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WO2000071242A1 - Appareil de synthese - Google Patents

Appareil de synthese Download PDF

Info

Publication number
WO2000071242A1
WO2000071242A1 PCT/FI2000/000468 FI0000468W WO0071242A1 WO 2000071242 A1 WO2000071242 A1 WO 2000071242A1 FI 0000468 W FI0000468 W FI 0000468W WO 0071242 A1 WO0071242 A1 WO 0071242A1
Authority
WO
WIPO (PCT)
Prior art keywords
synthesizer
devices
module
synthesizer apparatus
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FI2000/000468
Other languages
English (en)
Inventor
Antti P. Manninen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pam Solutions Ltd Oy
Original Assignee
Pam Solutions Ltd Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pam Solutions Ltd Oy filed Critical Pam Solutions Ltd Oy
Priority to AU47602/00A priority Critical patent/AU4760200A/en
Publication of WO2000071242A1 publication Critical patent/WO2000071242A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/004—Multifunctional apparatus for automatic manufacturing of various chemical products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00018—Construction aspects
    • B01J2219/0002—Plants assembled from modules joined together
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00599—Solution-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00695—Synthesis control routines, e.g. using computer programs
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Definitions

  • the present invention relates to a synthesizer apparatus, and more specifically to a multi-purpose, module-based synthesizer apparatus for performing a variety of chemical syntheses.
  • the present invention is intended to create a solution for carrying out the aforesaid variety of tasks flexibly and in a highly adaptable manner. This is achieved by means of an apparatus, the characteristic features of which are stated in the accompanying Claims.
  • the apparatus automates chemical synthesis.
  • a particular new feature of the apparatus is that the same basic unit can be applied to various chemical syntheses and that individual devices can be linked to form a network of different synthesizers, to accelerate the development of syntheses and processes, and also, if required, to permit the production of larger amounts of substances, by using several devices simultaneously.
  • Figure 1 shows the structure of one synthesizer according to the invention
  • Figure 2 shows an apparatus comprising one synthesizer module and the computer required by it.
  • Figure 3 shows an apparatus entity comprising several synthesizer modules and a control computer.
  • Figure 4 shows an alternative, in which the synthesizers are distributed between several users, with one, two, or three apparatuses for each user.
  • the apparatus includes at least one procedure-specific detachable and exchangeable component, which is called an additional module.
  • the common basic module part contains components performing common functions, such as;
  • - reagent tray from which some of the reagents are taken, in which reagents can be diluted prior to addition, and to which the end products can be transferred, if necessary, - injector units and pumps, for the addition of liquid substances,
  • the reactor and its auxiliary devices are exchangeable and are attached to detachable front panels. Device changes are needed if very different syntheses are carried out.
  • the invention can be applied to many different situations.
  • An apparatus according to the invention can be used, for instance, to form a synthesizer network of individual modules.
  • Effective and versatile research equipment is typically rather difficult to operate and usually requires an operator who is familiar with one or more apparatuses.
  • large apparatuses are almost entirely useless, if some component breaks down or if it takes a long time to service or find a repair technician. Naturally, this reduces both the effective operating time of the apparatus and the results achieved with it.
  • Figure 1 shows one model for a synthesizer module.
  • the fixed part 1 contains electronics 3, operating devices 4, and a reagent tray 5.
  • the exchangeable part 2 contains the reactor 6 itself and its auxiliary devices 7.
  • the present invention also has the advantage that purchasers can first acquire a single device for a relatively small sum of money and check that it operates in practice. This situation is shown in Figure 2, in which there is only a single synthesizer module 8 with its control computer 9. After this, the number of devices required by the research can be safely added, resulting in the network solution according to Figure 3 as described above, if this is necessary.
  • a single synthesizer developing a fault can be detached from the network for servicing, while the others continue to operate as before.
  • a network of devices is very suitable for synthesis development, as the parameters (temperature, speed of addition of substances, mixing speed, etc.) are independent in each device.
  • all the synthesizers in the network can be set to carry out the same synthesis.
  • Another extremely important feature of the invention is that, in a research group, a smaller apparatus entity can be given to an individual researcher, to carry out a sub-project. Similarly, in operator training, a new operator can use a single device, while the other devices are used for active research use.
  • Figure 4 shows clearly the division of an apparatus entity into units with one, two, and three synthesizers.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Manufacturing & Machinery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention concerne un appareil de synthèse comprenant un ordinateur ou analogue (9) pour le contrôle de synthèses chimiques et un réacteur (8) en vue de créer et d'effectuer les réactions chimiques désirées. L'appareil de synthèse (8) comprend une unité ou module de base fixe (1) renfermant des dispositifs (3, 4, 5) destinés à effectuer les opérations fondamentales, et une unité ou module supplémentaire (2) séparé, interchangeable, renfermant des dispositifs (6, 7) destinés à effectuer les opérations dépendant de la réaction particulière à effectuer.
PCT/FI2000/000468 1999-05-24 2000-05-24 Appareil de synthese Ceased WO2000071242A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU47602/00A AU4760200A (en) 1999-05-24 2000-05-24 Synthesizer apparatus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI991175A FI111342B (fi) 1999-05-24 1999-05-24 Syntetisaattorilaitteisto
FI991175 1999-05-24

Publications (1)

Publication Number Publication Date
WO2000071242A1 true WO2000071242A1 (fr) 2000-11-30

Family

ID=8554721

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2000/000468 Ceased WO2000071242A1 (fr) 1999-05-24 2000-05-24 Appareil de synthese

Country Status (3)

Country Link
AU (1) AU4760200A (fr)
FI (1) FI111342B (fr)
WO (1) WO2000071242A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362699A (en) * 1981-03-10 1982-12-07 Bio Research, Inc. Apparatus for high pressure peptide synthesis
US4483964A (en) * 1983-06-20 1984-11-20 Chiron Corporation Reactor system and method for polynucleotide synthesis
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362699A (en) * 1981-03-10 1982-12-07 Bio Research, Inc. Apparatus for high pressure peptide synthesis
US4483964A (en) * 1983-06-20 1984-11-20 Chiron Corporation Reactor system and method for polynucleotide synthesis
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers

Also Published As

Publication number Publication date
FI991175A0 (fi) 1999-05-24
FI111342B (fi) 2003-07-15
FI991175L (fi) 2000-11-25
AU4760200A (en) 2000-12-12

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