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WO2000070096A3 - Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus - Google Patents

Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus Download PDF

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Publication number
WO2000070096A3
WO2000070096A3 PCT/US2000/013655 US0013655W WO0070096A3 WO 2000070096 A3 WO2000070096 A3 WO 2000070096A3 US 0013655 W US0013655 W US 0013655W WO 0070096 A3 WO0070096 A3 WO 0070096A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
bat
locus
mutation
assay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/013655
Other languages
French (fr)
Other versions
WO2000070096A2 (en
Inventor
Steven Laken
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exact Sciences Corp
Original Assignee
Exact Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exact Laboratories Inc filed Critical Exact Laboratories Inc
Priority to CA002372667A priority Critical patent/CA2372667A1/en
Priority to EP00932573A priority patent/EP1179092A2/en
Priority to JP2000618501A priority patent/JP2002543855A/en
Priority to AU50274/00A priority patent/AU767833B2/en
Publication of WO2000070096A2 publication Critical patent/WO2000070096A2/en
Publication of WO2000070096A3 publication Critical patent/WO2000070096A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Methods of the invention comprise assays for markers indicative of cancer, precancer, and other diseases or disorders. Assays of the invention are preformed on heterogeneous samples obtained from patients by non-invasive or minimally-invasive methods. Such assays may be employed alone or in combination with other disease screening techniques.
PCT/US2000/013655 1999-01-10 2000-05-18 Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus Ceased WO2000070096A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002372667A CA2372667A1 (en) 1999-01-10 2000-05-18 Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus
EP00932573A EP1179092A2 (en) 1999-01-10 2000-05-18 Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus
JP2000618501A JP2002543855A (en) 1999-01-10 2000-05-18 Method for detecting colorectal disease by performing an assay for detecting mutations at the BAT-26 locus
AU50274/00A AU767833B2 (en) 1999-01-10 2000-05-18 Methods of detecting colorectal disease

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13471199P 1999-01-10 1999-01-10
US60/134,711 1999-05-18
US46867099A 1999-12-21 1999-12-21
US09/468,670 1999-12-21

Publications (2)

Publication Number Publication Date
WO2000070096A2 WO2000070096A2 (en) 2000-11-23
WO2000070096A3 true WO2000070096A3 (en) 2001-06-14

Family

ID=26832603

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/013655 Ceased WO2000070096A2 (en) 1999-01-10 2000-05-18 Methods of detecting colorectal disease by conduction an assay to detect a mutation in a bat-26 locus

Country Status (5)

Country Link
EP (1) EP1179092A2 (en)
JP (1) JP2002543855A (en)
AU (1) AU767833B2 (en)
CA (1) CA2372667A1 (en)
WO (1) WO2000070096A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
US6964846B1 (en) 1999-04-09 2005-11-15 Exact Sciences Corporation Methods for detecting nucleic acids indicative of cancer
US7368233B2 (en) 1999-12-07 2008-05-06 Exact Sciences Corporation Methods of screening for lung neoplasm based on stool samples containing a nucleic acid marker indicative of a neoplasm
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
US6503718B2 (en) * 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US6280947B1 (en) * 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
US20020004206A1 (en) * 1999-04-09 2002-01-10 Berger Barry M. Methods of screening for disease
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
ATE465272T1 (en) 2001-01-31 2010-05-15 Mayo Foundation DETECTION OF HERPEX SIMPLEX VIRUS
US7691571B2 (en) 2001-01-31 2010-04-06 Mayo Foundation For Medical Education And Research Detection of bordetella
US20030180765A1 (en) * 2002-02-01 2003-09-25 The Johns Hopkins University Digital amplification for detection of mismatch repair deficient tumor cells
US20030215954A1 (en) * 2002-05-17 2003-11-20 Cockerill Franklin R. Nucleic acid recovery reagents and methods
US7074598B2 (en) 2002-09-25 2006-07-11 Mayo Foundation For Medical Education And Research Detection of vancomycin-resistant enterococcus spp.
US7365176B2 (en) 2002-09-26 2008-04-29 Mayo Foundation For Medical Education And Research Detection of Epstein-Barr virus
US7427475B2 (en) 2003-11-18 2008-09-23 Mayo Foundation For Medical Education And Research Detection of group B streptococcus
EP1751306A1 (en) * 2004-04-30 2007-02-14 Yale University Methods and compositions for cancer diagnosis
WO2007044071A2 (en) 2005-04-21 2007-04-19 Exact Sciences Corporation Analysis of heterogeneous nucleic acid samples
BR112015012616A2 (en) * 2012-11-30 2017-09-12 Applied Proteomics Inc method for assessing the presence or risk of colon tumors
JP2018517892A (en) 2015-04-10 2018-07-05 アプライド プロテオミクス，インク． Protein biomarker panel to detect colorectal cancer and advanced adenoma
EP3983431A4 (en) * 2019-06-17 2023-12-13 The Board of Trustees of the Leland Stanford Junior University DIAGNOSIS AND TREATMENTS BASED ON MOLECULAR DIAGNOSTIC CHARACTERIZATION OF COLORECTAL CARCINOMA

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5741650A (en) * 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5741650A (en) * 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANDREAS BRAUN ET AL: "Improved Analysis of Microsaellites Using Mass spectrometry", GENOMICS, vol. 46, 1997, pages 18 - 23, XP002162453 *
GISMONDI VIVIANA ET AL: "Characterization of 19 novel and six recurring APC mutations in Italian adenomatous polyposis patients, using two different mutation detection techniques.", HUMAN MUTATION, vol. 9, no. 4, 1997, pages 370 - 373, XP002162567, ISSN: 1059-7794 *
HOANG JEAN-MARC ET AL: "BAT-26, an indicator of the replication error phenotype in colorectal cancers and cell lines.", CANCER RESEARCH, vol. 57, no. 2, 1997, pages 300 - 303, XP002162454, ISSN: 0008-5472 *
LOTHE RAGNHILD A ET AL: "The APC gene I1307K variant is rare in Norwegian patients with familial and sporadic colorectal or breast cancer.", CANCER RESEARCH, vol. 58, no. 14, 15 July 1998 (1998-07-15), pages 2923 - 2924, XP002162568, ISSN: 0008-5472 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6964846B1 (en) 1999-04-09 2005-11-15 Exact Sciences Corporation Methods for detecting nucleic acids indicative of cancer
US6849403B1 (en) 1999-09-08 2005-02-01 Exact Sciences Corporation Apparatus and method for drug screening
US6919174B1 (en) 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
US7368233B2 (en) 1999-12-07 2008-05-06 Exact Sciences Corporation Methods of screening for lung neoplasm based on stool samples containing a nucleic acid marker indicative of a neoplasm
US7981612B2 (en) 1999-12-07 2011-07-19 Mayo Foundation For Medical Education And Research Methods of screening for supracolonic neoplasms based on stool samples containing a nucleic acid marker indicative of a neoplasm
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence

Also Published As

Publication number Publication date
AU5027400A (en) 2000-12-05
AU767833B2 (en) 2003-11-27
EP1179092A2 (en) 2002-02-13
CA2372667A1 (en) 2000-11-23
JP2002543855A (en) 2002-12-24
WO2000070096A2 (en) 2000-11-23

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