[go: up one dir, main page]

WO2000069896A3 - Interactions moleculaires dans les cellules hematopoietiques - Google Patents

Interactions moleculaires dans les cellules hematopoietiques Download PDF

Info

Publication number
WO2000069896A3
WO2000069896A3 PCT/US2000/013161 US0013161W WO0069896A3 WO 2000069896 A3 WO2000069896 A3 WO 2000069896A3 US 0013161 W US0013161 W US 0013161W WO 0069896 A3 WO0069896 A3 WO 0069896A3
Authority
WO
WIPO (PCT)
Prior art keywords
molecular interactions
haematopoietic cells
cells
reagents
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/013161
Other languages
English (en)
Other versions
WO2000069896A9 (fr
WO2000069896A2 (fr
Inventor
Peter S Lu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arbor Vita Corp
Original Assignee
Arbor Vita Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arbor Vita Corp filed Critical Arbor Vita Corp
Priority to JP2000618312A priority Critical patent/JP2002543825A/ja
Priority to EP00932386A priority patent/EP1178817A2/fr
Priority to AU50112/00A priority patent/AU5011200A/en
Publication of WO2000069896A2 publication Critical patent/WO2000069896A2/fr
Publication of WO2000069896A3 publication Critical patent/WO2000069896A3/fr
Anticipated expiration legal-status Critical
Publication of WO2000069896A9 publication Critical patent/WO2000069896A9/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des réactifs et des procédés permettant d'inhiber ou d'améliorer les interactions de protéines dans les cellules hématopoïétiques et autres cellules intervenant dans la médiation d'une réponse immunitaire. Les réactifs et les procédés considérés sont utiles pour le traitement d'une variété de maladies et d'affections dont la médiation est assurée par des cellules du système immunitaire.
PCT/US2000/013161 1999-05-14 2000-05-12 Interactions moleculaires dans les cellules hematopoietiques Ceased WO2000069896A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2000618312A JP2002543825A (ja) 1999-05-14 2000-05-12 造血細胞内分子相互作用
EP00932386A EP1178817A2 (fr) 1999-05-14 2000-05-12 Interactions moleculaires dans les cellules hematopoietiques
AU50112/00A AU5011200A (en) 1999-05-14 2000-05-12 Molecular interactions in hematopoietic cells

Applications Claiming Priority (26)

Application Number Priority Date Filing Date Title
US13411499P 1999-05-14 1999-05-14
US13411899P 1999-05-14 1999-05-14
US13411799P 1999-05-14 1999-05-14
US60/134,114 1999-05-14
US60/134,117 1999-05-14
US60/134,118 1999-05-14
US16086099P 1999-10-21 1999-10-21
US60/160,860 1999-10-21
US16249899P 1999-10-29 1999-10-29
US60/162,498 1999-10-29
US17045399P 1999-12-13 1999-12-13
US60/170,453 1999-12-13
US17619500P 2000-01-14 2000-01-14
US60/176,195 2000-01-14
US18229600P 2000-02-14 2000-02-14
US60/182,296 2000-02-14
US19646000P 2000-04-11 2000-04-11
US19626700P 2000-04-11 2000-04-11
US19652700P 2000-04-11 2000-04-11
US54727600A 2000-04-11 2000-04-11
US19652800P 2000-04-11 2000-04-11
US60/196,460 2000-04-11
US60/196,267 2000-04-11
US60/196,528 2000-04-11
US09/547,276 2000-04-11
US60/196,527 2000-04-11

Publications (3)

Publication Number Publication Date
WO2000069896A2 WO2000069896A2 (fr) 2000-11-23
WO2000069896A3 true WO2000069896A3 (fr) 2001-07-05
WO2000069896A9 WO2000069896A9 (fr) 2002-10-03

Family

ID=27584529

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2000/013166 Ceased WO2000069897A2 (fr) 1999-05-14 2000-05-12 Interactions moleculaires dans les lymphocytes t
PCT/US2000/013161 Ceased WO2000069896A2 (fr) 1999-05-14 2000-05-12 Interactions moleculaires dans les cellules hematopoietiques

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2000/013166 Ceased WO2000069897A2 (fr) 1999-05-14 2000-05-12 Interactions moleculaires dans les lymphocytes t

Country Status (4)

Country Link
EP (1) EP1178817A2 (fr)
JP (2) JP2002543825A (fr)
ES (1) ES2436624T3 (fr)
WO (2) WO2000069897A2 (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002522029A (ja) 1998-07-27 2002-07-23 ジェネンテック・インコーポレーテッド コートタンパク質の改変によるファージ提示における改良した形質転換効率
US6942981B1 (en) 1999-05-14 2005-09-13 Arbor Vita Corporation Method of determining interactions with PDZ-domain polypeptides
WO2003014303A2 (fr) * 2001-08-03 2003-02-20 Arbor Vita Corporation Interactions moleculaires dans les cellules
US7510824B2 (en) 1999-06-02 2009-03-31 Nono Inc. Method of screening peptides useful in treating traumatic injury to the brain or spinal cord
US7595297B2 (en) * 1999-06-02 2009-09-29 Michael Tymianski Method of reducing injury to mammalian cells
AU2002215354A1 (en) * 2000-10-13 2002-04-22 Arbor Vita Corporation Molecular interactions in hematopoietic cells
AU2002252015A1 (en) * 2001-02-16 2002-09-04 Arbor Vita Corporation Pdz domain interactions and lipid rafts
JPWO2002088175A1 (ja) * 2001-04-24 2004-08-19 大塚製薬株式会社 クローン病抗体結合性ペプチド及びクローン病の検査方法
AU2011211347B2 (en) * 2001-05-07 2015-02-19 Agriculture Victoria Services Pty Ltd Modification of plant and seed development and plant responses to stresses and stimuli (3)
DE10124342A1 (de) * 2001-05-18 2002-11-28 Biotecon Diagnostics Gmbh Verfahren zum Nachweis von Mikroorganismen der Spezies Yersinia pestis/Yersinia pseudotuberculosis und/oder zur Differzierung zwischen Yersinia pestis und Yersinia pseudotuberculosis
EP1493028A4 (fr) * 2001-07-06 2006-06-14 Genentech Inc Ligands du domaine pdz exprimes a la surface des phages
AU2003291558B2 (en) * 2001-08-03 2009-08-13 Arbor Vita Corporation Molecular interactions in neurons
JP2003199459A (ja) 2002-01-07 2003-07-15 Japan Science & Technology Corp リンパ球遊走制御機能欠失モデル非ヒト動物
DK2377546T3 (en) 2004-12-21 2017-02-13 Musc Found For Res Dev Compositions and Methods to Promote Wound Healing and Tissue Regeneration
AU2012202117B2 (en) * 2004-12-21 2014-06-26 Musc Foundation For Research Development Compositions and methods for promoting wound healing and tissue regeneration
US9408381B2 (en) 2004-12-21 2016-08-09 Musc Foundation For Research Development Alpha Connexin c-Terminal (ACT) peptides for use in transplant
AU2006229687B2 (en) * 2005-02-24 2011-08-11 The Scripps Research Institute Isolated myeloid-like bone marrow cell populations and methods of treatment therewith
CN101287988B (zh) * 2005-07-01 2012-10-10 阿波维塔公司 用于流感诊断和治疗的方法和组合物
EP2172210A1 (fr) * 2005-12-23 2010-04-07 Partnership&Corp. Technology Transfer Peptide synthétique et utilisation comme inhibiteur de la sécrétion de neurotransmitteur
JP5296530B2 (ja) * 2006-04-07 2013-09-25 国立大学法人 筑波大学 移植片対宿主病予知マーカーおよびその利用
AU2013225716B2 (en) 2012-03-01 2017-10-12 Xequel Bio, Inc. Topical gels containing alpha connexin C-terminal (ACT) peptides
CN114010788A (zh) 2014-08-22 2022-02-08 奥克兰联合服务有限公司 通道调节剂
JP2020518275A (ja) * 2017-05-03 2020-06-25 バイオマリン ファーマシューティカル インコーポレイテッド 造血幹細胞の形質導入のための改善されたレンチウイルス
JP7773195B2 (ja) * 2018-12-20 2025-11-19 ザ・ユニバーシティ・オブ・シカゴ がん治療のための治療用ペプチドに関する方法および組成物
EP4199947A4 (fr) 2020-08-18 2024-10-16 Onchilles Pharma, Inc. Protéines d'élastase pancréatique porcine modifiées
US12138293B2 (en) 2020-10-22 2024-11-12 Xequel Bio, Inc. Peptide formulations and ophthalmic uses thereof
CN114457005B (zh) * 2022-01-12 2024-03-26 佛山市妇幼保健院 一种小儿尿道平滑肌细胞的分离纯化方法
WO2024199407A1 (fr) * 2023-03-31 2024-10-03 Qihan Hong Kong Limited Immunothérapies cancéreuses à l'aide de cellules modifiées

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998005347A1 (fr) * 1996-07-22 1998-02-12 The Trustees Of Columbia University In The City Of New York Composes inhibiteurs de l'interaction entre proteines transductrices de signaux et le domaine glgf (pdz/dhr), et utilisation de tels composes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998005347A1 (fr) * 1996-07-22 1998-02-12 The Trustees Of Columbia University In The City Of New York Composes inhibiteurs de l'interaction entre proteines transductrices de signaux et le domaine glgf (pdz/dhr), et utilisation de tels composes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GEE STEPHEN H ET AL: "Cyclic peptides as non-carboxyl-terminal ligands of syntrophin PDZ domains.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 34, 21 August 1998 (1998-08-21), pages 21980 - 21987, XP002155720, ISSN: 0021-9258 *
SARAS J ET AL: "PDZ domains bind carboxy-terminal sequences of target proteins", TIBS TRENDS IN BIOCHEMICAL SCIENCES,EN,ELSEVIER PUBLICATION, CAMBRIDGE, vol. 21, no. 12, 1 December 1996 (1996-12-01), pages 455 - 458, XP004063028, ISSN: 0968-0004 *
SCHEPENS JAN ET AL: "The neuronal nitric oxide synthase PDZ motif binds to -G(D,E)XV carboxy terminal sequences.", FEBS LETTERS, vol. 409, no. 1-2, 1997, pages 53 - 56, XP002156006, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
WO2000069897A9 (fr) 2002-07-04
WO2000069896A9 (fr) 2002-10-03
WO2000069897A3 (fr) 2001-11-08
WO2000069896A2 (fr) 2000-11-23
JP2011102326A (ja) 2011-05-26
WO2000069897A2 (fr) 2000-11-23
EP1178817A2 (fr) 2002-02-13
JP2002543825A (ja) 2002-12-24
ES2436624T3 (es) 2014-01-03

Similar Documents

Publication Publication Date Title
WO2000069896A3 (fr) Interactions moleculaires dans les cellules hematopoietiques
WO2002042422A3 (fr) Interactions moleculaires dans des cellules hematopoietiques
AU2023199A (en) Methods, systems, and kits for intravascular nucleic acid delivery
EP0830459A4 (fr) Systemes d'hybrides doubles inverses
WO2003014303A3 (fr) Interactions moleculaires dans les cellules
CA2383926A1 (fr) Genomique fonctionnelle utilisant des proteines a doigts de zinc
WO2001018248A3 (fr) Signalisation de detection de quorum chez des bacteries
WO2001040798A3 (fr) Procede d'utilisation de banques de proteines a doigt de zinc randomisees, pour l'identification d'une fonction de genes
EP1009440A4 (fr) Procedes d'inhibition de reponses associees a l'adn immunostimulateur
WO2000012726A3 (fr) Heparinases a conception rationnelle derivees de l'heparinase i et ii
WO1996034113A3 (fr) Procedes d'identification d'inhibiteurs de transferases de farnesyl
AU1339701A (en) Anti-cancer nucleic acid and protein targets
WO2001096604A3 (fr) Analyse de polymorphismes genetiques a l'aide de marqueurs detectables a la lumiere diffusee
EP0821693A4 (fr) Nouvelles sequences d'adn du cytomegalovirus humain
AU1728001A (en) Oligonucleotides and assemblies thereof useful in the detection of the presence or absence of target nucleic acid sequences in a sample
AU2002952797A0 (en) Centrifugal device and method using same
WO2002031512A3 (fr) Interactions moleculaires dans des cellules hematopoietiques
CA2278808A1 (fr) Procedes pour la culture de cellules et la multiplication de virus
WO2001009384A3 (fr) Analyse en serie d'alterations genetiques
CA2361987A1 (fr) Proteine de liaison a l'antigene du syndrome de goodpasture
AU1727597A (en) Purified sr-p70 protein
WO2000069898A3 (fr) Interactions moleculaires dans les reactions allergiques
AU2001256232A1 (en) Genes isolated from dendritic cells, gene products and methods employing the same
TR199902434T2 (xx) Bakteriyel plazmidler.
AU1771799A (en) Acetyl-coa-carboxylase from candida albicans

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US US US US US US US US US US US US US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US US US US US US US US US US US US US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 618312

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2000932386

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000932386

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

AK Designated states

Kind code of ref document: C2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US US US US US US US US US US US US US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

COP Corrected version of pamphlet

Free format text: PAGES 21, 22, 29-45 AND 53, DESCRIPTION, REPLACED BY NEW PAGES 21, 22, 29-45 AND 53; PAGES 1/14-14/14, DRAWINGS, REPLACED BY NEW PAGES 1/14-14/14; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE