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WO2000073328A3 - Unc-5 constructs and screening methods - Google Patents

Unc-5 constructs and screening methods Download PDF

Info

Publication number
WO2000073328A3
WO2000073328A3 PCT/EP2000/005108 EP0005108W WO0073328A3 WO 2000073328 A3 WO2000073328 A3 WO 2000073328A3 EP 0005108 W EP0005108 W EP 0005108W WO 0073328 A3 WO0073328 A3 WO 0073328A3
Authority
WO
WIPO (PCT)
Prior art keywords
unc
constructs
screening methods
protein
cdna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2000/005108
Other languages
French (fr)
Other versions
WO2000073328A2 (en
Inventor
Criekinge Wim Van
Ingele Roelens
Thierry Bogaert
Phillipe Verwaerde
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Devgen NV
Original Assignee
Devgen NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Devgen NV filed Critical Devgen NV
Priority to AU49263/00A priority Critical patent/AU4926300A/en
Publication of WO2000073328A2 publication Critical patent/WO2000073328A2/en
Publication of WO2000073328A3 publication Critical patent/WO2000073328A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides novel splice variants of the human unc-5c cDNA and a novel human unc-5HS1 cDNA sequence. Also provided are assays based on protein-protein interactions between the UNC-5 protein and a variety of different interacting proteins.
PCT/EP2000/005108 1999-06-01 2000-06-02 Unc-5 constructs and screening methods Ceased WO2000073328A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU49263/00A AU4926300A (en) 1999-06-01 2000-06-02 Unc-5 constructs and screening methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9912755.7 1999-06-01
GBGB9912755.7A GB9912755D0 (en) 1999-06-01 1999-06-01 UNC-5 constructs and screening methods

Publications (2)

Publication Number Publication Date
WO2000073328A2 WO2000073328A2 (en) 2000-12-07
WO2000073328A3 true WO2000073328A3 (en) 2001-04-12

Family

ID=10854560

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/005108 Ceased WO2000073328A2 (en) 1999-06-01 2000-06-02 Unc-5 constructs and screening methods

Country Status (3)

Country Link
AU (1) AU4926300A (en)
GB (2) GB9912755D0 (en)
WO (1) WO2000073328A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002010216A2 (en) * 2000-07-28 2002-02-07 Curagen Corporation Proteins and nucleic acids encoding same
EP1356043A2 (en) * 2000-10-04 2003-10-29 Curagen Corporation Novel proteins and nucleic acids encoding same and antibodies directed against these proteins
AU2001293870A1 (en) * 2000-10-16 2002-04-29 Bayer Aktiengesellschaft Regulation of human netrin binding membrane receptor unc5h-1
AU2002363253A1 (en) * 2001-11-01 2003-05-12 Gpc Biotech Inc. Endothelial-cell binding peptides for diagnosis and therapy
EP2267153A1 (en) * 2009-05-26 2010-12-29 Université Claude Bernard Lyon 1 Identification of netrin-1 receptor unc5c gene mutation in solid cancers

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997014424A1 (en) * 1995-10-16 1997-04-24 The Regents Of The University Of California Neurological drug screens
WO1998037085A1 (en) * 1997-02-19 1998-08-27 The Regents Of The University Of California Netrin receptors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997014424A1 (en) * 1995-10-16 1997-04-24 The Regents Of The University Of California Neurological drug screens
WO1998037085A1 (en) * 1997-02-19 1998-08-27 The Regents Of The University Of California Netrin receptors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ACKERMAN SUSAN L ET AL: "Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23.", GENOMICS, vol. 52, no. 2, 1998, pages 205 - 208, XP000946854, ISSN: 0888-7543 *
COLAVITA ANTONIO ET AL: "Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans.", DEVELOPMENTAL BIOLOGY, vol. 194, no. 1, 1 February 1998 (1998-02-01), pages 72 - 85, XP000946782, ISSN: 0012-1606 *

Also Published As

Publication number Publication date
GB2352448B (en) 2002-03-27
GB2352448A (en) 2001-01-31
WO2000073328A2 (en) 2000-12-07
GB0013412D0 (en) 2000-07-26
GB9912755D0 (en) 1999-08-04
AU4926300A (en) 2000-12-18

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