613880.1, AA507377.1, AA4171 13.1, AI804531.1, AI371764.1, AI285611.1, AI675129.1, AI125952.1, AW069225.1 , AI376092.1 , AI366201.1, AA947107.1, AA461518.1, AA063580.1 , AA825152.1, AA776228.1, AA604623.1, AI278875.1 , AI274749.1, AA417019.1, W65333.1, W15503.1, AW512466.1, W61316.1, AI090392.1, AI356847.1, AA97591 1.1, W39724.1, AA037065.1, AW265444.1, AW089083.1, AA838760.1, AA635906.1, AA824551.1, AA602587.1, AI940448.1, AA188912.1 , AW519252.1 , AW860175.1, AW604918.1, T90567.1, AW150510.1, W56065.1, T86870.1, AA508614.1, AL118821.1, R73733.1, AA508722.1, AA886319.1, AA577447.1 , AA380499.1, AA854628.1, AW614384.1, AW607519.1, H84875.1 , F09561.1, AI654286.1, AI287373.1, R30839.1, AA326994.1. T65121.1, R27607.1, AA314905.1, AA946962.1. N87733.1,

AA715623.1, AA412648.1, AA628285.1, C02002.1, AA037079.1, AA894943.1, AA876963.1, AI431981.1, AA380870.1 , AI216614.1, AA585211.1, AA278612.1, AA585402.1, AA460590.1, H85281.1 , AW057744.1, D80075.1, AA794137.1, AA691044.1, AA671025.1, AA794920.1, AW414681.1, AC025419.6, AC015533.4, AC009954.3, AC016357.6, AC021952.4, AL133518.3, AL353600.1, AL031011.20, Z95393.1, AC012600.4, AC012515.11, AC007834.20, AC007623.20, AC021171.3, AC026459.2, AC008952.4, AC010626.4, AC068206.1 , AC027630.4, AC044795.2, AC024399.2, AC012600.3, AC016275.2, AC015826.2, AC009615.2, AC004555.2, AL356212.1, AL137140.5, AL136980.3, AL161900.3, AL139294.1,

SEQ ID NO. 217 NGO-St-114 YS1771/T3 5'

AC005618.1 , X97999.1, NM_005642.1, U18062.1, Z65840.1, Z65839.1, AC004540.1 , ALl 37039.1, AE003630.1, AL132889.2, AL132885.1, AE003646.1 , AE003605.1, AE003412.1, AC004058.1, AC004056.1, Z97180.1, AP001821.1, AC006804.3, AE003510.1 , AFl 36829.1, AC006961.16, AC006581.16, U68299.1, U18349.1, U09744.1, Z77249.1, X06535.1, APOOl 1 1 1.1, AB029433.1, AB003324.1, D00170.1, Y17816.1, AU077198.1, AW673639.1, AA315968.1, D59188.1 , T52076.1 , AA312894.1 , AW366774.1 , AA336307.1 , AA337398.1 , AA460590.1 , AI951709.1 , ALl 19477.1 , AA348197.1 , T86869.1, AA095559.1, AW029214.1, AW877796.1, AW877790.1, AA595371.1, AA252724.1, AA894917.1, AW563125.1, AW563124.1, AW506736.1, AW506735.1, AW506714.1, AW506713.1, AW433456.1-, AW330840.1 , AW056105.1 , AI987345.1 , AI519245.1 , AI511851.1 , AI456317.1 , AI455940.1 , AA264246.1 , AW649858.1 , AI239260.1, C93674.1, AW787238.1, AW787237.1, AW597401.1, AW565183.1, AW352495.1, AW331243.1 ,

AW286148.1, AI668513.2, AW021363.1, AI976597.1, AI966918.1, AI966929.1, AI964567.1, AI756661.1, AI755675.1, AV049065.1, AI746131.1, AI71 1682.1, AI677124.1, AI667849.1, AI665080.1, AI637127.1, AI549172.1, AI461446.1, AI461444.1, AA979929.1 , AA979727.1 , C72737.1, AA426143.1, AA406093.1, C19565.1, R74232.1, T18355.1, AC008579.2, AC021705.4, AC007186.8, AC019704.1, AC007913.1 , AL158151.5, Z98857.36, AC026384.2, AC024050.6, AC019207.3, AC020725.3, AC019835.1 , AC014673.1, AC008189.2, AL109836.17, AP001894.1, AP001863.1 , AP001548.1, AP001544.1, AP001493.1, AP001282.1, AP000906.2, AC012386.9, AC006513.25, AC068979.2, AC009142.4, AC022198.2, AC025796.2, AC021719.3, AC021409.3, AC022788.2, AC021782.2, AC025321.2, AC010929.2, AC025532.2, AC021373.3, AC016685.4, AC012109.2, AC018879.3, AC010741.3, AC012726.1, AC006871.1, AC006803.2, AL354880.3, AL109955.13, AL135939.9, AL355804.2, AL354674.2, AL161790.3, AL157770.2, AP001993.1, AP001806.1, AP000881.1 , AP000826.1, AP000646.1, AP000621.1,

SEQ ID N0.218 NGO-St-114 YS181/T3 5' AC005618.1, X97999.1, NM_005642.1, Ul 8062.1, Z65839.1 , Z65840.1, AC006804.3, AE003512.1, AC002052.8,

AC006961.16, AW673639.1 , D59188.1, AA315968.1, AU077198.1 , T52076.1, AW366774.1, AA348197.1, AA337398.1, AA336307.1 , AI951709.1 , T86869.1 , AA095559.1 , ALl 19477.1 , AA312894.1 , AI239260.1 , AA516747.1 , AC008579.2, AC007913.1, AL158151.5, AC017003.2, AC012386.9, AC068979.2, AC026101.6, AC016639.5, AC016632.4, AC034249.1, AC021373.3, AC017624.1, AC010671.7, AC006871.1 , AC006803.2, APOO 1806.1 , AP000881.1, AP000826.1 , AP000646.1 ,

SEQ ID NO. 219 NGO-St-114 YS191/T7 3' AC005618.1, NM_005642.1, U 18062.1, X97999.1, NM_011901.1, AFl 44562.1. AL009178.4, ABOl 6897.1. AE003618.1, AC007504.3, AB007651.1, AE003764.1, AE003738.1, AF165124.1, AL163258.2, AL078581.11, AL031259.1, Z81455.2, Z82900.1, L77246.I, AP001713.1, AP000178.1, AP000033.1, AB025604.1, AP000266.1, AP000102.1, Z99115.1, M15318.1, Z30211.1, AC012082.6, AC004521.2, AC024750.1, AL121716.16, AL10980I .13, AL008723.8, AL021182.1, ABO 18107.1 , AB005246.1 , AI052691.1, AI346408.1 , AW304965.1 , AWl 90867.1 , AI709369.1 , AWl 92823.1 , AI434577.1 , AI818211.1, AW264130.1. AA613880.1, AA507377.1, AA417113.1. AI675129.1. AI371764.1. AI285611.1, All 25952.1, W65333.1, AI376092.1, AW069225.1, AI366201.1, AI804531.1, AA461518.1, AA063580.1, AA825152.1, AA604623.1, AW860175.1, AW604918.1, AI940448.1, AI278875.1, AA947107.1, W39724.1, AA417019.1, AI274749.1, W15503.1, AA776228.1, AW512466.1, W61316.1, AI090392.1, AI356847.1, AA975911.1, AA037065.1, AA838760.1, AW089083.1, AW607519.1 , AA635906.1 , AA824551.1, AA602587.1 , A W265444.1 , AA 188912.1 , AW519252.1 , T90567.1 ,

AW150510.1, R73733.1, AA508614.1, W56065.1, T86870.1, ALl 18821.1, AA508722.1, AA886319.1, AA577447.1, AA380499.1, AA854628.1, H84875.1, AA314905.1, AW614384.1, F09561.1, AA326994.1, AA412648.1, AI287373.1, R30839.1 , AA037079.1 , R27607.1 , AA380870.1 , T65121.1 , AI654286.1 , N87733.1 , AA715623.1 , AA946962.1 , H85281.1, AA460590.1, AA628285.1, C02002.1, AA894943.1, AA876963.1, AI431981.1, AA585211.1, AI216614.1, AA278612.1, AA585402.1, AA671025.1, D80075.1, AW463162.1, AA381394.1, AA036649.1, AA794137.1, AW057744.1, R52386.1, AA794920.1, AA549454.1, AV100160.1, AC020971.1, AC025419.6, AC064829.3, AC064826.2, AC008835.3, AC013328.5, AC009807.3, AC017738.1, AC018228.1, AL133472.3, AL136980.3, AL353600.1, Z82169.1, AC009757.7, AC060773.2, AC036223.2, AC008825.3, AC027438.2, AC015679.3, AC013782.3, AC016693.4, AC024065.2, ACOl 1647.3, AC013478.3, AC006719.1,

SEQ ID NO. 220

NGO-St-114

YS274/T73'

NM_005642.1, AC005618.1, U18062.1, X97999.1, NM_011901.1, AF144562.1, AE003618.1, AC007172.6, AC005834.1, AE003738.I, AF165124.1, AL163258.2, AL078581.11, AL031259.1, Z81455.2, AP001713.1, AP000178.1, AP000033.1, AP000266.1, AP000102.1, AC004747.2, AC004583.1, AF042091.1, AL163282.2, AL163277.2, AL132879.2, X76272.1, X04112.1, AP001732.1, X15215.1, AP001037.1, AB018107.1, AI434577.1, AI371764.1, AA947107.1, AW519252.1, AA776228.1, AW512466.1, AW304965.1, AW264130.1, AI376092.1, AI274749.1, AI090392.1, AI052691.1, AA824551.1, AA635906.1, AA604623.1, AA507377.1, AA417019.1, AA188912.1, AA063580.1, W61316.1, AW069225.1, AI346408.1, AA825152.1, AI675129.1, AI278875.1, All 25952.1, AA975911.1, AA613880.1, AA602587.1, AA461518.1, AA037065.1, AI285611.1, AW089083.1, AW190867.1, W15503.1, T90567.1, W56065.1, AW265444.1, AI356847.1, T86870.1, AI366201.1, AA838760.1, AA417113.1, AI818211.1, AW192823.1, AI709369.1, AW607519.1, AW150510.1, AA508614.1, AA886319.1, AA577447.1, AA380499.1, AA854628.1, AW860175.1, AW604918.1, H84875.1, AA508722.1, AW614384.1, AI940448.1, AA412648.1, F09561.1, AA314905.1, W39724.1, W65333.1, AA326994.1, AI804531.1, R73733.1, AA037079.1, AI287373.1, ALl 18821.1, AA380870.1, R27607.1. T65121.1, AI654286.1, N87733.1, AA715623.1, AA946962.1, H85281.1, AA628285.1, C02002.1, AA460590.1, AA894943.1, AA876963.1, AA585211.1, AI216614.1, R30839.1, AA278612.1, AA585402.1, AA381394.1, AW463162.1, D80075.1, AA671025.1 , AA794137.1 , AA036649.1 , AW057744.1 , AI431981.1 , R52386.1 , AA794920.1 , AA369696.1 , AA549454.1 , AC02O971.1, AC025419.6, AC020004.1, AC064829.3, AC016547.5, AC008835.3, AC009954.3, ACOl 1791.3, AC016991.2, AC008043.3, AC018408.1, AC017738.1, AL133518.3, AL031011.20, Z95393.1, AC007834.20, AC007623.20, AC067724.3, AC009757.7, AC021171.3, AC064826.2, AC027235.2, AC010515.5, AC008825.3, AC027749.2, AC024483.2, AC015533.4, AC027630.4, AC025229.3, AC046169.1, AC044876.1, AC018737.2, AC024399.2, AC026890.1, AC022020.3, AC024424.2, AC016063.4, AC019157.4, ACOl 1781.4, AC016357.6, AC022518.2, AC013478.3, AC015826.2, AL356212.1, AL355305.2, AL139258.3, AL137140.5, AL161900.3, AL122125.1, AL139294.1, AL022594.18, AP001872.1,

SEQ ID N0.221 NGO-St-114 YS303/T73' NM_005642.1, AC005618.1, U18062.I, X97999.1, NM_011901.1, AF144562.1, AC007172.6, AL121748.6, Z81455.2, Z82900.1, AC004521.2, AC012099.4, AC004583.1, AF042091.1, AL163282.2, Z92812.1, X15215.1, AI052691.1, AW304965.1, AI709369.1, AW190867.1, AI346408.1, AW192823.1, AI818211.1, AW264130.1, AA613880.1, AA507377.1, AI434577.1, AI675129.1, AA417113.1, AI371764.1, AI285611.1, AI125952.1, AI804531.1, AW069225.1, AI376092.1 , AI366201.1 , AA461518.1, AA825152.1 , AA604623.1 , AI278875.1 , AA947107.1 , AA063580.1 , AI274749.1 , AA776228.1, AA417019.1, W15503.1, W65333.1, AW512466.1, AI356847.1, W61316.1, AI090392.1, AA975911.1,

AA037065.1 , W39724.1 , AW089083.1 , AA635906.1 , AA838760.1 , AW265444.1 , AA824551.1, AA602587.1 , AI940448.1 , AA188912.1, AW860175.1, AW604918.1, AW519252.1, T90567.1, AW150510.1, AA508614.1, W56065.1, T86870.1, ALl 18821.1, AA508722.1, AA886319.1, AA577447.1, R73733.1, AA380499.1, AA854628.1, AW614384.1, AW607519.1, H84875.1 , F09561.1, AI654286.1 , AI287373.1 , R30839.1 , AA326994.1 , R27607.1 , T65121.1 , AA946962.1 , AA314905.1 , AA715623.1, N87733.1, AA412648.1, AA628285.1, C02002.1, AA894943.1, AA876963.1, AI431981.1, AA380870.1, AA037079.1, AI216614.1, AA585211.1, H85281.1, AA460590.1, AA278612.1, AA585402.1, AW057744.1, D80075.1, AW414681.1, AA794137.1, AA671025.1, AA691044.1, AA794920.1, A A036649.1, AW280434.1, AI162830.1, AC020971.1, AC015533.4, AC016357.6, AL138817.5, AL133518.3, AL353600.1, AL031011.20, Z82169.1, Z95393.1, SEQ ID N0.222 NGO-St-114 YS305/T7 3'

NM_005642.1, AC005618.1, U18062.1, X97999.1, Z81455.2, AL078462.9, AL034349.3, X15215.1, AI052691.1, AW304965.1, AI709369.1, AW190867.1, AI818211.1, AI346408.1, AW192823.1, AI804531.1, AI434577.1, AW264130.1, AA613880.1, AA507377.1, AA417113.1, AI675129.1, AI371764.1, AI125952.1, AI285611.1, AW069225.1, AI376092.1, AI366201.1, AA461518.1, W65333.1, AA825152.1, AA604623.1, AI278875.1, AA947107.1, AA417019.1, AI274749.1, AA776228.1, AA063580.1, W15503.1, AW512466.1, AI090392.1, W61316.1, W39724.1, AI356847.1, AA975911.1, AW089083.1, AI940448.1, AA635906.1, AA037065.1, AW265444.1, AA824551.1, AA602587.1, AA838760.1, AW519252.1, AA188912.1, W56065.1, T86870.1, AW860175.1, AW604918.1, T90567.1, AA886319.1, AA577447.1, AW150510.1, AA854628.1, AA508614.1, R73733.1, AW614384.1, AA380499.1, F09561.1, AW607519.1, AA508722.1, AI654286.1, ALl 18821.1, H84875.1, AA326994.1, AI287373.1, AA946962.1, AA314905.1, T65121.1, R27607.1, AA412648.1, AA628285.1, C02002.1, R30839.1, N87733.1, AA715623.1, A1216614.1, AA894943.1, AA876963.1, AA380870.1, AA037079.1, AA585211.1, AA278612.1, AA585402.1, AA460590.1, H85281.1, AW057744.1, AI431981.1, D80075.1, AA036649.1, AL031011.20, Z95393.1, AC018923.5, AC036181.2, AC068931.1, AC009440.2, AC027630.4, AC009554.4, AC006286.13, ACOl 1996.3, AC010890.3, AC009528.7, AC007913.1, AL158151.5, AL161785.4,

SEQ ID NO.223 NGO-St-115 YS1641/T73'

L34543.1, L07872.1, L34544.1, NM_015874.1, L08904.1, D14041.1, S63463.1, X17459.1, M81871.1, U60093.1, U60094.1, M81877.1, M81876.1, AE003830.1, AC006578.5, AC005974.1, AC002416.1, AL021578.1, AB024964.1, AB026048.1, AC012397.31, AC012147.7, AC009396.5, AC007270.2, AC007314.3, AF049850.1, AF016494.1, AL032655.1, U23177.1, D25323.1, D90170.1, D90168.1, M64933.1, AI627646.1, AA641661.1, AI401150.1, AW090508.1, AA701607.1, AI962712.1, AI953614.1, AW131544.1, AI829826.1, AW302357.1, AA042864.1, AA640106.1, AI984992.1, AA903408.1, AA483607.1, AA501219.1, AA069672.1, AW249681.1, AW235086.1, AI381502.1, AI619912.1, AI291840.1, AI023923.1, T67414.1, AI580826.1, AI375729.1, AI565611.1, AI334962.1, AI334964.1, AI669755.1, N95392.1, AW425207.1, AW815621.1, AW005947.1, AI982567.1, AI144435.1, AA171398.1, AA788576.1, F33435.1, AI631440.1, AA669918.1, AW815443.1, AW391454.1, AA101255.1, AA676341.1, AW815833.1, AA169326.1, AW815622.1, AW391447.1, AW815635.1, U69195.1, AA101351.1, AA908462.1, AA126685.1,

AW815508.1, AW815506.1, AW249892.1, AW815512.1, AW609613.1, AA044415.1, AA678797.1, AW381515.1, AW474060.1, AW801962.1, AW381537.1, R12509.1, AA156824.1, AW379059.1, AW371260.1, AI720441.1, AW189578.1, T23713.1, AW371378.1, AW381482.1, AW381510.1, AW381496.1, AA705248.1, R19314.1, T70135.1, AW462450.1, AW381476.1, F05151.1, AI206928.1, AW381459.1, AW843169.1, AW610177.1, AW393428.1, AW016196.1, AW009270.1, AA092442.1, AW371229.1, AI658933.1, AI919572.1, AW384329.1, AI708578.1,

AI435870.1, AI274998.1, AA969666.1, AA235124.1, W25228.1, AC006391.7, AC016175.1, AL356136.1, AC009423.2, AC017078.3, AC027239.2, AC024155.2, AC021304.2, AL354733.4, AL135938.7, AL353743.1, AP001998.1, AC022816.9, AC021256.4, AC024322.2, AC017144.1, AL162420.3, AC009192.60, AC068789.3, AC051628.10, AC018995.4, AC012480.4, AC035149.2, AC016591.4, AC040893.1, AC023199.2, AC026808.1, AC022926.2, AC015797.2, ACOl 3664.1, AL356260.1, ALl 18513.14, AL354999.1, AL160035.3, AL159978.2, AL022597.5, AP001532.1, AP001400.1, AP000590.3, Z92865.1, AL022596.1,

SEQ ID NO. 224 NGO-St-115 YS1693/T73'

L34543.1, L07872.1, L34544.1, NM_015874.1, L08904.1, D14041.1, S63463.1, X17459.1, M81871.1, U60093.1, U60094.1, M81877.1, M81876.1, AE003830.1, AC005974.1, AL021578.1, AB024964.1, AB026048.1, ACOl 2397.31, AC012147.7, AC007270.2, AF049850.1, AF016494.1, X56462.1, D25323.1, D90170.1, D90168.1, M64933.1, X59856.1, AA641661.1, AI627646.1, AI962712.1, AA701607.1, AW090508.1, AI40U50.1, AW131544.1, AI953614.1, AI829826.1, A W302357.1 , AA042864.1 , AA640106.1, AI984992.1 , AA903408.1 , AA483607.1 , AA069672.1 , AW249681.1,

AW235086.1, AI381502.1, AI619912.1, AI291840.1, AI023923.1, AA501219.1, T67414.1, AI580826.1, AI375729.1, AI565611.1, AI334962.1 , AI334964.1 , AI669755.1 , N95392.1 , AW815621.1 , AW005947.1 , AI982567.1 , All 44435.1 , AA171398.1, AA788576.1, AW425207.1, F33435.1, AI631440.1, AA669918.1, AW815443.1, AW391454.1, AA101255.1, AA676341.1, AW815833.1, AA169326.1, AW815622.1, AW391447.1, AW815635.1, U69195.1, AA101351.1, AA908462.1, AA126685.1, AW815508.1, AW815506.1, AW249892.1, AW815512.1, AW609613.1, AA044415.1, AA678797.1, AW381515.1, AW474060.1, AW381537.1, R12509.1, AA156824.1, AW379059.1, AW371260.1, AI720441.1, AW189578.1, T23713.1, AW371378.1, AW381482.1, AW381510.1, AW801962.1, AW381496.1, AA705248.1, R19314.1, T70135.1, AW381476.1, F05151.1, AI206928.1, AW462450.1, AW381459.1, AW843169.1, AW610177.1, AW393428.1, AW016196.1, AW009270.1, AA092442.1, AW371229.1, AI658933.1, AI919572.1, AW384329.1, AI708578.1, T79039.1, AW381472.1, F37823.1, AA705236.1, AA895510.1, AC006391.7, AC016175.1, AL356136.1, AC017078.3, AL135938.7, AC016389.2, AC021003.4, AC017144.1, AC016337.1, AL356266.2, AL162420.3, AL161719.6, AL161899.2, AC009192.60, AC068789.3, AC051628.10, AC012480.4, AC022926.2, AC015797.2, AC013664.1, AL137250.3, AL356258.2, AL356260.1, AL354999.1, AL160035.3, AL159978.2, AP00I532.1, AP001400.1. AP000590.3, SEQ ID NO.225 NGO-St-115 YS1713/T73' L34543.1, L07872.1 , L34544.1 , NM_015874.1, L08904.1, D14041.1, S63463.1, X17459.1, M81871.1, U60093.1, U60094.1, M81877.1, M81876.1, L07873.1, AE003830.1, AC005974.1, AL096770.14, AL021578.1, AB024964.1, AB026048.1, AC012397.31, AC010329.3, AC012147.7, AE003603.1, AE002611.1, AC004506.1, AC007270.2, AJ239329.2, D25323.1, AA641661.I, AW090508.1, AI627646.1, AI962712.1, AI953614.1, AI401150.1, AW131544.1, AA701607.1, AW302357.1, AI829826.1, AA501219.1, AI984992.1 , AA042864.1 , AA640106.1, AA903408.1, AA483607.1, AA069672.1, AW249681.1, AW235086.1, AI381502.1, AI619912.1, AI291840.1, AI023923.1, T67414.1, AI580826.1, AI375729.1, AI565611.1, AW425207.1, AI334962.1, AI334964.1, AI669755.1, N95392.1, AW005947.1, AI982567.1, AI144435.1, AA171398.1, AA788576.1, AW815621.1, F33435.1, AI631440.1, AA101255.1, AA676341.1, AA669918.1, AW815443.1, AA169326.1, AW391454.1, AW815833.1, AA101351.1, U69195.1, AA908462.1, AW815622.1, AW391447.1, AW815635.1, AW801962.1, AW249892.1, AA126685.1, AA044415.1, AW815508.1, AW815506.1, AW815512.1, AW609613.1, AA678797.1, AW462450.1, AW381515.1, AW474060.1, AW381537.1, AA156824.1, AW379059.1, AW371260.1, AI720441.1, R12509.1, AWl 89578.1, AW371378.1, AW381482.1, AW381510.1, AW381496.1, T23713.1, T70135.1, AW381476.1, AA705248.1, R19314.1, F05151.1, AW381459.1, AI206928.1, AW843169.1, AW009270.1, H19326.1, AW016196.1, R45471.1, AW084668.1, AI916589.1, AI435870.1, AI274998.1, AI095803.1, AA235I24.1, AA234950.1, W25228.1, AA092442.1, AI352024.1, AW384329.1, AC006391.7, AC016175.1, AL356136.1, AL353636.2, AL135938.7, AL158822.4, AC017144.1, AL162420.3, AC069151.1, AC009192.60, AC068789.3, AC041003.2, AC012480.4, AC053495.3, AC020603.3, AC020726.3, AC012297.3, AC018491.7, AC007532.7, AC013956.1, AC015797.2, AC013664.1, ACO 13097.1, AL356435.1, AL354999.1, AL162418.2, AL160035.3, AL159978.2, AL163639.1, AL139023.1, AP001532.1, AP001400.1, AP000590.3, SEQ ID N0.226 NGO-St-115 YS1732/T73'

L34543.1, L07872.1, L34544.1, NM_015874.1, L08904.1, D14041.1, S63463.1, X17459.1, M81871.1, U60094.1, U60093.1, AE003830.1, AC005974.1 , AC007270.2, AF049850.1, AFO 16494.1, ALl 17207.1, D90170.1, D90168.1, M64933.1, AI627646.1, AI401150.1, AA701607.1, AA641661.1, AI962712.1, AI829826.1, AW131544.1, AI953614.1, AW302357.1, AA042864.1, AW090508.1, AA640106.1, AI984992.1, AA903408.1, AA483607.1, AI291840.1, AW249681.1, AW235086.1, AI381502.1, AI619912.1, AI580826.1, AI375729.1, AA069672.1, AI334962.1, AI334964.1, T67414.1, AI669755.1, AI565611.1, N95392.1, AW005947.1, AI144435.1, AI023923.1, AI982567.1, AA788576.1, F33435.1, AW815621.1, AA501219.1, AA171398.1, AI631440.1, AA101255.1, AA676341.1, AA169326.1, AW815443.1, AW391454.1, AW815833.1, AA669918.1, AA101351.1, AA908462.1, AW815635.1, AW815622.1, AW391447.1, AW425207.1, AW249892.1, AA678797.1, AW815508.1, AA044415.1, AW815506.1, AW815512.1, AW609613.1, AA126685.1, U69195.1, AW381515.1, AWl 89578.1, AW474060.1, AW381537.1, AA156824.1, AA705248.1, AW379059.1, AW371260.1, AI720441.1, AW371378.1, R19314.1, AW381482.1, AW381510.1, T23713.1, AW381496.1, R12509.1, AI206928.1, F05151.1, AW381476.1, AW610177.1, AW393428.1, AW016196.1, AW381459.1, AW843169.1, AI658933.1, AW009270.1, AI919572.1, AW371229.1, T70135.1, AA092442.1, AW801962.1, AW462450.1, AI708578.1, AW384329.1, AW381472.1, AA895510.1, T79039.1, AI401152.1, F37823.1, AC006391.7, AC016175.1, AL356136.1, AC017144.1, AL162420.3, AC068789.3, AC012480.4, AC022263.4, AC021643.7, AC016390.3, AC013664.1, AL354999.1, AL031113.1, AL160035.3, AL159978.2, AL021574.2, AP000590.3, AL020985.1, AL021568.1, SEQ ID N0.227 NGO-St-115 YS1792/T73'

L34543.1, L07872.1, L34544.1, NM_015874.1, L08904.1, D14041.1, S63463.1, X17459.1, M81871.1, U60093.1, U60094.1, M81877.1, M81876.1, AC007270.2, AF049850.1, AF016494.1, D25323.1, D90170.1, D90168.1, M64933.1, AI627646.1, AI401150.1, AA701607.1, AA641661.1, AI962712.1, AI829826.1, AW131544.1, AA640106.1, AI953614.1, AA042864.1 , AW302357.1 , A W090508.1 , AI984992.1 , AA483607.1 , AA903408.1 , AW249681.1, AW235086.1 , AI381502.1, AI291840.1, AI619912.1, AI580826.1, AA069672.1, T67414.1, AI375729.1, A1023923.1, AI334964.1, AI565611.1, AI334962.1, AI669755.1, N95392.1, AW005947.1, AI144435.1, AI982567.1, AW815621.1, AA788576.1, F33435.1, AA501219.1, AA171398.1, AI631440.1, AA101255.1, AA676341.1, AA669918.1, AW815833.1, AW815443.1, AA169326.1, AW391454.1, AA101351.1, AA908462.1, AW815622.1, AW425207.I, AW391447.1, AW815635.1, AW249892.1, AA678797.1, AW815508.1, AA044415.1, AW815506.1, AW815512.1, AW609613.1, AA126685.1, AW381515.1, U69195.1, AW474060.1, AW381537.1, AW189578.1, AA156824.1, AI720441.1, AW379059.1, AW371260.1, AW371378.1, AA705248.1, AW381496.1, AW381482.1, AW381510.1, R12509.1, T23713.1, AW381476.1, R19314.1, AI206928.1, F05151.1, AW381459.1, AW843169.1, AW610177.1, AW393428.1, AW016196.1, AW009270.1, T70135.1, AI658933.1, AA092442.1, AW371229.1, AI919572.1, AW801962.1, AW462450.1, AI708578.1, AW384329.1, AW381472.1, F37823.1, AA895510.1, AA705236.1, T79039.1, AC006391.7, AC016175.1, AL356136.1, AC010633.4, AC015575.5, ACOl 1760.8, AL162420.3, AC068789.3, AC012480.4, AC019214.2, AL354999.1, AL160035.3, ALl 59978.2, AP000590.3, SEQ ID NO.228 NGO-St-115 YS1801/T3,

L07872.1, L34544.1, L34543.1, NM_015874.1, L08904.1, D14041.1, S63463.1, X17459.1, M81871.1, L07873.1, U60094.1, U60093.1, X59130.1, X59129.1, M81869.1, M81874.1, M81870.1, AB003695.1, M81873.1, M81872.1,

M81875.1, AF085173.1, AE003646.1, AE003411.1, AF047659.1, ACOl 1288.3, AC002338.2, AC007729.2, AE003662.1, AC006978.2, AC007082.4, AC006263.1 , AF003130.1 , Y08501.1, U80814.1 , X66728.1 , X65871.1 , AJ007973.1 , X58393.1, M94383.1, AE002611.1, AF223391.1, AC024864.1, AC024206.1, AC012329.3, AF104919.1, AL355836.1, AL157756.2, AL161587.2, AL161492.2, AL132964.2, AL137898.1, AL132962.1, AL035581.1, Z93385.1, Z81086.1, AL035445.4, U70855.1, X96762.1, AL031135.1, U69195.1, AW462450.1, AI32575I.1, AA935398.1, AW084668.1, AI916589.1, AW801962.1, T79039.1, T70135.1, AA501219.1, W25228.1, AI435870.1, AI274998.1, AI095803.1, AA235124.1, AA234950.1, R37405.1, AA081973.1, AA101254.1, H19326.1, AW239382.1, AW090508.1, R16902.1, F04242.1, AA969666.1, R45471.1, AA232981.1, AI352024.1, AW384329.1, T19153.1, AA233367.1, AI953614.1, R44578.1, F01398.1, AA641661.1, T23712.1, AW384317.1, AA101350.1, AI962712.1, AW425207.1, AW249681.1, AI627646.1. AI401150.1, AA171575.1, AW131544.1, R19314.1, AA817421.1, AI142713.1, AA736032.1, R71133.1, AW760949.1, AJ394324.1, AW418568.1, AW221760.1, AW093987.1, AW043304.1, AI995809.1, AV200012.1, AV198387.1, AV191304.1, AI779257.1, C65393.1, D73771.1, D69291.1, D68255.1, D37730.1, AL356136.1, AC006391.7, AC019747.1, AC015644.3, AC015641.3, AC068980.2, AC021871.8, AC063967.1, AC024734.3, AC024447.2, AC006927.22, AC017011.3, AC010780.3, AC025099.1, AC010147.4, AC013569.3, AC017470.1, AC006714.2, AL353636.2, AL158822.4, AP001377.1, AC012598.9, AC055764.3, AC067725.2, AC025573.4, AC024560.5, AC036183.2, AC055790.2, AC069123.1, AC069026.1, AC013610.2, AC068491.1, AC024084.2, AC008751.4, AC008749.4, AC005077.2, AC008267.3, AC027094.2, AC034098.1, AC025889.2, AC016462.3, AC027268.1, AC025317.2, AC018681.5, AC023815.2, AC018491.7, AC013504.2, AC013097.1, AC006904.2, AC006900.1, AC006719.1, AL138904.2, AL354990.1, AP000904.2, AP001455.1, AP000706.1, AL009206.1,

SEQ ID N0.229

NGO-St-115

YS1801/T73'

L34543.1, L07872.1, L34544.1, NM_015874.1, L08904.1, D14041.1, S63463.1, X17459.1, M81871.1, U60093.1, U60094.1, M81877.1, M81876.1 , AE003627.1 , AC005734.1, AE003830.1, AC005974.1, AL021578.1, AB024964.1, AB026048.1, AC012397.31, AC012147.7, AC006729.1, AE003603.1, AE003578.1, AC008261.3, AC017118.3, AC007270.2, AC005149.1, AF068710.1, AE000051.1, AJ239329.2, D25323.1, AW090508.1, AI627646.1, AA641661.1, AI962712.1, AI953614.1, AI401150.1, AW131544.1, AA701607.1, AW302357.1, AI829826.1, AA501219.1, AI984992.1, AA042864.1, AA640106.1, AA903408.1, AA483607.1, AA069672.1, AW249681.1, AW235086.1, AI381502.1, AI619912.1, AI291840.1, AI023923.1, T67414.1, AI580826.1, AW425207.1, AI375729.1, AI565611.1, AI334962.1,

AI334964.1, AI669755.1, N95392.1, AW005947.1 , AI982567.1 , AI144435.1, AA171398.1, AA788576.1, AW815621.1, F33435.1, AI631440.1, AA101255.1, AA676341.1, AA669918.1, AW815443.1, AA169326.1, AW391454.1, AW815833.1, AA101351.1, U69195.1, AA908462.1, AW815622.1, AW391447.1, AW815635.1, AW801962.1, AW249892.1, AA126685.1, AA044415.1, AW815508.1, AW815506.1, AW815512.1, AW609613.1, AA678797.1, AW462450.1, AW381515.1, AW474060.1, AW381537.1, AA156824.1, AW379059.1, AW371260.1, AI720441.1, R12509.1,

AWl 89578.1, AW371378.1, AW381482.1, AW381510.1, AW381496.1, T23713.1, T70135.1, AW381476.1, AA705248.1, R19314.1, F05151.1, AW381459.1, AI206928.1, AW843169.1, AW009270.1, AW016196.1, AW084668.1, AI916589.1, AI435870.1, AI274998.1, AI095803.1, AA235124.1, AA234950.1, W25228.1, AA969666.1, AA092442.1, F04242.1, R45471.1, AW384329.1, AC006391.7, AC016175.1, AL356136.1, AC010631.4, AC025727.1, AC018490.4, AC020100.1, AL135938.7, AC018869.3, AC017144.1, AL138767.6, AL162420.3, AC009192.60, AC068789.3, AC025573.4, AC036183.2, AC041003.2, AC012480.4, AC025763.2, AC021089.2, ACOl 1454.3, AC010533.3, AC008785.3, AC064816.1, ACOl 1124.3, AC055769.1, AC019311.4, AC027284.1, AC018411.3, AC019202.3, AC007532.7, AC013956.1, AC020022.1, AC015797.2, AC013664.1, AC010694.2, AC006754.1, AL139235.6, AL354999.1, AL160035.3, AL159978.2, AP0019O4.1, APOO 1532.1, APOO 1400.1, AP000590.3,

SEQ ID NO.230

NGO-St-115

YS276/T73'

L34543.1, L07872.1, L34544.1, NM_015874.1, L08904.1, D14041.1, S63463.1, X17459.1, M81871.1, U60094.1, U60093.1, M81877.1, L07873.1, AE003830.1, AC005974.1, AL021578.1, AB024964.1, AB026048.1, AC012397.31, AC012147.7, AE002611.1, AC007270.2, U64857.1, AF049850.1, AF016494.1, D90170.1, D90168.1, M64933.1, AA641661.1, AI627646.1, AW090508.1, AI962712.1, AI401150.1, AW131544.1, AA701607.1, AI953614.1, AI829826.1, AW302357.1, AA042864.1, AI984992.1, AA640106.1, AA903408.1, AA501219.1, AA483607.1, AA069672.1, AW249681.1, AW235086.1, AI381502.1, AI619912.1, AI291840.1, AI023923.1, T67414.1, AI580826.1, AI375729.1, AI565611.1, AI334962.1 , AI334964.1 , AI669755.1 , N95392.1 , AW815621.1 , A W425207.1 , AW005947.1 , AI982567.1 , AI144435.1_> AA171398.1, AA788576.1, F33435.1, AI631440.1, AW815443.1, AA669918.1, AW391454.1, AW815833.1, AA101255.1, AA676341.1, AA169326.1, AW815622.1, AW391447.1, AW815635.1, AA101351.1, AA908462.1, U69195.1, AA126685.1, AW815508.1, AW815506.1, AW815512.1, AW609613.1, AW249892.1, AA044415.1, AA678797.1, AW801962.1, AW381515.1, AW474060.1, R12509.1, AW381537.1, AA156824.1, AW379059.1, T23713.1, AW371260.1, AI720441.1, AW189578.1, AW371378.1, AW381482.1, AW381510.1, AW381496.1, AW462450.1, AA705248.1,R19314.1,F05151.1,T70135.1,AW381476.1,AI206928.1,AW381459.1,AW843169.1,AW610177.1, AW393428.1, AW016196.1, AA092442.1, AW009270.1, AW371229.1, AI658933.1, AI919572.1, H19326.1, AW084668.1,AI916589.1,R16902.1,AA235124.1,AI708578.1,AW384329.1,AC006391.7,AC016175.1,AL356136.1, AC017078.3, AL135938.7, AC017144.1, AL162420.3, AC009192.60, AC068789.3, AC051628.10, AC012480.4, AC053495.3, AC022926.2, AC018491.7, AC015797.2, AC013664.1, AC013097.1, AC006915.1, AL356260.1, AL354999.1, AL160035.3, AL159978.2, AP001532.1, AP001400.1, AP000590.3,

SEQIDNO.231 NGO-St-115 YS302/T73'

L34543.1,L07872.1,L34544.1,NM_015874.1,L08904.1,D14041.1,S63463.1,X17459.1,M81871.1,U60093.1, U60094.1, M81877.1, M81876.1, AC008408.5, ACOl 1422.2, AE003830.1, AC006356.3, AC005974.1, AL021578.1, AB024964.1, AB026048.1, AC012397.31, AC012147.7, AE003578.1, AC007115.1, AC007270.2, U66059.1, AF030179.1, AC005149.1, AF049850.1, AF016494.1, AL133376.6, D25323.1, D90170.1, D90168.I, U07978.1, M64933.1, AI627646.1, AA641661.1, AW090508.1, AI401150.1, AI953614.1, AI962712.1, AW131544.1, AA701607.1, AI829826.1, AA042864.1, AW302357.1, AA640106.1, AI984992.1, AA903408.1, AA483607.1, AW249681.1, AW235086.1, AI381502.1, AA501219.1, AA069672.1, AI619912.1, AI291840.1, AI023923.1, T67414.1, AI580826.1, AI375729.1, AI565611.1, AI334962.1, AI334964.1, AI669755.1, N95392.1, AW005947.1, All 44435.1, AW815621.1, AI982567.1, AA788576.1, AA171398.1,AW425207.1,F33435.1,AI631440.1,AA669918.1,AW815443.1,AA101255.1,AW391454.1,AA676341.1, AW815833.1,AA169326.1,AW815622.1₎AA101351.1,AW391447.1,AW815635.1,AA908462.1,AA126685.1, AW815508.1, AW249892.1, AW815506.1, AW815512.1, AW609613.1, U69195.1, AA044415.1, AA678797.1, AW381515.1, AW474060.1, AW381537.1, AA156824.1, R12509.1, AW801962.1, AW379059.1, AW371260.1, AI720441.1, AW189578.1, AW371378.1, T23713.1, AW381482.1, AW381510.1, AW381496.1, AA705248.1, R19314.1, AW381476.1, F05151.1, AW462450.1, AI206928.1, T70135.1, AW381459.1, AW843169.1, AW009270.1, AA092442.1, AW610177.1,AW393428.1,AW016196.1,AW371229.1,AI658933.1,AI919572.1,R16902.1,H19326.1,AI708578.1, AA235124.1, AA969666.1, AW384329.1, R45471.1, AC006391.7, AC016175.1, AL356136.1, ACOl 1340.3, AC017144.1, AL162420.3, AC009192.60, AC068789.3, AC012480.4, AC027785.2, AC025508.2, AC012346.3, AC027284.1, AC009659.3, AC021978.4, AC013448.3, AC020022.1, AC015797.2, AC010694.2, AL137160.4, AL354999.1, AL160035.3, AL159978.2, AP001532.1, AP001400.1, AP000590.3,

SEQ ID N0232 NGO-St-115 YS323/T73' L34543.1.L07872.1, L34544.1,NM_015874.1, L08904.1, D14041.1, S63463.1.X17459.1, M81871.1, U60093.1, U60094.1, M81877.1, M81876.1, AE003830.1, AC005974.1, AC007270.2, AF049850.1, AF016494.1, D25323.1, D90170.1, D90168.1, M64933.1, AA641661.I, AI627646.1, AA701607.1, AI962712.1, AW131544.1, AI401150.1, AW090508.1, AI953614.1, AI829826.1, AA042864.1, AW302357.1, AA640106.1, AI984992.1, AA903408.1, AW249681.1, AW235086.1 , AI381502.1 , AI619912.1 , AI291840.1 , AA483607.1 , AI580826.1 , AA069672.1 , AI375729.1 , AA501219.1, T67414.1, AI565611.1, AI023923.1, AI334962.1, AI334964.1, AI669755.1, N95392.1, AI982567.1,

AW005947.1,AI144435.1,AW815621.1,AA788576.1,F33435.1,AA171398.1,AI631440.1,AW815443.1,AA101255.1, AA676341.1, AW391454.1, AW425207.1, AW815833.1, AA169326.1, AA669918.1, AW815622.1, AW815635.1, AW391447.1,AA101351.1,AA908462.1,AW815508.1,AW815506.1,AW249892.1,AW815512.1,AW609613.1, U69195.1,AA126685.1,AA044415.1,AA678797.I,AW381515.1,AW189578.1,AW474060.1,AW381537.1, AA156824.1, R12509.1, AW379059.1, AW371260.1, AI720441.1, AA705248.1, AW371378.1, T23713.1, AW381482.1, AW381510.1,AW381496.1,F05151.1,AW381476.1,AI206928.1,R19314.1,AW801962.1,AW381459.1,T70135.1, AW843169.1, AW610177.1, AW393428.1, AW016196.1, AI658933.1, AA092442.1 , A W462450.1 , AW009270.1, AI919572.1, AW371229.1, AW384329.1, AI708578.1, AW381472.1, AA895510.1, F37823.1, R45471.1, R16902.1, AC006391.7, AC016175.1, AL356136.1, AC017144.1, AL162420.3, AC068789.3, AC012480.4, AC013664.1, AL354999.1, AL160035.3, AL159978.2, AP000590.3,

SEQ ID N0.233 NGO-St-115 YS372/T73' L34543.1,L07872.1,L34544.1,NM_015874.1,L08904.1,D14041.1,S63463.1,X17459.1,M81871.1,U60093.1,

U60094.1, M81877.1, M81876.1, AE003830.1, AC005974.1, AC012397.31, AC007270.2, AF049850.1, AF016494.1, D25323.1,D90170.1,D90168.1_JM64933.1,AA641661.1,AI627646.1,AA701607.1,AI962712.1,AW131544.1, AW090508.1, AI953614.1, AI401150.1, AI829826.1, AA042864.1, AW302357.1, AA640106.1, AI984992.1, AA903408.I, AA483607.1, AW249681.1, AW235086.1, AI381502.1, AA069672.1, AI619912.1, AI291840.1, AI580826.1, T67414.1, AI023923.1, AA501219.1, AI375729.1, AI565611.1, AI334962.1, AI334964.1, AI669755.1, N95392.1, AW005947.1,

AI144435.1,AI982567.1,AW815621.1,AA788576.1,F33435.1,AA171398.1,AW425207.1,AI631440.1,AA101255.1, AW815443.1,AA676341.1,AW391454.1,AA669918.1,AA169326.1,AW815833.1,AW815622.1,AA101351.1, AW391447.1,AW815635.1,AA908462.1,U69195.1,AW815508.1,AW249892.1,AW815506.1,AW815512.1, AA126685.1, AW609613.1, AA044415.1, AA678797.1, AW381515.1, AW474060.1, AW381537.1, AWl 89578.1, R12509.1, AA156824.1, AW379059.1, AW371260.1, AI720441.1, AW371378.1, AA705248.1, T23713.1, AW381482.1, AW381510.1, AW381496.1, AW381476.1, R19314.1, T70135.1, F05151.1, AI206928.1, AW801962.1, AW381459.1, AW843169.1, AW462450.1, AW610177.1, AW393428.1, AW016196.1, AW009270.1, AA092442.1, AW371229.1, AI658933.1 , AI919572.1 , AW384329.1 , AI708578.1 , A W381472.1 , F37823.1 , T79039.1 , AA895510.1 , AA705236.1 , AC006391.7, AC016175.1, AL356136.1, AC017144.1, AL162420.3, AC009192.60, AC068789.3, AC012480.4, AC010552.3, AC023549.2, AC022931.3, AC022391.2, AL354999.1, AL160035.3, AL159978.2, AP001005.1, AP000590.3,

SEQ ID N0.234 NGO-St-115 YS406/T73'

L34543.1, L07872.1, L34544.1, NM_015874.1, L08904.1, D14041.1, S63463.1, X17459.1, M81871.1, U60093.1, U60094.1, M81877.1, AE003830.1, AC005974.1, AC007270.2, AF049850.1, AF016494.1, AF035530.1, D25323.1, D90170.1, D90168.1₎ M64933.1, AA701607.1, AA641661.1, AI627646.1, AI962712.1, AI401150.1, AW131544.1, AW090508.1, AI953614.1, AI829826.1, AA042864.1, AW302357.1, AA640106.1, AI984992.1, AA903408.1,

AW249681.1, AW235086.1, AI381502.1, AA483607.1, AI619912.1, AI291840.1, A A069672.1, AI580826.1, T67414.1, AI375729.1 , AI023923.1 , AI565611.1, AI334962.1 , AI334964.1 , AA501219.1 , AI669755.1 , N95392.1 , AW005947.1 , AI144435.1, AI982567.1, AW815621.1, AA788576.1, F33435.1, AA171398.1, AI631440.1, AA101255.1, AA676341.1, AW815443.1, AA169326.1, AW425207.1, AA669918.1, AW391454.1, AW815833.1, AA101351.1, AW815622.1, AA908462.1, AW815635.1, AW391447.1, AW249892.1, AW815508.1, AA044415.1, AW815506.1, AA678797.1, AA126685.1, AW815512.1, AW609613.1, U69195.1, AW381515.1, AW474060.1, AW381537.1, AWl 89578.1, AA156824.1, AW379059.1, AW371260.1, AI720441.1, AW371378.1, AW381482.1, AW381510.1, AW381496.1, R12509.1, AA705248.1, T23713.1, AW381476.1, AI206928.1, F05151.1, AW381459.1, R19314.1, AW843169.1, T70135.1, AW801962.1, AW610177.1, AW393428.1, AW016196.1, AW462450.1, AI658933.1, AW009270.1, AA092442.1, AW371229.1, AI919572.1, AI708578.1, AW384329.1, A W381472.1, F37823.1, AI274998.1, AA235124.1, W25228.1, AC006391.7, AC016175.1, AL356136.1, AC022173.4, AC009377.5, AC017144.1, AL162420.3,

SEQ ID NO.235 NGO-St-116 YS1651 T3 5'

M22382.1, NM_002156.1, M34664.1, X54793.1, M22383.1, X55023.1, X53584.1, X53585.1, AC006511.5, M34661.1, AF071216.1, M34660.1, M34663.1, M34662.1, AL096817.12, M34562.1, AJ250915.1, AF227510.1, AL163248.2, U68562.1, D16852.1, AF040153.1, U87959.1, AF121264.1, U94594.1, U38963.1, AL031663.1, Y15783.1, AJ235272.1, AF103898.1, AF103897.1, X70868.1, AF075440.1, U96733.1, X56034.1, U20804.1, AJ249625.1, Z66568.2, U72247.1, AJ130947.1, AJ 130877.1, APOOl 297.1, D50609.1, Z11547.1, Z12114.1, AF165812.1. X57520.1. X70867.1, AE003485.1, AF031929.1, U17244.1, Z49766.1, M33301.1, X99341.1, AF192796.1, LI 1390.2, L10917.1. Z12115.1, Z11546.1, L21006.1, L21008.1, L21007.1, X62578.1, AF076436.1, AF076435.1, AF076434.1, AF076433.1, AC006229.17, AF195273.1, AF062533.1, U45241.1, AF085694.1, AF003957.1, M98257.1, Z15160.1, X68263.1, AE003610.1, U40419.1, AC004721.1, M35600.1, AA186560.1, AA315828.1, AA190505.1, AA101281.1, AA196456.1, AA355063.1, AA220969.1, ALl 18805.1, AW107008.1, AA313717.1, AA211155.1, AW246390.1, AI133536.1, AA130735.1, AA307775.1,

AI956302.1, AI526655.1, AA186742.1, AI876755.1, AI789073.1, AA147407.1, AA314982.1, AA066721.1, AA083150.1, AI049243.1, AA153935.1, AI788452.1, AA314648.1, AW211098.1, All 19103.1, AA073178.1, AI882194.1, AI875338.1, AA182547.1, AA179642.1, AA333493.1, AI663294.1, AA355152.1, AA308780.1, F06480.1, AW012138.1, AAl 14125.1, AA181753.1, AW258808.1, AI891951.1, AI316009.1 , AI787944.1 , AI931393.1, AW246054.1, AW045067.1, AA218257.1, AW319430.1, AA407305.1, AA361120.1, AW213301.1, AW259849.1, AW012331.1, AA415608.1,

AI874815.1, AA375302.1, AA199785.1, AJ398447.1, AW229516.1, AA341141.1, AA355963.1, AW259968.1, R58784.1, AW258893.1, AA355415.1, C89446.1, AA314047.1, AA184322.1, AA087600.1, AA413960.1, AW260552.1, W41752.1, AA333568.1, AA793425.1, AA215942.1, AW773213.1, ALl 17921.1, AA026155.1, AW784168.1, AA158695.1, AA346637.1, AI980165.1, AI524820.1, N84903.1 , AA537973.1, AI709970.1, AA027070.1, N88468.1, AA409877.1, AA096333.1, AA067313.1, AA530483.1, AA301042.1, AA093803.1, AW803755.1, AW803695.1, AC024884.6,

AC032001.2, AF252831.1, AF252830.1, AF202031.1, AF189745.1, AC027473.2, AL354869.1, AL160258.3, AC020550.3, AF260011.1, AC008821.4, AC008840.3, AC008511.4, AC009077.5, AC016517.4, AP001561.1, AP000641.1, AL121980.6, AC010746.3, AC018953.5, AC007521.11, AC017670.1, AC023505.8, AC009800.6, AC024321.3, AC053499.2, AC009702.4, AC027301.3, AC007716.2, AC024986.2, AC006440.8, AC013618.3, AC026185.1, AC018811.3, AC018494.3, AC013802.2, AL138997.6, AL158054.5, AL139821.2, AL138683.2, AC068767.2, AC068639.3, AC068036.3, AC044841.2, ACOl 1008.3, AC007996.3, AC010275.4, AC068576.1, AC027239.2, AC023275.2, AC021876.3, AC055878.1, AC047627.1, AC044783.1, AC008709.2, AC015911.4, AC013744.3, AC022484.3, ACOl 1693.4, AC018862.3, AC019325.3, AC023375.2, AC009939.2, AC021304.2, AC019197.3, AC022069.1, AC017455.1, AL356107.2, AL121996.5, AL356059.1, AL133227.11, AL353707.1, AL161661.1, AP001998.1, APOOl 197.1, AP001096.2,

SEQ ID N0.236 NGO-St-116 YS1651/T73' NM_002156.1, M22382.1, M34664.1, AJ250915.1, AC006511.5, AC004220.1 , X53585.1, X54793.1, X53584.1 , M22383.1, M34663.1 , AF227510.1, AL163248.2, U68562.1 , X55023.1, M34661.1, M34662.1, M34660.1, AL096817.I2, M34562.1, AF069298.1 , AL161494.2, L36035.1. Z12114.1, Zl 1546.1, X02895.1, AF197942.1. Z81065.1, U58764.1, AE003531.1, AEOOl 1 12.1, AE000808.1, AL021497.1 , Z99568.2, Z81571.1, U13189.1, X54512.1, U01086.1, M74012.1, L21007.1, M10383.1 , AC007320.2, NM_006915.1, AC004097.1, U23174.1, U67599.1, U67506.1, AL133396.1, Z35719.1, Z82274.1, Z82253.1, Z70272.1, AJ007590.1, AA550823.1, AA083219.1, AA630404.1 , AI832486.1, AA826248.1 , AW102810.1, AW131404.1, AI926703.1, AW004895.1, AI922978.1, AI827012.1, AI619432.1, AI627740.1, AI690942.1 , AI570191.1, AW276236.1, AI924961.1, AI961421.1, AI956156.1, AI885544.1, AI609776.1, AW469262.1 , AI678654.1 , AI985757.1, AI683208.1, AW276334.1, AA769669.1, AW304695.1, AW820138.1 , AWl 17832.1, AW177563.1 , AW780292.1, AW439804.1, AI818534.1, AW071129.1 , AI801296.1, AI571107.1, AW246607.1, AW573149.1, AW513062.1, AA448453.1, AW161433.1, AI565115.1, AA565131.1, AW675607.1, AI221866.1, AI521493.1, AA102391.1, AW410099.1, AI075218.1 , AA629677.1, AI325539.1, AA564099.1, AW572206.1, AI609928.1, AI189669.1, AW157717.1, AA595763.1, AA600146.1, AI612727.1 , AI217363.1, AW419186.1, AA167738.1 , AI983518.1, AA603962.1, AW246632.1, AI582821.1, AW516994.1, AA948019.1, AW156968.1, AW104022.1, AI744383.1, AW513837.1, AW084921.1, AA617879.1 , AA515520.1, AW085863.1, AI573195.1, AA609838.1, AI569189.1, AW23641 1.1, AW192162.1, AI285386.1, AW572335.1, AW674312.1, AW068921.1 , AI284071.1, AW674564.1, AI565483.1 , AI335167.1 , AA847770.1 , AA577528.1 , AA218869.1 , AA 181826.1 , AA978125.1 , AA583474.1 , AI023089.1 , AA605126.1, AA479788.1, AA130632.1, AC010746.3, AC024884.6, AC027473.2, AL136079.3, AC032001.2, AC026299.2, AL138760.4, AC063980.1, AF252831.1, AF252830.1, AF202031.1, AF189745.1, AF26001 1.1, AC008821.4, AC008840.3, AC008511.4, AL354869.1 , AL137180.3, AL160258.3, AC016517.4, AP001561.1, AP000641.1,

AC026746.3, AC016645.3, AC026750.2, AC026809.1, AP000799.1, AC006909.1, AC053468.1, AL121980.6, Z98856.1, AC026022.2, AC018406.2, AL022344.1, Z95399.9, Z99775.8, AL022281.20, AL020986.14, Z92852.20, AL021576.1, AL022279.5, AL021149.3, Z92855.3, Z92851.5, Z92821.1, Z99005.1, Z95312.1, AL022301.1, AL008880.1, Z98876.1, AL022283.1, Z98871.1, AL008876.1, Z98869.1, Z98868.1, Z92862.1, Z92861.1, Z99275.1, Z93240.1, Z92856.1, Z92854.1 , Z93245.1 , Z93243.1 , AL022474.1 , AL021347.1 , Z96049.1 , AL022276.1 , AC026640.2, AC023549.2, AC005308.6, AC016770.4, AL355572.1, AL109808.2,

SEQ ID N0.237 NGO-St-116 YS1701/T3 5'

M22382.1 , NM_002156.1 , M34664.1, AC006511.5, M22383.1, X55023.1 , X54793.1, X53584.1, AF071216.1, X53585.1, M34661.1, M34660.1, M34663.1, M34562.1, AJ250915.1, M34662.1, AF227510.1, AL163248.2, AL096817.12, U68562.1 , D16852.1, AF040153.1, AL031663.1. U87959.1, AF121264.1, Y15783.1, AJ235272.1, X70868.1, AF075440.1, U96733.1, X56034.1, AJ249625.1, AP001297.1, Z11547.1, Z12114.1, AF1658I2.1 , X70867.1 , AE003485.1, AF031929.1, X99341.1 , AF192796.1, LI 1390.2, L10917.1, Z12115.1, Zl 1546.1, L21006.1, L21008.1, L21007.1, AC006229.17, AF195273.1, AF062533.1 , AFl 03898.1, AF103897.1, U23170.1, M98257.1 , Z15160.1, X68263.1, AC002304.3, AC002334.2, AE003610.1, AE001965.1, AC005082.2, U40419.1, U01771.1, AC005908.1, U39703.1, AC004721.1, AEOOl 104.1, AL163264.2, ALl 10498.1, AL078623.28, Z94056.1, Z66568.2, U24679.1, AP001719.1, M80811.1, AP000467.1, D50609.1, M35600.1, AA196456.1 , AA190505.1, AA220969.1, AL118805.1 , AI133536.1, AA307775.1, AA315828.1, AW246390.1, AA186742.1, AA313717.1, AA186560.1 , AAI30735.1, AI526655.1, AA083150.1 ,

AI956302.1, AA101281.1, AI876755.1, AW107008.1, AA314648.1, AI789073.1 , AA153935.1, AI788452.1, AA147407.1 , AI049243.1, AA308780.1, AA179642.1, AI119103.1, AA066721.1, AI882194.1, AA181753.1, AAl 14125.1 , AI663294.1, AW012138.1, AW246054.1, AA073178.1, AI875338.1, AI891951.1, AW21 1098.1, AI787944.1, AW045067.1, AA333493.1, AI316009.1, AA375302.1, AW319430.1, AI931393.1, AA341141.1, AW258808.1, AW259849.1, AA211 155.1, AI874815.1, AW213301.1 , AA407305.1, AA361 120.1, AW012331.1, AA355063.1, AA415608.1,

AW229516.1, AA333568.1 , AA218257.1 , C89446.1, AW259968.1, AW260552.1, AW258893.1, W41752.1, R58784.1, AA413960.1, AA087600.1, AA314047.1, AA346637.1, AA314982.1, N88468.1, AA 182547.1 , N84903.1, AA215942.1, AA355152.1, F06480.1 , AJ398447.1, AA026155.1, AA355415.1, AA301042.1, AW784168.1, AA158695.1 , AW773213.1, AI980165.1, AA184322.1. N87641.I , AA096333.1, AA093803.1, AA793425.1, AW803755.1, AW803695.1, AA223110.1, AA199785.1, AA355963.1, ALl 17921.1, AA091450.1, AA248806.1, AA196711.1, AU077229.1 , AW645070.1 ,

AC024884.6, AC032001.2, AF252831.1, AF252830.1, AC027473.2, AF202031.1, AF189745.1, AL354869.1, AC020550.3, AF260011.1, AL160258.3, AC008821.4, AC008840.3, AC008511.4, AC009077.5, AL121980.6, AC016517.4, AP001561.1, AP000641.1, AC018953.5, AC007521.1 1 , AC017670.1, AC009800.6, AC024321.3, AC053499.2, AC009702.4, AC027301.3, AC007716.2, AC024986.2, AC006440.8, AC013618.3, AC013802.2, AL080249.16, AL138997.6, AL158054.5, AL158800.1, AL139821.2, AL138683.2, AC021068.8, AC068767.2, AC068639.3, AC044841.2, AC069050.1, AC034292.2, ACOl 1008.3, AC007996.3, AC068576.1, AC023275.2, AC021876.3, AC055878.1, AC044783.1, AC008709.2, AC013744.3, AC022484.3, ACOl 1693.4, AC018862.3, AC019325.3, AC023375.2, AC009939.2, AC016289.3, AC019197.3, AC022069.1, AC017455.1, AL121996.5, AL133227.11, AL353707.1, AL161661.1, Z92863.2, APOOl 197.1,

SEQ ID NO.238

NGO-St-1 16

YS1701/T7 3'

M22382.1, NM_002156.1 , M34664.1, AJ250915.1 , AC006511.5, M22383.1 , X53585.1, X54793.1, X53584.1, AC004220.1, M34663.1, AL096817.12, AF227510.1, ALl 63248.2, X55023.1, U68562.1, M34662.1, M34661.1, M34660.1, M34562.1, AF025468.2, AF069298.1, AL161494.2, L36035.1, AE001727.1, X02895.1, AF240627.1, AF197942.1, AL109763.2, U58764.1, AC024848.1, ACOl 1594.8, AEOOl 112.1, AE000808.1, Z81571.1, X79205.1, AP000183.1, AP000038.1, AP000107.1, M74012.1, AC007320.2, ACOl 1592.5, AC008122.15, U67599.1, U67521.1, AL161505.2, AL133396.1, Z35719.1, ALl 18497.9, Z82253.1. Z70272.1, AL021367.1, APOOl 115.1, AA630404.1,

AA826248.1, AI832486.1, AI609776.1, AI926703.1, AI627740.1, AA769669.1, AW004895.1, AI619432.1, AI570191.1, AW246607.1, AW131404.1, AI818534.1, AI922978.1, AI827012.1, AW102810.1, AI690942.1, AW573149.1, AA565131.1, AI961421.1, AI221866.1, AW276236.1, AI924961.1, AI956156.1, AA448453.1, AW177563.1, AI683208.1, AW469262.1, AI885544.1, AW410099.1, AI985757.1, AI678654.1, AA564099.1, AA102391.1, AI325539.1, AI189669.1, AW304695.1, AW780292.1, AA595763.1, AW071129.1, AW157717.1, AW276334.1, AI217363.1, AW439804.1, AWl 17832.1, AA629677.1, AA600146.1, AA603962.1, AWl 56968.1, AW246632.1, AI801296.1, AI582821.1, AAl 67738.1 , AI609928.1 , AI571107.1 , AA948019.1, AW513062.1 , AA609838.1 , AW675607.1 , AA515520.1 , AI565115.1, AI285386.1, AA617879.1, AW068921.1, AI521493.1, AI284071.1, AA847770.1, AI335167.1, AA577528.1, AA218869.1, AA181826.1, AW572206.1, AA978125.1, AA583474.1, AI023089.1, AW419186.1, AI075218.1, AI983518.1, AA605126.1, AI612727.1, AW104022.1, AW084921.1, AA774671.1, AA479788.1, AA130632.1, AW516994.1, AW513837.1, AI744383.1, AA970442.1, AA196514.1, AI168478.1, AW085863.1, AI573195.1, AA219578.1, AA164508.1, AW236411.1, AW192162.1, AW572335.1, AA133938.1, AW674312.1, AC010746.3, AC024884.6, AC027473.2, AC032001.2, AL136079.3, AL138760.4, AC026299.2, AL354869.1, AC063980.1, AF252831.1, AF252830.1, AF202031.1, AF189745.1, AC008821.4, AC008840.3, AC008511.4, AL137180.3, AL160258.3, AF260011.1, AC026746.3, AC016645.3, AC026750.2, AC026809.1, AC016517.4, AP001561.1, AP000641.1, AP000799.1, AC006909.1, AC009600.11, AC055839.2, AC013509.3, AL121980.6, AC008506.6, AC026610.2, AC021592.3, AC018406.2, AC021065.3, AL137072.1, Z93927.3, AC009822.3, AC068191.1, AC027003.2, AC016458.2, AC022269.3, AC018740.2, AC005308.6, ACOl 1267.2, AF188028.1, AC012670.2, AC016998.1, AL356112.2, AL136358.4, AL158839.2, AL109808.2,

SEQ ID NO.239

NGO-St-116

YS1731/T7 3'

M22382.1, NM_002156.1, M34664.1, AJ250915.1, AC006511.5, M22383.1, X53585.1, X54793.1, X53584.1, AC004220.1, AL096817.12, M34663.1, AF227510.1, AL163248.2, X55023.1, U68562.1, M34662.1, M34660.1,

M34661.1, M34562.1, AF025468.2, AF069298.1, AL161494.2, L36035.1, AF240627.1, AF197942.1, AL163218.2, AL109763.2, U58764.1, AC024848.1, ACOl 1594.8, AC004038.1, AE000808.1, Z81571.1, AL096701.14, X79205.1, AP000183.1, AP000038.1, AP000107.1, M74012.1, AC007320.2, AF214118.1, AC005200.1, U67521.1, AL034429.1, AL161505.2, AL133396.1, Z35719.1, Z82253.1, Z70272.1, APOOl 115.1, AB019234.1, AA630404.1, AA826248.1, AI832486.1, AI609776.1, AW246607.1, AA769669.1, AI818534.1, AA565131.1, AW573149.1, AI221866.1, AA448453.1, AI619432.1, AW177563.1, AI827012.1, AW004895.1, AI926703.1, AI924961.1, AW276236.1 , AI627740.1 , AW410099.1, AW102810.1, AI961421.1, AI956156.1, AW131404.1, AI570191.1, AI325539.1, AW157717.1, AI690942.1, AA564099.1, AI922978.1, AI189669.1, AW469262.1, AI217363.1, AI985757.1, AI885544.1, AI801296.1, AW780292.1, AW276334.1, AA629677.1, AA600146.1, AA595763.1, AW439804.1, AWl 17832.1, AI609928.1, AA603962.1, AA102391.1, AW156968.1, AW071129.1, AW246632.1, AI678654.1, AI582821.1, AW304695.1, AA948019.1, AA167738.1, AW513062.1 , AI683208.1 , AI571107.1 , AW675607.1 , AA609838.1 , AI285386.1 , AA515520.1 , AW068921.1, AI284071.1, AA617879.1, AI335167.1, AA847770.1, AA218869.1, AW572206.1, AI565115.1, AA577528.1, AA978125.1, AA181826.1, AW419186.1, AA583474.1, AI983518.1, AI023089.1, AW104022.1, AI521493.1, AA605126.1, AI075218.1, AA774671.1, AA479788.1, AA130632.1, AW516994.1, AW513837.1, AW084921.1, AI612727.1, AA970442.1, AI744383.1, AA196514.1, AI168478.1, AI573195.1, AA219578.1, AA164508.1, AW572335.1, AW085863.1, AW674312.1, AA970965.1, AW192162.1, AA133938.1, AC010746.3, AC024884.6, AC027473.2, AC032001.2, AL136079.3, AL138760.4, AL354869.1, AC026299.2, AF252831.1, AF252830.1, AF202031.1, AF189745.1, AC008821.4, AC008840.3, AC008511.4, AC063980.1, AL137180.3, AL160258.3, AF260011.1, AC026746.3, AC016645.3, AC026750.2, AC026809.1, AC016517.4, AP001561.1, AP000641.1, AP000799.1, AC006909.1, AC055839.2, AC008506.6, AC025073.2, AC026610.2, AC021592.3, AC018406.2, AC021065.3, AL137072.1, Z95311.10, Z93927.3, AC009822.3, AC068191.1, AC016458.2, AC018740.2, ACOl 1267.2, AF188028.1, AC012670.2, AL356112.2, AL158839.2, AL158012.2, AL109808.2,

SEQ ID NO.240 NGO-St-116 YS1784/T7 3'

AJ250915.1, M22382.1, NM_002156.1, M34664.1, AC006511.5, M22383.1, X54793.1, X53585.1, X53584.1, AC004220.1, AL096817.12, M34663.1, AF227510.1, AL163248.2, M34662.1, M34660.1, U68562.1, X55023.1, M34661.1, M34562.1, AF025468.2, AF069298.1, AL161494.2, L36035.1, AF197942.1, U58764.1, AC024848.1, ACOl 1594.8, AC004195.1, AC005960.1, AE000808.1, Z81571.1, X79205.1, AP000510.2, AP000183.1, AP000038.1, AB023060.1, AP000107.1, M74012.1, AC007320.2, AC004921.1, AC008122.15, AC000108.1, U67521.1, AL161505.2, ALl 33396.1, Z35719.1, ALl 18497.9, Z82253.1, Z70272.1, APOOl 115.1, AA630404.1, AA826248.1, AI609776.1, AW246607.1 , AI818534.1 , AI832486.1 , AW573149.1 , AA769669.1 , AA565131.1, AI221866.1 , AA448453.1 , AW410099.1, AW157717.1, AI325539.1, AI609928.1, AW131404.1, AW177563.1, AI217363.1, AW276236.1, AWl 17832.1, AI961421.1, AI926703.1, AI627740.1, AI189669.1, AW469262.1, AI985757.1 , AI690942.1, AA600146.1, AI924961.1 , AI619432.1 , AI570191.1 , AW513062.1 , AW246632.1 , AWl 02810.1 , AI582821.1, AA564099.1 , AW004895.1 , AI922978.1, AI827012.1, AA603962.1, AA629677.1, AA102391.1 , AW276334.1, AI956156.1, AW304695.1, AI678654.1, AI285386.1, AA948019.1, AW156968.1, AW780292.1 , AW439804.1 , AW071 129.1, AI885544.1, AA595763.1, AI683208.1, AI801296.1, AI571107.1 , AA515520.1, AW675607.1, AI284071.1 , AW068921.1 , AI335167.1 , AA167738.1, AA617879.1, AA609838.1, AW572206.1 , AA847770.1, AA218869.1, AW419186.1, AI565115.1, AA583474.1, AA978125.1, AA181826.1, AI023089.1, AA577528.1, AI983518.1 , AA605126.1 , AW104022.1, AA774671.1, AW513837.1, AA479788.1, AA130632.1, AW516994.1, AI521493.1 , AI075218.1, AI612727.1 , AA970442.1, AI573195.1, AI744383.1, AI168478.1 , AA219578.1, AA164508.1, AW572335.1, AA196514.1, AW192162.1, AW104912.1, AA970965.1, AW236411.1 , AA133938.1, AW674312.1, AC010746.3, AC024884.6,

AC027473.2, AC032001.2, AL136079.3, AL138760.4, AL354869.1, AC026299.2, AF252831.1 , AF252830.1 , AF202031.1, AF189745.1 , AC008821.4, AC008840.3, AC008511.4, AL137180.3, AL160258.3, AC063980.1, AF260011.1, AC026746.3, AC016645.3, AC026750.2, AC026809.1, AC016517.4, AP001561.1, AP000799.1, AP000641.1, AC006909.1, AC055839.2, AC008753.7, AC026610.2, AC018406.2, AC021065.3, AL137072.1, AC009822.3, AC068191.1, AC064839.3, AC022269.3, AC018740.2, AC005308.6, ACOl 1267.2, AC013285.5, AF188028.1, AC012670.2, AC006875.1, AL356112.2, AL136358.4, AL159970.7, AL158839.2, AL109808.2,

SEQ ID NO.241 NGO-St-116 YS1796/T7 3'

AJ250915.1, M22382.1, NM_002156.1, M34664.1, AC006511.5, M22383.1, X54793.1, X53585.1, X53584.1, AC004220.1 , AL096817.12, M34663.1 , AF227510.1 , ALl 63248.2, M34662.1 , M34660.1 , U68562.1 , M34661.1, X55023.1, AF025468.2, AF069298.1 , AL161494.2, L36035.1, X02895.1 , AFl 97942.1, U58764.1, AC024848.1, ACOl 1594.8, AC004038.1 , AEOOl 112.1, AE000808.1, Z81571.1, X79205.1, AP000183.1, AP000038.1, AP000107.1, M74012.1, AC007320.2, AC008122.15, AC003688.1, AC005200.1, U67521.1, AL034429.1, AL161505.2, AL133396.1 , Z35719.1, ALl 18497.9, Z82253.1, AL096776.12, Z70272.1, M91463.1, APOOl 115.1, M34562.1, AA630404.1 , AA826248.1, AW246607.1, AI609776.1, AW410099.1, AI221866.1, AA565131.1, AI818534.1, AI325539.1, AA769669.1, AI832486.1, AA603962.1, AA448453.1, AW573149.1, AW157717.1, AI189669.1, AW246632.1, AI582821.1, AI217363.1 , AA600146.1, AW177563.1, AA948019.1, AA629677.1 , AA515520.1 , AA564099.1, AW469262.1, AW276236.1, AW156968.1, AI961421.1, AI827012.1, AI627740.1, AA102391.1, AI609928.1, AA595763.1, AI285386.1 , AA617879.1 , AW780292.1, AW068921.1, AW439804.1, AI284071.1, AA609838.1, AW131404.1, AI619432.1, AI956156.1, AI926703.1, AA847770.1, AA167738.1, AW102810.1, AI985757.1, AI924961.1, AI571107.1, AW117832.1 , AI570191.1, AI335167.1, AA218869.1, AW004895.1, AA181826.1, AW071129.1, AI801296.1 , AA577528.1, AW304695.1, AI885544.1, AI683208.1, AW675607.1, AW276334.1, AI922978.1, AI678654.1, AA978125.1, AI690942.1, AA583474.1 , AI023089.1 , AW513062.1 , A W572206.1 , AA605126.1 , AI565115.1, AA774671.1 , AA479788.1 , AA130632.1, AI075218.1, AW516994.1, AW513837.1, AI983518.1, AW104022.1, AA970442.1, AW419186.1, AI744383.1, AI521493.1, AA196514.1, AI168478.1, AI573195.1, AA219578.1, AA164508.1, AI612727.1, AW2364U.1, AW192162.1, AW104912.1, AA970965.1, AW085863.1, AA133938.1, AW674312.1, AC010746.3, AC024884.6, AC027473.2, AL136079.3, AC032001.2, AL138760.4, AL354869.1, AF252831.1, AF252830.1, AF202031.1, AF189745.1, AC008821.4, AC008840.3, AC00851 1.4, AC026299.2, AL137180.3, AL160258.3, AC063980.1 , AF260011.1, AC026746.3, AC016645.3, AC026750.2, AC026809.1, AC016517.4, AP001561.1, AP000641.1, AC006909.1, AP000799.1, AC055839.2, AC026610.2, AC021592.3, AC018406.2, AC021065.3, AL354917.1 , ALl 37072.1, AC009822.3, AC068191.1, AC027003.2, AC016458.2, AC022269.3, AC024740.2, AC018740.2, AC005308.6, AC013771.3, ACOl 1267.2, AF188028.1, AC012670.2, AC016998.1, AC009232.2, AL356112.2, AL158839.2,

SEQ ID N0.242

NGO-St-116

YS353/T7 3'

M22382.1, NM_002156.1, M34664.1, AJ250915.1, AC006511.5, M22383.1, X53585.1, X54793.1, X53584.1 , AC004220.1, AL096817.12, M34663.1, AF227510.1, AL163248.2, U68562.1, X55023.1 , M34662.1, M34660.1, M34661.1, M34562.1, AF025468.2, AF069298.1 , AL161494.2, L36035.1, X02895.1, AF240627.1 , AFl 97942.1, AL109763.2, U58764.1, AC024848.1, ACOl 1594.8, AEOOl 112.1, AE000808.1, AL163260.2, Z81571.1 , AL096701.14, X79205.1, AP001715.1, AP000183.1, AP000038.1, AP000107.1, M74012.1 , AC007320.2, AC008122.15, AC000108.1, AC005200.1 , U67521.1, AL034429.1 , ALl 61505.2, ALl 33396.1 , Z35719.1 , ALl 18497.9, Z82253.1 , Z70272.1 , APOOl 115.1, AB019234.1, AA630404.1, AA826248.1, AI832486.1, AI609776.1, AA769669.1, AW246607.1, AI818534.1, AA565131.1, AI619432.1, AW004895.1, AI827012.1, AI926703.1, AI627740.1, AI956156.1, AW102810.1, AI221866.1, AW573149.1, AI924961.1 , AW276236.1, AW131404.1, AA448453.1, AW177563.1, AI961421.1, AI570191.1, AI922978.1 , AW469262.1, AW410099.1, AI690942.1, AA564099.1, AI985757.1, AI325539.1 , AH 89669.1, AW780292.1, AI885544.1, AI683208.1, AI678654.1, AA102391.1 , AW276334.1, AI801296.1, AW157717.1, AW304695.1 , AI217363.1 , AW439804.1, AW071129.1, AA629677.1 , AA600146.1, AA595763.1, AWl 17832.1, AA603962.1, AW156968.1, AW246632.1, AI582821.1, AI609928.1, AA948019.1, AW513062.1, AA167738.1, AI571107.1, AW675607.1, AA609838.1, AA515520.1, AI565115.1 , AI285386.1, AA617879.1, AW068921.1, AI284071.1, AI521493.1, AA847770.1, AI335167.1 , AA577528.1 , AA218869.1 , AA 181826.1 , AW572206.1 , AA978125.1 , AA583474.1 , AI023089.1 , AW419186.1, AI075218.1, AI983518.1 , AA605126.1, AI612727.1, AW104022.1, AW084921.1, AA774671.1 , AA479788.1, AA130632.1, AW516994.1, AW513837.1, AI744383.1, AA970442.1, AA196514.1, AI168478.1, AW085863.1, AI573195.1₎ AA219578.1, AA164508.1, AW236411.1, AW192162.1, AW572335.1, AA133938.1, AW674312.1, AC010746.3, AC024884.6, AC027473.2, AC032001.2, AL136079.3, AL138760.4, AC026299.2, AL354869.1, AF252831.1, AF252830.1, AF202031.1, AFl 89745.1, AC063980.1, AC008821.4, AC008840.3, AC008511.4, AL137180.3, AL160258.3, AF260011.1, AC026746.3, AC016645.3, AC026750.2, AC026809.1, AC016517.4, AP001561.1, AP000641.1, AP000799.1, AC006909.1, AC055839.2, AC026610.2, AC021592.3, AC018406.2, AC021065.3, AL137072.1, AC009822.3, AC026803.2, AC068191.1, AC027003.2, AC016458.2, AC018740.2, AC005308.6, ACOl 1578.3, ACOl 1267.2, AC012670.2, AC016998.1, AC009232.2, AL356112.2, AL109808.2, SEQ ID NO.243

NGO-St-117 combined;

NM_006117.1, AF153612.1, AF244138.1, AF069301.1, AF257175.1, D17030.1, NM_011868.1, AF153613.1, D17201.1, S80107.1, M15888.1, AL163270.2, AP001725.1, AP000689.1, AB003151.1, U11419.1, NM_012574.1, NM_008171.1, NM_000834.2, AC005232.1, ACOl 1915.3, U88963.1, AFl 11103.1, U11287.1, U90278.1. M91562.1, D10651.1, AC007000.2, NM_000508.1, AC004843.1, AC006014.2, AC004955.2, AC005488.2, AC007786.1, AC002082.1,

AC006504.1. M58569.1, LI 1356.1, AC005355.1, AC005273.1, U72724.1. U09205.1, AL158111.2, X62844.1. J00128.1, J00127.1, AB022216.1, M64982.1 , AC007042.2, AC016830.5, ACOl 1525.4, AC008101.15, AC002377.1, AC004953.1, AC007773.1, AF016667.2, AC005796.1, AJ009632.2, M96930.1, M13968.1, M77812.1, X79424.1, AI870279.1, AI807002.1, AL036852.1, AI564314.1, AI565595.1, W67775.1, AW270727.1, AI610377.1, AW662848.1, AL046860.2, AA617696.1, AA934587.1, AI096931.1, AA628682.1, AW731836.1, AA913577.1, AI391743.1, AW474447.1,

AI363079.1 , AI336097.1 , AI432577.1 , AI352108.1 , AI352327.1 , AA969876.1 , AA995606.1 , W74527.1 , AA622402.1 , AI085901.1, AA027090.1, AI307399.1, W28824.1, AI971940.1, AI287814.1, AA620556.1, W79046.1, AA188052.1, AW194674.1, AW182085.1, AA085733.1, AA187157.1, AI625204.1, AI031865.1, AA426250.1, AW591699.1, AA897169.1, AA393863.1, AA972318.1, AI349588.1, AI674578.1, AI659404.1, AW750808.1, AW302400.1, AA027130.1 , AAl 1 569.1 , F36532.1 , AI371256.1 , AW023925.1 , AA365494.1 , AA733183.1 , AA531124.1 , F30300.1 , AA282967.1, AI370734.1, T71475.1, T90909.1, Z25096.1, AI432578.1, AA380387.1, AAl 57205.1, AW088726.1, AA721771.1, AAl 15089.1, T83325.1, T49643.1, R00622.1, T83700.1, N93780.1, F00243.1, AI872750.1, R00626.1, R00525.1, AI471045.1, R08138.1, R00521.1, AW369701.1, AA380460.1, N74066.1, AI909238.1, AI370415.1, W67774.1, AA658299.1, T55344.1, AW744236.1, AW742885.1, AU079751.1, AI930460.1, AI528379.1, AW210430.1, AAl 18832.1, AA153061.1, AL033383.25, AL136309.3, AL355594.3, AC021873.7, AC068763.2, AC022912.3, AC034235.2, AC021642.11, AC024709.4, AC025502.2, AC024325.2, ACOl 1986.3, AL137142.8, AL133407.4, AL139254.3, AL354955.1, AL354859.1, APOOl 804.1, AC020947.5, AC007003.2, AC004867.2, AC027394.2, AC007343.3, AC012350.3, AC023284.1, AC016456.2, AC013532.2, AC005143.1, AC004581.1, AL353618.2, AP000796.1, SEQ ID N0.244 NGO-St-117 YS025/T3 5'

AF257175.1, AF069301.1, AF244138.1, NM_006117.1, AF153612.1, D17030.1, NM_011868.1, AF153613.1, S80107.1, M15888.1, AE003426.1, NM_000508.1, M58569.1, LI 1356.1, U09205.1, M16153.1, AL132964.2, AL035436.3, J00128.1, J00127.1, X17570.1, M64982.1, AC022078.12, AC020647.9, AC006392.1, AFOO 1548.1, AC005034.1, ACOl 1331.1, AF123727.1, AF058692.1, AF058691.1, AL034426.4, X97253.1, AB020673.1, M77812.1, L23921.1, D10667.1, AL046860.2, AA188052.1, W28824.1, AI971940.1, AA380387.1, F00243.1, AA157205.1, AW023925.1, AA531124.1, AU079751.1, AI930460.1, AI528379.1, AA353778.1, AW476551.1, AW210430.1, AA380460.1, AA244463.1, AA137720.1, AA118832.1, W97106.1, AA674322.1, AI020701.1, AA645183.1, AI892596.1, AI019310.1, AA717623.1, W48327.1, AI155958.1, AI025290.1, AA153061.1, AW463230.1, AW462175.1, AW359742.1, AW323611.1, AI653280.1, AI217226.1, AI208802.1, AI028745.1, AI018748.1, AA815401.1, AA412669.1, AA399269.1, AW750808.1, AW742226.1, AA103723.1, AA030780.1, AW743307.1, AW229796.1, AA066905.1, AW012459.1, AA575384.1, AW478977.1, R00525.1, AA467514.1, W89322.1, N55668.1, R00521.1, AI909238.1, AA690248.1, AI303965.1, AA717411.1, AA426250.1, AA393863.1, AI891995.1, AI891994.1, AI891993.1, AI789433.1, AA277873.1, AA675395.1, AA980640.1, AI154739.1, W78509.1, AA813227.1, AI154475.1, AA210546.1, AA145999.1, AV123543.1, AI509051.1, AI203473.1, AW320942.1, AA282967.1, W67774.1, AW805054.1, AI207457.1, All 33428.1, All 14445.1, AA800548.1, AA436648.1, AA382695.1, AA344542.1, AA026737.1, N33594.1, H67459.1, T95711.1, T74407.1, T73868.1, T72304.1, T71715.1, T61743.1, T60362.1, AL355594.3, AL033383.25, AL136309.3, AL354935.3, AL161792.4, AC024709.4, AL354859.1, AL160291.2, AC025257.5, AC032040.2, AC012350.3, AC009583.3, AC024470.2, AC023284.1, AC010883.3, AC013106.1, AL353618.2, AP000796.1, AC008250.16, AC024904.5, AC046176.2, AC026761.2, AC068593.1, AC008761.3, AC066731.1, AC026932.2, AC047816.1, AC049963.1, AC039392.1, AC009616.3, AC026082.3, AC016089.4, AC018827.4, AC025553.2, ACOl 1660.4, AC018607.3, AC023879.2, AC023571.2, AC019037.2, AC012655.4, AC022661.2, AC010683.3, AC012579.2, AC019027.2, AF128834.1, AL355353.3, AL162291.8, AL355680.2, AL136322.2, AL136158.12, AL138801.5, AL136526.15, AL353808.1, AL122035.2, AP001991.1, AP001851.1,

SEQ ID N0.245 NGO-St-117 YS025 T73' NM_006117.1, AF153612.1, AF069301.1, AF257175.1 , AF244138.1 , NM_011868.1, AFl 53613.1, ALl 63270.2, AP001725.1 , AP000689.1, AB003151.1, U11419.1, NM_012574.1, NM_008171.1, NM_000834.2, AC005232.1, ACOl 1915.3, U88963.1 , AFl 11 103.1, AC005304.1 , Ul 1287.1, U90278.1, M91562.1, D10651.1, AE003498.1, AC007000.2, AC004843.1, AC006014.2, AC005488.2, AC004878.2, AC007786.1, AC002082.1 , AC005071.2, AC006504.1, AC005355.1, AC005273.1, U72724.1, AL121767.3, AL133233.2, AB022216.1, ACOl 1525.4, AC004953.1, AC006487.7, AL352976.2, AJ239322.3, APOOl 135.2, AI870279.1 , AI807002.1 , AL036852.1, AI564314.1, AI565595.1, W67775.1 , AW270727.1, AI610377.1, AW662848.1, AA617696.1, AA934587.1, AI096931.1 , AA628682.1 , AW731836.1 , AA913577.1, AI391743.1, AW474447.1, AI363079.1, AI336097.1, AI432577.1, AI352108.1, AI352327.1, AA969876.1, AA995606.1, W74527.1, AA622402.1, AI085901.1, AA027090.1 , AI307399.1, AI287814.1, AA620556.1, W79046.1 , AW194674.1, AW182085.1, AA085733.1, AA187157.1, AI625204.1, AI031865.1, AW591699.1, AA897169.1 ,

AA972318.1, AI349588.1, AI674578.1, AI659404.1, AA365494.1, AW302400.1, F36532.1, AI371256.1, AA733183.1, AA531 124.1, F30300.1, AA027130.1, AAl 15569.1, AI370734.1 , T90909.1 , Z25096.1 , T71475.1, AI432578.1, AA426250.1 , AW088726.1, T83700.1, AA721771.1, AA393863.1, AAl 15089.1, T49643.1, R00622.1, AA282967.1, T83325.1, N93780.1 , AW750808.1, AI872750.1, R00626.1, R08138.1, AI471045.1 , AW369701.1, N74066.1, AI370415.1, AA003997.1, AW744236.1, AA250467.1, AA658299.1, AA968175.1 , AA848318.1, AW742885.1, T55344.1, AW557746.1, AI877303.1, AW208617.1, AA260498.1, AW322345.1, AI500088.1, AA958697.1, AA397074.1 , AA008542.1, AA036229.1, AA253686.1, AW456866.1, AI931743.1, AI411403.1, AW743789.1, AL033383.25, AL136309.3, AL355594.3, AC021873.7, AC068763.2, AC022912.3, AC034235.2, AC021642.1 1, AC025224.3, AC025502.2, AC024325.2, AC019078.3, AC016030.2, AL137142.8, AL133407.4, AL139254.3, AL354955.1, AP000916.2, APOOl 804.1 , AC055832.2, AC004166.10, AC020947.5, AC010246.4, AC010348.3, AC061712.2, AC009061.8, AC005073.2, AC007003.2, AC010139.3, AC027394.2, AC012350.3, AC010947.3, AC025740.1 , AC013532.2, AC024932.3, AC025817.2, AC019142.4, AC034105.1, AC010760.2, AC016441.4, AL356139.2, AL137024.6. AL133403.6, SEQ ID NO.246 NGO-St-117 YS062 T3 5'

NM_006117.1 , AF153612.1, AF244138.1, AF257175.1 , AF069301.1, D17030.1, NM_011868.1, AF153613.1, D17201.1, S80107.1, M15888.1, NM_000508.1, M58569.1, LI 1356.1, U09205.1, J00128.1, J00127.1, M64982.1, AE003488.1 , AC020647.9, AF001548.1, AC005034.1, ACOl 1331.1, AF123727.1, AE001039.1, AL034426.4, X97253.1, AB020673.1, M77812.1, D10667.1, AL046860.2, W28824.1, AI971940.1, AA188052.1, AW023925.1, AA380387.1, AA157205.1 , F00243.1, AW750808.1, AA426250.1, AA393863.1 , AA380460.1, R00525.1, R00521.1 , AI909238.1, AU079751.1, AI930460.1, AI528379.1, N55668.1, AW476551.1, AW210430.1, AA244463.1, AA137720.1, AAl 18832.1, W97106.1, AA674322.1, AI020701.1, AA645183.1, AI892596.1 , AA531124.1 , AI019310.1, AA717623.1, W48327.1, AI155958.1, AI025290.1, AA153061.1, AA282967.1 , W67774.1, AA353778.1, AW463230.1, AW462175.1 , AW359742.1 ,

AW32361 1.1, AI653280.1, AI217226.1, AI208802.1, AI028745.1 , AIO 18748.1, AA815401.1, AA412669.1, AA399269.1 , AW742226.1, AA103723.1, AA030780.1, AW743307.1 , AW229796.1 , AA066905.1, AW012459.1, AA575384.1, AW478977.1, AA467514.1, AAl 15569.1, W89322.1, AA027130.1, AA690248.1 , AI891994.1, AI891993.1, AI789433.1, AI303965.1, AA717411.1, AA277873.1, AI509051.1, AI891995.1, AI154739.1, AA675395.1, AI564314.1, AA980640.1, AI608378.1, W78509.1, AA289292.1, AA813227.1, AI121770.1, W91218.1, AW744236.1, AI154475.1, AA210546.1, AA145999.1 , T83700.1, R08138.1, AV123543.1, AI203473.1, AW320942.1, AA800548.1, AA382695.1, AA344542.1, AA026737.1, H67459.1, T74407.1, T73868.1, T60362.1, AL355594.3, AL033383.25, AL136309.3, AC024709.4, AL354859.1, AL160291.2, AC025257.5, AC032040.2, AC012350.3, AC009583.3, AC024470.2, AC023284.1, AC010883.3, AC008300.1, AL353618.2, AP000796.1, AC008250.16, AC024904.5, AC026761.2, ACOl 1351.3, AC011368.3, AC068593.1, AC026932.2, AC009616.3, AC026082.3, AC016089.4, AC018827.4, AC012111.3, AC025553.2, ACOl 1660.4, AC023879.2, AC023571.2, AC019037.2, AC012655.4, AC020885.2, AC022661.2, AC010683.3, AC019027.2, AC012729.1, AL157833.5, AL355353.3, AL162291.8, AL355680.2, AL136322.2, AL136158.12, AL138801.5, AL136526.15, AL353808.1, AL122035.2, AP001991.1, AP001851.1 , SEQ ID NO.247 NGO-St-1 17 YS062/T7 3'

NM_006117.1, AF153612.1, AF069301.1, AF244138.1, AF257175.1 , NM_011868.1, AF153613.1, AL163270.2, AP001725.1, AP000689.1, AB003151.1 , U11419.1, NM_012574.1, NM_008171.1, NM_000834.2, AC005232.1, AC011915.3, AC007535.3, U88963.1, AFl 11 103.1, AC005304.1, Ul 1287.1, U90278.1, M91562.1 , D10651.1, AE003498.1, AC007000.2, AC004843.1, AC006014.2, AC004955.2, AC005488.2, AC004878.2, AC007786.1 , AC002082.1, AC005071.2, AC006504.1, AC005355.1 , U72724.1, AE000665.1, AL121767.3, AL133233.2, AB022216.1, AF260700.1, ACOl 1525.4, AF182322.1, AC004953.1, AC006487.7, AC005796.1, AL352976.2, AL353820.1, AJ239322.3, AJ239318.3, Z75955.1, AJ009632.2, AP001342.1, AP001135.2, M16512.1, M80474.1, M13968.1, X79424.1 , AI870279.1 , AI807002.1, AL036852.1, AI565595.1 , AI564314.1, W67775.1, AW270727.1, AI610377.1, AW662848.1, AA617696.1,

AA934587.1 , AI096931.1, AA628682.1, AW731836.1, AA913577.1, AI391743.1, AW474447.1 , AI363079.1, AI336097.1, AI432577.1, AI352108.1, AI352327.1, AA969876.1 , AA995606.1 , W74527.1, AA622402.1, AI085901.1, AA027090.1, AI307399.1, AI287814.1, AA620556.1, AW194674.1, W79046.1, AW182085.1, AA085733.1 , AA187157.1, AI625204.1, AI031865.1, AW591699.1, AA897169.1, AA972318.1 , AI349588.1, AI674578.1, AI659404.1, AW302400.1, F36532.1, AI371256.1, AA733183.1, AA531124.1, AA365494.1, F30300.1, AI370734.1, T90909.1, Z25096.1, AA027130.1, AA 115569.1 , T71475.1 , AI432578.1 , AW088726.1 , AA721771.1 , AA 115089.1 , T49643.1 , R00622.1 , T83325.1 , AA426250.1 , N93780.1, T83700.1, AA393863.1, AA282967.1, AI872750.1, R00626.1, AI471045.1 , AW750808.1, AW369701.1, R08138.1, N74066.1, AI370415.1 , AA658299.1, T55344.1, AA003997.1, AW744236.1, AW742885.1, AA250467.1 , AW557746.1, AW208617.1, AA968175.1, AW322345.1, AI500088.1, AA260498.1, AA848318.1, AA958697.1, AI877303.1, AA397074.1, AA008542.1, AA036229.1, AW456866.1, AI931743.1, AA253686.1 , AW743789.1 , AI41 1403.1, AL033383.25, AL136309.3, AL355594.3, AC021873.7, AC068763.2, AC022912.3, AC034235.2, AC025224.3, AC025502.2, AC024325.2, AC019078.3, AL137142.8, AL133407.4, AL139254.3, AL354955.1, AP000916.2, APOOl 804.1 , AC055832.2, AC004166.10, AC020947.5, AC010246.4, AC010348.3, AC009061.8, AC067929.1 , AC025127.2, AC005073.2, AC007003.2, AC004867.2, AC027394.2, AC012350.3, AC010947.3, AC025740.1, AC018553.2, AC013532.2, AL355552.1, AL139294.1,

SEQ ID NO.248 NGO-St-117 YS286/T7 3'

NM_006117.1 , AF153612.1 , AF069301.1, AF257175.1, AF244138.1, NM_01 1868.1, AF153613.1, AP000689.1, AB003151.1, Ul 1419.1, NM_012574.1, NM_008171.1 , NM_000834.2, AC005232.1, AC011915.3, U88963.1 , AFl 11103.1, AC005304.1, Ul 1287.1, U90278.1, M91562.1, D10651.1, AE003498.1, AC007000.2, AC004843.1, AC006014.2, AC005488.2, AC004878.2, AC007786.1, AC002082.1, AC00507I .2, AC006504.1 , AC005355.1, AC005273.1, U72724.1, U17243.1, AL121767.3, AL133233.2, AB022216.1, ACOl 1525.4, AF024504.2, AC004953.1, AC007773.1, AC006487.7, AC005796.1, AL352976.2, AJ239322.3, Z75955.1, APOO 1342.1 , APOOl 135.2, AI870279.1 , AI807002.1, AL036852.1, AI564314.1, AI565595.1, W67775.1, AW270727.1, AI610377.1, AW662848.1, AA617696.1, AA934587.1, AI096931.1, AA628682.1 , A W731836.1 , AA913577.1, AI391743.1, AW474447.1 , AI363079.1 , AI336097.1, AI432577.1, AI352108.1, AI352327.1, AA969876.1, AA995606.1, W74527.1, AA622402.1, AI085901.1, AA027090.1, AI307399.1, AI287814.1 , AA620556.1, W79046.1, AW194674.1, AWl 82085.1, AA085733.1, AA187157.1, AI625204.1, AI031865.1 , AW591699.1 , AA897169.1 , AA972318.1 , AI349588.1 , AI674578.1 , AI659404.1 , AA365494.1 , AW302400.1 , F36532.1, AI371256.1 , AA733183.1, AA531124.1, AA027130.1, AAl 15569.1, F30300.1, AI370734.1, T90909.1 , Z25096.1, T71475.1, AI432578.1, AA426250.1, AW088726.1 , T83700.1, AA393863.1, AA721771.1, AAl 15089.1, T49643.1, AA282967.1, R00622.1 , T83325.1, N93780.1, AW750808.1 , AI872750.1 , R00626.1, R08138.1, AI471045.1, AW369701.1 , N74066.1, AI370415.1, AA658299.1, AA003997.1, AW744236.1, AA250467.1, T55344.1 , AA848318.1 , AA968175.1, AW742885.1, AW322345.1, AW208617.1, AW557746.1, AI877303.1, AI500088.1, AA260498.1 , AA958697.1, AA397074.1, AA008542.1 , AA036229.1, AW456866.1, AI931743.1, AA253686.1, AI411403.1, W67774.1, AL033383.25, AL136309.3, AL355594.3, AC021873.7, AC068763.2, AC022912.3, AC034235.2, AC025224.3, AC025502.2, AC024325.2, AC019078.3, AL133293.18, AL137142.8, AL133407.4, AL139254.3, AL354955.1, AP000916.2, AP001804.1, AC055832.2, AC004166.10, AC020947.5, AC010246.4, AC010348.3, AC061712.2, AC009061.8, AC005073.2, AC007003.2, AC010139.3, AC004867.2, AC027394.2, AC012350.3, ACOl 1039.4, AC010947.3, AC025740.1, AC013532.2, AC005143.1, AL355487.1,

SEQ ID NO.249 NGO-St-118 YS1802/T7 3'

NM_001655.1, X81 198.1, AFl 11 103.1, AFl 11102.1, S74341.1, AF151870.1, NM_016049.1 , AE003475.1, AL136295.2, U32692.1, AF019376.1, Z70680.1, AE003528.1, AC004931.1, AE000604.1, AC006050.1, ALl 17667.2, AL096862.18, Z46793.1, AL035250.17, AL031224.1, Z99289.1, AL109798.19, ALl 12548.1, L29789.1, AA412680.1, AI755123.1, AA 102578.1 , AA206349.1 , AW055098.1 , AA293170.1 , AW439825.1 , AW269634.1 , AI076926.1 , AI025067.1 ,

AI700509.1, AI078164.1 , AI697821.1, AA705915.1, AI160192.1, AI093354.1, AA165600.1, AA705055.1, AA527537.1, AA192464.1, AI653666.1, AI264667.1, AI650293.1, AI091869.1, AA506760.1, AI950897.1, AI380068.1, AI264617.1, AI125887.1, AA047461.1, AI890839.1, AI683902.1 , N24749.1, N32156.1, AI302074.1, AA088764.1, N26132.1 , AI040426.1, AI358017.1, AI141871.1, AW474078.1, AI523696.1, N32947.1, AA688242.1, AI961853.1, AI446329.1 , AI002397.1, AA993720.1, AA707731.1, AA422132.1, H99310.1, AI879755.1, AI918396.1, AA804436.1, AA928305.1, AW168784.1, AA719418.1, AI087106.1, AI024105.1, AW129693.1, W15326.1, H94333.1, AI962023.1, W42458.1, N21273.1 , AW194030.1 , AA856562.1, AI758429.1, AA243440.1, AA434593.1, W85810.1, AI079791.1, H99597.1, N67805.1, AA808672.1, AW303758.1, AI769314.1, R76982.1, AI754941.1 , N42618.1 , H98545.1, AA599213.1, AI832336.1, AA81 1624.1, H88780.1, AI886101.1, AI474209.1, H88997.1, N94593.1, AI888666.1, AA055972.1 , AA788790.1, AA491237.1, AI401139.1 , H96031.1, T99642.1, AA598401.1, AA026110.1, Z40496.1, AI658990.1 , AP000941.2, AP000846.1, AP000869.1, AC019068.3, AC019509.1, AC010015.3, AC036149.2, AC027187.2, AC025241.2, AC026015.2, AC027724.1, AC012532.3, AC015914.3, AC022658.3, AC024732.2, AC016276.2, AC002317.1, AL163952.1, AL135929.4, AC000380.1, AL135909.3, AC020636.4, AC023892.11, AC010856.3, AC055864.2, AC023156.3, AC068590.1 , AC025079.3, AC021269.3, AC013670.3, AC021378.3, AC060765.1, AC058803.1, AC021 150.5, AC013386.4, AC019162.3, AC027521.1, AC018425.3, AC012274.2, AC024231.3, AC025978.1, AC013331.4, AC016418.4, AC023018.2, AC021567.2, ACOl 1783.3, AC012436.4, AC020636.3, AC010066.5, ACOl 1892.3, AC014423.1, AL121919.13, AL353638.2, AL160285.5, AL139284.3, AL356033.1, AL354000.2, AL354985.2, AL161451.4, AL157950.3, AL353774.1, AL160290.3, AL139003.1, AP001393.1, SEQ ID NO.250 NGO-St-119 YS334/T3 5'

NM_003146.1, M86737.1 , S50213.1 , L08814.1, L08815.1, U84139.1, AB004793.1, AE003462.1, X68408.1, L08825.1, AL031904.1 , AL035653.12, AC007058.2, U40759.1, NC_001145.1, AE002662.1, AE002914.1, AE003202.1, AE00271 1.1, AC007285.3, AL163298.2, AL163002.1, S74619.1, Z48622.1, AP001753.1, AB001517.1, AP001055.1, Z79396.1, AW247262.1, AA258912.1, AA443507.1, AA085435.1, AA312302.1, F07281.1, AA359039.1, D55248.1 , D54571.1, D54563.1, D54952.1, D54973.1, AW802206.1, D53930.1, AA355756.1, AA404188.1, AI556014.1 , AA104553.1 , AL138347.1, AW489221.1, AA253486.1, AW320565.1, AA088369.1, H10266.1, AW401443.1, D77299.1 , AW381661.1, AA993395.1 , AA464881.1, AA036329.1, AI913779.1, AA476079.1, AA306252.1, AA590151.1, AW748405.1 , AW366265.1, AA130307.1, AI789443.1, AW378315.1, AW269617.1, AW370347.1 , AW480897.1, AA497585.1 , AW536819.1, AW536546.1, AU060291.1, AA162184.1, W07230.1, AP000781.2, AC020482.1, AC009182.3, AL139094.5, AC044849.2, AC020624.5, AC016588.5, AC010741.3, AL161790.3, AC068888.2, AC013552.4, AC022413.3, ACOl 1472.5, AC068473.1, AC024176.4, AC019023.3, AC019286.4, AC024462.2, AC020561.2, AC016441.4, AC022770.4, AC025303.1, AC006286.13, AC021638.5, AC018018.1, AC018205.1, AC003656.1, AL356318.1, AL355178.2, AL133463.8, AL160401.4, AL139816.4, AL158160.1, ALl 18500.5,

SEQ ID N0.251 NGO-St-119 YS334/T7 3'

NM_003146.1, M86737.1, S50213.1, U84139.1, L08814.1 , AC007967.3, AC0171 11.4, AC026237.4, AC005313.2, AF130357.1, AC004918.1, AF131217.2, AF165124.1, AL163247.2, AL021938.1, AL035534.1, AB037738.1, AI200891.1, AI832834.1 , AI694393.1 , AI597819.1 , AA773470.1 , AA640958.1 , AI989881.1, AI954549.1 , AA669346.1 , AL043692.1 , AA872063.1, AW771391.1, AI653466.1 , AA488456.1, AI770053.1, AI719199.1 , AA181676.1, AI768076.1, AW250844.1, AI769368.1 , AI326218.1 , AI292284.1 , AA102606.1 , AW583325.1 , AA630377.1 , AW246563.1 , AI803290.1 ,

AW469194.1 , AW072040.1, AI801767.1, AA129398.1, AA129437.1, N47701.1, AW055203.1 , AA204842.1, AA403256.1, AW162590.1, AW873160.1, N47715.1, AA428207.1, AI802539.1 , AW474265.1, AW517489.1, AA155636.1, AA187844.1 , AI708178.1, AI298177.1, AA084865.1 , AW196881.1, AI802262.1, AA223606.1, AA188417.1, AW182589.1, AW601976.1, AI125376.1, AA983384.1, AI669267.1, AA047175.1, AI369594.1, AA640599.1, AA629829.1 , AA506517.1, AA426576.1, AI034453.1 , AI927125.1, AI198409.1, AA088196.1, AA644298.1, AAI 72185.1, AI024913.1, AA282185.1, AW772651.1, AA418911.1, AA679982.1, AA232539.1 , AA928645.1, AI421368.1, AW516350.1, AI249088.1, AA770296.1, AL042406.1, AI913779.1, AA102637.1, W92454.1, AW732257.1, AW194956.1, AI433062.1, AA203343.1, AA581113.1 , T29388.1, AA2588I 7.1, AA173277.1, AW873703.1, AI569301.1, AA522909.1 , H10212.1, AW138326.1, AI630694.1, AI475149.1, AA367901.1, AP000781.2, AC068719.1, AL355364.3, AC021659.7, AC008383.4, AC010757.2, AC009475.3, AC012291.3, AC027118.2, AC023547.2, AC026245.1 , ACOl 1808.3, AC007856.6, AC015665.2, AL136227.4, AL356094.1,

SEQ ID NO.252 NGO-St-120 YS357/T3 5'

NM_013285.1, L05425.1, U69600.1, AL034379.8, AL021571.1, AB015478.1, X99436.1 , AC024751.1, AC006920.10, NM_009722.1 , NM_001681.1, AC006581.16, AJ223584.1 , AJ131821.1, AL121578.1, AL008715.1, X52496.1, X02814.1, M231 15.1, M23114.1, Zl 1500.1, J04703.1 , AF235167.1, AE00351 1.1, AC002045.1 , AC007216.2, U95742.1, AC002299.1 , AFl 96970.1, AC007283.3, AF013149.1, AF152363.1, AC005844.7, AC005841.3, AF001549.1, AC000385.1, AL049988.1, AL109865.36, Z50028.1, Z68325.1, Z82204.1, AL049849. I, S75106.1 , AK000019.1, AB020863.1, X07653.1, AA373618.1, AW245855.1, AW161434.1 , AW409934.1, AW163245.1, AA126101.1, AA690847.1 , AW362598.1, AW377646.1, AA858436.1, AL024316.1, AW377648.1, AW427911.1, H35824.1, AH 12354.1, AI573674.1 , AA684606.1, AI035443.1, AA316055.1, AA171883.1 , AV125438.1, AI853194.1, AA308223.1 , AW326870.1, AV125326.1, AA692026.1, AV138378.1, AA303227.1 , AA581348.1, AW765532.1, AA989948.1 , C70491.1, AW773907.1, D23001.1, AV442312.1, AW650351.1, AI994797.1, AI488290.1, N38238.1, T80141.1,

AW736578.1, AI077091.1, AI908898.1, AI847850.1, AI776439.1, AI467314.1, AI382397.1, AI290588.1 , AI091365.1, AA414121.1, AA409715.1, AA038677.1, AW738493.1, AI70921 1.1 , AI661426.1, AI482631.1, AH 14591.1, D78236.1, AA742179.1 , AA744826.1, AA663314.1, AA594218.1, AA452237.1, AA410224.1, AA298534.1, AA199847.1, H74324.1, R99587.1, AC023077.3, AC027731.2, AL355880.2, ACOl 1 124.3, AC018953.5, AC023502.3, AC026155.3, AC024905.7, AC06761 1.1, AC064107.1, AC056245.1, AC033416.1, AC027813.1, AC021828.2, AL138975.1, AC026677.2, AC022164.4, AC022147.4, AC023398.2, AC027006.2, AC025043.3, AC017041.2, AC016838.3, AC023448.2, AC021481.3, AC019325.3, AC023958.2, AC025279.1 , AC022408.3, AC016492.1, AP001767.1, APOOl 120.1,

SEQ ID O.253 NGO-St-120 YS357/T7 3'

NM H3285.1 , L05425.1, AL034379.8, U69600.1, AC007020.4, AF085279.1, L39991.1, AF176688.1, AC006200.2, AE003829.1, NM_010393.1, NM_006574.1, NM_002824.1 , AFl 26482.1, AF125444.1, AF059274.1, AF088905.1, AC005515.1 , AF016684.1, AL121748.6, Z72514.1, U20374.1, U47326. ] , X16423.1 , X16203.1, X16197.1, U07055.1, X64053.1, X16481.1, X65748.1, X00246.1 , Y13586.1, Y10211.1, M24398.1, M27134.1, M23445.1, L29190.1 , M27034.1, J00393.1, M63790.1, AC000365.1, NM_010398.1, AC007281.3, AF041855.1, AF057279.1, AF082510.1 , U88154.1 , U88153.1, U96752.1 , U91424.1, Z68106.1, AL020997.1, ALl 10509.2, X16198.1. X16424.1, AB021 155.1, Ml 1284.1, L00606.1, AW157242.1, AA902387.1, AI925558.1, AI628921.1 , AW070650.1, AA401208.1, AW409935.1, AW162279.1, AA722289.1, AW172793.1, AA126418.1, AA780182.1, AA857353.1, AW804193.1 , AW156969.1 , AW183614.1,

AI376281.1, AI826742.1, AA582490.1, AA446557.1 , AW246802.1, AI474094.1, AA483614.1, AA934590.1, AA846248.1, AI253092.1, AA888018.1, AW804232.1 , AI699045.1, AI954511.1, AA171554.1, AI867001.1 , AI760439.1, AW804255.1, AI763044.1 , AW804270.1, AI825244.1, AI671605.1, AA126000.1, AI702310.1, AA766044.1, AI798554.1, AW250835.1, W81287.1 , AW768894.1 , AA635139.1 , AW002316.1 , AW362969.1 , AWl 18384.1 , AA493881.1 , AI470650.1 , AA659293.1, AA863491.1, AA196109.1 , AA831455.1, AI244063.1, AA659297.1, N32569.1, AI245761.1, AA515590.1 , AI909114.1, T27737.1, AA524198.1, AW607751.1, AI345764.1 , AW301566.1, AI310849.1, AI310651.1, AW268086.1, AI589981.1, AA056760.1, AW268169.1, AA403201.1, AL135350.1 , AA614309.1, AI907635.1, AW529039.1, AH 12872.1, AI060050.1, AA546717.1, AW532741.1, AW557260.1, AV220510.1, AI646349.1, AI536459.1 , AW653179.1, AI853259.1, AV090573.1, AI058723.1, AV310274.1, AV236721.1 , AV236719.1, AV167761.1, AWl 11676.1 , AV311465.1, AV296078.1, AV225966.1, AA646750.1, AA472792.1, AAl 11295.1, AC027731.2, AL355880.2, AC023077.3, AC026348.3, AC068683.1, AC022553.2, AC023000.2, AC010058.5, AC013019.1 , AC010195.7, AC026992.2, AC027820.2, AC021884.2, AC022388.2, AC022937.3, AC019056.4, AC017422.1, AC015232.1, AC007438.6, AC006086.7, AC006087.12, AC002490.1 , AL159141.1, AC044907.2, AC022558.3, AC044814.2, AC025036.6, AC051623.1 , AC012145.3, AC021523.3, AC021296.2, AC007477.5, AC021959.4, AC006279.6, AC015535.4, AC020585.5, AC0251 10.1, AC010009.4, AC016767.3, AC019749.1, AC018050.1, AC016210.1, AC015148.1, AC009454.1, AL136090.10, AL135840.7, AL133341.9, AP001390.1, APOOl 120.1 ,

SEQ ID NO.254 NGO-St-121 YS363/T3 5'

AF098638.1, NM_004703.1, X77723.1, X91141.1, U70777.1, D85844.1, D86066.1, AB001750.1, D88828.1, D38038.1, Y08613.1, AF164343.1, AC000021.1, AB022176.1 , AL031003.1 , ACOl 1309.4, AC002089.1, AC013454.4, AC003019.1, U58108.1, L78833.1, AF051934.1, AL163268.2, AC0001 19.1, AL022476.2, S861 17.1, AJ229042.1, AB018418.1, AC010151.3, AC024080.2, AC008444.4, AC002340.2, AE003833.1, AE003798.1 , AF035218.1, AC006249.1, AC004657.1, AF027868.1, AL031661.28, AL161587.2, ALl 17188.1, AL049845.7, AL031431.8, AL022239.1, U22110.1 , D90899.1 , Z79479.1, AB020865.1, Z34519.1 , Z99114.1, AW501546.1, W28259.1 , W27092.1, AW371635.1, AL042125.1, AA61 1522.1, AA614931.1, AW748799.1, AAl 10819.1, Z28809.1, AW304131.1, AI371714.1, AW450989.1, AV162434.1, AI024379.1, AI288155.1, H24233.1, H16513.1, AW371421.1, AW496353.1, R40226.1, AA208526.1, AA075857.1, AA543909.1, AW501200.1, AW385206.1, AW760996.1, AW558606.I , AW558583.1 , AW298142.1, AW294127.1, AI874594.1, AI835959.1, AI788080.1, AV100560.1, AI537352.1, AI411951.1, AI410456.1, AA858493.1 , AI309599.1, AH 94657.1 , AH 82965.1, AI152676.1, AI144668.1, AI060676.1, AI046764.1, AA959394.1, AA940384.1, AA797665.1 , AA763173.1, AA717573.1, AA710050.1 , AA709538.1, AA561671.1, AA408328.1, AA285493.1, AA270256.1 , AA241245.1, AA230889.1, AA213293.1, AA104682.1, AA104275.1, AA104274.1 , AA087023.1, AA062156.1, AA061500.1, AA031128.1, AA028486.1 , AAO 11772.1, W63860.1, W34388.1, W18032.1 , W09805.1, AW694402.1, AW691053.1, AV213344.1, AV007100.1, AA892832.1, AA489256.1, T76002.1, AC015727.3, AC006338.3, AC007248.2, AC007039.3, AC006990.3, AC006983.2, AC053490.1, AC006982.1, AC036236.1, AC026852.1, AC020855.2, AC021307.3, AC010089.2, AC024353.2, ACOl 1753.2, AC020562.1, AC013575.1, AC011900.1, AL163760.1 ,

SEQ ID NO. 255 NGO-St-121 YS363/T7 3'

AC004148.1, AL157499.1, AL050211.1 , AC009275.5, AC008154.6, AE003690.1, AE003653.1, AC005524.1 , Z47358.1, X98238.1 , AI972322.1, AA193309.1, AA528241.1, AW235706.1 , AA527684.1 , AI436191.1, AA890512.1, AW299850.1, AA767452.1, AI580941.1, AI056055.1, AI130923.1 , AA283713.1, AI418205.1, AI056706.1 , AI808670.1 , AW137415.1, AI400431.1, AW295892.1 , AA846649.1 , AA960854.1 , AI222234.1 , AI084465.1 , AA479888.1 , AA917434.1 , AA960792.1 , AA290870.1 , AW089851.1, AI090024.1, AI078176.1, AA683232.1, AI023887.1, AA706411.1 , AA040801.1, AI632800.1, AI367258.1, AA693619.1, W15394.1, T03894.1 , AI955173.1, AI269900.1, AA218890.1, AI669191.1 , AA760918.1, AI826582.1, AI910510.1, AW082288.1 , N52967.1, Z39660.1, Z28661.1, W58520.1, AA954763.1, R50797.1 , AA041239.1 , H90518.1, AI349313.1, AI301633.1, AA412174.1, AI800039.1 , F26651.1, AW235792.1, AA621533.1, AA194263.1 , AI932942.1 , H09347.1 , AI953061.1 , R40788.1 , AW752307.1 , A A216603.1 , AW351827.1 , H73642.1 , Z28597.1 ,

AWl 37802.1 , H51737.1 , N45966.1 , AW576920.1 , Z20686.1 , Z28596.1 , Z24941.1 , AA425331.1, N44279.1 , AA766379.1 , AI742337.1 , AA426446.1 , AI696486.1 , Z72398.1 , D20547.1 , AA778438.1 , AV331582.1 , AW046470.1 , AA472952.1 , AA120705.1, AV357525.1, AA409778.1, AC016370.4, AC026940.2, AC026455.2, AC015932.4, AC019267.3, AC018853.3, AC009074.2, AC009201.3, AC022549.1, AC014455.1, AC017510.1 , AC006491.23, ACOl 1631.1, AL157823.3, AP001847.1, Z92859.1,

SEQ ID NO.256 NGO-St-122 YS1742/T3 5' NM_005089.1 , D49677.1, U51224.1, D49676.1, AC004106.1, NM_009453.1, D45205.1, NM_011663.1 , S69507.1, D26474.1, D17407.1, U92882.1 , Z74476.1, AC002530.1, U80017.1, AL031767.13, AL133100.1, AL096854.5, Z99279.1, M83200.1, AP000002.1, AK000538.1 , NC .001139.1 , AC005250.1, AC003074.1, AC004451.1, AC004882.2, AC007402.3, AC009992.5, AC004947.2, AF098999.1, AL121754.18, U60414.1, U62631.1, U57971.1, AB013003.1, AB013004.1, AP000173.1, AP000333.1 , AW866867.1, AI417175.1, AW371109.1, AW137848.1, AI200960.1, N80309.1, AA845804.1, AA320008.1, AA028127.1, AA028151.1, AA814970.1, AA814962.1, AA920561.1, AA33101 1.1 , AW364105.1, AI598939.1, AWl 44684.1, AW356771.1, AW805221.1, AI472111.1, AW345188.1, AW535394.1, AI576737.1, AI454541.1, AH 12465.1, AA601026.1, AH 12441.1, AI663887.1, AA388471.1, AW383892.1, AV357914.1, AW826265.1, AW613523.1, AW514825.1 , AV331731.1, AWl 17909.1, AV149324.1, AV124185.1, AV036810.1, AA841469.1, AA771282.1, AA507133.1, AA199064.1, Z74661.1, W27716.1, AV440680.1, AW671805.1, AW569275.1, AV359278.1, AV212567.1, AW039499.1 , AI989107.1, AI946720.1, AI868501.1, AVI 17593.1, AI763597.1, AV062802.1, AI755024.1, AV032630.1, AI648156.1, AI594159.1, AI466310.1, AI452794.1, AI412501.1 , AI381209.1, AI232722.1, AI101718.1, AI011347.1, AI266800.1, AH 14436.1 , AI058893.1, AA807323.1, AA763112.1, AA709977.1, AA600133.1, AA545349.1, AA519216.1, AA452591.1 , AA424001.1, AA329479.1, AA326345.1, Z81248.1, AA078585.1, C07041.1 , C06862.1 , C06853.1, H34402.1, AC008536.5, AC008461.4, AC008812.6, AC008763.4, AC017027.4, AC016287.3, ACOl 1257.3, AL136314.4, AC025259.4, AC068227.1, AC020985.4, AC018429.3, AC019244.2, AL1391 13.4, AL137004.2, AC069141.1, AC063954.2, AC046141.3, AC007641.10, AC067960.2, AC018728.2, AC009245.8, AC027495.2, AC025669.2, AC044808.1, AC023841.2, AC023421.2, AC026513.2, AC015916.3, AC019049.2, AC016814.3, AC011985.3, AC018671.5, AC016503.2, AC021329.3, AC021563.1, ACOl 1094.2, AL121983.7, AL157361.6, AL139419.1. AP000654.1,

SEQ ID N0.257 NGO-St-122 YS1742/T7 3' NM_005089.1, AC004106.1, D49677.1, U51224.1 , D49676.1, NM_011663.1, NM_009453.1 , S69507.1, D45205.1,

D26474.1, D17407.1, AL031317.1, AL139078.2, AB026659.1, AW194326.1, AW089584.1, AI991464.1, AI828556.1, AA430135.1, AA723697.1, AI634052.1, AW237119.1, T67521.1, AA377829.1, AW515964.1 , AA569819.1, T67543.1, AA601026.1 , AA669459.1 , AW609046.1 , AI663908.1 , AI663887.1 , AI893901.1 , AI636519.1 , AI632192.1 , H41170.1 , AC008536.5, AC008461.4, AC008451.3, AC040954.1, AC007569.8, AC027671.2, AC016823.4, AC021594.3, AL138881.4, AP001641.1,

SEQ ID N0.258 NGO-St-123 YS1702/T7 3^* U40705.1, AF043911.1, NM_003218.1, U74382.1, AF003001.1, AC006572.2, AL163204.2, NM_009352.1, U65586.1, X93511.1, U70993.1 , L63545.1 , AC004484.2, AC004617.1 , U47029.1 , D83257.1 , Yl 7297.1 , ACOl 1738.4, AE003685.1 , NM_009263.1, AL033534.1, Z47809.1 , S78177.1, XI 3986.1, X51834.1, X16151.1 , JO4806.1, NC_001 145.1, AC004667.2, AE003478.1, AE003432.1, AC002080.1, AC004964.2, AC007285.3, Z36238.1, Z48618.1, AL036326.1, AA467901.1, N68057.1, AW772242.1 , AI394003.1, AA135978.1, AA135764.1, AA467846.1, T76958.1, AA463246.1, AW152089.1, F13251.1, AW088675.1, R7091 1.1, AW860774.1, AA468251.1, AL046407.1, AI347136.1, AA317158.1, AI524143.1, Z45971.1, AI144010.1, AA207271.1, T63517.1, AI802125.1, AA468235.1, AI689994.1, AI680979.1, AW003979.1, AA529658.1, R68526.1 , AI125634.1, AW197488.1, AI088591.1, AA204808.1, AI989793.1, Z19923.1 , AI553354.1, R25990.1, AI313657.1, AI313655.1, AW367580.1, AI653818.1 , AA982217.1 , AW822952.1 , AW413558.1, AW413468.1, AW412565.1, AW412480.1, AW411784.1, AW261735.1, AW260247.1, AW260085.1, AW259661.1, AW240668.1, AW240555.1, AW215800.1 , AW212687.1, AW209307.1, AW209207.1, AW209119.1, AW208838.1, AWl 13907.1, AI987812.1, AI929854.1, AI891858.1, AI875465.1, AI875197.1 , AI847805.1 , AI839505.1, AI802541.1, AI790405.1, AI78861 1.1, AV017671.1, AV001287.1 , A1648742.1, AI647513.1, AI528600.1, AI325605.1, AI282135.1, AI182295.1, AI132382.1, AU021551.1, AI043071.1, AI043053.1, AI042865.1, AI035296.1, AA986704.1, AA980925.1 , AA839469.1, AA798241.1, AA789592.1, AA591084.1, AA563324.1, AA537448.1, AA145872.1, AA122501.1, AA073811.1, W08572.1 , AL137013.3, AL050303.2, AC022893.2, AF164115.1 , ACOl 1941.4, AC012670.2, AL162851.3, AC068925.1, AC023087.3, ACOl 1904.2, AC024067.3, AC024095.6, AC021771.2, AC018453.3, AC015364.1, AC017348.1, AC008172.1, AC055808.2, ACOl 1346.3, AC017014.3, AC026903.2, AC016486.4, AC012288.2, AC012602.2, AC014153.1, AL139162.3, AL009027.1 , SEQ ID NO. 259 NGO-St-124 YS033/T3 5'

AF039690.1, AF161348.1, AC006041.2, AC004636.1, AE003598.1, AE003485.1, NM_007186.1, AC005694.3, AC005529.7, AC005527.3, AC006221.1, AC004755.1, AF049105.1, AF022655.1, AL121586.28, Z47074.1, AP000965.2, U48937.2, AE003029.1 , AF163441.1, AF123008.1, AF123007.1, AF122994.1, AF092091.1, AL137686.1, Z82185.1, AL035070.3, AJ01 1930.1, AP001068.1, AP001067.1, M98498.1, W29097.1, AI092201.1 , AA690806.1, AA155014.1, AV127431.1, AA089195.1, AI967815.1 , AI865255.1, AV359357.1, AV328696.1, AV287587.1, AV313495.1, AV272703.1, AV233789.1 , AV233050.1, AA143515.1, AW708128.1 , AW368913.1 , AV338709.1 , AV332139.1, AV290604.1, AV323766.1, AV027087.1 , AI240775.1 , AH 70252.1, AI038890.1 , AW679928.1 , AW584240.1, AW581584.1 , AW581582.1, AW573270.1 , AW518642.1, AW516804.1, AW436684.1, AW369753.1, AW341252.1 , AV354655.1, AW134807.1, AI969272.1, AI949771.1, AI948870.1, AI924168.1, AI914290.I , AI892918.1, AI871649.1 , AI832248.1 , AI830664.1, AI824895.1, AI819076.1, AI819130.1 , AL037429.1, AI796870.1, AI769675.1, AI717994.1, AI708155.1, AI700048.1 , AI697939.1 , AI697687.1 , AI689763.1 , AI660476.1 , AI655335.1 , AU059236.1 , AI621281.1 , AI394537.1, AI379706.1, AI341342.1 , AI304914.1, AI301627.1, AI300957.1, AI299037.1 , AI298964.1 , AI292090.1, AI290292.1, AI224563.1, AI167134.1, AI146249.1, AI140672.1, AI089910.1, AI039908.1, AI016407.1, AA995707.1, AA973566.1 , AA967806.1 , AA938631.1, AA907234.1 , AA780678.1 , AA742364.1 , AA682624.1 , AA591111.1, AA452630.1, AA252245.1, AA252941.1, AA242923.1, AA153891.1, W65797.1, W05501.1 , N70619.1, D81647.1, AC024509.2, AL355978.2, AC019168.3, AC023267.2, AC024691.2, AC00901 1.2, AC034307.2, AC022983.2, AC015865.1, AC013902.1, AC017166.1, AC006839.13, AL139226.14, AC035146.2, AC007640.2, AC012411.3, AC021822.3, AC013829.4, AC021670.2, AL162453.4,

SEQ ID NO. 260 NGO-St-124 YS033/T7 3'

AF039690.1, U79271.1, ALl 17525.1, AC009479.3, AC005358.1, AFl 36378.1, AC005081.2, AF045555.1, AL031650.21 , AC006919.5, AC010967.2, AC008056.6, NM H2776.1, AC005386.1, NM_001619.2, U42580.2, AC007538.5, S81843.1, U08438.1, Z68282.1, AL121757.7, AL049544.4, AL031681.13, S48813.1, U39674.1, L23127.1, M34073.1, M80776.1, X61157.1 , AB025639.1 , M74822.1 , M87854.1 , X53421.1, AI735499.1 , AW028371.1, AI445418.1 , AI266387.1 , AI288955.1 , AWl 93663.1 , AI298467.1 , Al 168222.1 , Al 148323.1 , AH 40814.1 , AI089322.1 , AA879456.1 , AA84381 1.1, AA829894.1, AA102109.1, AA029201.1, W72147.1, N51485.1, AI808317.1, AI033069.1, AA161465.1, AA812519.1, N64528.1, H99906.1, AA886109.1 , R71679.1, AI970343.1, AA744290.1 , A W021346.1, AA099913.1, AW195719.1, AI267979.1, AA083859.1, AI038590.1, N51277.1, AA883684.1, R07471.1, H98684.1, R36854.1, F25334.1, R39448.1, AA083954.1 , R54092.1 , H09074.1 , AA346369.1 , AA910762.1 , AW873705.1 , N21975.1 , D59844.1 , AWl 95087.1 , H 11525.1 , AA971254.1 , W77907.1 , W29097.1 , AW057648.1 , AL041060.1 , AI659852.1 , AA878973.1 , AW392482.1 , AI057361.1, AA715235.1, F35739.1, AW427844.I , AW022199.1, AI963422.1, AA860455.1, AA026096.1, T26899.1, AI481 147.1, N71178.1, AW413553.1 , AW046739.1, AI529534.1, AI661769.1, AA269966.1, AI614472.1, AA026516.1, AI713205.1. AI575014.1, AH 12396.1, AI073194.1, AI651890.1 , AI575171.1, AA466212.1, AW181975.1, AI888595.1 , AV162955.1, AI452798.1, AI167638.1, AW495689.1, AI397450.1, AW547034.1, AW479264.1 , AC024079.2, AC022960.2, AL161723.3, AP001333.1, AC044855.2, AC060801.2, AC018648.2, AC068004.1, AC009623.3, AC013699.2, AC021912.3, AC018685.5, AC016675.4, AF202962.1, AL139349.16, AL132661.15, AL117190.2, AC010798.6, AC037488.2, AC036143.2, AC034212.3, AC008377.3, ACO 18640.1 , AC009444.2, AC025803.2, AC021417.3, AC026750.2, AC024242.2, AC026809.1, AC022882.3, AC016721.4, AC024342.2, AC009923.3, AC022828.2, AC023002.1, ACOl 1237.3, AC017078.3, ACOl 1290.2, AL080314.29, AL163540.3, AL162632.1, AL353713.1, AL158068.4, AL159973.2, AL133501.1, AP001586.1, AP001023.1, AP00O425.1,

SEQ ID N0.261 NGO-St-124 YS173/T3 5' AF039690.1, AF161348.1, AC006615.1, AC006041.2, AC004636.1, AB006709.1, AE003598.1, AC005070.1 ,

AC007632.4, AC005041.2, AC006221.1 , Z47074.1, U48937.2, AC007019.4, ACOl 1751.2, AF145727.1, AF164622.1, AF163441.1, AF204231.1, AC010870.4, AC005589.1, AC008072.3, AF092091.1, AF009623.1, AC004048.1, AC004257.1, AL163300.2, AL137686.1, U88309.1, AL021492.1, Z46787.1, Z94057.1, AL035070.3, AP001819.1, AJ01 1930.1, AP001068.1 , AP001067.1, AB029041.1, AB020662.1, D84549.1, M98498.1, AI092201.1, AA155014.1, W29097.1, AW150169.1, AV127431.1, AA089195.1, AI606060.1, AI967815.1, AV359357.1, AV328696.1, AV287587.1, AV313495.1, AV272703.1, AV233789.1, AV233050.1, AA690806.1, AW708128.1, AV338709.1, AV332139.1, AV290604.1, AV323766.1 , AV027087.1, AI240775.1, AI170252.1, AW679928.1, AW584240.1, AW581584.1, AW581582.1, AW369753.1, AV354655.1, AL044559.1, AL037429.1 , AU059236.1, AA780678.1, D81647.1 , AC024509.2, AL355978.2, AC019168.3, AC023267.2, AC024691.2, AC018403.4, AC00901 1.2, AC012473.5, AC012487.3, AC006724.1 , APOO 1523.1, AC037470.2, AC040171.2, AC009636.3, AC025660.2, AC022983.2, AC023750.1, AC015865.1, AC016040.2, AC017166.1, AL354654.1, AL138479.1,

SEQ ID N0.262 NGO-St-124 YS173/T7 3'

AF039690.1, U79271.1, ALl 17525.1, AF136378.1, AL031650.21, X79703.1, AC006919.5, AC008056.6, NM_012776.1, NM_001619.2, AF193021.1, AC007538.5, S81843.1, AF121782.1, AF064857.1 , AL163281.2, AL133283.9, U08438.1, Z50044.1, Z68282.1, AL121757.7, AL049544.4, AL031681.13, S48813.1, U39678.1 , U39674.1, L23127.1, M34073.1, M80776.1 , X61157.1 , M74822.1 , M87854.1 , X53421.1 , AI735499.1, AW028371.1 , AI445418.1 , AI266387.1 , AI288955.1 , AW193663.1, AI298467.1, AI168222.1, AI148323.1, AI140814.1, AI089322.1, AA879456.1, AA843811.1, AA829894.1 , AA102109.1, AA029201.1, W72147.1, N51485.1, AI808317.1, AI033069.1, AA161465.1 , AA812519.1, N64528.1 , H99906.1, AA886109.1, R71679.1, AI970343.1, AA744290.1, AW021346.1 , AA099913.1, AW195719.1, AI267979.1, AA083859.1, AI038590.1, N51277.1 , AA883684.1, R07471.1, H98684.1, R36854.1 , R39448.1, F25334.1, AA083954.1, R54092.I , H09074.1, AA346369.1, AA910762.1, AW873705.1, N21975.1, W29097.1, D59844.1, AW195087.1, HI 1525.1, AA971254.1, W77907.1, AW057648.1, AL041060.1, AI659852.1, AA878973.1, AW392482.1, AI057361.1, AA715235.1, F35739.1, AW022199.1, AW427844.1, AA860455.1, AI963422.1, AA026096.1, AI481 147.1, T26899.1, AW413553.1, AW046739.1, AI529534.1, AI661769.1, AA269966.1 , N71 178.1 , AI614472.1, AI713205.1 , AI575014.1, AH 12396.1, AI073194.1, AA026516.1, AI651890.1, AI575171.1, AA466212.1, AV162955.1, AA690806.1, AI397450.1 , AC022960.2, AP001333.1, AC044855.2, AC060801.2, AC018648.2, AC068004.1 , ACO 13699.2, AC026224.1, AC021912.3, AC018685.5, AF202962.1, AL139349.16, AL132661.15, ALl 17190.2,

SEQ ID N0.263 NGO-St-125 YS3710 T3 5'

AF099990.1 , AF068261.1 , D88190.1 , AC005950.1 , ACOO 1228.1 , D64137.1 , NM_002840.1 , AF099988.1 , ALl 37556.1 , Y19224.1, Y00815.1, NM_000076.1, AC024753.1, AE003481.1, AE003458.1, NM_002653.I , AF109719.2, AC004367.1 , AF009648.1, AL157480.1, Z83844.5, U48869.1, U22398.1, AB018791.1, NM_014961.1, AE003669.1, AFl 12221.1, AC00581 1.10, AF082296.1, AC004466.1, AL008583.1, AK000911.1, AB020678.1, M63356.1, AE003487.1, AF047034.2, AF071810.1, AC004797.1, U09808.1, AE003663.1, U90653.2, NMJH2699.1, AC022517.1, AF071813.1 , AC004876.2, AC005259.1, L81775.1 , X95703.1, X98993.1, X62681.1, AF189262.1, NM_014341.1 , AF176006.3, AF192559.3, NM_013024.1, AF189289.1, AF071815.1, NM_009453.1, NM_006460.1 , AC007395.3, AF139177.1, U86410.1, M83196.1 , U40628.1 , U40627.1 , X00618.1, AL031107.1 , J02675.1 , AB021179.1 , D45205.1 , D83484.1 , X00254.1 , X76232.1, M63348.1, U03771.1, AF255552.1, AF168787.1, AC007774.1, AC006486.1, AJ004801.1 , Z77662.1, AL136295.2, U14656.1, AW070197.1, AI873022.1 , AW575715.1, AW271726.1, AW172297.1 , AW170107.1, AI524194.1 , AI652188.1, AI623209.1, N95583.1, AA283710.1, AA573499.1, AI674687.1, AA694439.1, AI760975.1, AA731091.1, AI230984.1, AA805306.1 , AA927565.1, AW369632.1, AI425458.1 , AI578926.1, AI043684.1, AA851538.1, AA221745.1, AW028244.1, AI873396.1, AI492967.1, AI192683.1, AI854240.1, AI850380.1, AI575971.1, AI461919.1, AW0471 18.1, AA997145.1, AI008247.1, AA408914.1, AA408939.1, AA402099.1, Cl 1942.1, AA305260.1, AW869895.1, AJ272945.1, AI429741.1, AW595481.1, AI595277.1 , AI327425.1 , AA481582.1 , AA061204.1 , W98922.1 , AV408902.1 , AW696319.1 , AW677099.1 , AW5131 14.1 , AW280634.1 , AW280527.1 , A W243892.1 , AWl 93511.1 , AI852364.1 , AI803180.1 , AI784610.1 , AI671129.1, AI640998.1, AA998163.1, AA964571.1, AI159402.1, AW244421.1 , AW624533.1, AW593458.1, AW574954.1, AW149459.1, AW092856.1, AI987240.1, AI876971.1, AI356089.1, AI225774.1, AI166942.1, AA791749.1 , AA544523.1, W16147.1, W18003.1 , W13961.1, N42977.1, H19168.1, AC013791.3, AC010216.4, AC008470.3, AC023467.2, AL355519.2, AC025716.1, AC008350.3, AC010714.3, AC020195.1, AC008232.3,

AC006903.1, AC006727.1, AC006751.1, Z98864.1, AC008406.5, AC014744.1, AC024725.3, AC026968.2, AC021248.3, AC014187.1, AC014191.1, AL035406.22, AC021024.3, AC009570.7, AC034220.3, AC021091.2, AC009061.8, AC027682.2, ACOl 1430.4, AC007732.2, AC026759.1, AC00991 1.9, AC010848.12, ACOl 1707.7, AC021618.3, AC019638.1, AC014137.1, AC014975.1, AC010024.2, AC007831.1, AL121908.11, AC024215.7, AC068810.1, AC010648.5, AC022274.4, AC015462.5, AC022307.7, AC024047.2, AC024708.2, AC010003.5, AC009369.5, ACOl 1244.3, AC010703.2, AL122034.8, AL137066.5, AL354940.3, AL157708.2, AC027810.3, AC027796.3, AC058789.9, AC026270.2, AC016631.5, ACOl 1514.2, AC027800.2, AC067434.1, AC026167.2, AC027040.2, AC019234.3, AC012236.3, AC009915.4, AC024159.1, AC023852.1 , AC013273.2, AC020327.1, AC020433.1, AC020525.1, AC007925.4, AC017941.1, ACOl 8090.1 , AC008228.2, AC013124.1, AC013189.1, AC013210.1, AC014106.1, AC014400.1, AC015146.1, AC007822.3, AL031258.10, AL355153.1, AL080247.3,

SEQ ID NO.264

NGO-St-126 combined

AC067976.1, AC010763.2, AC067721.3, AC063926.3, AC026210.1, AC022240.2, AC025076.3, AP001541.1, AP000614.3, AC009543.4, AC026325.3, AC026317.5, AC02631 1.4, AC025580.3, AC012112.2, AC022926.2, AC020012.1, AC018212.1, AL137864.6, AL356371.1, AL356260.1, AC040919.1, AC044905.2, AC036192.2, AC023648.3, AC068679.1, AC027464.2, AC021200.4, AC012512.2, AC012164.10, AC017097.2, AC013273.2, AC012352.3, AC022183.2, ACOl 1018.2, AC018224.1, AC015182.1, AC009742.3, AF181895.1, AF128834.1, AL355143.4, AL354814.1, Z92852.20, AL021149.3, AP002000.1, AP001361.1, AP000786.1 , AP000785.1, AL021347.1, AI469428.1, AW004984.1, AW675448.1 , AW780423.1, AW239395.1, AW651755.1, AA535069.1 , AI378367.1,

AA879433.1, AA971454.1 , AI394371.1, AI564549.1, AA446421.1, AW553616.1, AA928053.1, N78225.1, AI431285.1, AA870109.1 , AW674657.1, AI364000.1, AA305698.1, AA760173.1, AW674987.1, AW087890.1, N59764.1, AW548602.1, AW881866.1, AA897396.1, AW673412.1, AW674408.1, AA056907.1, AI20201 1.1, AA213076.1, AI047089.1 , AW392852.1 , AI747290.1 , T36030.1 , AW544283.1 , Al 131751.1 , AW340239.1 , Tl 9014.1 , T96204.1 , R94457.1, AA518752.1, AH 15877.1, AH 19061.1, AA123206.1, AI753769.1, AI787898.1, AA765346.1, AI715715.1, AA999172.1 , AA221877.1, AI460161.1, T81090.1, C03806.1, N86797.1 , AW079585.1, AW672700.1, AW527002.1, AU076916.1, AI741285.1, R00722.1, AI892500.1, R00723.1, AA644165.1 , AI916149.1, AI482319.1 , AI325806.1, T81139.1, AA438060.1, AA561307.1, AI873729.1, AA561305.1, AV040805.2, AV235074.1, AV220284.1 , AI614757.1, AW275744.1 , AV265274.1, AV248478.1, AV245335.1, AV263802.1, AV270362.1, AV043755.2, AV048190.1, AV370590.1, D25791.1, AVI 14853.1, AVI 11421.1, AV256037.1, AI795876.1, AV374021.1, AV261192.1, AV320489.1, AV252321.1, AV366822.1, AV299835.1, AV312541.1, AA450537.1, AC067976.1, AC010763.2, AC067721.3, AC063926.3, AC026210.1, AC022240.2, AC025076.3, AP001541.1, AP000614.3, AC009543.4, AC026325.3, AC026317.5, AC026311.4, AC025580.3, AC0121 12.2, AC022926.2, AC020012.1 , AC018212.1, AL137864.6, AL356371.1, AL356260.1 , AC040919.1 , AC044905.2, AC036192.2, AC023648.3, AC068679.1, AC027464.2, AC021200.4, AC012512.2, AC012164.10, AC017097.2, AC013273.2, AC012352.3, AC022183.2, ACOl 1018.2, AC018224.1, AC015182.1, AC009742.3, AF181895.1, AF128834.1, AL355143.4, AL354814.1, Z92852.20, AL021149.3, AP002000.1, AP001361.1, AP000786.1, AP000785.1, SEQ ID NO. 265 NGO-St-126 YS136/T3 5'

NM_003875.1, U10860.1, X87562.1, AL139077.2, AB033168.1, AC007956.5, AE003718.1, NM_004879.2, AC004877.1, AF010313.2, AC006052.5, AL035671.5, NC_001139.1, AC020580.9, AC002382.1, AC006064.9, AC005895.1, Z72999.1, AL022328.21, AL049781.4, AL133068.1, AL133399.1, M88277.1, X59698.1, X78987.1, D90899.1, AB037724.1,

AK001986.1, AB023482.2, U03425.1, AB009050.1, AW239395.1, AW651755.1 , A W672700.1, AU076916.1, AH 19061.1, AW527002.1 , AI787898.1 , AH 15877.1 , AI614757.1 , AAl 23206.1 , AA450537.1 , AI892500.1 , AI325806.1 , AW372007.1 , AW367352.1, AI930281.1, AA561307.1, AA561305.1, AW732597.1, AW732373.1, AW248209.1, AV300605.1, AW16331 1.1 , AV204617.1, AI550018.1, AW699234.1, AW653532.1, AW653462.1, AW336984.1, AW163624.1, AI929457.1, AI739490.1, AI069011.1, R58474.1, R57620.1, R46363.1, R14654.1, T38036.1, T33110.1 , Z43008.1, AC010763.2, AC026210.1 , AC044905.2, AC023648.3, AC019035.5, AC018958.2, AC013273.2, AC012669.2, AC018224.1, AC009742.3, AC012522.7, AC068285.2, AC021891.2, AC008692.4, AC010373.4, ACOl 1116.3, AC018696.3, AC024931.3, AC018996.3, AC009621.4, AC022213.3, AC021265.3, AC022930.2, AL133416.3, AL137161.3, AL137855.2, AL135924.10, AL080247.3,

SEQ ID NO.266

NGO-St-126

YS136/T73'

NM_003875.1, U10860.1, AC006380.2, AF006203.1, AC009396.5, Z50794.1, U21627.1, AI469428.1, AW004984.1 , AI564549.1, AW675448.1, AA535069.1, AI378367.1, AW780423.1 , AA879433.1, AI394371.1, AA971454.1, AI431285.1, AA928053.1, AW674657.1, AI364000.1, AA305698.1, AW674987.1, AW087890.1, AW673412.1, AI202011.1, N59764.1, AW674408.1, AI741285.1, AA056907.1 , AA897396.1, AW340239.1, AW553616.1, AW548602.1, AA870109.1, AW544283.1, AI131751.1 , AI753769.1, AI460161.1 , AA765346.1, AI715715.1, AA999172.1, AA221877.1, N78225.1, T81090.1, AW079585.1, R00723.1, AI747290.1, AI482319.1 , AA446421.1, AI873729.1, AW275744.1 , T96204.1, AV263802.1, AV235074.1, AV248478.1, AW881866.1, D25791.1, AV245335.1, AV370590.1, AV265274.1,

AV220284.1, AV040805.2, AVI 14853.1, AVI 11421.1, R94457.1, AV261192.1 , AV320489.1, AV048190.1, AV043755.2, AV270362.1, AV256037.1, AV374021.1, AV312541.1, AV366822.1, AV352771.1, AV299835.1, AV261104.1 , AV337229.1 , AV254627.1, AV257886.1, AV252321.1, AV261234.1, AV255806.1, AV380586.1, AV281906.1, AV283090.1, AW68I473.1, AV279890.1, R00722.1, AV359752.1 , AA218130.1, AV351363.1, T81139.1 , AW634678.1, AW634655.1, AV263948.1, AW766970.1, AW460442.1, BB001634.1, AW198719.1, AW148282.1, AV228798.1, AC067976.1, AC067721.3, AC024615.2, AC009550.3, AC037444.2, AC037467.2, AC027003.2, AC010679.3,

SEQ ID N0.267 NGO-St-126 YS1613/T3 5'

NM_003875.1, U10860.1, U67598.1, U39471.1, U28733.1, M64282.1, AE003537.1, AB012242.1, AC008993.3, AE003781.1, AC008063.2, AC005061.2, AC004605.1 , AC007090.3, AEOOl 176.1, AF067215.1, AL161532.2, AF016678.1, Z93778.1, Z30215.1, AC002109.1, AL078621.19, AL050399.1, U42844.1, AC000120.1, Z94044.1, AL035447.3, AP002067.1, X60691.1, M93038.1, M14115.1, M16632.1, M59809.1, M59810.1, M59808.1, M14707.1, AA760173.1, AI047089.1, AA518752.1, N86797.1, C03806.1, AA644165.1, T36030.1, T19014.1 , AA438060.1, AI916149.1, AA213076.1, AI795876.1 , AAl 23206.1, AA561308.1, AA561307.1, AA561305.1, AW392852.1, AW651755.1, AI325806.1 , AI892500.1, AI878306.1, AH 19061.1, R94029.1, AV346184.1, AW154885.1, AW031455.1, AW725845.1 , AW271459.1, AW201020.1, AV376365.1, AI990909.1, AVI 74444.1, AI353515.1 , AA909030.1, T70524.1, AC063926.3, AC067721.3, AC022240.2, AC009543.4, AC012112.2, AC022926.2, AL137864.6, AL356371.1, AL356260.1, AC025076.3, AC027464.2, AC015773.4, AC012512.2, AC020668.4, AC012352.3, AC015182.1, AF181895.1, AF128834.1, AP001541.1, AP000614.3,

SEQ ID NO.268 NGO-St-126 YS1613/T7 3'

NM_003875.1, U10860.1, AC006380.2, AF134842.1, AC002127.1, NM_004849.1 , AL022067.1 , Yl 1588.1, AC004450.2, AC009396.5, AC006145.2, AC003953.1, Z50794.1, X97212.1, AI469428.1, AW004984.1 , AW675448.1 , AW780423.1, AA535069.1 , AI378367.1, AA879433.1, AA971454.1, AI394371.1, AI564549.1, AA928053.1 , AI431285.1, AW553616.1, AW674657.1, AI364000.1, AA870109.1, AA305698.1, AW674987.1, AW087890.1 , N59764.1, AW548602.1, AA897396.1 , AW673412.1 , AA056907.1 , AW674408.1 , N78225.1 , AI202011.1, AW544283.1 , Al 131751.1 , AW340239.1 , AI753769.1, AI715715.1, AA765346.1 , AI747290.1, AA999172.1, AA221877.1, AI460161.1, AA446421.1, T81090.1, AW079585.1, AI741285.1, AW881866.1, T96204.1 , R00723.1, R94457.1, AI482319.1, AI873729.1, AV040805.2, AV235074.1, AV220284.1, AW275744.1, AV265274.1, AV248478.1, R00722.1, AV245335.1, AV263802.1, AV270362.1 , AV043755.2, AV048190.1, AV370590.1, D25791.1 , AVI 14853.1 , AVI 11421.1, AV256037.1, AV374021.1, AV261 192.1, AV320489.1 , AV252321.1, AV352771.1 , AV366822.1, T81 139.1, AV299835.1 , AV312541.1, AW681473.1, AV254627.1, AV261104.1, AV337229.1 , AV261234.1 , AV257886.1 , AV255806.1 , AV283090.1 , AV281906.1 , AV279890.1 , AV380586.1, AW634678.1 , AW634655.1, AV359752.1, AV351363.1, AV280423.1, AA218130.1, AV263948.1, AW460442.1, AW766970.1, W88512.1, AW484561.1, AI705688.1, AAl 12455.1, N94345.1, AC067976.1 , AC067721.3, AC025580.3, AL355980.2, AL162491.3, AC044895.1, AC021200.4, AL133509.7, AL138917.3, APOOl 361.1, AP000786.1, AC044809.3, AC026450.2, AC034188.2, AC025241.2, AC027415.1, AC026201.1, AC023147.3, AC024449.2, AC022004.2, AC022219.2, AC010987.4, AL136109.3, AL139230.6, AP001828.1, AP000653.1, AP000595.2, SEQ ID N0.269 NGO-St-126 YS1722/T3 5'

NM_003875.1, U10860.1, AE003669.1, AE003647.1, AE003413.1, AC006574.1, U39471.1, U28733.1, M64282.1, AF125313.1, AF101305.1, U85195.1, Z46935.1, AE000658.1, AL136297.2, AL035091.2, AP000064.1 , ABO 12242.1, AC007964.3, AE003566.1 , NM_004849.1, AC005061.2, AF125961.1, AC005988.1, AEOOl 176.1, U69730.1, AL161532.2, AL050399.1, ALl 33305.2, U97001.1, AL022342.6, AL022067.1, Z99127.1, Y 1 1588.1, Z59557.1 , AA446421.1, AW392852.1, AA213076.1, T36030.1, T19014.1 , AW881866.1, N78225.1, R94457.1, AI469428.1, AI916149.1, T96204.1, AA760173.1 , R00722.1, T81139.1, AI047089.1, AI747290.1, AW004984.1 , AW553616.1, AA518752.1, AA870109.1, AW675448.1, AI564549.1, AW780423.1, AA446419.1, AW548602.1, AA644165.1, AA438060.1, AI353445.1, AA305698.1, AI378367.1, AA879433.1, AA535069.1 , AW681473.1, AW127943.1, AI394371.1, AI431285.1, AA971454.1, AW674987.1, AW674657.1 , AW673412.1, AI364000.1, AI131751.1, AW544283.1, AI715715.1, AA999172.1, AI878306.1 , AI239160.1 , AA221877.1, AW846110.1 , AW846072.1 , A V346184.1 , AW826474.1 , AV376365.1, AW088646.1, AI622981.1, AI489164.1, AA909030.1, AA703095.1, AA676931.1, AA157391.1, AAl 12455.1, W01474.1, N94345.1, N36362.1, AC067721.3, AC067976.1, AC063926.3, AC025076.3, AP001541.1, AP000614.3, AC009543.4, AC026325.3, AC026317.5, AC026311.4, AC012112.2, AC020012.1, AC018212.1 , AL137864.6, AL356371.1, AC040919.1, AC068679.1, ACOl 1172.4, AC017097.2, AC022183.2, ACOl 1018.2, AL355143.4, AP002000.1, AP001361.1, AP000786.1, AP000785.1, AL021347.1, AC032026.3, AC024978.3, AC024402.3, AC024628.3, AC007777.3, AC068800.3, AC025243.3, AC041049.2, AC034110.2, AC068811.4, AC010738.3, AC046201.2, AC025433.3, AC022124.3, AC008857.4, AC008390.6, AC016596.4, AC055724.1, AC068079.1, AC009406.3, AC016336.3, AC025549.3, AC009420.2, AC021811.2, AC022213.3, AC016379.3, AC016563.2, AC020963.1, AC024396.1 , AC022272.2, AC016833.2, AC022864.1, AC013363.3, AC013014.1, AC012050.1, AL138849.6, AL161641.3, AL133509.7, AL353655.2, AL355076.1, AL353623.2, AL138917.3, APOOl 166.1, AP000945.2, AP000940.2, SEQ ID NO.270 NGO-St-126 YS377/T3 5'

NM_003875.1, U10860.1, X87562.1, AL139077.2, U67598.1, AE003718.1, AC004877.1, AC006052.5, Z93021.2, AL035671.5, Z83313.1, AC011508.4, AC002382.1, AF199339.1, AC005083.1, AC009525.3, AL049634.8, Z19155.1, AL163275.2, AL136167.8, AL049781.4, AL133399.1, Z83827.1 , AL035447.3, X59698.1, X78987.1 , D90899.1,

AP001730.1 , AP001433.1, AB037724.1, AP000158.1, AP000014.2, U03425.1, AW651755.1, AW239395.1, AH 15877.1, AH 19061.1, AI787898.1, AA123206.1, AW527002.1, AI892500.1, AI325806.1 , AA561307.1, AA561305.1, AI614757.1, C03806.1 , AW672700.1 , AA450537.1 , AA561308.1 , N86797.1 , AW372007.1 , AU076916.1 , AW367352.1 , AI930281.1, AI878306.1, AI045575.1, AV300605.1, AV204617.1, AI550018.1, AW699234.1, AW653532.1, AW653462.1, AW361093.1, AW163624.1, AV160657.1, AI06901 1.1, AA813333.1, AA772484.1, AA751742.1 , AA227692.1, N28842.1, R58474.1, R57620.1, R46363.1, R14654.1, T33110.1 , Z43008.1, AC010763.2, AC008011.8, AC044905.2, AC046144.3, AC023648.3, AC027464.2, AC012164.10, AC013273.2, AC012352.3, AC018224.1, AC009742.3, AF181895.1 , AF 128834.1. AL354814.1 , SEQ ID N0.271 NGO-St-127 YS263/T3 5'

NM_014753.1 , D80009.1, AC024843.1, AF093673.1, AC009784.2, AF063097.1, AL031386.1, NM_007187.1, AC006004.1, AC007007.2, AF157835.1, AC007202.2, AC005275.1, AC005833.1, AF071185.1 , AC005221.1, AL161496.2, AL031634.1, AL121754.18, ALl 18516.10, AL022345.2, AL050321.8, AJ238786.1, AK001557.1,

AK000979.1, AB018116.1, AJ012750.1, W23168.1, AI733771.1, AA129555.1, AI906333.1, AA659526.1, AA905330.1, AV189348.1, C65491.1, AI166512.1 , AW871663.1, AW497693.1, AW463327.1, AW463204.1, AV404894.1, AW352454.1, AW255263.1 , AI954303.1, AI728334.1, AI668682.1, AI376662.1, AI090140.1, AA999519.1, AA668944.1, AA509065.1, AA503500.1, AA427376.1, AA417429.1, N88168.1, AL023808.2, AL022344.1, AL031601.2, AC037447.2, AC022400.4, AL135925.3, AC025039.3, AC025268.2, AC055809.2, AL136982.1, AC024946.4, AC006888.2, AC009719.2, AC024379.2, AC027182.1, AC022939.2, AC020868.1, AC016788.4, AC024127.1 , ALl 33383.6, AC021024.3, AC068787.3, AC068757.2, AC023600.13, AC027645.3, AC021104.2, AC067748.3, AC027108.2, AC023155.4, AC017090.3, AF252826.1, AC025385.2, AC02721 1.1, AC024073.2, AC023178.3, AC021839.3, AC024722.2, AC021 1 14.3, AC018443.5, AC017001.4, AC021761.3, AC023873.2, AC023854.2, AC010672.4, AC022566.1, AC016042.2, AC012559.6, AF215848.1 , AC007689.12, AC016158.2, AC01091 1.1, AC010073.1, AL158143.2, AL158089.6, AL354975.4, AL136079.3, AL355530.1 , AL354857.2, AL161775.3, AL158217.3, AL157877.5, AP001827.1, AP000643.1 , Z96803.1 , SEQ ID NO.272 NGO-St-127 YS263 T7 3'

NM_014753.1, D80009.1, AE003451.1, ACOl 1294.3, Z85996.1, AC007244.2, AJ271079.1, M22462.1, AE003815.1 , AE003364.1, AC004963.2, AF153352.1, AC007068.17, AE001389.1, Z78067.1, AP000419.1, L15320.1, AC007042.2, AC006544.19, AF135026.1 , AE003557.1 , AE003528.1, AC003060.1, AF228703.1 , U91325.1, AC004832.3, AC004876.2, AC007368.1 1, AC007461.8, AC004950.2, AC005033.1, AC003065.1, AC005548.1, U21933.1 , AF010237.1, AC004167.1, AC004104.1, AC002324.1, AE001032.1, AL050342.42, Z98949.1, Z77662.1, Z50015.1, AL022315.1, AL121723.36, AL157498.1, AL137325.1, U31447.1, AL023800.1, L19655.1, AP000475.3, M73822.1, APOOl 111.1, AP000023.1, AB028621.1, D87018.1, AB029018.1, AC006481.3, AF050157.1, AL121656.2, AL022310.1, AB016885.1 , AW237092.1, AW237137.1, AI935281.1, AW467637.1, AI963620.1, AI650475.1, AI628080.1, AA927690.1, AI338027.1, AI590556.1 , AA604575.1, AA203521.1, AI281023.1, AI609068.1, AI689223.1, AW058425.1, AA483799.1, AW473973.1, AA278635.1 , AW083923.1, AA915891.1, AA766731.1, AI984984.1, AW803966.1, AI281 118.1, AI131367.1, AI537394.1, AI278563.1, AA159506.1, AI304815.1, AI033401.1 , AI049943.1, AW004875.1 , AA047286.1, T87897.1, AW029023.1, AA480172.1, AI285145.1, AA252803.1, AA261816.1, AI867812.1, AA554061.1, AI753409.1, W81534.1 , AI015310.1, AA099000.1, T87990.1, AI184520.1, R00576.1, AI824434.1, AL047806.1 , W81533.1, T79535.1, AA047147.1, R33795.1, AA864952.1, AI149983.1, R00680.1, AI810930.1, AW263579.1, AI866914.1, T97738.1, AW796065.1 , AA278634.1, AI802574.1, AI651401.1, AW004034.1, AW175987.1, AI005967.1, AA793158.1, H62063.1, AA571438.1, AI376279.1, AA623849.1, AW194865.1, AW428271.1 , AWl 75972.1, AA616918.1, AW205363.1, AA762572.1, AA223495.1, H61156.1 , AA421215.1, AA411512.1, AA405999.1, AA293345.1, AA555719.1, T97844.1, AA914529.1 , AA726890.1, AA262513.1, AA058106.1, AW910545.1 , AW416674.1, AW416666.1, AI406390.1, AA421216.1, AA411513.1, AA399425.1, AW523356.1, AL022344.1, AL023808.2, AC036220.3, AC023099.2, AC022264.2, ACOl 1753.3, AC023723.2, AC014984.1, AC009785.4, ACOl 1191.3, AC013532.2, AC025638.3, AC010033.7, AC068739.2, AC034244.3, AC008481.6, AC027517.2, AC036185.1 , AC015925.3, AC015724.4, AC019168.3, AC017420.1, AC013378.3, AC007107.1 , AC02501 1.2, AC022061.3, AC012431.6, AC015990.5, AC058333.2, AC020904.5, ACOl 1543.3, ACOl 1491.4, AC018880.2, AC021111.3, AC024638.2, AC022297.7, AC017059.2, AF215848.1, AL158846.3, AL139404.2, AL139110.2, AL121828.8, AL161618.5, APOOl 102.2, AP001005.1, AP000813.1,

SEQ ID NO.273 NGO-St-127 YS324 T7 3'

NM_014753.1 , D80009.1, AE003451.1 , Z85996.1, AC007244.2, AJ271079.1, M22462.1 , AC004963.2, AF153352.1, AC007068.17, Z78067.1, Z83844.5, AL078477.5, AP000419.1, LI 5320.1, AC007042.2, AC006544.19, AFl 35026.1, AC027657.1, AE003557.1, AF228703.1, AC004832.3, AC004876.2, AC005003.2, AC006371.2, AC008078.1 1, AC008010.10, AC007368.11, AF134488.1 , AC004961.2, AC007461.8, AC006432.15, AC004950.2, AC002082.1 , AC005033.1, AC003065.1, U21933.1, AF010237.1, AC004167.1, AC004104.1, AC002324.1, AE001032.1, Z98949.1, Z77662.1, Z50015.1, U93037.1, AL022315.1, AL121723.36, AL031767.13, AL049838.3, AL157498.1, AL137325.1, U31447.1 , AL023800.1, AL031665.18, L19655.1, AB040962.1, M73822.1, APOOl 111.1, AP000023.1, AB028621.1, AB005049.1, AB029018.1 , NM_001702.1, NM_013146.1, AL121656.2, AL022310.1, U18419.1 , X54171.1, AB005297.1 , AI963620.1, AW467637.1, AW237092.1, AW237137.1, AI628080.1, AI935281.1, AI650475.1, AI338027.1, AA604575.1, AA927690.1, AI609068.1, AI590556.1, AI281023.1, AW058425.1, AI689223.1, AA203521.1 , AA483799.1, AW473973.1, AA278635.1, AA915891.1, AW083923.1, AA766731.1, AI984984.1, AI281118.1, AI131367.1, AI537394.1, AI278563.1 , AA159506.1, AI304815.1, AI049943.1, AI033401.1, AW004875.1, AI285145.1 , AA047286.1, AW803966.1, AW029023.1 , T87897.1 , AA480172.1 , AA252803.1 , AA261816.1, AI753409.1 , AI867812.1 , W81534.1 , AA554061.1, AI015310.1, AA099000.1, AH 84520.1, R00576.1, AI824434.I , T87990.1, AA047147.1 , AI866914.1, AA864952.1, R33795.1 , AH49983.1 , AI810930.1, T79535.1 , AI802574.1, AW263579.1, T97738.1, R00680.1, W81533.1, AW004034.1, AL047806.1, AW194865.1, AI376279.1, AI651401.1, H62063.1, AW205363.1, AW428271.1, H61156.1, AA421215.1 , AA41 1512.1, AA405999.1 , AA293345.1, AA223495.1, AW796065.1, AA278634.1, T97844.1, AA421216.1, AA411513.1 , AA399425.1, AA455122.1, AA402812.1, AA402916.1 , AA402630.1, AW523356.1, AW522183.1, AW469155.1, AW469154.1, AW469148.1, AI406390.1, AW910545.1, AI005967.1, AA623849.1, AA408648.1, W77672.1 , AA914529.1, AA793158.1, AA571438.1 , AL022344.1, AL023808.2, AC036220.3, AC023099.2, AC022264.2, AC011753.3, AC023723.2, AC014984.1 , AC022146.3, AC009785.4, AC011 191.3, AC013532.2, AC010033.7, AC068739.2, AC034244.3, AC008481.6, AC036185.1, AC025473.2, AC015925.3, AC015724.4, AC023857.2, AC025011.2, AC022061.3, AC012431.6, AC015990.5, AC009757.8, AC018634.2, AC058333.2, AC040949.2, AC021893.10, AC012640.4, ACOl 1491.4, AC026040.3, AC021111.3, AC025749.2, AC009899.5, AC013391.3, AC018679.5, AC022297.7, AC023325.2, AC022908.2, AC017059.2, ACOl 1329.5, AC014174.1, AC010826.2, ACOl 1098.1, AL158846.3, AL139404.2, AL137004.3, AL137793.2, AL133402.10, AL121828.8, AL161618.5, AL161739.2, AL161448.3, AP001936.1, APOOl 102.2, AC009857.2, AC026077.3, AC022258.3, AC021240.3, AC023451.2, AC013609.2, AC014418.1 , AC007118.1, AC0031 15.1, AC003118.1, AL138846.3, SEQ ID NO.274 NGO-St-127 YS345/T7 3'

NM_014753.1, D80009.1, AE003451.1, AC011294.3, Z85996.1 , AC007244.2, AJ271079.1 , M22462.1, AE003815.1, AE003418.1 , AC004963.2, AF153352.1, AC007068.17, AE001389.1, Z78067.1, AL132792.2, AP000419.1, L15320.1, AC007042.2, AC006544.19, AF135026.1, AC027657.1, AE003557.1, AE003528.1 , AC003060.1 , AF228703.1, U91325.1, AC004832.3, AC008078.11, AC007368.11, AF134488.1, AC007461.8, AC004950.2, AC002082.1, AC005033.1, AC003065.1, AC005548.1, U21933.1, AF010237.1, AC004167.1, AC004104.1 , AC002324.1 , AE001032.1, AL050342.42, Z98949.1, Z77662.1, Z50015.1, AL022315.1, AL121723.36, AL031767.13, AL157498.1, AL137325.1, U31447.1, AL023800.1 , L19655.1, AB040962.1, AP000475.3, M73822.1, APOOl 111.1, AP000023.1 , AB028621.1, AB005049.1, AB029018.1, AC006481.3, AF050157.1 , ALl 21656.2, AL022310.1, AB016885.1, AW237092.1, AW237137.1, AI935281.1, AI628080.1 , AW467637.1, AI650475.1, AI963620.1, AI338027.1, AA927690.1, AA604575.1, AI281023.1, AI590556.1, AA203521.1, AI609068.1, AI689223.1, AW058425.1, AA483799.1, AW473973.1, AA766731.1, AA278635.1, AW083923.1, AA915891.1, AI984984.1, AI2811 18.1, AH31367.1, AI537394.1, AI278563.1, AA159506.1, AI304815.1 , AW803966.1, AI033401.1, AI049943.1, AW004875.1, AA047286.1 , T87897.1, AW029023.1, AA480172.1, AI285145.1, AA252803.1, AA2618I6.1, AI867812.1 , AA554061.1, AI753409.1, W81534.1 , AI015310.1, AA099000.1 , AI184520.1, R00576.1 , T87990.1 , AI824434.1, AA047147.1, R33795.1, AA864952.1, T79535.1 , AI149983.1, AI810930.1, AI866914.1 , AW263579.1, T97738.1, W81533.1, R00680.1, AL047806.1, AI802574.1 , AI651401.1 , AW004034.1 , H62063.1 , AI376279.1 , AWl 94865.1 , AW796065.1 , A W428271.1, AA278634.1 , AW205363.1 , AA223495.1 , H61156.1 , AA421215.1 , AA411512.1 , AA405999.1, AA293345.1, T97844.1, AWl 75987.1 , AI005967.1, AA793158.1, AA623849.1, AA914529.1, AA571438.1, AI406390.1, AA421216.1, AA411513.1 , AA399425.1, AA455122.1, AA402812.1, AA402916.1, AA402630.1, AW910545.1 , AW469155.1, AW469154.1, AW469148.1, AW523356.1, AW175972.1, AW522183.1 , AL022344.1, AL023808.2, AC036220.3, AC023099.2, AC022264.2, ACOl 1753.3, AC023723.2, AC014984.1, AC009785.4, ACOl 1191.3, AC013532.2, AC025638.3, AC010033.7, AC068739.2, AC008481.6, AC027517.2, AC036185.1, AC015925.3, AC015724.4, AC019168.3, AC017420.1, AC020219.1 , AC013378.3, AC007107.1, AC025011.2, AC022061.3, AC012431.6, AC015990.5, AC058333.2, AC036174.2, AC020904.5, ACOl 1543.3, ACOl 1491.4, AC026658.2, AC021 111.3, AC022297.7, AC012664.3, AC017059.2, AF215848.1, ACOl 1098.1 , AL158846.3, AL139404.2, AL1391 10.2, AL121828.8, AL161618.5, AL157699.2, AP001936.1, AP001005.1, AP000813.1, AC024232.2, AC008060.3, AC026077.3, AC021240.3, AC022518.2, AC023451.2, AC013609.2, AC014418.1, AC006738.1, AC003 U8.1, AL138846.3, AL136371.2,

SEQ ID N0.275 NGO-St-128 YS1714/T3 5' D83327.1, D83077.I, D84296.1, D84295.1, D84294.1, NM_009441.1 , AB008516.1, AJ001866.1, AL163273.2,

AP001728.1, AP001429.1 , AP000150.1, D83253.1, AP000009.2, AP000151.1 , AF099914.1, AL132992.2, AL132977.1, AC006017.2, AC010170.3, U67510.1, AL021684.1 , X60399.1, D64005.1, AB018108.1 , AC008865.3, AE003786.1, AE003627.1, AE003085.1, AF198444.1, ACO06367.3, AC005666.1, AC004053.1, Z82058.1, Z82278.1, Z19156.1, AL034408.2, AL049643.12, X69058.1, AB030387.1, X16640.1, AW510696.1, AWl 30658.1 , AI955031.1, AI365371.1, AW272845.1, AI655615.1, AI651380.1 , N75792.1, N22573.1, R49365.1, T65109.1, AA733976.1, AL044710.1,

AA968229.1 , AI834826.1, AI956999.1, AI935572.1, AA226473.1, Fl 1111.1, AI462554.1, AV373371.1, AV349801.1, AV348118.1, AA226308.1, BB006439.1, AV172670.1, AV348357.1 , AA387528.1, AA822624.1, N45260.1, AV331075.1, AI580340.1, H83303.1, AA612013.1, AA054190.1, AI508671.1, AW691731.1, AW690698.1 , AW637870.1, AW446918.1, AI662108.1, AI528491.1, AU033435.1, N50729.1, AC020718.3, AC009801.3, AC026848.2, AF206725.1, AC025470.3, AC026616.2, ACOl 1632.3, AL161426.3, AC068145.2, AC009685.3, AC024156.2, AC021196.3, ACOl 1260.4, AC015861.5, AC021000.3, AC007728.1, AC021983.1, AP001378.1, AC025412.3, AC068288.2, AC008905.5, AC026474.3, AC009131.4, AC034282.2, AC067842.1, AC015971.3, ACOl 1726.3, AC009671.3, AC024525.2, AC019359.3, AC025009.2, AC013450.4, AC009746.10, AC018485.6, AC016129.10, AC010667.9, AC023015.2, AC020798.2, AC025338.1, AC020183.1, AC012419.2, AL356317.1, AL133326.8, AL355392.2, AL356017.1, AL161745.5, AL162505.3, AL133241.3, ALl 17187.2, ALl 17331.1, AL031011.20, Z98859.1,

SEQ ID NO. 276 NGO-St-128 YS1714/T7 3' D83077.1, D84296.1 , D84295.1, D84294.1, D83327.1, AL163273.2, AP001728.1, AP001429.1, AP000151.1, D83253.1, AP000009.2, NM_009441.1, AB008516.1, AC007023.3, AL022395.2, AF037454.1, NM_008395.1, AC010283.5, AC007198.6, AC020717.3, AC005310.2, AC007955.4, AF090190.1, AC005008.2, AC005034.1, AF131865.1, AF064058.1, AF032967.1, U42213.1, AC005571.1, AC005224.1, AC005304.1, AL049832.2, L28005.1, AB017653.1, AP000463.1 , AB025607.1 , AB023656.1 , ABOl 1163.1 , AI336910.1 , AI337091.1, AW665117.1 , AI885338.1 , AL042620.1 , AA722789.1, AA743347.1, AA887657.1, AI678227.1, AI318428.1 , AW772752.1 , AA515769.1, AW341881.1 , AA554904.1, AAl 12857.1, AA083921.1, AW803145.1, AI568131.1, AW237011.1, AI657054.1, AI653679.1 , AL040434.1, AW612699.1, AA470557.1, AA662541.1, AA470510.1, AA502576.1, AA852823.1, AW629888.1, R13859.1, AL039361.2, AA021274.1, AW352731.1, AA722688.1, AI003122.1, AW488299.1, AA669782.1, H31610.1, AW525528.1, AA997915.1, AW743421.1, AI646427.1, AI145984.1, W50656.1, AW108450.1, AA794421.1, AI019132.1, H06584.1, AI666638.1, AA270792.1, AA417656.1, AW296426.1, AI838089.1, AW466371.1, AA308558.1, AI839685.1, AA048256.1, AV170771.1, AV136593.1, AI846084.1, Z42452.1 , AI412296.1, AV278830.1, AV319373.1 , AV332268.1, AV327734.1 , AV259825.1 , AV157173.1, AV378262.1, AV341338.1, AW245310.1, AW822071.1, AV326279.1, AAl 55001.1 , AI812831.1 , AA543759.1 , AW923586.1 , AW921274.1 , AW908406.1 , AW760328.1 , AW349130.1 , AW310768.1, AW258283.1, AW202374.1 , AI957871.1, AI931902.1, AI790763.1 , AA940042.1, AA839623.1, AA758570.1, AA739484.1, AA739481.1, AA387131.1, AAl 10637.1, AC012032.i l, AL139409.3. AL356276.1 , AC019259.3, AC025596.1, AC021573.4, AC068169.1, AL161450.4, AC026096.2, AC021484.3, AC012528.2, AC024127.1, AC019061.3, AL139134.4, AL355876.2, AC025076.3, AC037466.3, AC046139.4, AC012506.4, AC025541.4, AC051657.2, AC010256.3, AC018539.4, AC026993.2, AC009654.3, AC025060.3, AC026080.2, AC023271.3, AC019312.3, AC026058.2, AC021552.2, AC012571.3, AC025075.2, ACOl 1170.3, AC009699.6, AC021042.3, AC026842.1, AC021914.3, AC013779.3, AC021694.2, AC008418.1 , AC023168.6, AC023000.2, AC013266.3, ACOl 1239.2, AC007373.1, AL136124.8, AL356216.1, AL356055.1, AL137126.4, AL162375.4, AL161640.6, AL160234.1, AP001541.1, AP000945.2, AP000940.2, AP000914.2, AP000614.3, SEQ ID NO.277 NGO-St-128 YS223/T3 5'

D83077.1, D84296.1, D84295.1, D84294.1 , D83327.1 , NM_009441.1, AB008516.1, AJ001866.1, AL163273.2, AP001728.1, AP001429.1, AP000150.1, D83253.1, AP000009.2, AL132992.2, AL132977.1, AC010170.3, U67510.1, X60399.1, D64005.1, AC010643.5, AF210726.1, AE003786.1, AEO03O85.1, AF198444.1, AC006367.3, AF083501.2,

AC006360.2, AC005666.1, AF074613.1, AF043470.1, Z82278.1, AL034408.2, AL049643.12, ABOl 1549.2, AB030387.1, Y11275.1 , AW510696.I , AW130658.1 , AI651380.1 , AI655615.1, AI955031.1, AI365371.1, AW272845.1, AL044710.1, AA733976.1, AI956999.1, N75792.1, AA968229.1, N22573.1, AI935572.1, R49365.1, T65109.1, AA387528.1, AI834826.1, AA226308.1, N45260.1, AW386774.1 , AA226473.1, AI580340.1, AI508671.1, AI462554.1, Fl 1 1 1 1.1, AV373371.1, AV348118.1, AV349801.1, AV348357.1, AW637870.1, AW446918.1, AI662108.1, AI528491.1, AC009801.3, AC026848.2, AF206725.1, AC068145.2, AC068274.2, AC009685.3, AC021196.3, AC012246.3, AC015861.5, AC021000.3, AC022895.2, AC010218.4, AC008680.3, AC008665.3, AC008473.3, AC067842.1, AC048393.1, AC019359.3, AC033746.1, AC025009.2, AC013450.4, AC009746.10, AC018485.6, AC016129.10, AC010667.9, AC023015.2, AL356317.1 , AL355392.2, AL162505.3, ALl 17331.1, AL031011.20,

SEQ ID NO.278

NGO-St-128

YS223 T7 3'

D83077.1, D84296.1, D84295.1, D84294.1 , D83327.1, AL163273.2, AP001728.1, AP001429.1, AP000151.1, D83253.1, AP000009.2, NM_009441.1, AB008516.1, AC007023.3, AL022395.2, AP001432.1, AP000010.2, AC010283.5,

AF224027.1, AC004463.2, U68519.1, AF062065.1, AF062064.1, AF062063.1, AF062062.1, AC007198.6, AF015414.1, AF015413.1, U21135.1, Z81117.1, L21456.1 , L21357.1, L21465.1, L21461.1 , L21458.1, L21452.1, L21448.1, L21446.1 , L21444.1, L21439.1, L21429.1, L21425.1, L21424.1, L21371.1, L21364.1, L21360.1, L21354.1, L21351.1, L24161.1, L21340.1, L21330.1, L21329.1 , L21327.1, AC020717.3, AF224041.1, AC005008.2, AF062041.1, AF062040.1, AF032967.1, AF014360.1, AF014357.1 , AF014290.1 , AF014286.1 , U31582.1, AF015396.1, AF015395.1, AF015394.1, AC005571.1, AC005224.1, AF043433.1, AL022147.3, Z99114.1, U79857.1, AL049832.2, AL132975.1, AJ252870.1, AL132870.2, U32149.1, U32148.1, U53784.1, Z70723.1, D84371.1, AP000383.1, AB007855.1, AI336910.1 , AI337091.1 , AW6651 17.1 , AI885338.1 , AL042620.1 , AA722789.1 , AA743347.1 , AA887657.1 , AI678227.1 , AI318428.1 , AW772752.1, AA515769.1, AW341881.1, AA554904.1, AAl 12857.1, AA083921.1, AW612699.1, AW803145.1, AI568131.1, AL040434.1, AW237011.1 , AI657054.1, AI653679.1, AA470557.1, AA662541.1, AA470510.1 , AA502576.1, AA852823.1 , AW629888.1, R13859.1, AL039361.2, AA021274.1, AW352731.1, AA722688.1, AW488299.1, AA669782.1, H31610.1, AI003122.1, AW525528.1, AA997915.1, AW743421.1, AI646427.1, AI145984.1, W50656.1, AWl 08450.1, AA794421.1, AW466371.1, AW296426.1, AIOl 9132.1 , AA308558.1, H06584.1 , A1666638.1, AA270792.1, AA417656.1, AI838089.1, AI839685.1, AA048256.1, AVI 70771.1, AVI 36593.1, AI846084.1, AI412296.1, Z42452.1 , AV278830.1, AV319373.1, AW822071.1, AV332268.1, AV327734.1, AV259825.1, AV157173.1, AV378262.1, AV341338.1, AW245310.1, AV326279.1, AA155001.1, AI812831.1 , AA386895.1, AAl 14796.1, AA038564.1, AW770946.1 , AW384624.1, AW384613.1, AW384600.1, AW373107.1, AW373096.1, AW373083.1, AW372722.1, AW372709.1, AW372706.1, AW372705.1, AI986424.1, AI968847.1, AI889183.1, AI796812.1, AV142455.1 , AI681420.1, AI681378.1, AI279046.1, R80871.1, R36112.1, AC012032.11, AC012528.2, AL139409.3, AL356276.1, AL139134.4, AL355876.2, AC019259.3, AC025596.1 , AC035146.2, AC025777.3, AC008784.5, AC021573.4, AC068169.1, AC023488.5, AL161450.4, AC069119.1, AC026096.2, ACOl 1669.3, AC021484.3, AC021552.2, ACOl 1853.3, AC019269.3, AL354892.3, AL354715.2,

SEQ ID NO.279 NGO-St-128 YS394 T7 3'

D83077.1, D84296.1, D84295.1, D84294.1, D83327.1, AL163273.2, AP001728.1, AP001429.1, AP000151.1, D83253.1 , AP000009.2, NM_009441.1, AB008516.1, AC007023.3, AL022395.2, AP001432.1, AP000010.2, AC010283.5, AF224027.1, AC004463.2, U68519.1, AF062065.1, AF062064.1, AF062063.1, AF062062.1, AC007198.6, AF015414.1, AF015413.1. U21135.1, Z81117.1, L21456.1 , L21357.1, L21465.1, L21461.1 , L21458.1, L21452.1, L21448.1, L21446.1 , L21444.1, L21439.1 , L21429.1, L21425.1, L21424.1 , L21371.1, L21364.1, L21360.1, L21354.1, L21351.1, L24161.1, L21340.1 , L21330.1, L21329.1, L21327.1, AF224041.1 , AC007955.4, AC005008.2, AF064058.1, AF032967.1, AF014360.1 , AF014357.1 , AF014343.1, AF014290.1, AF014286.1, U31582.1, AC005224.1, AC005304.1, AF020713.1, AF043433.1, AL022147.3, U79857.1, AL049832.2, AL132975.1 , AL132870.2, U53784.1, L28005.1 , Z70723.1 , D84371.1, AI336910.1 , AI337091.1, AW6651 17.1, AI885338.1, AL042620.1, AA722789.1, AA743347.1, AA887657.1, AI318428.1, AI678227.1, AW772752.1 , AA515769.1, AW341881.1, AA554904.1, AAl 12857.1, AA083921.1 , AW803145.1, AI568131.1, AW237011.1, AI657054.1 , AI653679.1 , AW612699.1 , AL040434.1 , AA662541.1, AA470557.1 , AA470510.1, AA502576.1, AA852823.1, AW629888.1 , R13859.1, AA021274.1, AL039361.2, AW352731.1, AA722688.1 , AW488299.1, AA669782.1, H31610.1, AI003122.1, AW525528.1, AA997915.1, AW743421.1 , AI646427.1, AI145984.1, W50656.1, AW108450.1, AA794421.1, AI019132.1 , H06584.1, AI666638.1, AA270792.1, AW466371.1, AW296426.1, AA417656.1, AI838089.1, AA308558.1, AI839685.1, AA048256.1, AV170771.1, AV136593.1, AI846084.1, Z42452.1, AV278830.1, AI412296.1, AV319373.1, AV332268.1, AV327734.1, AV259825.1, AV157173.1 , AV378262.1, AV341338.1, AW245310.1 , AW822071.1, AV326279.1, AW425970.1, AA155001.1 , AI812831.1, AI968847.1, AI889183.1, AV142455.1, AW923586.1 , AW908406.1, AW760328.1, AW349130.1, AW310768.1, AW202374.1, AI957871.1, AI931902.1 , AI790763.1 , AA940042.1 , AA839623.1 , AA739484.1 , AA739481.1 , AA 110637.1 , AC012032.11, AC012528.2, AL139409.3, AL356276.1, AL139134.4, AL355876.2, AC019259.3, AC025596.1, AC035146.2, AC025777.3, AC008784.5, AC021573.4, AC068169.1, AC023488.5, AL161450.4, AC069119.1, AC026469.3, AC021484.3, ACOl 1853.3, AL354715.2, AC037466.3, AC024462.3, AC046167.2, AC046139.4, AC026328.3, AC026307.7, AC023236.8, AC051657.2, AC026709.2, AC026426.2, AC026418.2, AC025289.2, AC018539.4, AC040967.1 , AC023271.3, AC019312.3, AC026058.2, AC012571.3, AC025075.2, ACOl 1170.3, AC026842.1, AC021 178.3, AC021914.3, AC021694.2, AC008801.1 , AC008418.1, AC023388.2, AC021 185.2, AC023502.3, AC013266.3, AC007373.1 , AC002419.1, AL136124.8, AL161640.6, AL162251.3, AL353637.1 , AP001887.1 , AP001362.1, AP000940.2, AP000925.2,

SEQ ID NO.280

NGO-St-129

YS1639/T3 5'

NM_004999.1 , AB002387.1, U90236.1, Z35331.1 , NM_008662.1, U49739.1, AF017303.1, AL096862.18, AF146793.2, AE003650.1, AE003436.1 , AE003415.1, AL161595.2, AL078620.2, AL023494.12, AL096821.2, NC_001146.1 , AC020912.4, AE003764.1, AC002524.1, AF221108.1, NM_012415.1 , AFl 12481.1, AFl 18397.1, AC006236.1, AF084206.1, AL009050.9, AL032632.1, AL109759.3, AJ251914.1, X13464.1, X03975.1, Z71468.1, M14045.1 , D37977.1 , AW629832.1 , AA129385.1, AA028987.1, AA577227.1, AW300529.1, AW316711.1 , AI863551.1, AI829419.1, AI366126.1, AI310303.1, AA910369.1, AA523580.1, AA522566.1, AI698448.1, AW235712.1, AA889126.1 , AW741450.1, AW663829.1, AI747845.1, AW660315.1, AI093634.I, AA790620.1, AW696022.1 , A W601223.1,

AI413054.1, AA037700.1, AW831515.1, AJ392575.1 , AI820852.1, AI820850.1, AI792698.1, AI792696.1 , AI466405.1, AI252501.1, AI252429.1, AA880900.1, AA696342.1, C80997.1, C70576.1, AA542732.1, AL136093.4, AC016868.4, AC021058.7, AC036192.2, AC007365.2, AC061984.2, AC018880.2, AC021861.3, AC018545.4, AC062006.2, ACOl 1374.4, ACOl 1406.2, AC009544.4, AC026565.2, AC016859.2, AC017680.1, AC014098.1, AC007515.1 , AL096873.2, AP001924.1, AP001384.1, AP001359.1, APOOl 163.1, AP000674.1, AP000666.1, AC069305.1, AC024019.3, AC022898.4, AC024035.3, AC009511.12, AC027644.4, AC007780.2, AC020897.5, AC067776.1, AC058782.1 , AC018508.4, AC019309.3, AC025687.2, AC020989.5, AC013547.2, AC021008.1, AC020767.1 , ACOl 8878.1, AC013527.2, AC015353.1, AC012474.1, AL355972.3, AL139002.4, AL121828.8, AL139814.5, AL355312.3, AL354743.1, AL162852.3, APOOl 167.1, AP000942.2,

SEQ ID NO.281

NGO-St-129

YS1639/T7 3'

NM_004999.1, AB002387.1, AC0001 17.1, AC006050.1 , AEOOl 131.1, AC005494.1, AC003068.1, AL161585.2, AL035521.1, AL163227.2, AC000374.1 , Z98748.1 , APOOl 115.1, AC005529.7, AC005617.2, AF172282.1, AC000025.2, AC004539.1, AC003080.1, AF058919.2, AC008261.3, AC004682.1, AE001579.1, AC005527.3, AC002991.1, AC003682.1, L06196.1, AF036692.1 , AL161545.2, AL161472.2, Z99281.1, Z97342.2, AL022393.1, AL035661.16, AL109837.21, Z35331.1, AW772270.1, AI971254.1, AW242758.1, AW772647.1, AW168128.1, AA129322.1, AW450254.1, AI208776.1 , AW613386.1, AW172995.1, AW513273.1, AW073777.1, AI921929.1, AW452837.1, AW450587.1, AI91 1506.1, AA625890.1, AI925526.1, AI991532.1, AW473956.1 , AAl 66906.1, AI318048.1,

AW448948.1, AI304536.1, AW451044.1, AW451217.1, AA429372.1 , AI061190.1, N63006.1, AW614329.1, N39073.1, AI357971.1, AW449081.1 , N49974.1, H15162.1, AA493764.1 , AA632762.1, AA503650.1, AW072577.1, H88721.1 , H88672.1 , N62772.1 , R37296.1 , AA365146.1 , AA492569.1 , W01757.1 , D62451.1 , AA482738.1 , N52751.1, AI373764.1 , AA235474.1, AI631867.1, AI740513.1 , AA330423.1, AW169179.1, AW195663.1, AI537958.1, AI767492.1, AI654090.1, AA620412.1, AA861190.1 , AI659277.1, AA025688.1, AI375865.1, AI928490.1, AI651240.1 , AA846667.1, AA161244.1, AA136973.1, AAl 14997.1, AW594496.1, AW573252.1, AV305797.1 , AW149932.1, AV221167.1, AW085043.1, AW048157.1, AI871868.1, AI870057.1, AI859823.1, AI689778.1, AI678876.1, AI678873.1, AI669925.1, AV024912.1, AI550341.1, AI537625.1, AI350956.1, AI278232.1, AI187925.1, AI160733.1, AA822328.1, AA742262.1, AA422443.1 , AA217420.1, AL136093.4, AC068777.3, AC063951.3, AC026784.2, AC024037.2, AL021152.1, AC055882.3, AC024304.3, AC013756.3, AC026221.3, AC020732.3, AC025666.2, AC025801.2, AC021466.2, AC018666.4, ACOl 1840.3, AC013411.2, AC015783.2, AC002317.1, ALl 18519.20, AL161736.5, AL139215.4, AL033520.15, AL354827.1, AL354815.1, AP000915.2, SEQ ID N0.282 NGO-St-129 YS1772/T3 5'

U90236.1 , Z35331.1, NM_004999.1 , AB002387.1 , NM_008662.1 , U49739.1 , AF017303.1 , AL096862.18, AE003650.1 , AE003436.1, AE003415.1, AL161595.2, AL078620.2, NC .001146.1, AE003764.1 , ACOl 8833.3, AF221108.1, AJ251914.1, X13464.1 , X03975.1, Z71468.1, M14045.1, D37977.1, X78287.1, X78286.1, AW629832. l, AA129385.1, AA577227.1, AA028987.1, AW300529.1, AA889126.1, AA037700.1, AI093634.1, AA790620.1, AW660315.1, AW449252.1, AI747845.1, AW741450.1, AI413054.1, AW831515.1, AW663829.1, AW594845.1, AJ392575.1, AW316711.1, AW235712.1, AI863551.1, AI829419.1, AI698448.1, AI366126.1, AI310303.1, AA910369.1, AA696342.1, AA542732.1 , AA523580.1, AA522566.1, AL136093.4, AC021058.7, AC061984.2, AC018880.2, AC021861.3, AC017680.1, AC014098.1, AC008577.4, AC009070.5, AC058782.1 , AC032032.1 , AC025687.2, AC012269.2, AC026206.1 , AC013547.2, AC022011.2, AC018835.3, AC023575.2, AC022381.1, AC018878.1, AC013398.2, AC013527.2, AC015353.1, AL355972.3, AL139002.4, AL139814.5, AL354743.1, AL162852.3, AP001087.2, AP001272.1,

SEQ ID NO. 283 NGO-St-129 YS1772/T7 3'

NM_004999.1, AB002387.1, AL161585.2, AL035521.1, AC018833.3, AL161536.2, AL049608.1, AL078604.10, U60176.1, AC005494.1, AC000374.1, Z98748.1, AC003080.1, AC007390.3, AC004069.1, AF036692.1, Z68227.1, AW772270.1 , AI971254.1, AW772647.1, AW242758.1, AA129322.1, AW168128.1, AW450254.1, AI208776.1, AW613386.1, AW513273.1, AI921929.1, AW073777.1, AW172995.1, AW452837.1, AW450587.1, AI911506.1, AA625890.1, AI925526.1, AAl 66906.1, AI991532.1, AW473956.1, AW448948.1, AI304536.1, AI318048.1, AW451044.1, AW451217.1, N63006.1, AA429372.1, N39073.1, N49974.1, AI061190.1, H15162.1, AW614329.1, AW449081.1, AI357971.1 , AA632762.1 , AA493764.1 , H88672.1 , AA503650.1 , H88721.1 , R37296.1 , AA365146.1 , AW072577.1, N62772.1, W01757.1, AA492569.1, D62451.1, AA482738.1, AI373764.1, AA235474.1, N52751.1, AI631867.1, AI740513.1 , AA330423.1, AW169179.1, AW195663.1, AI537958.1, AI767492.1, AI654090.1, AA620412.1, AA861190.1, AI659277.1, AA822328.1, AI790656.1, AI52881 1.1, AA718487.1, AA070821.1, AI013854.1, AA025688.1, AI006104.1, AA087822.1, AI153153.1 , AW573252.1 , AW151 175.1 , AW085043.1, AW073863.1, AI700842.1 , AI501875.1 , AI187925.1, AI160733.1, AI026889.1, AA907037.1, AA120798.1, AL136093.4, AC020732.3, AL161450.4, AC068777.3, AC063951.3, AC022918.2, AL136990.14, AC024086.3, AC037486.2, AC025666.2, AC013411.2, AL354827.1 , AP001448.1, AC021 173.3, AC026702.3, AC009095.5, AC015707.3, AC026526.2, AC024476.2, AC013727.3,

SEQ ID NO. 284 NGO-St-129 YS1781/T7 3'

NM_004999.1, AB002387.1, AL161585.2, AL035521.1, AC018833.3, AL049608.1 , AL078604.10, AF077341.1, AF132734.1 , AC006050.1, AEOOl 131.1, U60176.1, AC005494.1, AC003068.1, AC000374.1, Z72521.1, Z98748.I , APOOl 115.1, AC005617.2, AC003080.1, AC004069.1, AF036692.1 , Z68227.1 , AI971254.1 , AW772270.1 , AW242758.1 , AW772647.1, AA129322.1, AW168128.1, AW450254.1, AI208776.1, AW613386.1 , AW513273.1, AI921929.1 , AW073777.1 , AW172995.1, AW452837.1, AW450587.1, AI91 1506.1, AA625890.1, AI925526.1, AA166906.1,

AI991532.1 , AW473956.1 , AW448948.1 , AI304536.1 , AI318048.1 , AW451044.1 , AW451217.1 , N63006.1 , AA429372.1 , N39073.1, N49974.1, AI061190.1, H15162.1, AW614329.1, AW449081.1, AI357971.1, AA632762.1, AA493764.1 , H88672.1, AA503650.1, H88721.1, W01757.1 , R37296.1, AA365146.1, AW072577.1, N62772.1, AA492569.1, D62451.1, AA482738.1 , AI373764.1 , N52751.1, AA235474.1 , AI631867.1 , AI740513.1 , A A330423.1 , AWl 69179.1 , AWl 95663.1 , AI537958.1, AI767492.1 , AI654090.1, AA620412.1, AA861190.1, AI659277.1, AA822328.1, AI790656.1, AI52881 1.1, AA718487.1, AA070821.1, AI013854.1, AA025688.1, AI375865.1, AI181759.1, AI006104.1, AA087822.1, AI153153.1, AI501875.1, AL136093.4, AC020732.3, AC022938.3, AC068777.3, AC063951.3, AC026784.2, AC018914.3, AC022918.2, AL136990.14, AL356054.2, AL354827.1, AC013401.2, AC026702.3, AC015707.3, AC024673.2, AC026526.2, AC024476.2, AC013727.3, AL109660.3,

SEQ ID NO. 285

NGO-St-130

YSU 1/T3 5'

NM_001981.1, U07707.1, Z29064.1 , NM_007943.1 , L21768.1, L14298.1, AC008269.3, AF229843.1, AC004527.2, AC006557.2, AL162295.1, AL163259.2, AL163205.2, AP001714.1 , AP001660.1, AP001634.1, AP000180.1, AP000272.1, AP000104.1, AC005824.2, AE003551.1, AF173983.1, AC002449.1, AF091848.1, AF067807.1, U24215.1 , AL133376.6, AL033521.2, X56494.1, D21071.1, AL041882.1, C17654.1, AW368006.1, AA140007.1, AI557588.1, AA349569.1 , AA839181.1, AW891551.1, AU079083.1, AV105710.1, AV041867.2, AV011556.1 , AV010206.1, A V441258.1, AW562154.1, AW288397.1, AW221715.1, AV383554.1 , AL043683.1, AL043682.1, AI774525.1, AI486675.1, AA907496.1, AA72851 1.1, AA570698.1, AA041001.1, R65462.1, Z34628.1, AC048367.2, AL138904.2, AL354990.1, AC068561.1 , AC065048.1, AC062150.1, AC058723.1, AC035761.1, AC024413.3, AC012403.5, AC016964.5, AC022169.2, AC024287.3, AC027418.2, AC016498.4, AC024433.2, AL356266.3, AL157813.3, AL354698.2, AP001004.2, APOOl 130.1, AC009179.15, AC009386.6, AC024905.7, AC023600.13, AC024523.2, AC025446.3, ACOl 1537.6, AC036127.2, AC067715.1, AC066596.1, AC040168.1, AC020779.3, AC018827.4, AC009659.3, AC016890.4, AC022475.2, ACOl 1266.3, AC022978.3, AC016853.4, AC007495.3, AC010043.4, ACOl 8976.2, AC022048.1, AC020151.1, AL161660.6, AL133318.4, ALl 37779.1 , AP0OO895.2, AP001578.1 ,

SEQ ID N0.286 NGO-St-130 YS111/T7 3'

NM_001981.1, AF052132.1 , Z29064.1 , U07707.1 , AF 119858.1 , AC007504.3, AF235098.1 , AF 191069.1 , AC003092.1 , AF096876.1, AL163252.2, ALl 15814.1, AP001707.1, AC007376.8, AL021811.1, Z69729.1, AC002113.1 , AL031767.13, M22886.1, AC010143.3, AC010971.3, AF002223.1, AF063866.1, AC003665.1, AC005808.1, AL035079.14, AL163232.2, X71844.1 , APOO 1687.1 , AP000459.3, AL043535.1 , AA781358.1 , AI692447.1 , N32153.1 , AI453034.1 , AI813894.1 ,

AAl 15267.1, AI288222.1. N25318.1, AA534309.1, AA115291.1, AI718641.1, AI978915.1, AI208237.1, AW169456.1 , AI275885.1, AW769406.1, AI693511.1 , AA886343.1, AA150461.1, N49086.1, AA825660.1, AW075886.1, AA813360.1, AW614630.1 , AI520942.1, AA534862.1, Z44586.1, AA164418.1, AA702296.1, AA485200.1 , N66885.1 , AI920898.1, AW087764.1, N78949.1, R68155.1 , N25787.1 , A W813048.1, R62156.1, T10010.1, AA478744.1, AI810955.1 , F10989.1, AA748186.1 , T28758.1, H13536.1, AA644498.1, AW769677.1, AI472645.1, AA385221.1, AI472603.1 , AW188171.1, W17317.1, H13535.1, AA585349.1, R59914.1 , AA300847.1, AA251517.1, F03176.1, AW050401.1, AA485087.1, AI267611.1, AW366454.1 , T25018.1 , D 19928.1 , Z46052.1 , AA251530.1 , R63487.1 , X85627.1 , AI060900.1 , AA833154.1 , AAl 19303.1, AV361642.1, C80702.1, AV251200.1, AW053510.1, AA630896.1 , W02559.1 , N48143.1, N38997.1, AW8O4902.1, AW776207.1, AW775801.1, AW362615.1, AV368479.1, AI452571.1, AI309292.1 , AA845594.1, AA505330.1, AA287832.1, AA287578.1 , D48726.1, AC048367.2, AC055751.2, AC020941.3, AC017093.2, AC025170.3, AC008488.6, AC019332.3, AC026475.3, AC068066.1, AC015876.3, ACOl 1112.3, AC018392.3, AL354712.2, AL354760.1, AC048389.3, AC068130.2, AC024164.2, AC004898.2, AC027226.2, AC058798.1, ACOl 1152.4, AC010104.2, AL139125.3, AL133282.13, AL035554.1, AP001590.1, SEQ ID N0.287 NGO-St-130 YS383/T3 5'

NM_001981.1, U07707.1, Z29064.1 , NM_007943.1, L21768.1, NM_002396.1, Z95117.1, AP002054.1, U00021.1, M55905.1, AE003677.1, NM_007944.1, AC004862.1 , AFl 1 1169.2, AC007543.4, AF131768.1, AC005758.1, AC004476.1, Z35601.1, AL133299.2, AL096802.1 1, U29156.1, AB027020.1, AI936583.1, AA837424.1, AW340591.1, AA832056.1,

AI663323.1, AA642291.1, AL043493.1, AI151900.1 , AA637559.1, AA877097.1, AA140007.1, AI584949.1, AW503469.1, AI979367.1, AW372581.1, AU051615.1, AA625121.1, AA490194.1, AA442710.1, AA229914.1 , AA229604.1, T70290.1, AW765795.1, AV406101.1, AW186947.1, AI324049.1, C44114.1, R54352.1, R52338.1 , F06891.1, F05583.1, T34448.1, Z43889.1, AL138904.2, AL354990.1, AC026989.2, AC026390.1, AC022373.1, AL157785.3, AL162716.4, AL355332.1, AC040919.1, AC046143.3, AC009078.4, AC021477.3, AL136170.3, AL139022.1, AP001845.1, AC037471.3, AC024404.3, AC046166.2, AC012212.4, AC067723.2, AC024891.8, AC025243.3, AC005883.9, AC068054.2, AC068389.1, AC026821.2, AC021585.3, AC023102.2, AC025339.1, AC016044.4, AC008094.4, AC021901.2, AC021342.2, AC022837.1, AC020679.2, AC014595.1, AL136121.5, AL356133.2, AL355176.1, AP001542.1, AL008872.1,

SEQ ID NO.288

NGO-St-130

YS383/T7 3'

NM_001981.1 , AF052132.1 , Z29064.1, U07707.1, AFl 19858.1, AC007504.3, AF235098.1 , AF191069.1 , AC003092.1, AF096876.1, AL163252.2, ALl 15814.1, AP001707.1, AC007376.8, AL021811.1, Z69729.1, AC0021 13.1, AL031767.13, M22886.1, AC010143.3, AC010971.3, AC002479.1 , AF002223.1, AF063866.1, AC003665.1, AC005808.1, AL035079.14, AL163232.2, AL035458.35, X71844.1, AP001687.1, AP000459.3, AL043535.1, AA781358.1, AI692447.1 , N32153.1, AI453034.1. AI813894.1, AAl 15267.1, AI288222.1. N25318.1, AA534309.1, AAl 15291.1, AI718641.1, AI978915.1, AI208237.1, AW169456.1, AI275885.1, AW769406.1, AI693511.1, AA886343.1, AA150461.1, N49086.1, AA825660.1, AW075886.1 , AA813360.1, AW614630.1, AI520942.1, AA534862.1, Z44586.1, AA164418.1, AA702296.1, AI920898.1, AA485200.1, N66885.1, AW087764.1, N78949.1, R68155.1, N25787.1, R62156.1, T10010.1, AA478744.1 , AI810955.1, F10989.1, AA748186.1, T28758.1, H13536.1, AA644498.1 , AW769677.1, AI472645.1, AA385221.1, AI472603.1, R59914.1, AA585349.1, AA300847.1 , AA251517.1 , AA485087.1, AW050401.1, F03176.1, AI26761 1.1, AW188171.1, W17317.1, H13535.1, AW813048.1, AW366454.1, T25018.1, D19928.1, AA251530.1, X85627.1, AI060900.1, AA833154.1, AAl 19303.1, AV361642.1, C80702.1, AV251200.1 , AW053510.1, AA630896.1 , W02559.1. N48143.1,

N38997.1, AW776207.1, AW775801.1 , AW362615.1, AV368479.1, AW154919.1, AI868315.1, AI452571.1, AI401460.1, AA845594.1, AA550576.1, AA505330.1, AA287832.1, AA287578.1, AC048367.2, AC020941.3, AC017093.2, AC025170.3, AC008488.6, AC008948.5, AC019332.3, AC026475.3, AC015876.3, ACOl 1112.3, AC018392.3, AL354712.2, AL354760.1, AC068130.2, AC024164.2, AC004898.2, AC027226.2, ACOl 1152.4, AC010104.2, AL139125.3, AL133282.13, AP000793.1,

SEQ ID NO.289 NGO-St-131 YS161/T3 5'

AB002318.1 , NM_01 1602.1, X56123.1, AF177198.1 , NM_006289.1, AF078828.1, AB028950.1, AF178534.1 , AC009044.3, AE003535.1 , AF224669.1, U41384.1 , X59601.1, Z66108.1, Z66107.1, NM_016559.1, AC020610.6, AE003745.1, AC002044.1 , NM_011027.1, AC005145.1, AC005544.1, U51243.1, AL080195.1, AL021918.1 , AB032593.1, AB032592.1 , Z57921.1, AJ009823.1 , AI751285.1 , AW900719.1 , AA452483.1 , AA387755.1 , AW336094.1 , Wl 7774.1 , AA4741 15.1, AA718262.1, AI593159.1, AA657201.1, AA615519.1, AI331130.1, R17242.1, AW437322.1, AW654277.1, AW336729.1 , AA015516.1, AA013971.1, R54389.1, AW640826.1 , AW403043.1, AL042809.1, AL047970.1, AI343291.1, D31413.1, T27372.1, T06850.1, AI691500.1, AW137249.1, AI980726.1, AI387487.1, AA748793.1, AA737559.1, AC026030.2, AC068233.1 , AL133410.1 1, AC009122.5, ACOl 1056.3, AC024491.4, AC009696.5, AC018797.3, AC026049.2, AC024629.1, AC015146.1, AP002018.1,

SEQ ID NO.290

NGO-St-131

YS161/T7 3'

AB002318.1, AF085910.1, AL137080.2, NM_016761.1, AC005825.3, AF221104.1, AF221103.1 , AF221102.1 , AF 1 10520.1 , AC003958.1, AL031276.1 , AL008627.1 , D49544.1 , AI823644.1 , AW629480.1 , AI751284.1, AA290619.1, AA290618.1, AW136798.1, AW195082.1, AI566119.1, AI866810.1, AI307663.1, AI417845.1, AW242353.1, AI479172.1, AI31 1003.1, AI522054.1, AI952372.1, R99633.1, AI249792.1, AI366767.1, AW469603.1, AA854194.1, AA582699.1, AI380822.1, AW303332.1, R99089.1, AW902895.1, AW136171.1, AW902834.1, AI985231.1, T16297.1 , AI985222.1, T17377.1, AA291006.1, T32600.1, AA291005.1, AW902806.1, AI142264. I, W22495.1, T20064.1, AW898163.1, AW251506.1, AA998450.1, AI072764.1, AI851526.1, AI787438.1, AI465290.1, AA967834.1, AA718676.1, AA039087.1, AA511363.1 , AV252009.1 , AV272145.1 , D80367.1 , D80366.1 , D80352.1 , D80351.1, D80339.1 , D80331.1, D80330.1 , D80314.1, D80261.1, D80254.1, D80253.1, D80252.1, D80251.1, D59773.1, D59717.1, AI705776.1, AV175623.1, D80293.1, D59809.1, AV249990.1, AW488444.1, AW389528.1, AW218598.1, AI507221.1, C85503.1, AA709996.1, W83532.1, AC026030.2, AC016814.4, AC022910.2,

SEQ ID NO.291

NGO-St-131

YS101/T3 5'

AB002318.1, NM_01 1602.1, X56123.1, AF177198.1, NM_006289.1, AF078828.1, AB028950.1, AF065739.1, AF178534.1 , AC005145.1, AC009044.3, AF224669.1, U41384.1, X59601.1, Z66108.1, Z66107.1, NM_016559.1,

AC020610.6, NM_01 1027.1, AC005544.1, U51243.1, AL080195.1, AL021918.1, AB032593.1, AB032592.1, Z57921.1, AJ009823.1 , AI751285.1, AW900719.1 , AA452483.1 , AA387755.1, AW336094.1, W17774.1 , AA474115.1, AA718262.1, AI593159.1, AA657201.1, AA615519.1, AI331130.1, AW437322.1, R17242.1, AW654277.1, AW336729.1, R54389.1, AW640826.1, AA015516.1, AA013971.1, T06850.1, AW403043.1 , AL042809.1, AL047970.1, AI343291.1 , D31413.1 , T27372.1, AW137249.1, AI980726.1, AA748793.1, AA737559.1, AC026030.2, AC068233.1, AC009122.5, AL133410.1 1 , AC024491.4, AC009696.5, AC018797.3, AC026049.2, AC024629.1, AP002018.1, AC026959.3, AC025148.3, AC007653.4, AC012337.3, AC009772.4, AC021650.9, ACOl 1827.3, AC064839.3, AC010074.6, AC013614.4, AC013733.3, AC013405.1, AC021095.1, AC020569.1, AC008076.8, AL355819.2, ALl 17336.18, AP001007.1, SEQ ID N0.292 NGO-St-131 YS101/T7 3')

AB002318.1, AF085910.1, AF011399.1, AF011398.1, AL137080.2, NM_016761.1 , AC005825.3, AF221104.1, AF221103.1, AF221102.1, AFl 10520.1, AC003958.1, AL031276.1, AL157416.1, AL138642.1, AL008627.1, D49544.1, AI823644.1 , AW629480.1, AI751284.1, AA290619.1 , AA290618.1 , AW136798.1, AW195082.1, AI566119.1,

AI866810.1, AI307663.1, AI417845.1, AW242353.1, AI479172.1, AI31 1003.1, AI522054.1, AI952372.1, R99633.1, AI249792.1, AI366767.1, AW469603.1, AA854194.1, AA582699.1, AW303332.1, R99089.1, AW136171.1, AI380822.1, AW902895.1, AW902834.1 , AI985231.1, T16297.1, AI985222.1, T17377.1, AA291006.1 , T32600.1, AA291005.1, AW902806.1 , AI142264.1, AW898163.1 , W22495.1, T20064.1, AW251506.1, AA998450.1, AI072764.1, AA718676.1, AI851526.1, AI787438.1, AI465290.1, AA967834.1, AA039087.1, AA51 1363.1, AV252009.1 , AV272145.1, AI705776.1, D80367.1 , D80366.1 , D80352.1 , D80351.1, D80339.1 , D80331.1, D80330.1 , D80314.1 , D80261.1 , D80254.1 , D80253.1 , D80252.1, D80251.1, D59773.1, D59717.1, D80293.1, D59809.1 , AV175623.1, AV249990.1, AA370498.1 , AW488444.1, AW389528.1, AW218598.1, AI507221.1, AA960722.1, AA960721.1 , C85503.1, AA709996.1 , W83532.1, L38220.1, AC026030.2, AC016814.4, AC022910.2,

SEQ ID N0.293

NGO-St-132

YS011 T3 5'

NM_000346.1, AC007461.8, S74506.1, Z46629.1 , AF029696.1 , AF006571.1 , U12533.1, AB012236.1 , AB035888.1, AB035887.1, AF106572.1, AB006448.1, D83256.1, NM_006941.1, AF006501.4, AL031587.3, AJ001183.1, AF191325.1, AF164104.1, AF226675.1, Z99757.12, AF047389.1, AF047043.1, AF017182.1, U66141.1, U66105.1, AJ001029.1, AE002049.1, AL135162.1, AW701461.1, AW323770.1, AW232285.1, AA220077.1, T18789.1, AW924151.1, AW747248.1, AW746893.1, AW746873.1, AW746213.1, AW681012.1, AW680640.1, AW677948.1, AW677800.1, AW672276.1, AW672019.1, AW665912.1, AW471059.1, AW384568.1, AW384558.1, AW384516.1, A W384461.1, AW371943.1, AW286733.2, AW406345.1, AW321606.1, AW298118.1, AW290875.1, AW289095.1, AW245072.1, AW161855.1, AW161352.1, AW103014.1, AW007471.1, AI885013.1, AL035821.1, AI682325.1, AI539787.1, AI497991.1, AI410380.1, AI351117.1, AI350368.1, AI338712.1, AI335760.1, AI286186.1, AI266340.1, AI186949.1, AI167245.1, AI144319.1, AI134312.1, AI062232.1, AA973886.1, AA906673.1, AA904015.1, AA873306.1, AA836977.1, AA688139.1, AA634800.1, AA630304.1, AA592961.1, AA472666.1, AA449553.1, AA449122.1, AA443810.1, AA314988.1, AA287892.1, AA243383.1, W57682.1, T49849.1, AC040983.1, AC009041.5, AC012004.3,

SEQ ID NO.294 NGO-St-132 YS1637 T3 5'

NM_000346.1, Z46629.1, AF029696.1, AB012236.1, U12533.1, AC007461.8, S74505.1, AF106572.1, AF265207.1, AF061784.1, NM_006941.1, AJ001183.1, S74504.1, AB035887.1, AF226675.1, AF006501.4, AL031587.3, S74506.1, U66141.1, AJ001029.1, AF047389.1, AF047043.1, AF017182.1, AF006571.1, Z18958.1, X79250.1, AF164104.1, AB035888.1, Z99757.12, AF152356.2, AJ245601.1, AB006448.1, AF191325.1, Z18957.1, Z18959.1, D83256.1, U70441.1, NM_011441.1, D49474.1, D49473.1, L29085.1, NM_005986.1, AX001335.1, Y13436.1, NM_007084.1, AF107044.1, AB033888.1, X65664.1, U31967.1, NM_011443.1, NM_009233.1, NM_009234.1, AF009414.1, AX001334.1, AX001333.1, X96997.1, X94127.1, X94126.1, ABOl 1802.1, L29086.1, NM_003107.1, NM_009236.1, L35032.1, X70683.1, AFl 16571.1, NM_009238.1, NM_005686.1, AF098915.1, X70298.1, Z31560.1, ABO 14474.1, L07335.1, S69429.1, NM_006942.1, AC007421.12, U12532.1, D50603.1, AB006867.1, AF193760.2, L12010.1, AJ004858.1, M86315.1, AB026622.1, AE003776.1, AJ251580.1, AJ001730.1, NM_011446.1, NM_009237.1, U12467.1, X94125.1, AB023419.1, ABOl 1803.1, M86335.1, X73038.1, AF001047.1, L12022.1, L12020.1, X65660.1, L12013.1, M86313.1, AI594348.1, AA616534.1, AL120408.1, AW321606.1, AW153579.1, AW184648.1, AVI 16901.1, AW343046.1, AV120409.1, AW231213.1, AW227743.1, AW210917.1, AW513608.1, AW152310.1, AI935610.1, AI821650.1, AI758881.1, AI743736.1, AI743707.1, AI739667.1, AI732705.1, AI635063.1, AI073502.1, AA260278.1, AI765094.1, AI087935.1, AW048216.1, AA434433.1, AA427400.1, AA405793.1, AW434258.1, AW045442.1,

AI574719.1, All 37262.1, All 36910.1, AA799800.1, AA959594.1, AI009328.1, AA411418.1, AW533591.1, AW533022.1, AW532784.1 , AW526351.1 , AI716553.1 , AI029515.1, AI029109.1 , AA956282.1 , AA956131.1, AA924900.1 , AA924896.1, AA875101.1, AI145897.1, AI136894.1, AI112078.1, AI102567.1, AA943207.1, AW244680.1, AI828016.I, AI817673.1, AI240186.1, AW766057.1, AW615144.1, AW532037.1, AW414006.1, AW235281.1, AW131791.1, AW131705.1, AW071909.1, AW055151.1, AW044044.1, AW028031.1, AW005368.1, AI990431.1, AI971611.1,

AI631443.1. AI611652.1, AI571299.1, AI566261.1, AI480221.1, AI423139.1, AI421743.1, AI421119.1, AI418146.1, AI373018.1, AI364349.1, AI356682.1, AI327463.1, AI292258.1, AI199308.1, AI151028.1, AH 46406.1, AH 46367.1, AI137787.1, AI097136.1, AI096977.1, AI094794.1, AI056908.1, AI052267.1, AI717565.1, AA405899.1, AC009041.5, AC012004.3, AF215846.1, AL355803.2, AL137061.2, AL136179.11, ALl 17346.16, AC024914.17, AC020788.4, AC015652.6, AC008220.4, AC007975.6, AC008318.6, AC012822.1, AC020509.1, AC055113.1, AL137016.10, AC024915.10, AC058787.7, AC024069.15, AC007588.3, AC017264.1, AL121747.21, AC068951.1, AC011649.3, AC026244.2, AC021051.3, AC027243.2, AC040983.1, AC027700.1, AL162584.3, AC022980.3, AC016156.7, AC068986.3, AC022499.5, AC026376.7, ACOl 1544.5, AC008569.5, AC021881.2, AC022532.2, AC022917.3, AC023096.1, AC022606.2, AC005528.25, AC010665.4, AC010575.3, AC023011.1, AC010892.3, AC019870.1, AC013906.1, AC014152.1, AC014782.1, AC009485.2, AL139246.4, AL034405.13, AL159992.3,

SEQ ID NO.295 NGO-St-132 YS1637/T73' NM_000346.1, AC007461.8, S74506.1, Z46629.1, AF029696.1, AC007070.4, U61951.2, AB023041.1, AB006448.1, AC022521.4, AC007196.4, AC005169.2, AE003780.1, AC012392.1, AF162444.1, AC006240.1, AL161548.2, AL161502.2, NC_001142.1, ACO04669.2, AC004411.2, AC002329.2, AC018363.6, AC008134.3, AC007259.4, AC005508.1, AC004562.1, AF058914.1, AC002539.1, AL163814.1, AL163812.1, AL161561.2, AL049655.2, AL049171.1, AL022023.1, AL021637.2, Z35596.1, AL078637.1, AL132960.2, AL132970.2, AL132965.1, AL049538.8, U39674.1, AP001313.1, Z20656.1, AP000367.1, AP000371.1, AW005563.1, AA576678.1, AI934455.1, AI382146.1,

AA527295.1, AI870355.1, AI380233.1, AI681309.1, AI299871.1, AA913619.1, AW087477.1, AA912521.1, AA778589.1, AI453423.1, AW360836.1, AA331097.1, H90100.1, AA469143.1, AA420856.1, AW075227.1, AA884178.1, AA420456.1, AA657762.1, AI348085.1, AA333065.1, AW888412.1, AW142661.1, AI985948.1, AA400739.1, AA955408.1, AI008321.1, AW213674.1, AI852411.1, AI548994.1, W24710.1, AW360293.1, AW323128.1, AV021074.1, AW897800.1, AI599999.1, AV281945.1, A V220920.1, AVI 44700.1, AV008800.1, AV233902.1, AA469215.1, AV360627.1, AV 165338.1, AV220098.1, BB004489.1, AV349732.1, AV302326.1, AW228243.1, AW360802.1, AI504553.1, AV280305.1, BB003834.1, AV305178.1, C15879.1, AV163514.1, AW381053.1, AV305177.1, AV318841.1, AW829173.1, AV361282.1, AV248007.1, R30640.1, AW900425.1, AW892801.1, AW776398.1, AW697226.1, AW690623.1, AW586197.1, AW586064.1, AW559610.1, AW267726.1, AW218488.1, AU061986.1, AH 64072.1, AI 162251.1, AA825782.1 , AA41 1689.1 , H63328.1 , T48235.1 , AV424751.1 , ACO 13323.5, AC007194.1 , AC025309.2, AC006755.1, AC024521.3, AC013645.3, ACOl 1065.4, AC024527.3, AC010190.7, AC024104.4, ACOl 1491.4, AC026623.2, AC021142.4, AC034285.1, AC025724.1, AC015854.3, AC021507.2, AC008258.3, AL078597.4, ALl 63642.1. AL021576.1,

SEQ ID N0.296

NGO-St-133

YS102/T3 5'

NM_014820.1, AB018262.1, Z19158.1, AP000007.I, AF102137.1, Z80789.1, AB030817.1, L1433I.1, AC006840.17, AC004606.1, AL031012.1, AP001425.1, AB025414.1, AC016752.2, AE003801.1, AE003726.1, AE003616.1, AE003485.1, AE003420.1, AF127577.2, AC015450.3, AC008040.7, AC006596.2, AC006050.1, AL035331.1, AL078611.1, AL163243.2, Z71182.1, AP001698.1, Z79997.1, AP000208.1, AP000247.1, AP000130.1, AW468485.1, W76094.1, AA449405.1, AW230655.1, AA313460.1, AI325788.1, AI892481.1, AAl 16789.1, AA076346.1, AA373986.1, AV145606.1, AW227769.1, AW320879.1, AI535287.1, Z19251.1, AW765531.1, AW281101.1, AA985348.1, AW656932.1, AW481973.1, AW410280.1, AW356980.1, AW336895.1, AW200321.1, AW050865.1, AI834977.1, AL048825.1 , AI646136.1 , AI478830.1 , AA345311.1, AA278482.1 , AA203592.1 , Rl 0075.1 , T99341.1 , T81329.1 , AC015462.5, AC023782.2, AC025607.3, AC018351.8, AC068119.1, AC026858.2, AC016229.3, AC012437.3, AL138879.3, AP001901.1, AC036213.3, AC010464.4, AC026644.2, ACOl 1615.3, AC008293.1, AL354734.3, AL353707.1, AL162311.1, AL157757.1, AC012413.4, AC023891.7, AC026770.3, ACOl 1960.3, AC027067.2, AC015595.3, AC017094.5, AC007521.i l, AC015996.2, AC012972.1, AL157905.3, AL354800.3,

SEQ ID N0.297 NGO-St-133 YS102/T73' NM H4820.1, AB018262.1, AF010516.1, AC005406.2, Z70268.1, AC009044.3, AE003547.1, NM_006021.1, Z74035.1, X95549.1, AL022722.1, AL109925.11, AJ243368.2, Z70688.1, Y 15228.1, AP000382.1, AE003736.1, AL049612.11, AI769448.1, AI581514.1, AW471382.1, AI671783.1, AW044465.1, AI795924.1, AW009918.1, AWl 67186.1, AI278004.1, N49863.1, AW083882.1, AI283007.1, AI833063.1, AI478170.1, AI078346.1, AA707693.1, AI770160.1, AI126207.1, AW513624.1, N59383.1, HI 1342.1, AI679546.1, D60203.1, AW102995.1, AA047406.1 , N67748.1 , AI373915.1, AA937689.1, AA535637.1, AW770695.1, AA088722.1, AI278065.1, AW470297.1, AI984753.1, AI281086.1, AI088753.1, N50512.1, N78439.1, AI089934.1, N50443.1, R75994.1, AI418032.1, AW069428.1, H28047.1, AA722233.1, AA934810.1, AW194761.1, AI679985.1, N70890.1, R82859.1, AW576214.1, R82647.1, R60689.1, AI383079.1, AW603760.1, R40078.1, H92752.1, H39632.1, AW388643.1, R44445.1, AA320578.1, R92461.1, AWl 18280.1, D55592.1, AA857398.1, AA579529.1, R82696.1, D52213.1, AA152134.1, C14917.1, N47394.1, AA369996.1, N47395.1, AA150127.1, AI863820.1, AL079976.2, AA047526.1, AW545304.1, AW213944.1, AI844034.1, AI225307.1, AA175289.1, AW741826.1, AW324264.1, AW228128.1, AI849427.1, AI265537.1, AA175781.1, AI600081.1, AH 11343.1, AV331675.1, AW254554.1, AW253791.1, AI714131.1, AI029154.1, AI171980.1, AVI 15523.1, AV340409.1, AV227184.1, AW914053.1, AC015462.5, AC023782.2, AC044821.2, AC013713.4, AC021761.3, AC021241.3, AL355341.3, AL157875.4, AL049756.16, AC025190.4, AC016797.4, AC024935.8, AC008595.4, AC025060.3, AC023784.3, AC010907.3, AC022253.2, AC017109.2, AC018889.1, AL355378.1, ALl 18557.1,

SEQ ID NO.298 NGO-St-133 YS1783/T3 5' NM_014820.1, AB018262.1, Z19158.1, AP000007.1, AF102137.1, AE001690.1, Z80789.1, AB030817.1, AB025414.1, AE003713.1, AC004606.1, AL009175.1, AL139077.2, AL031012.1, AC007359.2, AC016752.2, AC003040.2, AF248484.1, AE003801.1, AE003616.1, AC007505.4, AE002280.1, AF127577.2, AF208226.1, AC007682.2, AC008175.2, AC015450.3, AC006481.3, AC012394.3, AC008040.7, AF166527.1, AC006463.3, AC006949.8, AC006578.5, AC006596.2, U00670.1, AC004293.1, AC005261.1, AC004473.1, AE001065.1, AL035536.1, Z82266.1, Z78065.1, AL078611.1, AL163255.2, AL163243.2, AL163207.2, S38096.1, AL138657.1, AL132957.1, AL021069.1. Z71182.1, U07798.1, AP001710.1, AP001698.1, AP001601.1, Z79997.1, AP000208.1, AP000247.1, X71802.1, AP000130.1, M95516.1, AW468485.1, W76094.1, AA449405.1, AW230655.1, AA313460.1, AI325788.1, AI892481.1, AA076346.1, AAl 16789.1, AA373986.1, AV145606.1, AW227769.1, AW320879.1, AI535287.1, Z19251.1, AA155457.1, AW765531.1, AW281101.1, AI430671.1, AA985348.1, W33868.1, AW656932.1, AW481973.1, AW410280.1, AW356980.1, AW336895.1, AW200321.1, AW050865.1, AL048825.1, AI478830.1, AA345311.1, AA278482.1, AA203592.1, W44281.1, R10075.1, T99341.1, T81329.1,

SEQ IDNO.299 NGO-St-134 combined; NM_003611.1, Y16355.1, Y15164.1, AC003037.1, ACOl 0682.2, AC006991.2, AC016707.2, AC008175.2, AC007379.2, AC009947.2, AF121351.1, AE003417.1, AC005039.1, AFl 17269.1, AF077408.1, U09819.1, AL161498.2, AF016655.1, AL050231.2, Z99121.1, X71360.1, AP002039.1, NC_001144.1, AC00941 1.2, AC010498.4, AF140536.1, AE003805.1, AE003690.1, AE003542.1, NM_002062.1, AC009514.2, AC006026.2, AC006065.3, AC005839.1, U44051.1, U85195.1, U01156.1, AC004289.1, AC005179.1, AC004475.1, U22383.1, AE000658.1, AL163244.2, AB016214.1, U51234.1, AL136501.2, AL035690.10, AL008732.1, AL021367.1, U62778.1, U10037.1, U01157.1, APOO 1699.1, AP001604.1, M24635.1, X75598.1, D16413.1, L23503.1, U01104.1, AA463600.1, Z46206.1, R93559.1, R18599.1, C03715.1, AA493510.1, AA610816.1, AI954758.1, Z24812.1, AV373707.1, AV274641.1, AV261266.1, AI482404.1, T63643.1, AW851555.1, AW782871.1, AW764717.1, AW199070.1, AW187754.1, AI867176.1, AI779970.1, AI778733.1, AI778732.1, AI777779.1, AV072748.1, AU052904.1, AI191468.1, AI061454.1, C25733.1, A A517468.1, AA491434.1, C07818.1, H30070.1, AC025449.3, AC068719.1, AC025246.5, AC017005.4, AC068601.3, AC024183.3, AC022848.3, AC069130.1, AC009235.2, AC007322.3, AC024236.3, AC008061.1, AC007965.2, AC007315.2, AC068541.3, AC053495.3, AC022486.3, AC010146.5, AL354667.1, AC058810.3, AC026605.3, AC069232.1, AC021756.11, AC024043.4, AC021311.4, AC018967.3, AC022602.1, AC020065.1, AL356234.2, AL354755.2,

SEQ ID NO.300

NGO-St-134

YS1695/T3 5'

NM_003611.1, Y16355.1, Y15164.1, AC003037.1, AC006991.2, AC016707.2, AC008175.2, AC007379.2, AC010682.2, AC009947.2, AF121351.1, AE003417.1, AC005039.1, AF077408.1, AL161498.2, AF016655.1, AL050231.2,

NC_001144.1, AC010498.4, AF140536.1, AE003690.1, AE003542.1, NM_002062.1, AC009514.2, AC006026.2, AC006065.3, U44051.1, U85195.1, U01156.1, AC005179.1, U22383.1, AE000658.1, AL163244.2, AB016214.1, U51234.1, AL136501.2, AL035690.10, AL008732.1, AL021367.1, U62778.1, U10037.1, U01157.1, AP001699.1, AP001604.1, M24635.1, L23503.1, U01104.1, AA463600.1, Z46206.1, R93559.1, R18599.1, C03715.1, AA493510.1, AA610816.1, AI954758.1, AV373707.1, AV274641.1, AV261266.1, AI482404.1, T63643.1, AW782871.1, AW764717.1, AW199070.1, AW187754.1, AI779970.1, AI778733.1, AI778732.1, AI777779.1, AV072748.1, AI191468.1, AI061454.1, AA517468.1, AA491434.1, C07818.1, AC025449.3, AC068719.1, AC007322.3, AC024236.3, AC008061.1, AC007965.2, AC007315.2, AC068541.3, AC053495.3, AC022486.3, AC069130.1, AC009235.2, AC024183.3, AC022848.3, AC068601.3, AC010146.5, AL354667.1, AC058810.3, AC026605.3, AC069232.1, AC021756.11, AC018967.3, AC020065.1 , AL356234.2, AL354755.2, AC044879.3, AC009545.4, ACOl 8905.4, AC068284.2, AC023596.7, AC023105.4, AC068275.2, AC025586.1, AC022448.3, AC010423.5, ACOl 1378.3, ACOl 1404.4, AC019198.2, AC044779.3, AC026076.2, AC009692.3, AC025038.3, AC026529.2, AC034290.1, ACOl 5988.3, AC022937.3, AC019039.2, AC021936.1, AC021312.1, AC020414.1, AC012565.2, AC014964.1, AC007645.3, AL139147.3, AL133402.10, AL162739.4, AL160167.5, AL353621.2, AP001998.1, AP000916.2, AP001524.1, AP001491.1, AP000723.1. AP000629.1,

SEQ ID NO.301 NGO-St-134 YS1695/T7 3' NM_003611.1, Y16355.1, Y15164.1, AC003037.1, AC007379.2, AC016752.2, AC008175.2, NM_007845.1, S77750.1,

U12565.1, AC024823.1, AE003682.1, AE002142.1, AF165124.1, AC005220.1, AL021328.1, AE002140.1, NM_010077.1, AF143381.1, AC003042.1, ALl 17375.12, Z99772.1, X55674.1, D67043.1, AC005310.2, AC009327.6, AC008125.9, U21319.1, AC005371.1, AC002090.1, AJ235271.1, AB026658.1, AI916605.1, AI867405.1, AI971431.1, AI867404.1, AI376969.1, AI769120.1, AI634116.1, AI245948.1, AW 167287.1, AA399610.1, AA173950.1, AA778870.1, AWl 18555.1, AI627406.1, AI769378.1, AI804265.1, AI309530.1, AW296642.1, D52284.1, AI277389.1, AI304731.1, N57735.1, AI280957.1, AA504821.1, AI049632.1, C14646.1, AA780326.1, C 14712.1, AA994778.1, R41679.1, AI916018.1, Tl 6276.1 , N57749.1 , AAl 73595.1 , AA824530.1 , AA621466.1 , AW009492.1 , D53159.1 , AI917863.1 , H05597.1 , AW885416.1, AI908207.1, D60992.1, AI908204.1, AI561264.1, AI277708.1, W35241.1, AI620904.1, Z41831.1, AI277709.1 , D53722.1 , AI277707.1 , AA428032.1 , AA514458.1 , D60582.1 , D80593.1 , AWl 18344.1 , AI824750.1 , AI719888.1, AI908201.1, D60909.1, R93560.1, D80428.1, AW887698.1, AW450863.1, AI333241.1, AA707111.1,

AA693788.I, AW072670.1, AI022424.1, C14580.1, AI471729.1, AA398975.1, AI719895.1, AW271458.1, W23787.1, AW416841.1, AW554784.1, AW542764.1, AI480837.1, AW785419.1, AW785418.1, AI554988.1, AA634447.1, AW485325.1, AW375050.1, AW297567.1, AA871518.1, AA869166.1, AV197217.1, R14712.1, AW563271.1, AW270811.1, AI507728.1, AA247528.1, AC025449.3, AC068541.3, AC022486.3, AC007322.3, AC007965.2, AC007315.2, AC018789.2, AC008061.1, AC022783.2, AC020972.1, AC063924.3, AC008611.4, AC026910.2, AC021619.3, AC006879.2, AC006796.1, AC068165.1, AC021471.2, AC010873.3, AC015517.2, AL137069.2, AL158045.2, AC013318.4, AC063960.2, AC034138.2, AC012686.3, AC018872.2, AL137125.2, AL136218.7, AL353607.2, SEQ ID NO.302 NGO-St-134 YS318/T3 5'

NM_003611.1, Y16355.1, Y15164.1, AC003037.1, AC010682.2, AC007379.2, AC006991.2, AC008175.2, AC009947.2, AE003417.1, AC005039.1, AF117269.1, U09819.1, AF016655.1, AL050231.2, Z99121.1, X71360.1, AP002039.1, NC_001144.1, AC009411.2, AF140536.1, AE003690.1 , NM_002062.1 , AC009514.2, AC006026.2, AC006065.3, AC005839.1, U44051.1, U85195.1, U01156.1, U22383.1, AE000658.1, AL163244.2, AB016214.1, U51234.1, AL035690.10, AL008732.1, AL021367.1, U62778.1, U10037.1, U01157.1, AP001699.1, AP001604.1, M24635.1, X75598.1, D16413.1, L23503.1, U01104.1, R93559.1, AA463600.1, C03715.1, Z46206.1, R18599.1, AA493510.1, Z24812.1, AV373707.1, AV274641.1, AV261266.1, AI482404.1, AW851555.1, AW782871.1, AW764717.1, AW199070.1, AWl 87754.1, AI867176.1, AI779970.1, AI778733.1, AI778732.1, AI777779.1, AU052904.1, C25733.1, AA517468.1, AA491434.1, C07818.1, H30070.1, AC025449.3, AC068719.1, AC025246.5, AC017005.4, AC068601.3, AC024183.3, AC022848.3, AC069130.1, AC009235.2, AC068541.3, AC022486.3, AC007322.3, AC024236.3, AC008061.1, AC007315.2, AC010146.5, AL354667.1, AC058810.3, AC026605.3, AC069232.I, AC024043.4, AC021311.4, AC022602.1, AC020065.1, AL356234.2, AC044879.3, AC009545.4, AC018905.4, AC026076.2, AC026925.2, AC022937.3, AC016803.2, AC019039.2, AC012507.3, AC020414.1, AC007645.3, AC005059.1, AL139147.3, AL133402.10, AL162739.4, AP001998.1, AP000723.1,

SEQ ID NO.303 NGO-St-134 YS318/T7 3'

NM_003611.1, Y16355.1, Y15164.1, AC003037.1, AC007379.2, AC016752.2, AC008175.2, AC024823.1, AE003682.1, AE002142.1, AC005046.3, AF165124.1, AC005220.1, AE002140.1, AF143381.1, AC005922.1, AC003042.1, AL121674.12, AL033378.12, ALl 17375.12, Z99772.1, AL031285.1, D67043.1, AC005310.2, AC006029.2, AC009327.6, AC005827.3, AC005371.1, AJ235271.1, AL137189.1, AL008729.1, AB026658.1, AI867405.1, AI916605.1, AI971431.1, AI376969.1, AI867404.1, AI769120.1, AI634116.1, AI245948.1, AAl 73950.1, AA399610.1, AA778870.1, AW167287.1, AWl 18555.1, AI769378.1, AI627406.1, AI804265.1, AI309530.1, AW296642.1, AI277389.1, AI304731.1, N57735.1, D52284.1, AI280957.1, AA504821.1, AI049632.1, AA780326.1, C14646.1, AA994778.1, R41679.1, AI916018.1, C14712.1, T16276.1, N57749.1, AW009492.1, AA824530.1, AA621466.1, AI917863.1, D53159.1, AAI73595.1, H05597.1, AW885416.1, D60992.1, W35241.1, AI908207.1, AI620904.1, Z41831.1, AI908204.1, AA428032.1, AA514458.1, D53722.1, D60582.1, AI561264.1, D80593.1, AI277708.1, AI277709.1, AI824750.1, AI719888.1, AI277707.1, R93560.1, D60909.1, D80428.1, AW887698.1, AWl 18344.1, AI908201.1, C14580.1, AI471729.1, AI719895.1, AW450863.1, AW072670.1, W23787.1, AW271458.1, AI333241.1, AA398975.1, AI022424.1, AA707111.1, AA693788.1, AW416841.1, AW554784.1, AW542764.1, AI480837.1, AW785419.1, AW785418.1, AI554988.1, AW485325.1, AV197217.1, R14712.1, AW563271.1, AW270811.1, AWl 19241.1, AI507728.1, AA247528.1, AC025449.3, AC068541.3, AC022486.3, AC007322.3, AC007965.2, AC007315.2, AC018789.2, AC008061.1, AC024524.3, AC063924.3, AC008611.4, AC021619.3, AC006796.1, AL136367.2, AL158205.4, AC021471.2, AC023409.1, AC010873.3, AC012501.1, AL159970.8, AP001318.1, AC012543.3, AC053523.2, AC008890.3, AC008732.4, AC034138.2, AL137125.2, AL136218.7,

SEQ ID NO.304 NGO-St-135 5 'combined;

NM_014781.1, D86958.1, Z35085.1, X82318.1, NC_001865.1, AB001684.1, Z72514.1, AC002302.1, AC007486.1, AL049755.2, X79489.1, Z35853.1, AC010151.3, AC009234.3, AF083915.1, AL139074.2, AL132862.1, AC013737.4, U36927.3, AE003692.1, AC006473.2, AF056336.1, AL136363.4, AW502603.1, AI632607.1, AI889925.1, R59196.1, Z40222.1 , H28996.1 , Z30060.1 , AW663145.1 , N36767.1 , T32056.1 , T39659.1 , T40715.1, AA063364.1 , A W271526.1 , AA795138.1, AW771911.1, AA998419.1, AI466480.1, AA880393.1, AI482282.1, AI841402.1, W52752.1, AI786567.1, AV221321.1, BB006621.1, AV254733.1, AW865505.1, AV330249.1, AL044138.1, AI655038.1, AV316950.1, AV348716.1, AV274459.1, AV317688.1, AV280612.1, AV352758.1, AV349442.1, AV245740.1, AV318689.1, AV330001.1, AV328749.1, AI138828.1, AA047474.1, R17528.1, R13828.1, T38143.1, AW861328.1, AW426185.1,

AI980387.1, AI959585.1, AI621380.1, Z29358.1, AW851165.1, AV440128.1, AW203956.1, AV347279.1, AI830629.1, AI488952.1, AI361260.1, AI281023.1, AI276138.1, AA828299.1, AA682840.1, AA449644.1, AA425466.1, AC018960.3, AC037464.2, AC018621.3, AC023756.2, AC024448.2, AC016201.5, AL161663.1, AC023777.3, AC006279.6, AL022285.6,

SEQ ID NO.305

NGO-St-135

YS374 T3 5^*

NM_014781.1, D86958.1, Z35085.1, X82318.1, AL049755.2, D87675.1, AP001442.1, AP000141.1, AP000089.1, AC010151.3, AC009234.3, AC005771.1, AC006761.1, AE003692.1, AF172282.1, AC006478.2, AE001577.1, AC006473.2, AC006222.1, AF100669.1, AF016420.1, AL050322.10, AL022166.1, AB009049.1, AI889925.1, AW663145.1, H28996.1, Z40222.1, N36767.1, T32056.1, R59196.1, T39659.1, T40715.1, AA063364.1, AW271526.1, AA795138.1, AW771911.1, AA998419.1, AI482282.1, AI841402.1, AV221321.1, BB006621.1, AV254733.1, Z30060.1, AW865505.1, AV330249.1, AI655038.1, AV316950.1, AV348716.1, AI786567.1, AV274459.1, AV317688.1, AV280612.1, AV352758.1, AV349442.1, AV245740.1, AV318689.1, AV330001.1, AV328749.1, AI138828.1,

AA047474.1, R17528.1, R13828.1, R20722.1, AW861328.1, AI980387.1, Z29358.1, AW851165.1, AW816256.1, AW572236.1, AV391062.1, AW328120.1, AV347279.1, AV220950.1, AW140056.1, AI830629.1, AI281023.1, AI276138.1, AI042194.1, AA682840.1, AA411650.1, AA194887.1, AA189098.1, H85292.1, R55580.1, ACOl 8960.3, AL138741.3, AC022235.2, AC022198.2, AC023756.2, AL161663.1, AC023777.3, AC022224.20, AC019223.2, AL109767.2, AC022148.4, AC009138.5, AC016516.3, AC026891.1, AC016272.3, AC013530.3, AL354668.1, AL162211.3. AL049185.4,

SEQ ID NO.306 NGO-St-135 YS382/T3 5'

NM_014781.1, D86958.1, NC .001865.1, AB001684.1, AC006443.1, Z72514.1, AC004401.2, AC002302.1, AC007486.1, X79489.1, U41015.1, Z35853.1, Z35852.1, AL050403.13, AB019235.1, AC013737.4, U36927.3, AF121898.1, AE001381.1, AC004171.1, AF056336.1, AL136363.4, AL109983.1, AW502603.1, AI632607.1, Z30060.1, R59196.1, AI466480.1, AA880393.1, W52752.1, Z40222.1, H28996.1, AI786567.1, AL044138.1, T39659.1, T38143.1, AW426185.1, AI959585.1, AI621380.1, AV440128.1, AW614639.1, AJ396349.1, AW467130.1, AW251790.1, AW251721.1, AW203956.1, AV381555.1, AW139206.1, AV384482.1, AW047876.1 , AI996020.1 , AI849553.1, AI776841.1, AI774351.1, AU073206.1, AI712752.1, AI584023.1, AI488952.1, AI474049.1, AI373038.1, AI361260.1, AH 75635.1, AI081464.1, C92808.1, AA828299.1, AA449644.1 , AA425466.1 , AA397984.1, AA192413.1, W80808.1, N34826.1, R27823.1, ACOl 8960.3, AC037464.2, AC024448.2, AC012389.10, AL356295.3, AL160257.3, AC037454.2, AC064864.1, AC013328.5, AC004153.5, AC010985.3, AC006903.1, AL354763.1,

SEQ ID NO.307 NGO-St-135 YS382/T73'

NM H4781.1, Z35085.1, D86958.1, X82318.1, AE003435.1, AC007371.16, AC007489.3, AC024763.1, AE003558.1, U80446.1, AW771911.1, AW271526.1, AI138828.1, AI655038.1, AA047474.1, R13828.1, AI122747.1, AA047435.1, R23393.1, R55580.1, H10270.1, AA374617.1, W60007.1, Rl 7528.1, C75251.1, R22753.1, F13181.1, Fl 1154.1, AI889925.1, N36767.1, R20722.1, AA952920.1, T77023.1, AA206152.1, AI153537.1, AI841402.1, AA795138.1, AA063364.1, AA692714.1, AV316950.1, AI785170.1, AA200762.1, AV330249.1, AA998419.1, AV274459.1,

AA976511.1, AA823667.1, AV221321.1, AW130616.1, BB006621.1, R16741.1, AV254733.1, AV280612.1, AV317688.1, AV349335.1, AV348716.1, AA808066.1, AW551190.1, AI627011.1, A V318248.1, AI447566.1, AI302306.1, AA974918.1, T24196.1, AC018960.3, AC051613.3, AC014392.1, AC013253.6, AC013535.4, AC016130.13, ACOIOI 13.4, AC017388.1, AC010557.2, AC006714.2, AC006746.1, AL355924.1,

SEQ ID NO.308

NGO-St-136

YS042/T3 5'

NM_002707.1, AX002424.1, Y13936.1, U81159.1, NM_008014.1, U42383.1, AX002422.1, AL049551.1, L31397.1, AF249327.1, NM_011577.1, AF105069.1, L42456.1, U41021.1, AJ009862.1, M57902.1, AB009874.1, AC006592.5, NM_011668.1, NM_010473.1, NM_008272.1, AFl 14039.1, AC007130.2, AF158597.1, AF132218.1, AF082835.1, AL022070.1, U18428.1, U96636.1, U82122.1, AL138558.1, U61980.1, X55318.1, X07647.1, M35603.1, AC010285.4, AC003692.1, AC010556.4, AC005908.1, AC005943.1, Z66566.1, AL136039.2, AL109967.2, Z85987.13, AP001595.1, AI650583.1, AI992326.1, AW384902.1, AW239336.1, AI879664.1, AW249422.1, AA070392.1, AW577345.1, AW659941.1, AW659925.1, AL042520.1, AW367060.1, AW361618.1, AI894150.1, AA211434.1, AW672699.1,

AW161662.1, AI928871.1, AA320736.1, AW850023.1, AI878909.1, AW849906.1, AI879284.1, T06191.1, AW490146.1, AA383664.1, H32905.1, AW163699.1, D76591.1, AAl 15688.1, AWl 60907.1, AW082745.1, AI417405.1, AA834611.1, AA085449.1, AI878881.1, AI929038.1, AA074643.1, N88715.1, AW578051.1, AW382863.1, W39347.1, W34891.1, AW321752.1, AL045879.1, AA171301.1, W65536.1, AA383628.1, AI879435.1, AW062337.1, AW630504.1, AW872109.1, AA510019.1, AW871903.1, AW782552.1, AW760420.1, AI940409.1, AI323364.1, AA646479.1, AA190384.1, AC009427.2, AC025903.1, AC007497.2, AC027499.3, AC025642.2, AC022174.2, AL356108.2, AL158171.3, APOOl 128.1, AC026954.3, AC008006.3, AC027299.6, AL158816.4, ALl 17187.2, AC064846.3, AC026413.2, AC016575.6, AC026833.2, AC025898.2, AC016837.3, AC015677.4, AC021697.4, AC023379.2, AC023804.7, AC008841.1, AC024264.1, AC012531.1, AF165178.1, AL035477.5, AP001099.1,

SEQ ID NO: 309

NGO-St-136

YS042/T7

NM_002707.1, Y13936.1, AX002424.1, NM_008014.1, U42383.1, U81159.1, U83913.1. Z81114.1, Z78415.1, AL163233.2, U28789.1, AP001688.1, AP000961.2, AF213465.1, AC004519.1, AC002428.1, AC004839.1, AC007237.3, AF147259.1, U23527.1, AC004503.1, AL161507.2, AL163254.2, AL135744.2, AL049539.21, Z71782.1, AP001709.1, X87579.1, AP000204.1, AP000244.1, AP000126.1, M20814.1, AI623188.1, AI949680.1, AI769584.1, AW003495.1, AI016791.1, AW514319.1, AI674866.1, AA708807.1, AI954672.1, AI690420.1, AW771608.1, AW129519.1, AI563921.1, AA418416.1, AL044111.1 , AI432554.1 , AI634705.1, AI570350.1, AW087864.1, AA938139.1, AI917417.1, AI802218.1, AI432562.1, AW250025.1, AW675447.1, AI697620.1, AI686700.1, AI359192.1, AI634891.1, AI587529.1, AI290844.1, AI619769.1, AW163096.1, AI150541.1, N53494.1, AI933325.1, AA190579.1, AI687672.1, AI204201.1, AI435812.1, AI335028.1, AW079871.1, AI587523.1, AI885074.1, AA831968.1, AA292839.1, AI378193.1, AA418531.1, AAl 15707.1, AI983072.1, AI991100.1, AL046114.1, AA132539.1, AI057142.1, AI962687.1, AI825350.1, AI637949.1, AI754481.1, AA460426.1, N36716.1, AW516535.1, AI445408.1, AAl 26965.1, N26077.1, AA613447.1, AA133683.1, AA994318.1, T30419.1, AI207138.1, AA470639.1, AW612812.1, AA151641.1, AA079391.1, AI683064.1, AI655486.1, W38314.1, AW806697.1, AW605433.1, AI018391.1, AA580007.1, AA398657.1, AW136714.1, AA465129.1, AA070393.1, AA465723.1, W38641.1, AI634337.1, C02081.1, AI675741.1, AI372924.1, AA621622.1, AI909888.1, AA587456.1, F22497.1, Z39444.1, AW361020.1, AI909859.1, AI690302.1, R53936.1, AI963691.1, AL160290.3, AC048362.2, AC027484.3, AC026473.3, AC009169.4, AC009664.4, AC022478.3, AC010735.3, AC015622.3, AL137066.5, AL009206.1, AC037452.2, AC068637.3, AC069218.1, AC024094.8, AC006337.3, AC019043.3, AC040940.1, AC020685.3, ACOl 1849.3, AC009549.3, AC021 1 14.3, AC021002.3, AC016989.4, AC018717.5, AC020892.3, AC009665.4, AC016746.3, AC012529.1, AC004624.6, AC007913.1, AC007438.6, AC006086.7, AC006087.12, AC004670.1, AC005141.1, AL162264.4, AL355531.1, AL354876.1, AP001562.1,,

SEQ ID NO: 310

NGO-St-137

YS1671/T3

NM_015873.1 , D88154.1, AP000497.1 , J03781.1, AC007630.3, AL049867.2, AC008989.6, NM_009509.1, AF009332.1, X85787.1, Z94160.1 , ALl 63292.2, AP001747.1, AP001625.1, M98454.1, D26083.1, AL040451.1, AW226642.1,

AW344693.1, AA222407.1, AA272458.1, AA10991 1.1 , AW049791.1 , AI842717.1, AW336334.1, H31419.1, AI944648.1, AA871446.1, AJ003346.1, AC015624.2, AC055818.1, AC015627.1, AC009292.7, AC021133.3, AL109918.24, AC023547.3, AC025871.3, AC058789.9, AC064818.3, AC027567.2, AC021876.3, ACOl 1132.4, AF235106.1, AC009837.2, AL136090.10, AL136966.6, AP001274.,

SEQ ID NO: 311

NGO-St-137

YS1671/T7

NM_015873.1 , D88154.1, AP000497.1, AE003608.1, AC005750.1, AC005164.1, AC004453.1, AE002079.1, AC007870.3, L48729.2, AC00621 1.1, U50713.1, U52431.1, AP000003.1, AB004870.1, AI207789.1, AI828390.1, AI887514.1,

AI991204.1, AW087315.1, AI004782.1, AI394648.1, AW627720.1, AI660044.1, AA088690.1, AI699257.1, AA088827.1, AI440449.1, T57294.1, AW197506.1, AA641469.1, AL040452.1, AA992660.1, W85454.1, AV270064.1, AV143508.1, AW701384.1, AW908944.1, AW701603.1, AI182951.1, AW911867.1, AW665415.1, AW629286.1, AW593227.1, AW575674.1, AW573162.1, AW573006.1, AW510703.1, AW340616.1, AW340493.1, AW274644.1, AWl 83086.1, AW104924.1, AW082305.1, AI927494.1 , AI868632.1, AI829672.1, AI827875.1 , AI810093.1, AI809958.1, AI808895.1, AI805139.1 , AI740990.1, AI685360.1, AI290316.1 , AI276754.1 , AI273268.1, AI247350.1, AI222006.1 , AA919014.1 , AA913475.1, AA41 1451.1, AC015624.2, AC015627.1, AC022034.3, AC020275.1, AC018448.8, AL139236.3, AC069272.3, ACOl 6257.6, AC009466.7, AC024947.2, AC026456.2, AC032008.2, AC027694.2, AC023136.3, AC024720.3, AC023437.2, AC016168.3, AC020778.4, AC010833.3, AC018492.3, AC024158.1, AC021911.1 , AC004958.1, AL139342.4, AL133291.3, AP001031.2, AP001802.1, AP001500.1 , AP000880.1,

SEQ ID NO: 312

NGO-St-138

YS171/T3 NM_002310.2, X61615.1, NM H3584.1, S73495.1, D26177.1, S73496.1, D17444.1, D86345.1, U97364.1, M95099.1, AC010140.3, AC006446.3, AE003824.1 , AE003687.1, AE003458.1, AF077407.1, AC004829.2, AC005965.1, AC003688.1, U15422.1, AL132902.2, AL132950.1, AB005248.1 , AE003742.1, AE003521.1, U89335.1, AC006193.3, AF086440.1, Z81565.1, Z47547.1, AL353871.1, AL138664.1, AL136538.1, AL049550.5, AL035423.4, U19467.1, U28735.1, AJ224683.1, Zl 1527.1, AB000565.1, T18495.1, AA207338.1, AI226136.1, W20740.1, AI894070.1, AA023181.1, All 95387.1, AA24531 .1, AW626804.1, AW529846.1, AW529284.1, AW527135.1, AJ397726.1, AW434719.1, AW355500.1, AW299470.I , AV334964.1, AV294188.1, AW083883.1, AI715801.1 , AI575955.1 , AA997228.1, AI415987.1, AIOl 1427.1, AA534664.1, AA440412.1 , AA193084.1, W81340.1, W81339.1, W79447.1, N42705.1, D69835.1 , H59829.1, AC010457.5, AC016324.4, AC022850.3, AC023948.2, AC068662.1, AC025882.2, AC015938.3, AC024169.1 , AL354889.4, AL355587.3, AL161660.6, AL162852.3, AC026954.3, AC010176.7, AC010395.5, AC012610.4, AC008782.4, AC027785.2, AC021621.3, AC013642.3, AC019195.4, AC022040.2, AC025285.1, AC021883.2, AC020182.1 , AC020286.1, AC013646.3, AC008232.3, AC018232.1, AC007770.4, AC007822.3, AL158053.2, AC020639.4, AC068892.1, AC010376.3, AC012316.4, AC068216.1, AC009627.3, AC026038.2, AC009833.3, AC019141.3, AC013466.2, ACOl 1172.4, AC010003.5, AC009368.5, AC021801.1, AC019524.1, AC020018.1, AC008200.3, AC007910.1, AC006714.2, AL139190.4, AL139098.4, AL137780.2, AL160263.3, AL353606.2,

SEQ ID NO:313

NGO-St-138

YS171/T7 NM_002310.2, U66563.1, AC018748.3, AF220294.1, AC020728.4, AC009526.4, AC004861.1, AC002457.1, U12386.1, AF064866.1, AE000722.1, AF043945.1, U23517.1, AC000103.1, AL355916.1, AL163283.2, U19289.1, U02537.1, AB017064.1, AC006991.2, AC007661.2, AE003735.1, AE003696.1, AE003562.1, AE003559.1, AC009947.2, AC004746.1, AC004081.1, AF077407.1, AF051985.1 , NM_000810.2, AC004453.1, AC004993.1, AC006044.2, U42580.2, AF039907.1, AC007159.4, AC006409.2, AC005965.1, U89714.1, AC005176.1, Z83105.1, AL022289.1, U73646.1, U73642.1 , ALl 63261.2, AL121787.22, U65744.1 , AL161666.2, X70645.1, X96995.1, L08485.1, AP00I 716.1,

AP000188.1, AP000044.1, AP000298.1 , AP000112.1, AI915539.1, AI439137.1, N67017.1, AI140597.1, R38064.1, R38159.1, AW766681.1, AW760222.1, AW645026.1, AW644379.1, AW643145.1, AI769415. I, AA825445.1, AA601263.1, AW633848.1, AW384967.1, AV361643.1 , AI856958.1 , AI807646.1, AI787356.1, AA833639.1 , AA631386.1, AA322964.1 , AAl 76759.1, D68013.1, AC010457.5, AC040167.2, AC008074.2, AC021418.3, AC026685.1, AC018821.3, AC018829.3, AC007906.2, AC068278.2, AC026811.2, AC068398.1, AC018958.2, AC024235.2, AC040994.1, AC024454.2, AC019295.3, AC022600.1, AC004133.1, AL138931.2, AL157936.3, AL163540.3, AP001536.1, AP000609.2, SEQ ID NO: 314 NGO-St-139 YS313/T3

NM_004404.1, AF038404.1, D28540.1, D63878.1, NM_010891.1, D49382.2, AC005104.1, L33246.1, X67202.1, NM_004574.1, AF073312.1, U88870.1, U88829.1, AF035811.1, NM_011129.1, X61452.1, AE003722.1, AF129756.1, AJ012008.1, AP000504.1, AE003568.1, AF181897.1, AFl 13831.1, AE000578.1, AEOOl 491.1, AF063866.1, AFO 17777.1, AL163002.1, AL162751.1, U97193.1, M65026.1, Z98547.1, X57924.1, AP001313.1, D64003.1, AB005240.1, D10774.1, NC_001139.1, AE003801.1, AE003691.1, AC005067.2, AC007681.3, AC006949.8, AC006112.2, AC006602.1, AC006502.2, AF 106564.1, U00067.1, AC004293.1, AF014008.1, Z72946.1, ALl 17193.1, AL137230.2, AL035685.21, AJ243530.1, AL021182.1, AL049569.13, AL022397.1, X85807.1, Z72944.1, X57185.1, AJ224373.1, X88845.1, U19801.1, L17338.1, AL043232.2, AA503494.1, AI299913.1, AI557336.1, AA134778.1, AA908712.1, AA516460.1, AW804638.1, AA207185.1, AA346077.1, AA346067.1, AW517043.1, AW580618.1, T79554.1, AA703550.1, AW580614.1, AW175610.1, AW175626.1, AW901420.1, AA309749.1, AW196938.1, AW175616.1, R58037.1, H34478.1, H34850.1 , AA063813.1, AA405068.1 , AI362531.1, AI588750.1 , AW918329.1 , AI740549.1 , AA278469.1 , AA278468.1 , L44311.1, AW362022.1, AA091277.1, AI191427.1, W07036.1, AW242840.1, AI801603.1, AW380702.1, AW364487.1, AW379484.1, N85237.1, W39483.1, AW607052.1, AI557335.1, AU000539.1, AA067306.1, AJ394459.1, AWl 28456.1, R89377.1, AW911380.1, AI287193.1, AW298883.1, AJ392338.1, AA325361.1, AW903179.1, AI991202.1, AI765951.1, AI632238.1, AI459499.1, AA780116.1, AA325651.1, AA324802.1, AA055270.1, AA024634.1, W69297.1, AW209482.I, AI894076.1, AI877025.1, AI323320.1, AI181122.1, AA023716.1, AI140073.1, AW69I387.1, AW637056.1, AI412920.1, AI411171.1, AH 16225.1, AA097604.1, N57875.1, AW462213.1, AI881739.1, AI584411.1, C57917.1, AC019318.2, AC022958.1, AC012304.2, AC011757.10, AC009395.5, AC018015.1, AL132713.5, AC068059.2, AC008547.4, AC009563.3, AC007131.3, AC055122.1, AC018574.3, AC024722.2, AC025834.1, AC013980.1, AF165425.1, AL353738.7, AL161432.3, AC022278.9, AC023507.5, AC019070.2, AC069047.1, AC020594.2, AC062030.2, AC067961.3, AC025188.3, AC024579.3, AC020927.4, AC010477.6, AC010475.3, AC008933.4, AC008515.5, AC008485.3, AC010289.3, AC027023.2, AC027676.2, AC008068.3, AC016881.4, AC027042.2, AC053481.1, AC037477.1, AC021842.3, AC018953.5, AC015810.3, AC018684.2, AC024518.2, AC021000.3, AC0I6841.2, AC007710.10, AC023958.2, AC007223.1, AC016760.3, AC012354.3, AC017587.1, AC014457.1, AC008358.3, AL355335.3, AL109931.15, AL356372.1, AL139812.5, AL034372.30, AL133271.15, AL121952.6, AL162332.1, AL133168.1, Z98855.1, AP001591.1, SEQ ID NO:315 NGO-St-139 YS313/T7

NM_004404.1, AC005104.1, AF038404.1, D63878.1, D28540.1, NM_010891.1, D49382.2, AL031779.5, Z98754.1, AL163229.2, AP001684.1, AP000657.1, AP000561.1, NM_015759.1, AF017369.1, AF038172.1, AE003820.1, AC004615.1, AC008165.3, AC005078.1 , AC006572.2, AC005184.1 , AC005242.1 , AL049557.19, AC000386.1 ,

AL157991.1, AL121963.10, AL132846.1, Z68276.1, AP001306.1, M63453.1, AI753689.1, AH 14531.1, AI754501.1, AI088934.1, AW152364.1, AI609395.1, AA639591.1, AI160331.1, AI951387.1, AI955165.1, AI573059.1, AW473653.1, AI956125.1, AI126301.1, N21100.1, AI089658.1, AI632807.1, AW273787.1. N35895.1, AW020474.1, AI094932.1, AW026345.1, N67318.1, AW339045.1, AW886537.1, AA234940.1, AA137035.1, AW514047.1, AI346269.1, AA218642.1, N67464.1, AA516108.1, AI829564.1, AI683327.1, AI355722.1, AA516499.1, AW022200.1, AA234941.1, AA206067.1, AI564619.1, AW769271.1, AI357439.1, AW517058.I, AI635685.1, AI087118.1, AI273328.1, AI143819.1, AI051872.1, AW474968.1, AW167451.1, AI754942.1, AI708338.1, AA775507.1, AA565842.1, AI130699.1, AA809247.1, AA430153.1, T15553.1, AW023986.1, AW469297.1, AI039303.1, AI521676.1, AA971524.1, AA487437.1, AW302623.1, AI880684.1, AI143019.1, AA812690.1, AI081421.1, AA043265.1, AW771795.1, AA599961.1, AA181698.1, AA071074.1, AI754299.1, AI355732.1, AI027964.1, AI338308.1, AA808182.1, AA209392.1, AW192277.1, AI858793.1, AI304415.1, AI225151.1, AI139335.1, AW337224.1, AI434203.1, AI565741.1, AI217047.1, AI190711.1, AW129449.1, N25544.1, N53355.1, AW771405.1, AI636810.1, AI096434.1, AA928349.1, AA599844.1, AI024553.1, AI830555.1, AC067872.1, AC012304.2, AC019318.2, AC013382.3, AC022958.1, AL137008.2, AC027057.3, AC024706.3, ACOl 1210.3, AL121819.2, AC010600.3, AC008525.4, AC027182.1, AC009146.2, AL133383.6, AC058801.2, AC027523.2, AC022912.3, AC025164.8, AC021662.8, AC018548.7, AC021873.7, AC012514.8, AC069223.1, AC068763.2, AC069025.1, AC069013.1, AC068070.2, AC068708.2, AC007511.2, ACOl 1209.3, AC067953.2, AC027344.2, AC026410.2, AC010419.3, AC046162.2, AC027812.2, AC067899.1, AC026935.2, AC020684.4, AC020778.4, AC024053.2, AC022986.3, AC021111.3, AC025706.3, AC013303.3, ACOl 1774.4, AC024503.2, AC022923.3, AC016515.3, AC013637.3, AC023560.2, AC022568.3, AC025489.1, AC008853.1, AC005472.14, AC007472.5, AC022016.2, ACO 14851.1, AFl 66490.1, AC007702.1, U82207.1, AL157761.2, AL157402.2, AL356218.1, AL353136.3, AL132868.12, AL355373.1, AL354809.1, AL161933.3, AL353731.1, AL159980.3, AL136360.7, AL135818.2, AL035066.20, AL021573.1, AP001848.1, AP001487.1, APOO 1486.1, AP001018.1, AP000875.1, AP000789.1,

SEQ ID NO: 316 NGO-St-140 YS2312/T3

NM_004724.1, U54996.1, AJ250458.1, AE003557.1, AC003949.1, AJ012166.1, U39676.1, AL031785.1, AC006332.3, AF244289.1 , AF244276.1 , AF244264.1 , AF244262.1 , AF244261.1, AE003628.1 , AC003060.1 , AC004830.1 , AC004887.2, AE001709.1, AC005454.1 , AF081108.1, AC005293.1, Z81567.1. Z69386.1 , AL133334.16, S70930.1, AL138655.1, M80829.1, AL049861.18, AL137961.1, AW107591.1, AA693260.1, AV046551.2, AV147645.1, AA692808.1 , AJ396591.1, AJ395373.1, AW375854.1, AV362443.1, AW003698.1, AI887627.1, C77594.1 , AA541074.1, Z92701.1 , AA148712.1, AC036188.2, AC068190.1, AC036226.1 , AC020808.2, AP001882.1, AP000913.2, AP000744.1, AC021176.3, AC006591.12, AC018042.1, AC008303.1, AC026900.3, AC027690.4, AC027341.2, AC010276.5, AC024383.3, AC023774.3, AC025551.3, AC019145.5, AC013693.3, AC023632.1, AC022652.1, AC010885.3, AC018617.2, AL138884.3, AL138796.3, AL136086.3, AL096819.12, AC036166.3, AC027821.3, AC060778.2, AC009783.7, AC012040.9, AC068764.2, AC012526.20, AC019041.3, AC053479.2, AC036181.2, AC060829.2, AC021082.2, AC010631.4, AC026474.3, AC026464.3, AC018646.1, AC064794.1, AC019055.3, AC024067.3, AC053522.1, AC051661.1, AC026561.2, AC012130.2, AC019058.3, AC023881.2, AC021469.3, ACOl 1562.4, AC015523.3, ACOl 1972.3, ACOl 1277.4, AC023013.2, AC024630.1, AC020607.2, AC021317.2, AC015973.1,

AC013268.1, AC009849.6, AC012796.1, AL355853.3, AL355005.2, AL356117.1, AL1361 18.3, AL135915.2, Z98876.1 ,

SEQ ID NO: 317 NGO-St-140 YS2312/T7

NM KM724.1, U54996.1 , AF003951.1, AC008085.1, AC004520.1, AF011889.1, AE001131.1, Z99162.1, AL031275.1, AP002068.1, AE003825.1, AE003435.1, AC007636.19, AC018833.3, NM_006389.1, AC005483.1, AC007395.3, ACOl 1663.5, AC005966.1, AC006442.1, AF004556.1, U65785.1 , AC004518.1, AF045265.1, AC004237.1, AL163002.1, Z75552.1 , AL096712.20, AL022397.1, J02027.1, V01170.1, Z73477.1, AB005240.1, AB005531.1, D86408.1 , AW235646.1, AA599145.1, AW575031.1, AW851090.1, AW057979.1, AI290602.1, AA076428.1, AI937662.1,

AI025335.1, AI680594.1, AI810264.1, AA416982.1, AA252056.1, R38913.1, AW170221.I , Z41148.1, AA251899.1, R01885.1, T90448.1, AA812446.1, AW851089.1, T82954.1, AI684285.1, C21581.1, AI230413.I , AA940442.1, AA163727.1, AI060892.I , AV428214.1, AW64421 1.1, AW087475.1, AW045499.1, AI976733.1, AV048357.1, U21463.1 , AA574864.1, AA365430.1, AA298325.1, AA175204.1, C17935.1, W30805.1 , H86313.1, H85644.1, H06905.1, R13668.1, T74922.1, AC036188.2, AC068190.1, AC022429.3, AL121796.4, AC021596.1, AC026129.3, AC009518.6, AC016934.4, AC026863.3, AC068174.1, AC023845.2, AC020874.2, AL356464.2, AC044882.3, AC026004.3, AC069274.1, AC069259.1, AC061981.2, AC034288.2, AC022101.3, AC022096.3, AC016602.5, AC010398.6, AC008842.4, AC008950.3, AC008687.3, AC068557.1, AC068310.1, AC009440.2, AC009309.2, AC009471.3, AC019043.3, ACOl 1711.2, AC048354.1, AC026667.2, AC025706.3, AC015999.3, AC026819.1, AC026206.1, AC024518.2, AC016750.4, AC021121.3, AC022773.2, AC02201 1.2, AC018835.3, AC007578.4, AC016394.3, AC022381.1, AC010165.2, AC019815.1, AC018014.1, AC006910.2, AL121928.11, AL157364.2, AL139000.3, AL135842.5, AL355335.3, AL139347.3, AL356461.1, AL356373.1, AL139424.3, AL157386.3, AL354956.1, AL353646.1, AP001983.1, APOOl 182.1, AP001098.2, AP000909.1, AP000877.1, AP000854.1, AP000833.1, AP000710.1 , SEQ ID NO: 318 NGO-St-141 YS1653/T3

AF220152.2, AF176646.1, AF095791.1, AB041546.1, AC009145.4, AFl 10520.1, U48455.1 , AC007686.5, AC004000.1, AC006365.3, AC005820.1, AF135125.1, AC005519.2, AC006957.1, AL049734.1 1, Z84466.1, X60322.1, AA307658.1 , AW295050.1, AW381667.1, AW654821.1, AW762888.1, AW062585.1 , AW820659.1, AI450529.1, W40612.1 ,

AW295045.1, AF150311.1, AI019873.1, U49254.1, AW451671.1, AL044797.1, C93889.1, AA215860.1, AW870886.1 , AW870865.1, AW286314.1, AI711921.1, AI695573.1, AI450513.1, AI415393.1, T46771.1, AA381620.1, AA381302.1, AA224113.1, AA036086.1, AA008214.1, AA007765.1, W41129.1, AL135793.5, AC006180.1, AC040174.2, AC027279.2, AC009451.6, AC025959.3, AC055713.2, AC048331.5, AC046170.2, AC009449.2, AC025963.2, AC016438.3, AC026894.1, AC024530.3, ACOl 1061.4, AC010844.5, ACOl 1318.8, AC068982.2, AC069010.1, AC025987.3, AC006534.3, AC068877.1, AC068837.1, AC068519.1, AC027824.2, AC068364.1, ACOl 2272.2, AC025697.2, AC026378.4, AC055858.1, AC027031.2, AC040998.1, AC032017.1, AC023034.2, AC025368.1, AC013786.2, AC019340.2, AC021315.1, AC015706.2, AL355366.2, AL139109.2, AL138749.7, SEQ ID NO: 319

NGO-St-141

YS1653/T7

AF220152.2, AF176646.1, AF095791.1, T54480.1, AA197191.1, AW103791.1, AW131855.1, AW379901.1, AW856286.1,

AW856267.1, AW8561 15.1, AW856067.1, AW815565.1 , AW815555.1, AW815535.1, AW815392.1, AW815391.1, AW582306.1, AW582296.1 , AW582282.1, AW391319.1, AW380346.1, AW362647.1, AI525534.1 , AW815543.1,

AW605996.1, AW605995.1 , AW605994.1, AW605992.1, AW605991.1 , AW605988.1, AW582313.1, AW582268.1,

AW380347.1, AW380331.1, AW380323.1 , T29399.1, W25677.1, N57107.1, AW861030.1, AW861031.1, AW753790.1 ,

AA133029.1, AW238260.1, ALl 35793.5, AL353777.6, SEQ ID NO.320 NGO-St-142 YS1703/T3 5'

NM_003920.1, AF098162.1, AB015597.1, AK000721.1, NM_011589.1 , AF098161.1, AF071506.1 , AB019001.2, AB015598.1 , AF126480.1 , AB019576.1, AC007043.3, AP000354.1, AC000105.41, ACOl 1456.2, AE003430.1,

NM_006118.1, AC007655.1, AC007541.9, AC004032.7, U20824.1 , U82696.1, AL132975.1, AL132954.1, U68566.1, AL035693.19, AL022330.4, AL034552.22, AJ248285.1, NC .001136.2, AC020912.4, AC016662.5, AC012679.3, NM_007682.1 , NM_001717.1 , AC005035.1, AC007784.7, AF135787.1, AF135397.1, AFl 35395.1 , AC007787.1, AF091398.1, AC006380.2, AC005069.2, AC006062.4, L34162.1, L19443.1, AF022365.1, U59694.1, AL049569.13, Z85996.1 , Z74369.1 , Z74368.1, Z26875.1, Z46796.1, Z95210.1, X55038.1, M26440.1 , M15410.1 , X68757.1, M19540.1, L03427.1, X82086.1, AW839959.1, W87879.1, AW672754.1, A W379444.1 , AW840009.1 , AW277013.1, AA853284.1, AW326647.1, AW658376.1, AW802270.1, AW614491.1, AW407158.1, AW343382.1, AW161333.1, AW055155.1, AI640251.1 , AI494066.1 , AI028107.1, AI017338.1, AA987779.1, AA550998.1, AA476555.1, AA378527.1, AA373491.1, AA348092.1, AA324524.1 , AA324379.1, AA321961.1, AA216551.1, AA213579.1, W82846.1, C04452.1, C03261.1, W07180.1, W04378.1, W03539.1, W02741.1, N99738.1, N40129.1, N35204.1, N28312.1, H91970.1, R91592.1, AW485342.1 , AW435759.1, AW426330.1, AW163683.1, AW013483.1, AV003759.1, AI618639.1 , AI416196.1, AI201312.1, AA561002.1, D81215.1, R25330.1, AC025574.6, AC024884.6, AC009289.5, AC009056.3, AC012534.2, AC007424.20, AC024096.7, AC022438.3, AC032035.2, AC023767.3, AC020703.3, AC024418.2, AC025107.1, AC010532.2, ACOIOI 13.4, AC014387.1, AL354980.1, AL080246.13, AL121812.1, AP001652.1, AP001636.1, AP000576.2, AC018995.4, AC023130.3, AC034245.2, AC027309.2, AC010503.5, AC010862.5, AC010533.3, AC009139.5, AC023572.3, AC022217.3, AC016168.3, AC025100.2, AC009577.3, AC021762.3, AC017022.3, AC023341.3, AC015473.3, AC024019.2, AC023579.2, AC016018.7, AC023321.1, AF200455.1, ACOl 1694.2, AL121901.18, AL136114.2, AL079336.13, AL353140.3, AL139274.6, AL160258.3, AL354822.1 , AL353779.2, AL158845.2, AL157699.2, AL121715.2, AL132640.1, AC000382.1, AL139247.1,

SEQ ID NO.321

NGO-St-142

YS1703 T7 3'

NM_003920.1, AF098162.1, AK000721.1 , AL022149.2, NM_003599.1, AC009294.8, AF064804.1, AF069734.1 , AF073930.1, AC004508.1, AL163285.2, AL163912.1, AL080243.21, M62354.1, AW136364.1, AI333322.1, AA809127.1, AW512259.1, AW167047.1, AW675811.1, AW418601.1, AI802251.1, AI283089.1, AI885862.1, AW769136.1, AW181883.1, AI969152.1, AI825472.1, AI494276.1, AW189438.1, AI278255.1, AAl 15381.1, AW731809.1 , AW275265.1, AI559688.1, AI283087.1, AA679712.1, AW089758.1, AI002252.1, AW058036.1, AI696514.1, AA853283.1, T16124.1, AI446312.1, AI468188.1, AI417732.1, AAl 15380.1, AW134955.1, AW386251.1, AW372691.1, AW372725.1 , AW386250.1, AW386246.1, AW386230.1, AW384593.1, AW373076.1 , AW386279.1, AW386226.1, AW372712.1, AW151342.1, AW749244.1 , AW372690.1, AW384617.1, AW373100.1, AW372711.1, AW386261.1, AI913828.1, AI887884.1 , AW372727.1, AW386248.1, AW386266.1, AA564588.1, AC025574.6, AC024884.6, AC012647.15, AP000938.2, AP000894.2, AC068984.3, AC025188.3, AC020927.4, AC010621.3, AC008529.3, AC022553.2, AC037440.1, AC019231.3, AC025807.2, ACOl 1035.3, AC023917.2, AC011898.2, AC017021.2, AC022999.1, ACOl 1 134.2, AL355873.2, AL161905.4, AJ011929.1,

SEQ ID N0.322

NGO-St-143 combined

AL137757.1, NM_003683.1, U79775.1, AL163297.2, AP001752.1, AP001053.1, NM_010925.1 , U79773.1, U79774.1 , AF227000.1, AF 102850.1 , AF032922.1, AF039698.1, AF103726.1, U48696.1, AF045432.1, AF027174.1, AF033097.1, AJ243486.1, S78798.1, AJ249625.1, U66300.1, U39066.1, AJ004935.1, U37573.1, Z97178.1 , AJ010903.1, Y17148.1 , U30169.1 , Z49980.1, D61704.1, AF030515.1, AF061786.1, AJ277276.1, AJ277275.1, AJ001103.1, U34048.1, AJ243655.2, U35663.1, Y15421.1, AJ277097.1, AJ243250.1 , X99051.1 , AF033565.1, AJ237664.2, S83098.1, U65376.1, U52868.1, AJ242994.1, AF079586.1, AF033096.1, AF013238.1, AL163972.1, X99055.1, X65215.1, AC007193.1, Z92546.2, AC010793.3, AF155911.1, AC005049.2, AL163299.2, AP001754.1, AB023046.1, M22135.1, AI634547.1,

AI905810.1, AI167158.1, AI860822.1, AI362799.1, AA879460.1 , AWl 93286.1, AA621964.1, AAl 13148.1, AA085786.1, AA477106.1, AA814978.1, AI905802.1, AI160620.1, AI905797.1, AA425939.1, AI368572.1, AA135482.1, T07989.1 , L25241.1, AI905807.1, AI762088.1, AI905803.1, AI905804.1, AI905811.1, AI905805.1, AI905808.1, AI905809.1, AA931669.1, AI905800.1, F36453.1, AA135818.1, H35525.1, AW743985.1, AL022772.1, AW230615.1, AA967213.1, AA240651.1, AA120481.1, AA072658.1, AI905822.1 , AW416555.1, AA755933.1, AA870102.1, AV297071.1,

AI292030.1, AA867502.1, AV267338.1, AW356977.1, AV280340.1 , W58771.1 , AA674077.1, N55721.1, AW587463.1, AA095435.1, N88018.1 , AW587505.1 , AV326909.1, AI816677.1, AI816676.1, AI816670.1, AI816665.1, AI816636.1, AI816635.1, AI816630.1, AI816629.1, AI816623.1, AI816621.1, AI816617.1, AI816615.1, AI816614.1, AI816613.1 , AI816612.1, AI816606.1, AI816605.1, AI815377.1, AI815338.1, AI815337.1, AI815336.1 , AA247964.1 , AA249353.1 , AA247827.1 , AA096046.1 , AA095641.1 , AA093577.1 , AA092086.1 , N89520.1 , N83168.1 , N88601.1 , N84855.1 , N84830.1 , N84781.1, N84718.1 , N84712.1 , N84048.1 , N83993.1 , N83992.1 , N88518.1 , AI816682.1 , AI272402.1 , AC003656.1 , AC025913.2, AC015890.2, AC010832.3, ACOl 1550.3, ACOl 1512.5, AC008738.5, AC005038.2, AC023421.2, AF216667.1 , ACO 10884.4, AC015871.1, AC019337.1, AC015860.2, AL137076.5, AC018714.3, AC022255.3, AC026513.2, AC016883.3, AC026232.1, AC021730.3, AC024123.1 , AL157896.2, AC023494.5, AC023883.4, AC026803.2, AC025224.3, AC022327.6, AC061963.1,

SEQ ID NO.323 NGO-St-143 YS1621/T3 5'

NM_003683.1, U79775.1, AL137757.1, AL163297.2, AP001752.1, AP001053.1, NM_010925.1, U79773.1, U79774.1, AF227000.1, AC007746.3, AL163972.1, ACOl 1717.4, AC007193.1, AC005988.1, AFl 11102.1, AF056324.1, AF063021.1, AL162351.1, U61731.1, Z92546.2, J02027.1, V01170.1, U35655.1, Y13901.1, X05299.1, X55039.1, AP000353.2, D87547.1, NM_002152.1, AF226868.1, AF134985.1, AF134986.1, AF227751.1 , AF227750.1 , AF227749.1, AF227748.1, AF227747.1, AF227746.1, AF227745.1, AF227744.1, AF126966.1, AF126965.1, AF190860.1, AC013482.2, AF160976.1, AF160975.1, AF124351.1, AC006917.6, AC006115.1, AC004590.1, AFOl 9380.1, AL049780.2, AL132763.1, AL049640.1, AJ246952.1, M60052.1, X15539.1, X55763.1, XI 3484.1, AJ012324.1, M62554.1, AB016287.1, AB005902.1, AB012043.1, AC010793.3, NM_004758.1, AC004744.1, AFl 55911.1, AF039571.1, AC002375.1, AC002096.1, AL163299.2, AL162507.1, U30378.1, AP001754.1, AP001067.1, AP000391.1, AI905810.1, AI905802.1, AI905797.1, AA425939.1, AI905807.1, AI905803.1, AI905804.1, AI905811.1, AI762088.1, AI905805.1, AI905808.1, AI905809.1, AI634547.1, AI905800.1, AA135818.1, AI860822.1, H35525.1, AW743985.1, AL022772.1, AW230615.1, AA967213.1, AA240651.1, AA120481.1, AA072658.1, AI905822.1, AW416555.1, AA755933.1, AA870102.1, AV297071.1, AI292030.1, AA867502.1, AV267338.1, AW356977.1, AI167158.1, AV280340.1, AW193286.1, W58771.1, AI362799.1, AA621964.1, AA931669.1, AA674077.1, AV326909.1, AA879460.1, AA814978.1, AI182664.1, AA824028.1, AA444579.1, AA421801.1, AI272402.1, AU079997.1, AA686017.1, AV258711.1, AA085786.1, AW226916.1,

AI790508.1, AU050803.1, AA109517.1, AA071831.1, H31173.1, AW793739.1, AW653294.1, AW345388.1, AU050568.1, AI317384.1, C93544.1, AA042339.1, AA346560.1, AA088667.1, AW831250.1, AW108116.1, AW106343.1, AI971787.1, AI235030.1, AI231939.1, AI136718.1, AA239586.1, Z74657.1, AW239596.1, AC003656.1, AC025913.2, AC015890.2, AC010832.3, ACOl 1550.3, ACOl 1512.5, AC008738.5, AC005038.2, AC046197.2, AC023421.2, AF216667.I, AC005289.15, AC005141.1, AL139241.4, AL121895.21, AC051652.2, AC069160.1, AC018714.3, AC026513.2, AC016883.3, AC012350.3, AC026232.1, AC021730.3, AC024123.1, AC017113.3, AL157896.2, AL031772.6, AC023494.5, AC023883.4, AC025177.3, AC008891.6, AC010001.29, AC021107.2, AC022327.6, AC061963.1, AC025086.2, AF235106.1, AC037447.1, AC021491.3, AC023327.3, AC019264.3, ACOl 1432.2, AC018802.3, AC024916.1, AC020827.2, Z95330.10, AL157877.5, AC069141.1, AC024116.10, AC068663.1, AC068438.1, AC012115.2, AC026657.3, AC046148.2, AC003059.11, AC012540.2, AC034254.1, AC032012.1, AC015705.3, AC012399.16, AC020836.1, AC020971.1, AC023174.1, AL121581.19, AL355598.3, AL133401.15, AL133317.5, AL356104.1. AL158169.1,

SEQ ID NO.324 NGO-St-143 YS1621/T73'

AL137757.1, AL163297.2, AP001752.1, AP001053.1, NM_003683.1, U79775.1, NM_003830.1, AC007633.3, AF170484.1, U71383.1, AL109953.24, AL161831.1, AL161586.2, AL161515.2, AL079347.1, U32186.1, AC006920.10, AC005560.2, AE003552.1, AE003551.1, AE003542.1, AC005774.1, AFl 70972.1, AC009895.2, AC005049.2, AF017257.1, AL163277.2, AL049795.20, AL031588.1, AL031848.11, L34771.1, U46669.1, AP001732.1, AP001040.1,

AB023046.1, AI634547.1, AI167158.1, AI860822.1, AI362799.1, AA879460.1, AW193286.1, AA621964.1, AAl 13148.1, AA085786.1, AA477106.1, AA814978.1, AI160620.1, AI368572.1, AA135482.1, T07989.1, L25241.1, AI762088.1, AA425939.1, AA931669.1, F36453.1, AA135818.1, AI155506.1, AA386906.1, Z81226.1, W89417.1, AA049595.1, AW819008.1, AW812918.1, AW812808.1, AW651237.1, AW651235.1, AW182071.1, AV367551.1, AWl 18908.1, AL12U32.1, AI760754.1, AU050523.1, AU069491.1, AI538204.1, AI301 191.1, AI204164.1, AI192033.1, AI188040.1,

AI005113.1, AI004282.1, AI001990.1, AA829448.1, AA808355.1, AA805773.1, AA805770.1, AA805757.1, AA578718.1, AA461396.1, W49126.1, N42521.1, H77382.1, H69418.1, R83544.1, AC003656.1, AC010832.3, AC069214.1, ACOl 1121.4, AC022255.3, AC019225.2, AC025865.2, AL160006.2, AC021886.4, AC025224.3, AC044866.1, AC018755.2, AC024514.2, AC006433.14, AC008764.6, AC020907.3, AC020553.3, AC023169.3, AC026279.3, AC016207.4, AC010958.3, AC026392.2, AC026226.1, AC010751.3, AC010698.4, AC010043.4, AC015977.3, AC020578.3, AC014376.1, AC014962.1, AC020215.1, AC010107.5, AC010566.2, AL121991.4, AL354000.2, AL137077.4, AL158217.3, AL035362.1, Z96802.1, AP001522.I,

SEQ ID N0.325 NGO-St-144 YS273/T3 5'

AF134726.1, AP000502.1, AF109906.1, AC004491.1, U95738.1, AC004169.3, AC004702.1 , Z97206.1 , AE003627.1, AE003462.1, AF207857.1, AF220606.1, AFl 67431.1, AF175708.1, AC007258.3, AF123049.1, AC005747.1, AC005734.1, AF065393.1, AC004642.1, AC003112.1, AL096814.26, AL031658.11, AL050342.42, AL034548.25, AL031291.3, Z98304.1, AL031055.1, AL031848.i l, X00171.1, M27063.1, Z62533.1, M83563.1, AI828004.1, AA934369.1,

AA284078.1, AI363412.1, AA825937.1, AI693027.1, AW135103.1, N32981.1, AI380588.1, AA889484.1, AW849473.1, AA281771.1 , AW452548.1 , AI056156.1 , Al 198369.1 , AA888916.1 , AA865127.1 , AW499959.1 , AI979291.1, AI570702.1 , AA768957.1, AI916722.1, AA804213.1, AA885368.1, AW489464.1, AW434474.1, W53342.1, AA822514.1, AA017911.1, AV420901.1, AV414577.1, AW297734.1, AW086516.1, AI399628.1, AI297948.1, AI294501.1, AI255938.1, AA513205.1, AA179371.1, AA145014.1 , W63826.1 , AL139040.4, AC013751.3, AC068591.1, AC018720.3, AC015940.2, AC025843.2, AC015931.4, AC015801.3, AC009558.3, AC010959.3, AC008088.2, AC018665.2, ACO 18521.1 , ALl 61638.2, AC063954.2, AC036174.2, AC068728.3, AC022420.3, AC010484.3, AC008439.3, AC032019.2, AC018644.3, AC009220.7, ACOl 1443.4, AC031998.2, AC022285.5, AC062029.1 , AC026591.2, AC022227.6, AC025707.3, AC040955.1, AC026154.3, AC025931.2, AC013345.3, AC013328.5, AC015670.4, AC015988.3, AC025590.2, AC026471.1, AC020560.2, AC020706.3, ACOl 1 165.3, ACOl 1798.3, AC023022.1, AC012489.3, AF214634.1, AC020183.1, AC020509.1 , AC009849.6, AC005124.2, AL356464.1, AL122034.8, AL353092.3, AL162255.5, AL121747.21, AL355314.1, AL354714.2, AL158217.3, AP001491.1, SEQ ID NO.326 NGO-St-144 YS273 T7 3'

AF134726.1, AP000502.1, AC003037.1, AC002040.1 , AC006449.19, AC002044.1, AC004129.1, AC006441.13, AC002351.1, AF030876.1 , AC005757.1 , AC005620.1 , AC004583.1 , AF031078.1 , AF223391.1, U96629.1 , AC009516.19, AC005921.3, AP001052.1, AP000553.1, L48038.2, AC002059.3, AC000026.3, AF121781.1, AL163279.2, AC002326.1, AL009031.1, AC007956.5, AC006387.3, AC004098.1 , AL133355.12, AC002456.1, AC005015.2, AC005519.2, AP000184.1, AP000040.1 , AP000282.1, AP000108.1, U91321.1, AC003959.1 , AL163215.2, AL135749.2, AD000864.1, L78810.1, Z93023.1, AL009172.1, AP001670.1, AC004668.1, AC003086.1, AC004465.1, AC004132.1 , AC003684.1 , AL121749.13, AC005067.2, AL035045.2, AC005057.2, AC004687.1, U62293.1, AF196971.1 , AC006544.19, AC004382.1, AC006254.10, AL050307.13, Z86064.1, Z97054.1 , AL031276.1, AL109798.19, AP000283.1, AC002126.1, AC003010.1, AL031848.11, Y07848.1, AC00611 1.2, U82828.1, AL023584.1, AF038458.1 , U93037.1, AL031311.1, ACOl 1455.6, AC005295.1, AC005104.1, AC004253.1, AL121809.4, AC006930.1 , ALl 36418.2, AL139054.1, AL078644.10, AL022237.1, AA284189.1, AW338381.1, AA568535.1, AA579064.1, AA281850.1, AA994641.1, AW794982.1, AA857326.1, AL036622.1, N89207.1, AW591633.1, AW166629.1, AW088364.1, AI076062.1, AA748058.1, AA704850.1, AA570496.1, AA371011.1, AA044796.1, AA044741.1, M77904.1, AW081071.1, AI631359.1, AI580045.1, AI471805.1, AI469586.1, AI282705.1, AA854983.1, AA644545.1, AA503615.1 , AA486925.1, AW875776.1 , AW794828.1 , AWl 93880.1 , AI242847.1 , AI085078.1 , AI032984.1 , AA812987.1 , AA745404.1 , AA482685.1 , AA460896.1, AA377927.1, AA174138.1, AA059338.1 , W01949.1, N21 11 1.1, AW409692.1 , AI051697.1, AA974475.1, AA579437.1, AA580000.1 , AA564343.1, AA465689.1, AA338281.1, AW518364.1, AW373785.1, AWl 35699.1, AI798136.1, AI6961 17.1, AI475231.1, AI339498.1 , AI168274.1, AI025850.1, AI017159.1, AA657377.1 , AA614340.1, AA557393.1, AA525157.1, AA504723.1, N31583.1, N21688.1, T52837.1, AA507035.1, AA317869.1, AI223321.1, AA742637.1 , H73550.1, T90362.1 , H60462.1, H50970.1, AI679747.1, AI332671.1, AI014798.1, AW855113.1, AW086361.1, AI862231.1, AI792627.1, AI792525.1, AI349662.1, AI348722.1, AI254439.1, AI053903.1, AI053450.1, AA594091.1, AI469598.1, AW105737.1, AA830169.1, AW316747.1, AW836527.1, AA826285.1, AL139040.4, AL356352.2, AC067952.3, AL096887.7, AL160175.4, AC015904.3, AC016636.4, ACOl 1461.2, AC009019.4, AC008732.4, AC024156.2, AC022037.1, AP000921.2, AP000571.1, AC008267.3, AC018506.3, AC016289.3, AL353653.5, AL354681.1, AC015551.9, AC023121.3, AC023970.2, AC027272.2, ACOl 1 152.4, AC011 134.2, AC016703.3, AP000761.1, AP000685.1, AC008731.4, AC019207.3, AC017093.2, AL354656.1, AP001381.1, AC055815.2, AC026419.2, ACOl 1495.3, AL162415.2, AC021836.3, AC018500.2, AL353712.2, AL158I69.1, AL138798.2, AC021590.3, AC013691.3, AC012364.3, AC021565.1, AC008922.5, AC016916.4, AC021194.2, AC046135.4, AL159989.3, AL161672.2, AL138788.1, AC025164.7, AC064826.2, AC016675.4, AC009362.5, ACOl 1477.3, AC009073.5, AC027372.2, AC023959.2, AC012182.3, AL139226.14, AC046176.2, AC016736.3, AL136360.7, AC010742.3, AC013797.2, AL109743.3, ACOl 1484.2, AC026170.1, AC012433.5, AC026022.2, ACOl 1499.2, AC032015.2, AC026300.2, AC026634.2, AC009335.2, AC022951.2, AL355001.3, AL137849.2, AC044819.2, AC020757.2, AL121926.16, AL354693.1, AC025918.3, AC012659.3, ACOl 1785.3, AL160009.3,

AL139022.1, AC007939.2, AL354745.3, AL139132.4, AL354808.3, AJ132411.1, AC044817.2, AC025090.2, AC013275.4, AP000668.1, AC0091 10.5, Z83844.5, AL031672.12, AL033376.17, AC002045.1, AC005377.2, AC006509.15, AC005071.2, AC005940.3, AC007029.3, AL050350.14, AC004506.1, Z82206.1, SEQ ID NO.327 NGO-St-145 YS1411/T3 5'

AL133161.1, AK001729.1, AC002301.1, AC005343.1, AC003669.1 , Z50797.1, AC006991.2, AE003795.1 , AC012302.5, AC009947.2, AC000065.1, NM_008448.1, AC005998.3, AC005275.1, AC004311.1, AC005771.1, U40856.1, AC004505.1, AF069716.1, AF039716.1, AL161496.2, U86090.1, Z82190.1, Z70273.1, Z94056.1, AJ248283.1, U29523.1, X81852.I , AP000067.1, Ml 1797.1, L27153.1 , AL047720.2, AW815677.1, AW668623.1, AI307523.1, AW786510.1, AI426794.1, AI729581.1, AA460639.1 , AW312313.1, AI793025.1, AI792241.1, AI765078.1, AA914152.1, AW729381.1, AW469634.1, AU082430.1, AU082418.1, AV362112.1 , AV327711.1, AI894213.1, AI892798.1, AI812413.1, AV149849.1, AI682199.1 , AI649596.1, AI293042.1, AI190544.1, AI135558.1, AU017449.1, AU017158.1 , AI014546.1, C86411.1, AA71 1482.1, AA692780.1 , AA692302.1 , AA671345.1, AA655714.1, C56496.1, AA415524.1, AA097087.1, AA087538.1, AA087381.1 , H33004.1, AL353736.1, AC012445.3, AC009133.5, AC023831.3, AL139284.3, AC068045.1, AC017108.2, AC010746.3, AL355577.2, AL161891.6, AL160394.4, AL121939.3,

SEQ ID NO.328 NGO-St-145 YS1411/T7 3'

AL133161.1, AK001729.1, AF087969.1, AF177478.1, AL159179.2, AL049835.3, AL096851.1 , AC007252.2, AF081241.1, AC008125.9, AF135183.1 , AC004704.2, AC005937.1, AC003024.1 , U71587.1, AE000904.1, AJ271161.1, U43282.1, U41530.1, AB042823.1, AP000511.1 , AB023048.1, AJ007958.1 , AL043584.1 , AI131 161.1, AL047721.1, AI074999.1, AI369743.1, AI191659.1 , AI752102.1, AI804688.1, H70039.1, W63623.1, AA412273.1, AA345937.1 , AA461564.1, AA34601 1.1, W39608.1, AA046569.1, AL045395.1, AA412608.1, H70038.1, AW263032.1 , AA534737.1, AI854609.1, AU024381.1, AI235913.1, AW556867.1, AI464166.1, AI862154.1, AW195190.1 , AW532431.1 , AW134839.1 , AI632675.1 , AI333447.1, AW070552.1, AA776248.1, AI033598.1 , AI492046.1, AI560827.1, AI990263.1, AI090658.1, AW131196.1, AI337152.1, AA962117.1, AA216415.1, AI377836.1, AI032741.1, AI381470.1 , AW182779.1, AA137689.1, AA865536.1, AA632347.1, W61524.1, AI307523.1, W88673.1 , AI278969.1 , H30866.1, AA460639.1, AW336387.1, R94150.1, AW499467.1, AA294458.1 , AI401456.1, AA432615.1, AV390623.1, AW580849.1, AW580825.1, AW336569.1 , AW336391.1 , AW257455.1, AW217194.1, AV264232.1 , AI439888.1, N53539.1, AL353736.1, AC010736.4, AC023254.3, AC061993.2, AC024232.2, AC025734.2, AL139125.3, AL158046.1 ,

SEQ ID NO.329

NGO-St-145

YS144/T3 5'

AL133161.1, AK001729.1, AC005343.1, Z50797.1, NC_001142.1, AE003727.1, AE003462.1, AF223391.1 , AC004662.1, AC004254.1, AC006820.1, AC024205.1, NM_007046.1, NM_006521.1, AF162780.1, NM_008448.1, AF207550.1 ,

AF196779.1, AF088916.1, AC005275.1, AF049895.1, AEOOOl 13.1, AF068862.1, AC003694.1, AF070717.1, AF069716.1 , AC004642.1, L43549.1 , AL163239.2, AL133332.12, AL161985.1, AL161496.2, U86090.1, AL050138.1, Z70273.1, U29523.1, Z49452.1, D87675.1, AP001694.1, X97162.1, X96717.1, X51330.1, AP001443.1, AP000140.1, ABOl 1100.2, AP000088.1, X54945.1, D10483.1, L27153.1, AL045394.1, AL047720.2, AW815677.1, AW447609.1, AW418275.1, AI426794.1, AW668623.1, AA087606.1, AI380050.1, AA914152.1, AW774428.1 , AW736393.1, AW649599.1, AW586591.1, AL138309.1, AI892798.1, AI739806.1, AA71 1482.1, AA692780.1, AA692302.1, AA671345.1 , AA655714.1, AA415524.1, AAl 19710.1, AA097087.1, AA087538.1, AA087381.1, H33004.1, R50279.1, AL353736.1, AC012445.3, ACOl 1030.4, AC009564.4, AC051613.3, AL132672.7, AP000478.2, SEQ ID NO.330 NGO-St-145 YS144 T7 3'

AL133161.1, AK001729.1, AF087969.1, AF177478.1, AL159179.2, AL049835.3, AC006222.1 , AC007252.2, AF081241.1, AC008125.9, AF135183.1, AC004704.2, AC005937.I, AC005180.1, U71587.1, AE000904.1, AJ271161.1, U43282.1, U41530.1, AB042823.1 , AP000511.1, AB023048.1, AL043584.1 , AI131 161.1, AL047721.1, AI074999.1, AI369743.1, AI191659.1, AI752102.1, AI804688.1, W63623.1 , H70039.1, AA412273.1, AA345937.1, AA461564.1, W39608.1, AA346011.1, AA046569.1, AL045395.1 , AA412608.1, H70038.1, AW263032.1, AA534737.1, AI854609.1, AU024381.1, AI235913.1 , AI464166.1, AW556867.1, AI862154.1, AW195190.1, AW532431.1 , AW134839.1, AI632675.1, AI333447.1, AW070552.1, AA776248.1, AI033598.1, AI492046.1, AI560827.1, AI307523.1 , AI990263.1, AI090658.1, AW131 196.1, AI337152.1, AA962117.1, AA216415.1, AI377836.1, AI032741.1, AI381470.1, AW182779.1, AA865536.1, AA137689.I , AA632347.1, W61524.1, AA460639.1, W88673.1, AI278969.1, H30866.1 , AW336387.1, R94150.1, AA432615.1, AW499467.1, AA294458.1, AV390623.1, AI598316.1, AI401456.1, AW706903.1, AW580849.1, AW580825.1, AW257455.1, AW217194.1, AV264232.1, AI950381.1, W28723.1, N53539.1, H60201.1, H60196.1, R45124.1, R19599.1, R19570.1 , AL353736.1, AC010736.4, AC023254.3, AC061993.2, AC021751.11, ACOl 1448.2, AC025792.2, AC025734.2, AC023932.2, AL139125.3, AL158046.1, APOOl 127.1,

SEQ ID NO.331 NGO-St-145 YS278/T3 5' AL133161.1 , AK001729.1, NM_008958.1, AB028866.1, AB010833.1, NM_014726.1, AF217796.1, AC002432.1,

AC002303.1, AF077302.2, AC007298.17, AC005520.2, AFl 12866.1, U60822.1, AC0O4233.1 , AL135752.2, AJ131018.1, AL096699.1 1, U10895.1 , AK001621.1, AB018318.1, AW500657.1, AW673603.1, AW868998.1 , AW869117.1, AI608224.1 , AA387916.1, AW288019.2, AW654284.1, AW493485.1, AW487305.1, AW487276.1, AW461989.1, AW437659.1, AW403475.1, AW319454.1, AW239228.1, AW239051.1 , AV217284.1, AV215050.1, AV205793.1, AV155082.1, AV166903.1, AV152358.1, AV137501.1, AV123651.1, AV120391.1 , AVI 17483.1 , AV101080.1, AV098121.1, AV091752.I , AV084455.1, AV083583.1, AI763878.1, AV061031.1, AV060485.1, AV058197.1, AV057140.1 , AV056958.1, AV055574.1, AI713124.1, AV006753.1, AI575485.1, AI527477.1, AI012556.1, AH 79780.1, AI175786.1, AH 19288.1, AH 12286.1 , AH 11977.1, All 1 1490.1, AI072849.1, AI071746.1 , AA874227.1. AA810909.1, AA797102.1, AA616728.1 , AA445862.1, A A278495.1, AAl 82075.1, AA145911.1, AA072792.1 , AA059888.1, AA047908.1, AA041963.1, AA032369.1, AA003397.1, H61508.1, AL353736.1, AC012683.3, AC023955.2, AC018698.4, AC047322.1, AC049120.1, AC025999.3, AC019264.3, AC025655.2, AC010754.2, AL160235.1, AP001202.1, AC021048.8, AC024727.4, AC068810.1, AC025643.3, AC068488.1, AC019093.3, AC022842.4, AC023593.3, AC010268.3, AC019129.3, AC018673.3, AC025424.3, AC027044.2, AC021421.2, AC024731.5, AC013543.4, AC036147.1 , AC024883.3, AC027777.1, AC021323.2, AC025133.2, AC020994.5, AC023658.1, AC016777.3, AF202962.1, AC013679.1 , AC005054.1, AL162714.4, AL121845.18, AL121880.15, AP001556.1 , AP001368.1, AP000834.1 , AP000757.1 , AP000683.1 ,

SEQ ID N0.332 NGO-St-145 YS278 T7 3'

AF087969.1, AL133161.1, AK001729.1, AF177478.1, AL159179.2, AL049835.3, U40830.1, Z97055.1 , AJ238394.1, X61677.1 , M90087.1, AC004981.1, AF08124I .1, AF135183.1, AC004704.2, AF064857.1 , AL163281.2, AJ271 161.1 , Z82077.1, U43282.1, U41530.1, X89886.1 , AB042823.1, AL045395.1, AW263032.1, AA534737.1, AI862154.1, AW195190.1, AI333447.1, AW070552.1, AI632675.1, AI492046.1, AI033598.1, AA776248.1, AI560827.1, AI090658.1, AI990263.1, AI337152.1, AW131 196.1, AI377836.1, AI381470.1, AI032741.1, AA216415.1, AW182779.1 , AA046569.1, W63623.1, AA632347.1 , AI278969.1 , AA865536.1, AI401456.1, AI439888.1 , W88673.1, AW028469.1, AA810290.1, AL047721.1, AA725456.1, AI074999.1, AI752102.1 , AI191659.1, AI 131161.1, AA412273.1, AI369743.1, AI699071.1₎ AI804688.1, AA461564.1, AW611821.1, AW083337.1, AL043584.1, AA620499.1, H70039.1, H27907.1, AI991681.1, W15240.1, AI684348.1, AI424392.1, AA22951 1.1, AA345937.1 , AA046704.1, AA34601 1.1, AI608926.1, AI492935.1, AA447104.1, AI235913.1, AU024381.1, AI854609.1, AI464166.1, AW556867.1, AW532431.1, AW134839.1, AW747938.1, AA962117.1, AA557671.1, AA137689.1, W61524.1, AA972005.1, W39608.1 , H30866.1, H70038.1 , AW336387.1, R94150.1, AW499467.1, AA294458.1, BB000336.1, AW580849.1, AW580825.1, AW257455.1, AW217194.1, AV315168.1, AV274485.1, AV264232.1 , AW 152551.1, AV046353.2, AI503741.1, C99210.1 , AA795526.1, C79929.1, AA607081.1, AA508474.1, AA248433.1, N53539.1, R29422.1, AL353736.1, AC010736.4, AL356241.2, AC061993.2, AC032025.2, AC027704.2, AC013712.3, AC022868.4, AC025734.2, AL139231.4, AL139125.3, AL158046.1, AC015551.9, AC062004.2, AC024895.5, AC023757.4, AC068652.1, AC044787.3, AC016567.4, AC009220.7, AC021091.2, AC009061.8, AC032021.2, AC068066.1, AC023041.2, AC009994.4, AC027480.2, AC009551.4, AC062039.1, AC027682.2, AC019243.3, AC024974.2, AC019214.2, AC012429.4, AC023264.2, AC018689.2, AC012594.3, ACOl 1138.2, AC012050.1, AL356242.2, AL356100.1, AL157905.2, AL022597.5, AP001910.1 , AP001260.1, AP001093.2, AP000743.1, Z92865.1,

SEQ ID NO.333 NGO-St-146 YS358/T3 5'

AC006038.2, NM_004434.1, U97018.1 , AC002094.1, NM H3589.1 , AC018632.1, AC005881.3, AC007887.8, AF128394.1, AC006121.1, AL163203.2, AF004874.1, AL139078.2, AL050302.2, AL049911.2, U14611.1, AB019224.1, AB026642.1, X15122.1, Y00398.1, X02806.1, D00216.1 , K02646.1, AE003844.1, AC004901.1, AF125520.1, AF017299.1, Z54281.1, Z68217.1, AL035562.14, U40426.1, AK000952.1, Z81167.1, AW851 191.1, AW851190.1 , AW342912.1, AW306072.1, AL041588.1, AW683786.1, AW483175.1 , AW471804.1, AW471754.1, AW433049.1, AW397869.1, AW397864.1, AW397818.1, AW397808.1 , AW397328.1, AW397299.1, AW397225.1, AW397183.1, AW397082.1 , AW396931.1, AW396867.1, AW395710.1, AW395684.1, AW395670.1, AW318300.1, AW318207.1, AW318175.1, AW318001.1, AW317912.1, AW317798.1, AW317683.1, AI941128.1, AI941087.1, AI940932.1, AI940896.1 , AI795036.1, AI748210.1, AI735897.1 , AI735879.1, AI735805.1, AI735804.1, AI736030.1, AI629905.1, AU024702.1, AU024209.1, AA766572.1, AA760753.1, AA501257.1, AA501255.1, T08982.1, AC013322.5, AL133368.1 , AC025644.2, AC021799.1, AC013567.2, AL138963.4, AL138693.6, AC027399.2, AC007445.2, AC016201.5, AC022035.2, AC017091.3, AF215845.1, AP001402.1, AC036149.2, AC025524.2, AC021486.3, AC019188.3, AL355301.3, AL158201.7, AL158031.4, SEQ ID N0.334 NGO-St-146 YS358/T7 3'

AC006038.2, AF131753.1, Z82268.1, Z94721.1, AC002074.1, AC006377.3, AL161532.2, AL049500.1, AFl 14156.1, AE003579.1 , AC004111.1 , AC006040.2, AC005075.2, AF125448.1, AC005149.1, AC002416.1 , AF006762.1, ALl 17694.3, AC005826.1, AC006956.15, AC004668.1, AC015445.3, AC004862.1 , AC006379.2, AL163232.2, U56964.1 , AL035634.7, U40410.1, AB022157.1, AP001687.1, APOOl 253.1, X83624.1, AC007590.1 , AF070718.1, AL161536.2, ALl 10482.1 , J04485.1, AL080250.11, AL031677.5, AL031599.1, AL049487.1, AL049656.1 , U41545.1, AW173156.1, AW419091.1, AI240374.1, AI806503.1, AW152350.1, AW276130.1, AA449115.1 , AW516027.1, AI290977.1, AI803121.1, AH92373.1, AH93573.1, AA587244.1, AI288196.1, AA977076.1, AI367149.1, AA421771.1, AI910966.1, AI343706.1, AI499018.1, AA927517.1 , AW445056.1 , AI130998.1, AW771159.1, AW592377.1, AI097006.1 , AI864290.1 , AI097567.1 , AI884377.1 , N94895.1, AW51 1972.1, AI305161.1 , AI304601.1 , AW079658.1 , AW044403.1, AW768529.1, AW151869.1, AA193343.1, AI341554.1, AI290345.1, AA193461.1, AA861909.1 , AA527518.1, N29071.1, AI277874.1, AI027217.1, AA459958.1, AA716610.1, AI051389.1, AA836942.1, AA679242.1, AA553698.1, AA082407.1 , AI873933.1, R38955.1, AW272553.1 , AA865858.1, AA832468.1, AA417893.1, N27375.1, Dl 1610.1, AI867049.1, AA917795.1, AA256313.1, AA034164.1, N48340.1, H10359.1, AWl 19101.1, AA256438.1, N23618.1, AI240601.1 , AA514495.1, AI290297.1, AI061272.1, AA443213.1, AA789034.1, H08100.1, R40145.1, D12463.1 , AA482526.1, AI240093.1, AA493130.1 , AA122021.1 , AA994372.1, AW514004.1, AI523990.1, R84780.1 , AA227683.1, H06663.1, X91713.1, AA062803.1, AA5851 19.1, AA890144.1 , AI283724.1, AA056271.1, AI634524.1, AI644019.1, AW556280.1 , AW142557.1, AW550088.1, AC013322.5, AL355365.2, AL354880.3, AP000621.1, AC027141.1, AL133458.12, Z93243.1, Z83124.1 , ACOl 2022.5, AC068296.4, AC066601.1 , AC007481.2, AC016775.4, ACOl 5473.3, ACOl 9993.1 , ALl 57955.1 , AC067723.2, AC025164.7, AC027301.3, AC007683.3, AC026087.3, AC015625.3, AL355542.2, AL136301.4, AP001965.1, AC016255.8, AC055821.2, AC058803.1 , AC026233.2, AC024181.2, AC022087.3, AC022796.3, AC006280.6, ACOl 8594.3, AC016255.7, AL138823.3, AL096784.2,

SEQ ID N0.335

NGO-St-146

YS112/T3 5'

AC006038.2, NM H2155.1, AF103939.1, AL096717.1 , NM_004434.1, U97018.1, AE003673.1, AE001573.1, AC001655.1, NM_008519.1, NM_006007.1, AF077673.1, AF062072.1 , AFl 10104.1, AC006121.1, AF044030.1,

AF062347.1 , AF062346.1, AC003029.1, AC004226.1, U14611.1 , D84515.1, AE003596.1 , AC005191.1, AC007077.2, AFOl 7299.1, Z9681 1.2, AL035562.14, U40455.1, AA983842.1, Z81 167.1, AA681706.1, AI596558.1, AA465739.1 , AA850758.1, AW593841.1 , AW516768.1, AW475067.1, AW303490.1, AW188604.1, AI807190.1, AI767422.1, AI740707.1, AI739199.1, AI582285.1, AI473581.1, AI458952.1 , AI376302.1, AI312515.1, AA775264.1, AA743080.1, AA428244.1, AA352385.1, AA043549.1, AW637997.1, AW631275.1, AW630845.1, AW483175.1, AW361213.1, AL134742.1, AA410201.1, AA298178.1, AA298197.1, AA233347.1, AA228021.1, AA165101.1, AA035737.1 , AA002175.1 , W73050.1 , N28928.1 , D56390.1 , D58486.1 , H04632.1 , R56367.1 , R33003.1 , R24775.1 , F05590.1 , T30904.1 , Z42327.1, AW608299.1, AI903729.1, AV135789.1, AI629905.1, AU024209.1, AA648943.1, AA53231 1.1, T50574.1, AC013322.5, ACOl 1480.2, AL049868.12, AL133368.1, AC022275.9, AC020282.1, AC063945.3, AC068051.2, AC068642.2, AC062020.2, AC067870.1 , AC024948.2, AC007445.2, AC020684.4, AC022986.3, AC021885.3, AC018864.4, AC022451.1, AF215845.1, AL160266.6, AL135924.10, AC068130.2, AC069220.1, AC046133.3, AC068545.2, AC055837.2, AC036149.2, AC026720.3, AC010477.6, AC008384.4, AC008562.3, AC064860.2, AC027581.2, AC012213.3, AC016881.4, AC006400.6, AC009609.5, AC036233.1 , AC025370.2, AC025090.2, AC021463.2, AC022247.2, AC016169.3, AC016690.4, AC021877.4, AC013638.3, AC010940.3, AC015567.3, AC019239.3, AC007873.4, AC008086.2, AC019047.2, AC024171.1 , ACOl 1997.3, AC013885.1, AC013401.1 , AC015691.1, AC012116.1, AC000016.1, AL121952.6, AL355498.2, AL158210.6, AL158043.4, AL136992.18, AP001554.1, AP001484.1, AP001375.1 , AP000834.1, AP000757.1,

SEQ ID N0.336 NGO-St-146 YS1 12/T7 3'

AC006038.2, AFl 31753.1 , Z82268.1 , ALl 61532.2, AL049500.1 , AFl 14156.1 , AE003579.1 , AC0041 11.1, AC006040.2, AC005075.2, AF125448.1, AC005149.1, AC002416.1, AF006762.1, AC005826.1, AC006956.15, AC004668.1, AC002074.1, AC015445.3, AC005344.1 , ALl 63232.2, U56964.1, Z68296.1, AL035634.7, U40410.1, AB022157.1, AP001687.1, AP001253.1, X83624.1, AC004554.1, ALl 10482.1, AL133279.2, AL122021.3, AC0001 18.1, AL031677.5, AL009047.1, AL049487.1, AW173156.1, AW276130.1, AW419091.1, AI806503.1, AW152350.1, AA4491 15.1, AI240374.1 , AW516027.1, AI290977.1, AI193573.1, AI803121.1, AI192373.1, AA587244.1, AI288196.1, AI367149.1, AA977076.1, AI910966.1, AI499018.1, AA421771.1, AW445056.1, AI343706.1, AA927517.1, AI130998.1, N29071.1, AI097567.1, AW592377.1 , AW771159.1, AW079658.1, AI864290.1, AI304601.1, AI097006.1, AW044403.1, AI305161.1, AW511972.1, AI884377.1. N94895.1, AW768529.1, AW151869.1, AA193343.1, AA193461.1, AI290345.1, AI341554.1, AA527518.1 , AI277874.1 , AA861909.1 , AI027217.1 , AI051389.1 , AA459958.1 , AA716610.1 , AA836942.1 , AA082407.1 , AA679242.1 , R38955.1, AA865858.1, AA553698.1, AA256438.1, AI873933.1, AW272553.1, AA832468.1, AA417893.1, AI867049.1, AA482526.1, AA256313.1, AA034164.1, N27375.1 , D11610.1, AA917795.1, AWl 19101.1, N48340.1, H10359.1 , AI240601.1 , AI290297.1 , AA514495.1 , N23618.1 , AA789034.1 , H08100.1 , AI061272.1 , AA443213.1 , R40145.1, D12463.1, AI240093.1, AA493130.1, AA227683.I , AA122021.1 , AW514004.1, AA994372.1, AI523990.1, R84780.1, AI634524.1, H06663.1, X91713.1, AA062803.1, AA585119.1, AI283724.1, AA890144.1, AA056271.1, AI644019.1 , AW556280.1, AW142557.1, AW550088.1, AC013322.5, AL355365.2, AL354880.3, AP000621.1, Z93243.1, Z83124.1, AC027141.1, AC012022.5, AC068296.4, AC007481.2, AC015473.3, AC019993.1, AC006876.1 , AC067723.2, AC025164.7, AC027301.3, AC007683.3, AP001965.1 , AC016255.8, AC055821.2, AC025920.8, AC024162.2, AC058803.1, AC026233.2, AC018555.3, AC021381.3, AC024181.2, AC022087.3, AC022796.3, AC006280.6, AC019111.3, AC016255.7, AC012410.2, AC012105.1, AL049184.5, AL096784.2,

SEQ ID N0.337 NGO-St-146 YS266/T3 5'

AC006038.2, NM_004434.1, U97018.1, AC002094.1, NM_013589.1 , AC018632.1, AC005881.3, AC007887.8, AF128394.1 , AL163203.2, AF004874.1, AL161498.2, AL139078.2, AL050302.2, AL049911.2, AB019224.1, AB026642.1, X15122.1, Y00398.1, X02806.1, D00216.1, K02646.1, AE003844.1, AE003524.1, AC004901.1, AF125520.1 , AC006121.1, AL079352.3, Z54281.1, Z68217.1, AL035562.14, U40426.1, AW851191.1, AW851190.1, Z81167.1, AW851162.1 , AW504697.1, AW342912.1, AW306072.1 , AL041588.1 , AW683786.1, AW471804.1, AW471754.1, AW433049.1, AW397869.1, AW397864.1, AW397818.1, AW397808.1, AW397328.1, AW397299.1, AW397225.1, AW397183.1, AW397082.1 , AW396931.1, AW396867.1 , AW395710.1 , AW395684.1, AW395670.1, AW318300.1, AW318207.1, AW318175.1, AW318001.1, AW317912.1, AW317798.1, AW317683.1, AI941128.1, AI941087.1, AI940932.1 , AI940896.1 , AI795036.1, AI748210.1, AI735897.1, AI735879.1 , AI735805.1, AI735804.1, AI736030.1, AU024702.1, AU024209.1, AA766572.1, AA760753.1 , AA501257.1, AA501255.1, T08982.1, AC013322.5, AL133368.1, AC025644.2, AC021799.1, AC013567.2, AL138963.4, AC022275.9, AC027399.2, AC026927.2, AC023790.5, AC067752.2, AC007445.2, AC022035.2, AF215845.1 , AC017592.1, AC013559.2, AP001402.1, AC069220.1, AC036149.2, AC025524.2, AC024288.2, AL355301.3, AL158201.7, AL158031.4,

SEQ ID NO.338

NGO-St-146

YS266/T7 3'

AC006038.2, AF131753.1, AC004531.1, AF114156.1 , AE003579.1 , AC004111.1, AC006040.2, AF125448.1 , AC005149.1, AC002416.1, AF006762.1, AC006956.15, AF222718.1, AC015445.3, U23516.2, AC003035.1, AC004470.1, AC002070.1, U56964.1, Z66495.1, Z68296.1, AL035634.7, U40410.1, U29376.1, AB022157.1 , X83624.1 , AC016972.5, AC005075.2, AC007590.1, AF096373.1, AL161516.2, ALl 10482.1, AL031677.5, AL031599.1, AL049487.1 , U41545.1, AW173156.1, AW276130.1, AI806503.1, AW419091.1, AW152350.1, AI240374.1, AA4491 15.1, AW516027.1, AI290977.1, AI193573.1, AI803121.1, AI192373.I, AA587244.1 , AI288196.1, AA977076.1, AI367149.1, AI910966.1, AI499018.1, AA421771.1, AW445056.1, AI343706.1, AA927517.1 , All 30998.1, AI097567.1, AW771 159.1, N29071.1, AW592377.1 , AI864290.1 , AI304601.1 , AI097006.1 , AW51 1972.1 , AW044403.1 , AI884377.1 , AI305161.1, N94895.1 , AW768529.1 , AW079658.1, AW151869.1, AA193343.1 , AI341554.1, AA193461.1, AI290345.1, AA527518.1, AI277874.1, AA861909.1, AI027217.1, AI051389.1, AA459958.1, AA716610.1, AA836942.1, AA679242.1, AA082407.1, AA256438.1, R38955.1, AA865858.1, AA553698.1, AI873933.1, AW272553.1, AA482526.1 , AA832468.1, AA417893.1, AI867049.1, Dl 1610.1, AA256313.1, AA034164.1, N27375.1, AW119101.1, AA917795.1, N48340.1, H10359.1, AI290297.1 , AI240601.1 , N23618.1, AA514495.1, AA789034.1, H08100.1 , AI061272.1 , AA443213.1, R40145.1, D12463.1, AI240093.1, AA493130.1, AA122021.1, AW514004.1, AA994372.1 , AA227683.1, AI523990.1, R84780.1, AI634524.1, H06663.1 , X91713.1, AA062803.1, AA585119.1, AI283724.1, W19574.1 , AA890144.1, AA056271.1 , AI644019.1 , AW556280.1, AW142557.1, AC013322.5, AL355365.2, AL354880.3, AP000621.1, AC020978.3, AP000725.1, AC012022.5, AC068296.4, AC007481.2, AC016775.4, AC015473.3, AC019993.1, AC006876.1, ALl 57955.1 , AC067723.2, AC025164.7, AC021193.3, AC008847.3, ACOl 1672.3, AC024615.1, AC018846.1, AC016006.1, AL355587.3, AL139330.5, AP001965.1, APOOl 870.1 , AC068765.2, AC064877.1, AC026233.2, AC022087.3, AC022796.3, AC019111.3, AC018853.3, AC023261.2, ACOl 1577.3, AL049184.5, SEQ ID NO.339 NGO-St-147 YS012/T3 5'

AC008122.15, AJ001006.1, AK001469.1, AL139317.2, AC005048.2, AB019225.1, AC006577.2, AL133475.14, AC004665.2, AE003608.1, AE003528.1, AE003502.1 , AE003481.1 , AE003040.1, AC004541.1, AC002433.1, AC006370.2, AC005820.1, AC007970.3, AF106702.1, AC005209.1, AJ25141 1.1, AJ251407.1, AJ251405.1, Z81077.1, ALl 10505.3, U00484.1, AB006700.1, X55902.1, X99260.1, Ul 0402.1, M33496.1, AI470259.1, AA269728.1 , AA165912.1, AA574026.1, AW823761.1, C88768.1, AU040593.1, AA437608.1, AU043208.1, AA138266.1, AWl 23976.1 , Al 117993.1 , AA413583.1 , AA511047.1 , AV040202.2, AI632462.1 , AV068478.1 , AV051231.1 , AVI 13738.1, AA570941.1, AA516855.1 , AW636925.1 , AA591652.1, AV051161.1, AL043808.1, AL043785.1, T52030.1, AV140546.1 , AV254998.1, AW159747.1, AV0035O4.1, AW874810.1, AW874808.1, AW350719.1, AW349722.1, AW266183.1, AW265812.1, AV383092.1, AW053464.1, AI946267.1 , AVI 26934.1, AV054231.1, AI513554.1, AI308193.1 , AI307218.1, AI302479.1, AA933435.1, AA749496.1, AA681005.1, AA484958.1, AC027238.2, ACOl 1626.2, AC009901.3, ACOl 1050.4, AC067959.3, AC012591.4, AC010872.4, AC067717.5, AC025613.9, AC068958.1, AC048371.2, AC020933.4, AC020919.4, AC012619.5, AC008110.2, AC009658.5, AC025916.2, AC044804.1, ACOl 1851.3, AL121986.3, AL132875.10, AL139136.3, AL159162.3, AL121949.4, AC063926.3, AC037443.2, AC069046.1, AC061958.4, ACOl 1400.4, AC009552.4, AC008157.2, AC061969.1, AC016005.4, AC021 150.5, AC026045.3, AC032043.1, AC026225.2, AC023789.5, ACOl 1259.3, AC022535.2, AC026403.1, AC009206.19, AC021236.3, AC022646.3, AC016130.13, AC013624.4, AC010920.10, AC010846. i l, AC010575.3, AC010714.3, AC016020.4, AC022892.1, AC014418.1, AC014941.1, AC015401.1, AC020227.1 , ACOl 0039.3, AC009409.1, AC008233.2, AC005861.2, AL035662.50, AL356157.3, AL356243.1, AL133383.6, AL356074.1, AL160057.4, AL138745.2, AL158049.2, AL139044.2,

SEQ ID NO.340 NGO-St-147 YS012/T7 3'

AL139317.2, AK001469.1, AC008122.15, AJ001006.1, AC009410.3, L12018.1, U83433.1, Z74022.1, AL034412.1, AB001489.1, AB022219.1, M84800.1, AF147847.1, AF147846.1, AF147845.1, AF147844.1, AF147843.1, AF147842.1, AF147841.1 , AF147840.1, AF147839.1, AF147838.1, AF147837.1, AF063009.1, U76307.1, AC005271.1, U89959.1, AJ252011.1, AL139078.2, U53151.1, Z95325.2, S41204.1, AL049558.1, Y09076.1, AE003714.1, AC004159.1, AC008282.2, AFl 16775.1, AC004473.1, AL049834.3, AP001341.1, AB022220.1, AW673739.1, AI924794.1,

AA505423.1, AA547973.1, AW476696.1, AI375468.1, AA490741.1, AI650930.1, N33900.1 , T80743.1, AW390137.1, AW123976.1, AV161628.1, AV054231.1 , AV278595.1, AV084476.1, AW744691.1 , AW744450.1 , AW533639.1, AV282413.1, AV044333.2, AI551443.1, AA894037.1, AU015537.1, AI060677.1, AA914429.1, AA124598.1, AA106135.1, AA091966.1 , AW612625.1 , AW590439.1, AW580242.1, AW470767.1, AW419111.1 , AW414987.1, AW235931.1, AV264281.1, AV262910.1, AW010145.1, AW003523.1, AI969923.1 , AI932268.1, AI913209.1, AI767599.1 , AI683830.1 , AI674202.1 , AI662375.1 , AI631854.1 , AI623462.1 , AI611342.1 , AI607109.1 , AI431890.1 , AA999142.1, AI420398.1, AI378212.1, AI374843.1, AU001077.1, AI229770.1, AI170057.1, Al 167540.1 , AI092928.1 , AI086083.1 , AA854387.1 , AA846367.1 , AA830290.1 , AA829162.1 , AA825305.1 , AA805644.1 , AA764831.1 , AA620645.1, AA481088.1, AA458626.1 , AA450287.1 , AA291 148.1 , AA281054.1, AA226512.1, AA226197.1 ,

AA168415.1, AA165253.1 , R42183.1, AC027238.2, ACOl 1626.2, AC009901.3, AC040166.2, AC009040.4, AC023922.2, AC034280.2, AC016836.3, AC009967.3, AP001767.1, AP000873.1 , AC025572.7, AC021850.4, AC021433.3, AC006914.1, SEQ ID NO.341

NGO-St- 148 combined

AL137480.1, AB023231.1, U40750.2, ALI61537.2, AL035528.2, AC010163.7, AC010349.7, AF039218.1 , Z81543.1, M94288.1, M94287.1, NM H6445.1, AC006836.6, AC024818.1 , AC024807.1, NMJH3738.1, AF228603.1, AF170564.1, AC009248.6, AF157600.1, AL079303.3, AL109943.18, AL132767.7, Z82060.1, AL049557.19, X13299.1, AB004907.1, L24799.1, AC006830.1, U50068.2, AC005158.2, AF022981.2, AC003667.1, Z78067.1, AL031321.1, Z96050.1 , Z46833.1, AB006697.1 , X73124.1 , AWl 17284.1 , AA262295.1 , AW360988.1 , AW802874.1 , AA971329.1 , AI083506.1 , AI334961.1, AA828106.1, AI804127.1 , AI356296.1, AI350150.1, AA332524.1, AA069718.1, AW802869.1, N49573.1, AW589778.1, AI867753.1 , AI760381.1, AW802871.1, AW456665.1, AW455922.1, AA262179.1, AW491676.1, AW296806.1, AA313126.1, AA317431.1, AA175408.1, AV353681.1, AI050623.1, AW372307.1, AV247054.1, AW601336.1, AV353772.1 , AA739466.1 , AW463082.1 , AA069694.1 , AV331020.1 , N46881.1, AI583051.1 , Z21094.1, AW372290.1 , R93780.1, AI885774.1, AI564960.1, AI078757.1 , AA189821.1, AW007570.1, AV370618.1, AW145277.1, AI607201.1, AA963498.1, AA645938.1, AW856031.1, AW545487.1 , AW539636.1, AW271206.1, AW159052.1, AW139577.1, AI659421.1 , AI605334.1 , AI593613.1, AI394313.1, AI326844.1 , AA823548.1 , C50352.1 , AA403397.1 , AA308562.1 , AA304772.1, W01829.1, N73719.1 , H80192.1, AW689768.1, AW613941.1, AW593986.1, AW241950.1 , AW200551.1 , AV310318.1, AI945889.1, AI773675.1, AI723665.1, AI431451.1 , AI356965.1 , AI253127.1, AA042714.1, C66989.1,

AA040979.1, AA292105.1, AA195534.1, W37558.1, N76774.1, F19972.1, T60368.1, T60336.1, D15992.1, AC021443.5, AC012436.4, ACOl 1689.3, AC021800.3, AC021239.3, ACOl 1841.3, AC024298.2, AC023404.2, AC009163.4, AC015861.5, AC009778.3, AL139012.1, SEQ ID NO.342 NGO-St- 148 YS147/T3 5'

ALl 37480.1, AB023231.1, U40750.2, AL161537.2, AL035528.2, AC010163.7, AC010349.7, AC006063.1 , AF039218.1 , Z81543.1, M94288.1, M94287.1, AC007878.2, AC006836.6, AC024818.1, AC024807.1, AC002451.1, AL079303.3, AL132767.7, Z82060.1, AB004907.1, L24799.1, NC_001 141.1, AC008417.3, AC006830.1, AE003680.1 , AE003570.1, AF165175.2, AC004544.1 , AF220199.1, AC005536.2, AC009248.6, AF101319.2, U50068.2, AFl 15510.1, AC005158.2, AF022981.2, AC005731.2, AF108122.1, U52112.1, AC005179.1, AC003667.1, AF047658.1, AL163216.2, AL132641.2, AL161548.2, AL031670.6, AL137228.2, AL132774.20, AC000960.1, Z68128.1, Z81490.1 , AL009048.1, AL024497.5, AL021713.1, ALl 14454.1, AJ010712.1, Z46833.1, AP001671.1, AK000884.1, APOOl 168.1, AB007649.1, AB006697.1, AA262295.1, AW802874.1, AW360988.1, AA332524.1, AA069718.1, AW802869.1, AW589778.1, AI867753.1,

AW802871.1, AA317431.1, AW372307.1, AW601336.1, AA069694.1. N46881.1, AW372290.1, AI885774.1, AI564960.1, AW296806.1. A1078757.1, AWl 17284.1, AA313126.1, AA189821.1 , AA175408.1, R93780.1, AW456665.1, AW455922.1, AI334961.1, AI083506.1, AI050623.1, AA971329.1, AW463082.1, AI760381.1, AW007570.1, AA828106.1 , AV370618.1, AW145277.1, AI607201.1, AA963498.1, AA645938.1 , AW545487.1, AW539636.1, AI605334.1, C50352.1 , AW689768.1, AW613941.1, AW613928.1, AW593986.1, AW289470.1, AW241950.1,

AW200551.1 , AV310318.1 , AW096858.1 , AI945889.1, AVI 05697.1 , AI723665.1 , AI431451.1 , AI356965.1 , AI253127.1 , AA547168.1, AA479162.1, AA292105.1, AA195534.1, W38696.1, W37558.1, H63593.1, D15992.1 , AC021443.5, AC012436.4, AC024298.2, AL022594.18, AC010181.6, AC069244.1 , AC023797.8, AC026419.2, ACOl 1468.4, AC009163.4, AC009105.6, AC009054.4, AC015840.2, AC026948.2, ACOl 1032.3, AC013370.5, AC017069.3, AC021225.3, AC007865.5, AC009676.2, AC006871.1, AC006878.2, AC006803.2, AL133227.11, AL353726.1, AP000767.1,

SEQ ID NO.343 NGO-St-148 YS147 T7 3'

ALl 37480.1 , AB023231.1 , U40750.2, AL031 121.5, NM_016445.1, AC010349.7, NM H3738.1, AF228603.1, AF170564.1, AF157600.1, AF047658.1, AL109943.18, AL049557.19, AC008970.4, NC_001141.1 , AC004998.2, AC007392.3, AF131217.2, AC007617.10, AF124523.1 , AF165147.1, AF146367.1 , AF125463.1, AC003027.1, U49398.1, AC004582.1 , AC005222.1, AF067618.1, ALl 10292.4, AL163247.2, AF016681.1, AL133454.3, Z92839.1, AL096854.5, Z78067.1, Z98755.1, AL031321.1, AL008709.1 , AL022154.1 , AL020990.1, Z96050.1, Z46833.1, Z99123.1, X73124.1 , AWl 17284.1 , AA971329.1 , AI083506.1 , AI334961.1 , AA828106.1 , AI804127.1 , AI356296.1 , AI350150.1 , AW360988.1 , N49573.1, AI760381.1, AW456665.1, AW455922.1, AA262179.1, AW491676.1, AW296806.1 , AA313126.1, AAl 75408.1 , AV353681.1, AI050623.1 , A V247054.1 , AV353772.1 , AA739466.1 , AW463082.1 , AV331020.1 , AI583051.1 , Z21094.1 , AA262295.1 , R93780.1 , AI885774.1 , AI742950.1 , A W856031.1, AW271206.1 , AWl 59052.1 , AW139577.1 , AI659421.1, AI593613.1, AI394313.1 , AI326844.1, AI291896.1, AA823548.1, AA750605.1, AA660959.1 , AA403397.1, AA308562.1 , AA304772.1, W01829.1, N73719.1, H80192.1 , AW453398.1, AV370618.1, AI773675.1, AV024594.1, AA701705.1, AA656478.1, C66989.1 , N76774.1 , T60368.1, T60336.1 , AC021443.5, AC012436.4, ACOl 1689.3, ACOl 1841.3, AC023598.10, AC026071.2, AC035146.2, AC008784.5, AC021689.2, AC026070.2, AC023404.2, AC0241 16.10, AC027308.2, AC067914.1, AC044895.1, AC016039.3, AC025081.2, AC015861.5,

AC016010.1, AC006843.1, AL356264.2, AL160264.3, AL138903.3, AL353655.2, AL139012.1 , AP001834.1, AP000612.1,

SEQ ID NO: 344 NGO-St-149 YS184/T3 5' Sequence 797 bp

AC006151.3, AE003519.1 , AC019018.7, AC005588.1, AF104455.1, X98659.1, AP001278.1, AE003527.1, AC005065.1, AF147262.1, AL163239.2, AL161579.2, AL161578.2, AL161505.2, AL021633.2, Z54307.1, AL080283.1 , X53495.1, AP001694.1, AP000139.1, AP000226.1 , AP000087.1, X81824.1, AC002510.2, AC006717.1, AF224669.1, AC005844.7, AF126483.1 , AF097025.1, AL163241.2, AL109827.8, AL109920.15, AL132879.2, AL132952.1, AL021707.2, U80439.1, AL031075.1, AL031 1 19.1, AB030316.1, AP001696.1, AP001421.1, AB016236.1 , AK001470.1, AK001265.1, AJ010952.1, AP000154.1, AP000013.2, AA463576.1 , N56580.1, AI510521.1, AA164557.1, AA123334.1, AL079845.2, AW296098.1, AI509555.1, AA856443.1, T06332.1, AI122290.1, AI548925.1 , AW299478.1, AW075969.1 , H60790.1, AI248071.1, AA693818.1, AA703057.1, H66947.1 , T79937.1, R93072.1, AW365959.1, AA183383.1, AA184145.1, N55957.1, AV295673.1, R91524.1, AA272832.1, N53457.1, AWl 89470.1, AWl 89153.1, AI657682.1, AI457040.1, AI456849.1, Al 187906.1, AA440449.1, AA390650.1, H57909.1 , AW755551.1, AW673175.1 , AW634103.I , AW512222.1,

AW472370.1, AWl 67354.1 , AW055228.1, AW043984.1, AI856773.1 , AI856421.1 , AI831310.1, AI805882.1, AI609204.1, AI507816.1, AI492820.1, AI498201.1, AI471710.1, AI459185.1, AI449761.1, AI092297.1 , AI066451.1, AI041708.1, AA902946.1, AA885085.1, AA868367.1, AA843991.1, AA832096.1, AA739657.1, AA707993.1 , AA551869.1 , AA503125.1, AA476245.1, AA291657.1, AA291215.1, AA137908.1, AA063397.1, AA056015.1, W94514.1, W49769.1, N91044.1, N51028.1 , H73729.1, H72793.1, H17320.1, H16511.1 , R12496.1, R03444.1, F10023.1, T06260.1, AL139323.2, AL159974.3, AL139006.3, AC025368.1, AC025027.4, AC026667.2, AC021806.4, AC025226.2, ACOl 1753.2, AC009380.4, AC010004.3, AC009372.4, AC015159.1, ACOl 1900.1, AC012020.8, AC022296.8, AC011464.4, AC044876.1, AC027691.1 , AC020478.1, AC016111.1, AC020649.4, AC008448.5, AC008575.4, AC008276.2, AC018797.3, AC019292.4, AC024921.2, AC008050.3, AC020617.2, AF230637.1, AC0171 14.3, AC009713.2, AC016907.1, AL355380.1,

SEQ ID NO.345 NGO-St-149 YS184/T7 3' AC004952.2, AB002316.1, AC005171.2, AE003697.1, AC005233.2, AC008078.i l, U73509.1, AC004600.2, AC004259.1, AC008498.3, AC0O7171.4, AC024864.1, AC024206.1, AC009248.6, AF133300.1, AC007157.6, AL353814.1, Z81081.1 , AI041842.1, AA535122.1, AA858272.1, AW173550.1, AI075241.1, AI949683.1, AI459566.1, AW662874.1, AW016852.1, AI393789.1, W38376.1, AI660675.1, AW374022.1, AI092706.I, AA614653.1, N22273.1, AI374912.1, N81171.1, AI307141.1, AW316689.1, AA702628.1, N50149.1, AA665756.1, AA908261.1, AA906275.1, AA122792.1, AI228214.1, R81288.1, AA789088.1, AI149042.1, AW544305.1, AA016222.1, AA781542.1, AA907460.1 , AI787663.1, H9591 1.1, AI747696.1, AI408499.1, H69908.1, AA185425.1, AA493271.1, D82413.1, AI449623.1, AW020583.1, AA399746.1, AA165348.1, AI549947.1, AA458167.1, AA690581.1, C86225.1, C85754.1, AV296844.1, AA476396.1, AJ394925.1, AI227433.1, AA901298.1, AV314025.1, AV366383.1, AV304720.1, AV298962.1, AJ395178.1, AW803080.1, AV295103.1, AV304O45.1, AV295412.1 , AW365959.1, AW356172.1, AI457971.1, AJ392175.1 , AW805830.1, AI922173.1, AW010332.1, AA620178.1, AI974964.1, AW863569.1, AW285356.1, AW017227.1,

AI976687.1, AI976615.1, AI975238.1, AV159280.1, AI803639.1, AV089896.1 , AI471454.1, C99130.1, AA508293.1, AA508283.1, AA508275.1, AA233975.1, AA185761.1, AA185758.1, AA185813.1, AA185829.1, AA133583.1, Z45321.1, AL159974.3, AC025368.1, AC017000.2, AC024737.5, AC063941.4, AC063926.3, AC025837.2, AC023555.3, AC021587.1, AL356320.1, AL355606.2, AC068498.1, AC027320.2, AC026425.2, AC016099.3, AC022608.2, AC021603.2, AC006095.1, AL355532.4,

SEQ ID NO.346 NGO-St-150 YS255/T3 5' AL137786.2, AEOOl 106.1, AL109657.8, AE003536.1, AL032649.1, AC000095.3, AC010283.5, AC007370.7, U02206.1, U39718.1, AC005319.1, AL163237.2, U59177.1, U59176.1, AL031729.16, Z70754.1 , Z98885.1, L41917.1 , L41886.1, X05181.1, X04572.1, AP001692.1, AP000147.1, AP000233.1, Z99105.1, Z99104.1, D14465.1, AB006424.1, D81907.1, AA186486.1 , AI752319.1, AW515316.1, AI633878.1, AA724174.1, N98699.1, AW088411.1, AI818209.1, AA360504.1 , AW207435.1, R77568.1, D78858.1, AW083012.1 , AI927938.1, AI669659.1 , AA902264.1 , AW105148.1, H83314.1, AA300827.1, AW410334.1, AA431514.1, AI420205.I , AI752320.1, AI283114.1 , D78824.1, AI743602.1, AI417561.1 , W00707.1 , N66098.1 , N90043.1 , AA573278.1 , AA043792.1 , COO 128.1 , A W796219.1 , AI819645.1 , A A329088.1 , AW796258.1, AA043666.1, AI434568.1, AA973972.1 , AI631297.1, AI638738.1, AI440413.1, AI048750.1 , AI702887.1, AA431188.1, AA653570.1 , AA348799.1 , AI749472.1 , AA210446.1 , A W275782.1 , AW275777.1 , AA 105091.1, AA137746.1, AA704575.1, AA561636.1, AA096434.1 , AI753861.1, AJ396210.1 , AJ394687.1 , AI962149.1, AA809488.1, AI440138.1, AL135399.1, AI058992.1, D62361.1, AW089455.1, AW322669.1, AAl 14807.1, AI925346.1, AA120374.1, AA153007.1, AW342822.1, AI982313.1, AA174177.1, AI981814.1, AU017382.1, AA561870.1, AW363585.1, AI576378.1, AW734057.1, AW333950.1, AW332559.1, AW257529.1, W31991.1, AC027672.3, AC013243.4, AL133461.2, AC023317.2, AL161659.10, AC010031.5, AC013267.2, AC017582.1, AL008876.1, AC016927.5, AC024903.5, AC068921.2, AC009463.6, AC008368.18, AC010448.4, AC009162.5, AC010727.3, AC021484.3, AC017044.2, AC022372.3, AC010901.3, AC019010.1, AC009624.2, AL353145.2, AL161451.4, AL138878.3, AL133543.2. AL031744.7,

SEQ ID NO.347 NGO-St-150 YS255/T73'

AE003626.1, AC005890.1, AL034556.3, AL008971.1, AC008873.4, AE003736.1, AE003708.1, AC005242.1, AF034902.1, AL163225.2, AL132796.2, AL031905.7, AL035530.11, AJ131836.1, AL035532.1, AC008865.3, AC007047.6, AE003545.1, AE002786.1, AC004547.1, AC005251.1, AC012680.3, AC005489.1, AF121782.1, AC006421.1, AE001428.1, AE001413.1, AF078780.1, AF064857.1, AL163281.2, AL133299.2, Z99773.1, AL096770.14, U39847.1, Z99281.1, Z68215.1, Z97055.1, Z97209.1, U32078.1, U50071.1, Z31356.1, U21731.1, AJ235270.1, AB015469.1, Y11842.1, X94355.1, AW771521.1, AA126445.I, AW514659.1, AW182807.1, AW771502.1, AA938728.1, AI090291.1, AI493810.1, AW675411.1, AA427532.1, AA349431.1 , N62707.1 , AW512566.1, AA058340.1, AA345941.1, AA588743.1, AWl 89042.1, AA187281.1, AW089555.1, AI678159.1, AI366801.1, AA829470.1, C02522.1, AI332895.1, T40865.1, AA970774.1, D79887.1, AA456027.1, AW149169.1, AI220712.1, AA310489.1, T40872.1, AI932606.1, AI587187.1, AA054496.1, D61745.1, AA126569.1, AA455387.1, AA292619.1, AA767314.1, T39804.1, T39783.1, AA766576.1 , AA292620.1 , AW315966.1 , AW312359.1 , AI551720.1 , AA445754.1 , Al 157081.1 , AA879725.1 , AW347573.1, AI527455.1, H64492.1, AI341051.1, AI082974.1, AW863369.1, AW637708.1, AW618562.1, AW618323.1, AW610946.1, AW533222.1, AW528171.1, AW514564.1, AW399714.1, AW399655.1, AW349594.1, AW293159.1, AW276976.1, AI843747.1, AI663436.1, AI392688.1, AI288400.1, AA805183.1, AA561027.1, AA537476.1, AA455793.1, AA447110.1, AA434507.1, AA282194.1, AA101103.1, R81554.1, AC013243.4, AL133461.2, AC027672.3, AC018864.4, AF215845.1, AC069162.1, AL355312.3, AC020324.1, AC007291.23, AL356254.1, ACOl 1970.1, AC009613.2, AL163537.4, AL157957.1, AC068957.1, AC067779.1, ACOl 1562.4, AC019950.1, AL121928.10, AL157396.3, SEQ ID NO.348 NGO-St-151 YS1652 T3 5'

AC003682.1 , X 15544.1 , X 16618.1 , AK000267.1 , M29411.1, NM_007673.1 , AF 104031.1 , Z81009.1 , S74520.1 , U00454.1 , ACOl 1749.2, AE003587.1, NM_005231.1, NM_006030.1, AC004793.2, U34879.1, AF040709.1, U37521.1, AF054997.1, AF042793.1, AF042792.1, AJ251368.1, AJ251367.1, Z84492.2, AJ251914.1, AL121757.7, Z92845.1, L31886.1,

AB040919.1, Z35691.1, M98343.1, ABOl 1130.1, AA160768.1, AA454976.1, AA524918.1, AA160767.1, AW177242.1, AA524934.1, AW603587.1, AI909371.1, AW754009.1, AW604563.1, AW843725.1, AA236418.1, AA327082.1, T64077.1, AI981337.1, AI795303.1, AI639685.1, W78194.1, AW761561.1, AW326881.1, AW326538.1, AI327188.1, AI323297.I, AI273360.1, AI272717.1, AA876719.1, AA016882.1, W63915.1, N39838.1, AW699234.1, AW677045.1, AW658137.1, AW578415.1, AW392015.1, AW370009.1, AL134942.1, AW034847.1, AI527711.1, AA543942.1, AA378725.1, AA315097.1, W14378.1, W07354.1, U18015.1, T49796.1, AC068266.1, ACOl 1089.4, AC006330.3, AC061995.1, AC024115.7, AC021247.4, AC027349.1, AC022585.1, ACOl 1166.2, AL133331.12, AL158834.4, AL353680.3, AL158065.3, AP001374.1, AP001339.1, AC010299.4, AC009143.4, AC009123.5, AC009041.5, AC017067.3, AC010131.2, AC025353.2, AC046157.1, AC023825.3, AC026070.2, AC035886.1, AC035885.1, AC028189.1, AC019231.3, AC022608.2, AC016716.2, AC011035.3, AC017033.2, AC024117.1, AC012004.3, AC021764.1, AC015049.1, AC008228.2, AL356241.2, AL355483.2, AL356116.1, AL356007.1, AP001554.1,

SEQ ID N0.349 NGO-St-152 YS1704/T3 5'

AB033096.1, AF031242.1, M84990.1, L06863.1, U82671.2, AC003991.1, AF134576.1, AF070552.1, AC004040.1, U82696.1, AC001231.1, AL135745.2, AL121774.3, AC001477.1, AL133220.1, Z69655.1, Z33874.1, AW847517.1, AW762077.1, AW437401.1, AW463000.1, AI005887.1, AA133529.1, AI959464.1, AI650192.1, AA578951.1, R15953.1, M75813.1, AC026573.3, AL353588.2, AL353672.2, AC010195.7, AC009520.7, AC010274.3, AC010464.4, AC046150.2, AC025353.2, AC010864.2, AL139090.3, AL022344.1, ACOl 1966.3, AC024727.4, AC009362.5, AC009180.7, ACOl 1967.3, AC009621.4, AC007846.2, AC023959.2, AC023850.2, AC007608.2, AC007728.1, AC021596.1, AL136171.6, AL162741.3, AL162731.2, AL161933.3, AL139405.2, AP001591.1,

SEQ ID NO.350 NGO-St-152 YS1704/T7 3'

AB033096.1, AC004812.1, AL133249.1, AC000052.16, AC004019.20, U62317.2, AL163285.2, AC002091.1, AL050307.13, AC000134.14, AC007051.3, AL031289.1, AC005412.5, AC006273.1, Z98884.11, AL034350.2, AL033392.5, AC005755.1, AF001549.1, AL160237.2, ALl 10502.1, AF053356.1, AC010328.4, AC008518.3, AC007917.15, AC007066.4, ALl 17352.12, U75285.1 , Z83823.1, AC000159.6, AC020663.1 , AC005288.1, AC004821.2, AC005324.1, AL121601.13, AL03541 1.27, AP000555.1 , AC006344.2, AC006480.3, AC005856.1 , AC005215.1 , AC004057.1, AC008079.23, AC016025.12, AC008101.15, AC006138.1, AL023882.2, AL031224.1, Z95152.1, AF064862.1, AC004087.1, AC005231.2, AL096700.14, AC009516.19, AC005747.1, Z97630.1 1, AC005500.2, AC004982.1, AF037338.1, AC005785.1, AL133353.6, AL121964.16, AL096712.20, AP000188.1, AP000044.1, AP000112.1, AC007312.1, AC007097.4, AC005486.2, AC005013.1, AC008168.3, AC010170.3, AC005037.2, AP000193.1, AC007956.5, AC007055.3, AC006207.5, AC004210.1, AL049780.2, AC008925.3, AC006046.1, AP000191.1, AP000115.1, AC007655.1, AC005089.2, AC005740.1, AL033525.10, AC005018.2, AL022727.1, AP001412.1, AP000152.1, AC006582.13, AC000081.2, AC003006.1, AC007057.3, AP000692.1, AC007565.1, AP001331.1 , ACOl 1465.4, AC007766.1, W79504.1, AF150152.1, AI246796.1, AW303196.1, AW274349.1, AA441788.1, N54902.1, AI284640.1, AW872676.1, AW473467.1, AW301350.1, AA557686.1, AL135724.1 , AI684097.1 , AL041706.1, AW473163.1, AW168342.1, AW022379.1, AI633168.1, AI334435.1, T41242.1, AW338508.1, AI471481.1, AA381147.1, AL079645.1 , AI732186.1 , F36273.1, AI635818.1, AI569086.1, AI281881.1, AI160117.1, AI079910.1, AA598586.1, AA502155.1, AA491814.1, AA147750.1, AW057877.1, AI873916.1, AI537955.1, AA649642.1, AA487277.1, AW301809.1, AI439210.1, AA604607.1, AA 179944.1 , AW873290.1, AI499181.1, AI446464.1, AI432270.1, AI064864.1, AI061313.1, AA713891.1, AA482681.1, AL042856.3, AW088049.1, AA580808.1 , AI561255.1, AA207129.1, AA171473.1, AA223206.1, AI085719.1, AA448858.1 , AW615709.1, AW576503.1, AL138396.1, AI921061.1, AI754336.1, AI358812.1 , AI079389.1, AI076766.1, AA634196.1, AA071393.1, C06339.1 , AW081941.1, AW304805.1, AW152057.1, AW020992.1, AI920876.1, AI654247.1 , AI571562.1, AI567712.1, AI358813.1, AI351698.1, AI289447.1, AI087133.1, AA533060.1, AI125107.1, AA765170.1, AA634272.1, AA633582.1, AA598425.1, AA551409.1,

AA485930.1, AA151690.1, AAl 15165.1, AA082854.1, AA053128.1, W49595.1 , N64547.1, AA443390.1 , AL353672.2, AC026573.3, AL353588.2, AC009444.2, AC004795.2, AL137222.3, AC026413.2, AC017099.3, AC024088.3, AC008610.4, ACOl 1442.3, AC011938.3, AC021455.3, AC018821.3, AC025287.2, AC020954.5, AC024438.2, AC013371.4, AC051660.3, AC019280.3, AL353729.2, AC017057.5, AC025341.2, AL136300.9, AL158830.5, AC023156.3, AC010607.4, AC034121.2, AC010130.4, ALl 17259.2, AC010395.5, AC009191.4, AC026397.2, AC013805.4, AC022181.3, AC023583.2, AC022460.2, AL161731.4, AL136311.3, APOO 1528.1 , AC00778O.2, AC026587.2, ACOl 7083.4, AC023359.6, AC067749.2, AC026964.2, ACOl 8989.3, ACOl 1845.3, AC026294.1, AC022911.2, AC055890.2, AC024934.8, AC055791.2, AC025683.2, AL139109.2, AL138901.2, AC017100.3, AC009268.2, AC018862.3, AC024005.2, ACOl 1092.1, AC025559.2, ACOl 1443.4, AC007491.3, AC025145.2, AC027497.2, AL121971.2, APOO 1076.1 , Y 12335.1, AC026546.2, AC034181.1 , AC022286.4, AC021024.2, AC021933.1, AC010455.3, AC024990.2, AC019206.3, AC021671.1, AL354986.1, AC022169.2, AC022966.2, AL355348.3, AF228728.1, AC025354.2, AC015726.3, AP001098.2, AC026050.3, AC025963.2, AC012128.3, AL160393.6, AC063960.2, AC022261.3, AC019291.4, AL356292.1, AC040922.2, AC012411.3, AC027546.1 , AL353749.1, AC055767.1, ACOl 1638.3,

SEQ ID NO.351

NGO-St-153

YS1754/T3 5'

AC004498.1 , AC007956.5, AE003532.1 , AF050157.I , Z37979.1, AC003028.2, AE003794.1, AE003615.1, AC006530.4, AC007977.11 , AC006120.1 , AE000679.1 , ALl 33073.1 , Z69662.1 , Ul 1039.1 , Z991 13.1 , Z99112.1 , AI005288.1 ,

AI750442.1 , R44564.1, F01704.1, AW614231.1, AW058657.1, AI808100.1, AI743405.1 , AI726212.1, AI692280.1 , AI675621.1, AI343951.1, AI342528.1, AA400627.1, AA400382.1, H00353.1, R56558.1, AW530608.1, AW530607.1, AI941583.1, AV185720.1, AI229512.1, C42486.1, C42424.1 , AA470046.1 , AA446177.1, AA398518.1, AA393260.1, AA090525.1, D75049.1, AL138764.3, AL355355.1, AC008528.5, ACOl 1350.4, AC008591.4, ACOl 1325.8, AC013337.5, AC024018.1, ALl 18511.22, AC024400.2, AC025205.2, AC022816.9, AC022059.2, AC019274.3, AC013814.3, AC023206.2, AC012359.3, AF215849.1, AC019852.1, AP001564.1, AC068133.2, AC026029.3, AC023332.3, AC064814.3, AC009452.9, AC068727.1 , ACO 10398.6, AC009440.2, AC013570.3, ACOl 1116.3, AC019264.3, AC018606.3, AC025827.2, ACOl 1278.4, AC020571.2, AC010858.3, AC022955.3, AC022937.3, AC007838.10, AC024032.2, AC012287.2, AC020967.1, AC019998.1, AC012229.2, AC018325.1, AC008345.2, AL158837.4, AL160235.1 ,

SEQ ID N0.352 NGO-St-153 YS1754/T7 3' AFl 19869.1, ACOl 1297.3, AL031599.1, AC016951.9, AC007129.3, AC005412.5, AC006409.2, AF027153.1, AL163264.2, AL121761.5, AL121756.14, AL023096.1, AP001719.1, AP000467.1, AP000496.1, AP0001 18.1, AB020874.1 , AC000036.5, U91318.1, U95740.1, AC004409.1, AL132715.2, Z92844.1, AP000074.1 , AC002038.1, AC000361.1, U91326.1, AC002544.1, AC005619.1, AL050325.20, Z84466.1, U01337.1, L24038.1, AC005781.1 , AF001552.1, U91321.1 , AC004962.1, AC003969.1, AC005224.1, AC004499.1, AC002549.1, AL080286.16, AL050312.8, Z82194.1, AL035459.6, AL031657.2, M21488.1, AP000545.1, AP000544.1, AC000105.41 , AC005191.1, AC004874.1 , AC007358.2, AC006961.16, AC006552.7, AC004032.7, AC004126.1, AC004501.1 , AL163259.2, AL078582.13, AL035683.9, ALl 17694.3, AL035665.29, AC002070.1, AL023513.1 , AL035693.19, AL049749.2, Z73420.1, Z95116.1, Z82196.2, AL049709.15, Z92545.1 , AL022577.1, AL034424.9, Z93016.1, AP001714.1, L35930.1, Z83733.1, ACOl 1595.12, AC005165.1, AC007649.12, AC006230.i l, AC002375.1, AL096814.26. Z83851.17, AL031651.33, AL035684.25, AL031054.1, AL031984.13, AC005895.1, M99412.1, AC004147.1, AL031674.1, U95743.1, AC006965.3, AL023804.1, AL031256.1 , Z83732.1, AA583783.1, AA352852.1, AI750443.1, T97047.1, AI206381.1, AW779140.1, AW392720.1, AW392037.1, AW375505.1, AW375664.1, AI917309.1, AI245002.1, AA972389.1, AA348114.1, H83083.1, AI677865.1, AW081092.1, R68753.1 , R36634.1 , R361 14.1, T39347.1, AL134762.1, AI950057.1, AI948415.1 , AI913632.1, AL043389.1, AI760277.1, AI636038.1, AI422711.1, AI174489.1, AI097075.1 , R92107.1, R36101.1,

AW205700.1 , AI857496.1, AI241546.1, AI052617.1, AA862242.1 , AA682503.1, AA283058.1, AA010393.1, W87478.1, R98769.1, AW769350.1, AW631324.1 , AW606680.1 , AW380595.1, AW358828.1, AW170684.1, AI968735.1, AI916948.1, AI823617.1 , AI798803.1, AI793154.1, AI692607.1, AI654898.1, AI208889.1, AI076838.1, AA770067.1, AA631910.1, AA613927.1, AA548931.1, AA426207.1, AA180428.1, AA128302.1, H54911.1, H16066.1, H14830.1 , R46689.1, R09295.1, R09229.1, T91813.1, F12420.1 , T74282.1, T66898.1, AW406178.1, AWl 13986.1 , AI741532.1, AI674059.1, AA883361.1, AA754905.1, AA635120.1, W22245.1, N53160.1 , H79438.1, H78261.1, Z41544.1 , AL138764.3, AC017088.3, AC025558.3, AC016313.5, AL139785.1, AC018943.4, ACOl 1652.4, AC022188.3, ACOl 1247.3, AL109615.18, AL355388.2, AL139019.2, AL158169.1, AC068877.1, ACOl 1388.4, AC008472.4, AC009823.3, AC016823.4, AC020766.3, AC007602.3, AC025589.6, AC025226.2, AC016399.5, AC009031.2, AC010755.1 , AC007499.1, AL136368.5, AL133478.2, AL138779.3, AP001337.1, AC022844.3, AC068570.1, AC023403.2, AC022494.3, AC012666.2, AC010866.1, AL354873.3, AC009128.5, AC027486.2, AC046169.1, AC012222.3, AC018499.2, AL162293.7, AL136131.7, AP000868.1, AP000481.2, AC069233.1, AC069079.1, AC016530.3, AC015977.3, AL121889.7, AL138766.2, AC036218.2, AC007569.8, AC022362.5, AC064817.3, AC008714.2, AC008485.3, AC008484.3, AC008977.3, AC027064.2, ACOl 1687.3, AC027580.1, ACOl 1846.5, AC027143.1 , AC024910.2, AC027081.1, AC026403.1, AC022684.2, AC022379.1, AC007607.2, AC022818.1,

AC022259.1, AL121987.2, AL355875.2, AL161745.5, AL136086.2, AL162387.3, AL157942.2, Z97197.3, AP001838.1, AP000777.1, AC067823.2, AC068710.1, AC008623.3, AC023390.2, AC023825.3, AC021990.3, AC023487.3, AL355300.2, AL161795.2, AC007339.3, AC023091.2, AC022724.1 , AL355865.1, AP000848.1, AC026906.2, AC025868.2. AC036238.1

SEQ ID NO.: 353

Kinesin

NM_005552.1, L04733.1, M75148.1 , M75147.1, M75146.1, X69658.1, NM_008450.1, AF055665.1, Y14586.1, U48359.1 ,

AE003540.1 , AF055298.1 , LI 1328.1 , LI 1013.1 , NM_008451.1, AF055666.1 , L47236.1 , S83098.1 , Z86099.2, AC007244.2, NM_004812.1, AC005027.2, AF052577.1, AC005369.1, L47235.1, AC002366.1, U37100.1 , AL353815.1, AL022238.1, U41356.1 , U18937.1, D90155.1, D88672.1, AE003569.1, AE003505.1, NMJH2656.1, NM_007764.1 , NM_001323.1, AF108766.1, AF145609.1, AF125259.1, AFl 16268.1 , AF093569.1, AF077403.1, AC003973.1, U81233.1 , U40232.1, AJ243516.1 , AL135978.2, AJ251761.1, AL161517.2, S73375.1, AJ245739.1, U62800.1, AL049754.1, AL049524.1 , XI 4820.1, X84047.1, Y09072.1, Y13714.1, X75972.1 , X90648.1, Y14406.1, X76785.1, X52606.1, AP000606.1, AB018494.1, AB026650.1 , M34270.1, AJ001448.1, D56386.1, AI124665.1, AI879287.1, AW249376.1,

AU076730.1, AL137941.1, AA326459.1, AU080282.1, AU079963.1, M85516.1, AL134331.1, AI576961.1, AU080666.1, AI840068.1, AU067555.1, AI579813.1, AU067583.1 , AA853868.1, AA230534.1, AW068178.1, AI715455.1 , AI576664.1, AI839935.1, AI710740.1, AU079968.1, AI844836.1, AI835061.1, AI849047.1 , AI838234.1, AA323263.1, AA509865.1, AW533285.1, AA647015.1, AA015415.1, AI847415.1 , AU067068.1, AI576960.1, AU035615.1, AI073056.1, AA611446.1 , AI839802.1, AI704444.1 , AA518630.1, AI834986.1, AU035489.1 , AU079966.1 , AI840457.1 , AI837501.1, AW213300.1, AA410206.1 , AI837150.1 , AA074408.1 , Wl 1435.1 , N99532.1 , AA615751.1 , AU066979.1 , AW533735.1 , AL043408.1 , AI838411.1, AI837539.1, AU035788.1 , W40723.1, AU051216.1, AI837589.1, AI643860.1, All 17342.1, AW529922.1, F06922.1 , AU035505.1 , AI787782.1 , AU078909.1 , AI834799.1 , AA839731.1, AA794060.1 , AA920796.1 , AW525818.1 , AI602475.1, AI579543.1, AI579510.1, AI579008.1, AA964280.1, AA818427.1, AI101378.1, AW012089.1 , AA943900.1, AW653245.1, AW522687.1, AA997897.1 , AH 12976.1, AI641838.1, AA219531.1, AA637666.1, AA007747.1 ,

AWl 84674.1 , AI959425.1, AI199976.1, AA403503.1, AU066670.1, AI554005.1 , AA871286.1, AL139300.2, AC023803.3, AL355385.2, AL136304.2, AP001812.1, APOOl 107.2, AP000630.1, AC017329.1, AP000759.2, AC012160.5, AL132666.3, AC006448.10, AC055757.3, AC068941.1 , AC068920.1, AC009276.7, AC019217.4, AC025828.1, AC021436.3, AC025369.1, AC023304.1, AC021226.1, AC021526.1, AC016103.1, U82207.1, AL158822.4, AL354761.1

SEQ ID NO: 354

ZH068/T3

NM_005552.1, L04733.1, X69658.1, M75148.1, M75147.1, M75146.1, U48359.1, NM_008450.1, AF055665.1, S83098.1, Z86099.2, AE003547.1, AC019014.1, AL353815.1, AL022238.1, U41356.1, D90155.1, AE003775.1, NM_007764.1,

NM_001323.1, AF108766.1, AC007655.1, AF077403.1, AC004049.1, U81233.1, U40232.1, AL135978.2, AL161517.2, S73375.1, U62800.1 , AL049754.I , AL049524.1, Y09072.1, X90648.1 , X52606.1, AP000606.1, AB026650.1, D56386.1, AW249376.1, AI879287.1, AU076730.1, AA853868.1, AL134331.1, AA410206.1, N99532.1 , AA074408.1, AI124665.1, AU067068.1 , AU066979.1, AU035505.1, AW213300.1, AU080282.1, AU079963.1, AU067583.1, AU035788.1, AU035615.1, AU035489.1, AW529922.1 , AU067555.1 , AA647015.I , AA230534.1, AA015415.1, W40723.1, AI787782.1, AU078909.1 , AA518630.1 , AA615751.1 , AA509865.1 , AA326459.1 , AU080666.1 , AU079968.1 , AU079966.1 , Al 117342.1 , AA794060.1 , AU051216.1, AA839731.1 , AA920796.1 , AI840068.1 , AI576961.1, AA219531.1 , N84649.1 , AI816679.1, AW727794.1, AW730774.1, AI579813.1, N84562.1, AW730835.1, AI816625.1 , AI816616.1, AI816604.1, Wl 1435.1, AW726912.1, AW547881.1, AV387868.1, AW212176.1 , AW046482.1, AI885674.1, AI871 196.1, AI841137.1, AI804245.1, AI743831.1, AU066670.1, AI447212.1, AI368578.1 , AH 60826.1, All 60877.1, AI127958.1, AI074600.1, AA793909.1, AA778147.1, AA733052.1, AA72651 1.1, AA722826.1, AA475518.1, AA444522.1 , AA220560.1, AA158109.1, W82825.1, W84293.1, AA051553.1, AA051548.1, AA032527.1 , AA033314.1, AA028401.1, W72895.1, W65322.1 , W56781.1, AL139300.2, AC023803.3, AC012160.5, AL132666.3, AC068941.1 , AC068920.1 , ACO 19217.4, AC025828.1, AC025369.1, AC010058.5, AC023304.1 , AC021226.1, AC021526.1, AC020284.1 , AC016103.1, U82207.1, AC006097.1, AL158822.4, AL354761.1, AL133482.5, AC012022.5, AC068296.3, AC020982.3, AC0I0588.6, AC008622.4, AC008505.4, AC009110.5, AC008687.3, AC027517.2, AC027274.2, AC016881.4, AC026008.2, AC025983.2, AC010823.3, AC025049.2, AC025539.2, AC019200.2, AC020602.2, AC023174.1 , AC012356.3, AC021612.1, AC013569.3, AC014778.1 , AC007821.3, AL355773.1

SEQ ID NO: 355 ZH068/T7

AL133587.1, NM_005552.1 , L04733.1, AF037222.1, Y14586.1, M75148.1, M75146.1 , M75147.1, NM_008450.1, AF055665.1 , AE003498.1, AL138995.3, AL109758.1, AJ006920.1, M30933.1, AC005817.7, AC007920.18, AC008757.5, AC008806.4, AE003616.1 , AF146041.1, AF146040.1, AF037207.1, AF044311.1, U20824.1, AF032908.1, AL163271.2, AL163265.2, AC000403.1, AL160371.1, U59924.1 , AL137646.1, AL008733.10, AJ250724.1, Z98047.1, Z68873.1, X75837.1, U16720.1, AP001726.1, AP001720.1, L27056.1 , D26607.1, D85922.1, X76303.1, X88930.1, AP001081.1, AP001073.1, AP000697.1, AP000171.1, AP000056.1, AP000330.1, AP000124.1, L26914.1, L23210.1, M95296.1, L10693.1, M93718.1, M95674.1, M99057.1, M89952.1, Y13909.1, X80330.1, ABOl 1094.1 , AI890626.1, AW249492.1, AI972783.1, AI703377.1, AW340857.1 , AI973281.1, AI863270.1, AA768039.1 , AI925587.1, AA779883.1, AA713665.1, AI915584.1, AA621710.1, AA748819.1, AW66241 1.1, AA598434.1, AI696373.1, AI698409.1, AA853867.1, AL043409.1 , T47479.1, T29447.1, AI652911.1, AI6341 15.1, AW196565.1, AA477672.1, AI702023.1, AI648382.1, AA826914.1, AI571056.1, N52851.1 , AW146276.1, AA217120.1, AW742846.1, AI879667.1, AI097557.1, AW089057.1, AW070687.1, AI377204.1, AA284075.1, AW749735.1, AW138863.1, AI422004.1, H21003.1, AI424093.1 , AA899876.1, R35099.1, AI874768.1, AA476716.1, AW495295.1, AW108197.1, AA212157.1, W81854.1 , W62338.1, H33481.1, AA270658.1 , W16197.1, H20962.1, AA683381.1, W46349.1, AA734911.1, W99868.1, AA000386.1, AW802827.1, AW434399.1, AA167982.1, AA032596.1, H27867.1, AI472226.1, AI702024.1, AW370572.1 , AWl 78030.1, AW178028.1, AW632540.1, AWl 77972.1 , AV356544.1 , AV354772.1 , AV327680.1 , AV287310.1 , AV287072.1 , AV285474.1 , AV319299.1 , AV237769.1, AV222402.1, AVI 68848.1 , AI536415.1, AI451945.1, AA9641 14.1, C86292.1, AA008923.1, W53783.1, W13977.1, AL049840.3, AL139300.2, AC019143.3, AC025533.3, AC009695.4, AC025864.2, AC010845.7, AC008255.7, AC012931.1, AC010973.3, AC022462.3, AL138781.2, AC069069.1, AC025468.3, AC025460.3, AC016590.5, AC026467.3, AC008761.3, AC007779.2, AC026668.2, AC046154.1, AC025039.3, AC022051.3, ACOl 8427.3, AC025268.2, AC020884.2, AC012675.4, AC010564.5, AC010108.3, AC013664.1, AC017969.1, AC015824.2, AC013259.1, AC008327.2, AC007936.1 , AC004795.2, AC002344.1, AL157779.3, AL158078.2, ALI62401.2, AL160035.3, AL139013.2, AL139396.1, AP001888.1, AP001824.1,

SEQ ID NO: 356

ZH091/T3

NM_005552.1, L04733.1, U48359.1, M75148.1, M75147.1, M75146.1, NM_008450.1, AF055665.1, X69658.1, Y14586.1 , Z86099.2, AC007244.2, AL022238.1, U41356.1, AF077403.1, U97406.1, AC003973.1, U40232.1, AL135978.2,

AL161517.2, AL049524.1 , X52606.1 , AP000606.1, AB015478.1, AB026650.1, M34270.1, D56386.1 , AH 24665.1, AI879287.1, AL134331.1, AA326459.1, AW249376.1, AU080282.1, AU079963.1, AU067583.1, AU067555.1, AU035615.1, AA647015.1, AU067068.1, AA509865.1, AA230534.1, AU080666.1, AA015415.1, AU035489.1, AA518630.1 , AU076730.1 , AW213300.1 , AA410206.1 , AU079968.1 , AA615751.1 , AA074408.1 , N99532.1 , AU079966.1 , AI840068.1 , AU066979.1, AI576961.1, W40723.1, AU035788.1, AA61 1446.1, AI579813.1, AU051216.1, AI839935.1, AI844836.1, AI835061.1, AI849047.1, AI838234.1, AI576664.1, AI715455.1 , All 17342.1, AI710740.1, AW529922.1 , AI834986.1, AU035505.1, AW533285.1, Wl 1435.1, AI847415.1, AI787782.1, ALl 37941.1, AU078909.1, AI576960.1, AI839802.1, AI704444.1, AA853868.1, AI073056.1, AA839731.1, AA794060.1, AA920796.1, AI837501.1, AI840457.1, AI837150.1, AW533735.1, AA323263.1 , AI643860.1, AI83841 1.1, AI837539.1, AW653245.1, AU066670.1, M85516.1 , AW343448.1, AW012089.1 , AI929486.1, AI871196.1, AA692137.1, AL139300.2, AC023803.3, AC012160.5,

AL132666.3, AC020737.3, AC009088.4, AC019217.4, AC025828.1, AC021436.3, AC025369.1, U82207.1, AL355385.2, AL136304.2, AC041049.2, AC053503.3, AC025581.1, AC022424.3, AC020982.3, AC010588.6, AC008622.4, AC010269.3, AC008505.4, ACOl 1443.4, AC009110.5, AC027670.2, AC027517.2, AC013581.4, AC027274.2, AC062006.1 , AC016881.4, AC040916.1, AC019266.3, AC025983.2, AC010823.3, AC025049.2, AC025539.2, AC021214.3, AC023353.2, AC024429.2, AC019200.2, AC025726.1, AC023326.2, AC020715.2, AC023174.1, AC022970.1, AC012356.3, AC018869.3, AC013569.3, AC006893.2, AC006097.1, AL355773.1 , AL353680.3, AL117376.27, AL161941.6, Z82209.1, AL158065.3, AL161942.3, AL133482.5, AL138689.1,

SEQ ID NO: 357 ZH091/T7

AF037222.1, AL049691.17, AC004492.1 , AC002456.1, AC004888.1, AC005105.2, AC005377.2, AC005736.1, AL161670.2, AL079342.17, Z97630.l l, Z46773.1, AI652445.1, AI248698.1, AI969048.1, T96065.1, T96066.1, AA825192.1, D29556.1, AA093428.1 , N89272.1, AV21 1829.1, AW167973.1, AWl 09566.1 , AI823090.1, AI792623.1, AL047493.1, AI434780.1 , AI381339.1, AI354333.1, AH53261.1 , C89616.1, C87547.1, C87513.1, AA625193.1, AA431864.1, AA224525.1, AA149590.1, AA146232.1, R97601.1, R90943.1, R89398.1, R83387.1, H47860.1, HI 1310.1, R42599.1, R37029.1, Z22960.1, AL139300.2, AL049840.3, AL162211.3, AC027825.2, AC021087.2, AC068042.3, AC023047.11, AC008264.7, ACOl 1442.3, AC040897.2, AC022763.2, AC007430.17, AF212832.1, AC0031 17.1, AL355821.2, AL355840.1, AL031731.25, AL355822.1, AL138898.4, AL132780.1, AL137781.3,

SEQ ID NO: 358

ZH1357/T3

AF037222.1, AL049691.17, AC004492.1, AC002456.1, AC004888.1, AC005105.2, AC005377.2, AC005736.1,

AL161670.2, AL079342.17, Z97630.11, Z46773.1, AI652445.1, AI248698.1, AI969048.1, T96065.1 , T96066.1, AA825192.1 , D29556.1 , AA093428.1 , N89272.1 , A V211829.1 , AW657986.1 , AWl 09566.1 , AI792623.1 , AL047493.1 , AI605406.1, AI434780.1, AI393981.1 , AI381339.1, AI354333.1, AI054341.1, C89616.1, C87513.1, AA625193.1, AA339052.1, AA232840.1, AA224525.1, AA149590.1, H65232.1 , H57790.1 , R97601.1, R90943.1 , R89398.1, R83387.1, H47860.1, HI 1310.1, R42599.1, R06801.1, AL139300.2, AL049840.3, AL162211.3, AC027825.2, AC021087.2, AC068042.3, AC023047.11, AC008264.7, ACOl 1442.3, AC040897.2, AC022763.2, AC007430.17, AF212832.1, AC003117.1, AL355821.2, AL355840.1, AL031731.25, AL355822.1, AL138898.4, AL132780.1, AL137781.3,

SEQ ID NO: 359

ZH1361/T3

NM_005552.1 , L04733.1, X69658.1, M75148.1, M75147.1, M75146.1, U48359.1, NM_008450.1, AF055665.1, Y14586.1, AC007244.2, AL022238.1, U41356.1, NM_007764.1, AF108766.1, AF077403.1, AC003973.1, U40232.1, AL135978.2,

AL161517.2, AL049524.1, U19481.1, Y09072.1, X90648.1, AP000606.1, AB026650.1, M34270.1, D56386.1, AI879287.1, AW249376.1, AU076730.1, AL134331.1, AI124665.1, AA853868.1, AA326459.1, AU080282.1 , AU079963.1, AU067583.1, AW213300.1, AU067555.1, AA647015.1, AU035615.1, AA509865.1, AA410206.1, AA230534.1, AA015415.1, AU067068.1, AU035489.1, AA074408.1, N99532.1, AA518630.1, AU080666.1 , AA615751.1, AU079968.1, AU066979.1, AU079966.1, AI840068.1, AU035788.1, W40723.1, AI576961.1, AU051216.1, AH 17342.1, AW529922.1, AA611446.1, AI579813.1, AU035505.1, AI839935.1 , AI844836.1, AI835061.1, AI787782.1, AI849047.1 , AI838234.1, AI576664.1, Wl 1435.1, AI715455.1, AU078909.1, AI710740.1, AI834986.1, AW533285.1, AA839731.1, AA794060.1, AI847415.1, AA920796.1, AI839802.1, AI576960.1 , AI704444.1 , AI073056.1, AW533735.1, AI837501.1 , AI840457.1, AI837150.1, AA219531.1, AL137941.1, AU066670.1, AW653245.1, AW343448.1, AA263390.1, AI929486.1, AW822022.1, AW741402.1 , AW553351.1, AW547881.1, AW544029.1 , AW540274.1 , AW212176.1, AW046482.1,

AI882269.1 , AI841137.1 , AI447212.1 , AA793909.1 , AA726511.1, AA475518.1, AA444522.1 , AA260228.1 , AA220560.1 , AA158109.1, AA059905.1, W90906.1, W82825.1 , W84293.1, AA051553.1, AA051548.1, AA032527.1 , AA033314.1 , AA028401.1, W53289.1, AL139300.2, AC023803.3, AL132666.3, AC019217.4, AC025828.1, AC021436.3, U82207.1, AL158822.4, AL354761.1, AC041049.2, AC022424.3, AC020982.3, AC010588.6, AC010269.3, AC008505.4, ACOl 1443.4, AC0091 10.5, AC027517.2, AC027274.2, AC016881.4, AC040916.1, AC019266.3, AC010823.3, AC025049.2, AC025539.2, AC021214.3, AC023353.2, AC024429.2, AC019200.2, AC023326.2, AC020715.2, AC023174.1, AC022970.1, AC012356.3, AC013569.3, AC006097.1, AL355773.1, AL353680.3, Z82209.1 , ALl 58065.3, AL133482.5. AL138689.1, SEQ ID NO: 360 ZH156/T3

NM_005552.1 , L04733.1, M75148.1, M75147.1, M75146.1, Y14586.1 , NM_008450.1, AF055665.1, U48359.1, AE003540.1 , AF055298.1 , LI 1328.1 , LI 1013.1 , NM_008451.1, AF055666.1 , L47236.1 , AC007244.2, NM_004812.1 , AC005027.2, AF052577.1, AC005369.1, L47235.1, AC002366.1, U37100.1, U41356.1, U18937.1, D88672.1, AE003569.1, AE003505.1, NM_012656.1, AF145609.1, AF125259.1, AFl 16268.1, AF093569.1, AC003973.1, U40232.1, AJ243516.1, AJ251761.1, AL161517.2, AJ245739.1, AL049524.1, X14820.1, X84047.1, Y13714.1, X75972.1, Y14406.1, X76785.1 , AP000606.1, AB018494.1, M34270.1, AJ001448.1, AI124665.1, AL137941.1, AA326459.1, M85516.1, AI579813.1, AI576961.1, AI840068.1, AW068178.1, A1715455.1, AI576664.1, AI839935.1, AI710740.1, AU080282.1, AI844836.1, AI835061.1 , AI849047.1, AI838234.1, AA323263.1, AW533285.1 , AU079963.1, AU080666.1, AI847415.1 , AI576960.1 , AU067555.1, AI073056.1, AA611446.1 , AI839802.1, AI704444.1, AL134331.1, D56386.1, AI834986.1,

AU067583.1, AU079968.1, AA230534.1, AI840457.1, AI837501.1, AI837150.1, Wl 1435.1, AA509865.1, AA647015.1, AA015415.1, AW533735.1, AL043408.1, AU067068.1, AU035615.1, AI838411.1, AI837539.1, AU079966.1, AA518630.1, AI879287.1, AU035489.1, AI837589.1, AI643860.1 , AW213300.1, F06922.1, AA615751.1, AU051216.1, AU066979.1 , AI834799.1, AW529922.1, AU035788.1, W40723.1, AA074408.1, AH 17342.1, AA410206.1, N99532.1, AW525818.1, AI602475.1, AI579543.1, AI579510.1, AI579008.1, AA964280.1, AA818427.1 , AI101378.1, AW012089.1, AA943900.1, AW653245.1, AW522687.1, AA997897.1, AH 12976.1, AU035505.1, AA944331.1, AI787782.1, AI641838.1, AA637666.1, AU078909.1, AA007747.1, AW184674.1, AI959425.1, AI199976.1, AA403503.1, AA920796.1, AA839731.1, AU066670.1, AI554005.1, AI324825.1, AA442752.1, AW343448.1, AA871286.1, AI929486.1, ALl 39300.2, AC023803.3, AL355385.2, AL136304.2, AP001812.1, APOOl 107.2, AP000630.1, ACOl 7329.1 , AP000759.2, AC006448.10, AC055757.3, AC009276.7, AC025828.1, AC021436.3, U82207.1, AC041049.2, AC009661.3, AC022424.3, AC020982.3, AC010269.3, AC011443.4, AC009110.5, AC009022.5, AC027274.2, AC021876.3, AC016881.4, AC040916.1, AC019266.3, AC016356.3, AC013782.3, AC010823.3, AC025049.2, AC012345.3, AC025539.2, AC021214.3, AC023353.2, AC024429.2, ACOl 1180.3, AC023375.2, AC007336.2, AC023326.2, AC020715.2, ACOl 1707.7, AC023174.1, AC022970.1, AC012356.3, AC019768.1, AC017606.1, AC013569.3, AC006097.1, AL355773.1, AL353680.3, Z82209.1, AL158065.3, AL133482.5,

SEQ ID NO: 361 Splicing Factor Sip 1 SC35-interacting protin 1 (SRR129)

NM_005552.1 , L04733.1, X69658.1, M75148.1, M75147.1, M75146.1, NM_008450.1, AF055665.1, U48359.1, Y14586.1 , AL022021.1, Z86099.2, AL022238.1, U41356.1, M7271 1.1, X64248.1, NM_007764.1, AF108766.1, AF077403.1, AC003973.1, U40232.1, AL109663.1, AL135978.2, AL161517.2, S73375.1 , AL049524.1, Y09072.1, AL021428.1, X90648.1, X52606.1 , AP000606.1, AB026650.1, M34270.1 , D56386.1, AI879287.1, AW249376.1, AU076730.1, AL134331.1, AA853868.1 , AI124665.1, AA410206.1, AA074408.1 , N99532.1, AA326459.1, AU080282.1, AU079963.1, AU067583.1, AU067068.1, AU035615.1, AU067555.1 , AU035489.1, AA647015.1, AA015415.1, AW213300.1, AA518630.1 , AA230534.1 , AA509865.1 , AA615751.1 , AU080666.1 , AU066979.1 , AU079968.1 , AU079966.1 , W40723.1 , AU035788.1, AU051216.1, AW529922.1, AH 17342.1, AU035505.1 , AI840068.1, AI787782.1, AU078909.1, AI576961.1, AA839731.1, AA794060.1, AI579813.1, W11435.1, AA920796.1, AI839935.1, AA611446.1, AI844836.1 , AI835061.1, AI849047.1, AI838234.1, AI576664.1, AI715455.1, AI710740.1, AI834986.1, AW533285.1, AI847415.1, AI839802.1, AI576960.1, AA219531.1, AI704444.1, AI073056.1, AI840457.1, AI837501.1, AI837150.1, AU066670.1, AW533735.1, AA263390.1, AI939480.1, AI81221 1.1 , AI418988.1, AW822022.1, AW741402.1, AW553351.1, AW547881.1, AW544029.1, AW540274.1 , AI882269.1 , AI871 196.1, AI841137.1, AI447212.1 , AA793909.1, AA692137.1, AA475518.1, AA444522.1, AA260228.1, AA158109.1, AA059905.1, W90906.1, W82825.1, AA051553.1, AA033314.1 , W53289.1, AL139300.2, AC023803.3, AC012160.5, AC008687.3, AL132666.3, AC019217.4, AC025828.1, AC021436.3,

AC025369.1, U82207.1, AL158822.4, AL354761.1, AC041049.2, AC068666.1, AC020982.3, AC010588.6, AC008622.4, AC008505.4, ACOl 1443.4, AC0091 10.5, AC027517.2, AC027274.2, AC016881.4, AC040916.1, AC019266.3, AC025983.2, AC010823.3, AC025049.2, AC025539.2, AC021214.3, AC023353.2, AC024429.2, AC019200.2, AC023326.2, AC020715.2, AC023174.1, AC012356.3, AC013569.3, AC006097.1, AL355773.1, AL353680.3, Z82209.1 , AL158065.3. AL133482.5,

SEQ ID NO: 362

ZH062/T3

NM_004719.1, AF030234.1, , er of s... 1001 0.0, AC000015.2, U32169.1, U41066.1, U97190.1 , AF004910.1, AC006160.9, AC005752.1, AF048702.1 , AF047519.1, AF047518.1, , U39472.1 , L05083.1, L05082.1, L05081.1, U 17500.1 ,

NC_001137.2, AC010972.2, AC024756.1, AE003765.1 , AF187095.1 , AC002406.1, U34874.1, U18530.1, M63543.1, M63544.1, M27242.1, L26545.1, AA319947.1, AI538495.1, AA003764.1, ryo NbMEl ... 1174e-24, AW611398.1 , AW414066.1, AA919730.1, AA571070.1, AA103126.1 , ryo 13... 115 2e-23, AW835334.1, AI504981.1, AW271488.1, A W249666.1 , AI681365.1 , AI273392.1 , AI251837.1 , W56462.1 , AW782740.1 , AW284526.1 , AV091886.1 , C66973.1 , AA290444.1, N98074.1, AC010172.10, AC064878.3, , AC068734.1 , AC026445.2, AC010420.4, AC046142.3, AC013546.3, AC068309.1, AC068040.1, AC024465.3, AC026931.2, AC016388.2, AC044799.2, AC061962.1 , AC013645.3, AC024422.2, AC021913.4, AC012203.4, AC013577.2, , AC068196.2, AC023968.2, AC068563.3, AC026428.2, AC025189.3, AC008411.3, ACOl 1123.4, AC026470.3, ACOl 1320.7, AC027466.2, AC055777.1 , AC046192.1, AC025981.2, AC016773.4, AC016768.4, AC023854.2, AC025123.1, AC009213.4, AC023306.1, AC011996.3, ACOl 1897.3, AC018467.3, AC013383.1 , AF127019.2, AC014412.1, AC009707.2, AC006735.3 , AP001999.1. AP001562.1,

SEQ ID NO: 363 ZH062/T7 AC000015.2, NM_004719.1, Yl 1251.1, AF030234.1 , ALl 17351.12, AL139076.2, AC007092.4, AL031770.12, Z68295.1 , AL163273.2, Z78012.1, Z93930.10, AP001728.1, AP001432.1, AP000151.1 , AB015474.1, AP000010.2, NM_004505.1, AE003658.1, AC004841.2, AF003140.2, U87145.2, AC006471.1 , U21319.1, AF070575.1, AF057037.1, AC000114.1, AL 139229.1, AL034356.1, AL023513.1, ALl 17201.1 , ALl 17325.3, AJ243961.1. Z81145.1, AL031675.1. Z83306.1, ALl 17264.1, U56248.1 , AJ235272.1, X63547.1, X63546.1, X60459.1, AP000188.1, AP000044.1, AP000296.1, AB026661.1, AP0001 12.1, AB018263.1, X92982.1 , AA889580.1 , AW467027.1, AI753624.1, AI765502.1, AI015579.1 ,

AI742080.1, AW439997.1, AI808732.1, AI624350.1, R56692.1, R76730.1, D81292.1, H58206.1, R66856.1 , AW393523.1, AA478518.1, AW393555.1, AA459830.1, AW361894.1, AW073290.1, AI935778.1, AI524518.1, AI559753.1, H78241.1, AA604972.1, H01374.1, AI3381 17.1, AI926706.1, AI084031.1, AI039125.1, AI411610.1, AW525397.1, AA901402.1, AI012492.1, AI179529.1, AA461606.1, W60077.1, AW611398.1, AW413730.1, AW228936.1, AV363637.1 , AV31 1516.1 , AV295190.1, AW123947.1, AI644515.1 , AI462454.1, AI426341.1, AA867131.1, AA266876.1, AA203781.1, AA146549.1, AV311392.1, AJ394321.1 , AV121897.1, AI706625.1, AW599493.1, AW443257.1, AV300621.1, AV384018.1, AW094581.1, AL041793.1, AV144773.1, AI690341.1, AI580260.1, AA997487.1 , AI407787.1, AA892897.1, AI152857.1, AI147443.1, AA922552.1, AA878323.1 , AA586210.1 , AA328622.1, H09769.1, R43439.1, R42709.1, R44588.1 , R39341.1, R38267.1, F10638.1 , AC010172.10, AL136998.1 1, AL133400.6, AC007158.8, AC024622.3, AL138738.1, AC022106.2, AC008597.4, AC019243.3, AC020973.1, AC009935.1, AL096873.2, AC021863.4, AC017100.3, AC016378.4, AC025102.1, Z99775.8,

SEQ ID NO: 364 ZH085/T3 NM_004719.1, AF030234.1, Yl 1251.1, AC000015.2, ALl 17351.12, U49056.1 , AC008127.10, AC007399.1, AL109938.8, AP000003.1, NC .001140.2, AF229844.1, AC005998.3, AC006984.2, AF189155.1, AC006008.2, AC006948.4, AC005599.5, U23515.1, AC002350.1, U00027.1, AL163299.2, AL163261.2, ALl 17325.3, AL033127.1, Z19157.1, J01323.1, U08988.1, AP001754.1, AP001716.1 , AP001067.1 , AP000188.1, AB023497.1, AP000043.1, AP000295.1 , AP0001 12.1 , AW361894.1 , AI935778.1 , AW073290.1 , AA459830.1 , AI084031.1, AA461606.1 , AI524518.1 ,

AW316950.1, AI000658.1, AI453007.1, AW628965.1, AI922403.1, AW088601.1, AW083302.1 , C84289.1, H78241.1, W52849.1, AW241802.1, AA319619.1, AA867131.1, AW467027.1, D81292.1 , AI179529.1, AI012492.1, AW525397.1, AI990580.1, AI352557.1, H62920.1 , R91 171.1 , AA574243.1, AA901402.1, AI411610.1, AI002763.1, AA093717.1, AA384066.1, AA296633.1, AW390895.1, AI426341.1, AW228936.1, AW123947.1, AI152857.1, AA2721 13.1, AI120842.1, AI644515.1 , AI462454.1, AA093740.1, AA692961.1, AA600109.1, AA146549.1 , AA203781.1 , AA359862.I, W08813.1, T96952.1, R76730.1, R56692.1, R66856.1, AA359831.1, AA889580.1, AA290444.1, AI154265.1, AA359605.1, AI643169.1, AA561434.1, AI808732.1, AI504929.1, AA374554.1, AA266876.1, AI706625.1, AJ394321.1, AW611398.1, AI624350.1 , AC010172.10, AC025996.3, AC019038.3, AC068939.1, AC022148.4, AC016934.3, AC027273.2, AC025215.1, AC022025.1, AC009522.2, AL355360.2, AL353593.3, AL160407.3, AL139003.1, AL035456.23, AC027605.4, AC018351.7, AC023277.3, AC067958.2, AC008723.5, ACOl 1418.3, AC018647.1, AC009333.8, AC026319.2, AC034141.2, AC018932.5, AC022469.3, AC025840.2, AC025144.2, AC026280.2, AC021774.3, ACOl 1029.3, AC015458.3, AC009545.3, AC024186.3, AC021011.2, AC021308.3, AC008519.2, AC015758.3, AC018790.3, AC012307.2, AC021333.1, AC018561.2, AC016110.1, AC006878.2, AL355540.1, AL354750.2, ALI39042.2, AL161444.2, AL136163.3, AL138719.1, AL137121.3, AP001638.1,

SEQ ID NO: 365

ZH085/T7

AC000015.2, U28371.1, AP001047.1, AC006101.3, AC009223.2, AL132979.2, AL031586.2, U29376.1, AB017066.1,

AC002337.2, AC008173.2, AC008124.8, AC005826.1, AL032657.1, U40938.1, AP000233.1, AB020878.1, AW003511.1, AA921845.1, AI652147.1 , AI693426.1, AI829962.1, AI434429.1, AA573137.1, AI332526.1, AH 83429.1, AI435449.1, Al 189561.1, AI378034.1 , AI221962.1 , N47325.1 , AWl 18897.1 , N41605.1 , N48812.1 , AW665247.1 , AW340077.1 , N29605.1, AA478519.1, AW190293.1, AA463875.1, AI292305.1, AA971089.1, AA463379.1, AA884954.1, AI858260.1, AI382934.1 , AA931835.1, AI125820.1, AI125702.1, AI358631.1, AI080245.1, AI027833.1, AW021929.1, AI399648.1, AA769041.1, AW372265.1, AA738261.1, N67374.1, AI014533.1, N69081.1, AA459715.1, AA347851.1, AW439905.1, D12465.1, AI768667.1, H88007.1, AA948472.I , D56771.1, AI819214.1, H22651.1, AA293133.1, H21980.1 , H42880.1 , H22650.1, AI186725.1, AA889214.1 , H88179.1, AI492769.1, D56772.1, H87354.1, D56691.1, H22043.1, H87486.1, AW628965.1, AA600109.1, AA574243.1, AI453007.1, AI222635.1, H16217.1, AW241802.1, AW083302.1, H25165.1, AA095911.1, H44052.1, AI376308.1 , H42946.1 , AW429971.1, AV346363.1, R34052.1, AW271826.1, AV366809.1, AV354759.1, AV344488.1 , AV298108.1, AVI 16868.1, R33250.1, AV355258.1, AV235683.1, AC010172.10, AC007511.2, AC013660.4, AC020193.1, ACOl 1 141.2, AC018353.10, AC068723.1, AC027044.2, AC025863.2, AC021531.3, AC013748.3, AL161932.4, AC022217.3, AC019U6.3, AC021362.4, AC021644.3, AC021159.2, AC017103.3, AC021986.1, AC010935.2, AC009741.4,

SEQ ID NO: 366 ZH1244 T3

NM_004719.1, AF147405.1, AC000015.2, AF030234.1, Y11251.1, U 16782.1, ALl 36419.2, ALU 1164.1, AE003490.1 , AF045341.1, AL121841.5, NC_001143.1, AC010283.5, AE003681.1, AF090924.1 , AC006389.2, AC003950.1 , AC004099.1, U16855.1, AL122013.3, Z69712.2, X76174.1, Z28239.1 , LI 1172.1, AB013190.1, D83502.1, AB000162.1, AW152460.1, AI969507.1 , AW084759.1, AI986247.1, AI81 1466.1, AI590951.1, AI984932.1, AI457465.1, T34545.1, AA903034.1, AI915886.1, AA938734.1, AA812235.1, AW083255.1, T68840.1, M79122.1, AI934225.1, AA376018.1, F13709.1, AI475277.1 , T68912.1, AA76781 1.1, T40900.1, AA103126.1, H30589.1, AW824184.1 , AW556003.1, AW228186.1, AW414066.1, AI098240.1, AV252704.1, AV321035.1, AI790543.1, AV319958.1, AW227799.1, AV356664.1, AA407099.1, AA871902.1, AA616747.1, AI108941.1 , AA140172.1 , AW611398.1 , AA836742.1, AA019444.1, AA012812.1 , AC010172.10, AC021642.1 1 , AC068273.2, AC061958.4, AC015669.4, AC022310.2, AC021978.4, AC016866.3, AC012445.3, AC020072.1, AP000799.1, AP000641.1, AC025652.2, AC069063.1 , AC016919.4, AC068892.1, AC010448.4, AC066310.1 , AC027233.2, AC021484.3, AC012246.3, AC022714.2, AC023929.2, AC022895.2, AC006583.17, ACOl 1966.2, AC013753.2, AC014256.1, AL137795.2, AP000941.2, AP000869.1 , AP000846.1 , AP000831.1, SEQ ID NO: 367 ZH1323/T3

NM_004719.1, AF030234.1 , Yl 1251.1, AC000015.2, U32169.1, U41066.1, AL031228.1 , AC006160.9, AL161537.2, AL035593.11 , Z97335.2, U97190.1 , AC004993.1 , AF004910.1 , AC005752.1 , AF048702.1 , AF047519.1 , AF047518.1, AJ249381.1, U39472.1 , L05083.1, L05082.1, L05081.1 , U17500.1, Z94043.1, Z99121.1, X02730.1, NC_001137.2, AC024756.1, AE003765.1, AC002406.1, U34874.1, U18530.1, U07562.1, AL050343.17, AL032640.1, Z29443.1, Z82270.1 , Z50858.1 , Z70225.1 , L42315.1, M63543.1 , M63544.1 , M27242.1 , L26545.1, AA319947.1 , AI538495.1 , AW835334.1, AW611398.1 , AW414066.1 , AA919730.1, AA571070.1 , AA103126.1, AA003764.1, W52849.1, AI504981.1, AA290444.1, AW271488.1, AW249666.1, AI681365.1, AI454944.1, AI273392.1 , AI251837.1, AI226601.1, W56462.1 , AW284526.1, AW236061.1, AV091886.1, C82282.1, C66973.1, N98074.1 , R04117.1, AC010172.10, AC064878.3, AL158134.5, AC068734.1, AC026445.2, AC046142.3, AC013546.3, AC068309.1 , AC068040.1 , AC026931.2, AC016388.2, AC044799.2, AC061962.1, AC013645.3, AC024422.2, AC021913.4, AC012203.4, AC013577.2, AL354739.3, AC025189.3, AC026470.3, ACOl 1320.7, AC068154.1, AC046192.1, AC025981.2, AC015916.3, AC025921.1, AC021002.3, AC016768.4, AC017029.4, AC013579.4, AC013777.3, AC025123.1, AC021754.3, ACOl 1330.5, AC020568.2, AC009213.4, AC023306.1, ACOl 1996.3, AC018467.3, AF127019.2,

AC014412.1, AC009707.2, AL035406.21, AL121876.26, AL355388.1, AP001562.1, AP001460.2, Z96103.1, AL031113.1,

SEQ ID NO: 368 ZH1406 T3 NM_004719.1, AF030234.1, Yl 1251.1, AC000015.2, U49056.1, AE003801.1, AE003791.1, AC008127.10, AF004910.1, AF030105.1, AF048702.1, AF047519.1, AF047518.1, AC004640.1, AL109938.8, AJ249381.1, AL022327.17, L05083.1, L05082.1, L05081.1, U17500.1, AP000003.1, Z94043.1, Z99121.1, X02730.1, U13618.1, NC_001140.2, AC009113.3, AE003442.1, AF189155.1, AC006552.7, AF085356.1, AC005599.5, AF093117.1, U23515.1, AC002350.1, U34874.1, U00027.1, AL163299.2, AL163261.2, Z97055.1, AL033127.1, L42315.1, J01323.1, U08988.1, AP001754.1, AP001716.1, AP001067.1, AP000188.1, AB023497.1, AP000043.1, AP000295.1, AP000112.1, AB018331.1, AW628965.1,

AW088601.1, AI453007.1, AI000658.1, AI922403.1, AW316950.1, AI935778.1, AA461606.1, AI084031.1, AW361894.1, AA384066.1, AA296633.1, AW083302.1, AA359862.1, AA359831.1, AA359605.1, AA319619.1, AW073290.1, AW241802.1, W52849.1, AA374554.1, AA867131.1, AI538495.1, AA459830.1, W08813.1, AW835334.1, C84289.1, AI990580.1 , AI352557.1 , H62920.1 , R91171.1 , AA574243.1 , AA692961.1, AA290444.1 , AA272113.1, AI462454.1 , AI120842.1, AW390895.1, AA093717.1, AI002763.1, AI524518.1, AA093740.1, AA003876.1, AI179529.1, AA600109.1, AW228936.1, T96952.1, AI426341.1, AI012492.1, AA359840.1, R91221.1, AW123947.1, AI152857.1, AI411610.1, AW525397.1, AI644515.1, W86494.1, AA901402.1, AA146549.1, H78241.1, AI504981.1, AA203781.1, AI154265.1, AA990247.1, AA003764.1, AI643169.1, AW802816.1, AW693307.1, AW476333.1, AW401588.1, AU074395.1, AI198894.1, AA326042.1, AA219378.1, R20933.1, R18569.1, AC010172.10, AL133159.3, AL133160.1, AC025996.3, AC068939.1, AC040935.2, ACOl 1398.4, AC016934.3, AC018412.3, AC009970.6, AC025215.1, AC022025.1, AC020112.1, AC017181.1, AC009522.2, AL355522.2, AL355360.2, AL161910.3, AL160407.3, AL138722.5, ALl 36125.2, AL035456.23, ALl 35909.3, AC068643.5, AC067731.3, AC026998.2, AC068642.2, AC023277.3, AC067958.2, AC008723.5, AC010315.4, AC016642.4, AC008538.4, AC008491.4, AC008461.4, AC032010.2, AC026319.2, AC012322.4, AC027501.2, AC068154.1, AC019172.3, AC009856.2, AC026988.2, AC018932.5, AC025840.2, AC025144.2, AC021606.3, AC034275.1, AC025931.2, AC021774.3, AC015458.3, AC024186.3, AC021002.3, AC021011.2, AC021308.3, AC008519.2, AC018790.3, AC021188.2, AC007603.1, AC017099.3, AC018561.2, AF214634.1, AC008130.5, AC016110.1, AC014356.1, AC009413.1, AC006878.2, AC003656.1, AL355611.2, AL355540.1, AL354750.2, AL139042.2, AL161444.2, AL138719.1, AL109948.2, AP001638.1, AP001452.1, AP001406.1, AP001271.1, AP001205.1, AP000896.1,

SEQ ID NO: 369 RPB-Jx

L07872.1, L34544.1, L34543.1, M81871.1, S63463.1, X17459.1, Z36843.1, NM_015874.1, L08904.1, D14041.1, L07873.1, L07876.1, X59130.1, U60094.1, U60093.1, X59129.1, M81869.1, L07875.1, L07874.1, X58337.1, M81866.1, M81870.1, M81867.1, M81872.1, M81865.1, M81873.1, M81874.1, AF100663.1, U49795.1, U49794.1, AE003646.1, AE003411.1, AF085173.1, AF047659.1, AB003695.1, AE002261.1, AE001663.1, AB035943.1, ACOl 1288.3, AC007729.2, AC002338.2, AE003505.1, AC006978.2, AE002049.1, AC005351.1, AF003130.1, Y08501.1, AL031680.17, Z93928.1, X66728.1, X65871.1, AJ007973.1, X69871.1, X58393.1, M94383.1, AC010682.2, AE003601.1, AC024864.1, AC024206.1, U09118.1, NM_001813.1, AC012329.3, AE002002.1, U22418.1, AC000100.2, AC000093.3, U50390.1, AF104919.1, AF015788.1, U57053.1, AC002375.1, AC002444.1, AL355836.1, AL161587.2, AL161492.2, AL132964.2, AL137898.1, AL132962.1, Z71185.1, S55498.1, AL035581.1, Z93385.1, Z81086.1, AL031785.1, AL035445.4, U70855.1, Z15005.1, AB027454.1, M81868.1, X60772.1, X96762.1, AL031135.1, AI325751.1, AW239382.1, AA101254.1, U69195.1, AA171575.1, AA081973.1, AA101350.1, AA332410.1, AI766488.1, T67576.1, T19153.1, D58647.1, AI190097.1, R44578.1, F01398.1, T23712.1, R37405.1, AA547961.1, AW462450.1, R30693.1, AW250553.1, T79039.1, T70135.1, AA935398.1, AA080102.1, AA429185.1, AW084668.1, AA817421.1, AI916589.1, AW801962.1, AW299030.1, AW250554.1, AH42713.1, AA971158.1, AA948444.1, AA736032.1, C12590.1, R71133.1, AW760949.1, AW619132.1, AW568358.1, AW567572.1, AW508325.1, AW493651.1, AW488718.1, AW488466.1, AW472135.1, AW471527.1, AW397878.1, AW397422.1, AW397379.1, AW390735.1, AW318250.1, AW307273.1, AW277776.1, AW221760.1, AW093987.1, AI995809.1, AV200012.1, AV198387.1, AV191304.1, AI846915.1, AU075765.1, AI779257.1, AU069114.1, C65393.1, AA203664.1, W90492.1, W84832.1, D73771.1, D69291.1, D68255.1, H66535.1, H66386.1, H49719.1, R00639.1, T95219.1, D48403.1, D48356.1, D37730.1, D22894.1, AL356136.1, AC044869.2, AC016175.1, AC006391.7, AC019747.1, AC026702.3, AC015644.3, AC015641.3, AC063967.1, ACOl 1359.3, AC025287.2, AC021871.7, AC024734.3, AC024447.2, AC021230.3, AC021195.3, AC017011.3, ACOl 1934.5, AC010780.3, AC025363.1, AC025099.1, AC013432.3, AC012096.7, AC010147.4, AC021313.1, AC013569.3, AC013105.1, AC006714.2, AL162291.7, AL353653.4, AP001377.1,

SEQ ID NO: 370

ZH121 T3

L07872.1, L34544.1, L34543.1, S63463.1, X17459.1, M81871.1, NM_015874.1, L08904.1, D14041.1, L07873.1, X59130.1, U60094.1, U60093.1, X59129.1, M81869.1, M81870.1, M81867.1, M81872.1, M81873.1, M81874.1, AE003646.1, AE003411.1, AF085173.1, AF047659.1, Z36843.1, AB003695.1, ACOl 1288.3, AC007729.2, AC002338.2, AC006978.2, AF100663.1, AF003130.1, Y08501.1, Z93928.1, U49795.1, X66728.1, X65871.1, AJ007973.1, X58393.1, M94383.1, AC010682.2, AF223391.1, AC024864.1, AC024206.1, NM_001813.1, AC012329.3, U22418.1, AC000100.2, AC000093.3, AF104919.1, AL355836.1, AL161587.2, AL161492.2, AL132964.2, AL137898.1, AL132962.1, AL035581.1, Z93385.1, Z81086.1, AL035445.4, U70855.1, U49794.1. Z15005.1, M81868.1. X96762.1, AL031135.1, AI325751.1, U69195.1, AW239382.1, AA081973.1, AA101254.1, T19153.1, AA101350.1, R44578.1, F01398.1, AA171575.1, T23712.1, R37405.1, AA332410.1, T67576.1, AW462450.1, T79039.1, T70135.1, AA935398.1, AA547961.1, AI766488.1, AA429185.1, AW084668.1, AA817421.1, AI190097.1, AI916589.1, AW801962.1, AI142713.1, AA736032.1, R71133.1, AW760949.1, AW221760.1, AW093987.1, AI995809.1, AV200012.1, AV198387.1, AV191304.1, AI779257.1, C65393.1, AA203664.1, C12590.1, W90492.1, W84832.1, D73771.1, D69291.1, D68255.1, H66535.1, H66386.1, H49719.1, R00639.1, T95219.1, D37730.1, AL356136.1, AC006391.7, AC016175.1, AC019747.1, AC015644.3, AC015641.3, AC063967.1, AC021871.7, AC024734.3, AC024447.2, AC021195.3, AC017011.3, AC010780.3, AC025099.1, AC010147.4, AC021313.1, AC013569.3, AC006714.2, AP001377.1, AC009716.3, AC055764.2, AC068491.1, AC068028.1 , AC005077.2, AC007273.3, AC008267.3, AC055790.1 , AC025889.2, ACO 16462.3, AC027268.1 , AC024560.4, AC022793.2, AC018681.5, AC022938.3, AC023815.2, AC013504.2, AC006904.2, AC006900.1, AC006719.1, AP001455.1, AP001445.1, AL009206.1,

SEQ ID NO: 371 ZH1255/T3

Z36843.1, L07876.1, L07873.1, L34544.1, L07872.1, L34543.1, NM_015874.1, L08904.1, D14041.1, M81871.1, S63463.1, X17459.1, L07875.1, L07874.1, M81866.1, X59129.1, U60093.1, U60094.1, X59130.1, M81867.1, M81865.1, AF100663.1, U49795.1, U49794.1, X58337.1, AE002261.1, AE001663.1, AB035943.1, AE003505.1, AC005351.1, X69871.1, AC010682.2, AC000100.2, U50390.1, Z71185.1, S55498.1, AL031785.1, AJ009961.1, AB005243.1, AI766488.1, AW239382.1, AA332410.1, D58647.1, AA171575.1, T67576.1, AI190097.1, AA547961.1, AA101254.1, AI325751.1, AA101350.1, R30693.1, AA081973.1, AW250553.1, T19153.1, AA080102.1, U69195.1, R44578.1, F01398.1, R37405.1, T23712.1, AW299030.1, AW250554.1, AA971158.1, AA948444.1, C 12590.1, A W390735.1, AI408535.1, AC044869.2, AC016175.1, AC006391.7, AL356136.1, ACOl 1359.3, AC025287.2, AC007037.3, AC021230.3, ACOl 1934.5, AC025363.1, AC013432.3, AC012096.7, AC013105.1, AL162291.7, AC009716.3, AC068641.3, AC018642.3, AC009783.6, AC023774.3, AC007273.3, AC027042.2, AC017098.2, AC022721.3, AC018525.4, AC024631.1, AC022321.3, AC016341.1, AL160011.4, AL138884.3, AL133240.1, AL121773.1, AP001445.1, AL008875.1,

SEQ ID NO: 372 ZH1314/T3

Z36843.1, L07876.1, L07873.1, L34544.1, L34543.1, NM_015874.1, L08904.1, D14041.1, L07872.1, M81871.1, S63463.1, X17459.1, L07875.1, L07874.1, X58337.1, X59129.1, M81866.1, X59130.1, U60094.1, U60093.1, M81865.1, AE003505.1, AE002049.1, AL031680.17, X69871.1, AE003601.1, AE003582.1, AE002261.1, AC004159.1, U09118.1, AC008047.3, AE002002.1, AC011622.4, AE001663.1, U50390.1, AFOl 5788.1, U57053.1, AC002375.1, AC002444.1, Z71185.1, S55498.1, AL031785.1, AL009175.1, AB027454.1, AB035943.1, X60772.1, AI766488.1, D58647.1,

AW239382.1, AI190097.1, AA547961.1, AA332410.1, AA171575.1, T67576.1, R30693.1, AW250553.I, AI325751.1, AA080102.1, AA101254.1, AA101350.1, AA081973.1, AW299030.1, AW250554.1, AW730270.1, AW727121.1, AW726947.1, AW619132.1, AW568358.1, AW567572.1, AW508325.1, AW493651.1, AW488718.1, AW488466.1, AW472135.1, AW471527.1, AW431366.1, AW397878.1, AW397422.1, AW397379.1, AW390735.1, AW318250.1, AW307273.1, AW277776.1, AW109344.1, AI846915.1, AU075765.1, AI731058.1, AI729101.1, AI726880.1,

AU069114.1, D48403.1, D48356.1, T19153.1, D22894.1, AC044869.2, AC016175.1, AC006391.7, AC026702.3, AC007256.2, AC021334.1, AC016185.1, AC068563.3, AC025765.3, AC008411.3, AC025363.1, AC013432.3, AC012096.7, AC013105.1, AL162291.7, AL353653.4, AC068951.1, AC026986.2, AC023250.3, AC027042.2, AC025941.2, ACOl 1571.3, AC013548.2, AC026266.1, AC024104.3, AC022321.3, AC012045.4, AC021459.1, AC018189.1, AC019977.1, AC009909.3, AC016341.1, AC012279.1 , ACOl 1252.3, AL159988.4, AL138884.3, AL138748.4, AL135920.5, AL133267.4, AL121944.14, AL135818.2, AL133153.1, AL008875.1,

SEQ ID NO: 373 ZH1314/T7 L34543.1, L07872.1, L34544.1, NM_015874.1, L08904.1, D14041.1, S63463.1, X17459.1, M81871.1, U60093.1, U60094.1, M81877.1, L07873.1, M81876.1, AE003830.1, AC005974.1, AL021578.1, AB024964.1, AB026048.1, AC012397.30, AC012147.7, AC007270.2, AC005839.1, AF049850.1, AF016494.1, D25323.1, X75598.1, D90170.1, D90168.1, M64933.1, AA641661.1, AW090508.1, AI627646.1, AI953614.1, AI962712.1, AI401150.1, AW131544.1, AA701607.1, AW302357.1, AI829826.1, AA501219.1, AA042864.1, AI984992.1, AA640106.1, AA903408.1, AA483607.1, AW249681.1, AW235086.1, AI381502.1, AA069672.1, AI619912.1, AI291840.1, AI023923.1, T67414.1, AI580826.1, AI375729.1, AI565611.1, AW425207.1, AI334962.1, AI334964.1, AI669755.1, N95392.1, AW005947.1, AI144435.1, AW815621.1, AI982567.1, AA788576.1, AA171398.1, F33435.1, AI631440.1, AA669918.1, AW815443.1, AA101255.1, AW391454.1, AA676341.1, AW815833.1, AA169326.1, AW815622.1, AA101351.1, AW391447.1, U69195.1, AW815635.1, AA908462.1, AA126685.1, AW815508.1, AW249892.1, AW801962.1, AW815506.1, AW815512.1, AW609613.1 , AA044415.1, AA678797.1, AW462450.1, AW381515.1 , AW474060.1, AW381537.1, AA156824.1, R12509.1, AW379059.1, AW371260.1, AI720441.1, AW189578.1, AW371378.1, T23713.1, AW381482.1, AW381510.1, AW381496.1 , AA705248.1, T70135.1 , R19314.1, AW381476.1, F05151.1, AI206928.1 , AW381459.1 , AW843169.1, AW610177.1 , AW393428.1, AW016196.1 , AW009270.1, AA092442.1 , R45471.1, H19326.1 , AI435870.1, AI274998.1, AI095803.1, AA235124.1, AA234950.1, W25228.1, AI919572.1, AW384329.1, AC006391.7, AC016175.1, AL356136.1, AC017078.3, AC017144.1, AL162420.3, AC051628.10, AC007849.6, AC068789.2, AC012480.4, AC009192.59, AC010552.3, AC022926.2, AC022391.2, AC015797.2, AL354999.1 , AL160035.3, AL159978.2, AP001532.1, AP001400.1, AP001005.1, AP000590.3, SEQ ID NO: 374 ZH1321 T3

L07872.1 , L34544.1, L34543.1, S63463.1, X17459.1, M81871.1 , NM_015874.1, L08904.1, D14041.1, L07873.1, X59130.1, X59129.1, U60094.1 , U60093.1, M81869.1, M81870.1, M81867.1, Z36843.1, M81866.1, AF100663.1, U49795.1, U49794.1, AE003646.1, AE00341 1.1, AF085173.1, AF047659.1, M81872.1, AB003695.1, ACOl 1288.3, AC007729.2, AC002338.2, AC006978.2, AF003130.1, Y08501.1, X66728.1, X65871.1, AJ007973.1, X58393.1, M94383.1, AC010682.2, AF223391.1, AC024864.1, AC024206.1, NM_001813.1 , AC012329.3, U22418.1, AC000100.2, AF104919.1, AL355836.1, AL136527.9, AL161587.2, AL161492.2, AL132964.2, AL137898.1, AL132962.1, AL035581.1, Z93385.1 , Z81086.1, AL035445.4, U70855.1 , Z15005.1, M81868.1, X96762.1 , AL031135.1, AI325751.1, AW239382.1 , AA101254.1, AA081973.1, U69195.1, AA101350.1, T19153.1, AA171575.1, R44578.1, F01398.1, T23712.1, AA332410.1 , R37405.1, T67576.1 , AA547961.1, AW462450.1, AI766488.1,

AA935398.1 , T79039.1, T70135.1, AI190097.1, AA429185.1, AA817421.I , AA080102.1, AI142713.1, AA971 158.1, AA948444.1, AA736032.1, C12590.1, R71133.1, AW760949.1, AW221760.1, AW093987.1, AI995809.1, AV200012.1, AV198387.1, AV191304.1, AI779257.1, C65393.1, AA203664.1, W90492.1 , W84832.1, D73771.1, D69291.1, D68255.I , H66535.1, H66386.1, H49719.1, R00639.1, T95219.1, D37730.1, AL356136.1, AC006391.7, AC016175.1, AC019747.1, AC015644.3, AC015641.3, AC063967.1 , AC025287.2, AC021871.7, AC024734.3, AC024447.2, AC021230.3, AC021195.3, AC017011.3, ACOl 1934.5, AC010780.3, AC025099.1 , AC010147.4, AC013569.3, AC006714.2, AP001377.1, AC009716.3, AC055764.2, AC068028.1, AC005077.2, AC007273.3, AC008267.3, AC055790.1, AC025889.2, AC016462.3, AC027268.1, AC018379.3, AC025135.2, AC024560.4, AC025141.2, AC022793.2, AC018681.5, AC022938.3, AC023815.2, AC013504.2, AC006904.2, AC006900.1, AC006719.1 , AP001575.1, AP001455.1, AP001445.1, AL009206.1,

SEQ ID NO: 375

ZH168/T3

Z36843.1 , L07872.1, L07876.1, L34544.1, L34543.1 , L07873.1, M81871.1, S63463.1, X17459.1, NM_015874.1, L08904.1, D14041.1 , L07875.1, L07874.1, M81866.1, X59129.1, U60093.1, U60094.1, X59130.1, M81867.1, M81869.1, M81865.1, X58337.1, AF100663.1, U49795.1, U49794.1, AE002261.1, AE001663.1, AB035943.1, ACOl 1288.3, AE003505.1, AC005351.1, X69871.1 , NM_001813.1, AC010682.2, U22418.1 , AC000100.2, U50390.1, Z71185.1 , AL031785.1, S55498.1 , Z15005.1, M81868.1 , AW239382.1, AA171575.1, AA332410.1, AI766488.1 , AA101254.1, T67576.1, AA101350.1, D58647.1 , AI190097.1, AA081973.1, AI325751.1, AA547961.1, T19153.1, R30693.1, R44578.1, U69195.1, F01398.1 , T23712.1, R37405.1 , AW250553.1, AA080102.1, AA429185.1 , AI585405.1, AA542353.1,

AW299030.1 , AW250554.1 , AA971158.1, AA948444.1, C12590.1, AW390735.1, AA203664.1, W90492.1, W84832.1, H66535.1, H66386.1 , H49719.1, R00639.1, T95219.1, AC044869.2, AC006391.7, AL356136.1, AC016175.1, AC026705.3, ACOl 1359.3, AC025287.2, AC021230.3, AC021195.3, AC013432.3, ACOl 1934.5, AC012096.7, AC025363.1, AC013105.1, AL162291.7, AP001377.1 , AC009716.3, AC040929.2, AC018642.3, AC009783.6, AC068028.1, AC023774.3, AC027042.2, AC007273.3, AC025496.2, AC022793.2, AC018681.5, AC022938.3, AC022321.3, AC016341.1 , AL138884.3, AP001445.1, AL008875.1

SEQ ID NO: 376 ZH1277/T3 NM_013285.1, L05425.1, U69600.1, AL034379.8, AB015478.1, X99436.1, AF076280.1, AC006920.10, AC004805.1 ,

AC007380.3, AF013149.1, AC007631.3, AF016485.1, AL137230.2, AL163241.2, AF016850.1, AL050403.13, Z50028.1, S75106.1, AP001696.1, AP001596.1, AW409934.1, AW245855.1, AW161434.1, AW163245.1, AA858436.1, AA316055.1, AA171883.1, AA308223.1, AW362598.1, AH 12354.1, AI573674.1, AA690847.1, AW326870.1, AA373618.1, AA352159.1, AU077157.1, AA989948.1, AW250083.1, H35016.1, AA686046.1, AA684606.1, AW245857.1, AW319272.1, AW765532.1, AV442312.1, AI994797.1, N38238.1, AW736578.1, AA068274.1,

AW174228.1, AI908898.1, AI657589.1, AI657580.1, T80141.1, AW838515.1, AW838503.1, AW738493.1, AV107331.1, AI482631.1, AA784611.1, AC023077.3, AC027731.2, AL355880.2, AC044835.2, AC040963.2, AC053546.3, AC010634.4, AC015533.4, AC064107.1, AC067611.1, AC056245.1, AC033416.1, AC027813.1, AC018624.3, AC025538.3, AC024646.2, AC024380.2, AL353692.3, AL138799.2, AL138841.1, AC027298.5, AC044833.2, AC068953.1, AC023151.3, AC018669.3, AC022164.4, AC009026.5, AC023374.2, AC009768.4, AC027006.2, AC026951.2, AC025065.2, AC009882.3, AC021409.3, ACOl 1012.3, ACOl 1693.4, AC018862.3, AC022052.2, ACOl 1860.3, AC016666.2, AC023958.2, AC010885.3, AC012206.3, AC013675.1, AC016064.1, AC009854.1, AL158042.3, AL136537.3, AP001589.1, AP001568.1, AP001401.1, AP001392.1, AP001281.1, Z93240.1 SEQ ID NO: 377 ZH131/T3

NM_013285.1, L05425.1, U69600.1, AL034379.8, ABO 15478.1 , X99436.1, AC024751.1, AC006920.10, AC004805.1, Z68325.1 , AP000067.1, AC007380.3, AF013149.1, AF016485.1, AL137230.2, AL163241.2, Z50028.1, Z97055.1, Z82204.1, S75106.1, AP001696.1, AP001596.1 , AK000019.1, AW245855.1, AW409934.1, AW161434.1 , AW163245.1, AA858436.1, AA316055.1, AA171883.1 , AA690847.1, AA308223.1, AW362598.1, All 12354.1, AI573674.1, AA373618.1, AW326870.1, AA352159.1 , AA989948.1 , AA684606.1, AU077157.1, AW250083.1, H35016.1, AA686046.1, AL024316.1 , AV125438.1, AW319272.1, AW245857.1, AW765532.1, H35824.1, AI853194.1, AA126101.1, AV125326.1, AV442312.1, AI994797.1, N38238.1 , T80141.1, AW736578.1, AW412154.1, AW377648.1, AW377646.1, AA930842.1, AA866918.1, AA717513.1, AA671873.1, AA272186.1, AA239193.1, AA210106.1, AAl 16767.1,

AA068274.1, AA060411.1, AA020022.1, AW174228.1, AI908898.1, AI657589.1 , AI657580.1 , R23322.1, AW738493.1, AV107331.1 , AI661426.1, AI482631.1, AC023077.3, AC027731.2, AL355880.2, AC006721.1, AC040963.2, AC024442.3, AC053546.3, AC064107.1, AC067611.1 , AC056245.1, AC033416.1, AC027813.1, AC024380.2, AL353692.3, AL138799.2, AL138841.1, AC013475.4, AC027298.5, AC044833.2, AC025258.4, AC023151.3, AC018669.3, AC022164.4, AC009026.5, AC023374.2, AC026277.3, AC026276.2, AC009768.4, AC027006.2, AC026951.2, AC025065.2, AC024191.3, AC023448.2, AC024531.2, ACOl 1012.3, ACOl 1693.4, AC018862.3, AC022052.2, ACOl 1860.3, AC016666.2, AC023958.2, AC021716.2, AC010734.3, AC013675.1 , AC016064.1, AL354855.3, ALl 36537.3, Z93240.1 SEQ ID NO: 378 ZH131/T7

NM_013285.1, L05425.1, AL034379.8, U69600.1, AE003547.1 , D49682.1, AC007211.5, AC007020.4, AC006200.2, AF085279.1, AL031635.1, AF235098.1, AE003829.1, AF125444.1, AL121748.6, AF016684.1, AL078468.1, Z72514.1 , AB021 155.1, AF176688.1, AE003738.1, AC002454.1, AL049710.18, ALl 10509.2, AW157242.1, AA902387.1 , AI628921.1, AI925558.1, AA401208.1, AW070650.1, AW162279.1 , AW409935.1, AA722289.1, AA126418.1, AW172793.1, AA857353.1, AA780182.1, AW156969.1, AI376281.1, AW183614.1, AI826742.1, AA582490.1, AI474094.1, AA446557.1, AA483614.1, AW246802.1, AA846248.1, AI253092.1 , AA934590.1, AA888018.1, AW804193.1, AI699045.1, AI867001.1, AA171554.1, AI95451 1.1, AI760439.1, AI763044.1, AI825244.1, AA126000.1, AW768894.1, AI671605.1, AW804232.1, AI702310.1, W81287.1, AA493881.1, AA863491.1, AW804255.1, AA766044.1, AA635139.1, AW804270.1, AA831455.1 , AWl 18384.1, AA659293.1, AA196109.1, AI244063.1, AA659297.1,

AI470650.1, AI798554.1, N32569.1, AA515590.1, AI245761.1 , AW002316.1 , AI9091 14.1, AW250835.1, AW362969.1, AA524198.1, T27737.1, AI345764.1 , AW301566.1, AI310849.1, AI310651.1, AW268086.1, AI589981.1 , AW268169.1 , AA056760.1, AW607751.1, AA614309.1 , A W529039.1, AH 12872.1, AI060050.1, AA546717.1, AW532741.1, AW557260.1, AV220510.1, AI646349.1, AI536459.1 , AI853259.1, AV090573.1, AI058723.1, AV310274.1, AW653179.1, AV236721.1, AV236719.1, AV167761.1, AV328006.1, AW111676.1, AV 153940.1, AA290477.1. AV31 1465.1 , AV296078.1 , AV225966.1, AV136397.1, AV232948.1, AV121458.1, AC027731.2, AL355880.2, AC023077.3, AC010058.5, AC013019.1, AC067926.1, AC068683.1, AC026348.2, AC022553.2, AC018707.5, AC023000.2, Z98865.1 , AC022165.3, AC022388.2, AC019056.4, AC016690.4, AC010732.3, ACO 15232.1 , ACO 10859.2, APOOl 150.1, AP000679.2, AC025097.8, AC062025.1, AC021296.2, AC024248.3, AF235096.1, AC009472.2, AC024127.1, AC016670.3, AC019749.1, AC009454.1, AL136116.2, AL136090.9

SEQ ID NO: 379

ZH1371/T3

NM_013285.1, L05425.1, U69600.1 , AL034379.8, NC_001 146.1, Z71668.1, AF124045.1, AFl 24739.1 , AFl 24737.1, AC010150.3, AL355632.1, AP000386.1, D89267.1, AC006200.2, ACOl 1664.8, AC009755.5, AF012277.1, U56240.1, U40940.1, M32885.1, AA126544.1 , AL135350.1 , AA303227.1, AA403201.1, AA446682.1, W79685.1, AW246249.1 , AW577783.1, AA692026.1 , AA475404.1 , AA451012.1, AA126101.1, AI907635.1, AA058438.1, AA821350.1, AI035443.1 , AA581348.1, AW427911.1 , AV138378.1, AW377646.1, AA271955.1, AW377648.1, W08841.1, AI763044.1, AA794525.1, AA320025.1, AI943334.1, AL024316.1, AV399123.1, AI974265.1, AI157210.1, AA120514.1, AW755414.1, AI166916.1, AW179912.1, AI181476.1, AV409400.1, AW649268.1, AW362969.1, AW093091.1, AI488290.1, AW002316.1, AI781856.1, AA373618.1, H35824.1, AW747374.1, AW146627.1, AW067567.1 , AW054133.1, AW017515.1, AI944299.1, AI184724.1, AA824259.1, AA399670.1, AC023077.3, AC027731.2, AL355880.2, AC018362.3, AL354981.1, AC024581.2, AC022120.4, AC016650.4, AC013658.3, AC012448.3, AL161648.5, AL139123.2, AC009780.4, AC067844.1, AC027070.2, AC040168.1, AC019089.3, AC021 109.2, AC024063.1, AC007495.3, AC023605.1, AL136959.2, AL138823.3, AL136104.3

SEQ ID NO: 380 ZH205/T3

NM_013285.1 , L05425.1 , U69600.1 , AL034379.8, ABO 15478.1 , X99436.1 , AC024751.1, AC006920.10, AC004805.1 , AC007380.3, AF013149.1, AF016485.1, AL137230.2, AL163241.2, Z50028.1, S75106.1, AP001696.1, AP001596.1, AW245855.1, AW409934.1, AW161434.1 , AW163245.1, AA858436.1, AA316055.1, AA171883.1, AW362598.1, AA308223.1, AH 12354.1, AA690847.1, AI573674.1, AW326870.1, AA373618.1, AA352159.1, AU077157.1, AA989948.1 , AA684606.1, AW250083.1 , H35016.1, AA686046.1 , AW245857.1, AW319272.1, AW765532.1, AL024316.1, AV125438.1, H35824.1, AV442312.1, AI994797.1, N38238.1, T80141.1, AW736578.1, AA068274.1, AW174228.1, AI908898.1, AI657589.1, AI657580.1, AW745332.1, AW738493.1, AV107331.1, AI482631.1, AC023077.3, AC027731.2, AL355880.2, AC006721.1, AC040963.2, AC053546.3, AC064107.1, AC067611.1, AC056245.1, AC033416.1 , AC027813.1, AC024380.2, AL353692.3, AL138799.2, AL138841.1, AC013475.4, AC027298.5, AC044833.2, AC023151.3, AC018669.3, AC022164.4, AC009026.5, AC027595.2, AC023374.2, AC026277.3, AC026276.2, AC009768.4, AC027006.2, AC026951.2, AC025065.2, ACOl 1012.3, ACOl 1693.4, AC018862.3, AC022052.2, ACOl 1860.3, AC016666.2, AC023958.2, AC010734.3, AC013675.1, AC016064.1, AL136537.3. Z93240.1

SEQ ID NO: 381 Ubiquitin-Specific protease (UBP)

NM_003368.1, AFl 17386.1, ALl 17575.1, AB014458.1, AE003523.1, AF069441.1 , AC006226.4, U14635.1, Z85995.1, AB006700.1 , AC006708.1, AE002611.1, AE001438.2, L29074.1 , AL133238.2, AL121985.13, AL049839.3, AL050322.10, AL109799.6, Z69730.1, AW340312.1 , AI911716.1, AW749359.1, AW601534.1, AW340211.1 , AW499935.1 , AI335992.1, H96555.1, AW304032.1 , AA749334.1, AI478913.1, AA779218.1 , AI656969.1, AA743294.1, AA577433.1, AA069285.1, AA952959.1 , AA016112.1, AA962284.1, AW089987.1, AA523181.1, AA723943.1, AA761280.1, AA0191 19.1, AW822658.1, AA413779.1, T55607.1, AA832380.1, AW525342.1, AW123839.1, AW592620.1, AA281098.1, AW182629.1, AA010709.1, AI071606.1, AI385272.1, AI008344.1, AI072340.1, AI001924.1, AA804171.1, AI716444.1, AW771501.1, AA361227.1, AA099033.1, D61597.1, AV310156.1, T09031.1, AW858821.1, AA921156.1, AV315746.1, AI050545.1, AA684326.1 , AW663812.1 , AA445060.1, AI040684.1, AI764163.1 , T34154.1, AA389075.1, AAl 10253.1, N50647.1, AW123867.1, AW121935.1, AI006640.1, AI006507.1, AA610647.1, AI815490.1, AV074783.1 , C96400.1, AA797782.1, AC025396.2, AL355389.1 , ACOl 1171.3, APOOl 167.1, AP000942.2, AC019070.2, AC027757.2, AC025742.4, AC010054.4, AC009375.5, AC014849.1, AP001112.1

SEQ ID NO: 382 ZH053/T3

NM_003368.1, AFl 17386.1, ALl 17575.1 , AB014458.1, AC003092.1, AC005488.2, NC_001138.1, AE003768.1, AE003752.1, AE003699.1, AE001438.2, AC005589.1, AC006035.2, AC008148.2, AC004527.2, AC006112.2, AC005146.1, AC004253.1, AL163204.2, AJ132695.4, AL009178.4, D50617.1 , AL031119.1, AL035563.18, Z69730.1, AL112201.1, AP001634.1, AB016897.1, J02714.1, M28060.1, D44599.1, AW601534.1, AW749359.1, AW499935.1, AI335992.1, H96555.1, AW304032.1 , AI911716.1, AA779218.1, AA577433.1, AA069285.1, AA952959.1, AW340312.1, AW340211.1, AA749334.1 , AA962284.1 , AI656969.1 , AA743294.1 , AW089987.1 , AAO 16112.1, AA523181.1, AA761280.1, AA0191 19.1, AW822658.1, AA413779.1, T55607.1, AI478913.1, AW525342.1, AW123839.1 , AW592620.1, AA281098.1 , AWl 82629.1, AI071606.1, AI385272.1, AI008344.1 , AA723943.1, AA010709.1, AI072340.1, AI001924.1, AA804171.1, AI716444.1, AA832380.1 , AA361227.1, D61597.1, AV310156.1, AW858821.1 , AV315746.1, AI040684.1, AI764163.1, AA610647.1, AW820736.1, AV074783.1, AV298047.1, AV130736.1 , AU074440.1 ,

AA299666.1 , N57436.1, N55027.1, D80851.1, H83754.1, H49832.1, R43246.1, R42769.1, T46940.1, AC025396.2, AL355389.1, AC019070.2, AC018465.3, AL355520.2, APOOl 112.1, AC025153.7, AC019059.3, AC027510.2, AC005236.3, AC018437.2, AL133270.19, AL138915.3, AL137222.3, AC023799.9, AC025996.3, AC053543.3, AC035142.2, AC010410.5, AC008899.4, AC024246.3, AC009412.3, AC055859.1, AC026145.2, AC026494.3, AC035892.1, AC007334.3, AC022200.2, AC008284.5, AC007223.1, AC010394.2, AC009586.3, AC009881.3,

AC020681.2, AC007855.4, AC017235.1, ACOl 7337.1 , AC007753.3, AL356123.1, AL355863.2, AP001004.2, AP001207.1

SEQ ID NO: 383 ZH053/T7 NM_003368.1, AFl 17386.1, ALl 17575.1 , AB014458.1, ALl 17503.1, X72910.1, AC026238.2, AE003461.1, AC004025.1, NM_011365.1, AFl 32480.1 , AFl 32479.1, AC005858.1, AF095792.1, AL078590.27, AL109628.2, ALl 17202.1, AL021476.2, AC022521.4, NC .001136.2, AC009415.2, AC004160.1, NM_008031.1, AC010200.7, AC002492.1 , AF131838.1, AF 126483.1 , AF007544.1, U66059.1, AC004100.1 , AC004223.1 , AF009660.1, AF035298.1, L36190.1 , AL121576.2, Z46792.1, AL133243.1, AL021940.1, U63063.1, Z74201.1, X97751.1, U07975.1, Z57476.1, L23971.1, AA628397.1, AA628438.1, AI743743.1, AI767389.1, AA741499.1, AA768854.1, AI677784.1 , AI765361.1, AI81 1418.1, AI627968.1, AA889584.1 , AA015599.1, AI435166.1, AW188257.1, AW181895.1, AW015219.1, AI090415.1, AI689149.1, AW301148.1, AI934936.1, AI000120.1, H81836.1, AA748367.1, AA804217.1, D79280.1, AI891 100.1, AA099034.1, AW016554.1, D62658.1, AA805297.1, AI698789.1, D79875.1, AA465112.1 , AW770219.1, AI337477.1, AW540444.1, AI848382.1, AW822264.1, AI681333.1, AW484136.1, AI186649.1, AI536041.1 , AA395995.1, AI934237.1, C85507.1, AW658316.1, D62657.1, AU016813.1, AA965253.1, AI010241.1, AU022718.1, AI467289.1, AU016862.1,

AI846844.1 , H81837.1 , AW681682.1 , A W359811.1 , AA839561.1 , AA636424.1 , AA472594.1 , AAl 38196.1 , A W486007.1 , AW321832.1 , AA390042.1 , AI030804.1 , AV222579.1 , AV276289.1 , AV273007.1 , AVO 16369.1 , AVO 10041.1 , AV312954.1, AV309927.1, AV228458.1, AV266855.1, AV220500.1, AV273264.1, AV271972.1, AV254845.1, AV240341.1, AV229917.1, AV254525.1, AV235477.1, AV275335.1 , AV157245.1, AV268617.1, AV254319.1 , AV237589.1, AV220743.1, AV312158.1 , AV240296.1, AV350107.1, AV305966.1, AV312731.1, AV276116.1, AV271062.1, AV254741.1 , AV247868.1, AV369945.1, AV030917.1, AV234637.1, AC025396.2, AL355389.1, AC022415.4, AC012618.3, AC062036.1, AC034113.2, AC008110.2, AL353735.2, AL355599.2, AC012439.4, AC019288.3, AC016766.3, AC020522.1, AL121952.6, AC055779.2, AC010404.3, AC010465.4, AC068504.1, AC027716.2, AC022458.2, AC027000.2, AC025482.2, AC022931.3, AC015881.3, AL138836.3, AL162551.1 SEQ ID NO: 384 ZH1313/T3

NM_003368.1, AFl 17386.1, ALl 17575.1, AB014458.1, AE003523.1, AF069441.1, AL161500.2, AL032655.1, AL133421.1, Z85995.1, Z94721.1, AC006708.1, AE002611.1, AC008148.2, L29074.1, AC006060.1, AL133238.2, AL133372.2, AL121985.13, AL050322.10, AI478913.1, AW340312.1, AW340211.1 , AW771501.1 , AA832380.1, AA749334.1 , AA743294.1 , AI911716.1 , AI656969.1 , AA723943.1 , AA099033.1 , T09031.1 , AA921156.1 , AI050545.1 , AA684326.1, AW663812.1, AA445060.1, AA0161 12.1, AW749359.1, AA010709.1, AW601534.1, AI764163.1, T34154.1, AA389075.1, AAl 10253.1 , N50647.1, AW123867.1 , AW121935.1, AI006640.1 , AI006507.1, AI815490.1, AV074783.1, C96400.1, AW605305.1, AW605290.1, AW485355.1, AV334525.1, AV316977.1, AV271577.1, AV27101 1.1, AI925190.1 , AI880405.1, AV089080.1, AU053253.1, AI601868.1, AI577543.1, AI568768.1, AI416338.1, AI354858.1, AI132532.1, AA797782.1, AA789662.1, AA418927.1, AA242816.1, AA007209.1, N75527.1, N26669.1, H44548.1, T50640.1, AC025396.2, AL355389.1, ACOl 1 171.3, APOOl 167.1, AP000942.2, AC027757.2, AC025742.4, AC010054.4, AC009375.5, AC014849.1, AC022172.4, AC026984.1, AC006839.13, AL136322.2, AC026084.2, AC010594.4, AC008504.4, AC027800.2, AC027392.2, AC021514.3, AC025821.2, AC009578.3, AC021258.3, AC018491.7, AC012545.1 , AL136442.10, AL139406.2

SEQ ID NO: 385 ZH1313/T7 NM_016520.1, AF218421.1 , AF151054.1, AL137549.1, AL008726.1, AL163249.2, AC010620.4, AC008044.4,

AC002377.1, AC004921.1, AC004383.1, AL163212.2, AL096801.18, Z96074.4, Z84483.1, AP001667.1, AP000962.2, AC006055.1, AL163262.2, Z98036.1, AP001717.1, AP000191.1, AP000047.1, AP000115.1, AC006511.5, AC005089.2, AC005145.1, AL022316.2, AC006344.2, AF001550.1 , AL078463.1 1, AP000348.1 , AC0O4024.1, AC004076.1, AL135998.2, AL133448.3, AJ003147.1, AC004000.1, AC004491.1 , AC007308.13, AC006251.3, AL023553.5, AP000509.1, AC010491.3, AC005086.2, AF139813.1 , AC004228.2, AC005755.1, AL163953.2, U50871.1, AL121580.8, AL033521.2, AC005231.2, AC004913.2, AC007360.2, AC007435.12, AF035396.1, AL121751.12, Z82215.1 , AP000049.1 , AP000311.1, AC006464.3, AC006349.3, AC004850.2, AC006317.3, AC004997.2, AC007229.1, AC006958.1, AC005562.1, AC005220.1, AL109627.18, AJ251973.1, AL008582.1 1, AL021453.1 , Z92542.2, AL031311.1 , ACO 18769.2, AC004999.1, AC009405.3, AC002554.1, AC002558.1, AL161670.2, AL031296.1, AC008969.5, U96629.1, AL157915.2, AC004150.8, AC005808.1, AL021393.1, Z82206.1, AP000555.1, AL132986.2, Z97630.1 1, AL096776.12, AP000212.1, AP000134.1, AC004531.1, D83253.1, AP000009.2, AL031767.13, AI141544.1, AI651600.1, AI376077.1, AA503812.1, AA516476.1, AI458346.1, AI052479.1, AI146331.I , AI695736.1, AI812016.1, AI863150.1, AI214622.1, AI002868.1, AA639060.1, AI057130.1, AI913816.1, AI686336.1, AI685712.1, AI686315.1, AA503513.1, AA31 1466.1, AI765330.1, AI917006.1, AA934021.1, AW589928.1, AI763234.1 , AW023167.1, AA761722.1, W80591.1, AA470915.1, AW088965.1, AA579082.1, AA522864.1, AA156183.1, AA155817.1, W69639.1 , N99245.1, AI459879.1 , AW608403.1, AW162762.1, F00937.1, AW392038.1, AA132445.1, AW795901.1, D44871.1, W78986.1, AI242236.1, AI520984.1 , AW388476.1 , H89643.1, AW078646.1, AW072963.1, AI444575.1, AI344906.1, AI318548.1, AA505108.1, R87193.1, AW504667.1, AI917132.1, AI523356.1, AA947352.1, AA489939.1, AI699746.1, AA015948.1, W60000.1 , W03800.1, AW247866.1, AI003391.1, AA663579.1, AL138226.1, AL044701.1, AW779609.1, AW131394.1, AW105463.1, AI918350.1, AI754257.1, F35684.1 , AI631299.1, AI277617.1, AA664963.1, AA633804.1, AA595370.1, AA576672.1, T99365.1, T52366.1, T40388.1, AW419288.1, AI702018.1, AA573335.1, AA526529.1, N72195.1, T71936.1, AI791664.1, AI654336.1, AA348890.1, AI809776.1 , AA287363.1, AA569648.1, AA230203.1, AA419403.1, AC027008.2, AL158207.3, AC016109.3, AL138963.4, ACOl 1638.3, AC02121 1.2, AC021055.6, AC012014.4, AC021026.3, AC018356.7, ACOl 1448.2, AC020561.2, AC023268.2, AP000761.1, AL109932.2, AC044812.2, ACOl 1501.5, ACOl 1495.3, AC021420.3, AC019162.3, AC024944.2, AC026192.1, AC010130.4, AL353653.5, AL133230.19, AC022145.4, AC017008.4, AL136135.2, AC023271.3, AC0O4085.1, AL354935.3, AC010247.6, AC021971.3, AC009008.2, AL139398.2, AL139109.1, AC068707.2, AC035146.2, AC027342.2, AC008784.5, AC020931.3, AC025163.7, AC008551.3, AC025370.2, AC021469.3, AC009996.3, AC023201.2, AL161787.4, AC008053.2, AC009863.2, AC013421.5, AC009027.4, AC007256.2, AC055774.1, AC007912.4, AC024583.3, AC027474.2, AC024051.3, AC022021.2, AC016124.2, AL138810.6, AL136097.10, AC013446.3, AC024582.3, AC025162.7, ACOl 1498.4, ACOl 1480.2, AC024045.3, AC015945.3, AL161736.5, AL356140.1, AL355978.1, ALl 10504.2, AP000597.1, AC020558.3, AC021187.4, AC008032.12, AC019131.3, AL158156.3, AL136233.3, AL031711.23, AC027178.3, AC010264.4, AC067910.1, AC027250.2, AC062024.1 , AC016385.3, AC005995.2, AL159993.3, AL160171.2, AP001084.2, AC022766.2, ACOl 1511.4, ACOl 1486.5, AC009127.5, AL121914.20, AL161778.2, AP001075.2, AC007616.2, AC068603.1

SEQ ID NO: 386 ZH1373 T3

NM_003368.1, AFl 17386.1 , ALl 17575.1, AB014458.1, AF069441.1, AL161500.2, AL032655.1, AF108240.2, AF108239.2, AF108238.2, AF108332.1, AF108331.1 , AF108330.1, AF108329.1, AF108328.1, AF108327.2, AF108326.2, AF108325.1, AF108324.1 , AF108323.1, AF108322.1, AF108321.1, AF108320.1, AF108319.2, AF108318.1, AF108317.1 , AF108316.1 , AF108310.1, AF108309.2, AF108308.1 , AF108303.2, AF108302.1, AF108299.2, AF108298.1 , AF108295.1, AF108294.1, AFl 08291.1 , AFl 08290.2, AF108289.1, AF108285.2, AF108283.1, AF108279.1, AF108276.1, AF108275.1, AF108271.1 , AF108270.1, AF108266.1, AF108258.1 , AF108256.1, AF108255.1, AF108251.1, AF108250.1 , AF108249.2, AF108245.1, AF108243.2, AF108242.1, AF108236.2, Z85995.1 , AC006708.1, AE00261 1.1, AF005090.1, L29074.1 , AC007436.1, AL133238.2, AL050322.10, AL080318.1, X75560.1, AI478913.1 , AW340312.1 , AW34021 1.1 , AW771501.1 , AA832380.1 , AA749334.1 , AA743294.1 , AI911716.1 , AI656969.1 , AA723943.1 , AA921 156.1 , AA099033.1, AI050545.1 , AA684326.1, AW663812.1, AA445060.1, T09031.1, AW749359.1, AA0161 12.1, AI764163.1 , AA010709.1, AW601534.1, AA389075.1, AAl 10253.1, N50647.1, AW295263.1 , AI954652.1. C96400.1, AI203173.1, AW485355.1, AV334525.1, AV316977.1, AV271577.1, AV271011.1, AI880405.1, AV089080.1, AU053253.1 , AI601868.1, AI577543.1, AI416338.1, AI416266.1, AH32532.1, AA242816.1, AA007209.1, N26669.1, H44548.1, AC025396.2, AL355389.1 , AC027757.2, AC025742.4, AC010054.4, AC009375.5, AC014849.1 , AL022597.5, AL022596.1, AC022172.4, AC023271.3, AC010189.3, AC006839.13, AL121935.15, AC010269.3, AC010594.4, AC015549.4, AC027012.2, AC021514.3, AC009578.3, AC013697.3, AC021258.3, AL159984.3, AL136442.10, ALl 39406.2

SEQ ID NO: 387

Novel DNA Binding Protein SON AB028942.1, AL163262.2, AP001717.1 , AP000190.1, AP000046.1, AP000303.1, APOOOl 14.1, X63071.1, NM_003103.1, X63751.1, X63753.1, M36428.1, AF193607.1, AF193597.1, AF096370.1, U67523.1, AL161492.2, AC007444.1, AE003698.1 , AC004922.2, U61957.2, AE000616.1, AL021069.1, X60091.1, AE003578.1, ACOl 1594.8, AC010186.6, AF160183.1, AC006560.8, AC007486.1, U20864.1, AC004279.1 , AC005360.1, AL161509.2, AL138664.1, Z81583.1, Z97183.1, Z99290.1, AL078630.1 , Z83087.1, AW500791.1, AI093497.1 , AA664291.1, AA789090.1, AW173628.1, AI858858.1, AW440738.1, AI656181.1, AW162728.1, AW168833.1, AAl 15678.1, AW079444.1, AA627614.1,

AW025637.1, AW502403.1 , AI702294.1, AA1721 13.1, AI801337.1, AA092460.1, AL046209.2, AA036700.1, W79819.1, AW073811.1, AI610270.1, AA063617.1, AAl 55757.1, AA568211.1, AI905785.1, AI905720.1, AI854469.1, AI585864.1, AA647960.1, C76879.1, AA779531.1, AI561366.1, AA880031.1 , AI874007.1, AW209037.1, AA654021.1 , W02066.1, N25237.1 , AW709451.1, AW382784.1, AW255430.1, AU074816.1, AI645064.1, AU038934.I , C96900.1, T24344.1, T24239.1, AC023286.1, AC025147.2, AC026052.2, AC009337.1 , AC012151.5, AC021710.4, AC020159.1, AC009393.3, AL109926.2. AL159988.4

SEQ ID NO: 388 ZH122 T3 AB028942.1, AL163262.2, AP001717.1, AP000190.1, AP000046.1 , AP000303.1, APOOOl 14.1, X63071.1, NM_003103.1, X63751.1 , X63753.1, M36428.1, AF193607.1, AF193597.1, U67523.1, AC007444.1, AE003698.1, AC004922.2, U61957.2, AE000616.1 , AL021069.1, X60091.1, AE003578.1, AC006560.8, AC007486.1, U20864.1, AC004279.1, AL138664.1, Z81583.1, Z97183.1 , AL078630.1, AW500791.1, AI093497.1 , AA664291.1, AA789090.1, AW173628.1, AI858858.1, AW440738.1, AI656181.1, AW162728.1, AW168833.1, AAl 15678.1 , AW079444.1, AA627614.1, AW025637.1, AW502403.1, AI702294.1, AA1721 13.1, AI801337.1, AA092460.1, AL046209.2, AA036700.1, W79819.1, AW073811.1 , AI610270.1, AA063617.1, AAl 55757.1, AA568211.1, AI854469.1, AI585864.1, AA647960.1, C76879.1 , AA779531.1, AI561366.1 , AI874007.1 , AA880031.1, AW209037.1 , AA654021.1, W02066.1 , N25237.1 , AW709451.1, AW255430.1, AU074816.1, AU038934.1, T24344.1, T24239.1, AC023286.1 , AC020159.1, AC009393.3, AL109926.2, AL159988.4, AC006431.8, AC037431.3, AC068960.1, AC016481.4, AC020783.5, AC034225.3, AC022128.4, AC022101.3, AC022091.3, AC010309.4, AC008790.4, AC008453.4, AC032028.2, AC022032.2, AC034209.1, AC025961.2, AC025589.6, ACOl 1804.2, AC022731.2, AC005506.6, ACOl 1799.5, AC022673.3, AC018535.3, AC023630.3, AC012584.5, AC022404.4, AC018388.4, AC012283.2, AC006513.24, AC020062.1, AC021612.1, AC015716.2, AL109933.20, AL136179.10, ALl 17346.16, AP002077.1, AP001899.1, AP001891.1 , Z93340.1, Z92853.1 SEQ ID NO: 389 ZH122/T7

AL163262.2, AP001717.1, AP000191.1, AP000046.1, AP000304.1, APOOOl 15.1, NM_003103.1, X63753.1, X63071.1, X71604.1 , X63754.1, S79056.1 , AF193606.1, S79073.1, S79065.1, S79I 73.1, S79122.1, S79121.1, AC009948.3, AE003585.1, AE003488.1, AC004991.1, AF060492.2, AC003945.1, ALl 63229.2, AL049833.3, Z75741.1 , AP001684.1, AP000953.2, AP000399.1, AC006931.5, AF130357.1, AC004843.1, AC006036.3, AF139813.1, AC004228.2,

AC005755.1 , AF086106.1, AC003025.1, AF053468.1, AL161545.2, AL032632.1, AL021331.1, Z97343.1, Z97342.2, AJ131244.1, AP000364.1, U12660.1, AB020742.1, M57403.1, AI127294.1, AW183190.1, AW057768.1 , AI986205.1, AI632353.1, AI829400.1, AW009915.1, AA004621.1, AI689364.1 , AI023134.1, AA993267.1, W93400.1, AW071490.1, AI018093.1, AW166988.1, AW6281 18.1, AI143809.1, N53353.1, AI266546.1, AA857332.1, AI223425.1, AA772726.1, AI719242.1, W72973.1, AW304836.1, AW243063.1, AAl 35743.1, AI768842.1, AA872747.1, AH 49578.1, AI038972.1, AI371983.1, AI200398.1, AI658892.1, AI572963.1, AI079652.1, Al 183623.1 , AA772215.1, AI034430.1 , AI471859.1, AI148234.1, AI091926.1, AW081281.1, AI707914.1, AA431849.1, AA257112.1 , AI358802.1, AI161381.1, AI270200.1, AA694295.1, AW001009.1, AA679405.1, AA837277.1 , N70647.1, AA693673.1, AA133200.1, AA032186.1, AI051633.1, D20101.1, AA992481.1, AW089317.1, N24069.1, AI087419.1 , AA707015.1 , AA844291.1, W02725.1 , F03502.1, AA225330.1, AI300124.1 , T24029.1, W19535.1, H10383.1, AI471076.1, AA225331.1, N50988.1, H99525.1, AA852180.1, AA580105.1, N44831.1, AI369509.1 , AI300125.1, D56905.1, AA771805.1 , AA011291.1, AI445493.1, AI0441 12.1, H53644.1, AI411504.1 , R42100.1, AW148843.1 , R41991.1, W27063.1, AA890446.1, AL040534.1, AI018814.1, AA278461.1 , AW520510.1, AI461608.1, AI426368.1, AW543039.1, AC015861.5, AC023312.2, AC009883.3, AC015624.2, AC060792.2, AC061971.2, AC025469.3, AC020914.6, AC008750.6, ACOl 1490.4, AC010973.3, AC026497.1 , ACOl 1068.7, AC023217.2, AC020488.1, AC017153.1, AC015894.2, AL135793.5, AC068802.3, AC063957.6, AC010636.5, AC008554.6, AC063950.2, AC010301.4, AC051664.2, AC013455.3, AC010095.3, AC048365.1, AC021218.3, AC025473.2, AC021965.3, AC019311.4, ACOl 1954.5, AC012400.4, AC010754.2, AC018955.2, AC022636.3, AC018584.3, AC024480.2, AC024387.2, AC010910.6, AC018377.4, AC023989.2, ACOl 1025.4, AL136384.3, AL353153.2, AL138724.2, AL139319.4, AL354869.1 , AP001947.1, AP001823.1 , APOOl 199.1, APOOl 164.1, AP000766.1

SEQ ID NO: 390 ZH1387/T3 AL163262.2, AP001717.1, AP000190.1, AP000046.1, AP000303.1, AP000114.1, X63071.1, AB028942.1, NM_003103.1, X63751.1, X63753.1 , AF193607.1, AF193597.1, AF096370.1, AL161492.2, AC007444.1, AE003698.1, X60091.1 , ACOl 1594.8, AC004988.2, AC010186.6, AF160183.1, AC005360.1, AL161509.2, Z81555.1, Z97183.1, Z99290.1, Z83087.1, AW500791.1, AI093497.1, AA664291.1, AA789090.1, AI905785.1, AI905720.1, AW173628.1, AW440738.1, AI858858.1, AW162728.1, AA880031.1, AA036700.1, AI656181.1, AI585864.1, AW168833.1, AAl 15678.1, AI854469.1, AA627614.1, AL046209.2, N25237.1, AW382784.1, AW255430.1, AI645064.1 , C96900.1 , W79819.1, AC023286.1, AC009771.4, AC025147.2, AC026052.2, AC009337.1, AC012151.5, AC021710.4, AC020159.1, AC009393.3, AC010854.3, AC020783.5, AC034225.3, AC027332.2, AC022128.4, AC022101.3, AC008639.6, AC008790.4, AC032028.2, AC024035.3, AC022032.2, AC034239.1, AC032032.1, AC015514.3, AC025788.2, AC012269.2, AC022731.2, AC025142.2, AC022810.3, AC020776.3, AC016378.4, AC012587.4, ACOl 1799.5, AC021009.3, AC021065.3, AC024007.2, AC012584.5, AC006513.24, AC022814.1, AC021921.1, AC021612.1, AC015716.2, AC012430.2, ACOl 1968.1, AL136999.17, AL355612.2, AL355350.1, AL136179.10, AL138849.5, ALl 17346.16, AP002077.1, AP001891.1, AL049185.4, AP001087.2, AP001275.1, AP001272.1, APOOl 176.1

SEQ ID NO: 391 ZH1387/T7

AL163262.2, AP001717.1, AP000191.1, AP000046.1, AP000304.1 , AP000115.1, NM_003103.1, X63753.1, X63071.1, X71604.1, X63754.1, AF193606.1, S79056.1, S79065.1, S79073.1, S79173.1 , AC006036.3, AC005755.1, AJ131244.1, AW304836.1 , AWl 66988.1, AI719242.1, AH 27294.1, AI038972.1, AWl 83190.1, AI658892.1, AI371983.1, AI632353.1, AI270200.1, AI091926.1 , AA772215.1, AA431849.1, AW081281.1, AI829400.1, AW057768.1, AI572963.1, AA032186.1, AW009915.1, AI986205.1, AI087419.1, AA133200.1, AA225330.1, AI689364.1, AI300124.1, AI023134.1, AA993267.1, W19535.1, AI300125.1 , AA852180.1, AA004621.1, AA844291.1, T24029.1, AA857332.1, N44831.1, AW071490.1 , AI018093.1, W72973.1, AA771805.1 , AI143809.1, AW6281 18.1, AA872747.1, AA225331.1, N50988.1, AI768842.1, AI266546.1, AA772726.1, W93400.1, AW243063.1, AI223425.1, AI149578.1, AI034430.1, AA135743.1, AI200398.1, N53353.1 , AH 83623.1 , AI707914.1 , AI369509.1 , AI079652.1 , H53644.1 , AI471859.1 , AA257112.1 , Al 148234.1 , N70647.1, AI358802.1, AI161381.1, AA693673.1, W27063.1, AA837277.1, AA694295.1 , AA679405.1, AW001009.1, AI051633.1, AL040534.1, R42100.1, D20101.1, AA992481.1, D56905.1 , AA278461.1, R41991.1 , AW089317.1, AW148843.1 , W76210.1. N24069.1, AA707015.1, F03502.1 , AW024013.1, W02725.1 , AU059172.1, AW520510.1 , AI044U2.1, AI471076.1 , AA58O105.1, H10383.1 , AW838467.1, AI41 1504.1, H99525.1, AA011291.1, AA914126.1, AA763747.1, AC026497.1, AC010301.4, AC024387.2, AL353760.2, AL139410.2

SEQ ID NO: 392

Carboxyterminus HSP70 (CHIP)

AF129085.1, NM_005861.1, AF039689.1, Z92544.1, AF129086.1, Z46940.1, NM_015185.1, AE003761.1, AF003630.1,

AF003629.1, U85251.1, U85040.1 , U85039.1, AB007884.1, AC016951.9, NM_006114.1, NM_006326.1 , AC007406.1, M60319.2, AF050154.1, AF043251.1, AF043250.1, AC005296.1 , AC005696.1 , AL050075.1, AL021391.2, AJOl 1716.1, AL021899.1, L19655.1, M93129.1, Y18007.1, M73822.1, M62862.1, NM_013379.1, NM_015456.1, AC007968.3, AE003655.1, AE003552.1, AE003445.1, NM_011258.1, NM_006081.1, NM_004608.1, AF154502.1, AF038163.1, AF091504.1, AF030050.1, U07157.1, AF059678.1, AC003663.1, AJ002220.1, U15037.1, AL050280.1, AL137480.I , AL031595.4, AL034379.8, Z98742.5, X06542.1, U53344.1, AJ007989.1, M88489.1, U36441.1, X72711.1, D17315.1, M73980.1 , X75917.1 , Z63970.1 , AB002354.2, J05475.1 , Z58600.1 , Z64961.1 , Z57538.1 , AB023231.1, X56659.1 , D78638.1, L10425.1 , U01222.1, AI630895.1, AI971879.1, AW074238.1, AA573790.1, AI097431.1, AI732281.1, AA775749.1, AI133167.1, AI476536.1, AW272212.1 , AI313142.1, AW074246.1, AA523100.1, AI922522.1 , AA977131.1, AI567504.1 , AI800972.1, AW519276.1 , AW007382.1, AI265896.1, AA707243.1 , AI186162.1, AA156751.1, AA872941.1, AA988951.1 , AW780114.1, AA196335.1, AA777058.1, AI040100.1, AI095230.1 , AI193384.1, AI884857.1, AI147782.1, AI084116.1, AI186356.1, AAl 56923.1. AI263601.1, AA916340.1, AAl 26861.1, AAl 14904.1, AAl 13285.1, AI367545.1 , AI248132.1, AI350140.1, AI265894.1, AAl 13175.1 , AW392245.1, AW134969.1, AI241250.1, AI829488.1 , AW769510.1, AW800139.1, AL045313.1, AA604290.1, H46715.1, R44011.1, T35752.1, AA081740.1, AA975174.1, AI801581.1 , AA913651.1 , AA100870.1, N44930.1, AW410549.1, AA358373.1 , AI857353.1, F37468.1, N48716.1, AAl 14903.1, T31912.1, AAl 27292.1 , AI820702.1 , Wl 9324.1 , AI954554.1 , AW602696.1 , AW229260.1 , AA431375.1 , F36498.1 , AA195861.1 , H46168.1, AI930417.1, AI250171.1, AI799945.1, F31326.1, AI270045.1, R73332.1, H46782.1, AI971264.1, AW083927.1, R40538.1 , AA034510.1, AA377856.1, AI670750.1, AA369419.1, R54831.1 , N45564.1 , T03682.1, R46339.1 , AA838975.1, AA161201.1 , AC068332.1, AC016209.3, AC007818.6, AC023027.1, AC012366.3, AC013071.1, AL355142.1, AC021051.3, ACOl 1847.3, ACOl 1088.8, ACOl 1556.5, ACOl 1531.6, ACOl 1481.2, AC022266.3, AC020772.3, AC009433.2, AC012122.2, AC021988.3, AC021830.5, AC018775.3, AC022408.3, AC021753.3, AC016796.2, AC016741.2, AC024694.1, AC021051.2, AC022155.1, AC012116.1, AP000795.1

SEQ ID NO: 393 ZH037/T3 NM_016195.1 , AL137392.1, ALl 17496.1, U67547.1 , U07563.1 , AL139077.2, AJ012549.1, AJ012548.1 , AJ131631.1, AJI31605.1 , AJ131604.1, AJ006413.1, AC005517.6, AC007538.5, AL161580.2, AL161553.2, Z81308.2, U80842.1, AL080253.2, Z35983.1 , Z35981.1 , X78993.1 , X66247.1 , M86929.1 , M23440.1 , AE003619.1 , AC005826.1 , AE003777.1 , AC003078.1, AF080676.2, AF121877.1, U14635.1, AL033514.1, AI207433.1, AW087682.1, N27428.1, N91 105.1, AW073910.1, N63752.1, AW804880.1, AV167631.1, AI050668.1 , AU043551.1, AU043451.1, AW575801.1, AW332046.1 , AWl 86938.1, AI943584.1, AI556638.1, AA598340.1, AW826622.1, AW642869.1, AW429262.1, AW429260.1, AW264218.1, AW264313.1, AV267378.1 , AV266927.1, AV261836.1, AV383573.1, AW077965.1, AW059145.1, AW050948.1, AW002731.1, AI991076.1, AI959674.I , AI895859.1, AI884592.1, AI865631.1, AI864349.1, AI851787.1 , AI830437.1 , AI830001.1, AI826534.1, AI806788.1 , AI796066.1 , AI769520.1 , AI764991.1, AI739031.1, AI694336.1, AI688370.1, AI659991.1, AI636072.1 , AI523645.1, AI446795.1, AI376598.1, AI168732.1, AI151708.1, AH 23957.1 , AI092234.1 , AI060045.1 , AA981087.1 , AA835447.1 , AA805323.1 , AA767572.1 , AA736849.1 , AA622266.1 , AA477542.1 , AA460997.1 , AA453387.1 , AA434777.1 , AA260524.1 , AA253431.1, AA211867.1 , AA209000.1 , AA154452.1, AA142890.1, AA059694.1, AA050064.1, N31935.1, N20982.1, H27300.1, R77327.1, R48581.1, R28039.1, AL157389.3, AL161733.3, AL353776.3, AC064835.3, AC007569.7, AC022888.2, AC015047.1, AL355489.4, AL354658.2, AP001567.1, Z98856.1, AC018441.3, AC027476.2, AC027123.3, AC009590.4, AC021314.3, AC008221.3, AC008347.1, ALl 63545.4, ALl 63541.5, AL022287.1

SEQ ID NO: 394

ZH037/T7

AL137392.1, NMJH6195.1, ALl 17496.1, U93121.1, AL132715.2, AF123535.1, AF025309.2, AF04911 1.1, AF074609.1, AF074608.1, AF074607.1, AF025308.1, AJ277139.1, M64795.1, X82669.1, NC .001 134.1, AC010582.6, U34732.1 , U56248.1, Z35775.1, L33863.1 , X77199.1 , AE003812.1, AE003781.1, AC005359.1, Z36753.1, AA206237.1, AA402625.1, AI640101.1, AA166435.1, AI449051.1, AW641069.I , AV229003.1, AW637360.1, AW636913.1, AW104978.1, AI873411.1, AI744621.1, C82336.1, AI493892.1, AI468801.1, AA944214.1 , AA814955.1, AA742281.1, AA477401.1, AA479561.1, AA437337.1, H61147.1, H18470.1, T90042.1, AL157389.3, AC031975.3, AC027641.1 , AC022008.2, AC016018.7, AC019190.2, AC010975.3, AC069156.1, AC068918.2, AC026074.4, AC022269.3, AL355997.1

SEQ ID NO: 395 ZH054 T3 AF161348.1, AC006568.7, AE000692.1 , AE003650.1, AE003415.1, AL078603.4, NC_001 137.2, AC006020.2,

AC005940.3, AC006924.3, AC006258.1, AF054502.1, AF051344.1, U18779.1, AD000092.1, AL031289.1, AL034426.4, AL021917.1, M69188.1, AI948670.I , AI478382.1, AWl 60598.1, AW658028.1, AW793862.1, AA421360.1 , AW326431.1, AA774426.1, AW165025.1, AI959670.1, AI496955.1 , AW777910.1, AW281091.1, AV224187.1, AI167050.1 , AA741 176.1, AA148784.1, T98755.1 , AL355978.1, AC024509.2, AC019070.2, AC067740.2, AC055809.2, AC024705.4, AC063848.1, AC021360.3, AC021038.3, AC009965.4, AC017767.1, AC011049.3, AC026633.3, AC05351 1.2, AC020934.6, AC024190.2, AC027759.2, AC026561.2, AC023862.2, ACOl 1189.4, ACOl 1058.3, AC009792.4, AC020642.3, AC024480.2, ACOl 1566.3, AC025598.1, AC021535.2, AC023917.2, AC023847.2, AC013374.4, AC022888.2, AC012106.2, AC009483.2, AF178220.1 , AL121936.9, AL354812.5, AL161720.3, AL133338.3, AL356122.1 , AL355983.1, AL157413.6, AL355379.1, AL354914.1, AL031669.27, AL353614.1, AL157775.3, AL139353.1

SEQ ID NO: 396

ZH054 T7

AF039690.1, U79271.1, ALl 17525.1, AF136378.1, AL031650.21 , AC006919.5, AC006607.1, AE003496.1, NM_012776.1, AC008056.6, NM_001619.2, AC007538.5, S81843.1, S48813.1, U08438.1 , Z22173.1, Z68282.1,

ALl 21757.7, AL049544.4, AL031681.13, U39674.1 , L23127.1 , M34073.1 , M80776.1 , X61157.1 , M74822.1 , M87854.1 , X53421.1 , AI735499.1, AW028371.1, AI445418.1, AI266387.1 , AI288955.1, AW193663.1, AI298467.1, AI168222.1, AI148323.1 , AI140814.1, AI089322.1, AA879456.1, AA843811.1, AA829894.1, AA102109.1, AA029201.1, W72147.1, N51485.1, AI808317.1, AI033069.1 , AA161465.1, AA812519.1, N64528.1, H99906.1, AA886109.1, R71679.1, AI970343.1, AA744290.1, AW021346.1, AA099913.1, AW195719.1, AI267979.1, AA083859.1, AI038590.1, N51277.1, AA883684.1 , R07471.1, H98684.1 , R36854.1 , R39448.1 , F25334.1 , AA083954.1 , R54092.1 , H09074.1 , AA346369.1 , AA910762.1, N21975.1, D59844.1, AW195087.1, HI 1525.1, AA971254.1, W77907.1, AW057648.1, AL041060.1, AI659852.1, AA878973.1, AW392482.1 , AI057361.1, AA715235.1, F35739.1, W29097.1, AW022199.1 , AA860455.1 , AI963422.1, AA026096.1, AW427844.1, AI481147.1, T26899.1, AW413553.1, AW046739.1, AI529534.1, AI661769.1, AA269966.1, N71178.1, AI614472.1, AI713205.1, AI575014.1, AI112396.1, AI073194.1, AA026516.1, AI651890.1, AI575171.1, AA466212.1, AV162955.1 , AW495689.1, AI397450.1, AW547034.1, AW502609.1, AW479264.1, AI685864.1, AI652378.1, AA985290.1, AA161236.1, AC022960.2, AP001333.1, AC018648.2, AC068004.1, AC013699.2, AC021912.3, AC018685.5, AC016418.4, AF202962.1, AL139349.15, AL132661.15, ALl 17190.2, AC036143.2, AC010798.6, AC026746.3, AC016645.3, AC034117.2, AC018640.1, AC009244.20, AC068501.1, AC009444.2, AC026950.2, AC021551.4, AC021417.3, AC026750.2, AC020854.2, AC019240.4, AC025291.5, AC009577.3, AC026809.1, AC022882.3, AC016884.4, AC016721.4, AC016695.4, AC023002.1, AC024342.2, AC022828.2, AC012768.1, AC015865.1, ACOl 1290.2, AL157902.2, AL353720.2, AL355481.1, AL158068.4, AL162632.1, AL159973.2, AL133501.1, AL137007.4, AP001932.1, AP001586.1, AP001203.1 , AP001023.1, AP000425.1

SEQ ID NO: 397

ZH115/T3

U00951.1, NM_011767.1 , AF071059.1, U00960.1, NM_016107.1 , AFl 00742.1, AL020996.5, AC004226.1, AL020990.1,

AJ131040.1, M74208.1, AC006418.3, U88173.1, AL096773.6, AC009046.4, AF007276.1, AF235093.1, AE003528.1, AC004458.1, AC005234.1, AC002301.1 , AC005158.2, AF109780.1, AC005394.I , AC005355.I , AF001905.1,

AC004386.1, AC002418.1, AL163211.2, AL109762.3, Z77134.1, AL035427.17, AL023775.1, Z83843.1, ALl 10503.1, AP001666.1, AB004829.1, Zl 1876.1, AP001344.1, Z12134.1, AK000899.1, AP000494.1 , M94863.1, X53926.1, AI459274.1, AA884767.1, AW104349.1, AA233365.1, N92665.1, AI870590.1 , AI568546.1, N58504.1, AA601060.1, AA282826.1, AL120871.1, AA807029.1, AA232979.1, AI198040.1, AW407987.1, AL162096.1, AW803006.1, AW439732.1, AA807087.1, AA969488.1, AA121004.1, N99611.1, AA649579.1, AA344680.1, AA558006.1, W26569.1 , AW753743.1, AW281 1 17.1, AW762096.1, AW858925.1, AW625753.1, AW624533.1, AW455258.1, AJ280548.1 , AW219596.1, AW091636.1, AW018668.1, AI782083.1, AI774604.1, AA670786.1, AA004472.1, D67255.1, AW663818.1, AW625553.I , AW564331.1, AW388055.1, AV347281.1, AI791561.1, AI727561.1, AA903175.1, AA812908.1, AA810192.1, AA80681 1.1, AA477517.1, AA430246.1, AA191601.1, W32817.1, N44994.1, N27997.1, H44157.1, H42666.1, H26899.1, H26712.1 , H20671.1, H19589.1 , H10454.1, R79673.1, R65622.1, R34200.1, T94610.1, T85643.1, AC008949.5, AC016183.1, AC013605.1, AC048373.2, AC023060.3, AC010310.3, AC010607.4, AC009541.14, AC053536.2, AC025410.2, AL159170.3, AL109855.12, AC015536.3, AC025281.2, AC009683.3, AC019355.3, AC015793.2, AC016361.1, AP001404.1, AC012486.3, AC041020.2, AC058823.2, AC032018.2, AC068656.1 , AC025767.3, AC012615.3, ACOl 1405.4, AC044791.3, AC025763.2, AC024085.2, AC018664.7, AC018641.1, AC010533.3, AC010528.4, AC016284.4, AC023334.3, AC026611.2, AC026592.2, AC026565.2, AC026955.2, AC021836.3, AC022980.2, AC010960.3, ACOl 1901.2, AC023590.2, AC010066.5, AC013265.4, AC012448.3, AC016978.2, AC021826.1, AC014423.1, AC013742.1, AC011296.1, AC006594.1, AL355853.2, AL138891.5, AL354655.3, AL161421.3, AL136104.3, AP001861.1 SEQ ID NO: 398 ZH115/T7

NM_016107.1 , AF100742.1, AL137258.1, AE003787.1, AE003517.1, AE003467.1, AE002994.1, AC012328.4, AL163239.2, U56966.1 , AP000140.1, AP000228.1, AP000088.1 , AC008277.3, AE003688.1, AC005365.1, AF064866.1, AC004052.1, AL160413.6, AL161581.2, AL080317.11, Z84468.1, AL031589.10, AB040937.1, AL034567.1, AP000962.2, AW003071.1, AI697949.1, AA044907.1, AI459130.1, AI457645.1, AW043719.1, AI653343.1, AI215588.1, AI823552.1, AW169303.1, AI239441.1, AI355964.1, AI032008.1, AW193966.1, AI494082.1, AA977494.1, AA833810.1, AA452846.1 , AI922576.1, AI678750.1, AI522326.1, AI129323.1, AW009898.1, AI417741.1, AW512987.1, AA960990.1, AA459953.1, AW513344.1, AA133606.1, AA452986.1, AA133980.1, AW009457.1, AA126775.1, AA928638.1, AA922732.1, AA1826U .1, AA767799.1, N23288.1, R85777.1, AW292228.1, AI554259.1 , AA652535.1 , AI192659.1, AI590928.1, AA065256.1. H61311.1 , AW439475.1, AI219694.1, AI500438.1, AI431251.1, AI378745.1, H21148.1 , D20112.1,

AI270743.1, H85185.1, T57220.1, AA506082.1, AI880772.1, AW194028.1, AA181633.1 , Z19460.1, H88299.1 , T55419.1, R34592.1, AW518550.1 , AA046500.1, AW816525.1, T30297.1, AA450197.1 , AW143843.1, AA045458.1, AW104897.1, AA838848.1, AA163538.1, AA163136.1, AI230546.1, R69726.1, AA435277.1, AA825536.1, AA185159.1, AI235292.1, AI228295.1, AI702737.1, AI171031.1 , AA447301.1, AA963808.1, AW107691.1, N56482.1 , AW822973.1, AW555757.1, AI630711.1, AU019152.1, AA546061.1, ALl 18289.1, AA388699.1, AV327645.1 , AV210720.1, AVI 11836.1, AV331842.1, AV366554.1, AC008949.5, ACOl 1655.4, AC024292.2, AL133406.4, AC032019.2, AC014667.1, AC018657.8, ACOl 1029.3, ACOl 1266.3, AC006169.5, AC009378.5, AC017833.1, AC017293.1 , AC015864.1, AC015087.1, AP001162.1 , AC068645.2, AC009719.2, AC055730.1, AC018451.6, AC068474.1, AC024063.1, AC010899.3, AC012265.1, AL109912.5, AL162733.2

SEQ ID NO: 399

ZH1254/T3

AP000354.1, AC000095.3, X91348.1, AB002374.1, AC007744.2, AC005579.1, AC005265.1 , Z83839.1, U16027.1,

NC 001 136.2, AE003756.1, AC012188.2, NM_012504.1, AFl 15393.1, AF124366.1, AF124365.1, AC004527.2, AC004050.1, U97009.1, AC004638.1 , AL163204.2, AF022980.1, AL157475.1, AL031670.6, AL032643.1 , APOO 1634.1, Z68194.1 , X05882.1, D10359.1, U20499.1, L34160.1, M28647.1, M14511.1, Z99120.1, AL041214.1, AI479306.1, T19286.1, AV077676.1 , AW610362.1, AA469910.1, AW851333.1, AW851196.1, AW761950.1, AW475612.1, AW258171.1, AW23043I .1, AW161704.1, AW006996.1, AW006763.1, AI952960.1, AI786648.1 , AI608836.1 , AI583717.1 , AI378941.1, AI227130.1, AI225655.1, AI197153.1, AI157833.1, AH 19403.1, AI077445.1, AI034178.1, AA973649.1 , AA919330.1 , C83508.1 , C82652.1 , AA882029.1 , AA871165.1 , AA727880.1 , AA626956.1 , AA626943.1 ,

Z99358.1, AA563109.1, AA510094.1 , AA500957.1, AA494301.1, AA462637.1, AA462634.1, AA446699.1, AA446572.1, AA433925.1, AA286171.1, AA268339.1, AA238626.1, AA237522.1, AA208467.1, AA105429.1, AA105246.1 , AA105755.1, AA058303.1, AA014372.1, AA014032.1, W80249.1 , W54133.1 , W12919.1, N54195.I , N34293.1, R9581 1.1 , H34521.1, T96924.1, ACOl 1896.3, AC068808.4, AC010232.4, AF252831.1, AF252830.1 , AC034154.1, AC021680.3, AC023929.2, AL157375.1, AC069072.1, AC063926.2, ACOl 1830.3, AC026399.3, AC010480.4, AC020581.6, AC009329.18, AC012645.4, AC027414.2, AC067837.1, ACOl 1819.2, AC044802.1 , AC026881.3, AF235100.1 , AC021802.3, AC027352.1, AC026397.2, AC015991.3, AC026086.2, AC024154.1, AC016724.4, AC020616.3, AC022206.2, AC025266.1, AC018502.4, AC018499.2, AC011 143.3, AC024260.1, AC008214.3, AC013296.4, AC012994.1, ACOl 1832.2, AL139331.4, AL355995.1, AL355800.2, AL353581.3, AL138816.5, AL138916.5, AL161419.5, AL162502.2, AL118558.1, AL022594.18, AP001919.1, AP001593.1, APOO 1487.1 , AP000872.2, APOOl 133.1, Z92862.1

SEQ ID NO: 400 ZH1263 T3

AK000867.1, AC005632.2, AC009313.4, AC006761.1 , NC_001135.1, AF063023.1, AF003135.1, U41279.1, AL023655.1, X78964.1 , X59720.1, AC004077.2, AE003593.1 , Z83232.1 , Z81042.1, Z95126.1, AL109799.6, AL049658.1, M27965.1, NC_001136.2, AC008169.2, AC009303.2, AE003538.1, AC004846.2, AC004000.1, NM_001273.1, AC004936.2, AC006016.2, AC004513.1 , L63545.1, AC006064.9, AC004044.1, U96409.1, AC005859.1, AF069442.1 , AC002406.1, AL138640.1, AL161495.2, Z75542.1 , Z84468.1, ALl 10295.2, L78810.1, Z97195.1, L34213.1, M87378.1, X91498.1,

Z74106.1, Z74105.1, X54378.1, AB002314.2, AB024032.1, X93497.1, X86691.1, M97259.1, AA139239.1, AW320448.1, AA066190.1, AA133526.1 , AW205376.1, AW541589.1 , AA574532.1, AV155978.1 , AW837822.1, AW188258.1, AA963562.1 , AW594341.1, AA088126.1 , AI876844.1 , AI529340.1 , AAl 57075.1 , AI027222.1 , AW779632.1 , AI82091 1.1, AA293753.1, AV199216.1 , AV185506.1, AV185316.1, AV185007.1, AV184384.1, AV176628.1, C60137.1, C54010.1, C52297.1, C52274.1, C38524.1, C30959.1, C30741.1, C30240.1, Cl 1568.1, D65188.1 , D71090.1, AI998612.1,

AI903395.1, AI163787.1, T46763.1, T14163.1 , AA040957.1, AA389793.1 , U74171.1, N37898.1, R89930.1, T43416.1 , AV416695.1, AW743519.1 , AW503576.1, AW479966.1, AW261224.1, AW256152.1, AU079141.1, AW065755.1, AW047625.1, AW040516.1, AW037723.1, AW036849.1, AW036815.1, AW017630.1, AI929739.1, AI892446.1, AI841037.1, AI837262.1 , AI837252.1, AI833887.1, AI820275.1, AI820169.1 , AI812205.1, AV141733.1, AI739826.1, AI677235.1, AI612484.1, AU051441.1, AI415767.1, AI325757.1, AI257328.1, AA871426.I , AA869042.1, AA638053.1, AA637947.1, AA51 1893.1, AA212648.1, AAl 14610.1, AA105703.1, Wl 1346.1, R64480.1, AC025918.3, AL133501.1, AP000912.1, AP000843.1, AP000832.1, AC027144.1, AC006751.1, AL161417.5, AL163544.3, AC046187.2, AC027696.2, AC016881.4, AC016092.3, AC012571.3, AC016389.2, AC009554.4, AC018672.2, AC021846.3, AC026465.1, AC023929.2, AC023483.2, AC010055.3, AC010017.3, AC019296.1 , AC014071.1, AL138960.3, AL354754.1, AL158825.6, Z92850.1, AC044831.2, AC020947.5, AC016620.5, AC008384.4, AC012320.4, AC060816.1, AC062232.1, AC022325.4, ACOl 1965.3, AC0571 12.1, AC055527.1, AC054947.1, AC044361.1, AC026585.2, AC023414.2, AC009609.5, AC036460.1, AC023387.2, AC029749.1, AC026890.1, AC019016.3, AC023451.2, AC018987.3, AC010881.3, AC013500.3, AC012259.2, AC009615.2, AC006342.1 SEQ ID NO: 401 ZH1263/T7

AK000867.1, NM_002967.1, L43631.1 , AC004132.1, U72355.1 , AC005544.1, AL022098.1, AL031431.8, AL031984.13, AC004895.2, AL049759.10, AE003529.1, AC006456.2, AC005102.1, AC008122.15, AC002483.1, AC006065.3, AF038386.1, AL133367.2, AL137143.8, AL031535.1, AP001506.1, APOOl 129.1, X64070.1 , D58421.1, AC007797.7, NC_001 134.1 , AC002072.1 , AC002086.1 , AC006478.2, AC006367.3, AC006062.4, AC006508.2, U96409.1 , AF069442.1 , AF056324.1, AL163246.2, AL161495.2, AL109914.16, AL031846.2, AL035588.21 , Z95126.1, AL035610.3, AP001537.1, AWl 88258.1, AA931237.1, AI270586.1, AAl 57075.1, AW469488.1, AA594603.1, AA963562.1 , AAl 33526.1, AA625619.1, AA133527.1 , AI314762.1, AW079646.1 , AH 95236.1, AW320448.1 , AWl 34927.1, AW837822.1, AW230808.1 , AW209954.1, AV257871.1, AV246783.1, C88318.1 , AV302278.1, AA957172.1, AI652768.1, AU016133.1, AV261874.1, AV300983.1, AA574002.1, AV295600.1, AV116212.1, AV278604.1, AV310109.1 , AV258698.1, AA530285.1, AV269467.1, AV254504.1, AV349390.1 , A V304466.1 , AI908215.1, AI191742.1, AW557698.1, AI958379.1, AI883214.1, AV298177.1 , AV289122.1, AV159567.1, AV316503.1, AW352431.1, AA499071.1, AW367834.1 , AWl 00004.1 , AI832172.1 , AI380306.1 , N54920.1 , AI908571.1 , AA958853.1 , AW625559.1 , AW400052.1 , AJ389008.1, AV372035.1, AI950051.1, AI780357.1, AI485208.1, AI440408.1, AW767522.1, AJ012903.1, AW178731.1, AV299211.1, AI981755.1, AI933364.1, AI788142.1, AI787833.1, AI747929.1, AI256435.1 , AI132607.1 , AI037390.1, AA984240.1, W56148.1, N48528.1, AC025918.3, AC016297.3, AC022740.2, AC055799.1, AC018800.4, AC015772.5, AC015771.4, AC009646.3, AC060757.2, AC022746.3, AC023320.2, AC021583.3, AC021999.2, AC020754.2, ACOl 1606.5, AL354853.1, AL353145.1 , AL157717.2, AL157392.3, AC069133.1, AC025154.4, AC021913.4, AC017103.3, AL157951.2, AC044856.2, AC025574.5, AC021039.3, AC016347.1, AC012670.2, AC022505.8, AC068881.1, AC032040.2, AC010223.3, AC010002.3, AC008555.3, AC026930.2, AC016826.5, AC026635.2, AC027815.1, AC027788.1, AC027282.1, AC027146.1 , AC021859.3, AC015989.3, AC020787.2, ACOl 1296.1, AC005504.3, AC005958.1, AL031727.30, AL136181.5, AL355500.2, AC003022.1, AL355537.1, AL132778.3

SEQ ID NO:402 ZH1264/T3

NM_004985.1, AL355740.1 , ALl 21850.1, L00044.1, M54968.1, X07918.1, AW163408.1, AC026758.6, AC025886.2, AC021910.3

SEQ ID NO: 403 ZH1351/T3

AF 129085.1 , NM_005861.1, AF039689.1 , AF 129086.1 , Z92544.1 , AF003630.1 , AF003629.1 , U85251.1 , U85040.1 , U85039.1, NM_006114.1, NM_006326.1, AC007406.1, M60319.2, AF050154.1, AF043251.1, AF043250.1, AC005296.1, AC005696.1, AL050075.1 , AL021391.2, AIOl 1716.1, L19655.1, Y18007.1, M73822.1 , M62862.1, NM_013379.1, NM_015456.1, AC007968.3, AE003655.1, AE003552.1, AE003445.1, NM_011258.1, NM_006081.1, AF154502.1, AF091504.1, AF030050.1, U07157.1, AF059678.1 , AC003663.I , AJ002220.1, U15037.1, AL050280.1 , AL031595.4, AL034379.8, Z98742.5, X06542.1, D173I 5.1, M88489.1 , U36441.1, X72711.1, AB002354.2, X75917.1 , J05475.1, X56659.1, L10425.1, U01222.1, D78638.1, AW229260.1, AA195861.1, AI930417.1, H46782.1, AW083927.1 , AA377856.1, AA838975.1 , AA682253.1, AW476302.1, ALl 17791.1, AA316581.1, AA241988.1, AA869620.1, AAl 12509.1, R36755.1, AW490920.1, AA161202.1, AI820702.1, W75327.1, R46425.1, R73232.1, AA686448.1, AA096590.1, R54647.1, AA207360.1, H22194.1, R54607.1, H35582.1, AA199622.1, AAl 12436.1, AI663176.1 , AI663138.1, C04860.1, AI664611.1, AA243029.1 , AA454484.1, AA097453.1, AI658124.1, AA081740.1, AA967978.1 , AA686534.1, AI120234.1, AW077710.1, AW499155.1, AW498183.1, AI947742.1, AI935186.1, AI712244.1, AI668229.1 , AI664974.1 , AW673173.1 , AW487428.1 , A W248939.1 , AW246826.1 , AW077512.1 , AI968595.1 , AI968566.1 , AI873247.1, AI671905.1 , AI636773.1, AI205482.1, AA848256.1, AA757274.1, AW500801.1, AW402890.1, AI941571.1, AV063733.1, AV031907.1, AA465375.1, AA282673.1, U60304.1, W36532.1, H30685.1, AC068332.1, AC016209.3, ACOl 1847.3, ACOl 1556.5, ACOl 1531.6, ACOl 1481.2, AC009433.2, AC012122.2, AC021988.3, AC022408.3, AC021753.3, AC016741.2, AC022155.1, AC0121 16.1, AC067964.4, AC024523.2, AC027339.2, AC026730.3, AC027731.2, AC024736.3, AC027061.2, AC021 125.2, AC019312.3, AC025075.2, AC010121.6, AC009905.10, AC020120.1, AC010913.3, AC021584.1, AC013934.1, AC012990.1, AL355880.2, AP001578.1

SEQ ID NO:404

ZH1351/T7

AF129085.1, NM_005861.1, AF039689.1, Z92544.1, AF129086.1, Z46940.1, NM_015185.1, AE003761.1, AB007884.1, AC016951.9, M93129.1, AL021899.1, NM_004608.1, AF038163.I , AL137480.1, AB023231.1, U53344.1, AJ007989.1, M73980.1, Z63970.1, Z58600.1, Z64961.1, Z57538.1, AI630895.1, AI971879.1, AW074238.1, AA573790.1, AI097431.1, AI732281.1, AA775749.1 , AI133167.1, AI476536.1, AW272212.1, AI313142.1, AW074246.1, AA523100.1, AI922522.1, AA977131.1, AI567504.1, AI800972.1, AW519276.1, AW007382.1, AI265896.1, AA707243.1, AI186162.1, AA156751.1, AA872941.1, AA988951.1, AW780114.1, AA196335.1, AA777058.1, AI040100.1 , AI095230.1 , AI193384.1, AI884857.1, AI147782.1, AI084116.1, AI186356.1, AA156923.1, AI263601.1, AA916340.1, AA126861.1, AAl 14904.1, AAl 13285.1, AI367545.1, AI248132.1, AI350140.1, AI265894.1, AAl 13175.1 , AW392245.1 , AW134969.1, AI241250.1, AI829488.1, AW769510.1, AW800139.1 , AL045313.1, AA604290.1, H46715.1, R4401 1.1, T35752.1 , AA975174.1, AI801581.1, AA913651.1, AA100870.1, N44930.1, AW410549.1, AA358373.1, AI857353.1, F37468.1, N48716.1, AA114903.1, AA081740.1, T31912.1, AA127292.1, W19324.1 , AI954554.1, AW602696.1, AA431375.1, F36498.1 , H46168.1, AI250171.1, AI799945.1, F31326.1, AI270045.1, R73332.1, AI971264.1, R40538.1, AA034510.1, AI670750.1 ,

AA369419.1, R54831.1, N45564.1, T03682.1, R46339.1, AA161201.1, AI310818.1, R54844.1, AA551976.1, AA243030.1, T35464.1, AW632105.1, AW632304.1, R47890.1, AC068332.1, AC016209.3, AC007818.6, AC023027.1, AC012366.3, AC013071.1, AL355142.1, ACOl 1088.8, AC022266.3, AC020772.3, AC021830.5, AC018775.3, AC016796.2, AC024694.1, AC021051.2, AP000795.1, AC007849.6, AC048387.2, AC012645.4, AC039056.3, AC068518.1, AC027522.2, AC021443.5, AC034149.2, AC020736.2, AC025893.2, AC026088.1, AC025540.2, AC020963.1, AC023104.2, AC022328.4, AC009877.2, AL354697.4, AL353604.2, AL160397.4, AL159156.4, AL158196.4, AL139331.4, AL137248.7, AL354817.3, AL157697.4, AL161793.3, AL158092.4

SEQ ID NO:405 ZH1353/T3

NM_014497.1, D83032.1, NM_008717.1, D83033.1, AP000064.1 , NM_015825.1 , AE003511.1, AC003077.1, AC010205.5, AF060568.1, AC005409.1, AC001234.1, ALl 10505.3, ALl 10485.1, Z50806.1, Z92793.1, Z81453.1, AJ239082.1, NM_001379.1, NC_001144.1 , AC025436.2, AC007184.3, AC004683.2, AE003729.1, AE003505.1, AE003436.1, AF180682.1, AC004981.1, AC0081 15.3, AC007091.3, ACO05837.1, AL163241.2, AL163223.2, AL133316.2, AL132716.4, Z68338.1, Z68010.1, Z83218.1 , Z72520.2, AL023755.5, Z99758.7, AL035608.i l, AL031 178.1, AL049765.16, AP001678.1, AP001696.1, AP001597.1, AP001256.2, X63692.1, Z73113.1, X91488.1, L00683.1, AL047923.1, AL047919.1 , AW083145.1, AA193367.1, AW439085.1, AI865323.1 , AW665552.1, AA563264.1, AW373007.1, AA193368.1, AU041796.1, AW852954.1, AU041432.1 , AA914225.1, AA645822.1, AA167998.1, AA167934.1, W29289.1, AW743893.1 , AW728503.1, AW505299.1, AW504938.1, AW503793.1, AW500273.1, AW376905.1, AI890946.1, AI426374.1, AI034353.1, AA714325.1, AA703165.1, W69840.1, H60273.1, R49310.1,

T05051.1, AC064868.1, AC012119.2, AC020682.2, AC012574.2, AC024105.7, AC025995.1, ACOl 1 172.4, AF217246.2, AC061958.4, AC027256.2, ACOl 1789.4, AC018362.3, AC015342.1, AL162573.5, AL354705.1, AL163534.3, Z92852.20, Z98854.1, AP000774.1, AP000772.1, Z96103.1, AC021173.3, AC026904.2, AC007960.14, AC008688.6, AC010223.3, ACOl 1345.3, AC027115.2, AC009855.2, AC012050.1, AL356134.2, AL137075.1 1, AL158011.1 , AP001485.1

SEQ ID NO:406 ZH1353/T7

NM_014497.1, D83032.1, NM_014120.1, AF090903.1, NM_008717.1, D83033.1, AC004513.1 , Z54366.1, AL031307.1, AC002053.2, AF214116.1, AC010852.5, Z81072.1 , Y171 16.1, NC .001 145.1, AC003105.2, AE003787.1, AE003185.1, AF178680.1, AC006950.1, AC005960.1, AF106582.1, AF041439.1, AF019753.1, AF039232.1, AF000657.1, AL024495.1, Y07829.2, U64804.1, AP000518.1, AK000669.1, Z74846.1, Z74845.1, Z72797.1, Z72795.1, Z48952.1, AB023055.1, AB023054.1, Z81314.1, AB018505.1, D90353.1, X98506.1, AI357871.1, AW613119.1, AW129956.1, AA861081.1, AA088340.1, AI949210.1, AI082565.1, AA911979.1, A A594005.1, AL047924.1, AA232142.1, AW170795.1, AI217066.1, AI078839.1, AW193031.1, AI080190.1, AA421829.1, AA147532.1, AI242642.1, AI401436.1, AA825391.1, AI890636.1, AW029010.1, W95261.1, AI493374.1, AW264735.1, AI253533.1, AI808939.1, D79956.1, AW080968.1, AI270468.1, AI610884.1, AL041312.1, R74381.1, AW627822.1, AA136235.1, AA136289.1, AA659078.1, AA411994.1, AI492527.1, AW537086.1, D61038.1, AW558381.1, W95162.1, AL046548.1, AA484122.1, AW539466.1, D60905.1, AI868183.1, AI044040.1 , A W491800.1 , AI235272.1 , AI511149.1 , AW521139.1, AA510275.1 , AW609062.1 , AW581790.1 , AI074733.1, AI481212.1, AA924121.1, C15661.1, AU019514.1, C86815.1, AI661220.1, AA792930.1, AA183214.1, AA414868.1, AA402457.1, AV287351.1, AV029240.1, AV234489.1 , AI608062.1 , AV348633.1, AV300581.1, AV 144934.1, AA286178.1, AV322924.1, AW673523.1, AV322832.1, AV232883.1, AA088339.1, AV315224.1, AA598824.1, AF017341.1, AI811965.1, AW487346.1, AA254078.1, AI223846.1, AI745175.1, AI264811.1, AW466507.1, AW300583.1, AW175521.1, AA930184.1, AI898982.1, AI487578.1, N71735.1, AC016485.2, AF238279.1, AC007898.2, AC021966.3, AC024100.8, AC026474.3, AC010177.3, AC012040.8, AC024022.3, AC021786.2, AC016844.3, AC012172.3, AC021291.3, AC012301.2, AL137881.10, AL354924.1, AC036163.2, AC048373.2, AC009452.9, ACOl 0348.3, AC039057.3, ALl 39407.2,

SEQ ID NO:407 ZH1396/T3

NC_001807.2, J01415.1, AF054990.1, X93334.1, V00710.1, V00662.1, X62996.1, D38112.1, D50525.1, X93335.1, NC_001643.1, D38113.1, X93347.1, NC_001644.1, D38116.1, NC_001645.1, D38114.1, NC_002082.1, X99256.1, NC_001646.1, D38115.1, AK000348.1, Y17174.1, NC_002083.1, X97707.I, Y17170.1, Y18621.1, NC_001992.1, Y18001.1, NM_004185.1, Z71621.1, X89846.1, X02226.1, M12298.1, AL163203.2, AL050302.2, AP000026.1, AP000025.1, U66061.I, AF029308.1, AF203727.1, U97340.1, AF203744.1, AF203743.1, AF203741.1, AF203740.1, AL049911.2, M86493.1, M86495.1, M35875.1, M86494.1, AB019564.1, NC_001808.1, NC_001567.1, J01394.1, NC_002080.1, X88898.1, Y07726.1, V00654.1, M86497.1, M86496.1, U97337.2, U97343.1, M33552.1, AFl 79288.1, AF203742.1, U97336.2, NC_001941.1, AF010406.1, AF069533.1, AJ010812.1, AB032843.1, M55539.1, M55541.1, M86500.1, M86501.1, AF069539.1, AF069537.1, NC .001640.1, AF027999.2, M55540.1, X79547.1, NC .001601.1, NC_002078.1, NC_002009.1, AF061340.1, AF069535.1, U97338.1, X72204.I, AJ010816.1, AJ010815.1, Y18475.1, U97335.1, NC_001913.1, AJ001588.1, NC_001821.1, Y11832.1, NC_000934.1, AF039436.1, AJ224821.1 AW854289.1, AW854282.1, AW854273.1, AW854272.1, AW853914.1, AW853911.1, AW837655.1, AW102881.1, AA856781.1, AA809120.1, AA809087.1, AA809068.1, AA808965.1, AA714382.1, AA578668.1, AA563919.1, AA563906.1 , AA555052.1 , AA554931.1, AA554581.1, AA554476.1 , AA553856.1 , AA548860.1 , AA548859.1 , AA548858.1, AA218984.1, AA069787.1, AA722510.1, AA613979.1, AA595777.1, AA595749.1, AA565897.1, AA565384.1, AA565326.1, AA564585.1, AA555049.1, AA554772.1, AA554579.1, AA548947.1, AA548856.1, AA548348.1 , AA548347.1 , AA548329.1 , AA548322.1 , AA548235.1 , AA485302.1 , AA 131338.1 , AA565377.1 , AAl 67502.1, AW605623.1, AA565784.1, AW854396.1, AW854392.1, AW854391.1, AW854384.1, AW854275.1', AW604467.1, AW604461.1, AW578557.1, AW578546.1, AWl 66949.1, AW027425.1, AI525852.1, AI281529.1, AA868519.1, AA593698.1, AA593692.1, AA575889.1, AA554597.1, AA553425.1, AA156195.1, C17533.1, AL047740.1, AA714377.1, AA576595.1, AA809137.1, AA595706.1, AW854407.1, AW854399.1, AW854398.1, AW854390.1, AW854388.1 , AW854386.1 , A W854385.1 , AW854067.1 , A W853921.1, AW837654.1 , AW837523.1 , AW795411.1 , AW604474.1, AW604473.1, AW601676.1, AW578558.1, AW577448.1, AA249295.1, AW854394.1, AW474560.1, AI086871.1, AA682021.1, AA469382.1 AC024033.2, AC021914.3, AC010270.4, AC067744.2, AC026931.2, AC068619.1, AC022223.11, AC068621.1, AC021616.4, AC016920.4, AC063928.2, AC067925.1, AC021473.3, AC015935.4, AC025337.1, AC023928.3, AL356032.1, AL355887.1, AF182108.1, AC058808.1, AC021835.3, AL161450.4, AL121927.18, AL121909.9, AL121898.13, AC025936.2, AC025380.2, AC021451.2, AL158819.2, AC018856.3, AC013437.3, AC013804.2, AC021802.3, AC026086.2, AC024498.2, AL162272.3, AC024351.2, ACOl 1029.3, AC012365.3, AL355516.2, AL157765.1, AL356135.1, AC013272.2, AC024248.3, AL109955.13, AL135939.9, AC009499.2, AC025283.1, AC051663.4, AC025731.7, AC018892.2, AC022264.2, AC020699.2, AC019138.2, AC017099.3, AL133466.15, AC012349.3, AC027530.2, AC025822.4, AC067768.1, AC019174.3, AC024512.2, AC016532.2, AC021982.1, AL138926.2, AL161738.4, AC004469.2, AC046186.2, AC018763.3, AC010438.5, AC025692.3, AC009240.3, AC016348.3, AC012568.3, AL136316.3, AL353707.1

SEQ ID NO:408

ZH1396 T7

ALl 10479.1, AW170035.1, AL157387.1, AC023885.3, AC023666.3, AC008717.3, Z98855.1 SEQ IDNO:409 ZH148/T3

AP000354.1, AC000095.3, X91348.1, AC007744.2, AC005265.1, Z83839.1, U16027.1, AC010163.7, AE003756.1, AC012188.2, NM_012504.1, AFl 15393.1, AF124366.1, AF124365.1, AC004527.2, AC006141.2, AC004050.1, U97009.1, AL163204.2, AL157475.1, AL031670.6, AL032643.1, AP001634.1, U39650.1, X05882.1, D10359.1, U20499.1, L34160.1, AP000525.1, M28647.1 , M14511.1, Z99120.1, T19286.1, AL041214.1 , AI479306.1, AV139933.1, AV077676.1 , AW610362.1, AA469910.1, T14945.1, AW851333.1, AW851196.1, AW761950.1, AW475612.1, AW258171.1, AW230431.1, AW161704.1, AW006996.1, AW006763.1, AI952960.1, AI786648.1, AI608836.1, AI583717.1 , AI378941.1, AI227130.1 , AI225655.1, AI197153.1, AI157833.1 , All 19403.1, AI034178.1, AA973649.1, AA919330.1, C83508.1 , C82652.1, AA882029.1 , AA871165.1 , AA727880.1, Z99358.1, AA563109.1, AA510094.1, AA500957.1, AA494301.1, AA462637.1, AA462634.1, AA446699.1, AA446572.1, AA433925.1, AA286171.1, AA268339.1, AA238626.1 , AA237522.1, AA208467.1, AA105429.1, AA105246.1, AA105755.1, AA058303.1 , AA014372.1, AA014032.1, W80249.1, W54133.1 , W12919.1, N54195.1, N34293.1 , R95811.1, H34521.1, T96924.1, ACOl 1896.3, AC068808.4, AC008576.4, AF252831.1 , AF252830.1, AL157375.1, AC069072.1, AC063926.2, ACOl 1830.3, AC020581.6, AC009329.18, AC012645.4, AC027414.2, AC067837.1, ACOl 1819.2, AC026881.3, AF235100.1, AC021802.3, AC012122.2, AC027352.1, AC015991.3, AC026086.2, AC024154.1, AC022529.3, AC016724.4, AC020616.3, AC016855.3, AC022206.2, AC023879.2, AC025266.1, AC018502.4, AC018499.2, ACOl 1143.3, AC024260.1 , AC008214.3, AC013296.4, AC008130.5, AC012994.1, AL136227.4, AL135903.2, AL355995.1, AL355800.2, AL138801.5, AL353581.3, AL138816.5, AL138916.5, AL161419.5, AL162502.2, AL138780.1, AL022594.18, AP001593.1, Z92862.1

SEQ ID NO:410

ZH148/T7

AP000354.1 , ACOl 1311.11, AC003070.1, AC002455.1 , ALl 33163.2, AL122021.3, AL096701.14, AL021939.1,

AB019534.1, AC012156.14, AC0061 11.2, AC000159.6, AC004079.1, AC003080.1, AC005250.1, AC005227.2, AC005326.1 , AC006155.2, AC009247.11, AC005520.2, AC004797.1, AF001549.1, AC002553.1 , AC004645.1,

AL078582.13, AL121653.2, AL022327.17, Z95113.2, AL022165.1, Z84481.1, AP000065.1, AP000402.2, AP000352.2, AC000094.3, AC067968.1, ACOl 1465.4, AC000353.27, AC004008.1, AC002377.1, AC000085.5, AC006285.1 1 , AC007032.2, AC006040.2, AC002302.1, AC007308.13, AC004815.2, AC006387.3, AC007565.1 , AC007114.7, AC006942.1, AC004526.1, AC005562.1, AC006071.1, AC005725.1, U29895.1, AC005837.1, AC000086.1 , AC005670.1 , AL163270.2, AL135978.2, AL096699.i l, AL022318.2, AL022328.21, AL021578.1, AL031577.I , AL008633.1, AL008726.1, AP001725.1, AP000694.1, AC004841.2, AC005305.1, AC007957.35, AC005251.1, AC021092.1, AC010077.1 , AC005902.7, AC005479.2, AC004791.1, AL049776.3, AL121652.2, Z97054.1 , AL033524.i l, AP000689.1, AP000183.1, AP000039.1 , AP000557.2, AP000556.2, AP000493.1, AP000107.1, Y12851.1, AB003151.1 , ACOl 1508.4, AC006125.1 , AC005578.1, AC004475.1, AL034429.1, AD000092.1, AL049653.7, Z82976.1, AL031282.1 AI950934.1 , AA700333.1 , AL037285.1, AI343233.1, AI252124.1, AW856132.1, AW833865.1, AW471332.1, AW264986.1, AW004625.1, AI953425.1, AI744949.1, AI287475.1, AA720582.1, AA6351 19.1, AA634227.1 , AA613186.1 , AA601237.1, AA366582.1, AA092836.1, R78877.1, AW501542.1, AW439329.1, AW243687.1, AI972613.1, AI923052.1, AI822128.1, AI680323.1, AI564301.1, AI056701.1, AI049701.1, AI002762.1, AA745035.1, AA703900.1, AA664365.1 , AA639006.1, AA588864.1, AA579675.1, AA069619.1 , W01978.1, N70179.1. N36147.1, N25272.1, R31185.1, F02692.1. T07769.1, AW846607.1, AW131315.1, AI799545.1, AI793343.1, AA618472.1, AA516313.1, AA515753.1, AA481779.1, AW816346.1, AW496802.1, AW468048.1, AW402688.1, AL134608.1, AW193609.1, AW130535.1, AW129694.1, AW085740.1, AL045870.2, AW001268.1, AI884487.1, AI810220.1, AI676218.1, AL048065.1, AI635475.1, AI620992.1 , AI611202.1, AI610607.1 , AI524371.1, AI524193.1 , AI510838.1, AI311647.1, AA846935.1, AA774127.1, AA737106.1, AA578847.1, AA558048.1, AA525206.1, AA448221.1, AA359041.1, AA219006.1, AA134959.1, AA007673.1, W38404.1, N72717.1, N71291.1, N69517.1 , N68472.1, H72530.1, H70076.1, R84302.1, R08815.1, T58114.1, AI056792.1, W52505.1, ACOl 1896.3, AC016638.4, AC067727.1, AC016562.3, AC009097.5, AC013291.4, AC016404.2, AC018814.3, AC021584.1, AC016426.1, AC013312.2, AC015813.1, AL139150.1, AC018711.3, AL354932.4, AL161647.5, AL138781.3, AL139141.4, AL355534.1, AL163051.1, AL138733.2, AC055747.1 , ACOl 3644.3, AC025552.3, AC024509.2, AC013489.3, AL355978.1, AP001261.1, AC015551.8, AC022130.3, AC020904.5, ACOl 1452.5, AC008945.3, AC020983.4, ACOl 8663.1 , AC023499.3, AC027812.2, AC068074.1 , AC009314.3, AC027057.2, AC026653.2, AC016700.2, AC016837.3, AC019095.2, ACOl 1216.3, AC024511.2, AC022594.3, AC024366.1, AC004555.2, AL139098.4, AL139410.2, AL033529.16, AL136293.2, AL139388.1, AC036208.2, AC036174.2, AC055781.2, AC068785.4, AC061970.2, AC032036.2, AC027324.2, AC012615.3, AC008828.3, AC008689.4, AC018636.1, AC016582.4, ACOl 1495.3, AC010319.6, AC025483.2, AC023771.4, AC021016.3, ACOl 1736.3, AC016496.3, AC023343.2, AC012185.3, AC021736.3, AC015878.4, AC008026.2, AC009427.2, AC024601.2, AC016730.4, AC000005.1, AC018391.4, AC006286.13, AC022460.2, AC010684.3, AC006342.1, AL354935.3, AL132868.12, AL158212.4, AL353701.1, AL160000.2, AL138842.2, AC023053.7, AC019205.3, AC012002.3, AL109804.26, AL158815.4, AC032035.2, AC026125.1

SEQ ID NO:41 1

ZH119 T3

AF126008.1, AF127481.1, NM_006738.1, U03634.1, NM_012026.1, U73199.1 , AC004815.2, AP000058.1, AC018452.10,

NM_004723.1, NM_002728.1, U72206.1, AL157431.1, AB014551.2, Z26248.1, AFl 13018.1, AC000365.1, NM_006074.1, AC006560.8, AFl 10972.1, AFl 10969.1, AF098098.1, AF098089.1, AF098081.1, AF038115.1 ,

AF014101.1 , AF056139.1, AF056137.1, AF056130.1, U65549.1, U65072.1, AC005622.1, AF053298.1, AF053281.1,

AF045631.1 , U47100.1 , U86769.1 , U56368.1 , U58797.1 , Z98044.13, AL049766.14, Z68870.1 , AL034417.14, U08455.1 ,

AP001437.1, AP000411.1, AP00001 1.2

AI080516.1, AA680040.1, AA160400.1, AV175589.1, Z18299.1, AW239879.1, AW368143.1 , AL138205.1, AA471378.1, AA190443.1, AW561862.1, AW561797.1, AW561792.1, AW561783.1, AW166107.1, AV323271.1, AW080955.1, AW026304.1, AW003886.1, AI997942.1, AI969095.1, AI944384.1, AI783154.1, AI751341.1, AI723669.1, AI723667.1, AU068139.1, AI570753.1, AI545330.1, AI500562.1, AI309847.1, AI234422.1, AI234414.1, AI133033.1, AI052895.1, AI052878.1, AA933127.1, AA835773.1, AA808246.1, AA742198.1, AA720586.1, AA491530.1, AA489204.1, AA406885.1, AA395608.1, AA228562.1, AA228561.1, AA228541.1, AA 142390.1, AA083407.1, AA083478.1,

AA051057.1, AA050677.1, W59866.1, W54301.1, W51561.1, W51638.1, W51531.1, N81361.1, N43467.1, H67519.1, H67518.1, AC068402.1, AC007897.2, AC021739.1, AC044822.1, AC026840.1, AC023885.3, AC055760.2, ACOl 1386.4, AC023190.2, AC015685.2, AC007430.17, AC023599.7, AC040906.2, AC008633.3, AC010862.5, AC008740.3, AC026521.2, AC026770.3, AC009994.4, AC026657.3, AC010727.3, AC040920.1, AC007601.2, AC021420.3, AC021814.2, AC021811.2, AC022195.2, AC024732.2, AC024329.2, AC013282.3, AC015762.2, AC016747.3, AL353194.5, AP001895.1, AP000869.1

SEQ ID NO:412 ZH119/T7 NM_002439.1, U61981.1, J04810.1, D61418.1, D61419.1, D61416.1, D61417.1, M80360.1, L10317.1, L10316.1, L10318.1, AL163284.2, L10319.1, U41038.I, AL022316.2, AL121815.1, NC_001147.1, AF 132734.1. AC007211.5, M60855.2, AE003766.1, AE003677.1, AE003629.1, AF221096.1, U91324.1, AF156865.1, AF156864.1, AF156863.1, AF156862.1, AE001707.1, AF105197.1, AF105192.1, AF105191.1, AF105181.1, AF105173.1, AF105172.1, AF105171.1, AF105170.1, AF105163.1, AF105162.1, AF105161.1, AF105160.1, AF105158.1, AF105157.1, U55020.1, AC002553.1, AC002549.1, U67508.1, AF013754.1, AL121965.19, AL138996.2, K02212.1, AL132708.3, AC000123.1, AL035086.12, AL035258.10, X55746.1, X55752.1, Z75058.1, AB015472.1, AW069265.1, AI888396.1, AI000562.1, AA969963.1, AA587200.1, AW321566.1, AI495086.1, AV427755.1, AV413150.1, AV411521.1, AI674413.1, AW795485.1, AW700074.1, AW576548.1, AW558153.1, AW320131.1, AW302482.1, AW273452.1, AW172797.1, AV331283.1, AV382870.1, AW041682.1, AI982667.1, AI953902.1, AI937839.1, AI820081.1, AI819300.1, AI814500.1, AI744664.1, AI742562.1, AV044143.2, AI658876.1, AI658322.1, AI657880.1, AI556716.1, AI537928.1, AI494668.1, AI358429.1, AU031621.1, AI176155.1, AI072955.1, AA948029.1, AA703667.1, AA686049.1, AA582962.1, AA558493.1, AA550767.1, AA542978.1 , AA534864.1 , AA533877.1, AA475323.1, AA349463.1, H07126.1, H06698.1, R49574.1, R16987.1, AC008557.5, AC016565.4, AC022493.7, AC021649.9, AC021065.3, AC010594.4, AC008824.4, AL121837.13, AJ011929.1, AC040890.1, AC024996.2, AC013803.3, AC013772.3, Z98869.1 , AC027648.6, AC060788.2, AC024108.5, AC058823.2, AC018764.4, AC010263.4, AC008771.3, AC022415.4, AC012618.3, ACOl 151 1.4, AC009617.4, AC021063.11, AC013361.4, AC064794.1, AC062036.1, AC023108.3, ACOl 1287.3, AC027217.2, AC044847.1, AC009924.4, AC025033.4, AC019351.3, AC016714.2, AC007223.1, AC016294.2, AC024314.1, AC008093.3, AC023714.2, AC009490.5, AC019072.1, AC007300.5, AC017445.1, AC018047.1, AC010936.2, AC014353.1, AL135790.2, AL356011.1, AL121714.29, AL355609.1, AL138816.5, AL355552.1, ALl 17259.2, AL157764.1

SEQ ID NO:413

ZH1331/T3

AB002374.1, AP000354.1, AC000095.3, X91348.1, AC004702.1, AJ009615.2, AL021367.1, AC007744.2, AC005265.1,

AF036702.1, AL138996.2, Z83839.1, U16027.1, AC010498.4, U78721.2, AE003817.1, AE003756.1, AC012188.2, NM_012504.1, NM_005426.1, AFl 15393.1, AF124366.1, AF124365.1, AF076337.1, AC004527.2, AC005977.3,

AC004050.1, U97009.1, U58334.1, AC004638.1, AC004587.1, AL163222.2, AL163204.2, AL161547.2, AL021889.2, ALl 57475.1, AL031670.6, AL032643.1, Z85999.1, AL035555.10, AB026898.1, AP001677.1, AP001634.1, U42462.1, AP000946.3, L13696.1, U39650.1, X05882.1, D10359.1, U20499.1, L34160.1, AP000500.1, M28647.I, M14511.1, Z99120.1, AW504383.1, AA564137.1, AL044805.1, T19286.1, AL041214.1, AV315094.1, AW483783.1, AI479306.1, AW732340.1, AW297086.1, AV077676.1, AW610362.1, AI793990.1, AA469910.1, T92706.1, AW851333.1,

AW851196.1, AW761950.1, AW475612.1, AW258171.1, AW230431.1, AW161704.1, AL121236.1, AW006996.1, AW006763.1 , AI952960.1 , AI917611.1 , AI786648.1 , AI608836.1 , AI583717.1 , AI378941.1, AI227130.1 , AI225655.1 , AI197153.1, AI157833.1, AI119403.1, AI034178.1, AA973649.1, AA919330.1, C83508.1, C82652.1, AA882029.1, AA871165.1, AA727880.1, Z99358.1, AA563109.1, AA510094.1, AA500957.1, AA494301.1, AA462637.1, AA462634.1, AA446699.1, AA446572.1, AA433925.1, AA336354.1, AA290953.1, AA286171.1, AA279957.1, AA268339.1, AA238626.1, AA237522.1, AA208467.1, AA105429.1, AA105246.1, AA105755.1, AA058303.1, AA014372.1, AA014032.1, W80249.1, W54133.1, W12919.1, N54195.1, N34293.1, R95811.1, H34521.1, T96924.1, Z45637.1, ACOl 1896.3, AC068808.4, ACOl 1318.7, AC012020.8, AC008576.4, AC022319.3, AC019297.4, AC012340.2, AC015922.1, AL354046.2, AC027332.2, AC026432.2, AC011400.4, AC010625.3, AC008467.4, AC068004.1, AC012053.2, AF252831.1, AC010719.3, AC016664.2, AC015455.2, ALI58848.2, AL157375.1, AC069072.1, AC063958.6, AC068736.1, AC009329.18, AC012645.4, AC027414.2, AC027478.2, AC007485.2, AC009643.3, ACOl 1819.2, AC021798.5, AC023437.2, AC034290.1, AC026881.3, AF235100.1, AC021802.3, AC027352.1, AC015991.3, AC026086.2, AC022402.2, AC023048.4, AC016855.3, AC023399.2, AC018499.2, AC018946.4, AC024260.1, AC022711.1, AC010989.3, AC020328.1, AC013502.1, AL355995.1, AL355800.2, AL138916.5, Z92862.1

SEQ ID NO:414 ZH1331 T7

NC_001807.2, J01415.1, X93334.1, V00710.1, V00662.1, X62996.1, D38112.1, AF054990.I, D50525.1, X93335.1, NC_001643.1, D38113.1, NC_00I644.1, D38116.1, X93347.1, NC_001645.1, D38114.1, Y17170.1, NC_002082.1, X99256.1, NM_004185.1, Z71621.1, NC_002083.1, X97707.1, NC_001646.1, D38115.1, AB019564.1, AB017708.1, Y17174.1, M12298.1, U66061.1, AK000348.1, Y18621.1, X02226.1, NC_001992.1, Y18001.1, AF029308.1, Z70759.1, U25123.1, AF179290.1, AF203741.1, AF203744.1, AF203743.1, AF069537.1, NC .002391.1, Y19192.1, NC_001779.1, X97336.1, U78342.1, AF069536.1, AJ010812.1, NC_002009.1, AF061340.I, AB033608.1, AB032843.1, NC .001913.1, U97343.1, AJ001588.1, AF069534.1, AF203737.1, AF203727.1, AF069539.1, Y17323.1, AF203742.1, M86497.1,

NC .000845.1, AF034253.1, NC .001808.1, Y07726.1, NC_001700.1, U20753.1, AF203740.1, AF069538.1, M86493.1, M86495.1, NC_000889.1, NC_002080.1, X88898.1, AJ010815.1, AJ010813.1, AJ010957.1, U97337.2, AF203773:1, M55539.1, AF179288.1, U97336.2, AJ010816.1, AJ010814.1, M86500.1, M86501.1, AF203738.1, AB032842.1, NC_001892.1, AJ001562.1, AJ010817.1, M55540.1, NC_002078.1, AF069535.1, U97338.1, Y18475.1, AL047740.1, Al 132911.1 , AW837660.1 , AL048631.2, Al 114672.1 , AW837523.1 , AW837524.1 , Al 132942.1 , AW854289.1 ,

AI065135.1, AW854384.1, AW853921.1, AW604474.1, AW854282.1, AW853911.1, AW854396.1, AW853914.1, AW604461.1, AW854390.1, AW854398.1, AW854407.1, AW854392.1, AW604467.1, AW862475.1, AW860484.1, AW854391.1, AW854386.1, AW854385.1, AW854277.1 , AW854067.1 , AW601879.1, AW854388.1, AW854273.1, AW604473.1, AW604460.1, AW854394.1, AW854399.1, AW749569.1, AW578557.1, AW860501.1, AW860487.1, AW601822.1, AW610382.1, AW862468.1, AW860495.1, AW601876.1, AW862467.1, AW860488.1, AW860482.1, AW835481.1, AW860489.1, AW860470.1, AW860493.1, AW860491.1, AW853994.1, AW601877.1, AW862476.1, AW860499.1, AW860498.1, AW860497.1, A W601827.1, AA156195.1, AW860486.1 , AW854070.1 , AH 10658.1, AW862464.1, AW860504.1, AW860506.1, AW860485.1, AW860473.1, AW749572.1, AA837501.1, AW854272.1, AW862472.1 , AW862471.1, AW862466.1 , AW860503.1 , A W835494.1 , AW578566.1 , AW860474.1 , AW862469.1 , AW835335.1, AW862474.1, AW835474.1, AW854275.1, AW835488.1, AW610324.1, AA211604.1, AW835492.1, AW835359.1, AW601869.1, AW835497.1, AI525852.1, AW578558.1, AW605188.1, AW578546.I, AA722510.1, AA593692.1, AA101199.1, AL036513.1, AC024033.2, AC010270.4, AC021914.3, AC022223.11, AC021616.4, AC026931.2, AC016920.4, AC068619.1, AC063928.2, AC013804.2, AC068621.1, AC067925.1, AC021473.3, AC018856.3, AC013437.3, AC024498.2, AC021835.3, AC012365.3, AC015935.4, AL161450.4, AL356032.1, AL355887.1, AC023928.3, AC025380.2, AL158819.2, AC058808.1, AC024248.3, AC025337.1, AL121927.18, AF182108.1, AC021451.2, AL121909.9, AL121898.13, AC051663.4, AC025731.7, AC025936.2, AL109955.13, AL135939.9, AC021802.3, AC026086.2, AC024351.2, ACOl 1029.3, AL355516.2, AL157765.1, AL356135.1, AC009499.2, AC025283.1, AC019138.2, AC013632.3, AC024250.4, AC009240.3, AL161738.4, AC008024.2, AL138926.2, AL133466.15, AL353147.3, AC013290.3, AC067768.1, AC019174.3, AC024512.2, AC016532.2, AC021982.1, AL355923.1, AP001571.1, AC069151.1, AC069141.1, AC004469.2, AC046186.2, AC024659.3, AC025692.3, AC021544.4, AC025388.2, AC022220.4, AC021860.3, AC023248.2, AC013480.3, AL157950.3, AL355032.1, AL109945.1, AL136454.3, AP001393.1

SEQ ID NO:415 DKFZp434B094

AF005067.1, AL080149.1, Z98885.1, AB033112.1, Z84485.1, NM_004634.1, AF176815.1, M91585.1, X64746.1, X64745.1, AE003841.1, AF203193.1, AF203192.1, AF203160.1, AF203138.1, AF203137.1, AF203118.1, AF129334.1, U37269.1 , U37268.1 , AF064681.1, AF064680.1 , AF064679.1 , AF064678.1 , U23487.1 , AK000751.1 , M58271.1 , M58270.1, M58269.1, M58268.1, M58267.1, M58266.1, M58265.1, M58264.1, M58263.1, M58262.1, M58261.1, M58260.1, M58259.1, M58258.1, M58257.1, M58256.1, M58255.1, M58254.1, M58251.1, M58212.1, M58207.1,

M58200.1, M58194.1, M58186.1, M58183.1, M58179.1, AF203182.1, AFl 10401.1, U27443.1, AF203140.1, AF203139.1, AF203I20.1, AF203119.1, NM_006751.1, AF174703.1, AF174702.1, AF174701.1, AF174698.1, AF174696.1, AF079325.1, AF120917.1, AF120916.1, AF120915.1, AF120914.1, AF120913.1, AF120912.1, AF120909.1, AF129381.1, U03340.1, U03338.1, AF082358.1, AL035703.20, M61199.1, AK001633.1, Zl 1812.1, AJ233022.1, AB014600.1, L15492.1, X07985.1, AL041903.1, AL040577.1, AW408719.1, AW176308.1, AW748208.1, H55108.1, AA340707.1, AV118538.1, AA930693.1, AW369905.1, HI 1686.1, M79139.1, D76571.1, HI 1889.1, AJ397954.1, AW674903.1, AF034196.1, AI907910.1, T98019.1, AA759003.1, AW752395.1, AW375924.1, AL047827.1, AI594388.1, AI551828.1, AI514970.1, AA990859.1, AA948792.1, AA615805.1, AA461239.1, AA428908.1, AA325161.1, AA187577.1, AA158452.1, AA076152.1, AA045603.1, W94477.1, W46356.1, W38747.1, N98297.1, H65630.1, H65071.1, R93581.1, R07789.1, T97395.1, T87592.1, AW737888.1, AW721225.1, AW598032.1, AW410598.1, AW398350.1, AW376978.1,

AW289794.1, AV391484.1, AW216360.1, AW047869.1, AI969973.1, AI948717.1, AI710520.1, AI705195.1, AI499756.1, AI454951.1, AI029325.1, AA859441.1, AI263045.1, AI175427.1, AI175396.1, AI170788.1, AI103955.1, AI076494.1, AI076474.1, AA843382.1, AA653055.1, AA467735.1, AA448354.1, AC063971.1, AC008034.13, AC066599.1, AC018829.3, ACOl 1610.5, AC021996.1, AC022382.1, AC008117.2, AL160033.6, AL162499.3, AC012738.1, AC009739.2, AC005425.3, AC021030.5, AC068893.1, AC021031.2, AC020909.4, AC021041.3, AC021033.2, AC022282.1, AC012285.1, AL079336.13, AL138703.2, AL353576.1, AC010789.8, AC048356.2, AC008737.6, AC024591.2, AC009108.6, AC023592.2, AC025929.2, AC015867.2, AC021769.3, AC020962.1, AC016774.2, AC010189.3, AC009962.3, AC020260.1, ACO 17435.1, AC007328.4, AL138809.13, AL133420.23, AL354919.4, AL139160.1

SEQ ID NO:416

DKFZp434p228

ALl 17590.1, AC007245.3, AC003683.1, AL355072.2, AC005120.1, AC006214.1, AL161550.2, AL021687.1,

AC007063.5, AC004535.1, AC013453.1, AF092369.1, AC004752.1, AL049777.5, AL096862.18, AL132764.1, AP000226.1, D85389.1, ACOl 1493.4, AC005662.2, AC002354.2, AE003163.1, AC021640.5, AC007536.9, AE001368.1, AF100956.1, AC004629.1, AL163232.2, AL031 177.1, AL031733.3, AL031653.5, AP001687.1, M77182.1 , M75889.1, AA175375.1, AI740728.1, AA332493.1, AW874606.1 , AI810796.1, AI087846.1, AI074062.1, AI016838.1 , AA470819.1, AI580915.1 , W85623.1, W85600.1, AI449083.1, AI549242.1, AI845400.1, AI383006.1, AV015395.1, AV375672.1 , AV32711 1.1, AI741614.1, AV354227.1, AV300969.1, AV376539.1, AV283831.1, AV253424.1, AW122375.1, AI604667.1 , AA771574.1 , A W332467.1 , AW642408.1 , AW636829.1 , AW635398.1 , AW634742.1 , AW634652.1 , AI467036.1, AA285835.1, AL135649.1, AV377755.1 , AI915385.1, AV173187.1, AV064014.1, AV062554.1, AI347646.1, AA808321.1, AA525659.1, AA458724.1, AA232022.1, AAl 18229.1, R12836.1, T37449.1, AC034212.3, AC022121.3, AC008522.4, AC008531.2, ACOl 1129.3, AC021824.2, AC023528.3, AC036206.2, AC020916.4, AC023808.3, AC025449.3, AC019274.3, AC015595.3, AC006280.6, AC022977.1 , ACO 13702.2, AL137780.2, AL135926.4, AC048385.2, AC032009.2, AC005077.2, AC027637.2, AC021515.3, AC013658.3, AC019328.4, AC021562.3, AL354805.2, AL139284.3, AL355811.2, AL035477.5, AL034557.7, AL031749.7,

SEQ ID NO:417 Ovarian Cancer downregulated myosin

NM_014890.1, U53445.1, AC004020.1, Z46792.1, AE003832.1, AC007557.3, AE001808.1, Z82203.1, X52075.1, M61827.1, AF104477.1, U60149.1, AF003530.1 , AC000403.1 , AL096867.15, Z82268.1, Z79758.1, AJ011002.1 , M32612.1, AF130358.2, AC004021.1, AC007560.3, AC005834.1, AL034419.19, AL133244.1, AL139076.2, AL021 171.1, Z82899.1, AL096769.7, U70850.1, U58751.1 , AW779584.1 , AW867011.1 , AW779587.1, C05084.1, AW779590.1, AI642381.1, AW751244.1 , AI606223.1, AW779641.1, AA611335.1, AA990984.1, AI940062.1, AV292155.1,

AA611336.1, AV343292.1, AV089962.1 , AI549138.1, AI554667.1, AI553756.1, AI402221.1, AI202123.1, AI084203.1, D75522.1, R54298.1 , AW309190.1, AV194167.1, AI614167.1, AI587990.1, AA964335.1 , AI068552.1, AA666699.1, C55082.1, AA497874.1, AA196522.1, AW871954.1 , AW208053.2, AW467155.1, AW459498.1, AW439057.1, AW401003.1, AW325166.1, AW322018.1, AV369587.1, AW168998.1, AV339384.1, AV259982.1, AV245839.1, AW104948.1, AW076711.1 , AI988870.1, AI854627.1, AI843433.1 , AI835147.1, AI765820.1, AI733300.1, AI733105.1 , AI536969.1 , AI494412.1, AA998598.1, AI429807.1, AI347598.1, AI228563.1, AI049016.1 , AA910905.1, AA629377.1, AA623952.1, AA537555.1 , AA387953.1, AA386853.1, AA274292.1, W97823.1, U31683.1, H09936.1 , T69472.1 , AC022883.3, AC024938.7, AC069222.1 , AC034172.2, AC007330.5, AC015178.1, AC010696.2, AL161632.4, AC025318.2, AL353632.4, AL353144.1,

SEQ ID NO:418

KIAA0103

NM_014673.1, D14659.1, AC004492.1, AC009233.3, Z99133.1, AC004838.2, AF048726.1 , AJ243213.1, AL033392.5,

AF146342.1, AC005875.2, AC007421.12, AF028834.1, Z99135.1 , AJ232463.1, AJ232461.1, AJ232460.1, AJ232459.1, AJ232458.1 , AJ232456.1, AJ232466.1, AJ232465.1, AJ232464.1, AJ232454.1, AJ232501.1, AJ232462.1 , L31948.1,

X68253.1, NC_001224.1, AE003578.1, AC00791 1.8, AC004802.1, AL110292.4, AL034556.3, AJ272279.2, AJ011856.1, AL034561.4, AL031427.15, NC_001137.2, AE003519.1, AF030694.2, AC004926.2, AC007402.3, AC005230.1, AC006199.1, AL137228.2, AL021395.15, Z72652.1, X87252.1, U07978.1, AL048716.3, AA447858.1, AI636359.1, AI669342.1 , AI669343.1, AI027953.1, AI566150.1, AW276600.1, AI339009.1, AA447703.1, AA88781 1.1, AI147898.1, AI679455.1 , AA836064.1, AA873375.1, AL038161.1, AA534251.1, AI422353.1, AA745251.1, AA708596.1, AWl 30877.1, AWl 68287.1, AW303995.1, AW204529.1, AI677854.1, AI420890.1 , AA935810.1, AA938493.1, AA687160.1, AI557375.1, AA311297.1, AA821444.1, T27967.1, AW583644.1, AA301507.1, AW583578.1, AA855729.1, AA935814.1, AA385797.1, AA560410.1, AA870575.1, N50202.1, AA301506.1 , AA683177.1, AA471359.1, C83495.1, C82639.1 , AA003181.1, AI525324.1 , AA545015.1 , AA 137986.1 , AA 163000.1 , AA 187086.1 , N68048.1 , AI555299.1 , AW009849.1, AW198055.1, AA638895.1 , AA530808.1, AA181333.1, AW592606.1, AI104356.1, AW209495.1 , AW644280.1, AA893851.1 , AI014068.1, AA067766.1, AI234816.1, AW765060.1, AI204083.1, AI156263.1, AW646028.1, AW123869.1, AW539200.1, AI102630.1 , AV171265.1 , AI556341.1, L26817.1, AA248265.1, AA797564.1 , AI843449.1, AW639641.1, AV250940.1, AI616839.1, AV260102.1, AV257129.1, AV253184.I, AV251229.1 , AV249657.1, AW124329.1 , AV172897.1, AV151001.1, AV127867.1, AVI 13481.1 , AV088039.1 , AV087721.1, AV060620.1, Z36450.1, AW764367.1 , AV040300.2, AC022634.3, AC019351.3, AC025826.1, AL138828.4, AC058784.2, AL355972.2, AL354717.1, AC068992.3, AC053499.2, AC018608.4, AC023075.2, AL353573.2, AL158149.3, AL138974.2, AL138683.2, AP002078.1, ACOl 1186.3, AC023492.2, AL138920.2, AP000878.1, AC0261 19.5, AC023757.4, ACOl 1257.3, AC016319.2, AC027073.2, AC025999.3, AC025380.2, AC023444.2, AC026224.1, AC016105.3, AC022812.2, AC024512.2, AC008182.1, AL161796.3, AL353789.1,

SEQ ID NO:419 Cosmid NFG9

AF126531.1, Z69719.1, NM_016310.1, AF051316.1, AE003791.1, AC067968.1, AC005034.1, AE002102.1, AL109943.18, Z98946.15, Z68887.1, Z50112.1, D88193.1, M97636.1, AE002705.1, AC018363.6, AC005018.2, U80837.1, AL021492.1, AB018007.1, AC002054.5, AC002049.4, AE003632.1, AC002045.1, AC002544.1, AC002395.1 , M94081.1, ALl 63279.2, Z98551.1, AE000662.1 , AL034556.3, AL031662.25, AL022326.1 , Z49237.1 , AL021713.1, AWl 67513.1 , AW138186.1 , AI760367.1, AI224102.1, AI094028.1, AI074736.1, AI369802.1, AI220149.1, AI313394.1, AI082184.1, AA263042.1, AI569242.1 , AA314434.1, AI241541.1, AA126951.1, AA912503.1, AI913788.1, AW275005.1, AA773182.1, AW418739.1 , AA827399.1, AA669773.1, AI268800.1, AA476966.1, AI868548.1, AW672863.1, AW385705.1, C00817.1 , AI368581.1, AA837254.1, AA352782.1, AW426495.1, AW381929.1, AW429636.1, AW426017.1, AA604039.1, AW785359.1, AW793665.1, AW675452.1, AA271604.1, W98752.1, AA009299.1, W59077.1, AI286727.1, AAl 18991.1, AI122511.1, W64539.1, AA822533.1, AA199237.1, AA051263.1, AA537627.1, AA590075.1, AA198139.1, AI858883.1, AW488481.1, AA268809.1, H31197.1, AW484117.1, AW484121.1, AA691124.1, AW003500.1, AW528612.1, AA120383.1, AI415794.1, AW637653.1, AU014893.1, AA606218.1, AW452227.1, AA413355.1, AW739254.1, AA736083.1, AA696686.1, AW346361.1, AU039136.1, C92913.1, C90605.1, C90570.1, AA148320.1, T67650.1, AW191223.1, AU076341.1, AV011661.1, AC010552.3, AC007604.1, AP001005.1, AC020707.2, AC018350.2, AC015996.2, AC016708.3, AC009218.6, AC016019.3, AC020202.1, AC007837.3, AC015972.3, AC016997.4, AC013404.1, AL355886.1, AL109769.2, AC010376.3, AC012316.4, AC019293.3, AC025335.2, AC023014.2, AC016226.1, AL158213.3, AC044809.2, AC040951.2, AC026709.2, AC025228.2, ACOl 1606.6, AC069127.1, AC051619.2, AC012645.4, AC021546.3, ACOl 1967.3, AC044828.1, AC026542.2, AC007718.2, AC019253.3, AC012107.2, AC026293.1, AC021145.3, AC021999.2, AC014357.1, AC015685.2, AC013812.2, AL356139.2, AL162731.2, AL136360.7, AL121922.7, SEQ ID NO:420

Zinc finger DNA binding Protein 89 kDa

AJ236885.1, L04282.1, AF039019.1, NM_011749.1, X98096.1, U30381.1, U80078.1, AJ001165.1, AE003846.1, AC007842.1, AF034212.1, AC005614.1, AC000385.1, AL133244.1, AL121656.2, AE003657.1, ACOl 1662.1, AC008125.9, AC007159.4, U63996.1, U69886.1, AL049648.6, AJ233997.1, AC007444.1, AC009312.3, AC008806.4, AE003754.1, AE003604.1, AE003583.1, NM_009445.1, NM_006526.1, AC009519.4, AF085244.I, AF085243.1, AC005552.1, AF083213.1, U32370.1, U30930.1, U09410.1, AF041259.1, AC004276.1, AF042090.1, AL163282.2, AL163224.2, Z83102.1, AL133070.1, AL031119.1, AP001679.1, AP001251.1, AB019227.1, M86377.1, AJ006687.1, AL038916.1, AW261045.1, AI158501.1, AA967471.1, AW425025.1, AI397213.1, AI385079.1, AW761766.1, AW740903.1, AV382076.1, AV379589.1, AV376903.1, AV370752.1, AV366011.1, AV364877.1, AV362453.1, AV352764.1, AV330621.1, AV294425.1, AV287896.1, AV268554.1, AV252401.1, AV252233.I, AV252222.1, AV218661.1, AV205194.1, AV157405.1, AV145061.1, AV139670.1, AV123571.1, AVI 16788.1, AV116109.1, AV114001.1, AV086136.1, AV085658.1, AV063815.1, AV014975.1, AV011220.1, AI450743.1, AI427142.1, AV305534.1, AV260003.1, AV167614.1, AV167001.1, AV165826.1, AV164748.1, AV123378.1, AVI 16499.1, AVI 12070.1, AVI 06069.1, AV102663.1, AV087776.1, AV087432.1 , AV040082.2, AI093969.1, AV440147.1, AW667700.1, AW637787.1, AW619431.1, AW619430.1, AW381210.1, AW359900.1, AW344493.1, AW004526.1,

AI853184.1, AI749512.1, AI380386.1, AA979011.1, AA911993.1, AA790790.1, AA784573.1, AA413750.1, AA197666.1, D86150.1, W27300.1, W05407.1, R19845.1, F08171.1, F06005.1, AC019289.3, AC032043.1, AC026618.1, AC013470.3, AC018137.1, AC010577.3, AL158034.2, AC068587.1, AC027238.2, AC020598.3, AC016812.4, AC019180.4, ACOl 1626.2, AC020648.4, AC009770.4, AC027193.2, AC040911.1, AC023143.3, AC015652.6, AC027362.1, AC026243.2, AC015653.3, ACOl 1936.4, AC023944.2, AC018208.1, AL139189.4, AL354939.3, AL354985.2,

SEQ ID NO: 421

ZH016/T3

AL080129.1, AK000323.1, X77864.1, AC006264.3, AE001806.1, AL035070.3, Y10300.1, AC002480.1, NM_002233.1, AC007388.3, AL021713.1, U41026.1, M60450.1, M55514.1, AB010700.1, L02751.1, AL021710.1, AE003592.1, AC007074.2, AL163236.2, AL109853.4, AP001691.1, AK001569.1, AI537278.1, AI962481.1, AW031973.1, AW031386.1, AA556462.1, ALl 35530.1, AI467338.1, AA438106.1, W05978.1, R58296.1, AV426794.1, AW771615.1, AW333984.1, AW234785.1, AV252087.1, AW056318.1, AW020852.1, AI997421.1, F35664.1, AI564380.1, AU050836.1, AI374842.1 , AI368114.1 , AI267738.1 , AI237631.1 , Al 109659.1 , AI030899.1 , AA894082.1 , AA892550.1 , AA850999.1 , AA800262.1, AA484703.1, AA283112.1, C18888.1, C18806.1, C18709.1, C18634.1, C18537.1, C18508.1, C18440.1, C18423.1, C18367.1, C17766.1, C17601.1, C17529.1, N74722.1, N52480.1, H02379.1, R33543.1, AC009497.2, AC019029.3, AC048380.2, AC024025.3, AC024288.2, AC007498.3, AC055880.2, AC021708.2, AL159989.3, AC027414.2, AC021172.3, AC013291.4, AC017355.1, AL137184.3, ALl 17259.2, AC064849.2, AC067830.1, AC026993.2, AC009427.2, AC024043.4, AC021252.3, AC023069.2, AC024056.2, AC016822.2, AC020166.1, ACO 10731.2, ALl 39118.4,

SEQ ID NO:422

ZH016/T7

AK000323.1, U79263.1, AC009363.4, AC007182.3, AC007504.3, AC007057.3, AL049872.3, AC006477.3, AC002073.1, AL034393.1, U15668.1, AB018573.1, AB025619.1, AC007458.13, AE003648.1, AL096712.20, AP000884.1, AI970820.1, AA831852.1, AA484320.1, AA226748.1, AI968567.1, AA363215.1, AA301296.1, R38172.1, AA371109.1, AI045735.1, AU016181.1, AI852657.1, AA684481.1, AA546723.1, AW549474.1, AA155568.1, AV313936.1, AV273922.1, AW359195.1, AU072042.1, AW727402.1, AV077600.1, AA866444.1, AW392740.1, AW279154.1, AW234824.1, AV089525.1, AI454887.1, AA441693.1, AA318189.1, N48302.1, AC019029.3, AC009497.2, AC066604.1, AC026182.2, AC022918.2, AC027489.2, AP001913.1, AP001565.1, AP001392.1, ACOl 1101.3, AL031113.1, AC069157.1, AC055808.2, AC025633.3, AC024699.2, AC016107.3, AC016471.4, AC005308.6, AL049183.5,

SEQ ID NO: 423 ZH032/T3 AC004985.2, AB040940.1, AC007882.3, ACOl 1456.2, AC002041.1, AC004583.1, AE003586.1, AC004439.1, AL049794.13, AW230312.1, AW861788.1, AW858314.1, AW861758.1, AW858265.1, AA050850.1, AI078919.1, F23291.1, AL353701.1, AL159997.3, AC022915.2, AC010539.3, AC025138.2, AC026495.1, AC024930.3, AC021 169.2, AC024283.2, AC007908.2, AL158155.2, AC027309.2, AC068518.1, AC020796.2, AC022858.3, AC016234.3, AC009989.6, AC022639.1, AC016276.2, AC017951.1, AC006514.6, AL133462.13, AL157700.2, AL133352.10, AL157858.1,

SEQ ID NO:424 ZH032/T7 AI675618.1, AL121389.1, AI953917.1, AI670867.1, AI420775.1, AI199226.1, AA570572.1, AA577683.1, AI801384.1, AA599079.1 , AI678864.1, AI673355.1, AI743710.1, AI973140.1, AI473720.1, AW168045.1, AI750437.1, AA918762.1, W78002.1, AI681468.1 , W26301.1, AW150595.1, AA515499.1, AW771215.1 , AI865546.1, AI701804.1, AW581686.1, AI0861 10.1 , W51793.1 , AI468490.1 , Z40982.1 , AA524294.1 , R48292.1 , AA235278.1 , AA401894.1 , AI951920.1 , AA411825.1 , W79461.1, AA773269.1, AW073072.1, AA234835.1, AA085172.1, D19722.1, AI942310.1, AA618179.1, W22327.1, AW488834.1, AI843985.1, AI051267.1, H91657.1, F04676.1, F04857.1, AW660383.1, AW660325.1,

AW590597.1 , AW489945.1, AW456044.1, AW137933.1, AI850275.1, AI844940.1, AI838491.1, AI703271.1, AI692281.1, AI680928.1, AI123752.1, AA996267.1, AA770038.1, AA703627.1, AA683172.1 , AA654126.1, D80530.1, D52575.1 , R48394.1, F04620.1, F02435.1 , W47361.1, AI176530.1 , AA800188.1, AI926298.1, AI923001.1, AI858244.1, AI681789.1, AI524221.1, AI313224.1, AI250876.1, AI244045.1, AH 98743.1 , AH 46789.1, AI128819.1, AA683568.1, AA633285.1, AA631580.1, AA225384.1, H18841.1, H15851.1, R46772.1, D20732.1, AW487979.1, AL354778.1, AL161644.2, AC008048.8, AC062010.2, AC018617.2, AC069147.2, AC009278.3, AC016884.4, AC010826.2, AL138827.3, AL157777.3, AP001023.1, AP000841.1, AP000813.1, AP000624.1, AC009133.5, AC023831.3, AC019152.4, AC009970.6, AC019151.2, AL121993.6, AL122010.2, AC063932.3, AC016526.3, AC016763.5, AC017080.4, AC018800.4, ACOl 1920.2, AL355539.1, AP001486.1, AP000875.1 , AC012600.4, AC012515.11, AC064800.2, AC068785.4, AC024677.3, AC010247.6, AC068443.1, AC027166.2, AC025238.3, AC013455.3, AC021934.3, AC012600.3, AC018758.1, AL354812.5, AL137855.2, AL133229.33, AL355492.2, AL353637.1, AP000812.1, AP000763.1, AC061705.3, AC010241.3, ACOl 1372.4, AC027542.2, ACOl 1927.3, ACOl 1646.3, AC027151.1, AC013614.4, AC019037.2, AL157776.4, AL138891.5, AL138752.3, AL138824.3, AL137073.2, AC022696.3, AC025356.1, AL139154.3, AL354834.2, AL158169.1, AP001121.1, AP000741.1, AC023491.13, AC007174.3, ACOl 1830.3, AC022165.3, AC026169.1, AC015478.3, AC022012.2, AC018502.4, AC019348.2, AC010732.3, AC018601.2, AL160270.3, AC044865.2, AC037461.1, AC027165.1, AC015894.2, AL136087.6, AC008630.3, AC012325.5, ACOl 1607.4, AC015469.2, AL139226.14, AL161640.6, AL353701.1, AL159997.3, AC022915.2, AC010539.3, AC025138.2, AC026495.1, AC024930.3, AC021169.2, AC024283.2, AC007908.2, AL158155.2, AC027309.2, AC068518.1 , AC020796.2, AC022858.3, AC016234.3, AC009989.6, AC022639.1, AC016276.2, AC017951.1 , AC006514.6, AL133462.13, AL157700.2, AL133352.10, AL157858.1,

SEQ ID NO:425

ZH036/T3

AF080158.1, AF031416.1, AF029684.1, AFl 15282.1, AF088910.1, AF026524.1, AC012446.2, AE003490.1 , Z 12841.1, AC011299.3, AC005288.1, AF064862.1, AF045449.1, AL163281.2, AI906358.1, AI906367.1, AA3261 15.1, AA128064.I , AA480228.1, AI913998.I , AA932082.1, W68756.1, AW299768.1, AW440835.1, AA622156.1, All 16314.1 , AI336571.1, AA670553.1 , AW107580.1, AW656805.1, AI207161.1, AU012191.1, AC023681.2, AC012902.1, AC034218.1, AL158191.3, AC012521.10, AC012600.4, AC036172.2, AC031982.2, AC067985.1, AC034197.2, AC044864.1, AC009789.2, AC026141.2, AC031064.1, AC026813.1 , AC018703.5, AC012600.3, AC022185.1, AL135901.4,

SEQ ID NO:426

ZH0610/T3

AB014592.1 , Z81477.1, AC002076.1, U95737.1 , NM_008515.1, AC004888.1, AC005913.1, AF045573.1, Z79605.1,

Z93372.1, AL034345.3, AL096825.2, D14521.1, Z29967.1, U10413.1, U1041 1.1, AC024757.1, AE003723.1, AE003558.1, AC003044.1 , AF 147262.1, AC006052.5, AL163235.2, AL163672.1, U07562.1, AL133417.10, AL161505.2, Z30662.1 , Z94160.1, AL031668.20, AL031778.1 , ALl 21770.1, X97907.1, AP001690.1, AP000476.2, Z86105.1, AI819413.1, AI924382.1, AI285875.1, AI763421.1, AI873246.1, AW269559.1, AW576160.1 , AW383436.1, AA292930.1, AI214572.1, AI283562.1, AA832360.1, AI924446.1, AW024483.1, AA872599.1, AA913675.1 , AW166702.1, R43429.1, AI277020.1, AI698939.1, AW504194.1, R45756.1 , AA293060.1, AW382696.1, AI201468.1, M78303.1 , AW382687.1, AL120220.1, AW825865.1, AW825841.1, AW050148.1, AW049090.1, AW532203.1, AW526348.1, AI710287.1 , AI704527.1, AI227931.1, AW825521.1, AI549397.1, AW690407.1, AW700877.1, AW252080.1, AV200996.1, D73302.1, AW137945.1 , AW006835.1, AI758397.1, AI249177.1, AH 44501.1, AA877636.1 , A A514763.1, N75450.1, AC055116.2, AC024259.7, AC025881.2, AC025389.2, AC023074.2, AC016494.3, Z99775.8, Z81452.1 , ACOl 1603.10, AC009172.4, ACOl 1474.2, AC027446.2, AC011197.3, AL138961.3, AL136316.3, AL353700.2, Z98857.36, AL021576.1 , Z92819.1, AC069065.1 , AC069198.1, AC036176.2, AC036129.2, AC015970.4, AC063973.5, AC009267.6, AC048379.2, AC064857.2, AC037469.2, AC012220.4, ACOl 1334.2, ACOl 1354.2, ACOl 1356.3, AC027526.2, AC067965.1, AC021165.3, AC007256.2, AC026960.2, AC015497.3, ACOl 1944.3, AC018403.4, AC027654.1, AC026390.1, AC022882.3, AC018935.4, AC021773.5, AC0191 1 1.3, AC009395.5, AC018826.3, AC022373.1, AC022846.2, AC023482.2, AC010042.4, AC022682.1, AC015977.3, AC018520.2, AC007812.5, AC018070.1, AC018100.1, AC016527.1, ACOl 1624.4, AC004580.2, AC006738.1, AC004579.1, AC004394.1, AL137244.14, AL162712.5, AL157785.2, AJ239319.3, AL353781.2,

SEQ ID NO:427 ZH0610/T7

AB014592.1, AF019413.1, L09706.1, AP000502.1, AC003970.1, AF016683.1 , AL162751.1, AB007650.1, X98806.1 , AE003797.1 , AC006019.2, AC004322.1 , AL122058.19, Z81036.1, Z98754.1, AL031668.20, L33769.1, AE003773.1, AE003655.1, AE003564.1, AC004691.1, AF178650.1 , AC005341.12, AF038609.2, AC006948.4, AF106564.1, AC003019.1, AC005723.1, AC005514.1, AC002366.1 , AC004004.1, AL163298.2, ALl 17186.3, AL132862.1, Z99171.1, Z68161.1, AL132979.2, Z68001.1, AL035634.7, AL031316.2, U41034.1, AP001753.1 , AB001523.1, AL120221.1,

AA929046.1, AI041 1 17.1 , AI827377.1, AW593254.1 , AA812962.1, AW024862.1, AA947740.1, AI246685.1, AI374810.1, AW276606.1, AI094081.1, AI348653.1, AI085257.1, AI381973.1, AI339534.1, AA447828.1, AI824989.1, N94582.1, H20695.1 , H20694.1, AW027408.1, AI913744.1, AA837844.1 , R50099.1, AW014667.1 , R59085.1, AW001701.1, AI493568.1 , H 18604.1 , H 18603.1 , H00470.1 , AA224209.1 , H00524.1 , R43106.1 , R64026.1 , H60970.1 , AA888554.1 , T89733.1, R76292.1, T89639.1, AA678432.1, D29431.1, AI796304.1, T89831.1 , AI581321.1, W85831.1 , AW505495.1, T89913.1, AA749373.1, AI866382.1, D20992.1 , AI907559.1, AW806478.1, AI993026.1, T44317.1, T42219.1, AA369223.1, AW825334.1, AW529924.1, AW410376.1, AW325591.1, AA528786.1, AA404694.1, H87801.1, T83925.1, AL139040.4, AC022548.2, AC015513.1, AC010204.9, AC069231.1, AC023566.3, AC024564.2, AC023254.3, AL135912.3, AC025759.2, AC008588.4, AC026994.2, AC015631.3, AC023770.2, AC009905.10, AC022695.3, AC022299.6, AC021096.3, ACOl 7056.3, AC006894.2, ALI57947.2, AL133274.7, AL022285.6,

SEQ ID NO:428

ZH067 T3

AC004985.2, AB040940.1, AK000661.1, Z98949.1, AL163288.2, AL022327.17, APOOl 743.1 , APOO 1504.1, AF230667.1, AE003714.1, AF177535.1, L48177.1 , AL163218.2, AL137665.1, AL022328.21, U80447.1, U31961.1 , AP000455.4, AP000382.1, M33971.1, M81411.1, AL121388.1, R47793.1, AW656364.1, C03870.1, W42331.1, AA270244.1, AV05389O.1, R48394.1, AW480347.1, AA524294.1, AW354814.1, W22327.1, AA982279.1, AA153449.1, W33419.1, AA085244.1, AW357644.1, AV096701.1 , AW049843.1, Rl 1437.1 , AW632605.1, AW464232.1, AW445542.1, AW431970.1, AW430227.1, AV239122.1, AW143188.1 , AA336769.1, AA336495.1, T40522.1,AC027803.1, AL121908.11, AC024913.16, AC024044.2, AC013366.6, AC017042.5, AC068770.3, AC026332.2, AC009801.3, AC068561.1, AC009105.6, ACOl 1124.3, AC026132.2, AC018953.5, AC027267.1, ACOl 1814.2, AC007940.2, AC024446.2, AC022563.1, AC012254.3, AC020430.1, AC016121.2, AC015515.2, AL163512.7, AL121780.3, AL137024.6, ,AL139132.4, SEQ ID NO:429 ZH067/T7

AC004985.2, AB040940.1, AK000661.1 , AL022314.1, AL008718.23, Z99943.1, NM_006695.1, AC002301.1, AF055026.1, AC003043.1 , U93871.1, AL021327.1, AC006322.2, AL049749.2, AL023879.1, Z83733.1, NM_014400.1, AC004843.1, AC008000.7, AF 120989.1 , AF082889.1, AF072246.1, AC005394.1, AC005173.1, Z99755.1, AL022153.1, AJ223603.2, AC004386.1, AC002418.1, AL009182.17, AL049565.3, Z83843.1, Z97205.1, AC008038.1, AD00I527.I , AF165142.1, AC007011.1, AC005831.1, AC004962.1, AF064860.1, AC002420.1 , AC002984.1 , AL163280.2, AL096714.1, AL137294.1, AL049814.6, Z70289.1, AL008583.1 , AL035455.29, Z22801.1 , Z22787.1, AK000120.1, AC007324.55, AC009288.13, AC007708.13, AC010491.3, ACOl 1506.3, AC000134.14, AC004812.1, AC006116.1, AF064858.1 , AC004775.1, AF041381.1 , AL163278.2, AL109827.8, AL121749.13, AL133500.2, Z83851.17, AL035659.22, AL049759.10, Z83844.5, AL023755.5, AL035086.12, Z97053.1, Y12508.1, AP000529.1, D86957.1, ACO08O33.8, AC003010.1, AC007191.1, AL031658.1 1 , AC007040.2, AC006312.8, AC006952.6, AC004687.1, AL138996.2, AL049636.21, AL121389.1, AI675618.1, AI953917.1, AI670867.1, AI420775.1, AI199226.1 , AA570572.1, AA577683.1, AI678864.1, AI801384.1, AA599079.1, AI673355.1, AI743710.1, AI473720.1, AW168045.1, AI973140.1, AI750437.1, AI681468.1, AA918762.1, W78002.1, W26301.1, AW150595.1, AA515499.1, AW771215.1 , AI701804.1, AI865546.1, AI086110.1, AW581686.1, W51793.1, Z40982.1, AI468490.1, AA234835.1, AA524294.1, R48292.1,

AA235278.1, AA401894.1 , AI951920.1, W79461.1, AA411825.1, AW073072.1, AA773269.1, AI942310.1, AA085172.1, D19722.1, AA618179.1, W22327.1, R48394.1, AW488834.1, AI843985.1, AI051267.1 , H91657.1 , F04676.1, F04857.1, AW785534.1 , A W731989.1, AW660383.1, AW660325.1 , AW590597.1, AW489945.1, AW456044.1, AW137933.1, AI850275.1, AI844940.1, AI838491.1, AI703271.1, AI692281.1, AI680928.1, AI352391.1, AI123752.1, AA996267.1 , AA770038.1, AA703627.1, AA683172.1, AA654126.1, AA482958.1, C21254.1, D80530.1, D52575.1, F10154.1, F04620.1 , F02435.1, Z40856.I , AA037243.1, W47361.1, AI176530.1, AA800188.1, AI926298.1, AI923001.1 , AI858244.1, AI681789.1, AI313224.1, AI244045.1, AI198743.1 , AI128819.1, AA631580.1, AA568435.1, AA225384.1, R46772.1, AW487979.1 , AL354778.1, AL161644.2, AC008048.8, AC062010.2, AC018617.2, AC069147.2, AC009278.3, AC016884.4, AC010826.2, AL138827.3, AL157777.3, AP001023.1, AP000841.1, AP000813.1, AP000624.1, AC009133.5, AC023831.3, AC019152.4, AC009970.6, AC019151.2, AL121993.6, AL122010.2, AC063932.3, AC016526.3, AC016763.5, AC017080.4, AC018800.4, ACOl 1920.2, AL355539.1, AP001486.1, AP000875.1, AC012600.4, AC012515.11 , AC064800.2, AC068785.4, AC024677.3, AC010247.6, AC068443.1, AC027166.2, AC025238.3, AC013455.3, AC013682.3, AC021934.3, AC012600.3, AC018758.1, AL354812.5, AL138847.3, AL137855.2, AL133229.33, AL355492.2, AL353637.1 , AP001590.1 , AP000763.1, AC061705.3, AC068683.1, AC010241.3, AC027542.2, ACOl 1927.3, ACOl 1646.3, AC027151.1, AC015855.4, AC013614.4, AC019037.2, AL157776.4, AL138752.3, AL138824.3, AP001007.1, AC022696.3, AC025356.1, AF121897.1 , AL356267.2, AL354834.2, AL160314.2, AL139244.2, AL158169.1, AP000741.1, AC023491.13, AC007174.3, ACOl 1830.3, AC008655.5, AC022165.3, AC018751.22, AC026169.1, AC022012.2, ACO18502.4, AC019348.2, AC010732.3, AC018601.2, AL160270.3, AJ239320.2, AC037461.1, AC015894.2, AL136087.6, AC008630.3, ACOl 1607.4, AC015469.2, AL139226.14, AL161640.6,

SEQ ID NO: 430 ZH1110/T3 NM_015642.1 , AL050276.1, AF194030.1, AF185576.1, AC008843.5, NM_001 166.1, U37547.1, L49431.1, ACOl 1738.4, NM_006585.1, AC006972.2, AC006384.2, AC004828.2, AC007052.4, AF077215.1, AC005144.1, AL163249.2, AL163243.2, AL109752.13, AL031283.26, AJ251713.1, AJ251712.1, AL035415.22, Z68332.1, AL035073.4, ALl 10503.1, D42052.1, AP001698.1, AP001601.1, D13627.1 , AA578163.1, AA069836.1, AW237166.1, H85064.1, AW502748.1, AW611145.1, AW106649.1, AI828036.1, AI221632.1, AA464297.1, AI151799.1, AW729812.1, AW372984.1, AW372983.1, AW235267.1, AI032501.1, AA702174.1, AA354613.1, AA281621.1 , AA034048.1, W80497.1 , W17275.1, T73134.1, AW731 100.1 , AW730874.1, AW730644.1, AW730370.1, AW728863.1, AW728739.1, AW728717.1, AW727809.1, AW673083.1, AW618417.1, AW247278.1, AW213355.1, AI648841.1 , AA984168.1, AA385412.1, AA347604.1, H88667.1, AC069063.1, AC026560.4, AC027493.2, AC055739.2, AC020896.4, AC063979.1, AC025358.3, AC036131.2, AC041009.1 , AC034154.1, AC027790.1, AC012056.3, AC024606.2, AC021712.3, AC022736.2, AL161444.2, AP001959.1, AC046138.4, AC022293.9, AC032022.2, AC068656.1 , AC025763.2, AC022894.2, AC025897.2, AC019309.3, AC021754.3, ACOl 1330.5, ACOl 1171.3, AC016135.1, AL136990.14, AP001830.1 , APOOl 167.1, AP000942.2, AC061973.2, AC064862.2, AC040957.2, AC025767.3, AC020930.4, AC008839.4, AC036127.2, AC037456.4, AC022218.4, AC019176.3, AC034167.2, AC026542.2, AC015992.3, AC021506.3, AC021005.2, AC025891.2, ACOl 1853.3, ACOl 1848.5, AC012571.3, AC025009.2, AC009899.5, AC020565.4, ACOl 1642.5, AC025346.1, AC021141.2, AC015950.2, AC017056.3, AC021047.2, AC019648.1, AC007432.7, AC009437.1, AF129075.1, AL356137.2, AL356322.1, AL162716.4, AL109751.18, AL160265.4, AL137144.4, AL355386.1, AL354778.1, AL137074.4, AL157365.3, AP002083.1, AP002013.1, AP001841.1, AP001569.1, AP001365.1, AP001356.1, SEQ ID NO: 431 ZH1110/T7

NM_015642.1 , AL050276.1, AFl 94030.1 , AFl 85576.1, AC008372.6, AC005874.3, AC007766.1, AF134471.1 , D88148.1, AE003835.1, AC007225.2, AC005214.1, AL133258.16, AL163225.2, AL034559.3, AP001680.1, APOOl 138.2, AA834935.1 , AW293260.1 , AI798849.1 , AI240155.1, AA083812.1 , N26227.1 , AI809178.1 , AA930334.1 , AA828063.1 , AA943003.1 , AWl 08541.1, AI551088.1 , AI626969.1 , N71750.1 , AI445139.1 , N99462.1 , AV028027.1 , AI809910.1 , AA613636.1, AV137484.1, AV329304.1, AV330564.1, AV329353.1, AI610886.1 , Tl 2777.1, AWl 15543.1, R93225.1, H02904.1, AW772943.1 , AW601219.1, AW483664.1, AW250685.1 , AW249227.1, C77465.1, AC068938.1, AC068072.7, AC025676.2, AC021032.3, AC068659.1, AC036186.2, AC010287.5, AC009164.3, AC009130.5, AC009093.5, AC008758.3, AC027250.2, AC024721.4, AC007615.3, AC021792.2, AC025394.2, AC0121 1 1.3, AC009270.2, AC015958.3, AC017038.5, AC023980.2, AC010583.3, AC022023.2, AC018792.2, AC011279.1, AL157833.5, AL136172.14, AL355594.3, AL135903.2, AL033383.25, AL158014.4, AL160280.2, AL157827.3, AL137848.1, AL138831.2, AL157883.2, AL136309.3, AL133461.2, AP001780.1, AP000853.1, AP000580.2, AC012520.8, AC046140.4, AC026763.5, AC048337.4, AC067852.1, AC027810.2, AC021443.5, AC022715.2, AC021369.3, AC02531 1.2, AC019313.3, AC024619.2, AC010687.2, AC020372.1, AC012281.1, AC007896.1, AP000874.1, AP000562.2,

SEQ ID NO: 432

ZH118 T3

NM_001278.1, AF080157.1, AF009225.1, AF012890.1, U22512.1, NM_007700.1 , U12473.1, AC012147.7, AE003769.1, AF227841.1, AC009888.1, AL132641.2, AL049775.2, AL132986.2, AF127936.2, AC010685.3, AC006730.1, AE003493.1, AC009464.7, AC007377.3, AF130351.1, AC007785.1, AL355094.2, AL163257.2, AL163207.2, AL132853.1 , AL121808.2, AL135745.2, AL121774.3, AL031768.9, AL096710.8, AL078473.2, U29521.1 , U29450.1, AP001712.1, AP000213.1, AP000031.1, AP000255.1, AP000135.1 , AW61 1010.1, AW822592.1, AA512576.1, AW159773.1, AW159313.1, AA721189.1, AV400040.1, AI553167.1, AU004118.1, AA518188.1, AA109551.1, R03450.1 , AW769650.1, AW497368.1, AW496881.1, AW485684.1, AW344422.1, AT001962.1, AI241905.1, AI200843.1, AI037034.1, AA704752.1, AA660505.1 , ACOl 8783.3, AL138921.6, AC026883.2, AL158168.5, AC018351.8, AC015797.2, AC027704.2, AC027438.2, AC024130.3, AC012204.3, AL050344.25, AL355517.2, AP001963.1, AP001816.1, AC041002.1 , ACOl 1259.3, AC021846.3, AC012202.2, AC002489.1, AL133313.1, AC016962.8, AC061978.2, AC026270.2, AC068854.1, AC068368.1, AC024134.2, AC025661.2, AC010941.3, AC013497.4, AC021403.4, ACOl 1755.3, AC022238.1, AC010129.2, AC013189.1, AC004071.1, AL353645.2, AL139216.4, AL136362.2, AL356094.1, AL353764.1, AL139020.1,

SEQ ID NO:433 ZH118/T7 AF080157.1, AL133012.1, NM_007700.1, U12473.1 , AC005831.1, AB019534.1, AC008164.3, AC004801.1, AL035078.32, AL031733.3, AC003683.1, Z97632.1, AL032654.1, AJ235272.1 , AC009498.3, AC007246.3, U41538.1 , ALl 36418.2, ALl 10487.1 , ALl 39054.1 , X69484.1 , AC008417.3, AC004125.1 , AC005230.1 , AF039082.1 , U50529.1 , AL033547.7, AL031798.1, AL022398.1 , AL109613.1 1 , AL009050.9, U80441.1, Z96104.1 , AC009424.2, AC006032.2, AC006299.1, AL133512.10, AW780178.1, AI763039.1, AW271579.1, AW237549.1, AA743087.1, AI148163.1,

AI306448.1, W38922.1, AA047462.1, AI082138.1 , AA398648.1, AW006992.1, AI300129.1, AI968640.1, AW009015.1, AI311794.1 , N94750.1 , AW298757.1 , AI261452.1 , H04646.1 , N49180.1 , AI039207.1 , AA759032.1 , R37348.1 , N29132.1 , AA747405.1 , AI953544.1 , AI991366.1 , H02318.1 , AA744487.1 , R22181.1 , R63099.1 , AA868823.1 , R26178.1 , R63149.1 , R26420.1, AI630705.1, T10670.1, R22180.1, AI829429.1, AI410474.1, AI408983.1 , AW701142.1, AI225339.1, AA276153.1, AA204533.1, AA217073.1 , AI324361.1 , AA152883.1, AI528668.1, AA183300.1, AA289029.1,

AW823505.1, AA945959.1 , AA084869.1 , AW785016.1 , AA617021.1, AW552155.1, AI234361.1, AA512576.1, AV225898.1, AA818928.1, AI505683.1, AA437895.1, AV380532.1, AV331321.1 , AV307290.1 , AU045682.1, AU044796.1, AU044266.1, AI256658.1 , AA085015.1, AA070210.1, AV375846.1, AV302964.1, AV126809.1, W39998.1, AV370274.1, AV314653.1, AV107765.1, AV068797.1, AA087827.1, AA656892.1, AV314950.1, AV068813.1, AW775907.1, AI930381.1, AI718289.1, AA778631.1, AA403202.1, AL138921.6, AC026424.2, AC008587.4, AC012213.3, AC04481 1.2, AC009485.2, AC027548.2, AC018718.4, AC010987.4, AL138970.6, AC009857.2, ACOl 1771.3, AC010952.3, AC022002.2, AC023451.2, AC010963.2, AC010817.1, AL157688.3, AC012592.5, AC021101.3, AC001233.1, Z98867.1, AC051652.2, AC024126.1, AC024123.1, AC023019.1, AL139353.1, AC055786.2, AC010600.3, AC00961 1.3, AL138762.5, AC068981.1, ACOl 1086.4, AC040919.1, AC019064.3, AC015476.3, AC040975.2, AC032024.2, AC021568.4, AC022065.2, AC016386.3, AC023202.2, AC006718.1 , AL121957.7, AL137780.2, AL109947.5, AL139806.3, AL139391.2, AP001981.1,

SEQ ID NO:434 ZH1214/T3 D43948.1, X92474.1, AJ251 130.1 , AL022397.1, AC007462.2, AF015750.1, AB0181 16.1, NM_016121.1, AC012262.14, AF155110.1, AF126811.1, AE001705.1, U46575.1, U97404.1, AL133485.1, AL034561.4, Z98255.1, Z35331.1, U41510.1, D78638.1, AW875503.1, AV262782.1, AI680593.1, AA330998.1, AA161253.1, AW875430.1, AI770288.1, R76393.1, AW779977.1 , AW636618.1, AW572796.1 , AW340052.1 , AW264564.1 , AW264231.1 , AW264326.1 , AWl 95137.1 , AW193971.1, AW152577.1, AW150295.1, AW035488.1, AW009806.1, AW008830.1, AW005644.1, AW001803.1, AI992833.1 , AI992162.1, AI984556.1 , AI967314.1, AI907040.1, AL037274.1, AI765832.1, AI686848.1, AL048814.1 , AI421765.1, AI398575.1, AI393364.1, AI339232.1, AI283161.1, AI277807.1, AU032822.1 , AI018124.1, AA978299.1, AA936410.1, AA929004.1, AA858164.1 , AA7801 19.1, AA772740.1, AA770301.1, AA448160.1, W81099.1, W81046.1, W58357.1, W45601.1, N41386.1, D57384.1, T30120.1, AC055841.2, AC020704.3, AL157363.3, AL355599.2, AC009232.2, AC044855.2, AC012314.5, AC022166.4, AC016238.2, AC069065.1, AC069035.1, AC018827.4, AC015565.3, AF189005.1,

SEQ ID NO:435

ZH1214/T7

.X92474.1, D43948.1, AJ251130.1 , AF061744.1, AF001863.1, AF102850.1, U48696.1, AF045432.1, AJ243486.1, Y16849.1, AJ243656.1, U39066.1, U37573.1 , Y16299.1, X99058.1, X99060.1, X99051.1, X99057.1, X99056.1,

X99052.1, Z97178.1, Y16851.1, AF033096.1, U48697.1, AFOl 1573.1, X99055.1, AJ270223.1, X99054.1, X99053.1 , AF128444.1, Y17148.1 , Y07542.1, AF224771.1, AF184239.1, U23715.1 , AL161559.2, AL031326.1, AC000095.3, AC002522.2, AC004461.3, L77570.1, AL031430.1, AL109939.13, AC000121.1, AF146603.1 , AE003700.1, AC000092.1, AC004099.1 , AC004231.1, U82964.1 , AL031277.1, U30368.1, X73502.1, X73501.1 , AW374979.1, R14180.1, AW407477.1, AW176568.1, AW239387.1 , W27586.1, AA805103.1, AA767900.1, Z20910.1, AA094395.1, AA568734.1, AA299590.1, Z19789.1, AJ396976.1, AW409741.1, AI857031.1 , AI857046.1, AI816693.1, AI816668.1, AI816651.1, AI815345.1, AI816702.1, AI816701.1, AI816700.1, AI816699.1, AI816697.1, AI816696.1, AI816695.1, AI816694.1, AI816692.1, AI816690.1 , AI816689.1, AI816688.1, AI816667.1, AI816664.1 , AI816663.1, AI816662.1, AI816661.1, AI816660.1 , AI816659.1, AI816658.1, AI816657.1, AI816656.1, AI816655.1, AI816654.1, AI816653.1, AI816652.1, AI816650.1, AI816649.1, AI816648.1, AI816647.1, AI816646.1, AI816645.1, AI816644.1, AI816643.1, AI816641.1, AI816640.1, AI816639.1, AI816638.1, AI815377.1, AI815376.1, AI815375.1, AI815374.1, AI815373.1, AI815371.1, AI815370.1 , AI815369.1, AI815368.1, AI815367.1 , AI815366.1 , AI815365.1, AI815363.1, AI815362.1, AI815361.1 , AI815360.1 , AI815347.1 , AI815344.1 , AI815343.1 , AI657485.1 , AA933356.1 , AA933350.1 , AA933216.1 , AA933125.1 , A A933095.1 , AA933094.1 , AA660699.1 , N83963.1 , AI815364.1 , AI816698.1 , AI816642.1 , AI446849.1 , AI353568.1 , AA933275.1, AA933111.1 , AA933353.1, AA933184.1, AW455598.1, AI617314.1, AI354018.1, AI353756.1, AC012054.1, AC018448.8, AC041O23.2, AC068800.3, AC009452.9, AC026031.3, AC024663.3, AC068617.1 , AC026659.3, AC027191.2, AC027O65.2, AC025309.2, AC026522.1, AC024628.2, AC010187.6, AC023800.3, AC017028.5, AC068493.3, AC037481.2, AC023859.2, AC022133.3, AC010218.4, AC008680.3, AC008665.3, ACOl 1500.5, AC027735.2, AC009786.2, AC026990.2, AC025484.2, AC022357.3, AC022705.3, ACOl 1226.3, ACOl 1795.4, AC017007.5, AC020586.2, AC015529.3, AC021694.2, AC013786.2, AC016820.2, AC022281.1, AC014336.1,

AC016381.1, AL137003.2, AL159970.7, AL138890.3, AL139004.3, AL355839.1, AL355497.1, AL161447.4, AL138795.1, AP001947.1, AP000812.1, AP000665.1,

SEQ ID NO:436 ZH1217/T7

M14660.1, AC006437.4, AC006560.8, AF091596.1, AC000348.2, AC016951.9, AC010252.3, AC008854.3, AC007878.2, AC007178.5, AE003561.1, AC006024.1, AC007463.3, AC002330.1, AF131858.1 , AC004352.1 , AC001645.1, AL161541.2, AF000198.1, AL138649.1, Z70756.1, AL132965.1, AL049745.9, Z97338.2, U00063.1, AK001541.1, AK001417.1, AP000386.1, AP000373.1, AB016873.1 , AB012244.1 , AC005155.1, AC007200.1, AC006952.6,

AC005610.1, AL096712.20, Y17293.1, AP000884.1, AA131041.1, AI458848.1, AI740602.1, AI140291.1, AI620542.1 , AI338018.1, N63988.1, AI373569.1, AI446658.1, N51262.1 , AA975115.1, AA134105.1, AA810945.1, AA854597.1, AW337373.1, AA056431.1, AI301531.1, AI261334.1 , AA866128.1 , AW272913.1, AI469715.1, AI080333.1, AA976884.1, AI770049.1, AA516150.1, AA484050.1, AA130252.1, AA765174.1, AI924290.1, AA811287.1, AV383770.1 , AW232841.1, AWl 90734.1 , AW725886.1, AA847944.1, AA188141.1, R84767.1, AW623261.1, AW443728.1,

AW316855.1, AW241933.1, AW034720.1, AI985531.1 , AI978628.1 , AI956080.1 , AI897778.1, AL043557.1, AL043510.1, AI698209.1, AI679174.1, AI611067.1, AI572570.1, AI570861.1, AI552591.1, AI527468.1, AA875645.1, AI367193.1, AI263737.1, AI247560.1, AI168145.1, AI120817.1, AI040092.1, AA780998.1 , AA725576.1, AA723350.1, AA652386.1, AA493515.1, AA486562.1, AA316491.1, AA040803.1 , W23971.1, W05624.1, N58119.1 , N38766.1, H85097.1, H39883.1, AL353751.3, AC021882.3, AL136526.15, AC068012.1, AC018910.4, AL021148.1, AC021057.4, AC051628.10, AC008613.4, AC009196.i l, AC010816.3, AC010949.2, AC008677.4, AC062038.1 , AC068395.1, AC027463.2, AC012221.3, AC027078.2, AL162501.2, AP001531.1 , AP000920.1,

SEQ ID NO:437 ZH1217/T3

M14660.1, X77259.1, NM_001549.1, U52513.1, AF083470.1 , AF026939.1, NM_008332.1, U43085.1, S77713.1, X07557.1, M14659.1, NM_010501.1, U43086.1, L32974.1, NM_012420.1, U34605.1, AE003505.1, NM_005691.1, AF061297.1, AL109939.13, AFl 16685.1 , AC009479.3, AC009241.3, AC008567.4, AC007969.3, AC010125.3, AC016939.8, NM_012768.1, AC002381.1, NM_001548.1, AC002565.1, AC004834.2, AC007759.1, AC005694.3, AC004765.2, AC005529.7, AC005527.3, AC006050.1, AC006134.1, AC004584.1, AC005195.1, AL163237.2,

AL121931.10, AC000388.1, AL031670.6, AL079304.2, AL132855.2, AL137669.1 , AL049795.20, AL133396.1, U69569.1, AL023879.1, AL049794.13, AL031388.1, Y18000.1, AP001692.1, M24594.1, X03557.1, AP001341.1, X94359.1, M69118.1, M16724.1, AA148160.1, AA054658.1, AA131155.1, AA135032.1, W74319.1, AW379473.1, AA200841.1, AW390730.1, AW378603.1, AA727519.1, AW763283.1, AA087306.1, AW378605.1, M77945.1, AA700017.1, AI928930.1, AW579659.1 , AW390720.1, W39498.1, AW163828.1, AI821192.1 , AI413442.1, AI133441.1, AI114693.1, AA619629.1, AA506010.1, AA249243. I, AA209431.1 , AA209430.1 , L26678.1, AL353751.3, AC016791.4, AC060826.2, AL353146.2, AL355342.2, AC037423.2, AC013781.3, AC027175.2, AC024459.2, AC016154.4, AC010204.9, AC064799.2, AC016526.3, AC021601.3, AC025854.2, AC016435.3, AC0I2186.3, AC024432.2, AC013432.3, AC019768.1, ACOl 1920.2, AL355604.2, AL354870.1, AL162393.2, AC012520.8, ACOl 1314.6, AC067724.3, AC046140.4, AC026763.5, AC051660.3, AC021032.3, AC027195.2, AC025467.3, AC027130.2, AC068506.1, AC027438.2, AC013734.3, AC009481.3, AC017014.3, AC009712.3, AC027523.2, AC026269.2, AC024130.3, AC024131.3, AC022737.2, AC026026.3, AC034194.1, AC016419.3, AC019058.3, AC012111.3, AC022020.3, AC021884.2, ACOl 1774.4, AC022826.3, AC013587.4, AC018881.4, AC020644.2, AC015912.3, AC024015.1, AC018979.4, AC018980.3, AC009985.5, AC012493.3, AC013721.3, AC012553.3, AC013476.3, AC016048.1, AC015650.1, AC002317.1, ALl 36987.2, AL355579.3, AL157713.4, AL353793.2, AC002345.1, AL354981.1,

AL354917.1, AL354833.1, AL160252.3, AL161723.3, AL158158.4, AL158011.1, AL137128.1, AP001873.1, AP001848.1, AP001637.1, AP000598.2

SEQ ID NO: 438 ZH1222/T3

NM_004506.2, M65217.1, NM_008297.1, X61754.1, AF172640.1, Z99129.1, AF045615.I, AF045618.1, L06125.1, AF045617.1 , AF045616.1, AF172641.1, L36924.1, AF045619.1, X61753.1, NM_005526.1, X55347.1, M64673.1, AF045620.1, AL035451.5, AC009227.3, AC007364.2, AC007193.1 , AC007124.1 , AC004812.1, U49511.1, AL163242.2, LI 1868.1, AL035698.12, AL050324.5, Z82200.1, AJ006397.1, Z83860.1 , APOO 1697.1, AP001601.1, L06098.1, AE002550.2, AE002206.1, AF124349.1, AE001616.1, AC005547.1, AF075603.1 , ALl 32641.2, AL139078.2, AL122003.17, AL033517.1, Z49274.1, L47649.1, D90910.1, AB018115.1, Z46953.1, M12897.1, AW352398.1, AL035756.2, AA362830.1, AL044736.1, AA888406.1 , AA354787.1, AW767522.1, AI002480.1, AI324484.1, AW640883.1, AW169960.1 , AW137844.1, AW135472.1, AW054829.1, AW016463.1, AW007349.1, AI934773.1, AI895934.1, AI863994.1, AI809542.1, AI703424.1, AI700961.1, AI692361.1, AI651222.1, AI628965.1, AI521804.1, AI393937.1, AI042312.1, AI055366.1, AAl 18488.1, AI295219.1, AV386944.1, AI373558.1, AI372231.1, AW854061.1, AW255279.1, AW233008.1, AI900223.1, AI881242.1 , AV082943.1, AI634255.1, C95479.1, AI477508.1, AA928989.1, AA913874.1, AA913417.1, AA811007.1, AA807625.1, AA771801.1, AA743736.1, AA723901.1, H73197.1, R94578.1, T93779.1, AC022207.2, AL121954.4, AL109916.3, AL138961.3, AC013581.4, AC062011.2, AC063945.3, AC009817.3, AC058817.3, AC022417.3, AC008473.3, AC023337.3, AC027697.2, AC019198.2, AC016173.2, AC007449.2, AC025891.2, AC018773.2, AC012564.2, AL138775.5, AL122002.14, AL35631 1.1, AL355302.3, AL079336.13, AL137859.3, AL355375.3, AL133330.7, AL162457.3, AP001997.1, AP001984.1, ACOl 1471.5, AC010614.4, AC067980.1, AC067916.1 , AC005038.2, AC009612.3, ACO27039.2, AC026082.3, AC021433.3, AC018791.3, AC024596.3, AC024037.2, AC021777.3, AC009792.4, AC0261 13.4, AC022898.3, AC025733.1, AC013768.4, AC019348.2, AC010732.3, AC014147.1, AF178220.1, AC007194.1, AC005051.1, AL353729.2, AL136959.2, AL157786.2, ALl 36302.6

SEQ ID NO: 439 ZH1222/T7 Z99129.1, NM_004506.2, M65217.1 , NM_008297.1, AF045627.1, X61754.1, AF172640.1, AL163912.1, Z68160.1, L41499.1, U40424.1, D17366.1, ACOl 1809.2, AC008126.9, AC000104.1, AL133216.10, Z92844.1, AC002329.2, AE003811.1, AE003525.1, AE003517.1, AE003486.1, AE002786.1, AC018748.3, AF102707.1, Z83318.1, AI92391 1.1, AI990935.1 , AI203377.1, AI056677.1, AW269952.1, AI989487.1, AI472020.1, AI524322.1, AI700694.1, AI561266.1 , AI979106.1, AW008963.1, AW468756.1 , AWl 83922.1, AI688920.1, AA905319.1, AI690727.1, AA707596.1, AI499774.1, AA551748.1, AA551757.1, AI536850.1, AA969316.1, AI480249.1, AA253434.1, AA832045.1, AI270358.1, AI810705.1, AI433107.1, AA651949.1, AA969392.1, N39221.1, AA868883.1, AI142644.1, AL035757.1, AA136344.1, AI453040.1, AA860985.1, AA913304.1, AA9I3486.1, AW468554.1, R39144.1, AA815117.1, AI473089.1, H24055.1, AI539466.1, AA971072.1, T53314.1, H72024.1 , R46149.1, D53854.1 , D52415.1, AW028964.1, H72025.1, AA250730.1, D52616.1, D52419.1, H14792.1, F04785.1, T29491.1, N46665.1, C20787.1, T53313.1, AW142847.1, AI740594.1, AI230246.1 , All 67251.1, AA944812.1 , AI661205.1, AA268498.1 , AV259149.1, AA832774.1, AI962803.1, AI556468.1, AA818911.1, AI170959.1 , AI010919.1, AI102092.1, AL121954.4, AL109916.3, AC027000.2, AC068022.1, AC027082.2, AC024345.2, AL049180.3, ACOl 1602.6, AC027648.6, AC025854.2, AC027355.1 , AC022387.2, AC022480.4, AC025302.2, AC009754.3, AC009816.5, AC024260.1, ACOl 1683.3, AC010660.4, AL121954.4, AL109916.3, AC027000.2, AC068022.1, AC027082.2, AC024345.2, ALO49180.3, ACOl 1602.6, AC027648.6, AC025854.2, AC027355.1 , AC022387.2, AC022480.4, AC025302.2, AC009754.3, AC009816.5, AC024260.1, ACOl 1683.3, AC010660.4

SEQ ID NO: 440 ZH1233/T3 AB006198.1, Y14314.1, AB014722.1 , AB014721.1, AF129931.1 , AF147725.1, AC007915.3, AF028338.1 , L20095.1,

L20680.1, NM_015933.1, ACOl 1462.4, AE003765.1 , AC000029.17, AF161448.1, AF077202.1, U39402.1, AC004196.1, U67478.1, AL163816.1, Z97832.11, AL049853.1, ALl 12418.1 , AL021930.1. L09190.1, AKOOl 152.1, AB023212.1, M15100.1, AB017022.1, W27222.1, AW402760.1, AL047890.1, AI594593.1, AW820827.1, AA607769.1, AI120962.1, AI509410.1 , AI908693.1, AW393484.1 , AW652595.1, AI964608.1, AA979854.1 , AA979772.1 , AI661459.1, AI642054.1, AJ228935.1, AA751847.1, AW758324.1, AI827037.1, AV417239.1, AW674436.1, AW615491.1, AW245981.1,

AW074946.1 , AW006944.1, AI924762.1, AI880663.1, AI880658.1, AI709253.1 , AI708293.1, AI708235.1, F33596.1, F30411.1, F28809.1, F28190.1, F27897.1, AI666115.1, AI570650.1 , AI459983.1, AI418553.1, AI370584.1, AI364309.1, AI339191.1, AI333234.1, AI290693.1, AI090805.1, AA910393.1, AA563619.1, AA364686.1, AA321138.1, AA280277.1, AA279851.1, AA229404.1, AAl 51350.1 , AAl 49268.1, AAl 34303.1, AA082333.1, AA046848.1, AA026455.1 , W95678.1, W76586.1 , W51757.1 , W04465.1 , N84053.1 , N80509.1 , N78206.1 , N76058.1 , R07233.1 , T91349.1 , T80989.1 , AP001201.4, AP000592.2, APOOl 191.1, AP000586.2, AC008683.4, AC018996.3, AC046141.3, AC068951.1, AC022120.4, AC008405.3, AC008658.2, ACOl 1069.6, AC013189.1, AC055744.2, AC068667.3, AC027309.2, AC027307.3, AC022091.3, AC010377.4, AC008453.4, AC008450.3, AC064317.1 , AC064056.1, AC052499.1, AC044355.1, AC045178.1, AC041917.1, AC040463.1, AC034640.1 , AC028038.1, AC021328.3, AC021286.3, AC007903.2, AC026184.1, AC019127.4, AC018734.2, ACOl 1233.2, AC023950.2, AC010899.3, AC015903.1, AC014411.1, AC018045.1, AC006579.3, AL136136.2, AL1361 19.3, AL109955.13, AL135939.9, AL133282.13, ALl 33284.12, AL032818.2

SEQ ID NO: 441 ZH1235/T3

AJ236885.1, L04282.1, AF039019.1, U30381.1, NM_011749.1 , X98096.1, AJ001165.1, U80078.1, ALl 33244.1, AL121656.2, AC008125.9, AL049648.6, AC007444.1, AE003754.1, AC005552.1, AJ006687.1, AL038916.1, AI158501.1, AA967471.1 , AW261045.1, AW425025.1, AI093969.1 , AW667700.1 , AW619431.1, AW619430.1 , A W359900.1, AA911993.1, D86150.1, AC019289.3, AC032043.1, AC026618.1 , AC020598.3, AC019180.4, AC009770.4, AC023077.3, AC040911.1, AC034145.1 , AC023199.2, AC027362.1, AC026243.2, AL139189.4, AL354939.3, AL354985.2, AC069141.1, AC020609.4, AC016965.6, AC019074.3, AC026116.7, AC026441.2, AC024588.2, AC022113.4, AC016648.4, AC010308.4, AC022554.2, AC023560.2, AC021219.2, AC020787.2, AC007825.5, AC012075.3, AC016484.1, AC016965.5, AC019694.1, AC010120.4, AC012550.1, AL353575.3, AP001972.1 SEQ ID NO: 442 ZH1235/T7

AF039019.1, AJ236885.1, U30381.1, NM_011749.1, U80078.1. X98096.1 , AJ001165.1 , U96633.1, L04282.1, AE003673.1, AF214658.1, AE001574.1, AC005379.1, AC002512.1, AC005817.7, AC004005.2, AC003063.7, AF181967.1. U90222.1, AFl 13957.1, AC004189.1, U97191.1, Z81052.1, AJ245414.1, AJ012638.1, AJ012636.1 , AP000517.1, AB023055.1, AB023054.1, AI263859.1, AA563588.1 , AI056295.1, AA287619.1, AI743361.1, AW779476.1, AI384073.1, AI382374.1, AW051393.1 , AA613057.1, AA943882.1, AI848462.1, AI323627.1, AW272463.1 , AW772534.1 , H 12745.1 , AW823563.1 , AAl 10786.1 , AI467973.1 , AI283469.1 , AI077636.1 , AI003273.1 , AA622568.1 , AA552124.1, AA192099.1, AW732203.1, AI955302.1, AI955293.1, AI696880.1, AI283452.1, H70711.1, AA764105.1, AI393951.1 , H12746.1, AI864852.1, AW214414.1, AI589987.1 , AA631 1 15.1, C06563.1, AI202723.1, AI030160.1, AA661593.1 , AA414802.1, T81259.1, AI806680.1 , AW229224.1 , AV147450.1, AI502057.1, AI318282.1 , N27696.1 , AI092457.1 , AV250724.1 , Al 179647.1 , AI591356.1 , AW313771.1 , AA811939.1 , AA219846.1 , AW003751.1, AI823800.1 , AI819198.1 , AA887801.1 , AW850285.1, AW850147.1 , AW805474.1, AI729407.1, AI729074.1, AH 15405.1, AA793995.1, W43508.1, AA416406.1, AA041084.1, Z34722.1 , T02803.1, AC019289.3, AC055752.5, AC026618.1, AC068071.3, AC009282.2, AC023583.2, AC020313.1, AL133266.4, AL049597.28, AL158137.1 , AC022334.11, AC025069.3, AC015840.2, AC022401.2, AC018966.3, AC023396.2, AC022526.4, AC023271.3, AC026396.1, AC022534.4, ACOl 1737.3, AC009703.2, AL355532.4, AL157823.3, AL109917.1, AP001257.1

SEQ ID NO: 443 ZH1239/T3

NM_006431.1, AF026166.1, AF026293.1 , AB041570.1, NM_007636.1, Z31553.1, U91327.1, AB022156.1, U25632.1, AE003446.1, AL031 174.1, Z69239.1, Z98547.1 , NC.001142.1, L47993.1, Z49564.1, NM_014680.1, AC007030.3, AF077407.1, AC005726.1, AC004807.1, AL157421.1, D43947.1, U46030.1, AC004768.1, U67606.1, AL021939.1, U21308.1, AF025703.1, AL032653.1, AL049823.14, AL031268.1, AL096773.6, U15667.1, AB025613.1, AB015478.1, AB008158.1, AL037847.1, AA314410.1, AL037869.1, AA307298.1, AW403677.1, AA308098.1, AA188046.1,

AA242864.1, AI027493.1, AA081834.1, W05515.1, AA160646.1, W45121.1, AA313512.1, AA232345.1, AA361372.1, AA353331.1, AA224141.1 , AA053093.1, AA329489.1, AA332992.1, AA295347.1, AA357480.1, AA852740.1, AW673301.1, AA319426.1, AA312375.1, AW238978.1 , AA305205.1, AW673381.1, AA356819.1, AA330679.1, AA375669.1, AA300800.1, AW140939.1, AA375100.1, AA331858.1, AA356680.1, AW673279.1, AI882004.1, W54494.1, AI788163.1, AW210350.1 , AI652229.1, AI216294.I , AA646398.1, AA592229.1 , AW403775.1, AA162607.1,

AA162606.1, AW611267.1, AA144722.1, AW611275.1, AI787901.1, AU066662.1, AA274498.1, AI155006.1, C89118.1, AA796937.1 , AI041880.1 , AW392797.1 , AA779219.1 , N87565.1 , AA376043.1 , AA036458.1 , AA357218.1 , D77137.1 , AA289702.1, AA869807.1, H34906.1, AA686674.1, AA003927.1, AA707035.1, AA331462.1, AW753648.1, D81695.1, AW784181.1, AI082436.1, AA069953.1 , N84531.1, AA144256.1, AW259083.1, AA376428.1 , AI240672.1, AW259750.1, AA209312.1, AA204777.1 , AW494677.1, AW646970.1, AI240700.1, D77545.1 , D21683.1, AV044678.2, AA370641.1, AA795229.1, AW328791.1, AA495708.1, AV146088.1, AW872232.1, AW872111.1, AC018921.6, AC015519.1 , AC016153.4, AC013068.1, AC023802.7, AP000878.1, AC015972.3, AC008702.2, AC012297.3, AP000791.1, AC068562.1, AC044804.1, AC026955.2, AC019024.3, AC023114.3, AC016282.3, AC016750.4, AC018804.2, AC024228.1, AC021930.1, ACOl 1129.3, ACOl 6702.1 , ALl 17349.9, AL020986.14, Z92862.1

SEQ ID NO: 444

ZH1239 T7

NM_007265.1, D88208.1, AEOOl 159.1, AC006805.1, AC004009.1, AF072698.1, AL034560.3, AL049543.14,

AB010374.1, ABOl 03 1.1 , AC008417.3, AE003790.1, AE003701.1, AE003583.1 , AC009503.3, AF229187.1, AC000134.14, AC022288.3, AF133290.1, AC016831.1, AF181897.1, AF053720.1, AC004673.1, U93237.1, AF017104.1, U78486.1, AC004340.1, AL021 127.2, AL 136329.1 , X98999.1, AL161582.2, AL161531.2, Z22181.1, AL096882.2, AL049876.1, Z81533.1, Z84480.1 , AL112418.1, Z98547.1, AL118618.1, AW612468.1 , AW301001.1, AI174590.1, AI655550.1, AI636702.1, AA582125.1, AA088312.1, AI469061.1, AI129538.1, AW205982.1, AI797450.1, N78688.1 , AW023577.1, W58626.1, AA457335.1, AW372225.1 , AA701351.1, AW372193.1 , N77826.1, T80582.1 , AA894689.1, AI796367.1, AA628695.1, N48358.1, H58914.1, AI640878.1, AI289462.1, AW578536.1, AA932627.1, H73007.1 ,

N99779.1, AI498752.1, H60477.1, AW361402.1, W58522.1, AW298385.1, R23840.1, AI932464.1, N75855.1, R06296.1, AI587257.1 , AA385517.1, AW130718.1, N49135.1, AA457241.1, AA026122.1, AI599581.1, AI599061.1, W15195.1, AI932906.1, R06355.1, AW604635.1, AW434542.1, AI890809.1, AI103741.1, AI103538.1, AI044220.1, AW764290.1, AW701 196.1, AW555241.1, AW372223.1, AW261516.1 , AW120503.1, AU021426.1, AU019817.1, AA832867.1, AA470301.1 , AU021511.1, AW555246.1 , W14079.1 , AW558345.1, C87021.1, C86542.1 , AA691666.1, AI425788.1, W80276.1, AW492846.1, AA899803.1, AW358584.1 , AA16O802.1, AA958403.1, AA981089.1, AA026589.1, AA30541 1.1, AI931978.1, AA259679.1, AW058691.1, AI882965.1, AI545385.1, AI020739.1, AW749441.1, AV260861.1, AW045116.1, AI883113.1, AV151030.1, AA818759.1, AA717672.1 , AC068557.1, AC016394.3, AC009938.2, AC015617.3, AC015593.2, AC068914.1, AC021559.3, AC021784.2, AC010947.3, AC026255.1, AC010899.3, AC010826.2, AL121946.14, AL121932.15, AL157774.5, AL136380.2, AL355991.1, AP000813.1, AP000562.2, AC068537.2, AC064822.3, AC016776.2, AC026031.3, AC027338.2, AC027327.2, AC010586.4, AC012607.4, AC016585.2, AC008767.4, AC009563.3, AC037454.2, AC019030.4, AC019212.3, ACOl 1121.4, AC027248.2, AC027086.2, AC025272.4, AC016780.5, AC021264.3, AC025292.6, AC010781.3, AC019351.3, AC021356.5, ACOl 1046.3, AC020674.4, AC023021.2, AC021557.3, AC021395.2, AC007646.7, AC018503.4, ACOl 1912.3, AC015490.3, AC007669.5, AC007650.6, AC019877.1, AC020443.1 , ACO 17830.1, AC007976.3, AC007549.4, AL109742.3, AL355528.3, AL159984.3, AL162274.4, AL049915.1, AP001187.1

SEQ ID NO: 445 ZH1246/T3 AJ012494.1, AB016873.1, AC007359.2, AC016752.2, AC013428.4, ACOl 1560.4, AC008175.2, AF123280.1,

AL035670.29, AL031746.9, Z54218.1, AL049653.7, AB024028.1 , AC005659.3, AF140042.1, AF149413.1, AF069772.1, U48386.1, U32770.1, AL161667.1, AJ276875.1, Z92788.1 , S93804.1, Z28117.1, AP000953.2, M73805.1 , AC005957.2, AC004988.2, U73479.1, AL163852.1, AL162751.1, AL050343.17, AI316374.1, AA122754.1, AI596711.1, AA168500.1, AA684283.1, AI339046.1, AI275145.1, AA334894.I , R50891.1, R53342.1, R15006.1, AW413196.1, AA543789.1, AA017943.1, AW456131.1, AA604894.1, Z84094.1, AW489233.1, AA827713.1, AA807856.1, AA971922.1 , AA55I525.1, AW215047.1 , AI715142.1, AW395964.1, AW654477.1, AA280722.1, N98571.1 , H85699.1, R81264.1, T32856.1, AW703298.1 , AI993962.1, AI938007.1, AI227746.1, AV420160.1, AW739118.1 , AW728338.1 , AV442499.1, AW585568.1, AW584470.1 , AV330786.1, AW159353.1, AI736567.1, AI563324.1, AI440892.1 , C83974.1, AA672822.1, R80012.1 , T38739.1, T38590.1, AW772878.1, AW766054.1, AW765344.1, AW765211.1, AW720989.1, AW676320.1, AW676023.1, AW638856.1, AW429129.1 , AW228541.1, AV393578.1, AV393030.1 , AV392207.1 , AV391210.1, AV389867.1 , AV389618.1, AV387850.1, AV387379.1, AV386705.1, AW216033.1, AW066715.1, AW032959.1, AW017507.1 , AI896863.1 , AU060616.1 , AI665500.1 , Al 111896.1 , AA542534.1 , C09510.1 , D34272.1 , ACOl 8463.4, AL161611.3, AC037474.2, AC026068.2, AC069100.1, AC025246.5, AC023342.2, AC008061.1, AC007965.2, AC007315.2, ACOl 1353.3, AC025722.1, AL353780.2, AL160280.2, AL139346.1, AC063945.3, AC068545.2,

AC068642.2, AC032011.3, AC026607.2, AC025515.2, AC016215.4, AL136233.3, AL355886.1 , Z92853.1, AC027652.6, ACOl 1195.4, AC007990.2, AC020704.3, AC025479.2, AC013288.1, AL354875.3, AL354682.1, AL031745.7

SEQ ID NO: 446 ZH1246/T7

AF131838.1, AL109628.2, AC008430.3, AC003991.1, U91322.1 , AF007544.1, AL133371.2, Z98049.1, D00403.1, NM_003368.1, AC007678.3, AE003774.1, AC003087.1 , AC006376.2, AC005510.3, AFl 17386.1 , AC004655.1, AF036876.1 , AL049553.20, ALl 17575.1 , ALl 17503.1, U82694.1, AL035411.27, AL109946.12, Z70274.1 , ALl 09750.5, AL021997.1, AL035671.5, S57147.1, U39854.1, Y13535.1, AB014458.1, AA046864.1, AA4601 17.1, W56251.1, AW770864.1, AW274585.1, AW274012.1, AA121005.1, AW340730.1, AA838074.1, AA025284.1 , AA463813.1,

AA025509.1, W72220.1, AA758578.1, AA865270.1, AI093268.1 , AI809015.1, AA576920.1, AA046616.I , W79406.1, W77964.1, AA765645.1, AI469964.1, AI090504.1, N28710.1, AI215777.1, AW069815.1, AI091875.1, AA575900.1, W37590.1, AI081436.1, AA195169.1, AI262012.1, AI086990.1, AI086986.1, AI090622.1, AI688371.1 , AA553947.1, AI066619.1, AA744747.1, AI025326.1, AW085263.1, W79519.1, AI687571.1, AI359261.1, AI301033.1, AI129737.1, AA666117.1 , AA778035.1, AW662808.1 , AA935141.1, W03467.1, AA150876.1, AI263263.1, AI480217.1, AI671927.1, AL120648.1, AI811977.1, AA731247.1, W44726.1, T33329.1, R53947.1, AA252057.1, N67493.1, AI305238.1, AI358639.1 , AAl 15937.1, AA025323.1 , C02044.1, AW779054.1, T73883.1, W60503.1, AA810051.1, AA652737.1 , AI089304.1, W38658.1, AI751448.1, T87823.1 , H38074.1, AA460249.1, AI798193.1, T47322.1, AI963475.1, AH 86363.1, AA580432.1, AI911053.1, AA082082.1, AI610212.1, AA150749.1, T71930.1, AI216841.1, N49501.1, AA863123.1 , AA971960.1, AA730902.1, AA749453.1, AA461469.1, AA528506.1, AA994639.1, Z38836.1, AC026068.2, AL161420.5, AL353574.2, AL161611.3, AC018569.3, AL162255.5, AL133479.9, AC018801.3, AC013780.3, AC024170.1, AC022808.1 , AL161450.4, AL354809.1 , AF217246.2, AC026365.3, AC010323.4, AC008110.2, AC034234.1, AC019323.3, AC024234.4, AL355151.3, AL136322.2, AL355922.1, AL354874.1, AL162372.3, AP001009.1 , AP001525.1, AC055882.3, AC027320.2, AC010255.4, AC010309.4, AC010441.4, ACOl 1406.2, ACOl 1408.4, AC008643.3, AC008475.4, AC008450.3, AC034120.2, AC025008.2, AC026977.2, AC027052.2, AC040938.1, AC018945.3, AC025396.2, AC025119.2, AC021971.3, AC023085.2, ACOl 1178.3, AC016008.3, AC015917.4, AC020171.1, AL157376.2, AL356432.1, AL356133.2, AL136224.4, AL355389.1, AL354894.1, AP001836.1

SEQ ID NO:447 ZH1252/T3

NM_014570.1 , AL159143.1, AF111847.1, AL137598.1, AL049758.i l, AK002083.1, AFl 89776.1 , AFl 89775.1, AF189774.1, AF189773.1, AL022328.21, Z95703.1, AC007920.18, AE003635.1, AE003419.1, NM_005593.1, AC007743.3, AF158386.1, AF158385.1, AL158061.1, AL121806.2, X87247.1, X14894.1, L00676.1 , M95285.1, AI064747.1, AW407642.1, AA448950.1 , AAl 33150.1, AA128508.1, AA223442.1 , AA917502.1, AW407332.1, AA98801 1.1, W14832.1, AA792131.1, AI390883.1, AA984552.1, AW389654.1, F14772.1 , AW785941.1, AW159059.1, AW795979.1 , AI417756.1, AW675393.1, AW410339.1, AW403045.1, AW163692.1, AW163450.1, AW160901.1, AA871254.1, AA350230.1, AA346899.1, AA323938.1, AA295297.1, W53209.1, AJ398955.1, AJ396546.1, AJ394216.1, AA51 1562.1, H29613.1, R27796.1, T85026.1, AA249594.1, W96489.1 , Z82199.1, AC024558.7, AC068818.1, AC024045.3, AL139226.14, AL121881.30, AC021873.7, AC008128.7, AC069069.2, AC068763.2, AC068299.4, AC025568.3, AC018752.3, AC010396.3, AC018694.3, AC022912.3, AC046154.1, AC015671.3, AC026759.1, AC012308.4, AC015889.3, AC023283.3, AC021257.2, ACOl 1306.4, AC012479.2, AC014140.1, AC020218.1, AL162422.2

SEQ ID NO:448 ZH1252/T7

NM_014570.1, AL159143.1, AFl 1 1847.1, AL137598.1, AL049758.i l, AK002083.1, AF189776.1, AF189775.1, AF189774.1, AF189773.1, AL022328.21, Z95703.1, AC007920.18, AE003635.1 , AE003419.1, NM_005593.1, AC007743.3, AF158386.1, AF158385.1, AL158061.1 , AL121806.2, X87247.1, X14894.1, L00676.1, M95285.1, AI064747.1, AW407642.1, AA448950.1, AA133150.1, AA128508.1, AA223442.1, AA917502.1, AW407332.1, AA988011.1, W14832.1, AA792131.1, AI390883.1, AA984552.1, AW389654.1 , F14772.1, AW785941.1, AW159059.1, AW795979.1, AI417756.1, AW675393.1, AW410339.1, AW403045.1, AW163692.1, AW163450.1, AW160901.1, AA871254.1 , AA350230.1, AA346899.1 , AA323938.1, AA295297.1, W53209.1, AJ398955.1, AJ396546.1 , AJ394216.1, AA511562.1, H29613.1, R27796.1, T85026.1, AA249594.1, W96489.1, Z82199.1 , AC024558.7, AC068818.1, AC024045.3, ALI39226.14, AL121881.30, AC021873.7, AC008128.7, AC069069.2, AC068763.2, AC068299.4, AC025568.3, AC018752.3, AC010396.3, AC018694.3, AC022912.3, AC046154.1, AC015671.3, AC026759.1, AC012308.4, AC015889.3, AC023283.3, AC021257.2, ACOl 1306.4, AC012479.2, AC014140.1, AC020218.1, ALl 62422.2 SEQ ID NO:449 ZH1256/T3

AF069601.2, U48959.2, AF069603.1, AF069602.1 , NM_005965.1, X85337.1, AF042089.1, M76233.1, S57131.1, M76369.1, AF045269.1, M31048.1, X52876.1, U61731.1 , U08979.1, AC009238.3, AE003700.1, NM_003458.1, AF052224.1, Y18450.1, ACOl 1455.6, AF238310.1, AE003771.1 , AE003433.1, AE003420.1, AE003419.1, NM_010756.1 , AC004869.1, AC005903.3, AF184885.1, AC005684.1, AC005320.1, AC005368.1, U64857.1, Z54216.1, AL133315.1, AL132651.1, AL022017.1, AB009693.1, X54143.1, X06589.1, AI425007.1, AI220448.1, AW728163.1, AA241767.1, AW729690.1, AW727596.1, AW668218.1 , AW668079.1, AW214693.1, AW142383.1 , AI731262.1, AI642234.1 , AA567869.1 , AH 79188.1, AA674348.1, T87472.1, AC020634.4, AC023165.9, AC020634.3, AC026385.6, AC024888.5, AC016575.6, AC008391.3, AC016618.4, AC024386.3, AC021572.2, AC007723.4, AC012997.1, AC008360.2, AL353577.3, AC009321.5, AC026376.7, AC025809.2, AC007909.3, AC023403.2, AC021716.2, AC012508.3, AC016329.2, AC013858.1, AC014319.1, AC019499.1, AC012815.1, AC007892.3, AC007439.5, AC006915.1, AL080314.29, AL160289.3, AL133487.1, AP000923.2, AP000849.1

SEQ ID NO: 450 ZH1256/T7

NM_005965.1 , X85337.1, AF069601.2, U48959.2, AF069604.1, X90870.1 , AF069603.1, AF069602.1, AF096774.1, AF096775.1 , AF096773.1 , S57131.1 , S80867.1 , M76233.1 , AF096771.1, M76181.1, AF096770.1 , AF096769.1 , Y09530.1 , M76234.1, M14953.1, M96655.1, M31048.1, M88283.1, X52876.1, AF096768.1, M88284.1 , AF045285.1, M96987.1, AF096767.1, X52877.1, AL135784.4, AF045284.1, M88280.1, AE003492.1 , S76114.1, AC003998.1, AC005005.1, AF128893.1, AF121948.1, AF045281.1, AB016879.1, AC005743.5, AL050322.10, Z97181.1, AP000533.1, AC007089.3, AC005386.1, AC006949.8, AC004806.1, AF045283.1, AC005152.1, AC004791.1, AC006368.2, AC007297.22, U51243.1, AL163273.2, AL158059.2, AL138644.1, U61731.1, Z68330.1, AL034379.8, AL035466.3, AL021329.1, Z84465.5, AP001728.1, D86998.1 , AP000010.2, AE003817.1, AC022472.2, ACOl 1604.10, AF081666.1 , AF081665.1, AF081664.1 , AF081663.1, AF081662.1, AF081660.1 , AF081659.1, AF081657.1, AF081654.1, AF081650.1, AF081647.1, AC002101.1, AL133214.12, Z83820.1, J01209.1, AJ230973.1, M60486.1, AC002378.1 , AC006137.1, AP001412.1, AW439636.1,

AW152647.1, AA846544.1, AI095622.1, AA613660.1, AI042420.1, AI925396.1, AA454065.1, AA541652.1, AI186177.1, AW445149.1, W72714.1, W95026.1, AI125298.1, AA613440.1, AI187345.1, AW169345.1 , AI126911.1, AA595987.1, AA494344.1, Al 146909.1 , A A460946.1, AA461252.1, AI679797.1, AA991772.1, AI143142.1, AA594463.1, N99150.1, AA935323.1 , AI141982.1, AA635415.1, AI074102.1, AI041798.1 , AI167714.1, AA564147.1, AW470710.1, AA916523.1, AI927798.1 , AI268600.1, AA86.1048.1, AI302508.1, AI268755.1, AA142908.1, AI288810.1, AI263251.1, AI204679.1,

AWl 30308.1 , AA523611.1, AI658584.1 , AI768972.1 , AA652730.1 , AA564626.1 , AA535709.1 , W93341.1 , AA 127948.1 , AW272989.1 , AA722670.1, AA070691.1, AI078712.1, AI362419.1 , AI810438.1, AA487215.1 , AI769684.1, AW146368.1 , AA583542.1, H94293.1, AA573423.1 , AA230313.1, AI167999.1, AI747300.1, AI746549.1, AA065228.1, AA127982.1, T40866.1 , T40854.1, AA654746.1, T55741.1, AI123173.1, N78697.1, W21325.1, AA150910.1, AI880477.1, AA534955.1 , W25537.1, AW461776.1, AA297864.1, AA524623.1, T40860.1, AA706108.1 , AI462176.1, T94376.1, AA374739.1,

AW465934.1, AA487075.1, AA922346.1 , AA853392.1, T40844.1 , AA486775.1, T40852.1, AA099952.1, AC023165.9, AC021861.3, AC009434.5, AC019234.3, AC063967.1, AC013275.4, AC018865.1, AL160169.2, AC016942.5, ACOl 1606.6, AC026386.4, AC025087.3, AF252829.1, AC019218.3, AC023812.3, AC022220.4, AC021999.2, AC010993.10, AC010994.9, ACOl 1606.5, AC013198.1, AL132765.17, AC037473.2, AC058821.2, AC068489.1, AC027297.5, AC021248.3, AC016365.4, AC023404.2, AL162733.2, AC021871.8, AC044806.1, AC025966.2, AC025866.2, AC024647.2, AC016100.4, AC020616.3, AC002489.1, AL121930.10, AC064835.3, AC012055.6, AC036171.2, AC008985.5, AC008878.6, AC008758.3, AC025196.2, AC027731.2, AC060828.3, ACO20558.3, AC018714.3, AC006375.3, AC009470.3, ACOl 1 117.4, AC025549.3, ACOl 1034.3, AC022461.3, AC022673.3, AC018535.3, AC010583.3, AC023003.2, AC013261.2, AL355880.2, AJ239319.3, AL158207.3, AP001815.1, ACOl 1473.3, AC006927.22, AC024728.2, AC012186.3, AC019091.2, AC012502.2, AL1391 15.4, AF254136.1 , AL353142.3, AL162211.3, AC055874.2, AC034280.2, AC068203.1, AC022231.8, AC026958.2, ACOl 8629.3, AC027668.1, ACOl 1432.2

SEQ ID NO: 451 ZH1268/T3

NM_014673.1, D14659.1, AF146342.1 , AC004741.1, NC_001224.1 , AF152364.1, AL159140.2, AL161572.2, AJOl 1856.1, Z70680.1, AL031703.1 1, AC007878.2, AE003844.1, AE003787.1, AE003676.1, AE003519.1 , AE003422.1, AE003217.1 , AE002613.1, NM_008062.1, AC004926.2, AC005521.1, AC005004.3, ACOl 1713.2, AC006065.3, AF044676.1 , AL132641.2, AL162754.2, AL137228.2, U88534.1, AL021395.15, AL021406.1, U47058.1, AL078624.24, U59516.1, U59515.1, L40698.1 , U53501.1 , U41028.1, X07467.1 , Z1 1911.1, Z84471.1 , M99599.1, AB020872.1, M26655.1, AB013109.1, AL048716.3, AL038161.1 , AA447858.1, AW204529.1, AI557375.1, AA821444.1, AW583644.1, AW583578.1, AA385797.1, AA560410.1, AA870575.1, AA301506.1, AA471359.1, C83495.1, C82639.1, AA003181.1, AI525324.1, AA855729.1, AAl 63000.1 , AAl 87086.1, AW644280.1, AW765060.1, AI156263.1, AW646028.1 , AA137986.1 , AA638895.1, AI204083.1, AA545015.1, AA687160.1 , AW303995.1, AW009849.1, AI669342.1, AI636359.1, AI555299.1, AA248265.1, AI566150.1, AI027953.1, AA530808.1, AI669343.1, AW639641.1, AW276600.1, AI422353.1, AI616839.1, AW209495.1, AI679455.1, AI339009.1, AA873375.1, AA447703.1, AW764367.1, AW592606.1, AI104356.1, AW548701.1, AV180860.1, AV178105.1, AV177100.1, C54380.1, C36065.1, D34365.1, D33956.1, D33401.1, D27654.1, AW578603.1, AW229969.1, AW219265.1, AI921265.1, AI789557.1, AA894979.1, AA839723.1 , C79227.1 , AA451834.1 , AA451833.1 , AC022634.3, ACO 12206.3, AP002079.1 , AP002078.1 , ACO 18351.8, AC022295.7, AC062037.2, AC017100.3, AC010149.4, AC023940.2, AC022960.2, ACOl 1257.3, AC025764.3, AC027423.2, AC023592.2, AC013323.5, AC025712.2, AC025396.2, AC024945.2, AC015564.3, AC016105.3, AC022040.2, AC007603.1, AC015594.I, AL121996.5, AL109923.21, AL355352.3, AL132867.12, AL162471.1, AL139190.3, AL139418.1, AL049803.1, AP001990.1, APOO 1974.1, AC062004.2, AC068774.2, AC048384.2, AC022414.3, AC025431.3, AC062001.1, AC023131.4, AC024031.2, AC025003.2, AC009353.7, AC022997.3, AC018793.4, AC022529.3, AC021134.4, AC016035.3, AC019277.4, AC021225.3, ACOl 1855.2, AC012390.5, AC015675.1, AC012142.1, AC007905.1, AC005141.1, AL356355.2, AL353092.3, AL160275.2

SEQ ID NO: 452 ZH1268/T7

NM H4673.1, D14659.1, AC004492.I, AC009233.3, Z99133.1, AF178030.1, AC004838.2, AF048726.1, AL031430.1, AL135878.2, AJ243213.1, AL138651.1, AL033392.5, Z81364.1, AC006231.18, AF225898.1, AC005875.2, AC007421.12, AF028834.1, AL160191.2, Z99135.1, AJ232463.1, AJ232461.1, AJ232460.1, AJ232459.1, AJ232458.1, AJ232456.1, AJ232466.1, AJ232465.1, AJ232464.1, AJ232454.1, AJ232501.1, AJ232462.1, L31948.1, X68253.1, AC019209.3, AE003578.1 , AE003442.1 , AE003426.1 , AC006229.17, AC006472.1 , AC004802.1 , AL034556.3, AJ232455.1 , AP000477.2, AC009478.4, AC006332.3, AE003518.1, AC007151.2, AF030694.2, AC006150.2, AC005185.1, AF067217.1, AC004609.1, AC004075.1, AC003046.1, Z98551.1, AL133445.2, AL136296.2, Z95116.1, AL022159.1, U07978.1 , AI027953.1 , AI636359.1 , AI566150.1 , AW276600.1 , AI669342.1 , AI669343.1 , AI339009.1 , AA447703.1 , AA887811.1, AI147898.1, AI679455.1, AA836064.1, AA873375.1, AA534251.1, AI422353.1, AA745251.1, AA708596.1, AW130877.1, AW168287.1, AW303995.1, AI677854.1, AI420890.1, AA935810.1, AA938493.1, AA687160.1,

AA311297.1, T27967.1, AA301507.1, AA935814.1, N50202.1, AA683177.1, AA447858.1, N68048.1, AW009849.1, AW198055.1, AA181333.1, AI555299.1, AW592606.1, AI104356.1, AA530808.1, AA545015.1, AA137986.1, AW209495.1, AA893851.1, AI014068.1, AA067766.1, AI234816.1, AA638895.1, AA855729.1, AW123869.1, AI557375.1, AI204083.1, AW539200.1, AI102630.1, AV171265.1, AI556341.1, L26817.1, AA797564.1, AI843449.1, AV250940.1, AV359988.1, AV260102.1, AV257129.1, AV256840.1, AV253184.1, AV251229.1, AV249657.1,

AW124329.1, AV156582.1, AV172897.1, AV152635.1, AV151001.1, AV127867.1, AV122251.1, AVI 13481.1, . AV088039.1, AV087948.1, AV087721.1, AV060620.1, AV058322.1, AV056999.1, AV048088.2, AVO 15847.1, AA469099.1, D19285.1, Z36450.1, AV033019.1, AW204529.1, AV085824.1, AV127868.1, AV040300.2, AI150377.1, AW764367.1, AW646028.I, AV129270.1, AV120629.1, AV060547.1, AI317280.1, AA286921.1, AC022634.3, AC019351.3, AC025826.1, AL138828.4, AC055746.2, AC058784.2, AL355972.2, AL354717.1, AC068992.3, AC053499.2, AC027191.2, ACOl 1192.2, AC018608.4, AC023075.2, AL158149.3, AL138974.2, AL139234.1, AL138683.2, AC008049.22, AC069066.1, AC036179.2, AC027652.6, AC025758.2, AC008705.4, ACOl 1369.3, AC026388.6, AC027212.2, AC026523.2, AC024736.3, AC019106.2, AC022216.3, ACOl 1572.4, AC024451.2, AC021937.2, AC021998.3, AC023632.1, AL356219.1, AL160003.4, AL138920.2, AP000878.1, AC010176.7, AC026119.5, AC024902.5, AC034124.2, AC023666.3, AC027073.2, AC025380.2, AC004688.6, AC016998.1, AC008182.1, AL355877.3, AL356259.1, AL139329.8, AL354836.1, AL353789.1

SEQ ID NO:453 ZH1275/T3 NM_005271.1, X07769.1, X07674.1, M20867.1, M37154.1, J03248.1, AC006144.1, NM_012084.1, X66310.1, U08997.1, NM_008133.1, X57024.1, NM H2570.1, X14223.1, X14044.1, X66305.1, X66300.1, X66304.1, S60496.1, X66301.1, X53144.1, X53147.1, X66313.1, S60498.1, X66303.1, X66316.1, X53146.1, X66318.1, S60497.1, X66302.1, X53149.1, X53145.1, X53148.1, X66317.1, X66319.1, X66315.1, M17697.1, X66306.1, AE003745.1, Z29062.1, Y11314.1, U86783.1, AL009204.1, NM_015985.1, AE003679.1, AE003489.1 , NM_000277.1 , AFl 13708.1, AF074332.1, AC006065.3, U49897.1, AC004736.1, AL161757.2, AL162755.2, AL109865.36, S76376.1, L47726.1, K03020.1,

AB026191.1, W27073.1, AA227279.1, AA312202.1, AI789217.1, AW475321.1, AA014196.1, AA644784.1, AA383708.1, AA879600.1, AA008302.1, W41789.1, AA360821.1, W26604.1, W71024.1, AA017175.1, AA138870.1, AW320856.1, AA718335.1, AW045922.1, T19300.1, AA305029.1, AI640872.1, AI664278.1, AA072930.1, AW047896.1, AW380021.1, AA797796.1, AA185893.1, H31226.1, AI882241.1, AW818494.1, AW609909.1, AW818582.1, AW128806.1, AW280635.1, AW227033.1, F23009.1, W70382.1, W18826.1, W14066.1, AAl 87228.1, AI785754.1, AA186507.1,

AI385127.1, AA321600.1, AA511913.1, N57779.1, AU050259.1, AA887581.1, N91217.1, AI930482.1, AA409430.1, AI839659.1 , Al 193770.1 , AA025731.1, R72482.1 , N68424.1 , AI388049.1 , A A990898.1 , AA561182.1 , AI031170.1 , AA950162.1, AI658351.1, AI137421.1, AW280723.1, AA817402.1, AA698796.1, AA950738.1, AI882716.1, AI723596.1, AI477548.1 , H66387.1 , AA264699.1 , AW620147.1 , AI525665.1 , AA 160856.1 , H47916.1 , M78112.1 , AI545578.1 , AI056867.1, AA913604.1, AA682455.1, AA334497.1, AA203389.1, W01609.1, T97795.1, AL136982.1, AL133327.2, AC024946.4, AC022400.4, AC007929.7, AC008202.3, AC013137.I, AC023319.1, AC009274.5, AC026512.2, AC027088.2, AC024498.2, AC024161.1, AC026108.5, AC024091.4, AC022224.19, AC064820.3, AC067975.1, AC018613.3, AC019034.3, AC016486.4, AC004157.6, AC021685.3, AC016030.2, AC018534.3, AC023079.2, AC022845.2, AC018786.2, AC016670.3, AC012065.3, AC020525.1, AC009512.4, AC013214.1, AC013225.1, AC007571.4, AC005504.3, AC006104.1, AC004064.1, AL356099.1, AL161939.2, AL139005.1, AL136133.1, AP000974.2

SEQ ID NO:454 ZH1275/T7 NM_005271.1, X07769.1 , X07674.1 , M20867.1 , M37154.1 , X66312.1 , J03248.1 , AC006144.1 , X66310.1, U08997.1 , X67491.1, X66314.1 , AF086070.1, NM_012570.1, NM_008133.1 , X14223.1 , X14044.1, X57024.1, AL021396.5, AC004944.1, AE003805.1 , ACOl 1198.2, AE001699.1 , AC004335.1, X92729.1, AW008481.1, AW161914.1, AL121462.1 , AI796326.1, AI767015.1, AI719871.1 , AI688677.1, AI685203.1 , AI683603.1, AI609634.1, AW152299.1, AW778779.1, AI936502.1, AI924085.1, AI870436.1, AI220414.1, AIOl 7359.1 , AI860803.1, AI818481.1, AI373143.1, AI476186.1 , AI432139.1, AI434555.1, AI052741.1, AW779007.1, AI453009.1, AA705949.1, AA612700.1, AA576729.1, AI346963.1, AA719691.1, AW440634.1, AW299819.1, AI953347.1, AI669386.1, AW316988.1 , AA579763.1, AI479598.1 , AI041934.1 , AI865818.1, AA931220.1, AA639014.1, AW469758.1, AW105271.1, AI039164.1 , AI628503.1, AI547078.1, AI580269.1, AW131820.1 , AI955767.1, AI768285.1, N55432.1, AW662165.1, AI949911.1, AA968749.1, AI948510.1, H23769.1, AA205716.1, AA622009.1 , AI766220.1, AI628736.1 , AA961548.1, W32185.1, N58794.1, AA603980.1, AI200249.1, AI433759.1, AI799717.1, AA227280.1, AW206141.1, AA507097.1, AI871324.1, AI220678.1, D19635.1 , AA506817.1 , AI023057.1 , Al 167726.1 , AA984899.1 , H22628.1 , ALl 19832.1 , AI590208.1 , AA995612.1 , T29318.1 , H52944.1, AI220953.1, N62651.1, AI104010.1, AA932126.1, AW614089.1, AA352492.1, AI942453.1, H57922.1, AA541774.1, AI424426.1 , R54424.1 , W69491.1 , AA934829.1, AW779733.1, AI932689.1, AI582068.1 , AL136982.1, AL161935.5, APOOl 776.1 , ALl 63534.3, AC021193.3, AC023150.2, AC007117.1, AL137063.5, AL160158.2, AC025731.7, AC040988.2, AC063968.1, AC010902.3, AC022833.2, AC025924.2, AC021450.3, ACOl 1791.3, AC016365.4, AC016802.5, AC021761.3, AC023482.2, AC016991.2, AC020959.1 , AC020024.1 , AC018408.1, AL160162.4, AL136088.2, AL133269.8, AL355140.2, AL354743.1

SEQ ID NO:455 ZH1278 T3

NM_003011.1, U51924.1, X75091.1, M93651.1, D45198.1 , AC005666.1, Z95126.1, AC007649.12, AC008865.3, S68987.1, S68589.1, AL121985.13, AB015613.1, AB022692.1, AB022691.1, AF027174.1, AJ243486.1, AF102850.1, AF032922.1, AF039698.1 , AFl 03726.1, U48696.1, U34048.1, AF045432.1, AF033097.1, AJ243655.2, S78798.1, AJ249625.1, U66300.1, U39066.1 , AJ004935.1, U37573.1, AJ001103.1, Z97178.1, AJ010903.1, Y17148.1, U35663.1, U30169.1, Z49980.1, D61704.1, AC004106.1, ALl 18512.8, S64573.1, ACOl 1809.2, AF030515.1, AF061786.1,

AL121575.24, AC002091.1, AJ277276.1, AJ277275.1, AL109941.17, S64574.1, X99051.1, D13957.1, AW804718.1, AW297865.1, AI907472.1 , AI348548.1 , AW291539.1, AW819112.1, AW384700.1, AI656103.1, T19570.1, AI348464.1, AW580047.1, AA738062.1, AW463846.1, AW390103.1, AW373693.1, AL022685.1 , AI316314.1, AA611351.1, AA549598.1, AA414765.1, AA123463.1, AA796821.1, AA667063.1, AAl 18033.1, C79263.1, AA607821.1, AW373676.1 , AW681843.1, AJ398907.1, AA714153.1, AA206519.1, AW390843.1, AA069741.1, AW842631.1, AV097455.1,

AI267315.1, AA329702.1, AA313621.1, AA233558.1, D54409.1, AA409879.1, H34224.1, AW375988.1, AW536757.1, AA099025.1, AU045232.1 , AW537027.1, AW375987.1, AW239416.1, AI768142.1, AA377175.1, AA356749.1, AA318099.1, AA314914.1, AA296390.1 , AA206939.1, AA074744.1, AA069861.1, AI981321.1, AW390108.1, AA461024.1, AA474415.1, AW682597. , AW209981.1, ALl 18403.1, C89073.1, AA624202.1, AA474356.1, AA170936.1 , AA103478.1, D28721.1, D21513.1, AW629348.1, AI101820.1, AL024232.1, AI467387.1, AA341055.1, AA122619.1, AA793865.1, AW773136.1, AA179445.1, AW390844.1, AA606606.1, AW644081.1, AW638871.1, AW634071.1, AW158383.1, C89511.1, AA377176.1, U47704.1, AJ396687.1, AI815353.1, AW547461.1, AI815356.1, AA549660.1, AW682308.1, AW543995.1, AW537538.1, AI477163.1, AI477134.1, AC067721.3, AC024160.2, AC016607.5, AC008879.3, AC008818.4, AC023066.2, AL138838.2, AC036148.2, AC027472.2, AC068438.1, AC008905.5, AC018394.2, AL163195.2, AC017015.3, AC027082.2, AP000831.1, AP000713.1, AC025974.2, AC018915.3, APOOl 148.1, AC024503.2, AL161451.4, ACOl 1076.2, AC068294.2, AC015767.1, AC027457.2, AC044882.2, AL159155.2, AC021505.I , AC025391.3, AC044900.2, AC058821.2, AC026506.2, AC021248.3, AL121938.4, AL136359.4, AL355150.3, AL162371.5, AL136312.1 SEQ ID NO:456 ZH1278 T7

NM_003011.1, M93651.1, D45198.1, AC005666.1, X75091.1, Z95126.1, AC008865.3, U51924.1, AL121985.13, AC007649.12, AC004106.1 , Y16709.1, Y16700.1, Y16698.1, AL049776.3, AC016940.7, AC016939.8, S68987.1, S68589.1 , U66083.1, U69568.1, AC002385.1, AC004816.1, AC002126.1, AC000055.1, AC007277.2, AL163491.1 , Z86062.1 , AB022692.1, AW868532.1, AW780330.1, AW591220.1 , AW513750.1, AW293933.1, AW245056.1, AW244076.1, AW168969.1, AW090022.1, AW083629.1, AW044189.1 , AW007774.1, AI968676.1, AI950006.1, AI936602.1, AI924906.1, AL037448.1, AI753576.1, AI654239.1, AI580115.1 , AI564211.1, AI524784.1, AI355458.1, AI325543.1 , AI31 1829.1 , AI309210.1 , AI276264.1 , AI272933.1 , AI253373.1 , AI208354.1 , AH 61319.1 , Al 160942.1 , AI143855.1, AI123422.1, AI056850.1, AI032559.1, AI024969.1 , AA989168.1, AA989103.1, AA953828.1, AA781061.1, AA721786.1, AA716380.1 , AA716371.1, AA694154.1 , AA669764.1, AA644321.1, AA641186.1, AA634951.1, AA634910.1, AA634838.1, AA630300.1, AA583450.1, AA577550.1, AA479216.1 , AA450173.1, AA450108.1, AA371437.1, AA314939.1, AA309906.1, AA309718.1 , AA223348.1, AA206857.1, AA179301.1, AA160127.1 , AA062923.1 , W26593.1, N67146.1, N41803.1, N32850.1, D29035.1, AA369866.1 , AA074909.1, AW732805.1, AL037182.3, AA917780.1, AA669856.1, AA478675.1, AA848156.1, AA363086.1, AA206002.1, AA063530.1, AW801878.1, AW078466.1, AW303316.1, AI092597.1, AA579413.1 , AA668238.1, AA578980.1, AA564790.1, AA630703.1 , AA482218.1 , AA516095.1 , AW674250.1 , AA748113.1 , AA737104.1 , AI419588.1 , AA352137.1 , T94763.1 , AA714153.1, ACOl 1076.2, AC023066.2, AC015767.1, AC067721.3, AC024160.2, AC008905.5, AC008401.3, AC027457.2, AC027082.2, AC036148.2, AC027472.2, AC024503.2, AL163195.2, AC016607.5, AC008879.3, AC008818.4, AL138838.2, AC010951.4, AC018372.4, AC018394.2, AC017015.3, AP000831.1, AC021355.3, AP000713.1, AL161451.4, AL121594.2, AC016150.5, AC068294.2, AC021853.3, AC015936.3, AC025624.3, AC068198.6, AC023430.9, AC008558.4, AC008746.5, AC025802.2, AC005507.6, AC01671 1.3, AC013534.1, AC005504.3, AC004710.3, AL162271.2 SEQ ID NO:457 ZH1283/T3

Z49250.1, AF040964.1, ALl 10292.4, NM_015821.1, AC016752.2, AC008175.2, AF176523.1, Z81109.1, AC009303.2, AE003567.1, AE003419.1, AC004615.1, AC007202.2, U66059.1, AL163256.2, AC000098.1, AL161541.2, Z70204.1, AL021920.1, Z97338.2, AL 109630.1 , X04934.1, AP00171 1.1, X61440.1, X58329.1, X74843.1, L33104.1, AP000212.1, AP000030.1, AP000251.1, AP000134.1, X94621.1, AW554727.1, AV336063.1, AV252097.1, AI747169.1, AI064780.1, C79851.1, AW841034.1, AW174525.1, AI866180.1 , AI289862.1, W13501.1, R73747.1, AL158068.4, AC027512.2, ACOl 1 156.3, AC015497.3, AL353695.1 , AC021861.3, AC012404.4, AC009682.3, AC026702.3, AC007322.3, AC055867.1, AC026077.3, AC022973.2, AC008061.1, AC007965.2, AC007315.2, AL354884.2, AL353668.2, AC020609.4, AC026116.7, AC064796.2, AC069023.1, AC027235.2, AC027313.2, AC022446.3, ACOl 1370.2, AC008561.3, AC024230.3, AC027386.2, AC044784.4, AC016309.6, AC026865.3, AC026277.3, AC010973.3, AC02231 1.4, AC026276.2, AC027059.2, AC026070.2, AC018966.3, AC016412.3, AC023659.2, AC025523.2, AC024956.3, AC013652.3, AC0231 15.3, AC022672.3, AC016483.6, AC016018.7, AC022841.2, AC016401.3, AC010734.3, AC021338.3, AC016674.3, AC014321.1, ACO 14906.1 , ACO 16354.1, AC015894.2, AC009703.2, AC008084.2, AL356369.1, AL135924.10, AL139238.2, AP001257.1

SEQ ID NO: 458

ZH1283/T7

AF040964.1, Z49250.1 , Z83850.1, AEOOl 145.1, AF191070.1, AC009248.6, AF016450.2, U61946.1, U49830.1,

NM_014386.1, AF182034.1, AC020647.9, AFl 18125.1, AL034371.16, AL033127.1, U19575.1, AC007232.5, AC008269.3, AF 130342.1 , AL035464.20, AL080238.9, AL034427.1 , AP000561.1, AI808442.1, AA664012.1, AI628516.1, AA630380.1 , AW043655.1 , R69790.1 , R69789.1 , AW513701.1 , H56500.1 , H56688.1 , Z21088.1 , AA652148.1 , AW610692.1, AW553895.1, AI451124.1, C80481.1, AI462312.1, C85371.1, AI591821.1, H61855.1, AI604189.1, AA177891.1, AI449315.1 , AW554802.1, U83055.1, AV314215.1, AV207115.1 , AV295151.1, AV368467.1, AV214236.1, AV295152.1, AV257539.1, AV295169.1, AV367514.1, D29398.1, AAl 83653.1, AW681938.1, AW046876.1 , AV145607.1, AA210324.1, AA174896.1, AW079106.1, AU012850.1, AU012683.1, AU012324.I , AU006614.1, AA332492.1, AW414996.1, AW339249.1 , AW335085.1, AW158276.1, AL037685.2, AI807819.1, AI641202.1, AI544578.1, AI477034.1, AI4431 14.1, AI440704.1 , AA940518.1, D72454.1, D27504.1, AL158068.4, AC019140.3, AC040892.1, ACOl 1566.3, AC016963.7, AC010302.3, AC021353.3, AC013807.3, AC027533.1, AC012056.3, AC026215.1, AL133326.8, AP001257.1, APOOl 181.1, AP000726.2, AC036220.2, AC025435.3, AC010314.4, AC034172.2, AC025660.2, AC009957.5, AL139134.4, AL353765.3, AL353739.2

SEQ ID NO: 459

ZH1285/T3

NM_016520.1, AF218421.1, AF151054.1, AL137549.1, NM_016482.1, AL122003.17, AE003472.1, AC005557.1 , U89363.1, AFl 19871.1, NM_014008.1, AF235097.1 , AC004843.1, AF130342.1, AF005370.1, AL031984.13, AJ005890.1, AC009303.2, AC004136.2, AC010072.5, AC002386.1, NM_003834.1, NM_001761.1, AC007240.2, AF152489.1, AC006257.1, AC005938.1, AF035154.1, AF035153.1, AC005752.1, AC005214.1, AC002398.1, AL163290.2, AL163264.2, U17105.1, AB016929.1, AL161559.2, AL161542.2, AL033510.1, AL133247.1, AL137579.1, AL035394.1, Z97339.2, Y14523.1, X15485.1, Z31356.1 , X04333.1, AP001745.1, AP001719.1, AP001620.1, Z36714.1 , AP000166.1, AP000051.1, AB018114.1, AP000317.1, APOOOl 19.1, AP000355.1. M21356.1, M74420.1, AB007976.1, AC016109.3, AC027008.2, AL158207.3, AC025982.2, AC010038.3, AC018306.1, AC021040.3, AC025346.1 , AC068892.1, AC010543.4, AC009128.5, AC027761.2, AC041028.1, AC021615.4, AC018614.3, AC009335.2, AC023278.2, AC010910.6, AC018377.4, AC022983.2, AC023266.2, AL138752.3, AL354885.1, AL157717.2, AL161665.1, AC055765.6, AC025569.5, AC024523.2, AC026799.2, AC026736.3, AC010249.5, AC008641.4, AC008432.3, AC009274.5, AC027450.2, AC027256.2, AC009677.3, AC060871.1 , AC052251.1, AC026621.2, AC044807.1 , AC026585.2, AC011924.4, AC019004.3, AC008707.3, AC021818.3, AC027718.1 , AC022036.3, AC022298.8, AC024535.2, AC022909.4, AC021404.3, AC021260.4, AC024020.2, AC024342.2, AC008579.2, AC023300.3, ACOl 1725.3, AC022315.5, AC010687.2, AC024161.1, AC021350.2, AC009881.3, AC010953.1 , AL354883.4, AL356139.2, AL162579.4, AL355363.2, AL353772.1, AL162390.3, AL161740.4, AP001586.1, AW161972.1, W26201.1, AA132627.1, AA317976.1, AU035568.1, AW431809.1 , AW446432.1 , AI767692.1, AA122999.1, AW404731.1, C84411.1, AA001736.1, AW867890.1, AA672516.1, AA067123.1, AH 17776.1, AI527151.1, AI120866.1, AI651600.1, AI514054.1, AA568390.1, A W342787.1, AA317456.1 , W69638.1, AW058741.1, AI158344.1, AA897584.1, W10607.1, AW786051.1, AI082881.1, D47367.1, AW859546.1, AW498709.1, AW233754.1, AV272856.1, AA944898.1, AA458784.1, T08446.1 SEQ ID NO: 460 ZH1285/T7

AF040964.1, Z49250.1, Z83850.1, AEOOl 145.1, AF191070.1, AC009248.6, AF016450.2, U49830.1, NM_014386.1, AF182034.1, AC024869.1, AC020647.9, AFl 18125.1, AC007232.5, AF130342.1, AL035464.20, AL080238.9, AL034427.1, AP000561.1, AI808442.1, AA664012.1, AI628516.1, AA630380.1, AW043655.1, R69790.1, AW513701.1, H56500.1, R69789.1, H56688.1 , Z21088.1, AA652148.1 , AW610692.1, AW553895.1 , AI451 124.1, C80481.1, AI462312.1, C85371.1, AI591821.1, AI604189.1, AA177891.1, AI449315.1, AW554802.1, U83055.1, AV314215.1, H61855.1, AV207115.1, AV295151.1, AV368467.1, AV214236.1, AV295152.1, AV257539.1, AV295169.I , AV367514.1, D29398.1, AA183653.1, AW681938.1, AW046876.1, AV145607.1, AA210324.1, AA174896.1, AA332492.1, AW414996.1 , AW339249.1 , AW335085.1, AW158276.1, AV385524.1, AL037685.2, AV183523.1, AV178057.1, AI807819.1, AI696097.1, AI626600.1, AI544578.1, AI477034.1, AA980276.1, AA928231.1, C65891.1, C61074.1, C53590.1, AA279783.1, C10643.1, AL158068.4, AC026977.2, AC019140.3, AC040892.1 , AL133373.1, AC010302.3, AC009795.3, AC013807.3, AC027533.1, AC012056.3, AC006906.2, AL133326.8, Z82209.1, AP001257.1, APOOl 181.1, AP000726.2, AC036220.2, AC025435.3, AC010314.4, AC009436.2, AC034172.2, AC025660.2, AC012528.2, AC009957.5, AL353739.2

SEQ ID NO: 461

ZH1286/T3

ALl 17590.1, AC007245.3, AC003683.1, AL355072.2, AE003652.1 , AC005120.1, AC006214.1, AL161550.2, AL021687.1, AC007063.5, AC004535.1, AC013453.1, AC004752.1, AL049777.5, AL096862.18, AF000265.1,

AL132764.1, Z70205.1, AP000139.1 , AP000226.1, AP000087.1, D85389.1, AC005970.2, AC021640.5, AC006287.1, AE001368.1, AC004629.1, AL163232.2, AL049860.8, AL031177.1, AL031733.3, AL031600.4, Z82195.1, AL031653.5, AP001687.1, AA 175375.1 , AI740728.1, AA332493.1, AI074062.1, AI580915.1, AI087846.1, AI810796.1, AW874606.1, AI016838.1, AA470819.1, W85623.1, W85600.1, AI449083.1, AI549242.1, AI845400.1, AV015395.1, AV375672.1, AV327111.1, AV354227.1, AI383006.1, AV300969.1, AV253424.1, AI604667.1, AA771574.1 , AV376539.1,

AW332467.1, AW642408.1, AW636829.1 , AW635398.1, AW634742.1, AW634652.1, AI467036.1, AA285835.1 , ALl 35649.1 , AV377755.1, AI915385.1, AV064014.1 , AV062554.1, AA808321.1, AA525659.1, AA458724.1, AA232022.1, AA118229.1, R12836.1, T37449.1, AC034212.3, AC022121.3, AC008522.4, AC008531.2, ACOl 1129.3, AC025069.3, AC021824.2, AC023528.3, AC020916.4, AC023808.3, AC004689.5, AL354852.3, AC036175.2, AC019106.2, AC019274.3, AC015595.3, AC006280.6, AC022947.2, AC023567.2, AC022977.1, AL137780.2, AL135926.4, AC048385.2, AC016650.4, AC032009.2, AC005077.2, AC027637.2, AC015497.3, AC021515.3, AC025385.2, AC019328.4, AC021562.3, AL354805.2, AL139284.3, AL355811.2, AL031749.7

SEQ ID NO: 462 ZH1286/T7

AC007190.4, AC005698.1, AL163244.2, AP001699.1, AP001604.1, X89454.1, X95537.1, X9911 1.1, AF241733.1, AE003837.1, NMJH0743.1, AC004240.1 , AC005483.1, AC005017.1, AC010675.4, AC012561.2, AC005430.1 , AF022978.1, AC005209.1, AF027390.1, AC002368.1 , AL121841.5, AL133239.2, AL031856.1, Z81519.1, X65721.1, X60184.1, D26185.1, L16865.1, AB015478.1, M24843.1, Z99124.1 , N78373.1, AA046865.1, AI074753.1, W23958.1, W58729.1, AI570623.1, AA662071.1, AI283307.1 , N24666.1, AI042238.1, AI871705.1, AI308931.1, N29591.1, N35457.1, AA121714.1, N35732.1, AA662105.1, AI077613.1 , C02199.1, N94508.1, AW193423.1, AW137463.1, AW087689.1 , AI932544.1 , AI023068.1 , AIO 16553.1 , AA668903.1 , AA603930.1 , AA569968.1 , W81286.1 , W45153.1, AI077894.1 , AW316941.1 , AA046618.1 , AI468297.1 , AI468375.1 , AI952677.1 , AA534051.1, AV339939.1 , Al 136305.1 , AA801116.1, AA801115.1, AW488840.1, AV326475.1, AV307940.1, W80228.1, AI407687.1, AW392276.1, AV313326.1, AV338001.1, AV327247.1, AV220383.1, Z98519.1, AV327255.1, AV235696.1, W45104.1, AV353938.1, AV221367.1 , AA472496.1, AV174463.1, AV344161.1, AV340653.1, AV229817.1, AI615511.1, AV343186.1, AV341443.1, AA561896.1, AA240049.1, AI099985.1, W43492.1 , AV008073.1, AC034212.3, AC022121.3, AC008522.4, AC008531.2, AC009423.2, AL157399.2, AC018905.3, AC025281.2, AC009024.5, AC010086.3, AC034141.2, AC024681.2, AC024087.3, AC018732.5, AC022568.3, AC023249.1, AC022030.1, AC021343.1, AC009454.1, APOOl 120.1, AC015547.5, AC063918.4, AC022275.9, AC010275.4, AC009579.3, AC027256.2, AC016073.2, AC024714.4, AC009504.3, AC018970.4, AC008709.2, AC019358.3, AC018541.3, AC013744.3, AC022913.3, AC022695.3, AC015956.3, AC020706.3, AC021955.2, AC022694.2, AC019068.3, AC020392.1, AC005415.6, AC007139.1, AL157413.7, AL138710.3, AL355887.1, AL356032.1 , ALl 33474.8, AL121890.19, AL021152.1, AL157696.2, AP001655.1, AP001654.1 , AP001381.1, AP000902.2

SEQ ID NO: 463

ZH1288/T3

X68060.1, M27504.1, X86455.1, X86456.1 , NM_009409.1, D38046.1, AB007446.1, AF087149.1, Z15115.1, AB007445.2,

AB009387.1, Z19552.1, Z46372.1, L04607.1, Y16594.1, Y16595.1, NM_011623.1, D12513.1, NM_001067.1, J04088.1, AF071740.1, AJ011745.1, AJ011746.1, AF013277.1, AF087148.1, Z49069.1, M13814.1, Z94277.1, Y14559.1, AJ238786.1 , Z71364.1, X89016.1, L21015.1 , D82024.1 , NC_001224.1, AC004622.1 , AL135749.2, AJ011856.1, V00700.1, L36900.1, K00384.1 , J01462.1, K01981.1, M35613.1 , NMJH4920.1, AF106577.2, AC005413.1, AL136296.2, Z81521.1, Z81 1 17.1, Z30974.1, AB023153.1 , X79345.1 , AC008166.2, AF016677.1, AC007685.2, AF125956.1, AC004210.1, U67558.1, AL035078.32, AL134583.1, AW502948.1, D56256.1, AI649350.1 , AL041840.1, AI648781.1, AW369469.1, AA517639.1, AL040877.1, AI959436.1, AI648275.1, AL042407.1, AA080801.1, AW719663.1, AI806632.1, AA872214.1, AA847887.1, AA766751.1 , AW683426.1 , AW257697.1 , AI635985.1, AI619958.1, AI455477.1, AA321068.1 , AA309468.1, AC012037.8, AC022906.1, AC018629.3, AC015851.3, AC069032.1 , Z99713.1, AL162716.4, AC025833.2, ACOl 1754.3, AC010903.3, AC069243.1, AC060776.2, AC008497.4, AC010756.2, AC021580.3, AC020692.1, AC016863.2, AL133461.2, AC025371.2, AC013372.5, AL353627.1, AL049183.5, AC026328.3, AC046164.2, AC062039.1, AC007366.3, AC022526.4, AC025800.2, AC013364.7, AC012118.2, AC023349.2, AC023287.3, AC006844.1, ALl 17381.13, AL136038.1

SEQ ID NO: 464 ZH1288/T7

AF087160.1, Z15115.1, U54831.1, X68060.1, X86456.1, X86455.1, NM_009409.1, D38046.1, AJ011732.1 , AJOl 1731.1, AB007446.1, AF087159.1, AL133396.1, AJOl 1730.1, AF043705.1, AF025469.1, AE003821.1, AC004808.1, AC002074.1, AC006314.2, AC005852.1, AL163243.2, AL132847.1, Z73423.1, AL023835.1, X72263.1, AP001698.1, AP001603.1, AP001602.1, AI591391.1, AI261517.1, AI338649.1 , AW664997.1, AW515712.1, AW467306.1, AW467294.1, AW418947.1, AW192951.1, AWl 83653.1, AW006531.1, AI989480.1, AI69601 1.1, AI694881.1 , AI679913.1, AI679406.1, AI523670.1, AI478835.1, AI373284.1, AI348003.1, AI339647.1, AI335268.1, AI318389.1, AI304812.1, AI278060.1, AI27201 1.1, AI039289.1, AA953079.1 , AA904801.1, AA779797.1, AA721732.1, AA424359.1 , AAl 15017.1, W93707.1, W46532.1, AW269912.1, AI917755.1, AI766280.1, AI656688.1, AI560886.1, AI476680.1, AI144514.1, AI089698.1, AA992925.1, AA953420.1, AA620947.1, AA555180.1, AW291834.1 , AW515720.1, AW078947.1, AI304903.1, AWl 18156.1 , AI631155.1, AI309222.1 , AI050083.1, AA708813.1, AA055323.1, AA973445.1, AA922984.1, H97974.1, AI694605.1, AA424448.1 , AW274857.1, AI831468.1, AA031925.1, AW272870.1 , AI694343.1, AI280170.1, AI039017.1 , AA826849.1, AA621113.1, AA199624.1, AI097265.1, AA031996.1, W46206.1, N63584.1, AI637932.1, W57560.1, AW188889.1, AI758405.1, W93759.1, W32771.1, H89909.1, AI659327.1, W26487.1, AW244066.1, AAl 15016.1, T29334.1, AA807183.1, W57766.1, AW049818.1, D59157.1, AW523616.1, AI935392.1, AI059170.1, AW141413.1, AA259497.1, AA238444.1, AH 77826.1, AA946055.1, AC012037.8, AC009729.4, AC025004.2, AC016714.2, AC021540.2, AC009490.5, AL355392.2, AL109808.2, AC068479.1, AC018624.3, AC017068.3, AC021436.3, AC006721.1, AC026405.2, AC010585.4, AC031978.2, AC027285.1, AC025054.2, AC012432.4, AC023873.2, AC009425.2, AC007356.7, AC012229.2, AC017352.1, AC015609.2, AL355307.2, AL354732.4, AL138875.3, AL355304.3, AL355527.1, Z93243.1

SEQ ID NO: 465

ZH1308/T3

ALl 17590.1, AC007245.3, AC003683.1, AL355072.2, AL021687.1, AC007063.5, AC021640.5, AC003082.1,

AC004535.1, AL049777.5, AL096862.18, AL132764.1, AP000139.1, AP000226.1 , AP000087.1 , D85389.1, ACOl 1493.4, AC005662.2, AC002354.2, AE003163.1, AC007536.9, AF100956.1, AC004629.1, AL163232.2, AL031177.1,

AL031733.3, AL031653.5, AP001687.1, M77182.1, M75889.1, AI740728.1 , AA175375.1, AA332493.1, AW874606.1, AI810796.1, AI087846.1 , AI074062.1, AI016838.1, AA470819.1 , AI580915.1, AI549242.1, AI383006.1, AI449083.1, AI845400.1, W85623.1, W85600.1, AV375672.1, AV015395.1, AV327111.1, AI741614.1, AV300969.1, AV354227.1, AV376539.1, AV283831.1, AV253424.1, AW122375.1, AI604667.1, AA771574.1 , AW642408.1, AW636829.1, AW635398.1, AW634742.1, AW634652.1, AW332467.1, AI467036.1, AA285835.1, AL135649.1, AV377755.1, AI915385.1, AV173187.1, AV064014.1, AV062554.1, AI347646.1, AA808321.1 , AA525659.1, AA458724.1, AA232022.1, AAl 18229.1, R12836.1, T37449.1, AC034212.3, AC022121.3, AC008522.4, AC008531.2, AC021824.2, AC023528.3, AC040943.2, AC036206.2, AC020916.4, AC023808.3, ACOl 1129.3, AC025449.3, AC019274.3, AC015595.3, AC006280.6, AC022977.1, AC013702.2, AL137780.2, AC048385.2, AC032009.2, AC021515.3, AC026097.1, AC021562.3, AL354805.2, AL35581 1.2, AL035477.5, AL034557.7, AL031749.7

SEQ ID NO:466

ZH1308/T7

AC005884.1, AC006395.1, AC007190.4, AC005698.1, AC005345.1, AE000323.1, AL163244.2, AC002066.1, AJ133269.1, D90866.1, D90865.1, AP001699.1, AP001604.1, X89454.1, X95537.1, X99111.1, AF241733.1, AE003837.1, NM_010743.1, AC004240.1, AC005483.1, AC005017.1, AC004381.1 , AC007106.6, AC005430.1, AF051676.1 , AC005209.1, AF027390.1, AC004399.1 , AC002368.1, AL121841.5, AL133239.2, Z81519.1, X65721.1, X60184.1, X68090.1, AB015478.1 , M24843.1, AI074753.1, N78373.1, AA046865.1, W23958.1, AI077613.1, N94508.1, W58729.1, AI570623.1, AA662071.1, AI283307.1, N24666.1, AA121714.1, AI023068.1, N35457.1 , AI042238.1, N35732.1, AA662105.1 , AI871705.1, AI308931.1, N29591.1, C02199.1, AW193423.1 , AW137463.1, AW087689.1, AA603930.1, W45153.1, AI016553.1, AA668903.1, AA569968.1, W81286.1, AI932544.1, AI077894.1, AW316941.1, AA046618.1 , AI468297.1, AI468375.1, AA534051.1, AI952677.1, W45104.1, AI136305.1, AA801 116.1, AA801115.1 , AW488840.1, AW392276.1, AV339939.1, AV326475.1, AV307940.1, W80228.1, AV313326.1, AI407687.1, AV338001.1, Z98519.1, AV220383.1, AV327247.1, AV235696.1 , AV327255.1, AV353938.1, AV221367.1, AA472496.1, AV344161.1, AV174463.1, AV340653.1, AV229817.1, AI615511.1, AV343186.1, AV341443.1, AA561896.1, AA240049.1,

AA718024.1, AI099985.1, W43492.1 , AI927150.1, AC034212.3, AC022121.3, AC008522.4, AC008531.2, AC008245.2, AC009423.2, AC018905.3, AC025281.2, AC018640.1, AC010536.3, AC009024.5, AC010086.3, AC009690.3, AC034141.2, AC008706.2, AC024681.2, AC024087.3, AC018732.5, AC022568.3, AC023249.1, AC022030.1, AC021343.1, AC009454.1, APOOl 120.1, AC015547.5, AC055864.2, AC02741 1.2, AC010275.4, AC008763.4, AC068171.1, AC009579.3, AC013307.4, AC016073.2, AC024714.4, AF235106.1, AC008709.2, AC025966.2, AC013744.3, AC022913.3, AC022695.3, AC024133.2, AC017058.4, AC022694.2, AC012168.6, AC019068.3, AC012448.3, AC020392.1, AC005415.6, AL356274.2, AL162231.4, AL355887.1, AL356032.1, AL133474.8, AL121890.19. AL021152.1 , AL157696.2

SEQ ID NO: 467

ZH1310/T3

NM_014684.1, AB002371.1, AF176816.1, U28738.1, AC004492.1, ALl 17667.2, AC020728.4, AC007738.2, AC007746.3,

AC004082.1, AL163269.2, AL163217.2, AF002196.1 , AC000114.1, Z80223.1, AL023835.1, Z78013.1, Z95116.1 , AP001724.1, AP001672.1, AJ229041.1, AA731488.1, AW510899.1, AI425080.1, AA805758.1, AA740870.1, AW379875.1, AI137203.1, AA514569.1, AV426088.1, AV425335.1, AV417571.1, AV417509.1, AV410321.1, AV408706.1, AV407889.1, AV429307.1, AV203109.1, AV196140.1, AI702988.1, AU031977.1, C71395.1, C63479.1, AA101793.1, T39979.1 , D37593.1, D34838.1, AV421197.1, AW612721.1, AW601552.1, AW295899.1, AV316295.1, AV217403.1, AW080057.1, AI912653.1, AV200025.1, AV184265.1, AV183798.1, AV182538.1, AV177977.1, AV177844.1, AV123582.1, AV098669.1, AI739163.1, AI701705.1, AI688792.1, F19452.2, AI534462.1, AI395032.1, AA999602.1, AA807666.1, AA658626.1, C64557.1, C53782.1, C53639.1, C52086.1, C51614.1, AA513926.1, AA341985.1 , AA284009.1, T61753.1, D32789.1, T01 101.1, AC044815.2, AC026587.2, AL355598.3, AC016598.3, AC026231.1, AF165146.1 , AL137879.3, AC026791.2, AC008952.4, AC009333.8, AC009054.4, AC010726.3, AC026932.2, AC027003.2, AC009633.4, AC020739.4, AC022812.2, AC012481.2, AL157774.5, Z95311.10, AP001498.1, Z83124.1

SEQ ID NO: 468

ZH1310/T7

NM_014684.1, AB002371.1, AL049382.1, AF176816.1, AC005561.2, AC021198.2, U41543.1, AC004059.2, AF095703.1, AL035705.22, AF000198.1, AC006807.1, AF187015.1, AC005483.1, AC009743.1, AC006253.4, AF092091.1,

AF020503.1, U43574.1, ALl 32877.2, AK000060.1, AC024827.1, ACOl 1809.2, AC016827.5, AC004861.1, AF122982.1, AC006265.1, AL161562.2, AL035451.5, AP000017.2, X95541.1, AI307250.1, AI271439.1, AI650441.1, AI017475.1, AI672237.1 , AI251828.1 , AI350623.1 , A W513806.1 , AI374969.1 , AA483351.1, AI334985.1 , Al 146704.1 , AA629033.1 , AI000570.1 , AW594414.1 , AI491723.1, D45489.1 , AL049146.1, AI143491.1 , AW020704.1, AI208598.1, AW795365.1, AA779644.1, AI256761.1 , Tl 8542.1 , AW485825.1, AW429714.1, AV279572.1, AV276939.1 , AI585504.1, AW656607.1 , AA138162.1, AJ397541.1, AI799424.1, AI793220.1 , AI793043.1, AI702885.1 , AI262125.1, AA972361.1, AW664166.1, AW418951.1, AW298528.1 , AW129197.1, AW070252.1, AI984802.1, AI669330.1, AA970231.1, AA912726.1, AA329579.1, D34789.1, AW783019.1, AW765809.1, AW684085.1, AW067635.1, AU058169.1, AI563818.1, AI098926.1, C66867.1, AA329912.1 , AC024063.1, AC008413.5, AC010220.3, AC026739.3, AC008375.6, AC008733.4, AC009194.2, AC0171 10.3, AC025244.2, AC021524.4, AC006782.2, AC000016.1, AC016969.11, AC012514.8, AC022250.2, AC008558.4, AC018623.4, AC024005.2, AF130866.1 , AL158157.2, AL138705.3

SEQ ID NO: 469 ZH13310/T3 NM_016310.1, AF051316.1, AF126531.1, Z69719.1 , AE003791.1, AF165923.1, M97636.1, AF132734.1, AC022355.3,

AF002223.1, NC .001142.1 , AE003708.1, AE003632.1, AC002045.1, AC002039.1, U91326.1, AC002544.1, AF095725.1, AC004263.1, U78308.1 , U76377.1, U53580.1 , M94081.1, AE000662.1 , AL121866.13, AL161548.2, AL096711.9, AL049828.3, Z29560.1, AL022326.1, AL021408.1, AL021713.1, Z49311.1, Z48229.1, AW167513.1, AW138186.1, AI760367.1, AA263042.1 , AI224102.1, AA314434.1, AI094028.1, AI074736.1, AI220149.1, AI313394.1, AI082184.1, AI268800.1, AA476966.1, AA126951.1, AW672863.1, C00817.1, AW385705.1, AI369802.1, AA773182.1 , AW275005.1, AA352782.1, AA827399.1, AA669773.1, AI241541.1 , AI569242.1, AI913788.1, AA912503.1, AW426495.1, AW381929.1, AW429636.1, AW426017.1, AW785359.1, AW418739.1, AW793665.1, AA271604.1, W98752.1, AA009299.1. W59077.1. AI286727.1, AAl 18991.1, AI122511.1, W64539.1 , AA822533.1, AA199237.1, AA051263.1, AA537627.1 , AA590075.1 , AAl 98139.1 , AW488481.1, AA604039.1 , AI868548.1 , AA268809.1 , H31197.1 , AI368581.1 , AA837254.1, AW484117.1, AW484121.1, AI858883.1, AW675452.1, AA691124.1, AW003500.1, AW528612.1, AA120383.1, AI415794.1, AW637653.1, AU014893.1, AA606218.1, AW452227.1, AA413355.1, AW739254.1, AA736083.1, AA696686.1 , AW689226.1, AW346361.1 , AW302482.1, AW273452.1, AW172797.1, AI953902.1, AI814500.1, AI742562.1, AI674413.1 , AI537928.1, AA948029.1, AA752389.1, AA582962.1, AA558493.1, AA555398.1, AA550767.1, AA542978.1, AA534864.1, AA533877.1, AA532234.1 , AA532318.1, H07126.1, T67650.1, AC010552.3, AC007604.1, AP001005.1, AC020707.2, AC018350.2, AC015996.2, AC009218.6, AC016019.3, AC020202.1, AC007837.3, AL136096.6, AL138723.4, AP001008.2, AC023794.9, AC023320.2, AL136967.2, AC026709.2, AC010638.4, AC064794.1, AC025228.2, AC023388.2, AC012645.4, AC009152.5, AC008956.5, ACOl 1967.3, AC016002.5, AC044828.1, AC016516.3, AC023068.3, ACOl 1999.3, AC014357.1, AC005136.1, AL162731.2 SEQ ID NO: 470 ZH13301/T7

AF126531.1, Z69719.1, NM_016310.1, AF051316.1, AC067968.1, AC005034.1, AE002102.1, AL109943.18, Z98946.15, Z68887.1, Z501 12.1, D88193.1, M97636.1, AE002705.1, AC008015.5, AC024874.1, AC004011.1 , ACOl 8363.6, AC005018.2, U80837.1, AF061282.1 , AL021492.1, Z82270.1 , AB018007.1, AF132287.1, AE003632.1, AC003075.1, AC005158.2, AL163279.2, AL163278.2, AL034556.3, AL161537.2, U39367.1, U30841.1, D31785.1, AL021531.1, AW167513.1, AW138186.1, AI760367.1 , AI224102.1, AI094028.1 , AI074736.1, AI369802.1, AI220149.1, AI313394.1, AI082184.1, AI569242.1, A1241541.1 , AA126951.1, AA912503.1, AI913788.1, AW275005.1 , AA773182.1, AW418739.1 , AA263042.1, AA827399.1, AA669773.1, AI268800.1, AI868548.1, AA314434.1, AI368581.1, AW385705.1, AA837254.1, C00817.1 , AA476966.1, AA604039.1, AW675452.1, AW672863.1, AW426495.1 , AW426017.1, AW381929.1,

AA352782.1 , AI858883.1, AW785359.1, AW429636.1, AW488481.1, AA537627.1, AA271604.1 , W98752.1, W59077.1, AA009299.1 , AAl 99237.1 , AAl 18991.1 , AI286727.1 , Al 122511.1 , AA822533.1 , AA590075.1 , AA268809.1 , AA198139.1, AA051263.1, W64539.1, AW793665.1, AW484117.1 , AW484121.1. H31 197.1, AW528612.1, AA691124.1 , AW003500.1, AI415794.1, AU014893.1, AA606218.1, AW637653.1, AW452227.1, AA413355.1, AW739254.1, AW346361.1, AU056737.1, AU039136.1, AU030802.1, C92913.1, C90605.1, C90570.1, AA736083.1, T67650.1, AW844850.1, AW557138.1, AW445939.1, AW209584.1, AW191223.1, AJ273829.1, AV225068.1, AWl 12103.1, AI919153.1, AU076341.1 , AI888804.1, AI839037.1, AA696686.1, AA509465.1, AA377292.1, W15768.1, AC010552.3, AC007604.1, AP001005.1, AC020707.2, AC018350.2, AC015996.2, AC016708.3, AC027373.2, AC015972.3, AC016997.4, AC013404.1, AL355886.1, AL109769.2, AC012316.4, ACOl 1712.2, AC020991.3, AC023014.2, AC016226.1, AL354652.3, AL139334.3, AL161635.1, AL096782.3, AC044809.2, AC040951.2, AC012607.4, AC009070.5, AC012127.2, AC009871.5, AC013456.3, AC013398.2, AL139421.3, AL020985.1, ACOl 1606.6, AC060757.2, AC024991.2, AC040900.2, AC026539.2, AC021546.3, ACOl 1967.3, AC055860.1, AC007718.2, AC019253.3, AC022959.3, AC020754.2, AC014357.1 , AL356139.2 SEQ ID NO: 471 ZH1337/T3

NM_014890.1, U53445.1, Z46792.1, AC007557.3, AE001808.1, AL132949.1, AC004595.1, U60149.1, AL096867.15, Z79758.1, AL049692.13, AL031277.1, AC015985.8, AC005834.1, AL133244.1, AL139076.2, AL021171.1 , U58751.1, AW779584.1, C05084.1, AW779587.1, AW779590.1, AW751244.1 , AI606223.1, AW779641.1, AA990984.1, AI940062.1, AV343292.1, AV089962.1, AW86701 1.1 , AV292155.1, D75522.1, R54298.1, AW309190.1 , AV194167.1, AI587990.1, AA964335.1, AI068552.1, AA666699.1, AW467155.1, AW439057.1 , AW401003.1, AW325166.1, AW322018.1, AW168998.1, AV339384.1 , AV259982.1, AW104948.1, AI988870.1, AI854627.1, AI843433.1, AI835147.1, AI765820.1 , AI536969.1, AI494412.1, AA998598.1, AI429807.1, AI347598.1, AI228563.1, AI049016.1, AA629377.1, W97823.1, U31683.1, T69472.1 , AC022883.3, AC024938.7, AC069222.1, AC025231.2, AC021518.2, AL158159.3, Z92860.22, AC025318.2, AL353144.1, AP001836.1, AC06201 1.2, AC022074.11, AC026699.2, AC016619.5, AC008455.5, AC008973.3, AC008839.4, AC036108.2, AC067934.1, AC026563.2, AC018999.3, AC025677.2, AC019139.4, AC017103 , ACOl 1796.2, AC006759.3, AC006771.1, AL137244.14

SEQ ID NO: 472 ZH1337/T7

NM_014890.1 , U53445.1, L16887.1 , AC009294.8, AF096863.1, AF132287.1, AJ007556.1 , U23850.1, L38019.1, AB005241.1, D26070.1, AE003474.1, AE003418.1, NM_010585.1, AC004885.2, AF035831.1, AC005291.1, AC004061.1, AL031583.2, AL021453.1, X15373.1, J05510.1, L08753.1, AC022492.5, AC006438.3, AE003811.1, AC007843.6, AC007514.5, AC007630.3, AF087414.1, AC005562.1 , AF099917.1, AL158088.6, AL031666.3, AL031577.1, AL009177.1, AL034399.6, U49947.1, X95276.1, AB005233.1, L00638.1, Z14989.1 , U00731.1, AI435598.1, AI810391.1, AW303392.1, AI435391.1, AI921737.1 , AI401231.1, AI635663.1 , AA576134.1, AA424880.1, AI016121.1, AW026643.1, AW058260.1, AI817224.1, D57964.1, AI139164.1, AI086061.1, AA430212.1 , A1185109.1, AW295168.1, AA973230.1 , AA609225.1 , AW058427.1, AA857729.1, AI394490.1, AI378381.1, AI783720.1, AI334138.1, AI701330.1, AW083745.1, AI335721.1, AI378578.1, AI431237.1, AI804232.1, W69790.1, AI803115.1, AI013647.1, AWl 18656.1 , AA033582.1 , AW413495.1, AA925088.1, AA258605.1, AA033581.1, AA463851.1, AI371463.1 , AA795013.1, R78245.1, AA256689.1, AI381752.1 , F27521.1 , AA710489.1, AA030472.1 , D58330.1, AA568101.1, AA217400.1, D57334.1 , C16405.1, AA241058.1, C16415.1, D57996.1, AI473313.1, AA891483.1, AW346548.1, Z21882.1, AW363711.1, AA445957.1, AA986888.1 , AA204051.1, AW582813.1, F37351.1, AA266373.1, AI464359.1, AW214616.1, AV234619.1, AA432784.1, AV248227.1 , AW437163.1 , T84055.1 , AV229961.1 , AW363682.1 , AA170494.1, AA255796.1, AA463341.1, AV343730.1, AA546804.1, AA515391.1, AI181464.1, AA930120.1, AA172829.1, AC069222.1, AC022883.3, AC024938.7, AC023911.4, AP000812.1, AP000593.1, AC026770.3, AC020685.3, AL355315.2, AC025540.2, AC015833.3, AC012512.2, AC024157.1, AL158161.4, AC055835.2, AC068627.4, AC027396.2, AC067833.1, AC023131.4, AC025666.2, AC007902.2, AC016675.4, AC010014.5, AC014946.1, AC020107.1, AC010015.3, AL354827.1, AL139133.2, AP001095.2, AC018473.10, AC012022.5, AC010189.4, AC026249.2, ACOl 1095.3, AC024395.2, AC068725.1, AC024566.2, AC022098.5, AC008449.4, AC010303.4, AC010628.3, AC008584.3, AC068595.1, AC027768.2, AC012321.4, AC009032.5, AC027750.3, AC068055.1, AC031977.3, AC008718.3, AC023549.2, AC012052.2, AC022927.2, AC022309.7, AC022829.3, AC016130.13, AC024006.2, AC007345.2, AC023180.2, AC008342.11, AC018361.6, AC018515.2, AC021633.1, ACO 17903.1 , AC008004.4, AL157763.2, AL356272.1, AL161632.4, AL354669.1, AL161434.3, AL160274.2, AL121594.2, AP000706.1

SEQ ID NO: 473

ZH1341/T3

NM_006431.1, AF026166.1, AF026293.1, NM_007636.1, Z31553.1 , AB041570.1, AB022156.1, Z69239.1, AF144628.1 ,

AF074960.1, AC010685.3, AC004478.1, AC004225.1 , AL078646.29, U28047.1, AJ002428.1, AE003570.1 , AE003489.1, AE003431.1, AC006060.1, U80455.1, X95840.1, M60785.1, AL031227.1, T25350.1, T06605.1, AA047132.1, C17845.1, AA623003.1, W52697.1, T3481 1.1, AA045726.1, AW465425.1, T88741.1, T34157.1, AA136549.1, W00501.1, AI316379.1, T07709.1, AA030232.1, T32083.1, T30266.1, AL024449.1, T34904.1, AI986262.1, AI970836.1, AL024385.1, AA008392.1 , AA002279.1 , T36024.1 , AA220807.1 , AH 31881.1 , AA277806.1 , ALl 21077.1 , AAl 63893.1 , AA754987.1 , W34437.1, AA151835.1, AA306144.1, AA192116.1, AA300884.1, AAl 59771.1, AI084631.1, AH 14754.1, H02506.1, Rl 1411.1, AA854925.1, AI080278.1, R25131.1, AI683290.1, W54004.1, H33330.1, AI982815.1, T06606.1, N29115.1, AA151861.1, AI955296.1, AA051233.1, W30995.1, AA072866.1, AI992184.1, AA647081.1, H54133.1, AA031431.1, AI047227.1, AA634515.1, W53488.1, AW682117.1, AI342485.1, AA896241.1, AA537031.1, AA102856.1, W11223.1, AA163616.1, W32188.1, AA474269.1, AW464207.1, AA307507.1, AA874563.1, AA096900.1, AA920985.1, W71226.1, AAl 17392.1, AA198072.1, AI858401.1, AA163606.1, W76587.1, W10538.1, AW766196.1, AW079041.1, AI801143.1, AA065626.1, AW546786.1, AW546150.1, AI070959.1, AW276472.1, W13449.1, AW646329.1, AA268234.1, AW554539.1, AA896519.1, AW646056.1, AW640950.1, A W211726.1, AC018921.6, AC008730.4, AL049185.4, AC010758.2, AC010941.3, AC012530.2, AL137145.5, AC017068.3, AL162735.5, AL355147.1, AC009872.3, AC026722.3, AC022090.3, AC016553.4, AC025742.4, AC015669.4, AC024632.1, ACOl 1898.2, AL136988.4, AP001388.1, AC021662.8, AC015549.5, AC026314.3, AC068601.3, AC008375.6, AC008733.4, AC016085.2, AC053486.2, AC027062.2, AC010965.6, AC009194.2, AC018583.3, AC009555.4, AC009284.2, AC020726.3, ACOl 1706.13, ACOl 1267.2, AC017110.3, AC012499.3, AC022238.1, AC020525.1, AC014553.1, AC015253.1, AC006765.1, AL133519.15, AL355295.4, AL137021.3, AL157892.4, AL353633.2, AL162416.2, AL160284.3, AL160002.3, AL109655.4, AL121853.1, AP000858.1

SEQ ID NO: 474 ZH1342 T3

AF005067.1, AL080149.1, Z98885.1, AB033112.1, Z84485.1, NM_004634.1, AF176815.1, M91585.1, AE003841.1, AF066970.1, AE003706.1, AE003541.1, AE001865.1, AF152364.1, AF029776.1, ALl 10163.1, AL035608.11, AL009177.1, AL078635.1, AK001633.1, AB014600.1, NC_001144.1, NM_014643.1, NM_005284.1, AE003672.1,.

AE003466.1, AE003441.1, NM_007168.1, AC005358.1, AF001317.1, AF023538.1, AL121578.1, U69720.1, U69719.1, U69718.1, U69717.1, U69716.1, U24159.1, U18549.1, Z73145.1, Z73144.1, X63004.1, X63005.1, AB025284.1, L36150.1, AB020629.1, X07985.1, Z80168.1, Z80167.1, Z80166.1, Z80165.1, Z80164.1, Z80163.I, Z80162.1, Z80160.1, X66933.1, X66918.1, X71000.1, X70999.1, X70998.1, M31794.1, D86975.1, AL041903.1, AW176308.1, AW748208.1, H55108.1, AV118538.1, AA930693.1, AW369905.1, D76571.1, AJ397954.1, AW674903.1, AF034196.1, AI907910.1, T98019.1, AI594388.1, AI551828.1, AI514970.1, AA990859.1, AA948792.1, AA615805.1, AA461239.1, AA076152.1, W94477.1, W46356.1 , W38747.1 , N98297.1 , H65630.1 , H65071.1 , R93581.1 , R07789.1 , T97395.1 , T87592.1 , AW737888.1 , AW721225.1, AW598032.1, AW398350.1, AW376978.1, AW289794.1, AW216360.1, AWl 32493.1, AI076494.1, AI076474.1, AA653055.1, AA467735.1, AA448354.1, AC063971.1, ACOl 1610.6, AC008034.14, AC066599.1, AC018829.3, ACOl 1610.5, AC021996.1, AC022382.1, AC008117.2, AC012738.1, AC009739.2, AC005425.3, AC021030.5, AC068893.1, AC021031.2, AC021041.3, AC021033.2, AC022282.1, AC012285.1, AL138703.2, AL353576.1, AC010189.4, AC008737.6, AC023592.2, AC015867.2, AC007328.4, AC020260.1, ACO 17435.1, AC013251.7, AC010177.4, AC026765.5, AC023550.3, AC046185.2, AC009716.3, AC006452.3, AC026087.3, AC016791.4, AC019001.3, AC021808.3, AC022559.3, AC015844.4, AC012109.2, AC023303.2, AC015490.3, AC007582.6, AC016735.3, AC021979.1, AC017268.1, AC018307.1, AC016246.1, AC013388.2, AC013007.1, AC010837.1, AC008225.2, AC008029.2, AL355372.2, AL355804.2, AL355574.2, AL353722.2, AL139820.2

SEQ ID NO: 475 ZH1342/T7 Z98885.1, AL049402.1, AF005067.1, AL080149.1, AJ276620.1, Z77661.1, AC010143.3, AE003520.1, AE001419.1,

AC004186.1, Z98551.1, AP000517.1, AB023055.1, AB023054.1, AC008082.12, AC006508.2, AC005293.1, AC002984.1, AL163231.2. Z97348.1, ALl 17204.1, AL137082.1. Z92846.1, AP001686.1, AI912611.1, AA194257.1, AW511409.1, AI350842.1 , AI497969.1 , AI991928.1 , AI061156.1 , AA744999.1 , AW367919.1 , AI697635.1 , D53392.1 , AI680322.1 , HI 1244.1, AU021249.1, T07017.1, AW464067.1, AA675465.1, AU021226.1, H07921.1, AA675514.1, AA096761.1, AI316859.1, AA675570.1, H11599.1, AA415581.1, AI605086.1, AV232516.1, AA140518.1, AA423260.1, AA407537.1, L26667.1, AV308339.1, AV362645.1, AI136270.1, AV221817.1, AV232046.1, AV309058.1, AA538272.1, AV295672.1, AA881466.1, AI909924.1, AV317023.1, AI610452.1, A V272219.1, AA253945.1, AA163258.1, AW151974.1, AA267651.1 , D25843.1 , AV362354.1 , AA602506.1 , N55893.1 , T60706.1 , AW731089.1 , AW556255.1 , AW539783.1 , AW537016.1, AV289382.1, AV288374.1, AV287917.1, AV281808.1, AWl 13811.1, AV171764.1, AV150903.1, AV136562.1, AV132076.1, AV036654.1, AV033511.1, AV018891.1, AV017847.1, AV014616.1, AV012475.1,

AV004049.1, AU041826.1, AI194930.1, AH 94429.1, AI158937.1, AI158907.1, AU017925.1, AI042738.1, AA880883.1, C87705.1, C85054.1, AA146382.1, AC026436.2, AL355335.2, AC018613.3, AL355821.3, AL356099.1, AC017268.1, AC008225.2, AC008029.2, AP001205.1, AC016938.3, AC023406.2, AC021184.2, AC019498.1, AC069202.1, AC007383.3, AC022738.3, AC004688.6, AC019213.4, AC012299.2, AC019247.3, AC014129.1, AC004709.3, AJ009617.3. AL353748.1

SEQ ID NO: 476

ZH1349/T3

NM_014633.1, D63875.1, NM_009431.1, L49502.1, Z64358.1, Z60774.1, Z56379.1, AF106950.1, AE003734.1, AF035396.1, NC 001136.2, U33050.2, AE003665.1, AF168787.1, AC005251.1, NM_011444.1 , AC006932.8, AC004600.2, AC004259.1, AC004364.1, AC003981.1, AL163293.2, AJ271782.I , U74488.1, Z78411.1 , X14061.1, AJ010604.1 , X65657.1, APOO 1748.1 , APOO 1629.1, AB028606.1, U03673.1, X78854.1, AB006330.1, AI972468.1, AL037613.1, AI956252.1, AW533634.1, AH 19107.1, Z20387.1, AV126363.1, AU038895.1, AV409090.1, AW322594.1, AV286414.1, AV047689.2, AI528773.1, AC025744.5, AC023566.3, AC009612.3, AC055874.2, AC013464.2, AC019126.4, AC009699.6, ACOl 1980.3, AC020573.2, AC008309.6, AC020256.1, AL136178.3, AL354753.1, AL161645.2, AL161616.4, AP000945.2, AP000940.2, AP000914.2, AC068797.3, AC023796.17, AC044841.2, AC068051.2, AC009682.3, AC027796.2, AC068471.1, AC027040.2, AC019005.4, AC026819.1, AC009252.8, AC016688.4, ACOl 1875.3, ACOl 1678.4, AC023669.3, AC010708.9, ACOl 1329.5, AC010130.4, AC021758.1, AC013765.2, AC017332.1, AC013260.1 , AC012422.1 , AL137250.3, AL133167.1, AL157364.1 , AP001320.1, AP000848.1, AP000663.1

SEQ ID NO: 477 ZH1349 T7 NM_014633.1 , D63875.1 , NM_009431.1 , L49502.1 , AC004796.2, NM_003670.1 , AC006989.3, U78027.1, AL034370.1 , AL031007.1, AL035422.12, AB004066.1, AC025744.5, AC027377.2, AC024240.2, AC023374.2, AC010144.2, AC060757.2, AC019025.4, AC0551 19.2, AC009506.3, AC009315.3, AC017073.4, AC060823.1, AF235105.1, AC024192.2, AC021807.3, AC021192.3, AC025292.6, AC019229.4, AC015974.4, AC022184.2, AC023000.2, ACOl 1303.4, AC010948.2, AC009907.2, AL138772.2, AL137783.4, AL133476.4, AH 40348.1, AW575179.1 , AA313178.1, AI302523.1 , AI343468.1 , H88182.1, AI924726.1, AI279164.1, AI675472.1, AI694570.1, C05893.1,

AI935120.1, AW573224.1, AW070842.1, W27038.1, H49849.1, AW338994.1, AWl 73599.1, AWl 92729.1, AI935109.1, AA775398.1, AI418449.1, AA649176.1, AA977091.1, H99003.1, AI921383.1, AAl 1 1977.1, AW057891.1, N45992.1 , AA903179.1, AA725733.1, AA769208.1 , AI050019.1, AA972949.1, AA907605.1, AI650806.1 , AI040043.1, AA976298.1, AA663521.1 , AA599535.1, AI392652.1, W15276.1, N20975.1, AA382400.1, AI015136.1, AI830477.1, AI702518.1, AA448303.1, AA133685.1, D62244.1 , HI 1922.1, Z21605.1, AA883364.1, AA120987.1 , H71942.1, T18935.1,

AW236770.1, H88183.1, AA970675.1, AA906369.1, AA778495.1, AA569907.1, AF074673.1, AH 10766.1, T36008.1, H49850.1, AA448439.1, H13635.1 , H14826.1, H72101.1, AI882558.1, AA990321.1 , AI231369.1, AA794084.1, AW391124.1, AA126436.1, AI540567.1, AW338921.1 , AW008252.1, AI983861.1, AI926982.1, AI811452.1, AI801550.1, AI697038.1, AI692253.1, AI680537.1, AU061411.1, AL047652.1, AI384049.1, AI274740.1, AI129012.1, AI050840..1;, AA935903.1, AA502930.1, AA459382.1, W39236.1 , H50006.1, H47024.1, T40923.1

SEQ ID NO: 478

ZH135/T3

AB020660.1, AC004560.1, AC002335.2, ACOl 1749.2, NM_014119.1, NM_001385.1, AC010135.3, AC004021.1, AF090901.1, AE001806.1, AE001523.1, AF003694.1, L441 17.1, AB008681.1, AB004678.1, AP000500.1, D78011.1, NM_000206.1, NM_014892.1, AC022492.5, AC006264.3, AE003605.1, AE003528.1 , AF225899.1, AC003093.1, NM_007167.1, AC006007.1, AF191067.1, AF191066.1, AF191065.1, AF199490.1, AF055470.1 , AFl 05999.1, AC005599.5, AC006524.1 , ALl 63231.2, AL023496.1, AL035684.25, AL034552.22, AL035555.10, Z93928.1, AJ243221.1, U12968.1, AP001686.1, APOOl 1 16.1 , Dl 1086.1, M59706.1, AB013356.1 , AB029039.1, M60729.1, M37157.1, AW301888.1, AI568547.1, AI583768.1, AI936629.1, W27274.1, M62235.1, AI480106.1, W25908.1 ,

AI695267.1, AW877787.1, AW028690.1 , N62788.1 , AA055767.1, H35697.1, AI154653.1, AA684914.1, AI314818.1, AW304578.1, AW701243.1, AA730316.1, W27573.1, AA747507.1, AW701235.1, AU062105.1 , AU054035.1, AU039346.1, AW779331.1, AW612623.1, AW612325.1, AW449054.1 , AW300369.1, AW271596.1, AW257923.1 , AW243196.1 , AW242821.1, AWl 97670.1 , A W028159.1 , AW024860.1 , AW024852.1 , AI991537.1 , AI936331.1, AI912813.1, AI831914.1, AI765642.1, AI672449.1, AI629008.1, AI478498.1, AI469047.1, AI291 149.1, AH 14808.1, AI033077.1 , AA704840.1 , AA704236.1 , W03786.1 , N98259.1 , R91017.1 , A W819289.1 , AW819284.1 , AW768498.1 , AW768346.1, AW686186.1, AW504627.1 , A W391566.1 , AW211317.1, AW193466.1 , AW183964.1 , AV258097.1, AW081914.1 , ALl 10372.1, AI864987.1, AI860562.1, AI684615.1 , AI440025.1, AI370166.1, AI091610.1, AA988240.1, AA832000.1, AA807563.1, AA632170.1 , AA447899.1, AA132727.1, AA100128.1 , AA099559.1, AA054459.1, W61266.1, N54821.1, R911 1 1.1, Z29120.1, AL157758.5, AC016693.4, AC008574.3, AC021709.2, AC022756.2, AC021050.4, AC055748.5, AC021818.3, AC012239.3, AC025400.2, AC024412.2, AC018987.3, AC012511.3, AC006184.1, AL139089.4, AC068889.4, AC023509.9, AC021865.7, AC036240.3, AC013487.3, AC021 158.2, AC024557.1, AC015566.4, AC013262.3, AL353999.1, AP001011.1, AP0OO8O5.1, AC005973.4, AC034257.2, AC036184.2, AC068914.1, AC036131.2, AC013335.5, AC010297.3, AC008722.4, AC068464.1, AC009836.3, AC024603.2, AC026975.2, AC037428.1, AC022402.2, AC010066.5, AC014420.1, AC014889.1, AC015913.2, AC016400.1, AC016110.1, AL139349.16, AL096865.22

SEQ ID NO: 479 ZH135/T7 AB020660.1, AC002336.2, NM H4119.1, NM_001385.1, AF090901.1, AC006365.3, AEOOl 523.1, AB004678.1,

D78011.1, ACOl 1504.2, AC022492.5, AE003522.1, AE003419.1, U82695.2, AC005251.1, AC003093.1, AF191067.1 , AF191066.1, AF191065.1, AC007535.3, AF007865.2, AL079352.3, AL049588.11 , AL121806.2, AL034552.22, AL132769.1, U12968.1 , M59706.1, J03498.1, AW301888.1, AI568547.1, AI583768.1, W27274.1, AI936629.1, M62235.1, AI480106.1 , AI695267.1 , AW877787.1 , W25908.1 , AW028690.1 , N62788.1 , AW304578.1 , AA055767.1 , AA730316.1 , AA747507.1, AI154653.1, H35697.1, AA684914.1, AI314818.1 , AW193466.1, AW779331.1, AW612623.1, AW612325.1, AW449054.1, AW300369.1, AW271596.1, AW243196.1, AW242821.1, AW197670.1, AW028159.1, AW024860.1 , AW024852.1 , AI991537.1 , AI936331.1 , AI912813.1 , AI831914.1 , AI765642.1 , AU062105.1 , AI672449.1 , AU054035.1 , AI629008.1, AI478498.1, AI469047.1, AU039346.1, AI291149.1 , AI254569.1, All 14808.1 , AI033077.1, AA764892.1, AA704840.1, AA704236.1, AA213666.1, W03786.1 , N98259.1, R91017.1, AW211317.1, AV258097.1, AI998589.1 , AI377934.1, AU007984.1 , ALl 57758.5, AC021709.2, AC022756.2, AC016796.2, AL137840.9, AC021050.4, AC025400.2, AC024412.2, AC010243.3, AC016555.4, AC026005.2, AC036240.3, AC026131.2, AC018625.4, AC013656.3, AC012239.3, AC022474.3, AC023168.6, AC013487.3, AC010897.3, AL139089.4, AC021645.6, AC034257.2, AC036184.2, AC027034.7, AC068914.1, ACOl 1454.3, AC009836.3, AC037428.1, AC012656.4, AC034118.1, AC024431.2, AC013576.4, AC01381 1.3, AC023981.2, AC018699.2, AC015703.2, AC015425.1, AC020218.1 , AC007573.4, AL121905.14, AL158197.6, AP001483.1, APOOl 160.1

SEQ ID NO: 480 ZH1377/T3 AB006198.1, Y14314.1 , AB014722.1 , AB014721.1, AF129931.1, AF147725.1, L20095.1, L20680.1, AC010494.4, AE003493.1 , NM H5933.1, AC011462.4, AE003765.1, AE003594.1 , AC000029.17, AF161448.1, AC004825.2, AF077202.1, U39402.1, AC004196.1, AL163296.2, AL031729.16, Z97832.11, AL049853.1, ALl 12418.1, AL021930.1, AP001751.1 , L09190.1, AP000510.2, AKOOl 152.1, AP001046.1 , AB023048.1, AB023212.1, M15100.1 , AB017022.1, W27222.1, AW402760.1, AL047890.1, AI594593.1, AA607769.1, AW820827.1, AI120962.1, AI509410.1, AI908693.1, AW393484.1, AA621914.1, AW652595.1, AI964608.1, AI642054.1, AA979854.1, AA979772.1, AI661459.1, AJ228935.1, AA751847.1 , AW758324.1, AI827037.1, AV417239.1, AW615491.1, AW474981.1, AW074946.1, AW067038.1, AW006944.1, AI924762.1 , Al 880663.1, AI880658.1, AI709253.1, AI708293.1, AI708235.1, F33596.1, AI666115.1 , AI570650.1, AI459983.1, AI420748.1 , AWl 8553.1, AI370584.1 , AI339191.1, AI333234.1, AI277699.1, AI268051.1, AI140031.1, AI092938.1 , AI090805.1, AI026809.1, AA995593.1, AA910393.1, AA877021.1, AA807417.1, AA804750.1, AA742573.1, AA584264.1, AA574096.1, AA563619.1, AA527394.1, AA364686.1 , AA361058.1, AA321138.1, AA316267.1 , AA284615.1, AA282382.1, AA280277.1, AA279851.1, AA229404.1, AA151350.1, AA149268.1, AA134303.1, AA082333.1, AA07151 1.1, AA046848.1, AA026455.1, W95678.1, W76586.1, W51757.1, W52002.1, W16750.1, W05408.1, W04465.1, N84053.1, N80509.1, N78206.1 , N76058.1, N70547.1 , N59651.1, H54880.1, R08131.1, R07233.1, T97050.1, T91349.1 , T39397.1, AP001201.4, AP000592.2, APOOl 191.1, AP000586.2, AC008683.4, AC018996.3, AC046141.3, AC068951.1, AC022120.4, AC008405.3, AC008658.2, ACOl 1069.6, AC013189.1 , AC068992.3, AC055744.2, AC027309.2, AC027307.3, AC022091.3, AC010377.4, AC008453.4, AC008450.3, AC064317.1, AC064056.1, AC052499.1, AC044355.1, AC045178.1, AC041917.1 , AC040463.1, AC034640.1, AC028038.1, AC021328.3, AC007903.2, AC026184.1, AC018734.2, ACOl 1233.2, AC02395O.2, AC010899.3, AC015903.1, AC014411.1, AC018045.1, AC006579.3, AL136136.2, AL1361 19.3, AL109955.13, AL135939.9, AL133282.13, AL133284.12, AL032818.2

SEQ ID NO: 481

ZH1377/T7

Y14314.1, AB006198.1, AF129931.1 , AB014721.1, AB014722.1 , AFl 19856.1, AF109680.1, AF105334.1, AL137786.2, AE003430.1, AL033125.1 , NM_008217.2, U86408.2, Z82068.1, AL132966.1, NM_016558.1, AF207829.1, AF204271.1, AE003639.1, AE003541.1, AE003451.1, AE001863.1, AC005443.1, AF017113.1 , U43537.1, AL136000.2, AL163652.1, AL133445.2, AL031295.1, Z99122.1, AB026898.1, AP000498.1 , Z99121.1, X83381.1, AJ233717.1, AI831753.1 , AI830162.1, AW082054.1, AI784561.1, AI751435.1, AW296164.1, AI076937.1, AI417592.1, AI832417.1, AI418373.1, AW471179.1, AW373854.1, R00027.1 , AA873591.1, AW577472.1, AI299276.1 , AA994926.1, AW193590.1 , AA719303.1, AI352467.1, AA937579.1, AA150708.1, AI887024.1, AW076002.1, C15250.1, AI167599.1, C14562.1 , R62890.1, AA436728.1, W72736.1, AW652595.1, W77888.1, AI642054.1, AI024520.1, AA424118.1, AI648860.1, W26153.1, AA198906.1, AA599522.1, AA719206.1, C04465.1 , AI879475.1, AI598660.1, C03203.1, AA923037.1, R89163.1, AW823000.1, AW336989.1, AW228635.1, AA738331.1, AI190229.1, AI133253.1, T15806.1, W59275.1, AA159334.1, AA150810.1, W08514.1 , AA562404.1, AA524379.1, AI504540.1 , AA535861.1, AH 1 1403.1, AA268523.1, AW601644.1 , AH 12699.1, AI228721.1, AW376834.1, AI501993.1, D82373.1, AA074115.1, AI828039.1, AI368786.1,

AA007824.1, C06261.1, AV343384.1, AA881513.1 , AV225592.1, AV354003.1, AW116461.1, AA159405.1, AI643510.1, D82306.1 , AV308997.1 , AI246103.1 , AV316572.1 , AV314799.1 , AI330432.1 , Al 120962.1 , AV314752.1 , AA708028.1 , AW602080.1, T89567.1, AW581697.1, D83891.1, AV100082.1, AV097253.1, AV032808.1, AP001201.4, AP000592.2, AP000586.2, APOOl 191.1, AC023849.1, AC012934.1, AL022597.5, Z92865.1, AL022596.1, AC009188.4, AC036224.2, AC034229.2, AC011498.4, AC025882.2, AC005079.2, AC009470.3, AC026283.2, AC015938.3, AC014337.1, AC014984.1, AC020327.1, AC005044.1, AC005459.1, AL109965.22, AL355837.1

SEQ ID NO: 482 ZH1381/T3 NM_014673.1, D14659.1, AF146342.1, AC004741.1, AC005343.1, AL049838.3, AL132668.2, NC_001224.1,

AF152364.1, AL161572.2, AJOl 1856.1, Z70680.1, AL031703.11, AC007878.2, AE002473.2, AE003844.1, AE003787.1 , AE003676.1 , AE003519.1, AE003422.1, AE003217.1, AE002613.1, NM_011376.1, NM_008062.1, AC004926.2, AC005521.1, AC0050O4.3, ACOl 1713.2, AC006065.3, AF044676.1, AL132641.2, AL162755.2, AL162754.2, AL137228.2, U88534.1, AL021395.15, AL021406.1, U47058.1, U59516.1, U59515.1, L40698.1, U53501.1, U40575.1, U41028.1, X07467.1 , Z1191 1.1, Z84471.1, AB013484.1, M99599.1 , AB020872.1, M26655.1, AL048716.3, AL038161.1, AW204529.1, AA447858.1, AI557375.1, AA821444.1, AW583644.1, AW583578.1, AA385797.1, AA560410.1, AA870575.1, AA301506.1, AA471359.1 , C83495.1, C82639.1 , AA003181.1, AI525324.1, AA163000.1, AA187086.1, AA855729.1, AW644280.1, AW765060.1, AI156263.1, AW646028.1 , AA638895.1 , AA137986.1, AA545015.1, AI204083.1, AA248265.1, AA687160.1, AW639641.I, AI555299.1, AI616839.1, AW303995.1, AI669342.1, AA530808.1, AW209495.1, AI636359.1, AW009849.1, AI669343.1, AW548701.1, AV180860.1, AV178105.1, AV177100.1, C54380.1, C36065.1 , D34365.1, D33956.1, D33401.1, D27654.1, AW623143.1, AW623051.1, AW623049.1, AW621371.1, AW578603.1 , AW442863.1, AW229969.1, AW219265.1 , AW096441.1, AW092722.1, AI921265.1, AI789557.1, AA894979.1, AA839723.1, C79227.1, AC022634.3, AC026950.2, AC012206.3, AP002079.1 , AP002078.1, AC018351.8, AC022295.7, AC062037.2, AC017100.3, AC010149.4, AC023940.2, AC022960.2, AL356371.1, AL355792.1, ACOl 1257.3, AC025764.3, AC027423.2, AC023592.2, AC013323.5, AC015564.3, AC016105.3, AC015594.1, AL121996.5, AL109923.21 , AL355352.3, AL139190.3, AL139418.1, AL049803.1, APOO 1990.1 , APOO 1974.1, AC062004.2, AC068774.2, AC048384.2, AC026046.4, AC022414.3, AC025431.3, AC062001.1, AC024031.2, AC025003.2, AC022997.3, AC018793.4, AC021 134.4, AC016035.3, ACOl 1568.3, AC021225.3, ACOl 1855.2, AC012390.5, AC015675.1, AC012142.1, AC008227.2, AC007905.1, AL356355.2, AL353092.3,

SEQ ID NO: 483

ZH1381/T7

NM_014673.1 , D14659.1, AC004492.1, AC009233.3, Z99133.1, AF178030.1, AC004838.2, AF048726.1, AL109654.22, AL031430.1, AJ243213.1, AL138651.1, AL033392.5, Z81364.1, AC006231.18, AC005875.2, AC007421.12, AF028834.1, AL160191.2, Z99135.1 , AJ232463.1, AJ232461.1, AJ232460.1, AJ232459.1 , AJ232458.1, AJ232456.1, AJ232466.1, AJ232465.1, AJ232464.1 , AJ232454.1, AJ232501.1, AJ232462.1, ALl 17340.3, L31948.1 , ACO 19209.3, AE003578.1, AE003426.1, AC006229.17, AC006472.1, AC004802.1, ALl 10292.4, AL163219.2, AL034556.3, AP001674.1, AP000477.2, AC009478.4, AC006332.3, AE003518.1, AE003507.1, AC007151.2, AF030694.2, AC006150.2, AC005185.1, AC004609.1, AC004075.1, AC002412.1, AL163214.2, AL121808.2, AL136296.2, Z95116.1, AL022159.1 , AP001669.1 , U07978.1, AI636359.1, AI669343.1 , AI669342.1, AI566150.1, AI027953.1, AW276600.1, AI339009.1, AA447703.1, AI147898.1, AA88781 1.1, AI679455.1, AA873375.1, AA836064.1, AA534251.1 , AI422353.1, AA745251.1, AW130877.1, AA708596.1, AW168287.1, AW303995.1, AI420890.1, AI677854.1 , AA935810.1, AA938493.1, AA687160.1, AA311297.1, T27967.1, AA301507.1, AA935814.1, AA447858.1, N50202.1, AA683177.1, AW009849.1, AA545015.1, AI555299.1, AA137986.1, N68048.1, AA530808.1, AW198055.1, AW592606.1, AA181333.1, AW209495.1, AI104356.1, AA855729.1 , AA638895.1, AA893851.1, AI014068.1, AI234816.1, AI204083.1, AA067766.1, AW123869.1, AI557375.1, AW539200.1, AI556341.1 , AI102630.1, AV171265.1, AI156263.1, AW204529.1, AA560410.1, AW646028.1 , L26817.1, AW764367.1, AA469099.1, AA797564.1, AI843449.1, AV250940.1, AV359988.1, AV260102.1, AV257129.1, AV256840.1, AV253184.1, AV251229.1, AV249657.1 , AWl 24329.1, AVI 56582.1 , AVI 72897.1, AV152635.1 , AV151001.1, AV127867.1, AV122251.1, AVI 13481.1, AV088039.1 , AV087948.1, AV087721.1 ,

AV060620.1, AV058322.1, AV056999.1, AV048088.2, AV015847.1, D19285.1, Z36450.1, AV033019.1, AV085824.1, AV 127868.1 , AV040300.2, AV129270.1, AV120629.1, AV060547.1, AA286921.1 , AC022634.3, AC019351.3, AC025826.1, AL138828.4, AC058784.2, AL354717.1, AC068992.3, AC053499.2, ACOl 1192.2, AC018608.4, AC023075.2, AC016437.2, AL158149.3, AL138974.2, AL139234.1, AC069066.1, AC026105.4, AC008705.4, ACOl 1369.3, AC027212.2, AC026523.2, AC024736.3, AC010819.4, AC024640.2, AP000878.1, AC010176.7, AC026119.5, AC023757.4, AC027567.2, AC023666.3, AC027073.2, AC025999.3, AC025380.2, AC004688.6, AC008182.1 , AL162715.3, AL354836.1, AL162738.2, AL353789.1, AC009772.4, AC012293.9, AC015583.6, AC067946.2, AC008794.6, AC008396.4, AC051662.2, AC068360.1, AC010773.4, AC068065.1, AC066694.2, AC025846.2, AC015825.4, ACOl 1273.3, AC019267.3, ACOl 1154.3, AC015967.5, ACOl 1936.4, AC022926.2, AC018835.3, AC024625.1, AC010105.4, AC020515.1 , AF165178.1, AC006889.2, AL355978.2, AL356254.1, AL158214.3, AL049181.4, AP001489.1, AP001316.1, AL020987.1

SEQ ID NO: 484 NGO-Pr- 102,Mitochondrion AC022634.3, AC019351.3, AC025826.1, AL138828.4, AC058784.2, AL354717.1, AC068992.3, AC053499.2, AC011192.2, AC018608.4, AC023075.2, AC016437.2, AL158149.3, AL138974.2, AL139234.1, AC069066.1, AC026105.4, AC008705.4, ACOl 1369.3, AC027212.2, AC026523.2, AC024736.3, AC010819.4, AC024640.2, AP000878.1, AC010176.7, AC026119.5, AC023757.4, AC027567.2, AC023666.3, AC027073.2, AC025999.3, AC025380.2, AC004688.6, AC008182.1, AL162715.3, AL354836.1, AL162738.2, AL353789.1, AC009772.4, AC012293.9, AC015583.6, AC067946.2, AC008794.6, AC008396.4, AC051662.2, AC068360.1, AC010773.4, AC068065.1, AC066694.2, AC025846.2, AC015825.4, ACOl 1273.3, AC019267.3, ACOl 1154.3, AC015967.5, AC011936.4, AC022926.2, AC018835.3, AC024625.1, AC010105.4, AC020515.1, AF165178.1 , AC006889.2, AL355978.2, AL356254.1 , AL158214.3, AL049181.4, AP001489.1, AP001316.1, AL020987.1, AI133129.1, AI174835.1 , AA837506.1, AI174687.1, AA845434.1, All 14646.1, AA608740.1, AA658828.1, AA828080.1 , AA808070.1 , AA857455.1, AA773323.1, AI133174.1, AA583915.1, AH 10847.1, AA904301.1, AW476695.1, AA456337.1,

AL038877.1, AA633895.1, AL048271.1, AA808161.1, AA630140.1, C18439.1, AA507255.1, AA805233.1, AI207408.1 , AA984203.1, AI571104.1 , AI174794.1 , AA156220.1, AA553443.1, AA176583.1, AA856778.1, AA650251.1, AA176822.1, AI814544.1, AA736437.1, AI174730.1, AA467942.1, AI557498.1, AW772675.1, AA564555.1, AI718315.1, AA886828.1, AA689243.1, AA630233.1 , AA897055.1, AA575992.1, AA661906.1, AA577503.1, AA548340.1, AI133039.1, AA602775.1, AI832559.1 , AA193235.1, AA131048.1 , AA595999.1, AA075714.1, AA757434.1, AL036895.3, AA582747.1, AA209389.1, AA196849.1, AA582810.1, AI685974.1, AI208586.1, AA548826.1 , Cl 8291.1, AI557663.1, Al 133693.1 , AL047524.1, AA548207.1 , AA889509.1, AA192336.1, AA595509.1, AI557433.1, AA679483.1, AI557309.1, AA554794.1, AA516479.1, AA143798.1, All 14473.1, AA548920.1, AA860683.1, AA614220.1, AA554088.1, AA548557.1 , AI174817.1, C17039.1, AW867453.1, AL038831.2, AA595385.1, AA402635.1, AW867465.1, AW849013.1, AI285116.1, AA514820.1, AA554459.1, AW607854.1, AC021965.3, AC008670.3, AL161450.4, AC018856.3, AC013437.3, AC066616.2, AC025429.2, AC021755.4, ACOl 1821.4, AC013297.4, AC016052.2, AC022827.2, AC023374.2, AC022861.2, AC067925.1, AC021473.3, AC012363.1, AC021835.3, AC025395.2, AC007595.3, AC068981.1, AC021753.3, AC023652.3, AC016760.3, AL354751.2, AC009658.5, AC025916.2, AC012128.3, AC009907.2, AL138765.3, AL355177.1, AL355176.1, AC006393.6, AL133513.2, AC034300.2, AC019324.3, AC007670.2, AC012433.5, AP001499.1, AC025643.3, AC002987.1, AL160052.3, AC022148.4, ACOl 1419.4, AC008586.4, AC026918.2, AC060234.2, ACOl 1965.3, AC035139.3, AC023387.2, AC009882.3, AC034206.1, AC015948.3, AF205591.1, AC005848.1, AL355348.3, AL158831.5, AC002490.1, AL354696.1, AL160009.3, AL157712.2, AL353731.1, AL138690.3, AP001453.1, AP001205.1, AP000867.1, AP000573.2, AP000424.1

SEQ ID NO:485

ZH1291/T3

NC_001807.2, J01415.1 , X93334.1, V00662.1, X62996.1, X54629.1, L08441.1, D38112.1, NM_000256.1, Y10129.1,

X84075.1, NC_001644.1, D38116.1, AF004341.1, X93335.1, NC_001643.1, D38113.1, NC_001645.1, X93347.1, D38114.1, AF134583.1, NC_002082.1, X99256.1, NC_001646.1, D38115.1, NC_002083.1, X97707.1, Z79419.1, Z79403.1, Z79459.1 , AJ252237.1, U35430.1, AF030463.1, AF030273.1, NC_001602.1, X72004.1, NC .001601.1, X72204.1, AL163203.2, AL050302.2, AL049911.2, NC_002078.1, AF030460.1, AF030459.1, Y18475.1, NC_001821.1, Yl 1832.1, U01924.1, M85148.1, AF030279.1, AF030278.1, AF030277.1, AF030275.1, NC_001567.1, J01394.1, V00654.1, NC_001992.1, NC_001321.1, AF030276.1, X61145.1, Y18001.1, AF030467.1, NC_002391.1, NC_002009.1, AF030458.1, AF061340.1, Y19192.1 , J01435.1, NC_000934.1, AF030466.1 , AJ224821.1, NC_001808.1, Y07726.1 , NC .000890.1 , AB015962.1, NC_001665.1, AF030464.1, M27315.1, X14848.1, NC_000886.1, AB012104.1, NC_001913.1, AJ001588.1, NC_001640.1, X79547.1, L01700.1, AF030462.1, AB042523.1, AB042524.1, AB042432.1, AF030272.1, AF030472.1, AF030271.1, AF030489.1, AF030274.1, AF168103.1, AF030473.1, NC_001325.1 , X63726.1, AF168095.1, AL037681.3, AL038791.2, AI174902.1, AH74754.1, AI133672.1 , AI133286.1, AH 14699.1, AH 14569.1, All 14553.1, AI133302.1, AL048390.1, AI133486.1, AI557258.1 , AH 11183.1, AI766340.1, All 74851.1, AA737196.1 , AA736456.1, AI133013.1, AA652417.1 , AA593688.1, AA581699.1, AA563780.1, AA526831.1, AA172073.1, AA575833.1, AW027357.1 , AL036838.3, AA648603.1, AA599168.1 , AA582799.1, AA555226.1, AA551039.1, AA514972.1 , AA575830.1 , AA574324.1 , AA085983.1 , AA075391.1 , AW029484.1 , AI709043.1 , AA723026.1 , AA631499.1, AA629984.1, AA587808.1, AA579760.1, AA554729.1, AA196384.1, AL036246.3, AA642990.1, AH 33348.1 , AA595314.1 , AA578591.1, AI207615.1, AA593715.1 , AA490067.1 , AI863904.1 , Al 133323.1 , AA639334.1 , AA161487.1, AI721239.1, AI285534.1 , AI279442.1, AA886649.1, AA738012.1 , AA586605.1 , AA583348.1, AA581810.1, AA603127.1, AI707535.1, AA548197.1, AI720161.1, AI174301.1, AI147501.1, AA640938.1, AA548398.1, AA195996.1, AI833205.1, AA641109.1, AA526496.1 , AAl 74081.1, AW149525.1, AI749163.1, AI720981.1, AI565971.1, AI280900.1, AA565769.1, AA6046U.1 , AA736459.1, AA582715.1, AA196392.1, AA178939.1, AW027020.1, AI720842.1 , AA643267.1, AI814650.1, AA583501.1, AI709143.1, AI720252.1, AI719365.1, AI970662.1, AC012092.3, AC021965.3, AL157387.1, AC068619.1, AC009573.3, AC044785.1, AC021029.3, AC021035.3, AL355819.2, AL163540.3, AL354822.1, ACOl 1821.4, AC013297.4, AC016052.2, AC009960.4, AC000382.1, AC016050.3, AC025431.3, AC007595.3, AL137218.1, AC016147.7, AC026079.2, AC067925.1, AC021473.3, AC022192.2, AC027762.2, AC013632.3, AC066616.2, AC027471.2, AC024454.2, AC024170.1, AC024975.2, AC025395.2, AL162611.4, AC024252.3, AL353626.1, AC012363.1, AC022600.1, AL354697.4, AL354817.3, AC036170.2, AC025678.2, AC009714.3, AC021822.3, AL161450.4, AL158147.4, AL161614.4, AC066596.1 , AC013437.3, AL355304.3, AL162272.3, AL137244.14, AC022861.2, AC006393.6, AL162726.3, AC058808.1, AC018890.3, AC068239.1, AC068179.1, AL118520.15, AL354751.2, AC027456.2, AC068010.1, AC010388.4, AC020688.3, AC009577.3, AC021821.3, AC040973.2, AC041013.2, AC021076.3, AC036102.2, AC026839.2, AC025986.2, AC013799.3, AC005507.6, AC013452.3, AL139232.4

SEQ ID NO: 486

ZH1291/T7

AL163203.2, AL049911.2, AL050302.2, AC020663.1, AL031651.33, AL109952.15, AC005839.1, AC000095.3, AC007957.35, ACOl 1450.4, AC022073.13, AC008101.15, U91326.1, AC004854.2, AC005157.1, AC005231.2, AC009320.7, AC002544.1, AFl 1 1169.2, AC007193.1, AC007191.1, AC006953.1 , AC000015.2, AC005952.1, AC005954.1 , AC005722.1 , AC005772.1 , U37672.1 , AC005612.1 , AC005152.1 , AC003104.1 , AC004560.1 , AC003051.1, AL034555.2, AL133249.1, AL049839.3, AL080242.i l, AL096762.5, AL096702.10, Z93024.1 , Z82097.1 , AL022336.1, AL022313.1, AL022238.1, AL022311.5, AL009183.10, AL034410.8, AL009051.1, AL021397.1, AL034394.2, AL031311.1, AL109753.9, Z73359.1, Z73360.1, AP000966.2, AP000557.2, AP000556.2, AF156673.1, AC005137.1, AC009363.4, AC003999.1, AC004740.1, AC004935.1, AC005102.1, AC009516.19, AF129756.1, AC007283.3, AC006138.1 , AC005884.1 , AC004477.1 , AC005031.1, AC004771.1, AC005330.1 , AC005177.1 , AC004752.1 , AC002312.1, AC000379.1, AL109984.14, AC000393.1, AL132774.20, AL133297.1, AL031428.9, AL050348.20, AL096703.14, AL050312.8, AL033543.6, AL031846.2, Z74617.1, Z95125.1, AL033376.17, M89651.1, AP000513.1 , AP000688.1, AP000177.1, AP000558.1, AP000101.1, AL035072.16, AL033517.1, Z69918.I, AP000548.1, AW170035.1, AW373574.1 , AA829065.1 , AI637628.1 , AI570010.1 , AI537590.1 , AA773989.1 , AA230128.1 , AAl 69163.1 , AW849803.1, AW514811.1, AW305371.1, AW275623.I, AW131043.1, AI783494.1, AI750173.I, F17555.2, AI475857.1, AI247199.1 , Al 124706.1 , AA912287.1 , AA659608.1 , AA631507.1 , AA508104.1 , AA502532.1 , AA501872.1 , AA468784.1, AA42645I.1, AA283005.1, AA133936.1, W32063.1, N64037.1, N51020.1, N40815.1, H63092.1, R49657.1, Tl 6844.1 , AW370598.1 , AA659409.1 , AA 186898.1 , H39920.1 , R72342.1 , T93314.1 , A W081941.1 , AA989349.1 , AA470559.1, AA457651.1, AA161492.1, AI094108.1, AA857601.1, AA662926.1, AA527286.1, N59569.1, N29751.1, F02740.1, AW008651.1, AW007933.1, AA700038.1, AA639250.1, AA595520.1, AA401945.1, AA292700.1, AA285066.1, A W051429.1 , AWO 16442.1 , AI904811.1, AI249150.1 , AA766310.1 , AA635049.1 , AA506458.1 , AA281435.1 , R07361.1, AI391736.1, AA748722.1, AA486063.1, N50735.1, H68177.1, AW504900.1, AW293621.1, AW274925.1, AW081375.1, AI990487.I, AI978583.1, AI950451.1, AI808248.1, AA595803.1, AA470087.1, AA459150.1, AA369383.1, W38454.1, W24925.1, R42480.1, R34154.I, F02835.1, F02756.1, T28100.1, AA508772.1, AA244026.1, W15152.1, F02836.1, AL157387.1, AC067940.2, AC010336.5, AC024700.3, U82213.1, AC053496.2, AC010553.4, AC012184.3, AC018557.4, ACOl 1655.4, AC007181.1, AL354932.4, AL137854.2, AC060826.2, AC068525.1, AC008533.5, AC021221.3, AC015845.4, AC022286.4, AC069250.1, AC069249.1, AC055839.2, AC027178.3, AC064834.2, AC026046.4, AC024584.4, AC020904.5, AC010649.5, AC010503.5, AC010311.7, AC010449.4, AC008828.3, AC021573.4, AC009244.20, ACOl 1523.2, ACOl 1516.2, ACOl 1495.3, AC010321.4, AC009107.6, AC068105.1, ACOl 1962.2, AC027095.2, AC026771.2, AC022470.4, AC016700.2, AC036198.1, AC034115.1, AC025958.2, AC018999.3, AC018389.3, ACOl 1853.3, AC015775.3, AC023043.2, AC018566.4, AC015726.3, AC025090.2, AC019220.2, AC023273.3, ACOl 1037.3, AC013648.3, AC023470.2, AC021154.3, AC018803.2, AC017052.4, AC016801.2, AC012548.3, AC022382.1, ACOl 1999.3, AC005096.1, AL356128.2, AL132867.12, AL160414.6, AL136108.3, AP000933.2, AC021026.4, AC023332.3, AC016739.2, AC026689.3, AC010602.4, AC016561.5, AC008477.4, ACOl 1559.2, AC026539.2, AC004906.2, AC041028.1, AC032039.1, ACOl 8579.4, AC023989.2, AC022596.3, AC007219.1, AC024305.1, AC015727.3, AC010148.4, AC018745.2, AC016164.1, AL354878.2, AL162272.3, AP001020.1, AC016923.7, AC023369.2

SEQ ID NO: 487

ZH1346/T3

AK000624.1, NC 001807.2, J01415.1, X93334.1, V00662.1, X62996.1, D38112.1, NC .001644.1, D38116.1, AJ270690.1, X93335.1, NC .001643.1, D38113.1, L00016.1, X93347.1, NC .001645.1, D38114.1, NC .002083.1, X97707.1,

NC .001646.1, D38115.1, Y17178.1, S80990.1, Z60371.1, NC .002082.1, X99256.1, X93345.1, X93344.1, V00672.1, Y17176.1, V00658.1, X89845.1, Y17173.1, Y17180.1, Y17172.1, U92964.1, V00675.1, U92965.1, U92962.1, U92963.1, U92967.1, U92961.1, U92969.1, U92953.1, U92952.1, U92958.1, U92968.1, U92954.1, U92960.1, U92959.1, U92957.1, U92970.1 , U92950.1 , NC 001992.1 , U92956.1 , Y 18001.1 , U92955.1 , U92951.1 , U92966.1 , Y 16707.1 , X91844.1 , X89767.1, X95677.1, V00659.1, NC_001325.1, AF053695.1, X63726.1, NC_001601.1, X72204.1, AF053696.1,

AF053697.1, U88283.1, AF053694.1, NC .000845.1, AF034253.1, AJ002189.1, NC .001567.1, U96639.2, J01394.1, NC .002008.1, V00654.1, D85282.1, NC .001788.1, X97337.1, NC .001779.1, NC .001700.1, U20753.1, X97336.1; NC .001794.1, Y10524.1, NC .001602.1, X72004.1, NCJMH808.1, NC .001640.1, Y07726.1, X79547.1, AC007283.3, AF053686.1 , D85291.1, L32587.1 , Al 133129.1 , Al 174835.1 , Al 114646.1 , AA583915.1 , AA837506.1 , AA828080.1 , AW476695.1, AA456337.1, AI174687.1, AA845434.1, AL038877.1, AA608740.1, AA658828.1, AA808070.1,

AI207408.1, AA984203.1, AA857455.1, AA773323.I, AI174794.1, AI133174.1, All 10847.1, AA176583.1, C18439.1, AA904301.1, AI814544.1, AL048271.1, AA856778.1, AA633895.1, AI174730.1, AA630140.1, AI557498.1, AA553443.1, AW772675.1, AA564555.1, AA507255.1, AA808161.1, AA661906.1, AA886828.1, AA176822.1, AL036895.3, AA209389.1, AI832559.1, AA805233.1, AI685974.1, AI208586.1, AI571104.1, C18291.1, AI133693.1, AL047524.1, AA595999.1, AA156220.1, AA595509.1, AA582810.1, AA516479.1, AH 14473.1, AI174817.1, AA650251.1,

AA209315.1, AI285116.1, AL047614.1, AI581393.1, AA180770.1, AA552811.1, AA226486.1, AI525583.1, AA639252.1, AA196849.1, AA679483.1, AA876588.1, AA736437.1, AW576921.1, AA532961.1, C 17039.1, AAl 94666.1, A A600750.1, AA689243.1, AA602775.1, AI557433.1, AA574219.1, AA548826.1, AA467942.1, AI969525.1, AW849013.1, AI718315.1, AW583904.1, AI628700.1, AA630233.1, AA548920.1, AA897055.1, AA575992.1, AA196582.1, AA729456.1, AA640698.1, AA577503.1, AA084473.1, AI041369.1, AA131048.1, AW516084.1, AA554459.1, AW607854.1, AC0219653, AC008670.3, AL161450.4, AC018856.3, AC013437.3, AC066616.2, AC025429.2, AC021755.4, ACOl 1821.4, AC013297.4, AC016052.2, AC022827.2, AC023374.2, AC022861.2, AC067925.1, AC021473.3, AC012363.1, AC021835.3, AC025395.2, AC007595.3, AC068981.1, AC021753.3, AC023652.3, AC016760.3, AL354751.2, AC009658.5, AC025916.2, AC012128.3, AC009907.2, AL138765.3, AL355177.1, AL355176.1, AC006393.6, AL133513.2, AC034300.2, AC024468.2, AC019324.3, AC007670.2, AC012433.5, AP001499.1, AC025643.3, AC002987.1, AL160052.3, AC022148.4, ACOl 1419.4, AC008586.4, AC026918.2, ACOl 1965.3, AC023387.2, AC009882.3, AC034206.1, AC013334.6, AC015948.3, AC018900.3, AF205591.1, AL355348.3, AL158831.5, AC002490.1, AL354696.1, AL160009.3, AL157712.2, AL353731.1, APOO 1205.1, AP000867.1, AP000424.1 SEQ ID NO: 488 ZH1346/T7

AK000624.1, NC_001807.2, J01415.1, X93334.1, V00662.1, X62996.1, D38112.1, AJ270690.1, LOOO 16.1, NC_001644.1, D38116.1, X93335.1, NC_001643.1, D38113.1, X93347.1, NC_001645.1, D38114.1, X93345.1, X93344.1, NC_001646.I, V00672.1, D38115.1, NC_002083.1, X97707.1, V00658.1, Y17176.1, S80990.1, V00675.1, Z60371.1, Y17173.1, X91844.1, Y17180.1, Y17172.1, Y17178.1, NC_002082.1, X99256.1, Y16707.1, X95677.1, U92950.1, U92964.1, U92965.1 , V00659.1 , X89767.1 , D85282.1 , U92969.1 , U92967.1 , M22651.1, U92954.1 , U92953.1 , U92952.1 , D85268.1 , U92968.1, M22650.1, D85271.1, AF053696.1, U92970.1, U92966.1, D85269.1, D85270.1, U88283.1, U92955.1, U92963.1, U92961.1, NC_001992.1, Y18001.1, AF053697.1, AF053695.1, AF053694.1, U88291.1, NC_001779.1, X97336.1, D85281.1, U88292.1, U92962.1, NC_001794.1, Y10524.1, NC_001788.1, X97337.1, D85284.1, NC_001808.1, Y07726.1, D85291.1, NC 001325.1, X63726.1, NC_001640.1, X79547.1, NC .001602.1, X72004.1, AJ002189.1, U88256.1, NC _.000845.1, AF034253.1, NC .000889.1, U88268.1, U88266.1, U88261.1, U88258.1, U88255.1, AJ010957.1, AF053686.1, AI174687.1, AA837506.1, AA608740.1, AI133174.1, AA857455.1, AA773323.1, AI110847.1, AI133129.1, AA904301.1, AA845434.1, AA828080.1, AA633895.1, AA808070.1, AA658828.1, AA808161.1, AL048271.1, AA805233.1, C18439.1, AA630140.1, AA507255.1, AI571104.1, AA156220.1, AL038877.1, AI174835.1, AA650251.1, AA553443.1, AA176822.1, AA736437.1, AA467942.1, AA456337.1, AA630233.1, AA897055.1, AI718315.1, AA577503.1, AA548340.1, AA689243.1, AI133039.1, AH 14646.1, AA575992.1, AA856778.1, AA602775.1, AA193235.1, AA757434.1, AA131048.1, AA075714.1, AA582747.1, AA595999.1, AA583915.1, AA196849.1, AA548826.1, AI557663.1, AA548207.1, AA582810.1, AA192336.1, AI557433.1, AI557309.1, AA889509.1 , AA554794.1 , AA143798.1, AA886828.1, AA614220.1, AA514865.1, AA554088.1, AA548920.1, AA548557.1, AA679483.1, AW867453.1, AA860683.1, AA563755.1, AL038831.2, AW867465.1, AA595385.1, AA402635.1, Cl 7039.1, AW849013.1, AI207408.1, AA514820.1, AA575938.1, AA477645.1, AA194768.1, AI920879.1, AA554459.1, AA404596.1 , AA487619.1 , AA613098.1 , AA574219.1 , AAl 94626.1 , AW867621.1 , AA757912.1 , AI581393.1 , AA564555.1, AI285116.1, AA876588.1, AA532961.1, AI735435.1, AA604312.1, AA486862.1, AW419471.1, AA582107.1, AA608573.1, AC021965.3, AC008670.3, AC025429.2, AC021755.4, ACOl 1821.4, AC013297.4, AC016052.2, AC022827.2, AC012363.1, AC007595.3, AC068981.1, AC023652.3, AC021753.3, AC067925.1, AC021473.3, AC018856.3, AC012128.3, AC013437.3, AL138765.3, AC023374.2, AC022861.2, AC066616.2, AC025395.2, AC021835.3, AL161450.4, AL355177.1, AL355176.1, AC006393.6, AC016760.3, AL354751.2, AL133513.2, AC012433.5, AP001499.1, AC034300.2, AC019324.3, AC007670.2, AC002987.1, AL160052.3, AC025643.3, AC022148.4, ACOl 1419.4, AC008586.4, AC026918.2, AC060234.2, ACOl 1965.3, AC035139.3, AC023387.2, AC009882.3, AC034206.1, AC015948.3, AF205591.1, AC005848.1, AL158831.5, AC002490.1, AL354696.1, AL160009.3, AL157712.2, AL138690.3, AP001453.1, AP001205.1, AP000867.1, AP000573.2

SEQ ID NO: 489 G PROTIEN PATHWAY SUPPRESSOR 1 (gpsl)

NM_004127.2, U20285.2, X87885.1, AE003519.1, AF129080.1, AL133469.1, X86780.1, AC002059.3, AC000026.3, NM_001127.1, L13939.1, U36256.1, AE003486.1, AC016795.4, U48889.1, AC020626.6, AE003571.1, AE003463.1, AF162681.1, AC005342.1, U66722.1, AF029395.1, ALl 10479.1, AJ242980.1, U40726.1, U40725.1, U40724.1, U40723.1, U40721.1, S71660.1, AJ243806.1, U71124.1, Z92530.1, Y09870.1, AA315980.1, AL046753.1, AA308668.1, AA776140.1, AW379968.1, AW379969.1, AA794667.1, AW401492.1, R22366.1, AW250694.1, AI195918.1, AW250541.1, R33383.1, Z44978.1, Z45804.1, AA627685.1, AA972517.1, AW414640.1, AW379955.1, H12155.1, AA492726.1, AW748739.1, AA337940.1, W65922.1, R73336.1, AW660352.1, AA870416.1, AF031560.1, AA170086.1, AW491649.1, AA026010.1, AW806517.1, AA065408.1, R75578.1, AA109188.1, AA368286.1, AA688596.1, AW674959.1, AA051022.1, AA330082.1, AW248164.1, AA302223.1, C83545.1, C82689.1, W17566.1, AW423128.1, W69617.1, AA865730.1, AA445357.1, AA279618.1, H32851.1, AI958622.1, AW462925.1, AW175196.1, W09671.1, AA979613.1, AW147429.1, AI035492.1, AA166156.1, AA062100.1, AI496702.1, AW213099.1, AA815807.1, AA210626.1, W89993.1, AA517695.1, AI194303.1, AW357953.1, AI693878.1, AI617037.1, AI258459.1, AI525953.1, AI979966.1, AC015708.3, AL353692.3, AC015160.1, AC020611.4, AC026114.6, AC020879.2, AC016919.5, AC026832.2, AC068451.1, AC063964.1, AC024460.2, AC025553.2, AC024258.1, AC017158.1, AL356245.1, AC016932.4, AC055706.3, AC069027.3, AC068583.1, AC026953.2, AC053468.1, AC023414.2, AC037432.1, AC007643.2, AC020690.4, AC019163.3, AC018804.2, AC010884.4, AC020509.1, AC014559.1, AC004630.2, AL353719.3, AL158037.6, AL138875.3, AL356100.1, AL157404.2, AL161897.3, AL162311.1, AL157757.1, Z98855.1, AP001372.1, AP001095.2

SEQ ID NO: 490 ZH057/T3

NM_004127.2, U20285.2, X87885.1, AE003519.1, AF129080.1, AL133469.1, X86780.1, AC002059.3, AC000026.3, NM_001127.1, L13939.1, U36256.1, AC016795.4, U48889.1, AC020626.6, AE003463.1, U66722.1, AF029395.1, AJ242980.1, AJ243806.1, U71124.1, AL046753.1, AW379968.1, AW379969.1, AW401492.1, AW250694.1, AA776140.1, Z44978.1, AA315980.1, Z45804.1, AA627685.1, AW379955.1, H12155.1, AI195918.1, AA337940.1, AA794667.1, W65922.1, AW660352.1, AA308668.1, AA870416.1, AA170086.1, AA026010.1, R33383.1, AW806517.1, AA065408.1, AW491649.1, R22366.1, AF031560.1, AA688596.1, AW674959.1 , AA330082.1 , AW248164.1, AA368286.1, C83545.1, C82689.1, AW423128.1, W69617.1, AA492726.1, H32851.1, AI958622.1, AW462925.1, R75578.1, AW175196.1, AW414640.1, AA979613.1, AA166156.1, AI496702.1, AA815807.1, AA210626.1, AI194303.1, AW357953.1, AI258459.1, AW584802.1, AW584801.1, AI979966.1, AI073824.1, AW459926.1, AA566237.1, D26329.1, AW680375.1, AI855245.1, AI855218.1, AI855212.1, AI734700.1, AA524064.1, W59814.1, W29472.1, AC015708.3, AL353692.3, AC015160.1, AC020879.2, AC016919.5, AC026832.2, AC068451.1, AL356245.1, AC055706.3, AC027568.2, AC024190.2, AC007643.2, AC018804.2, AC020509.1, AC004630.2, AL353719.3, AL158037.6, AL138875.3, AL356100.1, AL157404.2, AL161897.3, AL162311.1, AL157757.1 SEQ ID NO: 491 ZH057/T7

U20285.2, NM_004127.2, X87885.1 , J05517.1 , NM_007438.1 , ALl 33445.2, X03797.1 , Y00516.1 , ACOl 0510.6, AC007314.3, AL136059.2, AL031780.1, Z16710.1, AF 144093.1, AC006449.19, AF034136.1, AF064749.1, AL163238.2, AL137716.1, AL031721.1, Z98257.1, AL078630.1, M36535.1, M17843.1, AP001693.1, AP001340.1, D00451.1,

D00185.1, D00361.1, AI056387.1, AA573934.1, AW247126.1, AI669053.1, AW167515.1, AI685726.1, AI479985.1, AI859762.1 , AW732050.1 , AI567797.1 , AA595162.1 , AI458542.1 , AI377236.1 , AA604679.1 , AI961737.1 , AI951858.1 , AI743281.1, AI202810.1, AI139695.1, AI564292.1, AA662524.1, AI813703.1, AI131335.1, AA583446.1, AA807224.I, AI492268.1, AI299166.1, AI272746.1, AA994505.1, AA988395.1, AA521025.1, AW246831.1, AI799551.1, AI952561.1, AI521316.1, AA569807.1, AA716051.1, AA580208.1, AA988396.1, AI810703.1, AA994504.1, AA969251.1, AI928074.1, AA657992.1, AA931856.1, AI091930.1, AA847278.1, AWl 88344.1, AI796670.1, AA749404.1, AI272794.1, F24930.1, AI471309.1, AI825867.1, F24931.1, AA757891.1, AA708597.1, AA974663.1, AA732155.1, AI240890.1, AI885726.1, AI638230.1, AI871463.1, AA766100.1, AI090239.1, AW249881.1, AA280965.1, AI808546.1, AA434157.1, AI285895.1, AW474426.1, AW189219.1, AA913078.1, AW674940.1, AW300960.1, AI868353.1, AI470209.1 , AA923622.1 , AW166880.1, F25087.1, AA481945.1, W79901.1, R73316.1, AW513345.1, AW592528.1, AI818261.1, AI870480.1,

AI354982.1 , AW591711.1, AI934744.1 , AI458656.1 , A W073126.1 , AI925790.1 , AI360724.1 , AA309009.1 , AW304052.1 , AA993663.1, AW651615.1, AA862926.1, AW316592.1, AC015708.3, AL353692.3, AC023254.3, AL355837.1, AC010180.4, AC048382.2, AC037456.4, AC009477.3, AC025698.3, AC022922.2, AC023091.2, AC015784.2, AC020645.2, AL355365.2, AL161437.5, AL133261.5, AL136147.2, AP001766.1, AC068800.3, AC067739.3, AC025154.4, AC023276.3, AC068679.1, AC044792.2, AC040159.2, ACOl 1352.3, ACOl 1402.5, AC008615.4, ACOl 1499.2, AC027622.3, AC026657.3, AC027098.2, AC040950.1, AC021152.3, AC015960.4, AC018435.3, AC025684.2, AC022190.3, AC022050.2, AC025361.2, ACOl 1032.3, AC021534.3, AC025834.1, ACOl 1224.5, AC024333.2, AC018580.4, AC024628.2, AC017108.2, AC015864.1, AC010136.3, AC016811.2, AC009798.2, AC004676.1, AL139420.2, AL157902.2, AL139119.5, AL121759.19, AL139004.3, AL355514.I, AL353801.2, AL161900.3, AL158172.1, AP001501.1, AP001499.1

SEQ ID NO: 492

ZH1276 T3

NM_004127.2, U20285.2, X87885.1, AE003519.1, AF129080.1, ALl 33469.1, X86780.1, AC002059.3, AC000026.3, NM_001127.1, L13939.1, U36256.1, AC016795.4, U48889.1, AC020626.6, AE003539.1, AE003486.1, AE003463.1, U66722.1, AF029395.1, AJ242980.1, AJ243806.1, U71124.1, AL046753.1, AA315980.1, AA776140.1, AA308668.1, AI195918.1, AW379968.1, AA794667.1, AW379969.1, AW401492.1, Z44978.1, AA627685.1, R33383.1, R22366.1, AW250694.1, AA337940.1, Z45804.1, W65922.1, AW379955.1, HI 2155.1, AA492726.1, AF031560.1, AW491649.1, AA026010.1, AW414640.1, AW250541.1, AA972517.1, R75578.1, AW660352.1, AA870416.1, AA065408.1, AAl 70086.1 , AA368286.1 , AW423128.1 , A W748739.1 , AA051022.1 , AI958622.1 , AA688596.1 , AW674959.1 , AW175196.1, AA330082.1, R73336.1, AW806517.1, W69617.1, C83545.1, C82689.1, AA979613.1, H32851.1, AI496702.1, AA210626.1, AA109188.1, AA517695.1, W17566.1, AW248164.1, AI194303.1, AW462925.1, AI617037.1, AI258459.1, AW584802.1, AW584801.1, AI073824.1, AA166156.1, AW459926.1, AA566237.1, D26329.1, AW680375.I, AW527841.1 , AI855245.1 , AI855218.1 , AI855212.1 , AI734700.1 , AI404003.1 , AA524064.1 , AA251639.1 , W59814.1 , W29472.1, AC015708.3, AL353692.3, AC015160.1, AC020879.2, AC016919.5, AC026832.2, AC020611.4, AC026114.6, AL356245.1, AC055706.3, AC036180.2, AC069027.3, AC026689.3, ACOl 1558.4, AC026953.2, AC037432.1, AC007643.2, AC021558.3, AC010884.4, AC020509.1, ACOl 7158.1, AC017776.1, AF207954.1, AC004630.2, AL353719.3, AL356100.1, AL161897.3, AL162311.1, AL157757.1, AP001095.2 SEQ ID NO: 493 ZH176/T3

NM_004127.2, U20285.2, X87885.1, AE003519.1, AF129080.1, AL133469.1, AC002059.3, AC000026.3, NM_001127.1, L13939.1, U36256.1, X86780.1, AE003486.1, AC016795.4, U48889.1, AC020626.6, AE003571.1, AF162681.1, AC005342.1, U66722.1, ALl 10479.1, AJ242980.1, U40726.1, U40725.1, U40724.1, U40723.1, U40721.1, S71660.1, AJ243806.1, Z92530.1, Y09870.1, AA315980.1, AA308668.1, AL046753.1, AA776140.1, AA794667.1, R22366.1, AI195918.1, AW250541.1, R33383.1, AA9725I7.1, AA627685.1, AW414640.1, AW379968.1, AW748739.1, AA337940.1, AW379969.1, AW401492.1, AA492726.1, Z44978.1, R73336.1, AW250694.1, W65922.1, AA026010.1, AF031560.1, Z45804.1, AW491649.1, AA109188.1, AW379955.1, H12155.1, R75578.1, AA051022.1, AA302223.1, AW660352.1, AA065408.1, AA368286.1, W17566.1, AA870416.1, AW423128.1, AA170086.1, AA865730.1, AA445357.1, AA279618.1, AI958622.1, AW175196.I, W09671.1, AA979613.1, AW147429.1, AI035492.1, AA688596.1, AA062100.1, AI496702.1, AW213099.1, AA210626.1, W89993.1, C83545.1, C82689.1, AA517695.1, AW674959.1, AI194303.1, AI693878.1, AI617037.1, AI258459.1, AA330082.1, AI525953.1, AC015708.3, AL353692.3, AC015160.1, AC020611.4, AC026114.6, AC020879.2, AC016919.5, AC026832.2, AC063964.1, AC024460.2, AC025553.2, AC024258.1, AC017158.1, AL356245.1, AC016932.4, AC055706.3, AC069027.3, AC068583.1, AC026953.2, AC053468.1, AC023414.2, AC037432.1, AC007643.2, AC020690.4, AC019163.3, AC010884.4, AC014559.1, AL353719.3, AL356100.1, AL161897.3, AL1623I 1.1, AL157757.1, Z98855.1, AP001372.1, AP001095.2

SEQ ID NO: 494 ZH176/T7 U20285.2, NM_004127.2, X87885.1 , J05517.1, NM_007438.1, AL133445.2, X03797.1, Y00516.1, AC010510.6, AC007314.3, AL136059.2, AL031780.1, Z16710.1, AF144093.1 , AC006449.19, AL032626.1 , AL137716.1, AL031721.1, Z98257.1, AL078630.1, M36535.1, M17843.1 , D00451.1 , D00185.1, D00361.1, AI056387.1, AI567797.1 , AI139695.1, AW247126.1 , AI669053.1 , AI685726.1 , AI272746.1 , AI202810.1 , Al 131335.1 , AW732050.1 , AI743281.1 , AWl 67515.1 , AI458542.1, AI859762.1, AI377236.1, AW246831.1, AI492268.1, AI479985.1, AI952561.1 , AA595162.1 , AA573934.1, AI299166.1, AA662524.1, AI951858.1, AA994505.1, AA988396.1, AA604679.1, AA988395.1, AA716051.1, AA580208.1 , AA994504.1 , AA583446.1, AI799551.1, AI564292.1, AA521025.1, AA569807.1, AI928074.1, AI813703.1, AA969251.1, AA931856.1, AA657992.1, AI272794.1, AI796670.1, AI091930.1, AA749404.1 , AI810703.1, F24930.1, AA847278.1 , AWl 88344.1 , AI825867.1 , F24931.1, AI521316.1 , AI471309.1 , AA708597.1 , AI961737.1 , AA757891.1, AA732155.1 , AA807224.1 , AI240890.1, AA974663.1, AI885726.1 , AI638230.1, AI871463.1, AA766100.1, AI090239.1, AW249881.1, AI808546.1, AA434157.1, AI285895.1, AW474426.1, AWl 89219.1, AW674940.1 , AW300960.1 , AI868353.1, AI470209.1, AA923622.1, AW166880.1, F25087.1, AA913078.1, AA481945.1, AW513345.1 , AW592528.1, AI818261.1 , AI870480.1 , AI354982.1 , A W59171 1.1 , AI934744.1 , AI458656.1 , AW073126.1 , AI925790.1 , AI360724.1 , AW304052.1, AA993663.1, AW651615.1, AI864783.1, AA862926.1, AW316592.1, AI270639.I, Z41443.1, AA482068.1

SEQ ID NO:495

ZH183/T3

NM_004127.2, U20285.2, X87885.1, AE003519.1 , AF129080.1, AL133469.1, AC002059.3, AC000026.3, NM_001 127.1,

L13939.1, U36256.1, X86780.1, AE003486.1, AC016795.4, U48889.1, AC020626.6, AE003571.1, AE003532.1, AF208486.1, NM_000377.1, AF196970.1, AF162681.1, AFl 15549.2, AC005543.2, AC005342.1, U66722.1, U19927.1 , AC005194.1 , AF067616.1 , ALl 10479.1 , AJ242980.1 , U40726.1 , U40725.1 , U40724.1 , U40723.1 , U40721.1 , S71660.1 , AJ243806.1 , Z92530.1, U12707.1, Y09870.1, AA315980.1, AA308668.1, AL046753.1, AA776140.1 , AA794667.1, R22366.1 , AI195918.1, R33383.1 , AW25054I .1, AA627685.1, AW379968.1, AA972517.1, AA337940.1, AW414640.1, AW379969.1, AW401492.1, Z44978.1, AW748739.1, AA492726.1, AW250694.1 , R73336.1, W65922.1 , AA026010.1, AF031560.1 , Z45804.1, AW491649.1, AW379955.1, H12155.1, R75578.1, AA109188.1, AA051022.1, AW660352.1,

AA065408.1, AA368286.1, AA870416.1, AW423128.1, Wl 7566.1 , AAl 70086.1, AA302223.1, AI958622.1, AA445357.1, AW175196.1, AA865730.1, AA279618.1, W09671.1, AA979613.1, AA688596.1, AI496702.1, AA210626.1, AI035492.1, AA062100.1, C83545.1, C82689.1, AW147429.1, AA517695.1 , AW213099.1 , W89993.1, AW674959.1, AI194303.1, AI258459.1, AI617037.1, AA330082.1, AW584802.1, AW584801.1, AI073824.1, AA390628.1, AW459926.1 , AI404003.1 , AA566237.1, W69617.1 , D26329.1, AW680375.1 , AW401800.1, AW261771.1, AV371344.1, AV370592.1, AI855245.1, AI855218.1, AI855212.1, AI734700.1, AU057766.1, AI558068.1, AI515797.1, AI455890.1 , A A817166.1, C73394.1 , AA539163.1, AA524064.1 , AAI41792.1, W59814.1, W29472.1, U37979.1, H04932.1, D48939.1, D48247.1, AC015708.3, AL353692.3, AC015160.1, AC020611.4, AC026114.6, AC020879.2, AC016919.5, AC026832.2, AC025553.2, AC021978.4, ACOl 1241.3, AC017158.1, AL356245.1, AC055706.3, AC015970.4, AC069027.3, ACOl 1353.3, AC026953.2, AC053468.1, AC037432.1, AC019008.4, ACOl 1944.3, AC007643.2, AC010060.7, AC010884.4, AC019802.1, AC014559.1, AC006741.2, AL353719.3, AL356100.1, AL139191.3, AL161897.3, AL1623U .1, AL157757.1, Z98855.1, AP001095.2

SEQ ID NO:496 Liprins, Tyrosine Phosphatase-Interacting Protein

NM_003625.1 , AF034799.1, NM_003626.1, U22816.1, U22815.1, L16840.1, AB014554.1, AC006695.1, AF053008.1, Z68218.1, L06326.1, AC008526.5, AC004805.1, Z50794.1, Z49066.1 , U49510.1, AC025808.8, AC010494.4, AC008940.3, AC024609.2, AF224669.1, AC008069.3, AF170122.1, AF180335.1, AF079271.1, AF104919.1, AC005855.1 , AC003684.1, AC004102.1, AC003997.1, AL049555.6, AL132776.11, AL161492.2, AL133012.1, AL023534.1, Z75747.1, AL031313.1, Z83827.1, AL022152.1, AB009048.1, AW046469.1, AL040578.2, AL040560.2, AA405311.1, AWl 63189.1 , AV216286.1, AV098238.1, AI586144.1, R18931.1, AW739485.1, AW651017.1, AW648174.1, AW513939.1, AW355770.1, AW279529.1, AW276572.1, AV383282.1, AI972830.1 , AI851698.1, AI851697.1, AI831899.1, AI539950.1, AI268862.1, AI205406.1, AH 10543.1, AU012446.1, AI066756.1, AI027679.1, AA967290.1, AA877239.1, AA776237.1 , AA689301.1, AA630746.1, AA405312.1, AA294505.1, C16133.1, N65637.1, D79793.1, D70186.1, H95071.1, H88097.1, R98374.1, R17683.1, ACOl 1316.8, AC069228.1 , AC025413.2, APOO 1787.1 , AP000487.2, AC008687.3, AC022764.3, AC022788.2, AC006740.2, AL139045.7, AC020649.4, AC069216.1, AC012604.3, AC017043.3, AC021 122.3, AC020715.2

SEQ ID NO:497 ZH1213/T3 NM_003625.1, AF034799.1 , NM_003626.1 , U22816.1, U22815.1, AC006695.1, AF053008.1 , L06326.1, Z49066.1, L05915.1 , M64268.1 , X58390.1, AC025808.8, AC010494.4, AC024609.2, AF224669.1, AC007450.1, AF079271.1, AF104919.1, AF078802.1, AC003684.1, AL132776.1 1 , AL161492.2, AL133012.1, U81831.1, Z75747.1, Z83827.1, AL022152.1, AJ248283.1, AB009048.1, AW046469.1, AW163189.1 , A V216286.1, AV098238.1, AW651017.1 , AW648174.1, AV383282.1, R98374.1 , ACOl 1316.8, AP001787.1, AP000487.2, AC022764.3, AC006740.2, AL139045.7, AC017043.3, AC021122.3, AC020715.2, AC008180.9, AC024898.7, AC024238.2, AC010307.4, ACOl 1369.3, AC068460.1, AC024636.3, AC034191.2, ACOl 8797.3, AC027224.2, AC027631.2, AC026377.2, ACOl 9252.3, AC016363.3, AC026073.2, AC025527.2, AC021 114.3, AC018954.4, AC021718.3, AC024629.1, AC016448.3, AC023483.2, AF153342.2, AC005961.1, AL355143.4, AL121876.27, AL138921.6, AL138741.3, AL353599.5, AL158197.6, AL022167.1, AP002018.1, AP001006.1 SEQ ID NO: 498 ZH1213/T7

AK000348.1, NC_001807.2, J01415.1, X93334.1, V00710.1, V00662.1, X62996.1, D38112.1, D50525.1, AB004064.1, NC .001643.1, D381 13.1, X93335.1, NC .001644.1, D38116.1, X99189.1, NC_001645.1, D38114.1, X93347.1 ,

NC .002083.1, X97707.1, NC .001646.1, D38115.1 , NC_002082.1, X99256.1 , AF058292.1, AF176066.1, AF004338.1, Z54552.1, Z54553.1, Z60381.1, U63507.1, U63506.1, U63505.1, U63486.1, NC_001992.1, Y18001.1 , Z62861.1, Z62860.1, U63488.1 , U63487.1 , Z62093.1, Z57443.1, M86498.1, NC_001567.1, J01394.1, U39004.1, V00654.1, AB033608.1, Z65548.1, NC_001700.1 , U20753.1, S75063.1, M86495.1 , NC .001601.1, NC_001321.1, X72204.1, X61145.1, M86501.1, NC_001941.1, AF010406.1₎ M86499.1, M35875.1, NC_001779.1, X97336.1, AJ010814.1, M55539.1 , AJ010816.1 , AJ010815.1, NC_001808.1, M35877.1, Y07726.1, AF203744.1, M86497.1, AF203774.1, AF203727.1, U97337.2, NC_001913.1 , AF203741.1, AJ001588.1, M55541.1, NC_002391.1, AF203743.1, Y19192.1, AF203742.1, AF069538.1, M86493.1, U97336.2, AF069537.1, AB032843.1, AB032842.1, AF179288.1, M55540.1, U97339.2, U97343.1, AFl 79290.1, AF203726.1, AJ010812.1, AF069533.1, AJ245896.1, AW603665.1, AI061586.1, AL047741.1, AI133246.1, AW601774.1, AI061658.1, AI110678.1 , AW849003.1 , AW848377.1, AW848797.1,

AW868260.1 , AW848724.1 , AW848653.1 , AW848366.1 , AI499067.1 , AW848373.1 , AW848226.1 , AW848180.1 , AW607912.1 , AW837520.1 , AW835394.1 , AW848445.1, AW848175.1, AW867448.1, AW848368.1, All 14451.1, AW848376.1, AW835382.1, AW161643.1, AW837509.1, AW578366.1, AA219735.1 , AW867405.1 , AW578361.1, AL037474.2, AW842623.1, AW157026.1, AI983822.1, AA196173.1, AA099002.1, AA469432.1, AW867402.1 , AW578374.1, AA088843.1, AI525751.1, AW848920.1, AW607758.1 , AW058235.1, AW837514.1, AI057519.1,

AA814643.1, AA220989.1, AI961435.1, AI525710.1, AA100034.1, AW601494.1, AW842070.1, AI955201.1, AI889478.1, AW168799.1 , AW864632.1 , AI133661.1 , AA574454.1, AA083209.1, AA776938.1, AW835463.1, AI921008.1, AI192705.1, Z98526.1, AA179899.1, AI683759.1, AW578372.1, AI983554.1 , AI983243.1, AI683947.1 , AI525757.1, AA467764.1, AW801146.1, AA225870.1, AW577755.1, AI557286.1, AA223928.1, AW604355.1, AI954959.1, AW602132.1, AW074139.1, AI687413.1, AW839594.1, AI922568.1, AA668465.1 , AW607161.1, AI961417.1,

AI858348.1, AI814152.1, AI444594.1, AW848995.1, AA468311.1, AI829389.1, AA747096.1, AA469385.1, AC068619.1, AC021914.3, AL158819.2, AL135939.9, AC015935.4, AC022317.4, AC067925.1, AC021473.3, AL161450.4, AC025380.2, AC012365.3, AC018441.3, AC027019.2, AC021451.2, AC021835.3, AC024498.2, AC025283.1, AL356135.2, AL353646.1, AC023928.3, AF182108.1 , AL139000.2, AC025337.1, AC024248.3, ACOl 1954.5, ACOl 1025.4, AP001947.1, AL121927.18, AC007400.2, AC025936.2, AC058808.1, AC051663.4, AC025731.7, AL354955.1 , AC024033.2, AC027175.2, AC010270.4, AC068621.1, AC009796.3, AC027008.2, AL158207.3, ACOl 1821.4, AC013297.4, AC016052.2, AC026968.2, AL353147.3, AC018463.4, AC027413.2, AC026993.2, AC024953.3, AC019304.3, AC026519.1, AC022206.2, AL109955.13, AP001026.1, AP000919.2, AC019074.3, AC053543.3, AC026743.3, AC010496.4, AC027496.2, AC005140.6, AF202964.1 , AC005139.3, AL158067.5, AL355432.1

SEQ ID NO: 499

H1292/T3

,NM_003625.1, AF034799.1 , NM_003626.1 , U22816.1, U22815.1, L16840.1, AB014554.1, AC006695.1, AF053008.1,

Z68218.1, L06326.1, AC008526.5, AC004805.1, Z50794.1, U49510.1, AC025808.8, AC010494.4, AC008940.3, AC024609.2, AF224669.1, AC008069.3, AF170122.1, AF180335.1, AF079271.1, AF104919.1, AC005855.1, AC003684.1, AC004102.1, AC003997.1, AL161492.2, AL023534.1, AL049555.6, AL132776.11, AL031313.1, Z83827.1, AB009048.1, AW046469.1, AL040578.2, AL040560.2, AA405311.1, AW163189.1, AW906518.1, AW906447.1, AV216286.1 , AV098238.1, AI586144.1, R18931.1, AW739485.1 , AW513939.1, AW355770.1, AW279529.1, AW276572.1, AV383282.1, AI972830.1, AI851698.1, AI851697.1, AI831899.1 , AI539950.1 , AI268862.1, AI205406.1, AH 10543.1, AU012446.1, AI066756.1, AI027679.1, AA967290.1, AA877239.1, AA776237.1, AA689301.1, AA630746.1,

AA405312.1, AA294505.1, C16133.1, N65637.1, D79793.1, D70186.1, H95071.1, H88097.1, R17683.1, ACOl 1316.8, AC069228.1, AC025413.2, AP001787.1, AP000487.2, AC008687.3, AC022764.3, AC022788.2, AC006740.2, AL139045.7, AC069216.2, AC069259.1, AC020649.4, AC012604.3, AC017043.3, AC021122.3, AC020715.2, AC026250.4, AC024898.9, AC008180.9, AC053478.2, AC024238.2, AC010307.4, AC068460.1, AC024636.3, AC034191.2, AC018797.3, AC009612.3, AC025988.2, AC021878.2, AC018954.4, AC021010.3, AC024655.1 , AC022911.2, AC023483.2, AC016043.3, ACOl 1290.2, AC005961.1, AL355143.4, AL353599.5, AL158197.6, AP002018.1. AP001865.1,

SEQ ID NO: 500 ZH1292 T7

AL109985.2, AL031662.25, AL163282.2, AL031848.11, AC006323.3, AC008033.8, AC009230.3, ACOl 1310.3, AC010072.5, AC000353.27, AF217796.1, AC004130.1, AC004990.1, AC008062.2, AC004987.2, AC006213.1, AF001549.1, AC004638.1, AF042090.1 , ALl 57756.2, AF003627.1, AL133399.1, AL031224.1, AL031542.1, AC000052.16, AC004019.20, AC004417.1, AC010170.3, AC007957.35, AC023490.5, AC025588.1, AC000159.6, AC004875.1, AC006006.2, AC002492.1, AC005701.1, AC005523.1, AF064863.1, U63721.1, AC002402.1, AL021808.1, AL163262.2, AL137039.1, AL133387.8, AL035697.19, AL008582.11, AP001717.1, AP001410.1, AP000191.1, AP000159.1, AP000047.1, D87009.1, AP000556.2, APOOOl 15.1 , AC004890.2, AC002310.1, AC020629.6, AL163215.2, Z93023.1, AP001670.1 , AC008039.1 , AC016025.12, AC010722.2, AC009079.4, AC006111.2, AC006012.2, AC005019.1, AC007387.3, AC005057.2, AC005660.3, AF039907.1, AC006544.19, AC006543.7, AC005901.1, AC005962.1, AC005755.1, AL136000.2, AL163223.2, AL135744.2, AL049776.3, AL021937.1, AL031 178.1, AL035249.6, U62293.1, AP001678.1, AP001256.2, AC005072.2, AF006752.1 , AL023575.1 , AC009303.2, AC00651 1.5, AL163230.2, AP001685.1, AC000004.1, AC007030.3, AC004821.2, AC004234.1, AJ239318.3, AC008109.6, AC005565.1 , AA553710.1, R72458.1, AI471543.1, F36273.1, AI284640.1 , AI610159.1 , AI471481.1, AI334443.1, AI053672.1, AA542991.1, AW673241.1, AA825357.1 , AA810370.1 , AA350859.1 , N25296.1 , AW769399.1 , A W51 1743.1 , AW419262.1 , AW276827.1 ,

AW193432.1, AW193265.1, AI963720.1, AL046409.1, AI688846.1, AI613280.1, AI431303.1, AI35021 1.1, AI341664.1, AI061334.1, AL046457.1, AI281697.1, AW338086.1, AI358343.1, T07451.1, AW731867.1, AW504326.1, AW166815.1, AW162049.1, AL120483.1, AW029038.1, AI962050.1, AI929531.1, AI904894.1, AI890923.1, AF150222.1, AI375710.1, AI281881.1, AI133164.1, AA649642.1, AA535661.1, AA134367.1, AF150152.1, AA771811.1 , AA491814.1, AW276817.1, AI339850.1, AI251002.1, AA191620.1, AW833903.1, AW576391.1, AW517377.1, AW303876.1,

AI887483.1, AI287651.1, AA664015.1, AA599920.1 , AA533725.1, AA525876.1, W79504.1, AW600804.1, AL038785.1 , AI679782.1, AI567674.1, AI168185.1, AI133636.1, AA747472.1, AA630030.1, AA084070.1 , N55273.1, AW339568.1, AW303196.1, AW301350.1, AW274349.1 , AA581903.1, N71930.1, AW833898.1, AI358571.1, AW265385.1 , ALl 19691.1 , AI830390.1 , AI298710.1 , AA970213.1, AA280632.1 , AWl 04748.1 , AI251436.1 , AA515224.1 , AA364429.1 , AI160117.1, AI537955.1, AW474299.1, AL157387.1, AC022931.3, AC008443.4, AC021879.3, AC021401.4, AL161615.2, AC005973.4, AC026331.3, AC025175.2, AC009122.5, AC023359.6, AC025699.4, AC035141.2, AC034222.2, AC026442.2, AC020893.4, ACOl 1670.4, AC018637.1, AC012042.9, AC009228.3, AC044801.1, AC025564.3, AC025829.2, AC021160.3, AC016891.3, AC021957.3, AC021777.3, AC027283.1, ACOl 1768.4, AC025054.2, AC024437.2, AC013648.3, AC013768.4, ACOl 1844.3, AC022989.2, AC022845.2, AC023516.1, AC017078.3, AC013733.3, AC012410.2, AC013262.3, AC010165.2, AL049537.36, AL353715.3, AL138703.2, AL136223.3, AL157372.6, AL355521.1, AL160275.2, AP000631.3, AC019222.3, AL354723.1, AC055879.2, AC008622.4, AC016555.4, AC0341 19.1, AC022626.3, AL136221.8, AC064821.2, AC046165.2, AC053540.2, ACOl 1511.4, AC009040.4, AC027709.2, AC027096.2, AC008531.2, ACOl 1430.4, AC025935.2, AC012141.2, AC021037.4, AC019327.4, AC018573.2, AC015758.3, AC021661.1 , AC007163.2, AL109965.22, AL354935.3, AC010095.3, ACOl 1490.4, AC021634.4, AL355515.2, AL158081.1, AC009245.8, AC068364.1, AC005047.2, AC023133.2, AC026141.2, AC012662.5, AC009417.2, ACOl 1840.3, AC023988.2, AC007799.4, AC016978.2, AC005910.4, AF129075.1, AP000931.2, AC010649.5, AC021805.3, AC009070.5, AL121752.7

SEQ ID NO: 501 ZH1303/T3

NM_003625.1, AF034799.1, NM_003626.1, U22816.1, U22815.1, L16840.1, AC006695.1, AF053008.1, L06326.1, Z49066.1, AC025808.8, AC010494.4, AC007267.4, AC012262.14, AC024609.2, AF224669.1 , AC005013.1 , AF079271.1, AF104919.1, AC005194.1, AC003684.1, Z72001.1, AL132776.11 , AJ276674.1, AL161492.2, Z75747.1, Z70049.1, AL034428.1 , Z83827.1, AL022152.1, AL033388.1, AB009048.1, AW046469.1, AW163189.1 , AV216286.1 , AV098238.1, AW534545.1, AV383282.1, AA819367.1, AA945965.1, W67890.1, ACOl 1316.8, AC069228.1, AP001787.1, AP000487.2, AC022764.3, AC046202.2, AC022788.2, AC006740.2, AL139045.7, AP001989.1, AP001912.1, AC017043.3, AC021122.3, AC022911.2, AC020715.2, AC068908.2, AC008180.9, AC024898.7, AC023358.5, AC068909.3, AC024238.2, AC010290.6, ACOl 1369.3, AC027784.2, AC068460.1, AC026918.2, AC024636.3, AC068338.1, AC034191.2, AC018797.3, AC027224.2, AC019252.3, AC034183.1, AC026073.2, AC025527.2, AC021 1 15.3, AC018954.4, AC018911.4, AC023120.3, ACOl 1678.4, AC024629.1, AC018927.3, AC023483.2, AF153342.2, AC005961.1, AL355143.4, AL136523.3, AL121876.27, AL353599.5, AL135938.7, AL162418.2, AL158197.6, AL139085.1, AL022167.1, AP002018.1, AP001006. I

SEQ ID NO: 502 ZH1303/T7

NM_003625.1 , AF034799.1, NM_003626.1, U22816.1, U22815.1, AE0036I4.1 , AC003052.1, AB014554.1, AF034801.1, AF034800.1, AE003420.1, AL049595.5, AL031 128.1 , X95296.1, NM_014786.1, AC007187.4, AE003804.1 , AC002075.1, AC008171.2, AC007682.2, AC007967.3, AF147264.1, AC007015.I , AC005670.1, AC002326.1, AL096678.8, AL161506.2, Y12377.1, AL121774.3, AL138657.1, AL034546.5, AL109618.1 , AL022165.1, AL009031.1, AB020484.1, AB002335.1, AA325780.1, AV280945.1, AA393329.1 , AW675288.1, AW295112.1, AW440279.1, AI266228.1,

AI263426.1 , AA907742.1 , AA034766.1 , AW315478.1 , AA545569.1 , AW200169.1 , R85656.1 , AI354381.1 , N99720.1 , ALl 19228.1 , AI124575.1. H83858.1, AW218738.1, AW218737.1, AW033855.1 , AI655831.1, AW642591.1, AW321115.1, AW234483.1, AI142271.1 , AU008944.1 , AA755708.1, ACOl 1316.8, AP000487.2, AC025413.2, ACOl 7785.1, AC008687.3, AC016968.i l, AC018355.10, AC013543.4, AC034187.1, AC023866.2, AC025210.2, AC016968.10, AF216798.1, AC068529.1, AC022327.6, AC021514.3, AC027703.1, AC021556.3, AC013263.3, AC017682.1, AL355980.2, AL162491.3, AL158038.2, AC063958.7, AC040991.2, AC055744.2, AC023883.4, AC025732.3, AC053503.3, AC026270.2, AC068719.1, AC068658.1 , AC008402.4, AC068152.1, ACOl 1645.3, AC025640.3, AC009504.3, AC010086.3, AC021 107.2, AC009952.3, AC026009.2, AC019001.3, AC008466.2, AC022545.3, AC020879.2, AC007520.6, AC015875.1 , AC021413.1, AC014270.1, AC007835.5, ACOl 1624.4, AC013501.1 , AC010141.1, AL122019.21, AL355333.3, AL157784.3, AL353147.3, AL157397.2, AL158813.3, AL353722.2, AL139820.2, AL138883.4, AL138933.1, AP002010.1, AP001324.1 , AP000915.2, AP000562.2, APOOl 104.1

SEQ ID NO: 503 ZH140 T3 NM_003625.1 , AF034799.1 , NM_003626.1 , U22816.1 , U22815.1, LI 6840.1 , AC006695.1 , AF053008.1 , L06326.1 , Z49066.1, AC025808.8, AC010494.4, AC024609.2, AF224669.1 , AF079271.1, AC005800.1, AF104919.1 , AC003684.I , AL132776.i l, AL161492.2, AL133012.1, Z75747.1, Z83827.1, AL022152.1, AL008629.9, AL022575.1, AB009048.1, AW046469.1, AW163189.1, AV216286.1, AV098238.1 , AW651017.1 , AW648174.1, AV383282.1, AA132209.1 , N65637.1, R98374.1, ACOl 1316.8, AC069228.1, AP001787.1, AP000487.2, AC022764.3, AC022788.2, AC006740.2, AL139045.7, AC017043.3, AC021122.3, AC020715.2

SEQ ID NO: 504 ZH023/T3 AP000346.1, AP000345.1, AL136419.2, AL023753.1, AL035587.5, AC008103.27, AC007326.28, AFI64615.1, AF164614.1, AF164609.1 , X72791.1, Y17834.1, Y10392.1, AC008996.5, AF164610.1, Y17832.2, AF074086.1, AF164611.1, Y17833.1, Y18890.1, AC016577.4, AF164613.1, AL121985.13, Y10390.1, Y08032.1, AF164612.1, M14123.1 , AL031668.20, AC004034.1, AF240627.1, AL163218.2, AL109763.2, AC004979.1, AF018155.1, AF018154.1, AF018153.1, AC003072.1, AC006998.2, AC004889.1, AB020866.1, M77994.1, AI824517.1, AA218808.1, AI267359.1, AW527945.1, AW632310.1, AW632272.1, AI959137.1, AA335344.1, AC009761.4, AC022412.3, AC012068.3, AC022770.4, AC034203.3, AF235103.1, AC024690.2, AC022703.1 , AL158815.4, AC006078.1, AP000776.1 , AC024108.5, AC044819.2, AC055116.2, AC023074.2, ACOl 1467.5, AC026957.2, AC004127.1, AC008726.4, AC008535.3, AP000869.1, AP000714.1, AC025420.4, AL355987.3, AC015686.2, AP000831.1 , AC021655.8, AL121932.15, AC068728.3, AC018829.3, AC018809.3, AC026685.1, AC022007.2, AC024612.1, AC021996.1 , AL353807.3, AC067827.1, AC060818.2, AC055887.1, AC021973.2, AC012309.6, AC010632.5, AC027082.2, AC025757.2, AC012282.3, AC068099.1, AC069047.1, AC0I2043.5, AL356095.1, AC041049.2, AC008750.6, AC024725.2, AC024710.2, AC009505.2, APOOl 161.1, AC007322.3, AC024236.3, ACOl 1060.5, AL160407.4, AC024884.6, AC010640.5, AC008517.4, AC027524.2, AC025659.2, AC062019.1, AC034166.2, AF238379.1, AC021878.2, AC026854.1, AC022182.3, AC012407.2, AP001583.1 , AP001865.1, AC069151.1, AC068541.2, AC025187.3, AC068030.1, AC009504.3, AC010086.3, AC044825.1, AC027051.1, AC022631.3, AL03101 1.20, AP002O13.1. Z95393.1

SEQ ID NO: 505 ZH023/T7 AP000346.1, AP000345.1, AL035587.5, AB016195.1 , AL031668.20, U64453.1, M30520.1, AC016577.4, AC007326.28, AF164611.1, AF164610.1, AF164609.1, M14123.1, AF164612.1, AF074086.1 , AF164614.1, Y17832.2, Y.17834.1 , Y17833.1, AF164613.1, AL121985.13, Y18890.1, AC008996.5, Y10391.1, AF240627.1, AL109763.2, AL163218.2, M11348.1, AD000090.1 , AC004220.1, AF164615.1, AL023753.1, AC012005.3, AC006328.4, X82272.1, AF080231.1, AF080230.1, X92887.1, AF080229.1 , AF080234.1 , AC003100.1, AF080232.1, AF080233.1 , AL022154.1, AC006383.2, AC000385.1, AL109963.4, AB020866.1, AC004924.2, Z99129.1, AC006998.2, AF228552.1, U91321.1, AF033807.1 ,

AC005858.1, X01811.1, M15122.1 , K01707.1, K01788.1, AC006346.1, AC0021 13.1 , AF020092.1, U27242.1, U36927.3, AE002133.1, AF016685.1, AL035593.11, X78560.1, L27838.1, AF130358.2, AL161639.4, AL 160008.1 , AC025638.3, AL158815.4, AL356375.1, AF235103.1, AL136108.3, AC015623.3, AC006078.1, AC004127.1, AC024690.2, AC012068.3, AC044819.2, AC009761.4, AC034203.3, AC008726.4, AC008535.3, AC015686.2, AC015525.3, AP000869.1, AC053497.2, AL121932.15, AP000714.1, AP001636.1, AP000576.2, AC068728.3, AL159984.3, AL353807.3, AP000776.1, AC022770.4, AC010508.5, AC025420.4, AC024108.5, AC027082.2, AP000831.1, AL355987.3, AC023586.2, AC067789.1, AC008813.4, AC012309.6, AC068020.1, AL356356.1, AC010467.6, AL031963.25, AC026299.2, AC010632.5, AC026957.2, AC055116.2, AC023074.2, ACOl 1467.5, AC027605.4, AC068099.1, AC026685.1, AC022007.2, AC018829.3, AC018809.3, AC024612.1, AL137789.2, AL137022.7, AC068974.1, AC068369.1, AC022412.3, AC021996.1, AP000941.2, AC018865.1, AC026921.2, AP001958.1, AC024029.3, AC019121.2, AC025059.2, AF231129.1, AF228730.1, AC016095.1, AC008155.6, AL162734.3, AC021 112.3, AC010332.6, ACOl 1313.5, AC034166.2, AC021 135.3, AC026854.1, AL160407.4, AC034259.2, AC048384.2, AC010989.3, AL121954.4, AC021560.3, AC022482.3, AC022631.3, AL162739.4, AC010636.5, AC008976.7, AC008554.6, AC027417.1 , AC024710.2, AC022674.2, AC015688.3, AI080480.1, AI651023.1, AI867418.1, AW003247.1, AI631703.1, AA502500.1, AI352545.1, AI206199.1, AI671282.1, AI652535.1, AW451866.1, AA471088.1, AI818326.1, AA206342.1 , AA206331.1 , AA126128.1, AA206100.1, AW818I40.1, AA204834.1, AW665466.1, AI480345.1, AW021661.1, AA207155.1, AA206214.1, AI493192.1, AW818171.1, AW137742.1, AI478370.1, AA528309.1, AA248638.1, AW014214.1, AI818145.1 , AI634842.1, AI360447.1, R80905.1, AW013827.1 , AWl 82936.1, AI632006.1 , AI362712.1, AA206294.1, R79237.1, AA995742.1, AI214968.1 , AF147777.1, AF147766.1, AI326122.1 , AI025177.1, AA175218.1 , AV420643.1, AV412674.1, AW593524.1, AW414284.1, AW414173.1, AW229810.1,

AW215773.1, AW211857.1, AI869224.1, AI386228.1, AI385888.1, AI379846.1, AI275423.1, AA212523.1, AA123410.1, R82513.1, R67081.1, Z19676.1

SEQ ID NO: 506 ZH042/T3

AP000346.1, AP000345.1 , AL035587.5, AL136419.2, AL023753.1, AC004034.1 , AL031668.20, AC008996.5, AF164610.1, Y17833.1, AF164615.1, AF164614.1, Y17834.1 , AC016577.4, AC008103.27, AC007326.28, AF164613.1, AF164612.1, AF164611.1, AF164609.1, X72791.1, M14123.1, Y10392.1 , Y10390.1, Y08032.1, Y17832.2, AF074086.1, AL121985.13, Y18890.1, AF240627.1, AL163218.2, AL109763.2, AC004979.1, AF018155.1, AF018154.1, AF018153.1, Z58085.1 , AC003072.1, AC006998.2, AC004534.1, AC004889.1, AJ249770.1, AP000007.1, L20047.1, L01950.2, AC003999.1, U91321.1 , AC007393.3, AC008072.3, AC002306.1 , ALl 61544.2, AL034376.10, U86554.1, Z93020.1, AL031407.3, Z97341.2, AB029388.1 , ABO 16877.1 , M77994.1, AA218808.1, AI267359.1 , AI824517.1, AW527945.1, AI883693.1, AW730784.1, AW632310.1, AW632272.1 , AI876468.1, AI606839.1, AI465885.I , AA790298.1, AC009761.4, AL158815.4, AC022412.3, AC012068.3, AC022703.1, AC024690.2, AF235103.1, AC034203.3, AC022770.4, AP000776.1, AC044819.2, AC026957.2, AL353807.3, AC025420.4, AL355987.3, AC0551 16.2, AC023074.2, AC024108.5, AC021655.8, AC008726.4, AC008535.3, AP000869.1 , AP000714.1, AC006078.1, AC004127.1, AC060818.2, AC068728.3, AC055887.1, AC012309.6, AC010632.5, AC011467.5, AL121932.15, AC025757.2, AC027082.2, AP000831.1, AC021973.2, AC015686.2, AC026685.1, AC022007.2, AC018829.3, AC018809.3, AC024612.1, AC021996.1, AC012282.3, AC069047.1, AC026196.1, AC027524.2, AC067827.1 , AC012043.5, AL356095.1, AC008750.6, AC024725.2, AC024710.2, AC009505.2, APOOl 161.1 , AC007322.3, AC024236.3, ACOl 1060.5, AC026781.2, AC010640.5, AC008517.4, AC024658.3, AC021878.2, AC021416.3, AL355513.1, AP001583.1, AP001865.1, AC016967.9, AC021201.3, AC055810.2, AC025448.3, AC008755.5, ACOl 1386.4, AC040900.2, ACOl 1448.2, AC023888.6, AC016805.3, AC022197.3, AC037197.1, AC034179.2, AC027210.1, AC027051.1, AC007460.2, AC024443.2, AC022866.2, AC023190.2, AC016967.8, ACOl 1716.2, AC012191.2, AC012229.2, AC016200.1, AL161941.7, ALl 17376.27

SEQ ID NO: 507 ZH042/T7 AP000346.1, AP000345.1, AL035587.5, AB016195.1, M30520.1, U64453.1, AL031668.20, AC016577.4, AC007326.28, AF16461 1.1, AF164610.1, AF164609.1, M14123.1, AF164612.1 , AF074086.1, AF164614.1, Y17832.2, Y17834.1, Y17833.1 , AF164613.1 , AL121985.13, Y18890.1, AC008996.5, Y10391.1, AF240627.1, AL109763.2, AL163218.2, AD000090.1, M11348.1, AC004220.1, AF164615.1 , AL023753.1, AC012005.3, AC006328.4, X82272.1, AF080231.1, AF080230.1 , AF080229.1 , AF080234.1 , AF080232.1 , AF080233.1 , U47118.1 , X92887.1 , AC003100.1 , AL022154.1 , AC006383.2, AC000385.1, AL109963.4, AB020866.1, AC004924.2, Z99129.1, AC006998.2, AF228552.1, U91321.1, AF033807.1, X01811.1, M15122.1, K01707.1, K01788.1, AC0021 13.1, AF020092.1, U27242.1, AF130358.2, AL163241.2, AJ009632.2, AP001696.1, AI651023.1 , AI080480.1, AW003247.1, AI867418.1, AI631703.1, AA502500.1, AI352545.1, AI206199.1, AI671282.1, AI652535.1, AW451866.1 , AI818326.1, AA471088.1, AA206342.1 , AA206331.1, AA206100.1 , AA126128.1, AW818140.1, AW665466.1, AA204834.1, AI480345.1 , AI493192.1, AW021661.1, AA206214.1, AA207155.1, AW818171.1, AA204833.1 , AW137742.1, AI478370.1, AA528309.1 , AA248638.1,

AW014214.1 , AI818145.1, AI634842.1, AI360447.1, R80905.1, AW496808.1, AW013827.1, AW182936.1, AI632006.1 , AI362712.1, AA206294.1, AA206262.1, AA995742.1 , AVI 72265.1, AI214968.1, AI326122.1 , A W414284.1, AW414173.1, AW211857.1, AL161639.4, AL160008.1, AC025638.3, AL158815.4, AF235103.1, AL356375.1 , AC015623.3, AL136108.3, AC012068.3, AC024690.2, AC006078.1, AC004127.1, AC044819.2, AC009761.4, AC008726.4, AC008535.3, AC015686.2, AC015525.3, AP000869.1, AC053497.2, AL121932.15, AP000714.1, AC068728.3, AL159984.3, AC034203.3, AP001636.1, AP000576.2, AC022770.4, AC025420.4, AC010508.5, AL353807.3, AP000776.1, AC024108.5, AC027082.2, AP000831.1, AC023586.2, AL355987.3, AC008813.4, AC012309.6, AC067789.1, AC068020.1, AL356356.1, AC010467.6, AC010632.5, AC026957.2, AC026299.2, AL031963.25, AC055116.2, AC023074.2, AC027605.4, AC011467.5, AC068974.1, AC068099.1, AC026685.1, AC022007.2, AC018829.3, AC018809.3, AC024612.1, AL137789.2, AL137022.7, AC068369.1, AC022412.3, AC021996.1, AP000941.2, AC018865.1, AC026921.2, AP001958.1, AC024029.3, AC019121.2, AC025059.2, AF231 129.1, AF228730.1, AC016095.1, AC008155.6, AL162734.3, AC021112.3, AC010332.6, AC034166.2, AC021 135.3, AC026854.1, AL160407.4, AC034259.2, AC048384.2, AL121954.4, AC026615.2, AC021560.3, AC022482.3, AL162739.4, AC010636.5, AC008976.7, AC008554.6, AC027417.1, AC024710.2, AC022674.2, AC015688.3

SEQ ID NO: 508

ZH1347/T3

AP000346.1, AP000345.1, AL035587.5, AL023753.1, AL136419.2, AC004979.1 , AL020995.13, AC004034.1, AL031668.20, AC008103.27, AC007326.28, AF164609.1, Y08032.1, AF074086.1, AF164615.1 , AF164614.1 , AF16461 1.1 , Y17834.1 , Y17833.1, Y17832.2, AC016577.4, AF164610.1, AC008996.5, AF164613.1, X72791.1, M14123.1, Y10390.1, Z86090.10, AF164612.1 , AL121985.13, Y18890.1, AL109763.2, AF240627.1, AL163218.2, AC002350.1, AC004976.1, Z58084.1, Z63110.1, AF078838.1, M12855.1, AC007325.51, M12853.1, M12851.1 , X72790.1, X82271.1, AC004164.1, U32496.1, AF018155.1, AF018153.1, AL121934.15, AB020866.1, AC003973.1, AC009958.2, AF020503.1, AL137080.2, AC009263.6, AC006565.3, AC005625.1, AC003694.1, AF003473.1, AL161566.2,

AL030978.1, AL080276.9, Z36282.1, Z70203.1, Z84483.1, VO 1555.1, U62645.1 , U70852.1, M80517.1, U51994.1, AB009666.1, AB017328.1, AI623315.1, AA196978.1 , AI917742.1, AI632501.1, AI635368.1, AA704457.1 , AI052645.1, AI970327.1, AI052188.1 , AW298218.1, AA922960.1, AA002001.1, N80921.1, W02825.1. N41549.1, N39695.1, N26360.1, N26114.1, H83743.1, W16915.1, W02818.1, H12051.1, AA205546.1, AW863012.1, AV134770.1, AI700982.1, AF009724.1, AA233105.1, AI558891.1, AI149795.1, AA525739.1, AA403229.1, AA092763.1, W01643.1, N62346.1, AL355987.3, AC022412.3, AF235103.1, AL158815.4, AL136108.3, AC022770.4, AC068020.1, AC034203.3, AC024690.2, AC006078.1, AC008813.4, AL121932.15, AC026786.2, AC027524.2, AC004127.1, AC010930.4, AC026338.4, AC026005.2, AC025638.3, AC012309.6, AC009758.2, AC022262.3, AC010632.5, AC026685.1 , AC026196.1, AC022007.2, AC018829.3, AC018809.3, AC024612.1, AC021996.1 , AC008785.3, AC009761.4, AP000776.1, AC0551 16.2, AC023074.2, ACOl 1467.5, AC026957.2, AC025420.4, AC008726.4, AC008535.3, AC021973.2, AP000869.1, AP000831.1, AP000714.1, AC044819.2, AC068942.1 , AC067827.1 , AC027082.2, AC068728.3, AC015686.2, AC025757.2, AL353807.3, AC012068.3, AC026484.3, AL353789.1, AC012282.3, AC009771.4, AC023252.2, AC060818.2, AC069047.1, AC021655.8, AP001636.1, AP000576.2, AC009769.3, AC008379.5, AC024108.5, AC020933.4, AC020919.4, AC012619.5, AL162734.3, AC026854.1, AL121960.1, AC041049.2, AC018867.2, AC067732.2, AC022734.2, AC027456.2, ACOl 1881.5, AC018807.4, AC022600.1, AC027382.2, AC024067.3, AC053522.1, AC008272.1

SEQ ID NO: 509 ZH1347/T7

AP000346.1, AP000345.1, AL035587.5, AL136419.2, AL023753.1, AD000090.1, AC004979.1, AF074086.1, AF164615.1, AF164614.1, AF16461 1.1, AF164609.1, Y18890.1, Y17834.1, Y17833.1, Y17832.2, Y10392.1, AL121985.13, AF240627.1, AC008103.27, AC007326.28, AF164612.1, AL163218.2, AL109763.2, AC008996.5, AC016577.4, AF164613.1, AF164610.1, M14123.1, U91321.1, AC007379.2, AL078590.27, Y08032.1, AC003072.1, AC010329.3, Y10390.1, AC008173.2, X77925.1, AE003645.1, AE003411.1, AC006167.1, AC003949.1, U92876.1, Z78418.1,

Z70280.1, AJ224356.1, AB007021.1, AP00051 1.1 , AP000815.1, AB028605.1, AB023050.1, AC012005.3, AC006328.4, AC008567.4, AF241734.1, AE003777.1, AE003765.1, AC012085.4, AC006331.2, AC012477.1, AF020092.1, AF027336.1, AL161573.2, AL161503.2, AL078469.2, AL050312.8, AL022154.1, X01729.1 , AA923278.1 , AI341975.1, AI650511.1, AI961064.1 , AAl 96979.1 , AW236545.1 , AWl 39686.1, AI964001.1 , AI824860.1 , AI634418.1 , AA91 1045.1 , H77777.1, AW835451.1, AW142813.1, AA943262.1, N40303.1, N95674.1 , N36327.1 , N34083.1, AW385862.1, AW010495.1, AI009266.1, AW551014.1, AV370696.1, AV364309.1, AV350688.1, AV331599.1, AV311030.1 , AV310095.1, AV277892.1, AV277769.1, AV277196.1, AV275289.1, AV275221.1, AV270694.1, AV267738.1, AV265513.1, AV258263.1, AV257384.1, AV243092.1, AV215936.1, AI852680.1, AV158672.1, AV172070.1, AV146175.1, AV137435.1, AI613692.1, AI482010.1 , AA623529.1, AA585880.1, AA516681.1, AA393031.1, AA389342.1, AA056004.1, N59888.1, H81356.1, AC009761.4, AC009769.3, AL158815.4, AC034203.3, AC024690.2, AC022770.4, AC012068.3, AC022703.1 , AL121932.15, AC012309.6, AC010632.5, AC025420.4, AC044819.2, AC010508.5, AC055116.2, AC023586.2, AC023074.2, AP000869.1, AP000831.1 , AC027082.2, AC022007.2, AC018829.3, AC018809.3, AC021996.1, AL355987.3, AC015686.2, AP000714.1, AC025699.4, ACOl 1467.5, AC008946.4, AC068728.3, AC008535.3, AC068099.1, AC026957.2, AC026685.1 , AC024612.1, AC006078.1, AC004127.1, AL353807.3, AP000776.1, AC023883.4, AC008539.3, ACOl 1541.3, AC068379.1, AC021 107.2, AC010141.1, AC027293.3, AC024108.5, AC022631.3, AC022486.3, AL137789.2, AC008726.4, AC026921.2, AL121970.10, AL161669.1, AC068322.1, AC027713.2, AC027284.1, AC024059.2, AC009504.3, AC010086.3, AC024725.2, AC022882.3, AC022586.1, AC009505.2, AC012059.5, AC020891.4, AL031744.7, ACOl 1313.5, AC023598.10, AC023597.8, AC022993.3, AC012663.3, AC007991.2, AC068369.1, AC026010.2, AC021560.3, AL137064.2, AC069185.1, AC026775.2, AC013798.4

SEQ ID NO: 510

Acidic 82 kDa

NMJH4597.1, U15552.1, AL033375.2, AB018117.1, X78035.1, AC061957.3, AE003665.1, AC004541.1, AC004240.1, AC000047.6, AC006215.1, AC003665.1, AC003658.1, Y12776.1, NM_014154.1, AE003463.1, AE002612.1, AC006825.1, AC006679.2, AF161541.1, AF204231.1, AC004883.2, AC005534.2, AC007736.3, AC007385.3, AC008124.8, AC005520.2, AC005968.1, AC003019.1, AC004388.1, AC003687.1, AF039586.1, AL163202.2, AL137686.1 , ALl 17569.1, AL049749.2, AJ239318.3, Z99281.1, Z68006.1 , AL021786.1, AJ245583.1, APOOl 135.2, AP000604.1, Z83733.1, AB023152.1, AB020662.1, X68393.1, X71424.1, U04436.1, AW604388.1 , AW578439.1 , AA772816.1 , AW604383.1 , AA171806.1, AA223318.1 , AA300576.1, AW577851.1, X85657.1, AW366303.1, AW366304.1, AW366300.1, AW366302.1, AW784397.1, AW366308.1 , AWl 06818.1, AI892034.1, AI790951.1, AAl 04392.1, AA098311.1, AW323362.1, AI548718.1, AV239176.1, AW401090.1, AW401089.1 , A W400879.1, AW400878.1, AW036673.1, AU085757.1 , AW511512.1, AW470214.1 , AW330749.1, AW316831.1, AW196290.1, AW193248.1, AW190941.1, AW190240.1, AI928455.1, AI760032.1, AI695865.1 , AV005974.1, AI640805.1, AI623468.1, AI567745.1, AI565060.1, AI206916.1, AI204039.1, AH08782.1, AI041845.1, AA953940.1, AA847791.1, AA440362.1, AA620779.1, AA456818.1, AA257418.1, AA243360.1, W65778.1 , W23329.1, H80920.1, AL049796.27, AL160163.3, AC026139.1, AL159985.5, AC021056.4, AC026674.4, AC009429.3, AC019322.3, AC037466.2, AC058816.2, AC031988.2, AC026570.2, AC027200.2, AC026610.2, AC027580.1, AC012089.10, AC010799.2, AC021948.3, AC022049.3, AC017053.5, AC023860.2, AC021682.1, AC017550.1, AC012021.1, AL139257.5, AL355857.1, AL354933.1, AL158847.2. AL049180.3

SEQ ID NO: 511 ZH12110/T3

NM H4597.1, U15552.1, AL033375.2, AE003665.1, AC006215.1, AC003665.1, NM H4154.1, AF161541.1, AC005534.2, AC007736.3, AC007385.3, AC005280.2, AC005520.2, AC004464.1, AC005968.1, Ul 7097.1, AF039586.1, AL163202.2, AJ239318.3, Z68006.1, AL034351.1, AL031007.1, AL022164.1, AJ245583.1, APOOl 135.2, AP000604.1, X71424.1, AW604388.1, AW578439.1, AA772816.1, AW604383.1, AA171806.1, AA223318.1, AA300576.1, AW577851.1, AW784397.1 , AWl 06818.1, AI892034.1, AI790951.1, AA104392.1, AA098311.1, AW323362.1, AW330749.1, AW091879.1, AW091878.1, AI301 143.1, AI206916.1 , AA257418.1, W23329.1, AL049796.27, AL160163.3, AC021874.12, AC021023.4, AC018656.5, ACOl 1312.5, AC022504.9, AC022362.5, AC007944.2, AC021874. i l, AL159985.5, AC021056.4, AC026674.4, AC009429.3, AC031988.2, AC027200.2, AC027580.1 , AC012089.10, AC021948.3, AC022049.3, AC023860.2, AC021682.1, AC017550.1, AC012021.1, AL355857.1, AL354933.1, AL158847.2, AC069154.1 , AC068777.3, AC069224.1, AC068810.1, AC019109.3, AC063969.1, AC026690.2, AC025770.3, AC022424.3, AC010269.3, AC068159.1, AC068144.1 , AC023390.2, AC067978.1 , AC067924.1, AC025640.3, AC015979.3, AC020559.3, AC007034.3, AC009717.4, AC007343.3, AC012336.2, ACOl 1193.2, AC024739.3, AC016100.4, AC016012.5, AC020583.2, ACOl 1 177.3, AC023232.3, AC017085.2, AC012460.3, AC021510.2, AC015532.1, AC009687.2, AC009878.3, AC016076.1 , AC016001.1, AC009638.2, U82207.1, AL354752.4, AL139797.3, AL352979.1, AL159141.1, AL136332.1

SEQ ID NO:512

ZH12U0/T7

NM_014597.1, U15552.1, AC005274.1 , U41534.2, U20863.1, Z81586.1, Y11477.1, NC .001148.1 , AE003673.1,

U18997.1, AC007576.3, AC001653.1, AE001573.1, AE000420.1, AF029714.1, AL163233.2, AJ251790.2, U77617.1, Z75529.1, Z73617.1, X07378.1 , X15119.1, J02802.1, AP001688.1, AP000474.2, AP000371.1, AJ222744.1, V00262.1,

AW262098.1 , AI81 1119.1 , AI916666.1 , AA588547.1 , AI090265.1 , AA559096.1 , AA548959.1 , AI078150.1 , AI921686.1 , AI064798.1, AA512919.1, AI953413.1, AI584020.1, AI420425.1, AI440083.1, F24260.1 , AA171691.1, AA223220.1 , AI589491.1, AI632721.1, AA191324.1 , AW515936.1, AA180035.1, AW304051.1, AI291339.1, AI039210.1, AW015039.1, AI039762.1, AA558329.1, AI630570.1, AW548819.1, AI436814.1 , W38442.1, W44843.1, AA15411 1.1, AW743841.1, T10610.1, AA900652.1, AW743746.1, AW822976.1, AW123455.1, AW368407.1, AW520538.1, AW123632.1, AW107758.1, AU045884.1, AW368395.1, AW744309.1, AA163090.1, AI029049.1, AA408582.1, AA266615.1 , AA571872.1, AW579113.1, AA163319.1, AI125024.1, AA199338.1, C85561.1, AI929717.1, AA231163.1, AW747936.1, AW163410.1, AW160946.1, AI872259.1, AA198766.1, AW368408.1, AV139960.1, AA090602.1, AI267670.1, AW323159.1, AA615636.1, AV373964.1, AV241006.1, AI585726.1, AA140264.1, AV232403.1 , AW321909.1, AI926471.1, AA231166.1, AI426672.1, AA56271 1.1, AA458205.1, AAl 83585.1 , AV294202.1, AV321882.1, BB001603.1, AV307214.1, AA832262.1, AA718642.1, AV307617.1, AV324587.1, AV321231.1, AV236999.1, AV136158.1, AA441847.1, AW838681.1, AV126308.1, AWl 75429.1 , AI959131.1, AI957849.1, AL049796.27, AC040952.1, ACOl 1140.3, AC055112.1, AL138822.4, AL139005.1, AC012496.4, AC023332.3, AC022266.3, AC019264.3, AC023995.2, AL138755.3, AL160235.1, AL009107.1, AC018356.8, AC011321.9, AC069202.1, AC027484.3, AC027689.5, AC026784.2, AC020918.4, AC018756.3, AC016585.2, AC016608.4, AC016638.4, AC008782.4, AC008767.4, AC026936.2, ACOl 1121.4, AC055878.1 , ACO 15960.4, AC015666.3, AC021214.3, AC012433.5, AC024353.2, AC011584.4, AC023021.2, AC020758.1, AC016570.2, AC009862.3, AC023083.2, AC009938.2, AC021110.2, AC022595.1 , AC022025.1, AC012761.1, AL162495.3, AL139015.2, AL136105.4, AL355477.1 , ALl 62590.2, AL161897.3, AL035689.25, AL159972.3, AL158054.5, AP001499.1, AP001390.1

SEQ ID NO: 513

ZH13410/T3

NM_014597.1, U15552.1, AL033375.2, AB018117.1, X78035.1, AC061957.3, AE003665.1, AC004541.1, AC004240.1, AC000047.6, AC006215.1, AC003665.1, AC003658.1, Y12776.1, NM_014154.1, AE003463.1, AE002612.1 , AC006825.1, AC006679.2, AF161541.1, AF204231.1 , AC004883.2, AC007736.3, AC005520.2, AC003O19.1, AC004388.1, AC003687.1, AF039586.1, AL163202.2, AL137686.1, ALl 17569.1, AL049749.2, AJ239318.3, Z99281.1, Z68006.1, AL021786.1, AJ245583.1, APOOl 135.2, Z83733.1, AB020662.1, X68393.1, X71424.1, U04436.1, AW604388.1, AW578439.1, AW604383.1, AA772816.1, AA171806.1, AA223318.1, X85657.1, AW366303.1 , AW366304.1, AW366300.1, AW366302.1, AW366308.1, AW106818.1, AI892034.1, AI790951.1, AA104392.1, AA09831 1.1, AW323362.1, AI548718.1 , AV239176.1, AW036673.1, AU085757.1, AW511512.1, AW470214.1, AW330749.1, AW316831.1, AW303487.1, AW196290.1 , AW193248.1, AW190941.1, AW190241.1, AW190240.1, AI958173.1, AI928455.1, AI878341.1, AI858859.1, AI760032.1, AI695865.1, AI693200.1, AV005974.1, AI567745.1, AI496943.1 , AI475797.1, AI392330.1, AI206916.1, AI204039.1, AI204038.1, AI108782.1, AI081793.1, AI041845.1, AI017315.1, AI004888.1, AA953940.1, AA847791.1, AA789537.1, AA440362.1, AA620779.1, AA610092.1, AA456818.1,

AA417164.1, AA257418.1, AA243360.1, W65778.1, W23329.1, H80920.1, AL049796.27, AL160163.3, AC026139.1 , AL159985.5, AC026674.4, AC058816.2, AC031988.2, AC026570.2, AC026610.2, AC027580.1, AC012089.10, AC021948.3, AC017053.5, AC021682.1 , AC017550.1, AL139257.5, AL049180.3, AC069154.1, AC040992.2, AC025678.2, AC027481.2, AC021822.3, AC021840.3, AC027261.1, AC021862.3, AC019314.2, AC011753.2, AC017085.2, AC013725.2, AC016076.1, AL356318.1 , AL121953.13, AL158825.6, AL352979.1, AP001496.1,

SEQ ID NO:514 ZH141 T3 NM_014597.1, U15552.1, AL033375.2, AE003665.1, AC005534.2, AC007736.3, AC0O7385.3, AC006215.1, AC005968.1, AL163202.2, AJ239318.3, APOOl 135.2, AP000604.1, AB023152.1, AW604388.1, AW578439.1, AA772816.1, AW604383.1, AA171806.1, AA223318.1 , AA300576.1, AW577851.1, AW784397.1 , AW401090.1, AW401089.1, AW400879.1, AW400878.1, AW330749.1, AI495597.1, AI392330.1, AA789537.1, AL049796.27, AL160163.3, ALl 59985.5, AC021056.4, AC026674.4, AC009429.3, AC031988.2, AC027200.2, ACO 12089.10, AC022049.3, AC023860.2, AC021682.1, AC012021.1 , AL354933.1, AL158847.2, AC069154.1, AC019109.3, AC063969.1, AC068159.1, AC023390.2, AC067978.1, AC067924.1, AC015979.3, AC007034.3, AC025917.3, AC012336.2, ACOl 1193.2, AC024739.3, AC026189.1, AC016100.4, AC016012.5, AC018822.3, AC009754.3, AC023232.3, AC012460.3, AC021510.2, AC009878.3, AC017550.1, ACO 16076.1 , ACO 12474.1, AC004480.7, AL13341 1.3, AL355433.1, AL159141.1, AL136332.1

SEQ ID NO: 515

ZH141/T7

NM_014597.1, U15552.1 , AC005274.1, AC004517.1, AC003972.1, AP001539.1, Yl 1477.1 , NC_001148.1, AC005169.2, AE003815.1, AE003673.1, Ul 8997.1, AC007576.3, AC006360.2, AC001653.1, AE001573.1, AE000420.1, AF029714.1, AL163233.2, AJ251790.2, Z75529.1, Z73617.1 , X07378.1, X15119.1, J02802.1 , AP001688.1, AP000474.2, AP000371.1, AJ222744.1 , V00262.1, X96547.1, AB009049.1, AW262098.1, AI811 1 19.1, AI916666.1, AI090265.1, AA559096.1, AA588547.1, AA548959.1, AI078150.1, AI921686.1, AA512919.1, AI064798.1, AI953413.1 , AI440083.1, AI420425.1, AI584020.1, F24260.1, AA171691.1, AA223220.1, AI589491.1, AI632721.1, AA191324.1, AW515936.1, AA180035.1, AI291339.1 , AI039210.1 , AW304051.1, AW015039.1, AI039762.1, AA558329.1, AI436814.1, AW548819.1, AI630570.1, AA154111.1, W38442.1, W44843.1, AW743746.1, T10610.1, AW743841.1, AW822976.1, AA900652.1, AW123455.1, AW520538.1, AW123632.1, AW107758.1, AU045884.1, AI029049.1, AA408582.1, AA266615.1, AW744309.1, AW579113.1, AA571872.1 , AA163090.1, AI125024.1, C85561.1, AA231163.1, AW368407.1, AW368395.1, AI929717.1, AA199338.1, AW163410.1, AW160946.1, AI872259.1, AA163319.1, AA090602.1, AV139960.1, AI267670.1, AI585726.1 , AW323159.1, AV373964.1, AV241006.1, AA140264.1, AW368408.1, AA198766.1, AW321909.1, AA231166.1 , AV232403.1 , AA615636.1 , AI426672.1 , AV294202.1 , AV321882.1 , AV307214.1 , AA832262.1 , BB001603.1, AV307617.1, AV324587.1, AV321231.1, AV236999.1, AV136158.1, AA562711.1, AV126308.1, AW747936.1, AA718642.1, AA458205.1, AA183585.1, AV365167.1, AV365148.1, AV061094.1, AW175429.1, AI959131.1, AI957849.1, AL049796.27, AC040952.1, AC011140.3, AC0551 12.1, AC013448.3, AL139005.1, AC023332.3, AC022266.3, AL138755.3, AL355100.1, AL160235.1, AL162832.1, AC069202.1, AC053493.4, AC015960.4, AC012433.5, AC018401.2, AC010987.4, AC018520.2, AL354694.2, AL158037.6

SEQ ID NO: 516

Progestin Induced protein (DD5)/KIAA0896 AB020703.1, NM_015902.1 , AF006010.1, X64411.1, AF029676.1, AF029675.1, AF151830.1 , NM_016018.1,

AF230666.1, AE003557.1, AE003468.1, AF237948.1, AE003798.1, AE002987.1, U82806.1, AF052145.1, AC004345.1, AC004298.1, Z97055.1 , Z46918.1, M29295.1, AF145117.1 , ACOl 1229.2, AE003671.1, AE003480.1, AE003470.1, AC008015.5, AC005836.2, AC004145.3, NM_003375.1, AC004787.1 , AFl 52220.1, AC004185.1, AC006048.1, AL163303.2, L06328.1 , AL160371.1, Z83731.1, M20162.1 , AP000509.1, D84394.1, K00046.1, Dl 1474.1, AL042261.1 , AA183561.1, AA063910.1, AAl 77260.1 , AAl 10008.1, AA727714.1, AW749472.1, AA087561.1, AI643062.1,

AI222185.1 , AA800061.1, AA284046.1, R01391.1, AI986716.1, AI976300.1, AI975036.1, AI676486.1, AI533970.1 , AI395619.1, AI394872.1, AA990702.1, AA423063.1, T14459.1, AW650379.1, AW463925.1 , AW140713.1, AW096747.1, AW092707.1, AW041685.1, AI775589.1, AI774313.1 , AI774312.1, AI542582.1, AI533621.1, AI531106.1, AI530938.1, AI411893.1, AI293423.1, AA123288.1, H31286.1, AW651695.1, AW247714.1, AV218869.1 , AV212478.1, AW087404.1, AL038544.1, AV089206.1, AI755888.1, AV007740.1, C96439.1, C96271.1 , AI529204.1, AU039069.1, AU038173.1,

AA546255.1, AA386122.1, AA307929.1, AA207547.1, AA163566.1, AA146410.1, AA089612.1, AA087456.1, R75858.1, R01776. I, AC021004.3, AF216669.1, AC009708.2, AC009622.4, AF228727.1, AC016768.4, AC018467.3, AC006591.12, ACOl 1907.2, AC019758.1, AC017811.1, ACO08303.1, AL022475.12, AC022321.4, ACOl 1181.5, AC017574.1, AC018326.1. AL159982.5

SEQ ID NO: 517

ZH072 T3

AB020703.1, NM_015902.1, AF006010.1, X64411.1, AE002987.1, AF1451 17.1, ACOl 1229.2, AE003671.1, AC004185.1,

AC006048.1, AL163303.2, Z83731.1, M20162.1, AP000509.1, D84394.1, K00046.1 , Dl 1474.1, AL042261.1, AA183561.1, AA063910.1, AA727714.1, AA110008.1, AA087561.1, AA177260.1, AI643062.1 , AA123288.1,

AA546255.1, AA087456.1, R75858.1, AC021004.3, AF216669.1, AC009708.2, AC016768.4, AC018467.3, AC017574.1, AL159982.5, AC015464.4, AC010027.4, AC060830.3, AC068706.2, AC025580.3, AC027148.2, AC053492.1, AC037195.1, AC024530.3, AC008226.9, AC010575.3, AC010714.3, AC022186.2, AC015271.1, AC009886.2, AL162413.3, AL162429.2, AL160276.2, AL157829.3, AL138721.3, AL138824.3, AL136455.2, AL133492.1

SEQ ID NO: 518

ZH072 T7

AC009223.2, AC005714.9, AF038584.1, AE000785.1, M28164.1, AE003694.1, AF124571.1, AC005698.1, AC007529.5,

AF129078.1, AL133162.2, Z81546.1, AL035475.6, AE003712.1, AF154675.1 , AL161533.2, AL161503.2, AL133166.2, Z77667.1, AL049638.1 , AW301225.1, AI566211.1, AI446174.1, AW592514.1, AI963798.1, AI687963.1, AA582316.1, AI830921.1 , H27633.1, D63110.1, AW196550.1, AW028213.1, D62775.1, C01631.1, AA382517.1, H27554.1, H13230.1, AA321967.1, H13597.1, AW427077.1, AA714833.1, AW427080.1, AI670697.1, AA827170.1, AA936393.1, AI108751.1, AI107920.1, AL120021.1, AI172671.1, AI553602.1, AA938191.1, AA811984.1, AA651844.1, AA521315.1, AW333372.1, AI249039.1, AC021004.3, AC009708.2, AC010802.4, AC061710.4, AC023281.9, AC017902.1, AC017105.5, AC051647.2, AC058823.2, AC009902.3, AC018735.5, AC018465.3, AC007692.3, AL139097.5, AL035087.18, AC010350.3, AC024437.2, AC012510.3, AC022180.1, AC013620.2, AC013681.1

SEQ ID NO: 519 ZH095/T3

AB020703.1, NM_015902.1, AF006010.1, AF029676.1, AF029675.1, AF151830.1, NM_016018.1, AF230666.1, AE003557.1, AE003468.1, AF237948.1, AE003798.1, U82806.1, AF052145.1, AC004345.1, AC004298.1, Z97055.1, Z46918.1, M29295.1, AE003480.1, AE003470.1, AC008015.5, AC005836.2, AC004145.3, NM_003375.1 , AC004787.1, AF152220.1, L06328.1, AL160371.1, AA183561.1, AA063910.1, AL042261.1, AA177260.1, AAl 10008.1, AW749472.1 , AI222185.1, AA727714.1 , AA800061.1, AA284046.1, R01391.1, AI986716.1, AI976300.1, AI975036.1, AI676486.1,

AI533970.1, AI395619.1, AI394872.1 , AA990702.1, AA423063.1, T14459.1 , AW650379.1, AW463925.1 , AW140713.1, AW096747.1, AW092707.1, AW041685.1 , AI775589.1, AI774313.1, AI774312.1, AI542582.1, AI533621.1, AI531106.1, AI530938.1, AI411893.1, AI293423.1, H31286.1, AW651695.1, AW247714.1, AV218869.1, AV212478.1, AW087404.1, AL038544.1, AV089206.1, AI755888.1 , AV007740.1, C96439.1, C96271.1, AI529204.1, AU039069.1, AU038173.1, AA386122.1, AA307929.1, AA207547.1, AA163566.1 , AA146410.1, AA089612.1, R01776.1, AC021004.3, AF216669.1, AC009708.2, AC009622.4, AF228727.1, AC016768.4, AC018467.3, AC006591.12, ACOl 1907.2, AC019758.1, AC017811.1, AC008303.1, AL022475.12, AC022321.4, ACOl 1181.5, AC018326.1 , AL159982.5, AC012325.5, AC027393.2, AC007318.3, AC012590.3, AC027148.2, AC046775.1, AC026048.2, AC025498.2, AC018421.3, AC019291.4, AC015525.3, AC023462.2, AC010747.3, AC014119.1, AC015395.1, AC006106.1, AL353791.2, AL353729.2, AL354747.3, AL157996.2, AL137069.1

SEQ ID NO: 520

ZH095/T7

AF090904.1, AK002172.1 , AB020703.1 , X64411.1, NM_015902.1, AF006010.1, AB005233.1, NM_016593.1, AF237982.1, AE003600.1, AE003470.1, NM_013337.1, AF155330.1, AC005597.1, U89959.1, AL035670.29, Z86075.1, AL035469.7, AL009174.1 , AK000830.1, AB026649.1, AC00755I .1, AC002521.2, AC006036.3, AF117829.1 , AF034470.1, AF034464.1, AL163152.2, AF016418.1, AL034582.11, Z71263.1 , AL021492.1, Z75551.1, AL031673.16, Z86063.1 , Y14082.1, AB022215.1, AB016891.1, Z99109.1, U69567.1, AI125532.1, AW274041.1, AA434064.1, AI569610.1, AA610288.1, AI041022.1, AW778740.1, AW264922.1, AW471208.1, AI41 1395.1, W95811.1, AI332805.I , AA894186.1, AW474117.1, AI024731.1, AA843441.1, AI469526.1, AW473231.1, W95857.1, AI237592.1, W95818.1,

AA725577.1, AI376892.1, AI237601.1, AI233371.1, AW268885.1, AW675227.1, N20661.1, AW149140.1 , AW104291.1, AI231043.1, AW580433.1, AW317070.1, AA927329.1, AA627267.1, AA128632.1, D45459.1, AI685703.1, AI675470.1, AA554058.1, AI689250.1 , AA905245.1, AA850460.1, AA757169.1, AA588884.1, AA504225.1, AA955278.1 , AW522026.1, AA956416.1, AI364772.1, T72574.1, AA851563.1, AA058906.1, AA646569.1, AA467485.1, AI137214.1, AW385164.1, AA043863.1, AW549941.1, AA076485.1, AI157047.1, AA170365.1, AA824035.1, AA712101.1,

AA621776.1, AI847142.1, AU020445.1, AU016788.1, AA122804.1, AW4891 14.1, AA169470.1, C77315.1, AW215446.1 , N29038.1, AA154114.1, AA075669.1, AA475847.1, AW481686.1, AW364486.1, AI596391.1, AW744029.1, AA538098.1, AA873964.1, AI325477.1, AA369775.1 , AVI 25774.1, AV250017.1, AV320673.1, AA254612.1, AV247937.1 , AV355877.1, AV370222.1, H88855.1, AV247745.1, AF074692.1, AH 10785.1, R70621.1, AJ397051.1, AA546580.1, AC021004.3, AF216669.1, AC062012.1 , AL355813.3, AL355587.3, AC026093.3, AC034199.3, AC066615.2, AC064813.1, AC019215.3, AC009704.3, AC021568.4, AC015526.3, AC015994.3, AC019253.3, AC020704.3, ACOl 1710.2, AC024660.2, AC020992.3, AC010211.8, AC019077.4, AC022201.2, AC019799.1, AC013185.1, AL157405.2, AC068706.2, AC053537.3, AC025461.3, AC016639.5, AC016632.4, AC03611 1.2, AC008730.4, AC06171 1.2, AC027497.2, AC009870.3, AC018891.2, AC016796.2, AC024627.1, AL353145.2, AP001830.1, AP001167.1

SEQ ID NO: 521

TRANSCRIPTION FACTOR 6-Like 1

NM_003201.1, M62810.1, X64269.1 , NM_012251.1, AB014089.1, NM_009360.1, U63859.1, U63858.1, U57939.1,

L07107.1, U63860.1, AL034386.2, AC009079.4, U35728.1, AC004695.1 , AL022239.1 , U91323.1, AC022073.13, AC007970.3, NM_014362.1, AC006552.7, U66669.1, AF013711.1, AF020932.1, AC002563.1, U73638.1 , AL008635.1, M58484.1, AC006038.2, AC018655.5, AC007911.8, AC004991.1, AF096371.1, AC007123.1, U14101.1, AP001434.1, AI928504.1, AW340722.1, AW269796.1, AI769813.1, AA625849.1, AI862124.1, AA449551.1, AA995790.1, AA758646.1, AW303542.1, AA102499.1, AI473739.1 , AI090110.1, AW666007.1, AA398622.1, AI374841.1, AI375548.1, AI394089.1, AA216389.1 , AI581299.1, AI921516.1, AI214404.1, AA150885.1, AI653196.1, AI203433.1, AW195686.1, C02893.1, AA554544.1 , AW089045.1, AA933956.1, AW629507.1, AA992949.1, AA705964.1, AI347250.1, AI637679.1, C05423.1, C04410.1, AA847971.1, AA229416.1, AW176737.1, HI 8558.1 , AWl 76739.1, AI694296.1, AW136263.1, AW085017.1 , C04272.1 , AI261738.1 , C05173.1 , AA382285.1 , AI521377.1 , AI424979.1 , A W663732.1 , A W339172.1 , AI942242.1, AI800325.1, AI375299.1, AI357116.1, AI093643.1, AI092542.1, AA814953.1, AA742275.1, AA449118.1, AA316997.1, W93827.1, AW085117.1, AA989453.1, AI810160.1, AI860878.1 , AA150777.1, H18451.1, AA779848.1, AA503492.1, AI480401.1, AA380917.1, AWl 19042.1 , AI950385.1, AI382337.1, AA808771.1, F05367.1, AA766240.1, T15871.1, AI472592.1, N84674.1, D56945.1 , AI696377.1, AW235470.1, AA828857.1, AA649140.1, AA936191.1 , AL048975.1, AI138753.1, F01619.1, AI478145.1, W93826.1, AW407620.1, AA082140.1, D56745.1, AI970145.1, T28290.1, AI761167.1 , AC023170.3, ACOl 1786.5, AC016293.2, AC022065.2, AP002006.1, AP001981.1, AL355293.2, ACOl 1389.5, AC009427.2, AC025903.1, AC016800.2, ACOl 1844.3, AC009070.5, AC009305.1, AC024306.3, AF206725.1, AC020893.4, AC025778.2, AC025277.2, AC019265.3, AL354877.2, ALl 38729.1 , AP000471.1 , AC067839.1, AC018519.3, AC044902.2, AC067966.2, AC021523.3, AC010735.3, AC004937.1, AL355871.1, AL353705.1, AL352977.1 , AL079307.4, AC031976.3, AC016856.3, AC024444.2, AC021 148.4, AC018360.7, AC023718.2. AL139014.3

SEQ ID NO: 522

ZH034/T3

NM_003201.1, M62810.1, AB014089.1, NM_009360.1, U63860.1, U63859.1, U63858.1, U57939.1, L07107.1, U35728.1,

AC016026.13, AC016025.12, AC007845.12, NC .001 138.1, AF135799.1 , U51994.1 , U05814.1 , D50617.1. D31600.1, L00602.1 , AC067967.2, NC .001 144.1, AC005309.2, AE003513.1, AE003490.1, AC002040.1, NM_005410.1 , AC005832.1, AF000657.1, U19027.1, AL161544.2, Z47073.1, AL132862.1, ALl 10502.1, Z83230.1, Z70781.1, AL022097.1 , Z97341.2, Z 1 1793.1 , AB005246.1 , A W269796.1 , AI928504.1 , AA 150885.1 , AA992949.1 , AW340722.1 , AW666007.1, AI769813.1, AI374841.1, AI375548.1, AW176737.1, AI581299.1, AI214404.1, AI203433.1, AA933956.1, AA758646.1, AA625849.1, AW176739.1, C05173.1, AW136263.1, AI862124.1, AA995790.1, AA382285.1, AI473739.1, AA554544.1 , AI950385.1 , AA705964.1, AW085017.1, AI472592.1 , AI347250.1 , AI394089.1 , AA398622.1, AI138753.1, AA828857.1, AA936191.1, AA150777.1, AI261738.1, AI694296.1, AI027655.1, AW360354.1, AA989453.1, AA837665.1 , AW303542.1, AI893658.1 , AI182485.1, AA939510.1, AA261330.1, AA041749.1, AI026148.1, AA879876.1, AW235470.1 , AV266273.1 , AI480401.1, AA028254.1, AW200061.1 , AI810160.1, AV045619.2, AA380917.1, AJ393272.1, AV044416.2, AI050306.1, AI021090.1, AA531437.1, W36799.1, W36911.1, AV440927.1, AW338019.1, AW337174.1 , AW269901.1, AW264523.1, AW244106.1, AW242955.1, AW130918.1, AW103736.1, AW020023.1, AI979233.1, AI925560.1, AI880823.1, AI799625.1, AI679731.1, AI632008.1, AI151234.1, AI024512.1 , AA988412.1 , AA977782.1, AA845625.1, AA843453.1, AA805646.1, AA716432.1, AA576243.1, AA506199.1, N78747.1, AC023170.3, ACOl 1786.5, AC022065.2, AP002006.1, AP001981.1, AL138729.1, AP000999.2, AP000802.1 , AC009188.4, AC067785.1, AC019169.3, AL158079.5, AL157946.2, AC046132.4, AC025035.5, AC016182.3, ACOl 1223.5, AC008945.3, AC068314.1, AC026653.2, AC040919.1, AC021561.3, AC024060.2, AC023812.3, AC013486.2, AC021808.3, AC005506.6, AC020751.2, AC018812.3, AC023633.1, AC023939.2, AC019315.2, AC015347.1, AC012877.1, AC005540.2, AC004060.1, AL139192.3, AL138901.2, Z94158.1, AL133473.4, AL022285.6, AP001845.1, AP001490.1, Z92820.1 SEQ ID NO: 523 ZH034/T7

NM_003201.1, M62810.1 , AL034386.2, AC009079.4, AC004695.1, AL022239.1, U91323.1, AL163304.2, AL031012.1, AP001759.1, AC008873.4, AC022073.13, AC007970.3, AL121586.28, NM_014362.1, AC009310.3, AE002743.1, AC007917.15, U66669.1 , AF01371 1.1, AF020932.1 , U73638.1, AL049712.12, AC006012.2, AC004991.1, AC007568.1, AC006010.2, AC007123.1, U14101.1, AL161532.2, AL132952.1 , AL078606.1, Z93018.1, AL035522.1, AB037120.1 , AB0371 19.1, AB013915.1, AB022126.1, ACOl 1362.2, NC_000895.1, AC009784.2, AC007041.3, AL163216.2, AL163205.2, AL139076.2, AL031674.1, Z99495.1, Z99708.1 , U67917.1 , U30821.1, AB000109.1, AP001671.1, AP001660.1, AP001347.1, AI694296.1, AI862124.1, AI394089.1, AI521377.1, AI424979.1, AW663732.1, AW339172.1, AI942242.1, AI800325.1 , AI473739.1 , AI375299.1, AI3571 16.1 , AI093643.1, AI092542.1 , AA814953.1, AA742275.1, AA449118.1, AA316997.1, W93827.1, AW0851 17.1, AI810160.1, AA989453.1, AI860878.1, H18451.1, AA779848.1,

AA380917.1 , AA503492.1 , AI928504.1 , AA995790.1 , AWl 19042.1 , AI480401.1 , AI261738.1 , AI347250.1 , AI382337.1 , AI769813.1, AA808771.1, AA766240.1, T15871.1, D56945.1, AA705964.1, AI696377.1 , AAl 50777.1, AA554544.1 , AA649140.1, AW235470.1, F01619.1, AW269796.1 , AW666007.1, AW085017.1, AI581299.1, AI375548.1, AI374841.1, AI478145.1, W93826.1 , D56745.1, AA082140.1, T28290.1 , AI026148.1 , AI761 167.1, AI669271.1, AA828857.1, AA936191.1, AI472592.1, AA642393.1, AA669592.1, AA102838.1, AA931943.1, AI029587.1, AI411675.1, AI103586.1 , AW614266.1, AW302221.1, AW243362.1, AI984813.1, AI927995.1, AV159002.1, AI768695.1, AI767426.1, AI743954.1, AI695241.1, AI691032.1 , AI569800.1 , AI554228.1 , AI470575.1 , AI375081.1 , AI076773.1 , AA835045.1 , AA243331.1 , AA102839.1, AV368179.1, AC023170.3, ACOl 1786.5, AC022065.2, AP002006.1, AP001981.1, AL355293.2, ACOl 1389.5, AC009427.2, AC025903.1 , ACOl 6800.2, ACOl 1844.3, AC009070.5, AC009305.1, AC022331.5, AF206725.1, AC008972.5, AC008515.5, AC025778.2, AC025277.2, AC027598.1 , ACOl 3607.3, AC020960.1, AL354877.2, AP000471.1, AC037443.2, AC067839.1, AC023857.2, AL096793.14, AC044902.2, AC067749.2, AC008728.4, AC005079.2, ACO 10087.3, AC034169.2, AC021523.3, AC004937.1, AL352977.1, AL161665.1, AC018700.3, AC020704.3, AC016186.3, AC023718.2, AC019245.2, AC018860.2, AC006714.2, ALO31823.10, AC046198.2, AC036199.2, AC019206.3, AC023137.2, AC040890.1, AC025708.3, AC024411.2, AC004688.6, AC004709.3, AL161796.3, AL353617.1, APOOl 109.1

SEQ ID NO: 524 ZH1312/T3

NM_003201.1 , M62810.1 , X64269.1 , NM_012251.1, AB014089.1 , NM_009360.1 , U63859.1 , U63858.1 , U57939.1 , L07107.1, U63860.1, AF125313.1 , AC013430.4, AC00791 1.8, AF089242.1, AL163276.2, ALl 17352.12, U71395.1,

U27809.1, AP001731.1, AP001438.1, AP001434.1, AP000162.1, AP000020.2, NC .001138.1, AC009478.4, AE003797.1, AC007627.3, AC007633.3, AF141883.1 , AF101268.1 , AE001696.1, AC003950.1, AC004806.1, AC005815.1 , U62306.1, AL355928.1, AL163255.2, AJ288911.1, AJ288910.1, AJ288909.1 , AJ288908.1, AL133162.2, AL161831.1, AL161540.2, AL161515.2, AL021069.1, AL031774.1, Z75208.1, Z97337.2, D50617.1, AP001710.1, X06180.1 , M37271.1, D00747.1, AP000208.1, AP000247.1, AP000130.1, AB020869.1, D31600.1, Z991 18.1, D10681.1, D10680.1, L00602.1 , AA449551.1, AW303542.1, AA102499.1, AI090110.1, AA216389.1, AI921516.1, AI653196.1, AW195686.1, C02893.1, AW089045.1, AW629507.1, AI637679.1, C05423.1, C04410.1 , AA398622.1, AA847971.1, AA229416.1, H18558.1, AW340722.1, AA625849.1 , C04272.1 , AA758646.1 , F05367.1, N84674.1 , AI214404.1 , AL048975.1, AI203433.1, AA933956.1 , AW407620.1, AI970145.1, AA393273.1, AW136263.1, AA382285.1, AW176737.1, AW176739.1, AL022880.1,

AI787961.1, AI786086.1, AI528469.1, AI324462.1, AA71 1556.1, AA517909.1, AA474993.1, W89803.1, AA028254.1, W62315.1, AA921601.1, AA522358.1, AA122613.1, AV213620.1, AWO 12804.1 , AA261330.1, AI138753.1, AW557486.1, AW554744.1 , AW553689.1 , AW344069.1 , AV263786.1 , AI437369.1 , AW756512.1 , A W756019.1, AW203407.1 , AW203346.1, AV338708.1, AI966444.1, AI726437.1, AI725235.1, AI670698.1, AI484148.1, ACOl 1786.5, AC023170.3, AC016293.2, AC022065.2, AP002006.1, AP001981.1, AC026307.7, ACOl 1214.2, AC009570.7, AC068063.2, AC024925.2, AC025429.2, AC016768.4, ACOl 1945.3, AC022827.2, AC020658.3, AC016397.4, AC015869.1, AC009709.4, ACOl 1953.2, AL138729.1, AC027613.2, AC012149.5, AC068788.3, AC055748.5, AC022224.19, AC068615.2, AC036121.2, AC048375.2, AC026731.3, AC037198.3, AC034268.2, AC022787.3, AC012258.3, AC017087.4, AC026612.2, AC021590.3, AC007601.2, AC023403.2, AC011632.3, ACOl 1733.4, AC019228.4, AC016732.2, AC012408.3, AC022865.2, AC008188.3, AC009863.2, AC018184.1, AC007644.1, AL355342.2, AL138825.3, AL355601.1, AL157400.1

SEQ ID NO: 525 ZH1312/T7 NM_003201.1, M62810.1, AL034386.2, AC009079.4, AC004695.1, AL022239.1, U91323.1, AL163304.2, AL031012.1, AP001759.1, AC008873.4, AC022073.13, AC007970.3, AL121586.28, NM_014362.1, AC009310.3, AE002743.1 , AC007917.15, U66669.1, AF013711.1, AF020932.1 , U73638.1, Z94044.1, M58484.1 , AC006012.2, AC004991.1, AC007568.1, AC007123.1 , U14101.1, AL161532.2, AL078606.1 , Z93018.1, AL035522.1, AB037120.1, AB037119.1, AB013915.1, AB022126.1, ACOl 1362.2, NC .000895.1, AC009784.2, AC007041.3, AL163216.2, AL163205.2, AL139076.2, Z7031 1.1, AL031674.1, Z99495.1, Z99708.1, U67917.1, AB000109.1, AP001671.1 , AP001660.1,

AP001347.1, AI694296.1, AI862124.1, AI394089.1, AI521377.1, AI424979.1, AW663732.1, AW339172.1, AI942242.1, AI800325.1 , AI473739.1, AI375299.1, AI357116.1, AI093643.1, AI092542.1, AA814953.1, AA742275.1, AA4491 18.1, AA316997.1, W93827.1, AA989453.1 , AW0851 17.1, AI810160.1, AI860878.1, AA380917.1, H18451.1, AA779848.1, AA503492.1 , AI928504.1 , AI480401.1, AA995790.1 , AWl 19042.1 , AI261738.1 , AI382337.1 , AI347250.1 , AI769813.1, AA808771.1, AA766240.1, T15871.1 , D56945.1, AA705964.1, AI696377.1 , AA150777.1, AA554544.1, AW235470.1, AA649140.1, F01619.1, AI478145.1, AW269796.1 , AW666007.1, AW085017.1, AI581299.1, AI375548.1, AI374841.1, W93826.1, AA082140.1 , D56745.1, T28290.1, AI026148.1, AI761167.1, AI669271.1, AA936191.1, AA828857.1, AI472592.1, AA642393.1, AA669592.1, AA102838.1, AI029587.1, AI411675.1, AI103586.1, AW6I4668.1, AW614266.1 , AW612554.1 , AW572783.1, AW270957.1, AW243362.1 , AI984813.1, AI823757.1, AI784606.1, AI695241.1, AI691032.1, AI470941.1, AI375081.1, AI287805.1 , AI217260.1 , AI051344.1 , AA888026.1 , AA815394.1 , AA628961.1, AAl 90577.1 , AV368179.1, AC023170.3, ACOl 1786.5, AC022065.2, AP002006.1, AP001981.1, AL355293.2, ACOl 1389.5, AC009427.2, AC025903.1 , ACO 16800.2, ACOl 1844.3, AC009070.5, AC009305.1, AC022331.5, AF206725.1, AC008972.5, AC008515.5, AC025778.2, AC025277.2, AC027598.1, AC013607.3, AC020960.1, AL354877.2, AP000471.1, AC037443.2, AC067839.1, AL096793.14, AC044902.2, AC067749.2, AC008728.4, AC005079.2, AC010087.3, AC034169.2, AC021523.3, AC004937.1, AL352977.1, AL161665.1, ACOl 8360.8, AC055841.2, AC018700.3, AC031976.3, AC023718.2, AC018860.2, AJ239319.3, AC046198.2, AC036199.2, AC019206.3, AC023137.2, AC040890.1, AC025708.3, AC024411.2, AC019007.3, AC004688.6, ACOl 1566.3, AC023942.2, AC004709.3, AL160261.4, AL161796.3, AL353617.1, AL136298.1 SEQ ID NO: 526 ZH1386 T3

NM_014890.1, U53445.1, AC004020.1, AE003832.1, AC012039.10, Z82203.1, X52075.1, M61827.1, AC011456.2, AE003629.1, AC004595.1, AF104477.1, AC005547.1, U60149.1, AF003530.1, AC000403.1, AL079304.2, AL096867.15, Z82268.1 , AL049692.13, AJOl 1002.1, M32612.1 , AF166025.1, AF130358.2, AC008166.2, AC004021.1, AC015985.8, AC007560.3, AC004125.1, AC005046.3, U41274.1, AF130342.1, L14323.2, AFl 12922.1, U85714.1, U85713.1,

U85712.1, AF098991.1, M57500.1 , U53325.1, AC003070.1, AL163206.2, AL078459.8, AL035458.35, AL021807.1, AL022717.1 , Z82899.1 , AL096769.7, U64852.1 , X 15742.1 , M26915.1, M20636.1 , AB020865.1 , M 13798.1 , M96739.1 , AW867011.1, AI642381.1 , AW779584.1, AW779590.1, AW779587.1 , AA611335.1, C05084.1, AI606223.1, AW779641.1, AV292155.1, AA611336.1, AI549138.1 , AI554667.1, AI553756.1, AI402221.1, AI202123.1, AI084203.1, AI614167.1 , C55082.1 , AA497874.1, AA196522.1, AW871954.1, AW208053.2, AW459498.1 , AW439057.1, AV369587.1, AV339384.1, AV259982.1, AV245839.1, AW076711.1, AI733300.1, AI733105.1, AA910905.1 , AA623952.1, AA537555.1, AA387953.1 , AA386853.1 , AA274292.1, H09936.1, AC022883.3, AC024938.7, AC069222.1, AC010324.4, AC009086.4, AC023831.3, AC025231.2, AC007330.5, AC015178.1, AC010696.2, AL161632.4, AL158145.4, AL132989.1, AL157819.2, AC048376.2, AC058820.2, AC022263.4, AC004906.2, AC053533.1, AC027233.2, AC012056.3, AC026536.1, AC023613.1, AC014353.1, U82207.1, AL353632.4, AL136380.2, AL162389.3, ALl 18524.25, AC055879.2, AF267167.1, AC009794.3, AC013808.3, AC021114.3, AC024353.2, AC017103.3, AL355352.3, AL137016.10, Z82191.1, AP001026.1

SEQ ID NO: 527 ZH1386/T7

NMJH4890.1, U53445.1, L16887.1 , AC009294.8, AB005241.1, AE003474.1 , AE003418.1, AC004885.2, AC010175.4, AC004061.1, AL031583.2, AF096863.1, AF 132287.1 , AC022492.5, AE003811.1, AC007843.6, U91323.1 , AC007630.3, AF099917.1, AL158088.6, AL034399.6, U49947.1, X95276.1, AJ007556.1, AI435598.1, AI810391.1, AI435391.1, AW303392.1, AI921737.1, AI401231.1, AA576134.1 , AI635663.1, AA424880.1, AI016121.1, AW058260.1,

AW026643.1, AI817224.1, AI139164.1, AI086061.1, D57964.1, AI185109.1, AA430212.I , AW295168.1, AA973230.1, AA609225.1, AW058427.1 , AA857729.1 , AI394490.1, AI783720.1, AI378381.1, AI334138.1, AI701330.1, AW083745.1 , AI335721.1, AI378578.1, AI431237.1, AI804232.1 , W69790.1, AI803115.1, AWl 18656.1, AA033582.1, AA258605.1, AI013647.1, AW413495.1 , AA463851.1, AI371463.1, AA033581.1, AA925088.1, AA795013.1, AA256689.1, AI381752.1, F27521.1, R78245.1, AA568101.1, AA030472.1, D58330.1, D57334.1 , AA710489.1, AA241058.1 , D57996.1,

AA217400.1, AA445957.1, C16405.1, C16415.1, AI473313.1, AW363711.1 , AW346548.1, Z21882.1, AA891483.1, F37351.1, AA986888.1 , AA432784.1, AA266373.1, AA204051.1, AW582813.1, AI464359.1, AW214616.1, AV234619.1, AV248227.1, T84055.1, AW437163.1 , AAl 70494.1, AW363682.1, AV229961.1, AA255796.1, AA463341.1, AV343730.1, AA515391.1, AA546804.1, AA930120.1, AI181464.1, AA 172829.1, AI258437.1, AJ280472.1, AW373694.1, AV203822.1, AA570905.1, D66306.1 , AC069222.1, AC022883.3, AC024938.7, AC023911.4, AC012512.2, AC026770.3, AC020685.3, AC025666.2, AC026813.1, AC010014.5, AC014946.1, AC020107.1, AC010015.3, AL354827.1, AC018361.7, AC018473.10, AC044869.2, AC068725.1, AC010628.3, AC068595.1, AC026452.4, AC012321.4, AC009032.5, AC068055.1, AC027301.3, AC021537.3, AC023549.2, AC009635.4, AC012580.3, AC016130.13, AC018432.4, AC024007.2, AC024006.2, AC008342.11 , AC018361.6, AC017903.1, AC009598.2, AC008004.4, AC009741.4, AL355315.2, AL356272.1 , ALl 61632.4, AL354710.2, AL354669.1, AL161434.3, AL160274.2, AL158143.1, AL158063.1 , AP000904.2, AP001829.1, AP000706.1

SEQ ID NO: 528 ZH1394 T3 NM_015642.1, AL050276.1, AF194030.1, AF185576.1, AL121985.13, NM_006585.1 , AC006972.2, AC006384.2,

AF177669.1, AC004828.2, AC007052.4, AC005144.1, AL355736.1, AL163249.2, Z68161.1, AJ251713.1, AJ251712.1, AL033538.1, AL035415.22, Z68332.1, AL035073.4, D42052.1, D13627.1, AW502748.1, AA578163.1, AA069836.1, AW237166.1, H85064.1, AW611145.1, AW106649.1, AI828036.1, AI221632.1, AA464297.1, AI151799.1, AW673083.1, AW618417.1, AW362358.1, AW362276.1, AW362252.1, AW247278.1, AW213355.1, AI648841.1, AI641856.1, AA984168.1, AA871508.1, AA385412.1, AA347604.1, H88667.1 , AC027493.2, AC069063.1 , AC026560.4, AC055739.2, AC025358.3, AC036131.2, AC041009.1, AC034154.1, AC027790.1, AC012056.3, AC024606.2, AC021712.3, AC022736.2, AL161444.2, AP001959.1, AC069102.1, AC068656.1, AC025763.2, AC027082.2, ACOl 1741.3, AL137021.3, AL136990.14, AC024935.8, AC025028.8, AC036153.2, AC046168.2, AC016481.4, AC020930.4, AC008939.3, AC008839.4, AC036127.2, AC037456.4, AC022218.4, AC034167.2, AC026542.2, ACOl 1026.3, AC021506.3, AC034119.1, AC018943.4, ACOl 1175.4, ACOl 1853.3, AC012571.3, AC015474.3, AC025009.2, AC009899.5, AC020588.4, AC013817.4, ACOl 1642.5, AC023103.3, AC024340.1, AC015950.2, AC017056.3, AC021047.2, AC019648.1, AC015579.2, AC015675.1, AC007432.7, AC009437.1, AF129075.1, AC002355.1, AL356137.2, AL356322.1, AL162716.4, AL160265.4, AL355386.1, AL354778.1 , AL137074.4, AC002099.1 , AL158826.2, AP001841.1, AP001569.1, AP001365.1, AP001356.1, AP001095.2

SEQ ID NO: 529

ZH1394/T7

NM_015642.1, AL050276.1, AF194030.1, AF185576.1, AC008372.6, AC005874.3, AC007766.1, AF134471.1 , D88148.1,

AE003835.1, AC007225.2, AL133258.16, AL163225.2, AL135858.2, AL034559.3, Z96810.1 , APOO 1680.1, APOOl 138.2, AA834935.1 , AW293260.1, AI798849.1, AI240155.1, AA083812.1, N26227.1, AA930334.1, AI809178.1 , AA828063.1, AA943003.1, AW108541.1, AI551088.1, AI626969.1 , AI445139.1, N71750.1, N99462.1, AV028027.1, AI809910.1 , AA613636.1, AV137484.1, AV329304.1, AV329353.1, AV330564.1, AI610886.1, T12777.1, AWl 15543.1, AA544682.1, AA472454.1, AA465787.1, AAl 19039.1, AA024136.1, W29276.1, R93225.1, H02904.1, AW772943.1, AW489077.1, AC068938.1, AC016803.2, AC068072.7, AC025676.2, AC021032.3, AC068659.1, AC010374.4, AC036186.2, AC010287.5, AC009164.3, AC009130.5, AC009093.5, AC008758.3, AC027250.2, AC046150.2, AC024721.4, AC007615.3, AC021792.2, AC025394.2, AC0121 11.3, AC009270.2, AC015958.3, AC017038.5, AC023980.2, AC010583.3, AC022023.2, AC018792.2, ACOl 1279.1, AL157833.5, AL136172.14, AL355594.3, AL135903.2, AL033383.25, AL158014.4, AL160280.2, AL157827.3, AL137848.1, AL138831.2, AL157883.2, AL136309.3, AL133461.2, AP001780.1, AP000853.1, AP000580.2, AC012520.8, AC046140.4, AC026763.5, AC048337.4, AC068972.1, AC067852.1, AC020903.3, AC008699.4, AC027810.2, AC025875.3, AC068382.1, AC021443.5, AC026938.2, AC022715.2, AC021369.3, AC024883.3, AC025311.2, AC019313.3, AC024619.2, AC020372.1, AC012281.1 , AC007896.1, AL356289.2, AL096855.24, AL354934.1, AL139806.3, ALl 58058.1 , ALl 39427.1, AL136095.4, AP000874.1 SEQ ID NO: 530 ZH1401/T3

AF005067.1, AL080149.1 , Z98885.1, X64746.1, X64745.1, AF203193.1, AF203192.1, AF203160.1, AF203138.1 , AF203137.1 , AF203118.1 , AF129334.1 , U37269.1 , U37268.1 , AF064681.1, AF064680.1 , AF064679.1 , AF064678.1 , U23487.1, AK000751.1, AB0331 12.1, M58271.1, M58270.1, M58269.1, M58268.1, M58267.1, M58266.1, M58265.1, M58264.1 , M58263.1 , M58262.1 , M58261.1, M58260.1 , M58259.1 , M58258.1 , M58257.1 , M58256.1 , M58255.1 , M58254.1 , M58251.1, M58212.1, M58207.1 , M58200.1 , M58194.1, M58186.1, M58183.1, M58179.1 , AF203182.1, AFl 10401.1, U27443.1, AF066970.1, NM_006751.1, AF203140.1, AF203139.1, AF203122.1 , AF203120.1, AF2031 19.1 , AF174703.1, AF174702.1, AF174701.1, AF174700.1, AF174699.1, AF174698.1, AF174697.1, AF174696.1, AF174694.1, AF174693.1, AF174692.1, AF079325.1 , AF120917.1, AF120916.1 , AF120915.1, AF120914.1, AF120913.1, AF120912.1 , AF120909.1, AF129381.1, U03340.1, U03338.1 , U84848.1, U84811.1, AF029776.1, AF082358.1 , AL035703.20, AL022103.1. M61199.1 , Zl 1812.1, U16868.1, U16866.1, U16864.1, AJ233022.1, AJ233020.1, L15492.1, L15491.1, L15490.1, L15489.1, AL040577.1, AW408719.1, AL041903.1, AA340707.1, H11686.1, M79139.1, HI 1889.1, AJ397954.1 , AA759003.1 , AW752395.1 , AW375924.1 , AL047827.1 , AI514970.1 , AA990859.1 , AA948792.1 , AA428908.1, AA325161.1, AA187577.1, AA158452.1, AA045603.1, AW598032.1, AW410598.1, AW289794.1,

AV391484.1, AW047869.1, AI969973.1, AI948717.1, AI710520.1 , AI705195.1, AI499756.1, AI454951.1, AI029325.1, AA859441.1, AI263045.1 , Al 175427.1 , Al 175396.1 , Al 170788.1 , Al 103955.1 , AI076494.1 , AI076474.1 , AA843382.1 , AA448354.1, AL160033.6, AL162499.3, AC020909.4, AL079336.13, AL138703.2, AC010789.8, AC048356.2, AC024591.2, AC009108.6, AC023592.2, AC025929.2, AC021769.3, AC016774.2, AC020962.1, AC009962.3, AC007328.4, AC020260.1, AL354919.5, AL133420.24, AL138809.14, AL139160.1, AC013251.7, AC010177.4, AC026765.5, AC068785.4, AC021 151.6, AC023524.4, AC025862.2, AC022559.3, AC013614.4, AC016841.2, AC015844.4, AC013562.3, AC012109.2, AC018699.2, AC012354.3, AC018758.1, AC016246.1, AC013590.1, AL139384.3, AL355372.2, AL162711.4, AL355804.2, AP001007.1, Y12335.1 SEQ ID NO: 531 ZH1401 T7

AF005067.1, AL049402.1, Z98885.1 , AL080149.1, AJ276620.1 , Z77661.1, AC010143.3, AE003520.1, AE001419.1, AC004186.1, Z98551.1, AL137226.2, AL139165.1, AL031407.3, AP000517.1, AB023055.1, AB023054.1, AC008082.12, AC005293.1, AC002984.1, AL163231.2, Z97348.1, ALl 17204.1, AL137082.1 , AP001686.1, AI912611.1, AA194257.1, AW511409.1 , AI350842.1, AI497969.1 , AI991928.1, AW367919.1 , AI061156.1, AI697635.1, AA744999.1, D53392.1, HI 1244.1, AI680322.1 , T07017.1, AU021249.1, AW464067.1, AA675465.1, AU021226.1, H07921.1, AA675514.1, AA096761.1, AI316859.1, AA675570.1 , HI 1599.1, AA415581.1, AI605086.1, AA140518.1, AA407537.1, AA423260.1, L26667.1, AV232516.1 , AV308339.1, AI136270.1, AV362645.1, AV232046.1 , AV221817.1, AV309058.1, AA538272.1, AV295672.1, AA881466.1, AI909924.1 , AV317023.1, AI610452.1 , AV272219.1, AA253945.1 , D81299.1, AA163258.1, AW151974.1, AA267651.1, D25843.1, AV362354.1 , AA602506.1. N55893.1 , T60706.1, AW556255.1 , AW542024.1, AW537016.1, AV289834.1, AV289382.1 , AV289178.1, AV288814.1, AV224618.1, AV139922.1, AV137850.1 , AV046737.2, AV035033.1, AV019927.1, AV004214.1, AV004049.1, AI646744.1, AI504196.1 , AU045405.1, AI195953.1, Al 194930.1 , AH 74039.1 , Al 118360.1 , AUO 18650.1 , AU017925.1 , C87705.1 , C85970.1 , AA213332.1 , AC026436.2, AC024518.2, AL355335.2, AC018613.3, AL355821.3, AL356099.1, AC017268.1, AC008225.2, AC008029.2, AC016938.3, AC023406.2, AC021184.2, AC019498.1, AP001274.1, AC069202.1 , AC022081.1 1, AC008517.4, AC007383.3, AC022738.3, AC004688.6, AC019213.4, AF215845.1 , AC019247.3, AC004709.3, AL121920.11, AL353748.1

SEQ ID NO: 532 ZH146/T3

NM_002810.1, U24704.1, U51007.1, NM_008951.1, AF013099.1, U72664.1, AB017188.1, NM H5887.1, AF050199.1, AL163271.2, AP001726.1, AP000695.1, AE003594.1 , AFl 32175.1, S79502.1 , AC004682.1 , AC007887.8, AL161533.2, AL049638.1 , AC024744.1, AC007199.1 , M37839.2, AF040660.1, AF028594.1, AL163265.2, AL032623.1, AL080316.8, AC000124.1, AJ249712.2, Z96104.1, L36818.1, AP001720.1, X76775.1 , X87344.1, AB030580.1, L24444.1, AP000169.1 , AP000054.1, AP000326.1, AP000122.1, AW673436.1, AW672767.1, AL038646.1 , AW673418.1, AW248977.1, AI879204.1 , AW249106.1, AA579150.1 , AL044248.1, AW673459.1, AA308484.1, AA171439.1, AW659167.1, AW656822.1 , AW655068.1 , AA305222.1 , AA082806.1 , H83202.1 , AA204750.1 , AA316542.1 , AA307459.1 , AW230957.1 , AA304882.1 , AIOl 4833.1 , AA510737.1 , AW478534.1 , AA869524.1 , AA378571.1 , AA338888.1 , AA221171.1 , AI593123.1, AA500712.1 , D31409.1, AA230745.1, AA396511.1, AA351328.1, H24730.1, AW405232.1, AA792589.1, AA756197.1 , AA413708.1, W98705.1, AW407152.1, AA571568.1, AA351224.1, AA237807.1,

AA095807.1, D30928.1, AW298845.1, AA193157.1, W29295.1, C84560.1, AA544200.1, AA212988.1, AW494135.1, AA450618.1 , AAl 73808.1, AW229742.1, AA004048.1, AA590904.1, AA675428.1, AW238959.1, W05271.1, AA623538.1 , AA623582.1, AW797533.1, AW446745.1, R58821.1, C02139.1, AA537242.1, R74699.1, R74648.1, Z24793.1, W98493.1, AW280558.1, AW305568.1, AW280521.1, AA222858.1 , AI957972.1, ALl 18454.1, AW233195.1, AI497266.1, AA352114.1, AA780170.1, AW158597.1, AA982659.1, AI497229.1, AA637331.1, AI980403.1, T30391.1, R95474.1, AW643627.1, AA617293.1, AA607817.1, W78781.1, AI056400.1, AI090158.1, AA607118.1, AA210395.1, AA855077.1, AC009564.4, AC000005.1, AC024074.3, AC017581.1, AC009075.5, AC051656.2, AC022632.3, AC021964.1, AP000408.2, AC020877.2, AC025426.2, AP000758.1, AC016955.9, AC012496.4, ACOl 1086.4, AC026421.2, AC016629.5, ACOl 1505.3, AC032039.1, AC012063.2, AC023036.1, AC022094.1, ACOl 1286.4, AC006704.1, AL132640.1, AL031011.20, AP000932.2, AP000844.1, AP000800.1, Z95393.1

SEQ ID NO: 533

ZH 147/T3

AL163266.2, AP001721.1, AP000171.1, AP000057.1, AP000330.1 , AP000125.1, D43969.1, D43968.1, X90976.1, D26531.1, AFl 16587.1, AL163229.2, ALl 17202.1, AP001684.1, AP000959.2, Z97348.1 , AL035470.7, AC004747.2, AE003811.1 , AE003548.I , AE003503.1, AE002760.1, AE003194.1 , AC006986.2, AC016831.1, AFl 16027.1, AE000597.1, AC006313.1, AC006198.1 , AF096373.1, AF017104.1 , AF034976.1 , AC004766.1, AC004629.1, AF044870.1, AF044869.1, U82375.1, AL161517.2, AL161516.2, AL078463.1 1, Z83236.1, AL096763.14, AL096699.11 , Z68134.1 , Z71266.1 , AL022313.1 , AL079338.15, AL034552.22, AL049488.1 , AL049481.1, AB006700.1 , AJ228191.1, AI798056.1 , W25586.1, AI323622.1, AA125379.1 , AW609213.1, AA851955.1, AA210262.1 , AI542974.1, N98022.1, AW807912.1, AW807845.1, AW807823.1, AW807767.1, AW807668.1, AW618125.1, AL138351.1, AW218206.1, AV292256.1 , AW043002.1 , AI919833.1, AA956689.1, AA945982.1, AA806582.1, AA610907.1, F12673.1. T74354.1, ACOl 1257.3, AC021619.3, AC013300.2, AC068863.1, AC026607.2, AC008076.8, Z92854.1 , AC069133.1, AC012435.6, AC036214.2, AC009054.4, AC068374.1, AC058806.1, AC016879.4, AC022248.2, AC024535.2, AC006278.6, AC022620.1 , AC016495.1 , AL354894.1 , AP001593.1, AC010621.3, AC016323.4, AC026850.2, AC019345.3, AC021385.3, AC005505.6, AC022888.2, AC022940.1, AC009580.2, ACOl 1149.1, AC005139.3, AC005586.1, AL109844.3, AL354698.2. AL353774.1 SEQ ID NO: 534 ZH147/T7

ACOl 1257.3, AC021619.3, AC013300.2, AC068863.1, AC026607.2, AC008076.8, Z92854.1, AC069133.1, AC012435.6, AC036214.2, AC009054.4, AC068374.1, AC058806.1, AC016879.4, AC022248.2, AC024535.2, AC006278.6, AC022620.1 , ACOl 6495.1, AL354894.1, AP001593.1, AC010621.3, AC016323.4, AC026850.2, AC019345.3, AC021385.3, AC005505.6, AC022888.2, AC022940.1, AC009580.2, ACOl 1 149.1, AC005139.3, AC005586.1,

AL109844.3, AL354698.2, AL353774.1, AW170035.1 , AA808812.1, N59527.1, AA225759.1, AA766310.1, AL134398.1, D57390.1, AI638711.1 , AI580781.1, AW043680.1, AA664700.1 , F00440.1, AI914872.1, AI821400.1, AI287627.1, AI287541.1, AI284640.1, AI024030.1 , AW872676.1 , AW473163.1, AI972203.1, AI817516.1, AI355556.1, AI085719.1, AI766275.1 , AA330322.1, AI633942.1, AW089625.1, AW071163.1, AA224525.1, AA137274.1 , AW600804.1, AI819574.1, AA737432.1, AA459749.1 , AW022897.1, AA810438.1, AW179028.1, AI632259.1, W70188.1 , AI963266.1, AI924251.1, AI791819.1, AA229609.1, AA228418.1, AA228330.1, T41259.1, AA593471.1, AA524821.1, AA128899.1, W68497.1, W68362.1, AW50363I .1, AA815052.1, AA 179944.1 , N99939.1, AW440545.1, AI004704.1, AA831 132.1, AA630637.1, AA309530.1, AA112239.1, AA015649.1 , AW504554.1, AW087945.1, AI821596.1 , AI351599.1, AA593752.1, AA449661.1 , AA404541.1, AW138732.1, AW088224.1 , AW080062.1, AL037632.3, AW008089.1, AI952885.1, AI792213.1, AI733504.1, AI004333.1, AA601157.1, AI129968.1, AI038990.1, AI890888.1, AL048969.1, AI568862.1, AI307372.1, AI014358.1, AA722372.1, AA658844.1 , AA290563.1, AI057103.1, AI791664.1, U51702.1, T70713.1, AW408643.1, AI354862.1, AI313042.1, AA287570.1, AA634830.1, H96249.1, AW170035.1, AA808812.1, N59527.1 , AA225759.1 , AA766310.1 , ALl 34398.1 , D57390.1 , AI63871 1.1, AI580781.1 , A W043680.1 , AA664700.1 , F00440.1, AI914872.1, AI821400.1 , AI287627.1, AI287541.1, AI284640.1 , AI024030.1, AW872676.1 , AW473163.1, AI972203.1, AI817516.1, AI355556.1, AI085719.1, AI766275.1, AA330322.1, AI633942.1 , AW089625.1, AW071 163.1, AA224525.1, AA137274.1, AW600804.1, AI819574.1, AA737432.1, AA459749.1, AW022897.1, AA810438.1, AWl 79028.1 , AI632259.1 , W70188.1 , AI963266.1 , AI924251.1, AI791819.1 , AA229609.1 , AA228418.1 , AA228330.1 , T41259.1, AA593471.1 , AA524821.1, AA128899.1, W68497.1, W68362.1, AW503631.1, AA815052.1 , AA179944.1, N99939.1, AW440545.1, AI004704.1, AA831132.1 , AA630637.1, AA309530.1 , AAl 12239.1, AAO 15649.1, AW504554.1, AW087945.1 , AI821596.1, AI351599.1, AA593752.1, AA449661.1, AA404541.1, AWl 38732.1, AW088224.1,

AW080062.1, AL037632.3, AW008089.1, AI952885.1, AI792213.1, AI733504.1, AI004333.1, AA601 157.1 , AH 29968.1, AI038990.1 , AI890888.1, AL048969.1, AI568862.1 , AI307372.1, AI014358.1, AA722372.1, AA658844.1, AA290563.1, AI057103.1, AI791664.1, U51702.1, T70713.1, AW408643.1, AI354862.1, AI313042.1, AA287570.1 , AA634830.1, H96249.1,

SEQ ID NO: 535

ZH167/T3

NM_001722.1 , M17754.1, Z97214.1, Z77852.1, AP000495.1 , AC006559.6, AF054584.1 , M59454.1, AE003619.1,

Z75744.2, AJ000330.1 , Z92524.1 , AC008860.6, AE003639.1 , AE003626.1 , NM_013102.1 , NM_007361.1 , NM_008019.1, AC010206.8, AC008119.6, AF069772.1, AF121253.1 , AC005252.1, U48473.1, AC005186.1, AC005368.1, AC005135.1, AL080286.16, Z54146.1, AL031656.10, AL035688.8, U65101.1, U65097.1, U20523.1, Z95274.1, X15209.1, X15750.1, U26425.1, X60203.1, AB009778.1, J05200.1, AK000956.1, D16478.1, AJ223500.1, Y15170.1, D86641.1, D86425.1, AA190974.1, AI594912.1, AA059622.1 , AL040283.1 , AAl 10907.1, W46471.1, AI386232.1, AA122727.1, AA399844.1, AI326828.1, AI322682.1, AA048220.1, AW003894.1, AW258382.1, AW476686.1, AV399222.1, AW644870.1, AA834121.1, AA794714.1 , AA717337.1, D74157.1, D73725.1 , D73628.1, D68884.1, AW823309.1 , AW542250.1, AW532772.1, AW525852.1 , AW52031 1.1, AW435345.1, AW414137.1, AW413822.1, AW253719.1, AW253092.1, AV289217.1 , AV256080.1 , AV383396.1 , AWl 11251.1 , AW048811.1, AW046486.1 , AW044968.1 , AI946809.1 , AI945207.1 , AI893330.1, AI846539.1, AI836092.1, AI786376.1, AI786350.1, AV098966.1, AI764417.1, AI703598.1, AV037764.1, AV013891.1 , AV007174.1, AV001383.1, AV000652.1 , AI648905.1, AI575993.1 , AU051376.1, AA900458.1, AA859712.1, AI324138.1, AI303590.1 , AI256542.1, AI240294.1, AI179661.1, AH55734.1, AH23022.1 , AI105423.1, AA800240.1, AA800189.1, AA690461.1, AA608505.1, AA408052.1, AA271498.1, AA241272.1, AA210454.1, AA161957.1, AA141162.1 , AA048258.1, Z46979.1, AC012046.5, AC025669.2, AC013537.2, AC023257.2, AC069073.2, AC016450.4, AC015686.2, AL354921.1, AL157761.1, AC025715.1, AC020617.2, AC015047.1, AC008185.2, AC006892.2, AC006745.1, AL355531.1, AC044879.2, AC023497.9, AC022508.6, AC036174.2, AC025444.3, AC022098.5, ACOl 1469.5, AC008947.5, AC008781.4, AC008439.3, AC068039.2, AC027619.2, AC022454.8, AC018990.4, AC025144.2, AC025872.2, AC015916.3, ACOl 1864.3, AC015854.3, AC010020.5, AC014147.1 , AC020170.1 , AC009340.3, AC009744.6, AC010934.2, AC004689.5, AL157836.4, AL356131.2, AL162497.7, AL121827.11, AL163545.4, AL158068.4, ALl 18557.1, AL139396.1,

SEQ ID NO: 536

ZH167/T7

NM_001722.1, M17754.1, AC000097.1, AC005664.2, AC006547.9, AC000083.1, NC_001 142.1, AC012467.9,

AE003525.1 , AC009247.11 , AC006441.13, AC004468.1 , AF091342.1 , ALl 35978.2, X70810.1 , AL023775.1 , Z49501.1 , X87611.1, X17191.1, AE003718.1, AC018633.2, AF054589.1, AC004458.1, AC008115.3, AC007459.1, AC007015.1,

AFOl 1889.1, U19874.1, AC005391.1, AC005273.1 , AL138996.2, ALl 10195.1, AL049698.3, AL031123.14, AL023802.1, Z81030.1, Z68885.1, AL096838.1, AL022150.1, ALl 17391.1, AJ007747.1, X02732.1, U28153.1, AB032359.1, APOOl 111.1, AB016897.1, M20128.1, K03233.1, AB012132.1, AB011399.1 , AB006909.1, AW245980.1, AW476213.1, AA563702.1, AW003894.1, AI148206.1, Al 199590.1 , Al 199679.1, AA161400.1, AI499840.1, AA191442.1, AI691087.1, AA921302.1, AA449191.1 , W46389.1, AW087918.1, AI056425.1, AA143049.1, AI245821.1, AI079110.1, AW476686.1, AW173136.1, AA143248.1, AW087753.1 , AA664376.1, AI971276.1, AW780086.1 , A1262737.1, AW088799.1, D53315.1, AI890991.1, AI940628.1, AW062876.1, W46471.1, AA937731.1 , AA993377.1, AI919573.1, AA449190.1, AI498580.1, AW484249.1, AW434617.1, AW325394.1, AW314829.1, AA858776.1, AI009362.1, AI171406.1, AI105441.1, AA850668.1, AI600174.1, AW519712.1, AW491400.1, AW489084.1, AI662711.1, AI386232.1, AI326828.1, AI326118.1, AI322682.1, AA399844.1, AA268312.1, AA048220.1, AI170591.1, AA916521.1, AW610643.1, AI196133.1,

AW824654.1, AW778759.1, AW628131.1 , AW518437.1, AW291802.1, AI937742.1, AI910476.1, AI769417.1, F36565.1, F30370.1, AI565220.1, AI505161.1, AI347259.1, AI271998.1, AI228232.1, AI198686.1, AA992357.1, AA960836.1, AA926927.1, AA909034.1, AA828329.1, AA827915.1, AA796746.1, AA748774.1, AA587713.1, AA416606.1, AA389924.1 , AA278811.1, D44667.1, N49551.1, N49308.1, N46431.1, R82432.1, AC012046.5, AC025669.2, AC027311.2, AC016150.5, ACOl 1987.3, AC016263.3, AC019147.3, ACOl 1568.3, AC022573.2, AL157836.4, AL354698.2, AL161647.5, AL157379.3, AL139340.5, AL355599.2, AL162234.3, AL353757.1, AC010590.4, AC008761.3, AC015925.3, AC025316.2, AC022875.2, AC015724.4, AC022234.2, AC018841.2, AC022374.1, AL133347.6, AC040973.2, AC024189.3, AC027068.2, AC026583.2, AC013337.5, AC023204.1, AC012976.1, AC068545.2, AC067951.3, AC068660.1, ACOl 1475.5, AC010458.4, ACOl 1461.2, AC026949.2, AC021887.3, AC020740.4, AC009222.2, AF248716.1 , AC021814.2, AC026471.1, AC020565.4, AC023361.3, AC021060.8, AC007804.5, AL136361.3, AL139255.1

SEQ ID NO:537 ZH181/T3 AL137532.1, AB029032.1, AE003497.1, AB024035.1, AC002352.1, AJ243957.1 , M92280.1 , AP000003.1, Z46773.1, AA385836.1, AW270215.1 , AU066952.1, AW430391.1, AI615452.1, AA553056.1, AI044242.1, AW339333.1, AW199U2.1, AA818999.1, AI180338.1, AA575239.1, R57867.1, AC022489.3, AP000484.2, AC015416.1, AL355481.2, AC060830.3, AC026726.3, AC036111.2, AC020549.3, AC031977.3, AC037465.1, AC021320.3, AC027369.1, AC021037.4, AC021488.3, AC023753.5, AC009923.3, AC018510.3, AC012044.4, AC016532.2, ACOl 1829.2, AC016499.1 , AC002353.1, AL354894.1, AL139399.1, AP002000.1, AP000450.2

SEQ ID NO: 538

ZH181/T7

AB029032.1, AL137532.1 , AC003075.1, AFl 10420.1, AC000110.1, AL031643.1, AC005587.1, AC006227.1, Y09929.1, Y07645.1, AE003540.1, AC005292.4, U39995.1, AC002996.1, AL136039.2, AL161517.2, Z70312.1, Zl 1126.1, Z98755.1, AL049523.1, ABOl 6873.1, AW608977.1, AA478663.1, AI332836.1, AW613209.1, AI690447.1 , AI568320.1, AA130075.1, AW297346.1, AA211783.1, AW337781.1, R61516.1, T23481.1, AI860067.1, AI580679.1, AI076751.1, AA960940.1, R76699.1, D61837.1, AA479203.1, AA029329.1, H16598.1, AA250974.1 , AI925777.1 , AA603423.1, A1221611.1, T16483.1, D62007.1, R42735.1, T16667.1, R37151.1, AW381386.1, AW020319.1 , D62171.1, AW381401.1, AA724627.1, D59415.1, AW311719.1, AA862732.1, H13558.1, AA862731.1 , R23086.1, AI010238.1, AW436334.1 ,

AI875668.1, AI649360.1, AI504358.1, AJ392892.1, AI790295.1, AI853026.1, AW521 101.1 , AA924446.1, AA924003.1, AV368842.1, AW522536.1, AV335603.1, AW824580.1, AW540445.1, AW494950.1, AV338236.1 , AV313663.1, AV271828.1, AV271030.1, AV270109.1, AV259717.1, AV254619.1, AV229042.1, AI800388.1, AI765324.1, AI646211.1, AI645590.1 , AI643880.1, AI570172.1, AI451201.1, AI448335.1, AI394853.1 , AI368204.1, AA756342.1, AA527645.1, AA395949.1, AA217324.1, AA198502.1, AA163260.1, AW503085.1, AV339275.1, AU073033.1, AU072942.1, AI592797.1, AI381371.1, AI345559.1, AI247533.1, AI122002.1, R59960.1, R45176.1, AC022489.3, ACOl 1123.4, AP001460.2, AP001562.1, AC010470.4, AC024176.4, AC027519.2, AC069127.1, AC027321.2, AC027303.2, AC012312.4, AC008932.4, AC008534.3, AC027239.2, AC021546.3, AC031999.1 , ACOl 1205.3, AC064858.1, AC036229.1, AC019202.3, AC061986.2, AC018764.4, AC027780.2, AC010142.3, AC021364.3, AC018961.3, AC024325.2, AC009985.5, AL355980.2, AL139136.3, AL353734.3, AL354955.1, AL162375.4

SEQ ID NO: 539

ZH182/T3

NM_002465.1, X73114.1, X66276.1, U38949.1, D43697.1, NM_005683.1, AF216829.1 , AF174036.1, AF174022.1, AF174013.1, AF096786.1 , AF064879.1 , AF013626.1, AF013621.1, AF013619.1, AF013616.1, AF062278.1, AF062220.1, AF062207.1, AF062204.1, AF062203.1, AF062201.1, AF062149.1, U57564.1, U86524.1, U86523.1, AJ234257.1, AJ234190.1, AJ234189.1, AJ234187.1, AJ234160.1, S55017.1, L38425.1, U24688.1, U24683.1, Z82892.1, Z82875.1, X62112.1, Z47221.1, Y08303.1, Z14241.1, Z14240.1, Z14238.1, Z14239.1, Z14237.1, Z14235.1, Z14236.1, Z75396.1, Z75390.1, Z75388.1, Z75385.1, Z75375.1, Z75372.1, Z75405.1, Z75363.1, AB019439.1, X55344.1, X92222.1, X05715.1, X05714.1, X92268.1, X92267.1, X92266.1, X92265.1, X92263.1, X92262.1, X92261.1, X92260.1, X92259.1, X92257.1, X92234.1, X92233.1, X92229.1, X92223.1, X52895.1, X65911.1, X95660.1, Z14196.1, Z14194.1, Z14193.1, M83133.1, M99607.1, M99601.1, M67500.1, L03677.1, M99683.1, M97921.1, U00922.1, U00923.1, AL049561.16, L43560.1, AA192597.1, AW106443.1, AW106106.1, AA196576.1, AA196377.1, AA195988.1, AA176846.1, AW663328.1, AW403437.1, AI904059.1, AA715258.1, AA152774.1, AW869888.1, AW403989.1, AW403538.1, AC026615.2, AF235100.1, AF192304.1, AC016730.4, AC0191644, AC015501.3, AC068140.1, AC023059.7, AC021286.3, AC025105.1, AC012507.3, AC013555.2, AL355813.3, AC069007.1, AC010601.3, AC010288.4, AC013293.4, AC021017.3, AC007674.2, AC027004.2, AC012500.2, AC022836.2, AC012407.2, AL354674.2, AL355833.1, AL162387.3, AL157770.2, AL121768.1, APOOl 190.1

SEQ ID NO: 540

ZH182/T7

NM_002465.1, X73114.1, X66276.1, AC010205.5, X90475.1, AL133244.1, AC002485.1, AF077338.1, AF078781.1,

AL121586.28, D49525.1, NM_016749.1, AF132970.1, NM H5963.1, AC003999.1, AF002418.1, AF092341.1, AL355094.2, AL163231.2, AL161751.2, AL133371.2, AC000119.1, AL109954.12, Z69722.1, AL034425.6, Z97198.1, Z93242.1, U68267.1, AP001686.1, D63999.1, AK001216.1, AP000949.2, AI871474.1, AW453075.1, AI339458.1, AI865749.1, F31649.1, F27320.1, N66106.1, H15163.1, AA196378.1, AA046973.1, F00500.1, AA176824.1, F26981.1, F32864.1, F02786.1, F36775.1, AA257061.1, F10536.1, AA211479.1, AWl 1209.1, AA923787.1, AA452252.1, AA425104.1, AA194492.1, AA086270.1, AI039263.1, AA194576.1, AA196577.1, AA192152.1, F19051.2, F27495.1, F26423.1, F24238.1, AA640428.1, AA640400.1, F22818.1, F22292.1, AA214001.1, AA196860.1, AA196333.1, AA196001.1, F29262.1, F28900.1, F24330.1, F20624.1, F20593.1, AA193272.1, F32574.1, F31988.1, F28187.1, F22193.1, F19362.2, F25180.1, AA196116.1, F20802.1, F19022.2, F28853.1, AA779499.1, F01063.1, AA176573.1, F23432.1, F20622.1, F29389.1, F20591.1, F01001.1, F34732.1, AA180180.1, F27121.1, AW535343.1, AA410420.1, AA196071.1, F23360.1, F16754.2, F28536.1, F30693.1, F34053.1, F33541.1, F32489.1, F25734.1, AW107813.1, F30557.1, F26321.1, AW108242.1, AA410419.1, F30201.1, F29588.1, F32904.1, AA194692.1, AA194700.1, F26643.1, F20923.1, F32306.1, F32500.1, F32030.1, F26922.1, AI391161.1, AA085911.1, F29539.1, AI171098.1, F24645.1, AC068865.1, AC022662.4, AC019180.4, AC009591.3, AC016468.2, AC055787.1, AC027141.1, AC016017.6, AC006741.2, AL139226.14, APOOl 127.1, AC048343.3, AC025419.6, AC015560.2, AC060779.2, AC009568.4, AC068748.1, AC032025.2, ACOl 1467.5, AC027132.2, AC027131.2, AC024563.2, AC017023.3, AC019155.3, AC060813.1, AC037442.1, AC023535.2, AC025745.1, AC022996.2, AC021617.4, AC012657.3, AC023168.6, AC016335.2, AC017017.3, AC015748.4, AC013276.2, AL355922.1, AL354675.2, AL353634.2, AL157715.2, AL138878.3, AL139429.4, APOOl 102.2, AP000811.1

SEQ ID NO: 541 ZH189/T3

AF039019.1, AJ236885.1, L04282.1, NM_011749.1, X98096.1, U80078.1, U30381.1, AJ001165.1, AC007193.1, AL009179.1, ACOl 1462.4, ACOl 1465.4, AC004846.2, AC005482.2, AC007748.2, AC007860.6, AC006160.9, AC004821.2, AC007191.1, AC002996.1, AC004199.1, U78027.1, AL132986.2, AB040889.1, APOO 1631.1, AC005777.1, AC004013.1, U95740.1, AC007358.2, AC005084.1, AC005089.2, AC003982.1, AP000190.1, AP000046.1, APOOOl 14.1, AP000013.2, AC016830.5, AC016027.15, AC004128.1, AC005534.2, AC004972.2, AC005954.1, AC005790.1, AF069291.1, AC004475.1, AL049795.20, AL050318.12, AL022721.1, AC006028.3, AC006064.9, AC004835.2, AC005821.1, U60902.1, AC005581.1, AL163256.2, AL035681.13, AL035667.12, AP001711.1, AC007731.14, AC008635.6, AC005500.2, AC006038.2, AC006111.2, AC005015.2, AC005023.1, AC005072.2, AC007536.9, AC010077.1, AC005520.2, AC007055.3, AC005037.2, AC005844.7, AC005755.1, AC003104.1, AC004560.1, AC004496.1, AL133415.12, AL133387.8, AL121653.2, AD000864.1, AC000118.1, Z99716.4, Z70288.1, ALl 18497.9, AL031186.8, Z80896.2, AL008635.1, Z83845.14, AL031003.1, Z97054.1, Z84814.1, AL034394.2, AL022143.1, AP001629.1, AP000212.1, AP000134.1, AP000359.1, Z82097.1, AP001434.1, AP000020.2, AL038916.1, AW261045.1, AI158501.1, AA967471.1, AW498473.1, AW376969.1, AW243787.1, AI869078.1, AI826253.1, AL036595.1, AL035988.1 , AI791354.1 , AI732958.1 , AI678392.1 , AI610840.1 , AI379192.1 , AI371165.1 , AI287867.1 , AA928108.1 , AA862344.1, AA703833.1, AA631359.1, AA630961.1, AA629961.1, AA621838.1, AA617939.1, AA587667.1,

AA579765.1, AA553330.1, AA543002.1, AA525157.1, AA521277.1, AA486656.1, AA486559.1, AA226153.1, C05714.1, H93628.1, R37792.1, AW867156.1, AW833911.1, AW817978.1, A W815409.1, AW572202.1, AI540153.1, AI524366.1, AI375542.1, AA659083.1, AA626591.1, AA618206.1, AA532611.1, AA350859.1, AA338904.1, AA320139.1, AA299671.1, AA215929.1, AA152463.1, AA078441.1, N22850.1, H74314.1, F11060.1, F10330.1, AA593516.1, AI039081.1, C14035.1, R74491.1, R22946.1, AA804828.1, AA247422.1, AL043144.2, AI554910.1, AA953588.1, AL134531.1, AA732398.1, AL079476.1, AI351839.1, AA864294.1, AA678569.1, AA603835.1, AA457651.1, AA457650.1, N88725.1, AW405759.1, AA622889.1, AA603315.1, AA443390.1, D29262.1, AW069445.1, AA576736.1, AA478448.1, AA127385.1, AW265080.1, AI078411.1, AW511210.1, AW087679.1, AA939334.1, AA348891.1, AA348890.1, AA287856.1, AA825928.1, R93341.1, AC019289.3, AC032043.1, AC026618.1, AC008481.6, AC020561.2, AC069164.2, AC0261 10.5, AC048356.2, AC008387.4, AC008538.4, AC040930.2, ACOl 1484.2, ACOl 1466.4, AC062024.1, AC026077.3, AC022608.2, AC022879.3, AC010732.3, AC010746.3, AC006988.2, AC012021.1, AL031727.31, AL355339.1, AL157386.3, AL353609.2, AL355097.1, AL159177.3, AP000869.1, AP000714.1, AC063942.2, AC036224.2, AC027307.3, AC008397.6, ACOl 1511.4, AC009121.5, AC008623.3, AC019360.3, AC021814.2, AC027252.1, AC025388.2, AC021024.2, ACOl 1 137.2, AC015619.1, AC015633.1, AL355593.3,

AL139180.5, AL136233.3, AL354940.3, AL355336.1, Z97199.3, Z97197.3, AL132710.13, AC000383.1, AP001012.2, AC024100.8, AC023238.4, AC008532.4, AC068322.1 , ACOl 1 145.3, AC006158.3, AC006156.2, AC040958.1, AC013564.3, AC018845.3, AC023849.1, AC013577.2, AC007597.2, AC002093.1, AL109844.3, AL157383.2, AL158075.3, AL160313.2, AP001988.1 , AC010827.4, ACOl 1957.2, AC024960.2, AC015612.1, AC024098.7, AC034303.2, AC068914.1, AC008405.3, AC008467.4, AC036239.3, ACOl 1232.4, AC021301.1, AL355174.3, AL158034.2, AL162742.4, AL163537.4, AL138685.4, AL354885.1, AL162453.4, AL136173.23, AL023881.23, AL160176.2, AL122005.2, AP002024.1, AP000478.2, AP000483.3

SEQ ID NO: 542 ZH013/T3

X67877.1, AJ276504.1, AF147264.1, AF086817.1, AL161506.2, AE003593.1, AC007277.2, AE000787.1, U80026.1, U21689.1, AL352976.2, AJ010793.1, M24485.1, X08058.1, AC007790.1, AF135398.1, AC007386.3, AC002331.1, AC007980.1, AF083036.1, AC006193.3, AFl 10771.1, S71364.1, U12472.1, M37105.1, M60279.1, AW732607.1, AW812332.1, AI9291 1 1.1, AW242680.1, AA602867.1, AI906380.1 , AW607076.1, AW606846.1, T73537.1, T73517.1, AW210297.1, AA655773.1, AA068592.1, D77836.1, AA830999.1, AF064940.1, AA138445.1, AA138435.1, AW168245.1, AV076039.1 , AV322722.1, AW143010.1, AJ395456.1, AW760490.1, AW623164.1, AW299088.1, AW270326.1, AW265219.1, AW160202.1, AI947047.1, AI899991.1, AI895054.1, AI81 1422.1, AI322055.1, AI132845.1 , AI124151.1, AA934299.1, AA934249.1, AA917214.1, AA917118.1 , AA736358.1, AA720435.1, AA680599.1, AA680598.1, AA652507.1, AA635231.1 , AA629456.1, AA625037.1, AA618841.1, AA61 1013.1, AA610986.1, AA210815.1, R84210.1, T02613.1, AC023196.2, AC017103.3, AC068652.1 , AC034206.1, AC013489.3, ACOl 1654.4, AC021987.2, AC010051.4, AC013201.1, AL158800.1, APOOl 184.1, AP000668.1, AC068796.3, AC018992.3, AC066689.2, AC024738.2, AC016575.6, AC008756.4, AC018694.3, AC008073.2, ACOl 1118.4, AC022267.2, AC016885.3, AC016094.4, AC013449.5, ACOl 1009.4, AC018651.4, AC016128.3, AC016402.1, AL355878.3, AL096828.24, AL109911.22, AL137851.3, AL354725.1, AL158838.3, AP000754.1, AP001005.1, AP000845.1

SEQ ID NO: 543

ZH013/T7

AC004263.1, AL049832.2, AC005940.3, AL049569.13, AL022165.1, AC004814.2, AC002126.1, AC004841.2,

AL163255.2, AL034429.1, AP001710.1, AL049643.12, AF168787.1, D89013.1, AC004655.1, AC004223.1, AC007376.8, ALl lOl 14.1, Z86090.10, AL022237.1, AL135978.2, AL021579.1, AL031984.13, AC005409.1, AC005746.1 , AC003070.1, AL031311.1, AC008101.15, AF053356.1 , AC004000.1 , AC005189.1 , AC006430.22, ACOO 1228.1 , AL049692.13, ACOl 1462.4, AC005480.3, AL163256.2, AP001711.1, AC008635.6, AC004883.2, AC005102.1, AC005667.1, AC005206.1, AL121751.12, AC005602.1, AL049694.9, AC005081.2, AC005696.1, AC004167.1, AF045555.1, U93305.1, AL109657.8, Z99716.4, AL031597.7, AC008009.4, AC007954.7, ACOl 1331.1, AC005080.2, AC003071.1, AC004876.2, AC006449.19, AC005695.1 , AC004752.1 , AL121601.13, AC008072.3, AC005670.1, AC005067.2, AC005529.7,

AC006059.3, Z98941.1, AJ003147.1, AC006111.2, AC006023.2, AC006930.1, AC006211.1, AC004148.1, AP000704.1, AC004382.1, AC002996.1 , AC006277.1, AL023575.1, AL031431.8, Z98036.1, AC016830.5, AC016027.15, AC004492.1, AC005391.1, AC007957.35, AC005332.1, AL031284.9, AF225899.1, AL035462.18, AL008734.10, AC005004.3, AC005793.1, AL121586.28, AC003690.1, AC007919.18, AC003106.1, AC006132.1, AW194386.1, AI079823.1, AI523316.1 , N44678.1 , AA436222.1 , AI435924.1 , AW772322.1 , N35306.1 , AI697742.1 , AI693172.1 , AI690121.1,

AA731394.1, AA678737.1, AI766928.1, F35097.1, AI627917.1, AW512196.1 , AA833896.1, AA833875.1, AA644090.1 , AA425924.1, AI818362.1, AA456924.1, AW022934.1 , AI984168.1, AA158549.1, AA932787.1, AA491767.1, H29914.1, AA669054.1, AA641122.1 , AA084609.1, AW236288.1, AI791659.1, AH92440.1, AA904211.1, F30158.1 , AI623764.1, AI367551.1, AI915081.1, AH33083.1, AA078337.1, AW304580.1, AI653776.1, AI431513.1, AA587516.1, AA523695.1, AA582746.1, AI687343.1, AI962030.1, AA654781.1, AA452887.1, AW190484.1, AI272649.1 , AW512528.1,

AW338081.1, AI978718.1 , AI610737.1, AI565126.1, AI371208.1, AA503298.1, AA492105.1, AA405726.1 , AA299589.1, AI187148.1, AA659333.1, AA652834.1, AA251356.1, AI865196.1, AA668147.1, AA290878.1, AW151870.1, AI141130.1, AI745335.1 , AL041894.1, AA368155.1, AW303872.1 , AW068853.1, AI961983.1, AI871691.1, AL041815.1, AI687972.1, AI417469.1, Al 192839.1 , AI049986.1, AA609834.1, AI654738.1 , AI523813.1, N69462.1, AW836352.1 , R97713.1, AW816516.1, AI758858.1, H56035.1, AI748842.1, AI859438.1, AA613624.1, AA827383.1, AA309129.1, AA658853.1, AC023196.2, AC016824.4, AL355001.3, ACOl 1378.3, AC069198.1, AC007318.3, AC008053.2, AP001385.1, APOOl 157.1, AC008745.4, AL109947.5, AL136222.3, APOOl 192.1, AL139401.3, AC0679I0.I, AC019073.3, AC036183.2, AC015982.3, AP001444.1, AC019171.3, ACOl 1212.3, ACOl 1470.4, AC018693.2, AL136332.1 , AC008622.4, AC011247.3, AC010466.1 , AC006452.3, AC016701.2, AC016666.2, AL137802.6, AL355149.2, AC025275.2, AC009152.5, AL033520.15, AL138791.2, AC022243.2, AL137126.4, AL160005.2, AC007637.7, AC021988.3, AC023973.2, AL121712.22, AP000575.2, AP000944.2, AC010531.3, AC023121.3, AC040160.2, AC032035.2, AC016331.2, AC004840.2, AC026513.2, AC026685.1, AL139385.3, AC026164.3, AC024969.2, AC007924.2, ACOl 1638.3, AC005848.1, AC004586.1, AC008569.5, AC026191.1, AC023470.2, AC025339.1, AC015795.3, AL354986.1, AL160010.3, APOOl 177.1, AC010515.5, AC016168.3, AC026361.3, AC023097.2, AC026130.2, ACOl 1401.5, AC012321.4, AC026856.2, AL136115.6, AL161726.3, AL158830.5, ALl 32801.1, AC012310.4, AC007612.2, ACOl 1729.4, AL139022.1, AC008378.5, AC016289.3, ACOl 1326.9, AC008894.4, AC021194.2, AL355076.1, AC034243.2, AC016611.5, AC018695.3, AC026836.2, AC018391.4, AC008482.4, AC016542.4, AL138817.5, AC026771.2, AC012651.4

SEQ ID NO:544

GROUP ZH051 5' seq,

AW194386.1, AI079823.1, AI523316.1. N44678.1, AA436222.1, AI435924.1, AW772322.1, N35306.1, AI697742.1,

AI693172.1, AI690121.1, AA731394.1, AA678737.1, AI766928.1, F35097.1, AI627917.1, AW512196.1, AA833896.1, AA833875.1, AA644090.1, AA425924.1, AI818362.1, AA456924.1, AW022934.1, AI984168.1, AA158549.1,

AA932787.1, AA491767.1, H29914.1, AA669054.1, AA641122.1, AA084609.1, AW236288.1, AI791659.1, AI192440.1, AA9042U.1, F30158.1, AI623764.1, AI367551.1, AI91508I.1, AI133083.1, AA078337.1, AW3O4580.1, AI653776.1, AI431513.1, AA587516.1, AA523695.1, AA582746.1, AI687343.1, AI962030.1, AA654781.1, AA452887.1, AW190484.1, AI272649.1, AW512528.1, AW338081.1, AI978718.1, AI610737.1, AI565126.1, AI371208.1, AA503298.1, AA492105.1, AA405726.1, AA299589.1, AI187148.1, AA659333.1, AA652834.1, AA251356.1, AI865196.1, AA668147.1, AA290878.1, AW151870.1, AI141130.1, AI745335.1, AL041894.1, AA368155.1, AW303872.1, AW068853.1, AI961983.1, AI871691.1, AL041815.1, AI687972.1, AI417469.1, AI192839.1, AI049986.1, AA609834.1, AI654738.1, AI523813.1, N69462.1, AW836352.1, R97713.1, AW816516.1, AI758858.1, H56035.1, AI748842.1, AI859438.1, AA613624.1, AA827383.1, AA309129.1, AA658853.1, AI951118.1, AI880940.I, AI816672.1, AI816636.1, AI816629.1, AI816628.1, AI816623.1, AI816622.1, AI816621.1, AI816619.1, AI816617.1, AI816615.1. AI816614.1, AI816613.1, AI816612.1, AI816611.1, AI816609.1, AI816608.1, AI816605.1, AI816601.1, AI815377.1, AI815338.1, AI815337.1, AI815336.1, AF041408.1, AA249712.1, AA247964.1 , AA247827.1 , AA096046.1, AA095435.1, N89520.1, N88782.1, N83229.1, N83168.1, N88601.1, N88018.1, N84855.1, N84781.1, N84048.1, N83992.1, N83991.1, H58760.1, AI816627.1, AA095359.1, AA093577.1, AA096066.1, AA095641.1, AA092086.1, AW587463.1, AI816673.1, AI816670.1, AI816665.1, AI816635.1, AI816630.1, AI816625.1, AI816620.1, AI816618.1, AI816616.1, AI816606.1, AI816603.1, AI815354.1, AI815350.1, AI815348.1, AI815340.1, AW587505.1, AI880936.1, AI816624.1, AI815352.1, AI815334.1, AA096061.1, N86694.1 , N84718.1 , N55698.1 , AI816680.1 , AI816677.1 , AI816676.1 , AI816634.1 , AI815356.1 , AI815353.1 , AJ241143.1, AA471338.1, N84830.1, N84712.1, N83993.1, AI816682.1, AI816671.1, AI816666.1, AI816604.1, AA249353.1, AA093224.1, N89307.1, N87898.1, N84740.1, N55721.1, AI815335.1, AA095511.1, N88518.1, N87989.1, AI816610.1, AI816674.1 , AC067744.2, AL162272.3, AC007351.16, AC010884.4, AC015871.1, AC019337.1, AC015860.2, AL137076.5, AC009401.2, AC027141.1, AC024370.2, AC015720.2, AC015850.1, AC014239.1, AC009553.1, AC036209.2, AC060754.3, AC061987.1, AC027699.1, AC021187.4, AC013707.2, AC015888.3, AC010987.4, AC015924.1, AC012248.2, AC013152.1, AL356457.1, AL022284.1 SEQ ID NO: 545

GROUP ZH051 3'SEQ

AL050302.2, AL163203.2, AL049911.2, NM H4915.1, AB028997.1 , Z22786.1 , ABOl 1137.2, AL163202.2, AL009051.1, AP001464.1, AP000542.1, AC006475.3, ALl 38654.1, AP000365.1, AP000548.1, AF035938.1, AL132985.2, AP001302.1, AC004936.2, AC006157.2, ALl 10120.11, AL078614.2, AC004142.1, AC005284.1, AL079349.2, AL096867.15, AL035690.10, AP001821.1, AW373574.1, AW170035.1, AW614036.1, AL046701.1, AA759177.1, AW297165.1,

AA521089.1, M78662.1, AA296607.1, AI920892.1, AI122649.1, AW438556.1, AI236531.1, AI180434.1, AI180260.1, AH76501.1, AA892166.1, AI058351.1, AI044283.1, AA533501.1, AW656081.1, AW656019.1, AW457201.1, AW247016.1, AI984814.1, AI957948.1, AI904680.1, AL046634.1, AL036452.1, AI786726.1, AI770175.1, AI690374.1, AI527257.1, AI450726.1, AI446107.1, C87958.1, AA773607.1, AA556007.1, AA398033.1, AA289552.1, AA260439.1, AA170331.1, AA056391.1, W44909.1, W26464.1, R62950.1, M61978.1, AW574796.1, AW418527.1, AJ281607.1, AW338178.1, AW331138.1, AW171900.1, AW088936.1 , AW052899.1 , AI972424.1, AI920706.1, AV131385.1, AI538762.1 , AI200709.1 , Al 192436.1 , Al 154223.1 , AI093327.1 , AA970354.1 , AA631332.1 , AA291987.1 , N74455.1 , N20326.1, H97559.1, AW373574.1, AW170035.1, AW614036.1, AL046701.1, AA759177.1, AW297165.1, AA521089.1, M78662.1, AA296607.1, AI951295.1, AI920892.1, AI122649.1, AW438556.1, AI236531.1, All 80434.1, AH 80260.1, AI176501.1, AA892166.1, AI058351.1, AI044283.1, AA533501.1, AW656081.1, AW656019.1, AW457201.1,

AW247016.1, AI984814.1, AI957948.1, AI904680.1, AL046634.1, AL036452.1, AI786726.1, AI770175.1, AI690374.1, AI527257.1, AI450726.1, AI446107.1, C87958.1, AA773607.1, AA556007.1, AA398033.1, AA289552.1, AA260439.1, AA170331.1, AA056391.1, W44909.1, W26464.1, R62950.1, M61978.1, AW662136.1, AJ281607.1, AW320227.1, AW087179.1, AI950371.1, AI684965.1, AI368143.1, AI311542.1, AI302518.1, AI192436.1, AH 48480.1, AI069596.1, AI057937.1, AA910838.1, AA856548.1, AA768420.1, AA264497.1, AA708873.1, AA483705.1, AA150449.1, AA149652.1, AA101607.1, AA071350.1

SEQ ID NO: 546 ZH012/T3 AL157387.1, AL162272.3, AC015940.2, AC008088.2, AC026271.2, AC022596.3, AC036170.2, AC015650.1, AC023067.3, AL133290.3, AL161912.3, AC021150.5, AC024252.3, AC019078.3, AC017099.3, AL139008.8, AL355472.2, AL161418.4, AL353626.1, AL158083.1, AL137219.1, AL049185.4, AC024107.9, AC068690.1, AC010248.4, AC027713.2, AC009297.3, AC021009.3, AC010959.3, AC024170.1, AC018844.1, AL157695.2, AL138965.3, AI951118.1, AW000914.1, AI922499.1, AI871874.1, AA991162.1, AA828186.1, AA661357.1, C60377.1, AA471702.1, AA095151.1, AW659699.1, AW519678.1, AV282871.1, AW029403.1, AI902224.1, AV045752.2, AI31 1562.1 , AU023568.1, AU023063.1, AI075925.1, AA701829.1, AA599836.1, , AC067744.2, AL162272.3, AC007351.16, AC009401.2, AC027141.1 , AC021762.3, AC024370.2, AC014239.1, AC046187.2, AC036209.2, AC027696.2, AC060754.3, AC061987.1, AC050524.1, AC034685.1, AC026218.2, AC031752.1, AC027699.1, AC009833.3, AC021 187.4, AC017001.4, AC013707.2, AC010705.14, AC021024.2, AC0I 2248.2, AC013152.1, AL080314.29, AP001455.1, AL022284.1 , ACO 16934.4, AC027748.2, AC036208.2, AC067909.2, AC068541.2, AC026428.2, AC012631.3, AC008885.3, AC022395.2, AC060232.3, AC013361.4, AC024379.2, AC004932.2, AC045500.1 , AC044804.1, AC024466.3, ACOl 1186.3, AC019207.3, AC009407.3, AC016916.4, AC017083.4, AC023115.3, AC025596.1, AC023988.2, AC023567.2, AC023399.2, AC016444.2, AC013763.2, ACOl 1296.1, AC009858.1, AL137863.7, AL356132.3, AL355351.2, AL354884.2, AL161730.3, AL161642.3, AL138683.2

SEQ ID NO: 547

ZH012/T7

U62317.2, AL021939.1, AC005231.2, AC005940.3, AC008039.1, AC007216.2, AF064863.1, AL163283.2, AC007387.3, AC006312.8, AC006064.9, AC005914.1, U80017.1, AL109976.22, AL031283.26, AL163215.2, AP001670.1, AP000359.1, AC005004.3, AC0O5696.1, AC005387.1, AL078638.9, D88270.2, AC008635.6, AC008521.5, AC000353.27, U91321.1, AC005486.2, AC004967.2, AL121809.4, AL163285.2, Z98742.5, ACOl 1449.6, AC008101.15, AC006285.11, AC004858.2, AC007240.2, AC006930.1, AC005725.1, AC005899.1, AC004638.1, AL163259.2, AL163255.2, AL135749.2, AL121603.2, AL121658.2, Z97630.11, AL022165.1, AL033521.2, AP001710.1, AP001714.1, AC007782.20, AC002377.1, AC004000.1 , AC007919.18, AC005280.2, AC005484.2, AC006277.1, AC006130.1 , AC005512.1,

ALl 17186.3, AL049766.14, L78810.1, Z98051.6, AL034400.2, AC008372.6, AC007051.3, AC005971.5, AC004686.1, AL132712.2, AL049843.18, AC008079.23, AC007324.55, AF196969.1, AC006538.1, AC004771.1, AC005619.1, AC005209.1, AL109935.39, AL163270.2, AL035587.5, AL031003.1, Z84469.1, AL031311.1, AP001725.1, AP000474.2, AC008018.20, AC000025.2, AC005011.2, AC004878.2, AC004895.2, AC006544.19, AC005544.1, AC004678.1, AC002553.1, AC002350.1, U73630.1, AL035422.12, AC005358.1, AC006139.1, AW170035.1, AA588001.1, AA357669.1, AA502104.1, AW080062.1, AW008089.1, AI952885.1, AA323778.1, AA577906.1, AA569631.1, AA604333.1, AA601355.1, AL048969.1, N49425.1, AW069670.1 , ALl 20269.1, AA224525.1, AW263415.1, AI354847.1 , AA634954.1, AA228460.1, AW440545.1, AA584482.1 , AW820127.1, AW504011.1, AI679002.1, AA577824.1, AL138265.1, AL041706.1 , AL048626.1, AW600804.1, AI791819.1, AA953588.1, AA679794.1 , AA482227.1 , AA228418.1 , AA228330.1 , AAl 60658.1 , AA806799.1 , AA804999.1 , AA707833.1 , AW504240.1 , AI6311 19.1 ,

AI354862.1 , AA805869.1, AA665449.1, AA613789.1, AA564634.1, AA255626.1, AA209415.1, W64166.1, N80210.1 , H56369.1, AI038990.1, AA613954.1, AA584876.1, AA576736.1, AA507657.1, AW406447.1, AWl 67330.1 , AW088224.1, AL037632.3, AI927170.1, AI580906.1, AA837677.1, AA808796.1, AA714221.1, AA634147.1, AA526787.1, AA516310.1, AA223932.1, AA113159.1, W96277.1 , ALl 35377.1, AI924251.1, AI243789.1, AI124706.1, AA634991.1, AA443390.1, AA017377.1, AW630599.1, AA708108.1, AA573496.1 , AA459749.1, N99489.1, AW248523.1, AWl 88427.1, H70699.1, AW833144.1, AI821596.1, AA643457.1, AA643454.1, AA643452.1, AA348890.1, AA290878.1, AA015649.1, AW167374.1, AL044340.1, AI289277.1, AA287856.1, AC023151.3, AL161652.5, AC010243.3, ACOl 1498.4, AC024720.3, AC025336.2, AL354707.6, AP001458.2, AC008736.4, AL133373.1, AC012583.3, AC010311.7, AC032035.2, AC026472.3, AC020779.3, AC017052.4, AC024100.8, AC012313.5, AC026464.3, AC022159.4, AC009053.4, AC034193.2, AC027281.2, AJ009613.2, AC008378.5, AC009048.5, AC012442.2, AC023038.2, AL354765.1, AL162415.2, AL139255.1 , AC009963.4, AL158207.3, AC008474.6, AC026803.2, AC008749.4, AC027069.2, AC020978.3, AC022965.2, AL158075.3, AP001885.1, AC015551.9, AC026125.2, ACO07430.17, AC005973.4, AC069024.1, AC022318.3, AC046171.2, AC010354.4, AC008610.4, AC010530.3, AC010319.6, AC025690.3, AC016207.4, AC027272.2, AC016916.4, AC021860.3, AF228728.1, AL139249.2, AL355885.1, AL355860.1, AL133477.3, AP001201.4, APOOl 191.1 , AC006534.3, AC040173.2, ACOl 1484.2, AC008758.3, AC020558.3, AC023230.2, AL356385.1, AL158846.2, AL158052.2, AC023047.11, AC053546.3, AC022285.5, AC024460.2, AC026685.1, AC005845.1, AL121897.24, AL160055.3, ACOl 1464.4, AC007902.2, AC024438.2, AL353812.6, AL109743.3, AL354980.1, APOO 1871.1, AC009451.5, AC026936.2, AC022738.3, ACOl 1212.3, AC006286.13, AL158815.4, AL157931.2, AC018998.4, AC008848.6, ACOl 1200.2, AC008481.6, AP000833.1

SEQ ID NO: 548

ZH015/T3

AL163203.2, AL050302.2, AL049911.2, AP000026.1, AP000025.1, NM_014915.1, AKOOl 137.1, AB028997.1,

AC007617.10, AE003447.1, AJ223186.1, AE003494.1, AC004739.1, AC006355.3, AC006045.2, U48386.1, AF044083.1, AL163233.2, AL163224.2, Z70270.1, Z74696.1, U41993.1, D82813.1, AP001679.1, AP001688.1, AP001506.1, AP000961.2, AC005522.2, AF246422.1 , AC007379.2, AC006478.2, AC004996.1, AC007099.3, AC005100.2, AC007100.3, AC005879.3, AF076621.1, AC005331.1, AC005177.1, AC004045.1, AL133465.30, AL132766.13, AL109985.2, AL078644.10, AL022395.2, Z82193.1, Y18930.1, AI951118.1, AW000914.1, AI922499.1, AI871874.1, AA991162.1, AI604114.1 , AI449232.1 , AA661357.1, C60377.1, AA471702.1, AA095151.1 , AW519678.1, AV282871.1, AI902224.1, AV045752.2, AI311562.1, AI075925.1, AA828186.1, AA701829.1, AC067744.2, AL162272.3,

AC007351.16, AC009401.2, AC027141.1, AC024370.2, AC014239.1, AC036209.2, AC060754.3, AC061987.1, AC027699.1, AC021 187.4, AC013707.2, AC012542.4, AC012248.2, AC013152.1, AL356457.1, AP001455.1, AL022284.1, AC046187.2, AC022418.3, AC008885.3, AC027696.2, AC060232.3, AC004932.2, AC044804.1, AC019259.3, AC016916.4, AC023988.2, AC023399.2, AC010988.3, AC016444.2, AC005139.3, AL356132.3, AL161730.3

SEQ ID NO:549 ZH024/T3 AL163203.2, AL050302.2, AL049911.2, AP000026.1, AP000025.1, NM_014915.1, AKOOl 137.1, AB028997.1,

AC007617.10, AE003447.1, AJ223186.1, AC015600.6, AE003617.1, AC004739.1, AC006355.3, AC006045.2, U48386.1, AF044083.1, Z70270.1, AL163224.2, AJ250841.1, Z74696.1 , U41993.1, D82813.1, AP001679.1, AP001506.1, AP000961.2, AC005522.2, AC007379.2, AC005100.2, AC005479.2, Yl 8930.1, Z69637.1, AL022395.2, AI951118.1, AI482625.1, AI487533.1, AW000914.1, AI922499.1, AI902224.1, AI871874.1, AA991162.1, AA736439.1 , AA661357.1, AA660701.1, C60377.1, AA471702.1, AA219203.1 , AA095151.1 , AW208236.2, AW519678.1, AV322534.1,

AV282871.1, AV382738.1 , AI808313.1, AV045752.2, AV043012.2, AI583901.1 , AI478844.1 , AI311562.1 , AI075925.1 , AA828186.1, AA701829.1 , AA660895.1, AA660377.1, AC067744.2, AL162272.4, AC009401.2, AC027141.1, AC024370.2, ACOl 1254.3, AC012582.3, ACO 14239.1 , AL354836.1, AC062032.2, AC062004.2, AC036209.2, AC022139.3, AC027699.1, AC012248.2, AL353892.2, AP000872.2, APOOl 133.1, AC022418.3, AC026295.3, AC024918.2, AC021149.4, AC022811.1, AC010988.3, AC016444.2, AC005139.3

SEQ ID NO: 550

ZH024/T7

AL033504.3, AC006604.1, AE003524.1, AFOl 6675.2, AC007437.16, AF039039.2, AF047655.1, AC006239.5, AF101310.1, AF098500.1, U80023.1, AF068712.1, AC004219.1, Z81567.1, Z78065.1, AF003144.1, AL163241.2,

U50072.1, U40425.1, AP001696.1, AP001597.1, AB015476.1, AC008638.5, AE003639.1, AC002116.1, AC006699.2, AC008102.16, AC005165.1, AC007297.22, AF039904.1, AC007192.1, AF069076.1, AF077542.1 , AF098737.1, AF098736.1 , AF098735.1, AF050665.1, AF099914.1, AC002375.1, AL161548.2, AF014161.1, AF014160.1, AL021710.1, Z92972.1, Z48543.1, AL121782.9, AL032640.1, AL096800.20, AL163273.2, U80029.1, ALl 10500.1, U70852.1, AL096772.5, U50065.1 , Ml 8370.1, Z80332.1, X06759.1, X06386.1, U15763.1, AP001728.1, AB008822.1, AP001432.1, M55506.1, AP000151.1, D83253.1, AP000009.2, D90194.1, D90195.1 , U14163.1, AA601511.1, AA412108.1, AL044891.1, AA393080.1, AI913336.1, AI908240.1, AA489119.1, AI681153.1, AI013642.I , AI145328.1, AA894065.1, AW655882.1, AW654312.1, AW654290.1, AW632141.1 , AW481770.1, AW298986.1, AW239842.1, AI594437.1, AI090825.1 , AA597263.1, AA409087.1, AL157387.2, AL162272.4, AC022596.4, AC015818.5, AL356259.1, AL162715.3, AC026081.2, AC021384.3, AL139327.13, AC034129.2, AC068536.2, AC040905.2, AC027205.2, AC024004.2, AL356360.1, AL354773.4, AP001996.1, AC044813.3, AC048334.5, AC019230.3, ACOl 1740.2, AC027583.1, ACOl 1009.4, AC021442.1 , AC019577.1, AC006903.1, AC006727.1, AC018917.6, AC068778.4, AC010546.3, AC009111.4, AC068376.1, AC064876.1, AC025223.4, AC062034.1, AC026043.3, AC025965.2, ACOl 1714.1, AC009598.2, AC006842.1, AL158089.6, AL137140.5, AL354664.2, ALl 17348.14, AL03101 1.20, AL022597.5, AP001486.1, AP000822.1, AL021450.1, Z95393.1

SEQ ID NO: 551

ZH046/T3

AL163203.2, AL050302.2, AL04991 1.2, AP000026.1, AP000025.1, NM_014915.1, AKOOl 137.1, AB028997.1, AC007617.10, AE003447.1, AJ223186.1, AE003494.1, AC004739.1, AC006355.3, AC006045.2, U48386.1, AF044083.1, Z70270.1, AL163224.2, Z74696.1, U41993.1, D82813.1, AP001679.1, AP001506.1, AP000961.2, AC005522.2, AC007379.2, AC006478.2, AC004996.1, AC007099.3, AC005100.2, AC005879.3, AC005331.1, AC005177.1, AC004045.1, Y18930.1, AL133465.30, AL132766.13, AL109985.2, AL022395.2, Z82193.1 , AI9511 18.1 , AW000914.1, AI922499.1 , AI871874.1 , AA991162.1, AU006171.1, AA661357.1, C60377.1, AA471702.1, AA095151.1, AW519678.1, AV282871.1, AI902224.1, AV045752.2, AI311562.1, AI075925.1 , AA828186.1, AA701829.1, AC067744.2, AL162272.4, AC007351.16, AC009401.2, AC027141.1, AC024370.2, AC014239.1, AC062032.2, AC036209.2, AC060754.3, AC007131.3, AC061987.1, AC027699.1 , AC021187.4, AC013707.2, AC012410.2, AC012542.4, AC012248.2, AC013152.1, AL022284.1, AC062015.2, AC046187.2, AC022418.3, AC008885.3, AC027696.2, AC060232.3, AC004932.2, AC024466.3, AC019259.3, AC016916.4, AC023988.2, AC016444.2, AC005139.3, AL161730.3

SEQ ID NO: 552

ZH046/T7

AL050302.2, AL163203.2, AL04991 1.2, NM_014915.1, AB028997.1, AF090187.1, AL009051.1, ABOl 1137.2,

AL138654.1, AP000365.1, AP000548.1, ACOl 1661.5, APOO 1302.1 , AC004936.2, AC006157.2, Z99291.1, AL031599.1, U40160.1, AC008526.5, AF156143.1, AC009402.3, AC004142.1, AC009513.2, AC006475.3, AC005760.1 , AC005358.1, AL161595.2, Zl 1874.1, X70810.1, AL022605.3, U58744.1, X68658.1, X17051.1, AJ002397.1, AW373574.1, AW170035.1, AA759177.1 , AL046701.1, AI957948.1, C87958.1, AW628933.1, AW469178.1, AW338178.1, AW331138.1, AW320227.1, AW171900.1, AW087179.1, AW052899.1, AW042526.1, AI972424.1, AI950371.1, AI920706.1 , AI784583.1, AU072482.1 , AI684965.1, AI460172.1, AI148480.1, AI093327.1, AI025802.1, AA970354.1, AA708873.1, AA151 U7.1, AA15O449.1, AA149652.1, AA136980.1, AA101607.1, AA071350.1, W73028.1, W35448.1, H97559.1, H96023.1, AL157387.2, AL162272.4, AC022596.4, AC015940.2, AC008088.2, AL354819.2, AL157695.2, AL138965.3, AC023067.3, AC016739.2, AC025384.2, AL161912.3, ACOl 1983.3, AL137219.1, AL049185.4, AC040973.2, AC068690.1, AC026427.2, AC020901.5, AC010248.4, AC016684.1, AC026271.3, AC025076.3, AC051644.2, AC008390.6, ACOl 1434.2, AC026081.2, AC008426.2, AC026395.2, AC016215.4, AC019042.3, AC009499.2, AC021755.4, AC012174.2, AL356312.1, AL138749.7, AP001541.1

SEQ ID NO: 553 ZH015/T3 AL163203.2, AL050302.2, AL049911.2, AP000026.1, AP000025.1, NM_014915.1, AKOOl 137.1, AB028997.1, AC007617.10, AE003447.1, AC007639.5, AJ223186.1, AC010340.7, AE003494.1, AC004739.1, AC004886.1, AC006355.3, AC006045.2, U48386.1, AF044083.1, Z70270.1, AL163233.2, AL163224.2, Z74696.1, U41993.1 , D82813.1, AP001679.1 , AP001688.1, AP001506.1, AP000961.2, AC005522.2, AC007379.2, AC006478.2, AC004996.1, AC007099.3, AC005100.2, AC005879.3, AFl 16775.1, AC005331.1, AC005177.1, AC004045.1, AL021879.3, Y18930.1, AL133465.30, AL132766.13, AL109985.2, AL078644.10, AL022395.2, Z82193.1, AI951118.1 , AW000914.1, AI922499.1, AI871874.1, AA991 162.1, AA661357.1, C60377.1, AA471702.1, AA095151.1 , AW519678.1, AV282871.1, AW133941.1, AW010698.1, AI902224.1, AV045752.2, AI311562.1, AI075925.1, AA828186.1, AA701829.1, AC067744.2, AL162272.4, AC007351.16, AC009105.6, AC009054.4, AC009401.2, AC027141.1, AC024370.2, AC014239.1 , AC027783.2, AC062032.2, AC036209.2, AC060754.3, AC007131.3, AC061987.1, AC027699.1, AC021187.4, AC023567.2, AC013707.2, AC012410.2, AC012542.4, AC012248.2, AC013152.1, AL022284.1, AC062015.2, AC022418.3, AC008885.3, AC027696.2, AC060232.3, AC004932.2, AC019259.3, AC016916.4, AC023988.2, AC023399.2, AC016444.2, AC005139.3, AL161730.3

SEQ ID NO: 554 ZH015/T7

AL050302.2, AL163203.2, AL049911.2, NM_014915.1, AB028997.1, ABOl 1 137.2, AL009051.1, AL138654.1, AP000365.1, AP000548.1, ACOl 1661.5, AP001302.1, AE003737.1, AC021199.5, AC006157.2, AF090187.1, AC006557.2, AL021571.1, Z99291.1, AC008526.5, AC009402.3, AC004142.1, AC009513.2, AC006475.3, AC005760.1, Zl 1874.1, AL121965.19, X70810.1, AL022605.3, U58744.1, X17051.1, AW373574.1, AW170035.1, AL046701.1, AA759177.1, AV302770.1, AI957948.1, C87958.1, AW693195.1, AW469178.1, AW335526.1, AW334038.1,

AW333464.1 , AW333047.1, AW332908.1, AW332488.1, AW331138.1, AW320227.1, AW171900.1, AW087179.1, AW052899.1, AW042526.1 , AI972424.1, AI950371.1, AI920706.1, AI784583.1, AU072482.1, AI684965.1, AI593873.1, AI460172.I , AI148480.1, AI093327.1, AI025802.1, AA970354.1 , AA708873.1, AA657017.1, AA230060.1, AA151117.1, AA150449.1, AA149652.1, AA136980.1, AA101607.1, AA071350.1, W73028.1 , H97559.1, H96023.1, AL157387.2, AL162272.4, AC022596.4, AC015940.2, AC008088.2, AL354819.2, AL157695.2, AL138965.3, AC026271.3, AC023067.3, AC025384.2, ACOl 1983.3, AL137219.1, AL049185.4, AC026427.2, AC010248.4, AC016684.1, AC025076.3, AC022507.12, AC008390.6, AC026081.2, AC013362.4, AC025355.2, AC016215.4, AC019042.3, AC021755.4, AC020749.2, AC023366.2, AC012174.2, AC019249.3, AC007645.3, AL354933.2, AL356312.1, AL161912.3. AL162251.3

SEQ ID NO: 555

ZH082/T3

AL050302.2, AL163203.2, AL049911.2, NM_014915.1, AB028997.1, ABOl 1 137.2, AL009051.1, AL138654.1,

AP000365.1, AP000548.1, AF132960.1, NM_015954.1, AC022073.13, AE003737.1, AC004936.2, AC006157.2, Z99291.1, U40160.1, AC008526.5, AC008912.4, AC009513.2, AE001733.1 , AC006475.3, AC005760.1 , AC005358.1,

AC004646.1, AL161595.2, AL022605.3, U58744.1, AW373574.1, AW170035.1, AA759177.1, AL046701.1, AA663940.1, AW591494.1, AW298804.1, AW236267.1, AW044611.1, AW027676.1, AI970722.1, AI957948.1 , AI829478.1, AI804380.1, AI741971.1, AI719929.1, AI707567.1, AI699017.1, AI611772.1, AI474518.1, AI422776.1 , AI417636.1, AI383290.1 , AI375177.1 , AI370228.1 , AI364071.1, AI362738.1 , AI355919.1 , AI355185.1 , AI339716.1 , AI281540.1 , AI280241.1, AI274583.1, AI167768.1, AI096951.1 , AI085092.1, AA974155.1, AA887695.1, AA866156.1, AA854736.1, C87958.1, AA831564.1, AA723565.1, AA714063.1, AA649041.1, AA642218.1, AA576795.1, AA525504.1, AA468847.1, AA449351.1, AA243685.1, AA173664.1, AA171684.1, C00125.1, N74602.1, R94195.1 , R89587.1, AW469178.1, AW338178.1, AW331 138.1, AW320227.1, AW171900.1, AW087179.1, AW052899.1, AW042526.1, AI972424.1, AI950371.1, AI928717.1, AI920706.1, AI784583.1, AU072482.1, AI684965.1, AI460172.1, AI148480.1, AI093327.1, AI025802.1 , AA970354.1, AA947120.1 , AA708873.1, AA504469.1, AA151117.1, AA150449.1 , AA149652.1,

AA136980.1, AA101607.1, AA071350.1, W73028.1, H97559.1, H96023.1, AL157387.2, AL162272.4, AC022596.4, AC015940.2, AC008088.2, AL354819.2, AL157695.2, AL138965.3, AC021219.2, AL353575.3, AL353136.3, AC023067.3, AC025384.2, AL161912.3, AC026271.3, AL137219.1, AC068690.1, AC026427.2, AC020901.5, AC027253.1, AC022080.5, AC019255.2, AC017801.1, AC016684.1, AC022124.3, AC012604.3, AC027625.2, AC034168.2, AC016215.4, AC021755.4, AC009586.3, ACOl 1286.4, AC009881.3, AL135903.2, AP001284.1

SEQ ID NO: 556 ZH082/T7

AC004527.2, AL163204.2, AP001466.1, AL078614.2, AL355072.2, AL023877.1 , AC007501.2, AC003682.1, AC006032.2, AC004650.1, Z93384.1, Z72505.1, AL161580.2, AL021811.1, AC001228.1, U51281.1, AC024844.1, AF007544.1, AC004659.1 , Z68217.1, AL163237.2, U41019.1, AP001692.1, AE003837.1, AC004605.1, Z78416.1, ALI 32943.2, AL132777.2, T95599.1 , AU070040.1, AA140870.1, T62163.1, AA648760.1, AW674307.1, AW664490.1, AW334871.1, AW332410.1, AW331901.1, AV383655.1, AI829650.1 , AI743111.1, AI697058.1, AI570895.1, AI570177.1 , AI498194.1 , AI453419.1, AI368890.1, AI264827.1, AI220282.1, AI219432.1, AA878714.1, AA777557.1, AA772182.1, AA765215.1, AA745684.1, AA722275.1 , AA720970.1, AA662367.1, AA593706.1, AA526463.1, AA525457.1, AA525257.1 , AA447296.1, AA424313.1, AA404343.1, AA227150.1, AA149254.1, W61377.1 , W23934.1, N94485.1, AW829301.1, AW646575.1, AW640539.1 , AW516477.1 , AW309883.1 , AW139182.1 , AI309747.1, AI301308.1, AI264756.1, AI088990.1, AI018656.1, AA830992.1, AA740946.1, AA703326.1 , AA387253.1 , AA074666.1, AL157387.2, AC027800.2, AP001004.2, AC022028.2, AC023528.3, AC024170.1, AL137244.14, AC010738.3, AC009406.3, AC015808.3, AC015945.3, AP001025.2, AC064867.1, ACOl 1962.2, AC010832.3, AC022572.3, AC022551.3, AL157368.2, AC024583.3, AC067949.1, AC021029.3, AC007222.1, AL356137.2, AL163540.3, AL162395.2, AL137218.1, AL162272.4, AL138812.2, AL353620.1 , AC02I078.2, AC008818.4, ACOl 1274.3, AC021738.2, AC009569.2, Z93245.1 , ACOl 1302.2, AC016720.4, AL139278.2, AC036237.4, AC009583.3, AC022952.3, AC006281.6, AC016466.3, AC021668.1, AL139008.8, AL137066.5, AL161629.2, Z95311.10, AC018922.8, AC018920.5, AC039057.3, AC020672.3, AC007670.2, ACOl 3772.3, AC021801.1

SEQ ID NO: 557 ZH1336/T3 AL163203.2, AL050302.2, AL049911.2, AC004802.1, AC002412.1 , D88270.2, AC005856.1 , U63630.1, AL035659.22, AL008635.1, AC016678.4, AC004019.20, AC024076.4, AC012078.3, AC009415.2, AC010072.5, AC005775.1, AC002400.1 , AC0OO355.1, AFl 11170.3, AF225900.1, AF225899.1, AC005250.1, AC004008.1, AF176815.1, AC006014.2, AC006019.2, AC007274.2, AC007877.3, AC006368.2, AC007387.3, AC009516.19, AC002307.1, AC007214.13, AC007919.18, AC004814.2, AC007237.3, AC005089.2, AC007308.13, AC005488.2, AF134726.1, AC0O6241.1, AC006274.1, AC006130.1, AC004047.1, AC005722.1, L78833.1, AC004055.1, AC005523.1, AC005493.1, AC003682.1, AC004754.1, AC004449.1, AC004030.1, AC002558.1, AC002037.1, AL049759.10, AL035079.14, AL022163.1, AL021393.1, AL009051.1 , AL023494.12, AL031602.14, AL163226.2, AL163222.2, AL160237.2, AL135940.i l, AL137918.2, AL133238.2, AL035072.16, AL121601.13, AL034547.11, Z97630.11, Z68162.1, Z83001.1, Z99128.1, AL035604.15, Z84718.2, AL031657.2, AL009029.1, Z86061.1, AL033525.10, Z69706.1, Z69918.1, D87675.1 , D00591.1, AP001681.1 , AP001677.1, AP000365.1, AP000502.1, AP000957.2, AP000964.2, AP000307.1, AP000351.3, AP000548.1, AP000088.1, AC006581.16, AC005369.1, AL035695.17, AC006157.2, AW170035.1 , AI375710.1, AA100715.1, N765O4.1, AW812789.1 , AW577142.1, AW026629.1, AI291588.1, AA601355.1, N98802.1, N78038.1, R92359.1, AW840742.1, AW627425.1, AW517377.1, AW503014.1, AW500125.1, AW298643.1, AW193265.1, AW103981.1 , AW050726.1, AI990487.1, AI978583.1, AI950451.1, AI937125.1 , AI907878.1, AL036070.1, AI801591.1, AI754658.1, AI687343.1, AI31 1927.1, AI133164.1, AA992337.1, AA834843.1, AA458863.1 , AA362698.1, AA338904.1, AA314877.1, AI580781.1, AI168185.1 , AI129968.1, AA788990.1, AA503577.1, AI823736.1, AI126468.1, AA621278.1, AA514328.1, W56548.1 , H89487.1, AW298006.1 , AI374954.1, AA639250.1, AA635049.1, AA192366.1, W27027.1 , R07361.1 , AW504900.1, AI870531.1 , AL046701.1, AL043718.1, AI797903.1 , AA339361.1, AW197070.1, AI652536.1, AI268666.1, AI126656.1, AA644357.1 , AA280749.1, AA157017.1 , AA031654.1, T23989.1, AI554395.1, AA989349.1, AA877743.1 , AA831132.1 , AA506458.1 , AA447099.1 , AW081941.1 , AI808248.1 , AA828419.1 , AA487368.1 , H39920.1 , R72342.1, AW274289.1, AW005902.1, AI962478.1, AI351528.1, AI348589.1, AI198588.1, AI085314.1, AA947454.1, AA866064.1, AA832188.1 , AA433996.1, AA284871.1, N52189.1, H47518.1, AW271235.1, AL042073.1, AI244503.1 , ALl 57387.2, ALl 622724, AC036208.2, AC023766.2, AC037459.1, AC021108.3, ACO 15559.1, ALl 57764.2, AC012300.2, AL353998.3, AL162261.2, AC067955.4, AC058791.2, AC020636.4, AC021103.6, AC060822.2, AC068889.4, AC020604.4, AC067948.3, AC061970.2, AC060764.2, AC044836.2, AC025643.3, AC006534.3, AC068720.1, AC021 193.3, AC016739.2, AC034204.3, AC020900.3, ACOl 1501.5, ACOl 1452.5, AC008622.4, AC008403.5, AC008392.5, AC010354.4, AC010453.3, AC008839.4, AC032035.2, ACOl 151 1.4, AC022954.3, AC068034.1 , AC067979.1, AC012439.4, AC026929.2, AC066599.1, AC063976.1 , AC022311.4, AC009701.3, AC026839.2, AC023134.4, AC021674.3, AC023437.2, AC015992.3, AC015972.3, AC0271 19.2, AC025956.2, ACOl 1473.3, AC023924.2, AC012118.2, AC025372.2, AC025371.2, AC022795.3, AC013331.4, AC024322.2, AC022489.3, AC021132.4, AC017063.5, AC023069.2, AC021287.4, AC010720.2, AC019238.2, AC023287.3, AC012356.3, AC009963.4, AC021922.1, AC009878.3, AC018408.1, AC018431.1, AC013560.2, AL355517.3, AL353648.4, AL049537.36, AL356354.1, AL139010.6, AL355586.4, AL355864.2, AL354683.2, AL353791.2, AL159152.6, AL355132.3, AL355922.1, AL138681.4, AL354867.1, AL161788.4, Z82207.1, AP001405.1, AP000729.1, AL356218.1, AC017099.3, AL356585.1,

SEQ ID NO: 558

ZH1363/T3

AL050302.2, AL163203.2, AL049911.2, NM_014915.1 , AB028997.1, ABOl 1137.2, AL163202.2, AP001464.1, AP000542.1, AL0311 16.1, AL009051.1, AC007094.3, AC007970.3, AC018760.4, NM_003299.1, AC004936.2, U40939.1, AL161957.1, ALl 10120.11, AL078614.2, L42522.1, AP001465.1, X15187.1, AK000712.1, AC003096.2, AL133475.14, AL035690.10, AL035446.4, X03704.1, AW373574.1 , AW614036.1, AW297165.1, AA521089.1, AA296607.1, AI988938.1 , AI920892.1 , AI236531.1 , Al 180434.1 , Al 180260.1 , AH 76501.1 , AA892166.1 , AI058351.1 , AI044283.1 , AA533501.1, AW656081.1, AW656019.1, AW247016.1, AI984814.1, AI904680.1, AL046634.1, AL036452.1, AI770175.1, AI690374.1 , AI446107.1, AA773607.1, AA398033.1, AA056391.1, W44909.1, W26464.1, R62950.1, M61978.1, AW662136.1, AW614443.1 , AW613150.1, AW574899.1, AW574796.1 , AW418540.1, AW418527.1, AW410433.1, AJ281607.1, AW320227.1, AW275258.1 , AW244097.1 , AV271334.1, AW088936.1, AW072295.1, AW005236.1, AI983391.1, AI924665.1 , AV131385.1, AV081079.1, AI538762.1 , AI368143.1, AI31 1542.1, AI302518.1 , AI289573.1, AI200709.1 , AH 92436.1, AI069596.1 , AI057937.1, AI008640.1, AA910838.1 , AA856548.1, AA853969.1, AA768420.1 , AA694241.1, AA631332.1, AA581648.1, AA483705.I , AA477329.1 , AA404339.1, AA291987.1, AA071554.1, N74455.1, N20326.1, F04615.1, Z33598.1, AL157387.1, AL162272.3, AC015940.2, AC008088.2, AC026271.2, AC022596.3, AC036170.2, AC015650.1, AC012256.2, AL133290.3, AC021150.5, AC024252.3, AL353626.1, AC023568.2, AC027253.1, AC009921.4, AC021821.3, AC024170.1, AC022080.5, AL354896.2, AL139091.2, AL138770.2, AL138774.2, AC026029.3, AC023416.3, AC012077.3, AC027625.2, AC027493.2, AC009616.3, AC026081.2, AC025020.2, AC021488.3, AC023977.2, AC012655.4, AC012174.2, AL356259.1, AL121946.14, AL354819.2, AL157695.2, AL009030.9, AL138965.3, AP001534.1, AP001234.1

SEQ ID NO: 559 ZH137/T3

AL163203.2, AL050302.2, AL04991 1.2, AP000026.1 , AP000025.1, NM_014915.1, AKOOl 137.1, AB028997.1, AC007617.10, AC006362.2, AE003447.1 , AJ223186.1 , AC004739.1, AC006355.3, AC006045.2, U48386.1, AF044083.I , AL163224.2, Z70270.1, Z74696.1, AJ001299.1 , U41993.1, D82813.1 , AP001679.1, AP001506.1, AP000961.2, AC005522.2, AC007379.2, AC002528.1, AC006478.2, AC004996.1, AC007099.3, AC005100.2, AC005879.3, AF121898.1, AC005177.1, AC004045.1, AL031586.2, AL022395.2, Z82193.1, Y18930.1, AB025629.1, AI951118.1,

AA828186.1 , AW000914.1 , AI922499.1 , AI871874.1 , AA991162.1 , AA661357.1 , C60377.1 , AA471702.1 , A A095151.1 , AW519678.1 , AW450572.1 , AV282871.1, AI902224.1 , AI781848.1 , AV045752.2, AI311562.1 , AI075925.1 , AA804372.1 , AA701829.1, T49498.1, AC067744.2, AL162272.3, AC021762.3, AC024370.2, AC009401.2, AC027141.1 , AC014239.1, AC036209.2, AC060754.3, AC007131.3, AC061987.1, AC027699.1, AC021187.4, AC013707.2, AC012410.2, AC012542.4, AC012248.2, AC013152.1, AL022284.1, AC027311.2, AC022418.3, AC008885.3, AC027696.2, AC060232.3, AC004932.2, AC044804.1, AC024466.3, AC019259.3, AC006281.6, AC023988.2, AC023399.2, AC016444.2, AC005139.3, AL161730.3

SEQ ID NO: 560 ZH1610/T3

AL163203.2, AL050302.2, AL049911.2, AP000026.1, AP000025.1, NM_014915.1, AKOOl 137.1, AB028997.1, AC007617.10, AE003447.1, AJ223186.1 , AE003494.1, AC004739.1, AC006355.3, AC006045.2, U48386.1, AF044083.1, AL163233.2, AL163224.2, Z70270.1, Z74696.1, U41993.1, D82813.1, AP001679.1, APOO 1688.1, AP001506.1, AP000961.2, D3781 1.1, AC005522.2, AC007379.2, AC002382.1, AC006478.2, AC004996.1. AC007099.3, AC005100.2, AC007100.3, AC005879.3, AC009743.1, AC006253.4, AC005331.1, AC005177.1, AC004045.1, AL133465.30,

AL132766.13, AL109985.2, AL078644.10, AL022395.2, Z82193.1, Y18930.1, AI951118.1, AW000914.1, AI922499.1, AI871874.1, AA991 162.1, AA661357.1, C60377.1, AA471702.1 , AA095151.1, AW814367.1, AW519678.1, AV282871.1, AI902224.1, AV045752.2, AI31 1562.1, AI075925.1 , AA828186.1, AA701829.1, AC067744.2, AL162272.3, AC007351.16, AC009401.2, AC027141.1, AC024370.2, AC014239.1, AC060801.2, AC036209.2, AC060754.3, AC061987.1, AC027699.1 , AC021 187.4, AC013707.2, AC010705.14, AC012410.2, AC012542.4, AC012248.2, AC013152.1 , AL022284.1, AC036208.2, AC022418.3, AC012631.3, AC008885.3, AC022486.3, AC027696.2, AC022395.2, AC060232.3, AC004932.2, AC053528.1, AC044804.1, AC024429.2, AC016916.4, AC023988.2, AC023567.2, AC013320.4, AC016444.2, ACOl 1296.1, AL137863.7, AL355351.2, AL355587.3, AL354884.2, AL161730.3. AL158219.2

SEQ ID NO: 561

ZH171/T3

AL050302.2, AL163203.2, AL04991 1.2, NM_014915.1, AB028997.1 , ABOl 1137.2, AL031116.1, AL009051.1,

AC007094.3, AC018760.4, NM_003299.1, U40939.1, AL161957.1, ALl 10120.11, AL078614.2, L42522.1, AP001465.1, X15187.1, AK000712.1, AC003096.2, AC007970.3, AL133475.14, AL035690.10, X03704.1, AW373574.1, AW614036.1, AI920892.1, AI236531.1, AI180434.1, AI180260.1, AH76501.1, AA892166.1, AI058351.1, AI044283.1, AA533501.1, AW656081.1, AW656019.1 , AW247016.1, AI984814.1, AI904680.1 , AL046634.1, AL036452.1, AI770175.1, AI690374.1, AI446107.1 , C87958.1 , AA773607.1 , AA398033.1 , AA056391.1, W44909.1 , W26464.1 , R62950.1 , M61978.1 , AW614443.1, AW613150.1, AW574899.1, AW574796.1, AW469178.1, AW418540.1, AW418527.1, AW412062.1, AW410433.1, AJ281607.1, AW338178.1, AW320227.1, AW244097.1, AV271334.1, AW088936.1, AW087179.1,

AW072295.1, AW005236.1, AI983391.1, AI972424.1, AI950371.1, AI924665.1, AI784583.1, AV131385.1, AI684965.1, AI538762.1, AI460172.1, AI368143.1, AI311542.1, AI302518.1, AI289573.1 , AI192436.1, AI093327.1, AI069596.1, AI057937.1, AI025802.1, AI008640.1, AA970354.1, AA910838.1, AA856548.1, AA853969.1, AA768420.1 , AA631332.1, AA581648.1, AA483705.1, AA404339.1, AA168585.1, AA151117.1, AA150449.1, AA149652.1, AA136980.1, AA101607.I , W73028.1, N74455.1, N20326.1, H97559.1, H96023.1, AL157387.1, AL162272.3, AC015940.2, AC008088.2, AC026271.2, AC022596.3, AC015650.1, AC012256.2, AC023067.3, AL133290.3, AL161912.3, AC023556.1, AL354819.2, AL157695.2, AL138965.3, AC023568.2, AC027253.1, AC009921.4, AC021821.3, AC024170.1 , AC022080.5, AC010563.3, AL139091.2, AL138770.2, AL138774.2, AL133322.3, AC023416.3, AC027493.2, AC009616.3, AC021384.3, AC025020.2, AC021488.3, AC021379.3, AC021617.4, AC023977.2, AC012655.4, AC012174.2, AL356259.1, AL009030.9, AP001234.1

SEQ ID NO: 562

ZH193 T3

AC002497.1, AC006360.2, AC005323.1, AC008123.9, AL163242.2, Z70232.1, AP001697.1, AP001600.1, AP001599.1, AC007312.1 , AC007938.1, AF235098.1, AC003084.1, AF126403.2, AC005874.3, AF134471.1, AC005971.5, AC006600.4, AC005823.1, AF024496.1 , AC002525.1, AL022162.1, X79283.1, AC007349.1, AFl 17341.1 , AC008757.5, AF208389.1 , AF205586.1, AC002044.1, AC002530.1, AC006364.3, AC005820.1, AC007488.15, AFl 18865.1, AFl 18859.1, AC007436.1 , AFl 18864.1, AFl 18863.1, AFl 18861.1 , AC006522.5, AC000015.2, AC004816.1, AC006256.1, AC005669.1, AL136452.7, AL023856.1, AL008721.1, Z99916.1, Z81479.1, AL034416.1, AL031733.3, AL022398.1 , AL008634.1 , AL030995.1 , ALl 11626.1 , U58755.1 , AP000815.1, AW797580.1 , AI473891.1, AA368397.1 , AA306548.1, AC034129.2, AC040905.2, AC026033.3, AC013336.7, AP001813.1, AP001354.1, AC067739.3, AC023891.7, AC015970.4, AC044856.2, AC034233.3, AC026434.2, AC016599.3, AC008566.3, AC016173.2, AC067715.1 , AC027098.2, AC026858.2, AC016250.3, AC016039.3, AC025683.2, AC025361.2, ACOl 1686.3, AC016916.4, AC025207.2, AC012513.4, ACOl 1245.3, AC015721.2, AC010936.2, AC016010.1, AC010733.1,

AL355586.4, AL354820.3, AL136138.1 , AP002010.1, AP001834.1, AP00150I .1, AC012041.8, AC066613.2, AC009148.6, AC068045.1, AC067795.1, AC019140.3, AC010139.3, AC044789.1, AC026975.2, AC020779.3, AC021880.2, AC016721.4, AC020755.2, AC021708.2, AC024159.1, AC022612.1, AF188028.1, AL136124.8, AL135786.8, AL162452.3, AL139122.3, AL138708.2, AC048378.2, AC025178.3, AC022444.3, AC068557.1, AC067850.1, AC034149.2, AC037196.1, AC022778.3, AC024030.2, AC016441.4, AC023453.1 , ALl 39231.4, AL356459.1, AL139248.3, AL138724.2, AL136106.2, AP001536.1

SEQ ID NO: 563 ZH193/T7 AL050302.2, AL163203.2, AL049911.2, NMJH4915.1, AB028997.1, ABOl 1137.2, AF090187.1, AL009051.1,

AL138654.1, AP000365.1 , AP000548.1, ACOl 1661.5, AF035938.1, AP001302.1, AC004936.2, AC006157.2, U40160.1, AC009402.3, AC004142.1, AC009513.2, X17051.1, AW373574.1, AW170035.1, AL046701.1, AA759177.1, AI957948.1, C87958.1, T38511.1, AW628933.1, AW469178.1, AW338178.1, AW331 138.1, AW320227.1, AW171900.1, AW087179.1, AW052899.1, AW042526.1, AI972424.1, AI950371.1, AI920706.1, AI784583.1, AU072482.1, AI684965.1 , AI486778.1, AI460172.1, AI148480.1, AI093327.1, AI025802.1, AA970354.1, AA708873.1, AA151117.1, AA150449.1, AA149652.1, AA136980.1, AA101607.1, AA071350.1, W73028.1, W35448.1, H97559.1, H96023.1, AL157387.1, AL162272.3, AC015940.2, AC022596.3, AC008088.2, AC040973.2, AC023067.3, AC016739.2, AC026271.2, AC025384.2, AL161912.3, AL137219.1, AL049185.4, AC068690.1, ACOl 1211.3, AC015737.4, AC019255.2, AC013414.2, AL158074.5, AL157695.2, AL138965.3, AC008390.6, AC023337.3, AC034160.3, AC026081.2, AC025355.2, AC016215.4, AC019042.3, AC021755.4, ACOl 1286.4, AL356312.1

SEQ ID NO: 564

Group ZH 139

AL163203.2, AL050302.2, AP000026.1, AP000025.1, AL04991 1.2, NM_014915.1 , AKOOl 137.1, AB028997.1, AC007617.10, AE003447.1, AE003494.1, AC007028.3, AC002433.1, AC004739.1, AC006355.3, AC009513.2,

AC004902.2, AC006045.2, U48386.1, AF027390.1, AF044083.1, AL163254.2, AL163233.2, AL163224.2, Z70270.1, Z74696.1, U41993.1, D82813.1, AP001679.1, AP001709.1, AP001688.1, AP001506.1, AP000961.2, AP000205.1 , AP000245.1, AP000127.1, AC005522.2, AC007379.2, AE003064.1, AC004506.1, AC002382.1, AC004823.1, AC006478.2, AC004996.1 , AC007099.3, AC005100.2, AC007100.3, AC005879.3, AC009743.1, AC006253.4, AC005331.1, AC005177.1, AC004045.1, AL133465.30, AL163912.1 , AL132766.13, AL109985.2, AL096816.12,

AL078644.10. Z81103.1 , Z81562.1, AL022395.2. Z82193.1, Y18930.1. D64003.1, M17109.1, AI951118.1, AW000914.1 , AI922499.1, AI871874.1, AA991162.1, AU045123.1, AU021965.1 , AU021770.1, C87414.1, C85160.1, AA667026.1, AA661357.1, C60377.1, AA471702.1, AA095151.1, AW519678.1, AV282871.1, AI902224.1, AV045752.2, AI314885.1, AI31 1562.1, AI075925.1, AA828186.1, AA812289.1, AA701829.1, AA429403.1, AA426874.1, AA389848.1, AC067744.2, AL162272.3, AC007351.16, AC021721.3, AC013272.2, AC009401.2, AC018892.2, AC027141.1, AC024370.2, AC017099.3, AC022175.1, ACO 14239.1 , AC036220.2, AC036209.2, AC009143.4, AC009123.5, AC027728.2, AC027530.2, AC060754.3, AC062032.1, AC007131.3, AC061987.1, AC019064.3, AC027699.1, AC009833.3, AC016080.3, AC022264.2, AC021187.4, AC013707.2, AC010705.14, AC020617.2, AC012593.3, AC012410.2, AC012542.4, AC012248.2, AC013152.1, AL139332.3, AP001455.1 , AL022284.1

SEQ ID NO: 565

ZH139/T3

AL163203.2, AL050302.2, AL049911.2, AP000O26.1, AP000025.1, NM_014915.1, AKOOl 137.1, AB028997.1,

AC007617.10, AE003447.1, AE003494.1, AC007028.3, AC002433.1, AC004739.1, ACO06355.3, AC009513.2, AC004902.2, AC006045.2, U48386.1, AF044083.1, AL163254.2, AL163233.2, AL163224.2, Z70270.1, Z74696.1,

U41993.1, D82813.1, AP001679.1, AP001709.1, AP001688.1, AP001506.1, AP000961.2, AP000205.1, AP000245.1, AP000127.1, AC005522.2, AC007379.2, AE003429.1, AC004506.1, AC004823.1, AC006478.2, AC004996.1, AC007099.3, AC005100.2, AC007100.3, AC005879.3, AC005331.1 , AC005177.1, AC004045.1, AL133465.30, AL163912.1, AL132766.13, AL109985.2, AL096816.12, AL078644.10, Z81103.1, AL022395.2. Z82193.1, Y18930.1, D64003.I, M17109.1, AI951118.1, AW000914.1. AI922499.1. AI871874.1, AA991162.1, AA661357.1, C60377.1,

AA471702.1, AA095151.1, AW519678.1, AV282871.1, AI949555.1, AI902224.1, AV045752.2, AI311562.1 , AI075925.1, AA828186.1, AA701829.1, AA429403.1, AA389848.1, W00819.1, AC067744.2, AL162272.3, AC007351.16, AC009401.2, AC018892.2, AC027141.1, AC024370.2, AC017099.3, AC022175.1, AC014239.1 , AC036220.2, AC036209.2, AC027728.2, AC027530.2, AC060754.3, AC062032.1, AC007131.3, AC061987.1, AC019064.3, AC027699.1, AC009833.3, AC022264.2, AC013707.2, AC020617.2, AC012593.3, AC012410.2, AC012248.2, AC013152.1, AP001455.1, AC046133.3, AC046187.2, AC008885.3, AC060232.3, AC013361.4, AC004932.2, AC044804.1, ACOl 1186.3, AC019207.3, AC016061.3, AC016916.4, AC023470.2, AC016500.3, AC023567.2, AC023399.2, AC016444.2, AC014380.1, AL356132.3, AL354884.2

SEQ ID NO: 566

ZH1402 T3

AL163203.2, AL050302.2, AP000026.1, AP000025.1, AL049911.2, NM_014915.1, AKOOl 137.1, AB028997.1,

AC007617.10, AE003447.1, AJ223186.1, AE003494.1, AC004739.1, AC006355.3, AC006045.2, U48386.1, AF027390.1, AF044083.1, AL163233.2, AL163224.2, Z70270.1, Z74696.1, U41993.1, D82813.1 , AP001679.1, AP001688.1, AP001506.1, AP000961.2, AC005522.2, AC007379.2, AC006478.2, AC004996.1, AC007099.3, AC005100.2, AC007100.3, AC005879.3, AC005331.1, AC005177.1, AC004045.1, AL133465.30, AL132766.13, AL109985.2, AL078644.10, Z81103.1 , Z81562.1 , AL022395.2, Z82193.1 , Yl 8930.1 , AI951 1 18.1, AW000914.1 , AI922499.1 , AI871874.1, AA991162.1, AA661357.1, C60377.1 , AA471702.1, AA095151.1, AW519678.1, AV282871.1 , AI902224.1, AV045752.2, AI311562.1, AI075925.1, AA828186.1, AA812289.1, AA701829.1 , AC067744.2, AL162272.3,

AC007351.16, AC021721.3, AC009401.2, AC027141.1, AC024370.2, AC014239.1, AC036209.2, AC060754.3, AC062032.1, AC007131.3, AC061987.1, AC027699.1, AC016080.3, AC021187.4, AC013707.2, AC012410.2, AC012542.4, AC012248.2, AC013152.1, AL139332.3, AP001455.1, AL022284.1 , AC022418.3, AC008885.3, AC027696.2, AC004932.2, AC019259.3, AC006281.6, AC023988.2, AC016444.2, AC005139.3, AL161730.3

SEQ ID NO: 567

ZH1402 T7

AL050302.2, AL163203.2, AL049911.2, NM_014915.1, AB028997.1, ABOl 1 137.2, AF090187.1, AC004499.1,

AL009051.1, AL138654.1, AP000365.1, AP000548.1, ACOl 1661.5, AP001302.1, AC004936.2, AC006157.2, AL161940.6, U40160.1, AC008912.4, AC004142.1, AC006996.2, AC009513.2, AC005358.1 , AL161595.2, AL022605.3, X70810.1 , AL035531.17, AW373574.1 , AWl 70035.1, AA759177.1, AL046701.1, AV242491.1 , AV228746.1, AI957948.1, C87958.1, AA837612.1, AA837592.1, AW469178.1 , AW331138.1, AW320227.1, AWl 71900.1, AW087179.1, AW052899.1, AW042526.1 , A1972424.1, AI950371.1, AI920706.1, AI784583.1, AU072482.1, AU071886.1, AI684965.1, AI460172.1, AH48480.1, AI093327.1, AI025802.1, AA990150.1, AA970354.1, AA708873.1, AA151117.1, AA150449.1, AA149652.1, AA136980.1, AA101607.1, AA071350.1, W73028.1, H97559.1, H96023.1, AL157387.1, AL162272.3, ACOl 5940.2, AC022596.3, AC008088.2, AF228659.1 , AC023067.3, ACO 16739.2, AC025384.2, AL354819.2, AL157695.2, AL138965.3, AL137219.1, AL049185.4, AC068690.1, AC026427.2, AC008390.6, AC026081.2, AC010785.3, AC016215.4, AC019042.3, AC021755.4, AC007342.2, AC012174.2, AC018792.2, AL356312.1, ALl 61912.3

SEQ ID NO: 568

ZH154 T3

AP000025.1, AP000026.1, AL163203.2, AL050302.2, AL049911.2, NM_014915.1, AKOOl 137.1, AB028997.1 ,

AC007617.10, AE003447.1, AJ223186.1, AC004739.1, AC006355.3, AC006045.2, U48386.1, AF044083.1, AL163224.2, Z70270.1, Z74696.1, U41993.1, D82813.1 , AP001679.1, AP001506.1, AP000961.2, AC005522.2, AC007379.2, AE003459.1, AC006478.2, AC007099.3, AC005879.3, AC005650.1, AC005331.1, AC004045.1, ALl 63291.2, AL132766.13, AL096867.15, AL078644.10, Z22180.1, AL021406.1, AL022395.2, Z82193.1, Y18930.1, AJ238787.1, AJ238786.1, AP001746.1, AP001623.1, AI951 1 18.1 , AW000914.1, AI922499.1, AI871874.1, AA991162.1 , W08579.1, AW030402.1 , AA661357.1 , C60377.1 , AA471702.1 , AA095151.1 , AW61 1472.1 , AW519678.1 , AW449940.1 , AW394816.1, AV282871.1, AI902224.1, AV121 102.1, AV064061.1, AV051246.1, AV045752.2, AI311562.1,

AU045123.1, AI137187.1, AU021965.1, AU021770.1, AI075925.1, C87414.1, C85160.1, AA828186.1, AA701829.1, AA667026.1, AA015732.1, AC067744.2, AL162272.3, AC007351.16, AC027141.1, AC024370.2, AC022175.1, AC014239.1, AC035145.2, AC068481.1, AC061987.1, AC027699.1, AC012410.2, AC012248.2, AC013152.1, AP001455.1, AC046187.2, AC026428.2, AC022418.3, AC010622.3, AC008885.3, AC027696.2, AC004932.2, AC023988.2, AC016444.2, ACOl 1128.2, AF186999.1, AC005139.3

SEQ ID NO: 569 ZH154/T7 AL163203.2, AL050302.2, AL049911.2, AP000542.1, AL163202.2, AP001464.1, NM_014915.1, AB028997.1,

ABOl 1137.2, AF077534.1, AL009051.1, U32775.1, AL161957.1 , AL110120.i l, AL078614.2, U19872.1, AP001465.1 , AK000712.1, AC008154.6, AC005670.1, AL133475.14, AL021633.2, AL096861.9, Z84482.1, AL080283.1, AW373574.1, AI951118.1, AW297642.1 , AA579752.1 , AI989660.1 , AI825717.1 , AI084496.1 , AA331953.1 , AW614036.1 , AI236531.1, AI180434.1, AH 80260.1, AI176501.1, AA892166.1, AI058351.1, AI044283.1, AA464382.1, AW656081.1, AW656019.1, AW564696.1, AI984814.1, AV127940.1, AI770175.1, AI446107.1, AA736439.1, AA219203.1, R62950.1, AW578955.1, AW541472.1, AW540560.1, AW363481.1, AV350817.1, AV346364.1, AV322534.1, AI955034.1, AI790539.1 , AV131385.1, AI647944.1, AI631727.1, AI583901.1, AI368143.1 , AI324262.1, AI193904.1, AI168669.1, AI133530.1 , AI086364.1, AI065683.1, AI008640.1, AA910838.1, AA738088.1, AA623276.1 , AA554531.1 , AA533501.1, AA518668.1, AA423412.1, AA250678.1, AA222830.1, AA046147.1, AA046322.1, W54181.1, N72190.1, Z33598.1, AL157387.1, AC024252.3, AL353626.1, AC036170.2, AL162272.3, AC067744.2, AC015940.2, AC008088.2, AC026271.2, AC022596.3, AP000776.1, AL133290.3, ACOl 1254.3, AL355499.5, AC024107.9, AC012435.6, ACOl 1040.3, AC010959.3, AC015650.1, AL133322.3, AP000872.2, APOOl 133.1, AC048371.2, AC068183.1, AC027493.2, AC025485.2, AC021488.3, AC010994.9, ACOl 1829.2, AL354771.1

AL163203.2, AL050302.2, AL049911.2, AP000026.1 , AP000025.1 , NM H4915.1, AKOOl 137.1, AB028997.1,

AC007617.10, AE003447.1 , AJ223186.1 , AE003494.1, AC004739.1, AC006355.3, AC006045.2, U48386.1, AC005177.1 , AF044083.1, AL163233.2, AL163224.2, Z70270.1, Z74696.1, U41993.1, D82813.1, AP001679.1, AP001688.1,

AP001506.1 , AP000961.2, AC005522.2, AC008430.3, AC007379.2, AE003675.1, U91327.1, AC006478.2, AC004996.1, AC007099.3, AC005100.2, AC007100.3, AC005879.3, AC006952.6, AC005331.1, AC004045.1, AL133465.30, AF016685.1, AL132766.13, AL109985.2, AL078644.10, AL030999.2, AL022395.2, Z82193.1, Y18930.1, AI9511 18.1, AW000914.1, AI922499.1, AI871874.1, AA991162.1, AA661357.1 , C60377.1, AA471702.1, AA095151.1, AW819103.1, AW519678.1, AV282871.1, AI902224.1 , AV045752.2, AI31 1562.1, AI075925.1, AA828186.1, AA701829.1 , AC067744.2, AL162272.3, AC009401.2, AC027141.1, AC024370.2, AC014239.1, AC036209.2, AC012622.4, AC024184.1, AC061987.1 , AC027699.1, AC013707.2, AC012410.2, AC019081.1, AC012248.2, AC013152.1, AL121993.6, AP001455.1, AL022284.1, AC062015.2, AC046187.2, AC022418.3, AC012631.3, AC008885.3, ACOl 1734.4, AC025113.2, AC027696.2, AC004932.2, AC046156.1, AC026529.2, AC026035.2, ACOl 1710.2, AC016916.4, AC012549.2, AC023988.2, AC023567.2, AC009972.4, AC016444.2, AC011296.1, AL356132.3, AL355351.2

SEQ ID NO: 571

ZH 185/17

AL050302.2, AL163203.2, AL04991 1.2, NM_014915.1, AB028997.1, ABOl 1137.2, AL009051.1, AL138654.1, AP000365.1, AP000548.1, AC011661.5, AP001302.1, AE003737.1, AC004936.2, AC006157.2, AC006557.2, Z99291.1, U40160.1 , AC008526.5, AF156143.1, AC009402.3, AC004142.1 , AC009513.2, AC006475.3, AC005760.1, AC005358.1, AL161595.2, AL161592.2, AL022605.3, X70810.1, U58744.1, AL035538.1, X68658.1, Zl 1874.1, X17051.1, AW373574.1, AW170035.1, AL046701.1, AA759177.1, AI957948.1, C87958.1, AW469178.1, AW415249.1, AW338178.1 , AW331 138.1, AW320227.1, AW171900.1, AW087179.1, AW052899.1, AW042526.1, AI972424.1, AI950371.1, AI920706.1, AI784583.1, AU072482.1, AI684965.1, AI460172.1 , AH 48480.1, AI093327.1, AI025802.1, AA970354.1 , AA708873.1, AA530141.1, AA151 117.1, AA150449.1, AA149652.1, AA136980.1, AA101607.1, AA071350.1, W73028.1, H97559.1, H96023.1, AL157387.1, AL162272.3, AC015940.2, AC022596.3, AC008088.2, AL354819.2, AL157695.2, AL138965.3, AC023067.3, AC016739.2, AC026271.2, AC025384.2, AL161912.3, ALI37219.1, AL049185.4, AC068690.1 , AC026427.2, AC010248.4, AC024590.2, ACOl 1578.3, AC016684.1 , AC022124.3, AC008390.6, AC026081.2, AC025364.2, AC016215.4, AC019042.3, AC021755.4, ACOl 1286.4, AL356312.1, AL137221.4, AL137123.3

SEQ ID NO: 572 Group ZH 184 AL050302.2, AL04991 1.2, AL163203.2, AL163202.2, AP001464.1, AP000542.1, AP000026.1, AP000025.1,

NM_014915.1, AB028997.1, AKOOl 137.1 , AC004902.2, AL009051.1, AJ223186.1, AC012654.2, U48386.I , AF044083.1 , AL163224.2, Z74696.1 , AP001679.1, NM_013469.1, AE003492.1, AC007250.2, AL163228.2, AL132766.13, U65986.1, APOOl 683.1 , X95911.1, AI951118.1 , AW373574.1 , A W297642.1 , AI989660.1 , AI825717.1 , AA579752.1 , AI084496.1 , AA331953.1, AW000914.1, AI922499.1 , AI902224.1, AI871874.1, AA991162.1, AA464382.1, AW564696.1 , AW108479.1, AI984814.1, AV127940.1, AI770175.1, AA736439.1, AA661357.1 , AA660701.1, C60377.1, AA471702.1, AA219203.1, AA095151.1, AW208236.2, AW578955.1 , AW541472.1, AW540560.1, AW519678.1, AW418577.1, AW403036.1, AV346364.1, AV322534.1, AV282871.1, AV382738.1, AI935447.1, AI808313.1 , AI790539.1, AI754384.1, AI651636.1 , AI647944.1 , AI631727.1 , AI591085.1 , AI583901.1 , AI478844.1 , AU005907.1 , AI360552.1 , AI324262.1 , AI168669.1, AI150310.1, AI133530.1, A1086364.1, AI075925.1, AI065683.1, AA828186.1, AA746252.1, AA738088.1, AA660895.1, AA660377.1, AA623276.1, AA518668.1, AA423412.1, AA280548.1, AA250678.1, AA222830.1,

AA151455.1 , AA046147.1, AA046322.1, W54181.1 , W16804.1. N72190.1, AC067744.2, AL157387.1, AC024252.3, AL353626.1, AC036170.2, AL162272.3, AC008386.5, AC021384.3, AL356259.1, AP000776.1, AC017005.4, AC026271.2, AC008088.2, AC027713.2, AC007131.3, AC027699.1, AL139091.2 SEQ ID NO: 573 Group ZH204

M33272.1 , M62890.1 , U09474.1 , U09472.1 , U09470.1 , U85195.1 , AE000658.1 , U73702.1 , AL022576.1 , U29376.1 , U22025.1, U22019.1, U22017.1, AC000030.4, NM_002020.1, AF144731.1, AF177536.1, AC006276.1, AF000299.1 , L41927.1, AL163214.2, Z74581.1, Z49936.1, U22183.1, Z71646.1, U43143.1, AB004535.1, AP001669.1, M83665.1, Z17240.1, X62534.1, X69878.1, X68203.1, M15825.1, D78303.1, AE003556.1, AE003513.1 , AE003508.1, AF161775.1, AF161773.1, AF161772.1, AF161771.1, AF161770.1, AF161769.1, AF161768.1 , AF161767.1, AF161766.1, AF161765.1 , AF161764.1, AF161763.1, AC007529.5, M99575.1, AL161590.2, AL136538.1, AL035412.22, Z66525.1, Z99707.1, AW415958.1, AA312591.1, AW748894.1 , AW748893.1, AW748903.1, AI098848.1, AA007643.1, AA084882.1, AU080777.1, AA263149.1, AI585542.1, AA546260.1, AA127538.1, AI505847.1, AW106399.1, AA285232.1 , AW456026.1, AI384994.1, AI588808.1 , AA981002.1, AW866948.1, AW837857.1 , AW803636.1, AW802295.1, AW799320.1, AW799305.1, AW799215.1, AW795369.1, AW795295.1, AW795283.1, AW795203.1 , AW673780.1, AW608831.1 , AW605184.1, AW605160.1, AW605135.1, AW571487.1, AW468394.1, AW440973.1, AW403024.1, AW291824.1, AW204191.1 , AW327783.1, AW327724.1, AW167852.1, AI954999.1, AI954175.1, AI905275.1, AI831782.1, AV159089.1, AI745038.1, AI683060.1 , AA818062.1, AI380618.1, AI373115.1, AI355746.1 , AI338618.1, AI336359.1, AI133236.1, All 26474.1, AI022067.1, AA822594.1 , AA5805I6.1, AA426205.1, AAl 72425.1 , C02000.1, W60824.1, T52063.1, AW876754.1 , AW703947.1 , AW568633.1, AI988524.1, AV197798.1, AV197063.1, AV195631.1 , AV192769.1, AV187686.1, AI738431.1, AV031963.1, AI441075.1, AA684640.1, AA611503.1, C60926.1, AA585860.1, C44543.1, AA124367.1, AA050702.1, AL138878.3, AL139095.3, AC010893.4, AL109933.20, AC063933.3, AC025925.2, AC024364.2, AC021185.2, AC023350.1, AC012452.3, AC021814.2, AC025520.2, AC016723.4, AC022335.6, AC024911.1, AC018551.1, AC012041.8, AC010184.9, AC068985.2, AC022095.4, ACOl 1544.5, AC026167.2, AC027631.2, AC0I3364.7, AC008026.2, AC013350.6, AC022270.3, AC010892.3, AC009588.4, AC058333.2, AC068808.4, AC015933.5, AC012000.2, AC010708.9, AC010037.4, AC012595.3, AL160153.4, AL157891.4 SEQ ID NO: 574 ZH092/T3

AL050302.2, AL049911.2, AL163203.2, AL163202.2, AP001464.1, AP000542.1, AP000026.1, AP000025.1 , NM H4915.1, AB028997.1 , AKOOl 137.1, AC004902.2, AL009051.1 , AF077534.1, AC023602.5, AC012654.2, U40939.1, AL133162.2, AL161957.1, U41993.1, AK000712.1, NM_013469.1, AC004079.1, AC005737.1 , ALl 63228.2, Z69637.1, U65986.1, L09228.1, AP001683.1, X95911.1, AI951118.1, AW373574.1, AW297642.1, AI989660.1, AI825717.1, AA579752.1, AI084496.1, AA331953.1, AI902224.1, AA464382.1, AW564696.1, AW108479.1, AI984814.1, AV127940.1, AI770175.1, AA736439.1, AA660701.1, C60377.1, AA219203.1, AW208236.2, AW578955.1, AW541472.1, AW540560.1, AW519678.1, AW418577.1, AW363481.1, AW403036.1, AW262107.1, AV346364.1, AV322534.1 , AI935447.1, AI808313.1, AI790539.1, AI754384.1, AV045752.2, AI671778.1, AI647944.1 , AI631727.1, AI591085.1, AI583901.1, AI478844.1, AI360552.1, AI324262.1, AH68669.1, AI150310.1, AI133530.1, AI086364.1, AI065683.1, AA746252.1, AA738088.1, AA724030.1, AA660895.1, AA660377.1, AA623276.1, AA518668.1, AA423412.1, AA280548.1, AA250678.1, AA222830.1, AA151455.1, AA046147.1, AA046322.1, W54181.1, W16804.1 , N72190.1, AC067744.2, AC024252.3, AL353626.1 , ALl 57387.1, AC036170.2, AL162272.3, AC008386.5, AC021384.3, AL356259.1, AP000776.1, AC017005.4, AC026271.2, AC008088.2, ACOl 1254.3, AC012582.3, AC013729.3, AC024107.9, AC027713.2, ACOl 1040.3, AC013733.3, AC055712.2, AC022139.3, AC021488.3, AC022773.2, AC023402.2, ACOl 1829.2, AL121955.9

SEQ ID NO: 575 ZH092/T7 AL035413.19, AL136295.2, AL163274.2, AP001729.1, AP000154.1, AC016025.12, AC025588.1, AC005779.1,

AC006285.11, AC007845.12, AC002470.17, AC007919.18, AC007308.13, AC005332.1, AL163262.2, AP001717.1, AP000191.1, AP000553.1, APOOOl 15.1 , AL163290.2, AP001745.1, ALl 17258.2, AC007378.4, AC004841.2, AL022329.9, ACOl 1455.6, AC000004.1, AC007216.2, AC000353.27, U95742.1, AC005486.2, AC005048.2, AC005102.1, AC005057.2, AC006965.3, AC002310.1 , AC005089.2, AC005288.1, AL163261.2, AL031658.11, AL109758.1, AL049776.3, AL031295.1, AL008718.23, AL078611.1, AP001716.1, Z79997.1, AC005049.2, AC005565.1, AC007227.3, AC003038.1, AC005736.1 , AC005527.3, AC004653.1, AL034380.26, AL022323.7, AC006028.3, AC006038.2, AC002045.1, AC004491.1, AF088219.1, AC004832.3, AC004922.2, AC004990.1, AC00501 1.2, AC005412.5, AC010170.3, AC004878.2, AC005088.2, AC006312.8, AC006120.1, AC004675.1, AC004647.1, AL163216.2, AL133455.2, AP001671.1, AP000555.1, AC004217.1, AL163293.2, AL096775.10, AL022476.2, Z78022.1, AP001748.1, AC005875.2, AC005488.2, AC007792.1, Z85986.1, AC004826.3, AC002401.1, AC004858.2, AC006014.2, AC005072.2, AC003026.1, AC003003.1, AC005694.3, AF109907.1, AC003688.1, AC002558.1, AL034549.16, AL049758.11, AW295538.1, AA634538.1, AA634486.1, AI767517.1, AA400984.1, AWl 70035.1 , AI765724.1, D57390.1, AI821400.1, AA664700.1, F00440.1, AI914872.1, AI817516.1, AI355556.1, AI287627.1, AI287541.1, AW276817.1, AI873990.1, AI537955.1, AI284640.1, AA584637.1, AA580808.1, AA468022.1 , W79504.1 , AW872676.1 , AW473163.1, AW043680.1, AI972203.1, AI708009.1, AI085719.1, AA947364.1, AA618349.1, AA484373.1, AA225246.1, AA135357.1, N84237.1, T57267.1, AW872575.1, AW862496.1, AW860542.1, AW500226.1, AW103769.1, AW090312.1, AI523897.1, AA745406.1, AA525151.I , AA483330.1, AI633942.1, AAl 00599.1, W60328.1, AW071163.1, AI819574.1, AA745485.1, AA745475.1, AA724333.1, AA281435.1, AA459749.1, N32813.1, AW022897.1, T05070.1, AW440215.1, AW274772.1, AW238120.1, AW238092.1, AI924251.1, AI791819.1, AA570386.1, AA514295.1, AA229609.1, AA228418.1, AA228330.1, AW504900.1, AI361525.1, AA729780.1, AA129446.1, W68362.1, AA947809.1, AA769402.1, AW440545.1, AA639073.1, AA632036.1, W68497.1, N92756.1, H60533.1, AI014656.1, AA604333.1, AA179944.1, N35418.1, AI821596.1, AA569183.1, R66544.1, AA747305.1, AA742424.1, AA722372.1, AA487567.1, AA483284.1, W68229.1, ALl 19729.1, AI799327.1, AW085605.1, AL157387.2, AC010319.6, AC010189.4, AC069214.1 , AC068533.2, ACOl 1189.4, AC016688.4, AC021 196.3, AC004555.2, AL137120.5, AL356356.1, AC067749.2, AC016586.4, AC010321.4, AC009171.4, AC016700.2, AC020723.3, AC022621.4, AL136231.5, AL096708.33, AL160172.4, AL161728.2, AL354733.4, AC010614.4, AC026763.5, AC025772.3, ACOl 1492.5, AC019220.2, AL137853.8, AL158209.4, AL157871.1 , AC055806.3, ACOIOI 88.6, AC012018.7, AC055782.2, ACOl 1085.4, AC020908.5, ACOl 1495.3, AC019360.3, AC026397.2, AC013728.3, AC019167.3, AC021778.3, AC015589.3, AJ239320.3, AL139143.4, AL355312.3, AL354668.1, Z97197.3, APOOl 160.1, AC008761.3, AC007595.3, AC008427.5, AC013436.3, AC010184.9, AC024215.7, AC02551 1.2, AC008569.5, AC008760.4, AC021138.4, AC027709.2, AC007366.3, AC022021.2, AC004387.1, AL137139.3, AC018663.2, ACOl 1598.6, AC044900.2, AC026046.4, AC025289.2, AC020931.3, AC012626.4, AC008946.4, AC027726.2, AC004867.2, AC019260.4, AC019125.4, AC019166.4, ACOl 1432.2, AC005056.1, AL138895.7, AL034372.30, AL354740.4, AL158048.2, AL354677.1, AL158075.3, AC022038.2, AC018639.6, AC024571.2, AC008540.3, AC023583.2, AC007637.7, AC009562.5, AC007163.2, AC004604.3, AC005098.1, AL158172.2, AL158817.2, Z82199.1, AC025555.2

SEQ ID NO: 576 ZH112/T3 AL050302.2, AL049911.2, AL163203.2, AL163202.2, AP001464.1, AP000542.1, AP000026.1, AP000025.1 ,

NM_014915.1, AB028997.1, AL009051.1, AC004902.2, AF077534.1, AL035690.10, AC015600.6, AC023602.5, AC012654.2, AC006355.3, U40939.1, AL133162.2, D87000.2, AE003492.1, AC004079.1, AF061415.1, AF061410.1, AF061409.1, AF061408.1, AF061407.1, AF061406.1, AF061405.1, AF061404.1 , AF061403.1, AF061402.1, X95911.1, X63956.1, AL132639.2, AL139078.2, Y08926.1, AI9511 18.1, AW297642.1, AI989660.1 , AI825717.1, AW373574.1, AA521089.1, AA579752.1, AI084496. I, AA331953.1, AA464382.1, AA296607.1, AW564696.1, AV127940.1, AA736439.1, C60377.1, AA219203.1, AW578955.1, AW541472.1, AW540560.1 , AW418577.1, AW363481.1 , AW403036.1 , AW297165.1, AW262107.1, AV346364.1 , AV322534.1, AI935447.1, AI790539.1, AI754384.1, AI671778.1, AI647944.1, AI631727.1, AI591085.1, AI583901.1, AI478844.1, AI360552.1, AI324262.1, AI168669.1, AI150310.1, AI133530.1, AI086364.1, AI065683.1, AA746252.1, AA738088.1, AA724030.1, AA623276.1, AA518668.1, AA423412.1, AA280548.1, AA250678.1, AA222830.1, AA151455.1, AA046147.1, AA046322.1, W54181.1, W16804.1, N72190.1, H15988.1, Z42190.1, AL157387.2, AC067744.2, AC024252.3, AL353626.1, AC036170.2, AL162272.4, AC008386.5, AC021384.3, AL356259.1, AP000776.1, AC017005.4, AC008429.3, AC025103.1, ACOl 1254.3, AC020682.2, AL353609.2, AC021821.3, AC021076.3, AC027716.2, AC036102.2, AC013452.3, AL139091.3, AL121955.9. AL353894.3

SEQ ID NO: 577

Z112/T7

AL050302.2, AL163203.2, AL04991 1.2, NM_014915.1, AB028997.1, ABOl 1 137.2, AL009051.1, AL138654.1,

AP000365.1, AP000548.1, AC011661.5, AP001302.1, AC004936.2, AC006157.2, AF090187.1 , AC006557.2, Z99291.1 , AL031599.1, U40160.1, AC008526.5, AF156143.1, AC009402.3, AC004142.1, AC009513.2, AC006475.3, AC005760.1, AC005358.1, AL161595.2, Z11874.1, X70810.1, AL022605.3, AJ251973.1, U58744.1, X68658.1. X17051.1, AW373574.1, AW170035.1, AL046701.1, AA759177.1, AI957948.1, C87958.1, AW469178.1, AW331138.1, AW320227.1, AW171900.1, AW087179.1, AW052899.1, AW042526.1, AI972424.1, AI950371.1, AI920706.1, AI784583.1, AU072482.1, AI684965.1, AI460172.1, AII48480.1, AI093327.1, AI025802.1, AA970354.1, AA708873.1, AA151 117.1, AA150449.1, AA149652.1, AA136980.1, AA101607.1, AA071350.1, W73028.1, W35448.1, H97559.1,

H96023.1, AL157387.2, AL162272.4, AC022596.4, AC015940.2, AC008088.2, AL354819.2, AL157695.2, AL138965.3, AC026271.3, AC023067.3, AC016739.2, AC025384.2, AL137219.1, AC068690.1, AC026427.2, AC010248.4, AC024590.2, AC018440.3, AC016684.1, AC025076.3, AC060784.2, AC022124.3, AC008390.6, AC026081.2, AC016215.4, AC019042.3, AC009499.2, AC021755.4, AC020749.2, AC012174.2, ACOl 1286.4, AL132794.11, AL356312.1 , AL161912.3, AP001541.1

SEQ ID NO: 578

ZH1219/T3

M33272.1, M62890.1, U73702.1, AL022576.1, U29376.1, U22025.1 , U22019.1, U22017.1, NM_002020.1, AF144731.1, AF177536.1, AC007122.1, AC006276.1, AF000299.1, L41927.1, AC003971.1, AL031736.16, AL163214.2, Z74581.1, U43143.1, Z71646.1 , M83665.1, AB004535.1, AP001669.1 , Z17240.1, X62534.1, X69878.1 , X68203.1, M15825.1, D78303.1, AC012000.3, AC005970.2, AC006943.25, AE003681.1, AE003513.1, AE003508.1, AC005743.5, NM_002233.1 , AC0O4887.2, AC007529.5, AL161590.2, Z66525.1, U62741.1, AL136538.1, Z82178.2, AL035412.22, U31328.1, M60450.1, D87445.2, M80206.1, L13404.1, M61185.1, L15313.1, X89626.1, AW415958.1, AA312591.1, AW748894.1, AW748893.1, AW748903.1, AI098848.1, AA084882.1, AU080777.1, AI585542.1, AA007643.1, AA546260.1, A1505847.1, AW106399.1, AW456026.1, AA263149.1, AI384994.1, AI588808.1, AA981002.1, AW879508.1, AW866948.1, AW837857.1, AW803636.1 , AW802295.1, AW799320.1, AW799305.1, AW799215.1, AW795369.1 , AW795295.1 , AW795283.1 , AW795203.1 , AW673780.1 , AW608831.1, AW605184.1 , AW605160.1 , AW605135.1, AW571487.1, AW468394.1, AW440973.1, AW291824.1, AW204191.1, AW327783.1, AW327724.1, AWl 67852.1 , AI954999.1, AI954175.1, AI905275.1, AI831782.1, AV159089.1, AI745038.1, AI683060.1, AA818062.1 , AI380618.1, AI3731 15.1 , AI355746.1, AI338618.1, AI336359.1, AI133236.1, AI126474.1 , AI022067.1, AA822594.1, AA580516.1, AA426205.1, AAl 72425.1 , AAl 27538.1, C02000.1, W60824.1, T52063.1, AW754153.1, AW703947.1, AW568633.1, AW568193.1, AW543555.1 , AWl 74306.1, AI987993.1, AI942415.1, AI914296.1, AV197798.1, AV197063.1, AV195631.1 , AV187218.1, AI856536.1, AI856317.1, AI546306.1, AI441075.1 , AI337102.1, AI082230.1, AU023412.1, AA684640.1, AL139095.5, AL138878.4, AC024364.3, AC063933.3, AC053521.3, AC025925.2, AC021 185.2, AC023350.1, AC012452.3, AC010893.4, AL109933.21, AC026790.2, AC025399.2, AC034197.2, AC021814.2, AC026219.1, AC016723.4, AC007218.2, AC024911.1, AC018551.1, AC008026.3, AC010184.9, AC026034.3, AC022095.4, ACOl 1544.5, AC025700.3, AC013364.7, AC025494.2, AC018740.2, AC023364.3, AC022270.3, AC010892.3, AC009588.4, AF130418.2, AC006916.1, AL354926.1, AP001560.1 , AC009543.4, AC058333.2, AC068808.4, AC016634.4, AC026982.2, AC036147.1, AC023639.2, AC023549.2, AC015844.4, AC010708.9, AC016710.3, AC017792.1

SEQ ID NO: 579 ZH1219/T7

AC012599.8, NM_003831.1, AF013591.1, AC004092.1, L78822.1 , L04666.1, NC .001146.1, NM_005711.1, ACOl 1604.10, AC006582.13, AC005919.1, AC005788.1 , U70312.1, AF0O353O.1 , AL133247.1, AL133249.1, X74595.1, Z71448.1, M24109.1, L20973.1 , LI 9930.1, AI686567.1, AW073551.1, AA007617.1, AA702832.1, AA778768.1 , AA127539.1, AA085379.1, F31106.1 , AW196506.1. F36537.1, AW137246.1, All 18179.1, AW268860.1, AW582844.1, AI702678.1, AA127538.1 , AI651413.1, AW324433.1, AA073164.1, AI465698.1, AW390105.1, AI616122.1, AA693126.1 , AA007643.1, AA577233.1, AA648320.1, AA856137.1, AI904448.1, AA072738.1, AI990395.1, AU024036.1, AI904456.1, AV359288.1, AV318953.1, AI561593.1, AI420526.1, AA153299.1 , AI221321.1, AV292110.1, AA689696.1, AW358951.1, AW215056.1, AW632839.1 , AV258581.1 , AW431906.1, AV359373.1, AV278180.1, AW006290.1, AI743057.1 , AA346970.1, W47066.1, T54240.1 , AV374296.1, AV155600.1 , W78921.1, H70287.1, AL138878.4, AL139095.5, AC005842.6, AC068656.1 , AC025763.2, AC024410.2, AC053543.3, AC008502.4, AC024218.2, AC026634.2, AC025550.3, ACOl 1818.3, AP001969.1, AC025018.3, AC009292.7, AC055730.3, AC009362.6, AC012028.8, AC007351.16, AC055710.3, AC025577.10, AC024219.7, AC024146.5, AC022265.2, AC064829.3, AC051645.2, AC016639.5, AC008422.4, AC016632.4, AC008914.3, AC026147.3, AC025019.2, AC024164.2, AC019173.3, AC023194.3, AC034249.1, ACOl 1791.3, AC024423.2, AC016441.4, AC022551.3, AC024469.1, AC016991.2, AL356321.1, AL049185.4

SEQ ID NO: 580

ZH1224/T3

AC004518.1, AL031515.1, Z78020.1, AC007167.4, AE003664.1, AC010721.2, AC005719.1, AC006312.8, AC005071.2, Z82098.1, L06475.1 , ALl 63250.2, Y13223.1, D90904.1, AP001705.1, AP000200.1, M96375.1, AB035643.1,

AB025626.1, AP000240.1, AP000096.1, L08619.1, AW796193.1, AA452059.1, AW462979.1, AA286392.1, AW196278.1, AW344995.1, H45835.1, AA717913.1, AA914833.1, AA471817.1, H67409.1, AI738533.1 , AW345664.1 , AW669099.I, H40960.1, AI949918.1, AW417083.1, AW659395.1, AW657341.1, AW659396.1, AW082239.1 , H33115.1, AA371825.1, AW428094.1, C03101.1, AW347849.1, AA474957.1, AW652791.1, AW447687.1, AA498325.1, W52611.1, AA473787.1, AI183911.1, W45886.1, AI394287.1, AW003201.1, AI825852.1, AW742208.1, AI654179.1, AI952990.1, AI288463.1, AI871094.1, AI224107.1, Z43714.1, AI379594.1, AI631747.1 , AW149713.1, AI697568.1, AW446195.1, AI376007.1, AA679218.1, AA291230.1, AA604759.1, AA934029.1, R61777.1, AI231325.1, AI175584.1 , AI278200.1, AW301292.1, R25280.1, AI982025.1, AI271450.1, AI494419.1, AA505600.1, AW635592.1, AW679028.1, AW659882.1, AW220970.1, AW220925.1, AI468663.1, AW916147.1, AW697381.1, AV288995.1, AT001952.1, AVI 18816.1, AV010877.1, AA957338.1, AI324005.1, AI232228.1, AA565704.1, AA527434.1, AA077196.1, ACO 12435.6, AC068707.2, AC067397.1, AC045240.1, AC035275.1, AL031847.10, AL035406.22, AC026255.2, AC009788.3, AC044902.2, ACOl 1446.4, AC008805.6, AC068093.1, AC018539.4, AC005073.2, AC026658.2, AC022270.3, ACOl 1912.3, AC021669.I , AC021335.1, AC016451.1, AC009581.3, ACO 14977.1, AL353694.6, AL162231.4, AL136380.2, AL136316.3, AL355991.1, AL133490.1, AP000583.2, AP000724.1, AP000721.1

SEQ ID NO: 581

ZH1224/T7

AL355112.1, NC .001148.1, AC005395.2, X94561.1, Z73587.1, X76890.1, J03936.1, NM_004656.1, NM_009088.1 ,

AC006208.3, AF045581.1, AF000938.1, AL049759.10, AL135858.2, AL049569.13, L78065.1, Z78020.1, AK000390.1, AK000131.1, AP000359.1, D87462.1, AC006954.7, AE003825.1, AE003664.1, NM_004913.1, NM_007738.1, NM_008709.1, AC005377.2, AF193139.1, AC005719.1, AC006499.13, AF123462.1, AC005753.1, AC004582.1, AC005175.1, U32177.1, U32107.1, Z82098.1, L06475.1, AL163302.2, AL163250.2, S63654.1, Z54334.1, Y17736.2, X03919.1, D90904.1, AP001705.1, AP000200.1, AB035643.1, AB025626.1, AP000240.1, M36277.1, M12731.1, AP000096.1, AB018551.1, L08619.1 , AW082239.1, AI654179.1, AW003201.1, AI825852.1, AI952990.1, AI871094.1 , AI224107.1, AI379594.1, AI697568.1, AI376007.1, AW149713.1, AI271450.1, AI494419.1, AI631747.1, AI126044.1, AI982796.1, AA505600.1, AA809294.1, AA679218.1, AI769969.1, AI922055.1, AI888073.1, AI660779.1, AI573232.1, AI672728.1, AI424355.1, AA934029.1, AW594391.I , AI097331.1, AW172683.1, AI468663.1, AI372977.1 , AI560425.1, AA604759.1, H45804.1, Z39771.1, AI399773.1, AI288463.1, AI278200.1, AI280353.1, AW301292.1, AI670035.1, H40917.1, AA929008.1, AI695083.1, AI245229.1, AW796193.1, AI887984.1, AI399662.1, AI351359.1, AA905734.1, H67361.1, R61778.1, AA557859.1, AI886596.1, H67409.1, AW602721.1 , AI738533.1 , AI949918.1, AA808459.1, AA824550.1, AI394287.1, F32972.1, AA451862.1, AI042094.1, T03324.1, H40960.1, AF007771.1, AI175584.1, AI18391 1.1, AW652791.1 , AI231325.1, AW446195.1, AA284151.1 , H45835.1 , AU059969.1 , AI576005.1, F02428.1, R46631.1, AA498325.1, AIOl 1048.1, AA473787.1, AI674506.1, AW345664.1, AI025594.1, AA782656.1, AI853068.1, AI235894.1, AW527260.1, H331 14.1 , AW196278.1, AI854488.1, N47450.1, AA371825.1, AI714003.1, AI713835.1, AI155319.1, AW344995.1, AA452059.1, AA186101.1, AC012435.6, AL352984.1, AC027735.3, AC023973.3,

AC008083.i l, AC024148.8, AC006431.8, AC022070.12, AC034186.2, AC026161.2, AC024042.3, AC021108.3, AC015875.1, AL157900.4, AL157397.2, AC068818.1, AC010484.3, AC008439.3, AC010538.4, AC060799.2, AC037446.1, AC016446.5, AC0I 8529.4, AC024520.1, ACO 16978.2, AC012304.2, AC019318.2, AC020320.1, AC009528.7, AC015451.1, AC014977.1, AC007473.9, AL355594.4, AL353572.2, AL136309.4, AL121899.17, AJ239326.3. AP001810.1

SEQ ID NO: 582 ZH1356/T3 AK000577.1, NM_016223.1 , AF130979.1, NM_011861.1, X85124.1, AF188630.1, NM_011862.1, AF128535.1, AB037800.1, AE003840.1, AF139495.1, AF139494.1, AF139493.1, AF 139492.1 , NM_007229.1, AF128536.1 , AF104402.1, AL022476.2, AC007680.2, AF030876.1, AC004561.2, AC012467.9, AE003731.1 , AE003480.1, L27063.1, AF031075.1 , AF094828.1, AC007021.3, AF055895.1, U521 12.1 , X99335.1, AL009204.1, AB041584.1, D14068.1, AB020878.1, AW328241.1, AI415693.1, AI427270.1, W46097.1, AA171908.1, AW908012.1, W24724.1, AA499441.1, AA289880.1, AA793579.1, W44248.1, W24725.1, AW408380.1, AW641932.1, ALl 19244.1 , AW762532.1, AW471083.1, AW255104.1, AI627848.1, AI275465.1, H81644.1, AI275938.1 , AW492862.1, AW098801.1, AW086524.1, AI881986.1, AI645579.1, AA994288.1, AA902835.1, AA844675.1, AA757670.1, AA620827.1, AA518826.1, AA140167.1, W57231.1, AC024045.3, AL157372.6, AC025634.1, AC014463.1, Z82199.1, AC012469.6, AL158217.3, AC013307.5, AC034099.2, AC012515.11, AC012264.8, ACOl 1938.3, AC010787.3, AC022488.2, AC023204.1, AC007771.6, AC010988.3, AC013305.4, AC017943.1, AC015396.1, AL138894.3, AL353773.1, AL353141.1, AP001459.1, AP000803.1

SEQ ID NO: 583

ZH1356/T7

NM_016223.1, AF 130979.1 , AK000577.1, AB037800.1, NM H4063.1, ACOl 1599.8, AF197060.1, AF196968.1, NM_010840.1, AF 105994.1, Z82244.1, AF030227.1, AC010386.5, AE003810.1, AF239824.1, AC005775.1,

NM_005428.2, NM_011862.1, NM_005957.1, U09806.2, AF105983.1, AC008151.I , AC007649.12, AC008369.1, AF 128535.1 , AC006057.5, ALl 63302.2, AL109938.8, Z93096.1 , U30327.1 , AJ237672.1 , X 16316.1 , X92487.1 , AK001717.1, AK000868.1, AP000501.1, AP000350.1, AW193981.1, AA576536.1, AW439879.1, AA587394.1 , AI075695.1 , AI735027.1 , AA218860.1 , AI749755.1 , AW206358.1 , AA452508.1 , AI073515.1, AW328242.1 , F25077.1 , AI283940.1, AI828816.1, AI741698.1, AA454093.1, AI280249.1, AI826261.1 , F26225.1, AI567379.1, AA171893.1, AA350150.1, AI354257.1, AI251129.1, AW129660.1, AI357160.1, H24638.1, F36700.I , F26293.1, AI270014.1, AI952189.1 , AA834233.1 , AI689497.1 , AI688448.1 , AW362737.1 , N93072.1 , F 17480.2, AW431729.1 , AW413130.1 , Z38509.1, AI594932.1, AW251630.1, AA016415.1, AA015524.1, AA940399.1, N93071.1, AI839841.1, AW273866.1, AI480991.1, AA924922.1, AI706853.1, AA103104.1, AW357203.1, AW184060.1, AW048905.1 , A1706877.1, AA061854.1, AW522470.1, AI619781.1, AI579120.1, AIOl 7889.1, AA324499.1, H22790.1, AW385462.1, AW404930.1, AW252629.1, AW247807.1, AAl 93529.1, AW804483.1, AW575217.1, AW495689.1, AW347757.1, AI886795.1, AI886722.1, AI491469.2, AA898753.1, AA628345.I, AA084232.1, R82530.1, AC024045.3, AC027737.3, AL157372.6, AC048379.2, AC004580.2, AC004579.1, AC004394.1, AC069271.2, AC026441.2, AC020982.3, AC016648.4, AC026218.2, AC018505.3, AC018843.2, AC018831.3, AC022377.1, AC012550.1, AL161448.3, AC027052.3, AC007569.8, AC012246.3, AL354832.2, AC025996.4, AC041022.3, AC068282.3, AC020922.5, AC010976.4, AC026386.4, AG053497.2, AC021384.3, AC019103.4, AC023063.7, AC022892.1, AC017160.1, AC013313.1, AC010878.1, AC007791.13, AC008095.2, AL121777.17, AL139327.13, AL356356.1, AL035456.24, AL354944.2, AL355360.2, AL161652.5, Z95330.10 SEQ ID NO: 584 ZH1375 T3

AC068499.1 , Z92780.1 , AJ251880.1 , AF239701.1, AC006795.2, AE002918.1 , AE002665.1 , AC009311.2, AC005066.1 , AC012561.2, X79076.1, AL022721.1, AL356173.1, AL163220.2, X83524.1, AP001675.1, AP000958.2, ABOl 1479.1, M28161.1, AA428948.1, AI879131.1, R15907.1 , AA040001.1, AI967928.1, AW071642.1, Z43817.1, AI149361.1, AW785553.1, AA448896.1, AI436690.1, AI831898.1, AI800263.1, AI262999.1, AI984945.1 , AA655517.1, AI344209.1, AW326298.1, AW355025.1, AA717582.1 , AW446558.1, AW408623.1, AI026945.1, AI535381.1, AW837103.1, AW352814.1, AI202924.1, AI156144.1, AW647549.1, AW404545.1, AW246104.1 , W60604.1, X94529.1, AI624509.1, AW912173.1, BB001328.1, AW767552.1, AW680443.1, AV351077.1, AW158556.1, AV218637.1, AW060414.1, AV148236.1, AI527650.1, AI353655.1 , AA764432.1, C77297.1, AA434896.1, AA414285.1, AA137699.1 , AA069209.1, AC019054.3, AC012103.2, AC040963.2, AC032024.3, AC012220.5, AC0081 18.12, AC007553.11, AC009762.4, AC018531.4, AC016896.3, AP001264.1, AC018412.3, AC025749.2, AL355522.2, AC007622.17, AC024225.8, AC024224.6, AC022507.12, AC032002.2, AC022547.3, AC018731.4, AC027469.2, AC023837.8, AC044890.1, AC0I2421.6, AC025384.2, AC009554.4, AC024713.2, AC024417.2, AC013777.3 SEQ ID NO: 585 ZH1375/T7

Z99281.1 , U95974.1, AC005702.1, AL161533.2, AL078606.1, AB010074.1, AF145751.1, AE003429.1, AL021978.1, Z83237.1, AC001226.1, AL050391.1, AL022100.13, Z82185.1, Z68871.1, Z97200.1 , AL035209.1, AB005229.1, D88363.1, AA040001.1, AI026945.1, Z43817.1 , AW404545.1 , N59030.1, AA024476.1, AI879131.1, AA028041.1, AW326298.1 , AA428948.1, AA655517.1, AW071642.1, AI967928.1 , AI831898.1, AI262999.1, AI149361.1, AI535381.1, AW837103.1, AW575737.1, AW785553.1, AW352814.1, AA717582.1, AI156144.1 , R15907.1, AI202924.1, AI605706.1, AA589995.1, AA546348.1, AA210197.1, AW123704.1, AA455901.1 , AA415948.1, AW355025.1, AW610618.1, X94529.1, AI984945.1, AI800263.1, AI436690.1, AI344209.1, AI007144.1 , AI007142.1, AI124576.1, W26293.1, AW680443.1, AW446558.1, W12131.1, AV373768.1, AV369884.1, AV351169.1, AI908470.1, AI822397.1 , AA888988.1, AA3421 15.1, AC019054.3, AC021615.4, AC018614.3, Z92841.1, AC012220.5, AC009762.4, AL138900.4, AC025048.3, AC068211.1, AC023352.3, AC010096.4, AC010803.2, AL355674.2, AC009774.4, AC012027.10, AC068300.4, AC025033.5, AC020979.2, AC016553.4, AC010295.4, AC010523.4, AC024679.2, AC013447.3, AC062005.1 , AC034172.2, AC041026.1 , AC025601.2, ACOl 1043.3, AC016800.2, ACOl 1841.3, AC023418.1, AC007502.2, AC007500.2, AC020785.2, AC022385.1, AC023714.2, AC012357.3, AC010885.3, AC010936.2, AC013211.1, AL138795.3, AL109942.8, AL157767.5, AL162399.3, AL008882.1, AP002004.1, Z98869.1

SEQ ID NO: 586 ZH1393/T3 AE003550.1 , AC009476.3, NM_012382.1 , AC004822.1, AF023244.1 , U39726.1 , U39731.1, AB015506.1, AB015503.1, AP000079.1, AP000419.1 , AE001697.1, Z72502.1, AJ237785.1, AJ390496.1 , AJ007794.1 , X54057.1, AP001306.1, AP000382.1, AC007682.2, M63080.1, AW372449.1, AI391312.1, W18534.1, AU035125.1, AWl 58249.1 , AI599734.1, AA963894.1, AA963691.1 , AI408537.1 , AA901042.I , AI043558.1, AA917049.1, AA851615.1, AA550464.1, AW919867.1, AW864050.1, AW351172.1, AW347411.1, AW238579.1, AV255372.1, AWl 11079.1, AWl 11078.1, AW011763.1, AV146281.1, AI721947.1, AV030796.1, AI648977.1, AI574183.1, AI509914.1, AI465745.1, AI240036.1, AH78270.1, AI080964.1 , AI041718.1 , AA929446.1, AA869764.1 , AA839185.1, AA690360.1, AA619492.1, AA162490.1, AAl 18105.1, N21983.1, H02265.1, AC021473.3, AC016310.5, AC067925.1 , AC015700.4, AC018955.2, AC019351.3, ACOl 1291.4, AC025702.3, AC010560.5, AC020323.1, AL138928.2, AC068844.1, AC023271.3, AC021401.4, AC019045.4, AC026906.2, AC026493.3, AC018881.4, AC016710.3, AC024019.3, AC024215.7, AC027793.2, AC032015.2, AC026462.1, ACOl 1840.3, AC015574.4, AC010703.2, AC013774.2, AL133211.3, AL138782.5, ALl 33462.13

SEQ ID NO: 587 ZH1393/T7 AL031599.1, AF080118.1, AL161518.2, AL049525.1, AL008627.1, AC020633.3, AE003780.1, AE003591.1,

AC007676.19, U07083.1, AL163290.2, Z98885.1, AP001745.1, AP001619.1 , D64003.1, X74961.1, AB006697.1, AC007869.2, AC004553.1, AC004544.1, Z68752.1, M16110.1, AL136132.15, AL132987.2, ALl 17325.3, U21916.1, U41007.1, M38272.1, AI885274.1 , AW486134.1, AI283076.1, AI266380.1, R96130.1, AW024037.1, AA025609.1, AA972439.1, AW061311.1, R96089.1, AV345769.1, AI414381.1, AI671785.1 , AW372449.1, AI490448.1, AI485909.1, AU081238.1, AU075592.1, AU029967.1 , AW532756.1, AJ399099.1, AJ393365.1, AW614987.1, AW477467.1,

AW442849.1, AW294222.1, AW039440.1, AL036419.1, AI485533.1, H29685.1 , AC021473.3, AC016310.5, AC010736.4, AC022932.2, AL355346.4, APOO 1591.1 , AC024109.9, AC021631.4, AC026702.3, AC0083874, AC008571.3, AC008478.5, AC027463.2, AC009841.6, AC020114.1, AC012727.1, AL353798.5, AC069290.1, AC055821.2, AC008495.4, AC060800.1, AC024658.3, AC019044.2, AC018381.1, AL139152.2, AL158036.3, AL355505.2, Z99776.1, AL021150.1

SEQ ID NO: 588

ZH 172/T3

ALl 37730.1 , AK000015.1 , AC009046.4, ACOl 1745.3, AL161541.2, Z97338.2, U53729.1, ALl 14938.1, AC004669.2, AE003635.1, AC007321.2, AC005711.1, AC005922.1, AF068624.1, AL020991.1 , Z82086.1, AL160236.2, AL132766.13, AL023694.1, Z83821.1, Z48432.1, Z74065.1, M12624.1, Z94847.1, AC007391.3, AF001549.1, AC004253.1 , U67496.1, ALl 61584.2, AL031032.1 , ALl 09838.11 , AL096862.18, U39652.1 , T78076.1 , AI367972.1 , AA815204.1 , N52394.1 , AW607992.1, T86971.1, AW303429.1, AW196107.1, H87717.1, AI703119.1 , AV145264.1, AA872637.1, AI350255.1, AW371247.1, AW414549.1 , AA932625.1, AW143059.1, AA679262.1, AI803182.1, AU034554.1, N76675.1, AW812434.1, AW799395.1, AW799392.1, AW799279.1, AW799276.1 , AW730023.1, AJ397496.1, AV251422.1,

AW141778.1, AI862716.1, AV0231 U .1, AI137198.1, AA765214.1, C62559.1, AA094474.1 , AA068788.1 , N88898.1, H57885.1 , AL353664.3, AC026292.2, AC023120.3, ACOl 1672.3, ACOl 1675.2, AC016390.3, AL354661.2, AC068286.2, AC069133.1, AC025734.2, AC007923.2, AC019342.4, AC022030.1, AC012197.2, AC006779.3, AL157765.2, AL356385.1, ALl 17380.27, AL050349.25, AL162872.1, AL049185.4

SEQ ID NO: 589

ZH 172/17

AL137730.1, AC005166.1 , AK000015.1, AE003829.1, M88598.1, AI631928.1, AI632212.1, AA679262.1, AI379984.1 ,

AI699932.1, AA599222.1 , AI418143.1, N89840.1, AW414549.1, AW 149244.1 , AI289633.1, H09271.1, AW242064.1, AI590137.1, AI174360.1, AA937186.1, AA648294.1, H16062.1, N57911.1, H93047.1 , H00210.1, R64228.1, F03754.1, R82998.1, AW476207.1, AI301228.1, R561 17.1, AA186021.1, T23805.1, AI298048.1, R58994.1 , T15413.1, AI608031.1, R96918.1 , AI539849.1 , AA709322.1 , AA047078.1, AI661161.1, AA289460.1, AW143059.1, AI010543.1, AI362025.1 , AI170628.1, R82955.1, AV134041.1, AI981623.1, AI010920.1, AA260878.1, AL356363.1, AC013599.5, AC026662.2, AC025933.2, AC035142.2, AC018754.3, AC007398.5, AC007352.8, AC017698.1 , AL157763.2

SEQ ID NO: 590

ZH184/T3

AL049911.2, AL163203.2, AL050302.2, AP000542.1, AL163202.2, AP001464.1, AP000026.1, AP000025.1,

NM_014915.1 , AKOOl 137.1, AB028997.1, AE003447.1, AJ223186.1, AC015600.6, AE003494.1 , AC004739.1 , AC006355.3, AC006045.2, U48386.1 , AF044083.1, AL161578.2, AL021633.2, Z70270.1, AL080283.1, AL163233.2, AL163224.2, Z74696.1, U41993.1, D82813.1, AP001679.1, AP001688.1, AP001506.1, AP000961.2, AC005522.2, AC008929.3, AC007379.2, AE003664.1 , AE003509.1, AC012654.2, AC004079.1 , AC006478.2, AC004996.1 , AC005100.2, AC007100.3, AC005879.3, AC007617.10, AC007437.16, AC005331.1 , AC004045.1, Y18930.1, Z991 16.1 , X95911.1, ALl 17195.1, X63956.1, AL032637.1, AL109925.11, AL133465.30, AL132639.2, AL132766.13, AL109985.2, AL078644.10, AL050322.10, AL022395.2, Z82193.1, Y15880.1, L09228.1, M84227.1, AI951118.1, AW373574.1, AA579752.1 , AI989660.1, AI825717.1, AW000914.1 , AI922499.1, AI871874.1, AA991162.1, AV127940.1, AA736439.1, C60377.1, AA219203.1, AA095151.1, AW578955.1, AW418577.1, AW363481.1, AW403036.1, AW262107.1, AV346364.1, AV322534.1, AV282871.1, AI935447.1, AI902224.1, AI754384.I , AV045752.2, AI671778.1, AI591085.1, AI583901.1, AI478844.1, AI360552.1, AI311562.1, Al 168669.1, AH 50310.1, AI086364.1. AA828186.1, AA746252.1 , AA724030.1 , AA701829.1 , AA280548.1, AA151455.1, W16804.1 , N72190.1, AC067744.2, AC036170.2, AL157387.2, AC024252.3, AL353626.1, AL162272.4, AP000776.1, AC017005.4, AC009401.2, ACOl 1254.3, AC012582.3, AC012551.3, AC014239.1, AC062004.2, AC068739.2, AC036209.2, AC007131.3, AC061987.1, AC027699.1, AC012542.4, AC012248.2, AC013152.1, APOOl 133.1, AL022284.1

SEQ ID NO: 591

ZH184/T7

AL109985.2, AL031662.25, AL163282.2, AC006323.3, AC003684.1, ACOl 1310.3, AF217796.1, AC002564.1,

AC004130.1, AC004990.1, AC008062.2, AC004987.2, AC006213.1, AF001549.1, AC004638.1 , AC004087.1, AF042090.1, AL049709.15, AL031542.1, AL157756.2, ALl 33399.1 , AL031224.1, AC004263.1, AC004019.20, AC000052.16, AC004417.1, AC010170.3, AC007957.35, AC025588.1, AC007899.3, AC004854.2, AC004875.1, AC006006.2, AC005412.5, AC007191.1, AC002402.1, AL023494.12, AL137039.1, AL021808.1, AL163262.2, AL121601.13, AL035697.19, AL008582.11, AL035458.35, Z93930.10, AP001717.1 , AP001410.1, AP000190.1, AP000159.1, AP000047.1, AP000046.1, AP000302.1, AP000557.2, D87009.1, AP000556.2, APOOOl 14.1, AC004890.2, AC002310.1, AC005523.1, AF088219.1 , AL031589.10, Z93023.1, AC008039.1, AC010722.2, AC025436.2, AC009087.4, AC009079.4, AF168787.1, AC006111.2, AC006012.2, AF039907.1, AC006312.8, AC005901.1, AC005772.1, AC005754.1, AC005755.1, AC004496.1, Z93241.11, AL163223.2, U62293.1, AL031178.1, AP001678.1 , AP001256.2, AB023049.1 , AP000555.1, AC005072.2, AF006752.1 , AF207550.1, AL163230.2, AL121653.2, AP001685.1, AC000004.1, AC007030.3, AC004821.2, AC006125.1, AL035695.17, AJ239318.3, AP000432.4, AC005565.1, AC0021 15.1, AA553710.1, R72458.1, AI471543.1, F36273.1, AI284640.1, AI610159.1, AW193265.1, AI471481.1, AI334443.1,

AI053672.1 , AA542991.1, AW673241.1, AA825357.1 , AA810370.1 , AA350859.1 , N25296.1 , AW769399.1 , AW511743.1 , AW276827.1, AW193432.1, AW088058.1, AL046409.1, AI688846.1, AI613280.1, AI431303.1, AI350211.1, AI341664.1, AI061334.1, AA179136.1, AI281697.1, AW338086.1, AI358343.1, AA678436.1, AA644538.1, AA521399.1, AA521323.1, T07451.1, AW731867.1, AW166815.1 , AW162049.1, AW029038.1, AI929531.1, AI904894.1, AF150222.1, AI375710.1, AI344844.1, AI340453.1, AI281881.1, AI133164.1 , AA649642.1, AA176924.1, AA134367.1, AA084070.1, AW339568.1, AF150152.1, AI379719.1, AA77181 1.1, AA491814.1, AA156538.1 , AW276817.1, AI339850.1, AA191620.1, AW833903.1 , AW517377.1, AI887483.1, AA664015.1, AA599920.1, AA533725.1, AA483223.1, W79504.1, AW600804.1, AW517721.1, F32808.1, AI567674.1, AI168185.1, AA747472.1, AA719805.1, AA630030.1, AA244357.1, N55273.I, AW303196.1, AW301350.1, AW274349.1, AA581903.1, N71930.1, AW833898.1, AI358571.1, AW265385.1, ALl 19691.1, AI830390.1 , AI298710.1, AA970213.1, AA834713.1, AA280632.1, AA364429.1, T56472.1, AW327868.1, AL042853.2, AI537955.1, AA338522.1, AL157387.2, AC010377.4, AL355887.1, AC022931.3, AL137224.3, AL354864.1, AC021879.3, AC005973.4, ACOl 1484.2, AC026331.3, AC025175.2, AC022668.3, AC027472.3, AC012146.4, AC027393.3, AC023359.7, AC035141.2, AC012042.9, AC021160.3, AC021957.3, AC026397.2, ACOl 1768.4, AC025054.2, AC013648.3, ACOl 1844.3, AC022989.2, AC022845.2, AC017078.3, AC013733.3, AC010165.2, AL049537.36, AL136969.5, AL353715.3, AL159175.4, AL138703.2, AL136223.3, AL157372.6, AP000631.3, AC019222.3, AL354723.1, AC055879.2, AC016555.4, AC009122.5, AC016334.2, AC034119.1, AC007721.15, AL136221.8, AC027096.3, AC021103.6, AC046165.2, AC053540.2, AC010363.5, AC009040.4, AC027709.2, AC009506.3, AC008531.2, AC016700.2, AC011430.4, AC025935.2, AC012141.2, AC012308.4, AC018573.2, AC015758.3, AC022791.1, AC021661.1, AL158830.6, AL354935.3, AC016586.4, AC010649.5, ACOl 1490.4, AC008746.5, AC021634.4, AL355515.2, AC026141.3, AC009417.2, AC005910.5, AC008688.6, AC027550.2, AC068364.1, AC023133.2, AC026300.2, AC018560.3, AC025818.2, AC020780.3, ACOl 1840.3, AC007799.4, AF129075.1, AL161728.2, AL109824.23, AP000931.2, AC064828.3, AL353720.2, AC068889.4, AC021805.3, AC022621.4, AC016688.4, AL162726.3, AC009070.5, AC021474.3, AL121752.8 SEQ ID NO: 592 ZH204/T3

M33272.1, M62890.1, AC003974.2, D86074.1, NM_001231.1, AE003658.1 , NM_007550.1, S73775.1, U85195.1, AE000658.1, U73702.1, U29376.1, AB008674.1, Z98263.1 , NM_000057.1, NC .001147.1, AC005517.6, AC008545.3, AE003701.1, AF214653.1, NM_002095.1, AC002534.1, U71195.1 , AF067418.1, AF005030.1, Z72749.1 , AC000379.1, U83248.1, AL137267.1, S46792.1, S67861.1, AJ006995.1, U22183.1, AJ238237.1, U39817.1, U05314.1, Z73546.1, Z74961.1, Z70678.1, X64324.1, X63469.1, D37935.1, J05080.1, M17028.1, X88900.1 , AJ006966.1, AC013430.4, AF198100.1, AE003626.1, AE003455.I , AL161594.2, AL035679.1, AL035331.1, X90518.1, AL121806.2, AL030978.1, AL353993.1, AL355925.1, AL034558.2, X53233.1, X87371.1, X94607.1, AP000388.1 , AB009050.1, AA312591.1, AW415958.1, AW748894.1, AW748893.1, AW748903.1, AI098848.1, AA007643.1, AU080777.1, AA084882.1, AI585542.1, AA546260.1, AA263149.1, AI505847.1, AWl 06399.1, AA127538.1, AA285232.1, AW456026.1, AI588808.1 , AI384994.1 , AA981002.1 , AW566712.1 , AI787751.1, AW536727.1 , AW413150.1 , AV265194.1 , AV219084.1, AI844907.1, AI842969.1, AVI 60844.1, AV165707.1, AV124038.1, AI779552.1, AV085555.1, AV047038.2, AV046630.2, AI325552.1, AU045190.1, AU018790.1, AU016981.1, AU016595.1, AU016513.1, AU015043.1, AU014858.1, AA252091.1, AA197255.1, AA108210.1, Z74637.1, F01019.1, AW705280.1, AJ281093.1, AW398070.1, AW398039.1, AW397497.1, AW397370.1, AW397141.1, AW397013.1, AW396970.1, AW396868.1, AW395825.1, AW395703.1, AW395679.1, AW395606.1, AW395515.1, AW225544.1, AW186387.1, AI973567.1, AI960869.1, AI941243.1, AI941225.1, AI940836.1, AI883261.1, AL079496.1, AI795023.1, AI759696.1, AI748161.1, AI748087.1, AI736054.1, AI736025.1, AI736012.1, AI406060.1, AI109316.I, AI109205.1, AI063325.1, AA902197.1, AA784297.1, AA553106.1, AA497210.1, AA466795.1, AA462438.1, AA432643.1, AA313904.1, C13433.1, F12959.1, AV185121.1,

C66585.1, AL138878.4, AL139095.5, AC010893.4, AL109933.21, AC025343.2, AC008760.4, AC024364.3, AC063933.3, AC025925.2, AC021185.2, AC023350.1, AC016546.4, AC034197.2, AC021814.2, AC026219.1, AC016723.4, AC007218.2, AC012373.13, AC022890.1, AC017288.1, AC018551.1, AC015313.1, AL139011.6, AP001075.2, AC025685.2, AC061978.2, AC008427.5, AC021869.6, AC027631.2, AC026233.2, AC013364.7, AC013350.6, AC026232.1, ACOl 8740.2, AC023364.3, AC008050.3, AC024301.1, AC010003.5, AC009368.5, AC017158.1, AC008367.3, AC020124.1, AF215848.1, AC008236.3, AC017830.1, AC017944.1, AC012952.1, AL122026.2, AL049185.4, AC068808.4, AC037424.7, AC016634.4, AC008904.3, AC009550.3, AC021972.2, AC020804.2, AC021305.3, AC023103.3, AC020080.1, AC020324.1, AC012195.2, AL138711.3, AL160153.4, AL031745.7 SEQ ID NO: 593 ZH204/T7

AC012599.8, AC004092.1, L78822.1, L04666.1, NC_001146.1, NM_005711.1, AC005919.1, AC005788.1, AC003036.1, U70312.1, AF003530.1, X74595.1, Z71448.1, L20973.1, L19930.1, AI686567.1, AW073551.1, AA007617.1, AA702832.1, AA778768.1, AA127539.1, AA085379.1, F31106.1, AW196506.1, F36537.1, AW137246.1, AW268860.1, AW582844.1, AH 18179.1, AI651413.1, AW324433.1, AI465698.1, AA073164.1, AW390105.1, AA856137.1, AA577233.1,

AA648320.1, AI990395.1, AA072738.1, AI904456.1, AU024036.1, AI702678.1, AA127538.1, AI904448.1, AV359288.I, AI420526.1, AI221321.1, AV292110.1, AI616122.1, AA693126.1, AW215056.1, AV318953.1, AI561593.1, AA153299.1, AA007643.1, AA689696.1, AW431906.1, AV374296.1, AV155600.1, AL138878.4, AL139095.5, AC005842.6, AC024410.2, AC053543.3, AC008502.4, AC024218.2, AC009292.7, AC055730.3, AC009362.6, AC007351.16, AC055710.3, AC025577.10, AC024219.7, AC024146.5, AC022265.2, AC068656.1, AC016639.5, AC008422.4, AC016632.4, AC008914.3, AC025763.2, AC024164.2, AC023194.3, AC034249.1, AC016441.4, AC024469.1, AL049185.4

Table 2; Relation between nucleotide sequences and polypeptide sequences

Example 2: Preparation of recombinant cancer associated antigens

To facilitate screening of patients' sera for antibodies reactive with cancer associated antigens, for example by ELISA, recombinant proteins are prepared according to standard procedures. Where gaps exist in the gene sequences represented by the clones disclosed herein, or where flanking sequences are desired, such nucleic acid sequences can be isolated according to standard procedures. For example, where 5' and 3¹ clones of a gene sequence are known, PCR primers can be designed for amplification of the nucleotide sequence between the clones. Flanking sequences can be isolated using procedures such as RACE PCR. Such sequences also can be isolated by standard hybridization cloning protocols.

In one method of preparing recombinant cancer associated antigens, the clones encoding cancer associated antigens are subcloned into a baculovirus expression vector, and the recombinant expression vectors are introduced into appropriate insect cells. Baculovirus/insect cloning systems are preferred because post-translational modifications are carried out in the insect cells. Another preferred eukaryotic system is the Drosophila Expression System from Invitrogen. Clones which express high amounts of the recombinant protein are selected and used to produce the recombinant proteins. The recombinant proteins are tested for antibody recognition using serum from the patient which was used to isolated the particular clone, or in the case of cancer associated antigens recognized by allogeneic sera, by the sera from any of the patients used to isolate the clones or sera which recognize the clones' gene products.

Alternatively, the cancer associated antigen clones are inserted into a prokaryotic expression vector for production of recombinant proteins in bacteria. Other systems, including yeast expression systems and mammalian cell culture systems also can be used.

Example 3: Preparation of antibodies to cancer associated antigens

The recombinant cancer associated antigens produced as in Example 2 above are used to generate polyclonal antisera and monoclonal antibodies according to standard procedures. The antisera and antibodies so produced are tested for correct recognition of the cancer associated antigens by using the antisera/antibodies in assays of cell extracts of patients known to express the particular cancer associated antigen (e.g. an ELISA assay). These antibodies can be used for experimental purposes (e.g. localization of the cancer associated antigens, immunoprecipitations, Western blots, etc.) as well as diagnostic purposes (e.g., testing extracts of tissue biopsies, testing for the presence of cancer associated antigens).

Example 4: Expression of breast, gastric and prostate cancer associated antigens in cancers of similar and different origin. The expression of one or more of the breast, gastric and/or prostate cancer associated antigens is tested in a range of tumor samples to determine which, if any, other malignancies should be diagnosed and/or treated by the methods described herein. Tumor cell lines and tumor samples are tested for cancer associated antigen expression, preferably by RT-PCR according to standard procedures. Northern blots also are used to test the expression of the cancer associated antigens. Antibody based assays, such as ELISA and western blot, also can be used to determine protein expression. A preferred method of testing expression of cancer associated antigens (in other cancers and in additional same type cancer patients) is allogeneic serotyping using a modified SEREX protocol (as described above).

In all of the foregoing, extracts from the tumors of patients who provided sera for the initial isolation of the cancer associated antigens are used as positive controls. The cells containing recombinant expression vectors described in the Examples above also can be used as positive controls.

The results generated from the foregoing experiments provide panels of multiple cancer associated nucleic acids and/or polypeptides for use in diagnostic (e.g. determining the existence of cancer, determining the prognosis of a patient undergoing therapy, etc.) and therapeutic methods (e.g., vaccine composition, etc.).

Example 5: HLA typing of patients positive for cancer associated antigen

To determine which HLA molecules present peptides derived from the cancer associated antigens, cells of the patients which express the breast and or gastric cancer associated antigens are HLA typed. Peripheral blood lymphocytes are taken from the patient and typed for HLA class I or class π, as well as for the particular subtype of class I or class II. Tumor biopsy samples also can be used for typing. HLA typing can be carried out by any of the standard methods in the art of clinical immunology, such as by recognition by specific monoclonal antibodies, or by HLA allele-specific PCR (e.g. as described in WO97/31126).

Example 6: Characterization of cancer associated antigen peptides presented by MHC class I and class II molecules.

Antigens which provoke an antibody response in a subject may also provoke a cell- mediated immune response. Cells process proteins into peptides for presentation on MHC class I or class II molecules on the cell surface for immune surveillance. Peptides presented by certain MHC/HLA molecules generally conform to motifs. These motifs are known in some cases, and can be used to screen the breast and/or gastric cancer associated antigens for the presence of potential class I and/or class II peptides. Summaries of class I and class II motifs have been published (e.g., Rammensee et al., Immunogenetics 41:178-228, 1995). Based on the results of experiments such as those described above, the HLA types which present the individual breast cancer associated antigens are known. Motifs of peptides presented by these HLA molecules thus are preferentially searched.

One also can search for class I and class II motifs using computer algorithms. For example, computer programs for predicting potential CTL epitopes based on known class I motifs has been described (see, e.g., Parker et al, J. Immunol. 152:163, 1994; D'Amaro et al., Human Immunol 43:13-18, 1995; Drijfhout et al., Human Immunol 43:1-12, 1995). HLA binding predictions can conveniently be made using an algorithm available via the Internet on the National Institutes of Health World Wide Web site at URL http://bimas.dcrt.nih.gov. Methods for determining HLA class II peptides and making substitutions thereto are also known (see, e.g. International applications PCT/US96/03182 and PCT/US98/01373). Computer software for selecting HLA class II binding peptides is also available (TEPITOPE; Sturniolo et al., Nature Biotechnol 17:555-561, 1999; Manici et al., J. Exp. Med. 189:871- 876, 1999). Peptides which are thus selected can be for inducing specific CD4⁺ lymphocytes and identification of peptides. Additional methods of selecting and testing peptides for HLA class II binding are well known in the art.

Example 7: Identification of the portion of a cancer associated polypeptide encoding an antigen

To determine if the cancer associated antigens isolated as described above can provoke a cytolytic T lymphocyte response, the following method is performed. CTL clones are generated by stimulating the peripheral blood lymphocytes (PBLs) of a patient with autologous normal cells transfected with one of the clones encoding a cancer associated antigen polypeptide or with irradiated PBLs loaded with synthetic peptides corresponding to the putative protein and matching the consensus for the appropriate HLA class I molecule (as described above) to localize an antigenic peptide within the cancer associated antigen clone (see, e.g., Knuth et al., Proc. Natl Acad. Sci. USA 81:3511-3515, 1984; van der Bruggen et al., Eur. J. Immunol.24:303S-30 3, 1994). These CTL clones are screened for specificity against COS cells transfected with the cancer associated antigen clone and autologous HLA alleles as described by Brichard et al. (Eur. J. Immunol 26:224-230, 1996). CTL recognition of a cancer associated antigen is determined by measuring release of TNF from the cytolytic T lymphocyte or by ^5ICr release assay (Herin et al., Int. J. Cancer 39:390-396, 1987). If a CTL clone specifically recognizes a transfected COS cell, then shorter fragments of the cancer associated antigen clone transfected in that COS cell are tested to identify the region of the gene that encodes the peptide. Fragments of the cancer associated antigen clone are prepared by exonuclease HI digestion or other standard molecular biology methods. Synthetic peptides are prepared to confirm the exact sequence of the antigen.

Optionally, shorter fragments of cancer associated antigen cDNAs are generated by PCR. Shorter fragments are used to provoke TNF release or ⁵¹Cr release as above.

Synthetic peptides corresponding to portions of the shortest fragment of the cancer associated antigen clone which provokes TNF release are prepared. Progressively shorter peptides are synthesized to determine the optimal cancer associated antigen tumor rejection antigen peptides for a given HLA molecule.

A similar method is performed to determine if the cancer associated antigen contains one or more HLA class II peptides recognized by T cells. One can search the sequence of the cancer associated antigen polypeptides for HLA class II motifs as described above. In contrast to class I peptides, class II peptides are presented by a limited number of cell types. Thus for these experiments, dendritic cells or B cell clones which express HLA class II molecules preferably are used.

Example 8: Recognition of cancer antigens by cancer patient sera

Several of the cancer antigen identified herein were tested for reactivity with sera from normal and breast cancer patients according to standard procedures (e.g., the SEREX procedure outlined above).

Table 3: Serology of antigens

The data show that proteins encoded by SEQ ID NO: 1-12 were recognized by multiple breast cancer patients' sera, but not by control individuals' sera. Proteins encoded by SEQ ID NO:13-18 were recognized by only a single breast cancer patient's sera, but not by control individuals' sera. The

EQUIVALENTS

Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Such equivalents are intended to be encompassed by the following claims.

All references disclosed herein are incorporated by reference in their entirety.

We claim:

Claims

1. A method of diagnosing a disorder characterized by expression of a human cancer associated antigen precursor coded for by a nucleic acid molecule, comprising: contacting a biological sample isolated from a subject with an agent that specifically binds to the nucleic acid molecule, an expression product thereof, or a fragment of an expression product thereof complexed with an HLA molecule, wherein the nucleic acid molecule is a NA Group 1 nucleic acid molecule, and determining the interaction between the agent and the nucleic acid molecule or the expression product as a determination of the disorder.

2. The method of claim 1, wherein the agent is selected from the group consisting of

(a) a nucleic acid molecule comprising NA group 1 nucleic acid molecules or a fragment thereof,

(b) a nucleic acid molecule comprising NA group 3 nucleic acid molecules or a fragment thereof,

(c) a nucleic acid molecule comprising NA group 5 nucleic acid molecules or a fragment thereof,

(d) an antibody that binds to an expression product of NA group 1 nucleic acids,

(e) an antibody that binds to an expression product of NA group 3 nucleic acids, (f) an antibody that binds to an expression product of NA group 5 nucleic acids,

(g) an agent that binds to a complex of an HLA molecule and a fragment of an expression product of a NA group 1 nucleic acid,

(h) an agent that binds to a complex of an HLA molecule and a fragment of an expression product of a NA group 3 nucleic acid, and (i) an agent that binds to a complex of an HLA molecule and a fragment of an expression product of a NA group 5 nucleic acid.

3. The method of claim 1 , wherein the disorder is characterized by expression of a plurality of human cancer associated antigen precursors and wherein the agent is a plurality of agents, each of which is specific for a different human cancer associated antigen precursor, and wherein said plurality of agents is at least 2, at least 3, at least 4, at least 4, at least 6, at least 7, or at least 8, at least 9 or at least 10 such agents.

4. The method of claims 1-3, wherein the agent is specific for a human cancer associated antigen precursor that is a breast cancer associated antigen precursor.

5. A method for determining regression, progression or onset of a condition characterized by expression of abnormal levels of a protein encoded by a nucleic acid molecule that is a NA Group 1 molecule, comprising monitoring a sample, from a patient who has or is suspected of having the condition, for a parameter selected from the group consisting of (i) the protein,

(ii) a peptide derived from the protein,

(iii) an antibody which selectively binds the protein or peptide, and (iv) cytolytic T cells specific for a complex of the peptide derived from the protein and an MHC molecule, as a determination of regression, progression or onset of said condition.

6. The method of claim 5, wherein the sample is a body fluid, a body effusion or a tissue.

7. The method of claim 5, wherein the step of monitoring comprises contacting the sample with a detectable agent selected from the group consisting of

(a) an antibody which selectively binds the protein of (i), or the peptide of (ii),

(b) a protein or peptide which binds the antibody of (iii), and

(c) a cell which presents the complex of the peptide and MHC molecule of (iv).

8. The method of claim 7, wherein the antibody, the protein, the peptide or the cell is labeled with a radioactive label or an enzyme.

9. The method of claim 5, comprising assaying the sample for the peptide.

10. The method of claim 5, wherein the nucleic acid molecule is a NA Group 3 molecule.

11. The method of claim 5, wherein the nucleic acid molecule is a NA Group 5 molecule.

12. The method of claim 5, wherein the protein is a plurality of proteins, the parameter is a plurality of parameters, each of the plurality of parameters being specific for a different one of the plurality of proteins, at least one of which is a cancer associated protein encoded by a NA Group 1 molecule.

13. A pharmaceutical preparation for a human subject comprising an agent which when administered to the subject enriches selectively the presence of complexes of an HLA molecule and a human cancer associated antigen, and a pharmaceutically acceptable carrier, wherein the human cancer associated antigen is a fragment of a human cancer associated antigen precursor encoded by a nucleic acid molecule comprises a NA Group 1 molecule.

14. The pharmaceutical preparation of claim 13, wherein the agent comprises a plurality of agents, each of which enriches selectively in the subject complexes of an HLA molecule and a different human cancer associated antigen, wherein at least one of the human cancer associated antigens is encoded by a NA Group 1 molecule.

15. The pharmaceutical preparation of claim 14, wherein the plurality is at least two, at least three, at least four or at least 5 different such agents.

16. The pharmaceutical preparation of claim 13, wherein the nucleic acid molecule is a NA Group 3 nucleic acid molecule.

17. The pharmaceutical preparation of claim 13, wherein the agent is selected from the group consisting of

(1) an isolated polypeptide comprising the human cancer associated antigen, or a functional variant thereof,

(2) an isolated nucleic acid operably linked to a promoter for expressing the isolated polypeptide, or functional variant thereof,

(3) a host cell expressing the isolated polypeptide, or functional variant thereof, and

(4) isolated complexes of the polypeptide, or functional variants thereof, and an HLA molecule.

18. The pharmaceutical preparation of claims 13-17, further comprising an adjuvant.

19. The pharmaceutical preparation of claim 13, wherein the agent is a cell expressing an isolated polypeptide comprising the human cancer associated antigen or a functional variant thereof, and wherein the cell is nonproliferative.

20. The pharmaceutical preparation of claim 13, wherein the agent is a cell expressing an isolated polypeptide comprising the hiunan cancer associated antigen or a functional variant thereof, and wherein the cell expresses an HLA molecule that binds the polypeptide.

21. The pharmaceutical preparation of claim 13, wherein the agent is at least two, at least three, at least four or at least five different polypeptides, each coding for a different human cancer associated antigen or functional variant thereof, wherein at least one of the human cancer associated antigens is encoded by a NA Group 1 molecule.

22. The pharmaceutical preparation of claim 13, wherein the agent is a PP Group 2 polypeptide.

23. The pharmaceutical preparation of claim 13, wherein the agent is a PP Group 3 polypeptide or a PP Group 4 polypeptide.

24. The pharmaceutical preparation of claim 20, wherein the cell expresses one or both of the polypeptide and HLA molecule recombinantly.

25. The pharmaceutical preparation of claim 20, wherein the cell is nonproliferative.

26. A composition comprising an isolated agent that binds selectively a PP Group 1 polypeptide.

27. The composition of matter of claim 26, wherein the agent binds selectively a PP Group 2 polypeptide.

28. The composition of matter of claim 26, wherein the agent binds selectively a PP Group

3 polypeptide.

29. The composition of matter of claim 26, wherein the agent binds selectively a PP Group

4 polypeptide.

30. The composition of matter of claim 26, wherein the agent binds selectively a PP Group 5 polypeptide.

31. The composition of claims 26-30, wherein the agent is a plurality of different agents that bind selectively at least two, at least three, at least four, or at least five different such polypeptides.

32. The composition of claims 26-30, wherein the agent is an antibody.

33. The composition of claim 31 , wherein the agent is an antibody.

34. A composition of matter comprising a conjugate of the agent of claims 26-30 and a therapeutic or diagnostic agent.

35. A composition of matter comprising a conjugate of the agent of claim 31 and a therapeutic or diagnostic agent.

36. The composition of matter of claim 34, wherein the conjugate is of the agent and a therapeutic or diagnostic that is a toxin.

37. A pharmaceutical composition comprising an isolated nucleic acid molecule selected from the group consisting of NA Group 1 molecules and NA Group 2 molecules, and a pharmaceutically acceptable carrier.

38. The pharmaceutical composition of claim 37, wherein the isolated nucleic acid molecule comprises a NA Group 3 or NA Group 4 molecule.

39. The pharmaceutical composition of claim 37, wherein the isolated nucleic acid molecule comprises at least two isolated nucleic acid molecules coding for two different polypeptides, each polypeptide comprising a different human cancer associated antigen.

40. The pharmaceutical composition of claims 37-39 further comprising an expression vector with a promoter operably linked to the isolated nucleic acid molecule.

41. The pharmaceutical composition of claims 37-39 further comprising a host cell recombinantly expressing the isolated nucleic acid molecule.

42. A pharmaceutical composition comprising an isolated polypeptide comprising a PP Group 1 or a PP Group 2 polypeptide, and a pharmaceutically acceptable carrier.

43. The pharmaceutical composition of claim 42, wherein the isolated polypeptide comprises a PP Group 3 or a PP Group 4 polypeptide.

44. The pharmaceutical composition of claim 42, wherein the isolated polypeptide comprises at least two different polypeptides, each comprising a different human cancer associated antigen.

45. The pharmaceutical composition of claim 42, wherein the isolated polypeptides are breast cancer polypeptides or HLA binding fragments thereof.

46. The pharmaceutical composition of claim 42, wherein the isolated polypeptides are gastric cancer polypeptides or HLA binding fragments thereof.

47. The pharmaceutical composition of claims 42-46, further comprising an adjuvant.

48. An isolated nucleic acid molecule comprising a NA Group 3 molecule.

49. An isolated nucleic acid molecule comprising a NA Group 4 molecule.

50. An isolated nucleic acid molecule selected from the group consisting of

(a) a fragment of a nucleic acid molecule having a nucleotide sequence selected from the group consisting of nucleotide sequences set forth as SEQ ID NOs:l-593, of sufficient length to represent a sequence unique within the human genome, and identifying a nucleic acid encoding a human cancer associated antigen precursor, (b) complements of (a), provided that the fragment includes a sequence of contiguous nucleotides which is not identical to any sequence selected from the sequence group consisting of

(1) sequences having the GenBank accession numbers of Table 1, and other publicly available sequences, (2) complements of ( 1 ), and

(3) fragments of (1) and (2).

51. The isolated nucleic acid molecule of claim 50, wherein the sequence of contiguous nucleotides is selected from the group consisting of: (1) at least two contiguous nucleotides nonidentical to the sequence group,

(2) at least three contiguous nucleotides nonidentical to the sequence group,

(3) at least four contiguous nucleotides nonidentical to the sequence group,

(4) at least five contiguous nucleotides nonidentical to the sequence group,

(5) at least six contiguous nucleotides nonidentical to the sequence group, (6) at least seven contiguous nucleotides nonidentical to the sequence group.

52. The isolated nucleic acid molecule of claim 50, wherein the fragment has a size selected from the group consisting of at least: 8 nucleotides, 10 nucleotides, 12 nucleotides, 14 nucleotides, 16 nucleotides, 18 nucleotides, 20, nucleotides, 22 nucleotides, 24 nucleotides, 26 nucleotides, 28 nucleotides, 30 nucleotides, 50 nucleotides, 75 nucleotides, 100 nucleotides, and 200 nucleotides.

53. The isolated nucleic acid molecule of claim 50, wherein the molecule encodes a polypeptide which, or a fragment of which, binds a human HLA receptor or a human antibody.

54. An expression vector comprising an isolated nucleic acid molecule of any of claims 48-53 operably linked to a promoter.

55. An expression vector comprising a nucleic acid operably linked to a promoter, wherein the nucleic acid is a NA Group 2 molecule.

56. An expression vector comprising a NA Group 1 or Group 2 molecule and a nucleic acid encoding an HLA molecule.

57. A host cell transformed or transfected with an expression vector of claim 54.

58. A host cell transformed or transfected with an expression vector of claims 55 or 56.

59. A host cell transformed or transfected with an expression vector of claim 54 and further comprising a nucleic acid encoding HLA.

60. A host cell transformed or transfected with an expression vector of claim 55 and further comprising a nucleic acid encoding HLA.

61. An isolated polypeptide encoded by the isolated nucleic acid molecule of claim 48 or claim 49.

62. A fragment of the polypeptide of claim 61 which is immunogenic.

63. The fragment of claim 62, wherein the fragment, or a portion of the fragment, binds HLA or a human antibody.

64. An isolated fragment of a human cancer associated antigen precursor which, or portion of which, binds HLA or a human antibody, wherein the precursor is encoded by a nucleic acid molecule that is a NA Group 1 molecule.

65. The fragment of claim 64, wherein the fragment is part of a complex with HLA.

66. The fragment of claim 65, wherein the fragment is between 8 and 12 amino acids in length.

67. An isolated polypeptide comprising a fragment of the polypeptide of claim 61 of sufficient length to represent a sequence unique within the human genome and identifying a polypeptide that is a human cancer associated antigen precursor.

68. A kit for detecting the presence of the expression of a human cancer associated antigen precursor comprising a pair of isolated nucleic acid molecules each of which consists essentially of a molecule selected from the group consisting of (a) a 12-32 nucleotide contiguous segment of the nucleotide sequence of any of the NA Group 1 molecules and (b) complements of (a), wherein the contiguous segments are nonoverlapping.

69. The kit of claim 68, wherein the pair of isolated nucleic acid molecules is constructed and arranged to selectively amplify an isolated nucleic acid molecule that is a NA Group 3 molecule.

70. A method for treating a subject with a disorder characterized by expression of a human cancer associated antigen precursor, comprising administering to the subject an amount of an agent, which enriches selectively in the subject the presence of complexes of an HLA molecule and a human cancer associated antigen, effective to ameliorate the disorder, wherein the human cancer associated antigen is a fragment of a human cancer associated antigen precursor encoded by a nucleic acid molecule selected from the group consisting of

(a) a nucleic acid molecule comprising NA group 1 nucleic acid molecules,

(b) a nucleic acid molecule comprising NA group 3 nucleic acid molecules, (c) a nucleic acid molecule comprising NA group 5 nucleic acid molecules.

71. The method of claim 70, wherein the disorder is characterized by expression of a plurality of human cancer associated antigen precursors and wherein the agent is a plurality of agents, each of which enriches selectively in the subject the presence of complexes of an HLA molecule and a different human cancer associated antigen, wherein at least one of the human cancer associated antigens is encoded by a NA Group 1 molecule.

72. The method of claim 71, wherein the plurality is at least 2, at least 3, at least 4, or at least 5 such agents.

73. The method of claims 70-72, wherein the agent is an isolated polypeptide selected from the group consisting of PP Group 1, PP Group 2, PP Group 3, PP Group 4, and PP Group 5.

74. The method of claims 70-72, wherein the disorder is cancer.

75. The method of claims 73, wherein the disorder is cancer.

76. A method for treating a subject having a condition characterized by expression of a human cancer associated antigen precursor in cells of the subject, comprising:

(i) removing an immunoreactive cell containing sample from the subject, (ii) contacting the immunoreactive cell containing sample to the host cell under conditions favoring production of cytolytic T cells against a human cancer associated antigen which is a fragment of the precursor,

(iii) introducing the cytolytic T cells to the subject in an amount effective to lyse cells which express the human cancer associated antigen, wherein the host cell is transformed or transfected with an expression vector comprising an isolated nucleic acid molecule operably linked to a promoter, the isolated nucleic acid molecule being selected from the group of nucleic acid molecules consisting of NA Group 1, NA Group 2, NA Group 3, NA Group 4, and NA Group 5.

77. The method of claim 76, wherein the host cell recombinantly expresses an HLA molecule which binds the human cancer associated antigen.

78. The method of claim 76, wherein the host cell endogenously expresses an HLA molecule which binds the human cancer associated antigen.

79. A method for treating a subject having a condition characterized by expression of a human cancer associated antigen precursor in cells of the subject, comprising:

(i) identifying a nucleic acid molecule expressed by the cells associated with said condition, wherein said nucleic acid molecule is a NA Group 1 molecule;

(ii) transfecting a host cell with a nucleic acid selected from the group consisting of (a) the nucleic acid molecule identified, (b) a fragment of the nucleic acid identified which includes a segment coding for a human cancer associated antigen, (c) deletions, substitutions or additions to (a) or (b), and (d) degenerates of (a), (b), or (c); (iii) culturing said transfected host cells to express the transfected nucleic acid molecule, and;

(iv) introducing an amount of said host cells or an extract thereof to the subject effective to increase an immune response against the cells of the subject associated with the condition.

80. The method of claim 79, further comprising identifying an MHC molecule which presents a portion of an expression product of the nucleic acid molecule, wherein the host cell expresses the same MHC molecule as identified and wherein the host cell presents an MHC binding portion of the expression product of the nucleic acid molecule.

81. The method of claim 79, wherein the immune response comprises a B-cell response or a T cell response.

82. The method of claim 81 , wherein the response is a T-cell response which comprises generation of cytolytic T-cells specific for the host cells presenting the portion of the expression product of the nucleic acid molecule or cells of the subject expressing the human cancer associated antigen.

83. The method of claim 79, wherein the nucleic acid molecule is a NA Group 3 molecule.

84. The method of claims 79 or 80, further comprising treating the host cells to render them non-proliferative.

85. A method for treating or diagnosing or monitoring a subject having a condition characterized by expression of an abnormal amount of a protein encoded by a nucleic acid molecule that is a NA Group 1 molecule, comprising administering to the subject an antibody which specifically binds to the protein or a peptide derived therefrom, the antibody being coupled to a therapeutically useful agent, in an amount effective to treat the condition.

86. The method of claim 85, wherein the antibody is a monoclonal antibody.

87. The method of claim 86, wherein the monoclonal antibody is a chimeric antibody or a humanized antibody.

88. A method for treating a condition characterized by expression in a subject of abnormal amounts of a protein encoded by a nucleic acid molecule that is a NA Group 1 nucleic acid molecule, comprising administering to a subject a pharmaceutical composition of any one of claims 13-25 and 37-47 in an amount effective to prevent, delay the onset of, or inhibit the condition in the subject.

89. The method of claim 88, wherein the condition is cancer.

90. The method of claim 88, further comprising first identifying that the subject expresses in a tissue abnormal amounts of the protein.

91. The method of claim 89, further comprising first identifying that the subject expresses in a tissue abnormal amounts of the protein.

92. A method for treating a subject having a condition characterized by expression of abnormal amounts of a protein encoded by a nucleic acid molecule that is a NA Group 1 nucleic acid molecule, comprising

(i) identifying cells from the subject which express abnormal amounts of the protein; (ii) isolating a sample of the cells; (iii) cultivating the cells, and

(iv) introducing the cells to the subject in an amount effective to provoke an immune response against the cells.

93. The method of claim 92, further comprising rendering the cells non-proliferative, prior to introducing them to the subject.

94. A method for treating a pathological cell condition characterized by aberrant expression of a protein encoded by a nucleic acid molecule that is a NA Group 1 nucleic acid molecule, comprising administering to a subject in need thereof an effective amount of an agent which inhibits the expression or activity of the protein.

95. The method of claim 94, wherein the agent is an inhibiting antibody which selectively binds to the protein and wherein the antibody is a monoclonal antibody, a chimeric antibody or a humanized antibody.

96. The method of claim 94, wherein the agent is an antisense nucleic acid molecule which selectively binds to the nucleic acid molecule which encodes the protein.

97. The method of claim 94, wherein the nucleic acid molecule is a NA Group 3 nucleic acid molecule.

98. A composition of matter useful in stimulating an immune response to a plurality of a proteins encoded by nucleic acid molecules that are NA Group 1 molecules, comprising a plurality of peptides derived from the amino acid sequences of the proteins, wherein the peptides bind to one or more MHC molecules presented on the surface of the cells which express an abnormal amount of the protein.

99. The composition of matter of claim 98, wherein at least a portion of the plurality of peptides bind to MHC molecules and elicit a cytolytic response thereto.

100. The composition of matter of claim 99, further comprising an adjuvant.

101. The composition of matter of claim 100, wherein said adjuvant is a saponin, GM-CSF, or an interleukin.

102. The composition of matter of claim 98, further comprising at least one peptide useful in stimulating an immune response to at least one protein which is not encoded by nucleic acid molecules that are NA Group 1 molecules, wherein the at least one peptide binds to one or more MHC molecules.

103. An isolated antibody which selectively binds to a complex of:

(i) a peptide derived from a protein encoded by a nucleic acid molecule that is a NA Group 1 molecule and (ii) and an MHC molecule to which binds the peptide to form the complex, wherein the isolated antibody does not bind to (i) or (ii) alone.

104. The antibody of claim 103, wherein the antibody is a monoclonal antibody, a chimeric antibody, a humanized antibody, or a fragment thereof.