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WO2000068863A1 - Procede et dispositif pour imagerie tomosynthetique - Google Patents

Procede et dispositif pour imagerie tomosynthetique Download PDF

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Publication number
WO2000068863A1
WO2000068863A1 PCT/FI2000/000404 FI0000404W WO0068863A1 WO 2000068863 A1 WO2000068863 A1 WO 2000068863A1 FI 0000404 W FI0000404 W FI 0000404W WO 0068863 A1 WO0068863 A1 WO 0068863A1
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WO
WIPO (PCT)
Prior art keywords
images
summed
image information
sensor
imaging
Prior art date
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Ceased
Application number
PCT/FI2000/000404
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English (en)
Inventor
Kustaa Nyholm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Planmeca Oy
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Planmeca Oy
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Filing date
Publication date
Application filed by Planmeca Oy filed Critical Planmeca Oy
Priority to AU44082/00A priority Critical patent/AU4408200A/en
Publication of WO2000068863A1 publication Critical patent/WO2000068863A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/025—Tomosynthesis
    • G06T12/10—
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2211/00—Image generation
    • G06T2211/40—Computed tomography
    • G06T2211/436—Limited angle

Definitions

  • the present invention relates to a tomosynthetic imaging method in which method the target to be imaged is transillu- minated by means of the radiation obtained from a radiation source, the said radiation being detected by means of an electric radiation detector and images of the target being taken from different directions.
  • the said invention also relates to an apparatus in tomosynthetic imaging which apparatus encompasses a radiation source, an electric radiation detector, means for moving at least either of these with regard to the target to be imaged, a unit for controlling the motion of the radiation source and/or the detector, and means for processing the image information.
  • Tomosynthesis is an imaging method generally known in the field of magnetic and x-ray imaging. It involves taking im- ages of the target at different angles and summing them in such a way that they overlap in the desired manner, so as to sum and overlap the points of interest in the target and to blur invisible the features that are outside of the layer concerned.
  • the image data can be manipulated in the desired manner later, the layer to be imaged can be selected arbitrarily, and the image of the desired layer improved, for example, by subtracting from it images of the other layers. This can be repeated iteratively.
  • the tomographic angle that is, the angle of projection between primary images
  • the thickness of the layer which is imaged of the target at the image manipula- tion stage in that the greater the angle, the thinner the layer imaged.
  • the angles between different images do not have to be identical, though they usually are.
  • the angles need not be on the same plane either but the target can be imaged at different angles in 3D set of coordi- nates, which generally contributes to blurring of the unde- sired layers.
  • the scope of blurring is inversely proportional to the number of transillumination images N in that the features of the unwanted layers dim away by a coefficient 1/N.
  • sampling frequency 2 x the highest frequency of interest.
  • the distance travelled by the ray in the layer to be imaged the pixel size of the sensor, including magnification.
  • the vertical direction will give us 720 pixels, in which case the size of one transillumination image will be approximately 1,2 megapixels.
  • the re- cording of the amount of information produced by a beam of width 30 mm in imaging that utilises the FT technology (Frame Transfer) would require approximately 180 megabytes of memory.
  • the implementation of tomosynthesis in such a way would require such a large number of images that it would be extremely difficult and time-consuming to record and process the result- ing quantities of data using the information processing equipment available at present.
  • the US patent publication 5,195,114 representing prior art in the field, describes a type of equipment applicable to digital imaging.
  • the said equipment encompasses a x-ray source that rotates around the target to be imaged, a x-ray detector, and means for recording and processing the image data.
  • the panoramic imaging of the human dental arch produces 900 images the recording of which requires an enormous memory capacity.
  • the distance between the individual images would be approximately 0.3 mm, which in the beam widths typically employed in the aforementioned context would mean that the target would only be presented in approximately 13 images .
  • the maximum blurring ratio would thus be 1/13.
  • the obtaining of satisfactory images would in practise require the use of a wider beam or the taking of images at shorter intervals, that is, the recording of an even larger number of images.
  • a semiconductor sensor has been presented in the international patent publication WO 95/33332 in which sensor x-ray radiation is converted directly to electric form.
  • the losses resulting from collecting the image data by means of this type of sensor are much smaller than those produced by the sensor employed in the solution that is presented in the US patent publication 5,677,940, and the tomosynthetic images that can be achieved by the said type of sensors are of a better resolution.
  • a prior art technique in medical imaging is the use of actual computer tomography in which the target is generally imaged in slices from all directions and the resulting image data are recorded, after which an image can be formed of any part of the target by calculatory means using methods based on the so-called Radon transformation, or other calculation methods.
  • the equipment used in computer tomography are extremely expensive, however, the images obtained are typically quite granular, and large doses of radiation have to be employed in order to obtain noise-free images. As a rule, the use of equipment of this kind is not possible nor justified in particular in dental x-ray imaging.
  • Digital technology aids the work of doctors, among other things, in that it allows not only for the taking of more high-quality images and thus the making of more accurate diagnoses, but also al- lows for recording and administering the images in electric form together with all other documentation relating to the patients .
  • the objective of the present invention is to create a method for tomosynthetic imaging, in which method the aforementioned objectives have been approached and problems solved.
  • Another objective is to create an apparatus which allows for implementing the method according to the invention.
  • the primary objective of the said invention is to create a tomosynthetic method in which at least the number of images to be recorded permanently can be reduced, thereby also cutting down equipment costs and speeding up image processing in the forming of cross-sectional images.
  • the methodological and equipment solutions, according to the invention allow for to- mosynthetic imaging that can be implemented using a known information processing technology and the existing equipment, without the need for a large memory capacity.
  • An essential feature of the invention is that the data obtained from imaging are not actually, that is, as such and/or permanently, recorded, but the primary image data are first pre-summed and it is the resulting pre-summed image data which are then recorded.
  • the number of images used for forming tomosynthetic images is reduced by pre-summing adjacent images, that is, images taken at almost parallel angles, either upon reading the image data and/or after that. It is only then that the pre-summed images are recorded in the non-volatile memory, and the actual tomosynthetic image is formed on the basis of the said pre-summed images .
  • the amount of information to be recorded can be reduced substantially in all types of tomosynthetic imaging re- gardless of the application and implementation concerned, thus also in light-based transillumination, for example.
  • a preferable solution, according to the invention, is to divide primary images into groups that are composed of more or less the same number of images, and even in such a way that the angle between the images that form a given group is small.
  • the angle between the groups can also be arranged to be of desired magnitude. All the desired layers within a relatively large distance on both sides of the default layer can be formed on the basis of the pre-summed images.
  • the pre-summing is performed after the imaging stage on the basis of the image data recorded in the scratch pad memory, the processing time required by the actual tomosynthesis stage can be reduced.
  • not all primary images have to be recorded, not even in the scratch pad memory, if at least some of the pre-summing is performed at the imaging stage . This will reduce the required storage capacity even further .
  • the radiation in x- ray imaging the radiation is detected by means of a sensor that converts x-ray radiation directly to an electric signal.
  • the said sensor is a TDI sensor (Time Delay Integration) which utilises CCD technology (Charge Coupled Device) , in which case pre-summing can be conducted directly in the sensor at the image data reading stage.
  • Figure 1 shows the imaging stage in tomosynthetic imaging.
  • Figures 2a and 2b show the principle employed in forming cross-sectional images in tomosynthesis.
  • Figures 3a, 3b, 3c and 3d show the principle, according to the invention, for pre-summing primary images and forming the cross-sectional images on the basis of the pre-summed images.
  • Figure 4 shows a piece of tomosynthetic imaging equipment, according to the invention, in the form of a block diagram.
  • Figure 5 shows one preferred embodiment of the invention in the panoramic imaging of the human dental arch.
  • Figures 6a and 6b show one radiation detector arrangement ap- plicable to be used in the invention.
  • Figure 1 shows the principle employed at the imaging stage in tomosynthetic imaging.
  • the target to be imaged is indicated in the figure by X and the cross-sectional layers of the target X by LI, L2, L3 and Lx.
  • three images SI, S2 and S3 are taken of the target X by placing the radiation source 11 in the places R' , R' ' and R' ' ' and moving the radiation detector 12 correspondingly.
  • the angle al, a2 between the images determines the tomographic angle T of the synthesised image. If all the images SI, S2 and S3 are summed to form a tomosynthetic image, the tomographic angle T of the resulting cross-sectional image will be al + a2.
  • the imaging stage can also be implemented by keeping the ra- diation source 11, for example, stationary and moving the target to be imaged X and the radiation detector 12, or by keeping the radiation detector 12 stationary and moving the radiation source 11 and the target to be imaged X.
  • Figures 2a and 2b show the formation of the cross-sectional images PI and P2 according to the prior art on the basis of the images SN at the image manipulation stage.
  • the images SN taken of the target X are summed in such a way that the features contained in a layer of the target X, which layer is assumed to be of interest, are imaged more ac- curately than the other layers.
  • the images SI, S3 and S5 in Figure 2a correspond to the images SI, S2 and S3 in Figure 1 and the images S2 and S4 to the projections imaged between these
  • the resulting tomosynthetic image PI in Figure 2a would roughly represent the cross- sectional layer LI shown in Figure 1.
  • Figures 3a, 3b, 3c and 3d show the principle of the pre- summing method, according to the invention.
  • the pre-summed images Zl and Z2 are formed on the basis of the images SI, S2 and S3 that have been taken over the area of one tomographic angle, and on the basis of the images S4, S5 and S6 that in turn have been taken over the area of another tomographic angle, respectively.
  • the preferable embodiments of the present invention are based on the finding that if each pre-summing is performed over an area of a sufficiently small tomographic angle aN to form a suitable default layer Lx, which layer can be the assumed centre of the target to be imaged, for example, the number of images for use as the material for tomosynthetic image manipulation will be considerably smaller than the number required if no pre-summing was employed, and yet the pre-summed images will be almost equivalent to primary ones.
  • the pre- summed images Zl and Z2 can be recorded in the non-volatile memory in which case an unlimited number of the cross- sectional images PN, the layer thickness of which is determined by the tomographic angle T, can be formed later using known tomosynthesis methods.
  • the images PI and P2 were formed from the pre-summed images Zl and Z2 on the basis of two cross-sectional layers by positioning the pre-summed images to overlap in different ways.
  • the best result, according to the invention can be obtained by forming the pre-summed images ZN over the area of a small tomographic angle aN, which only causes minor blurring of the external features of the default layer.
  • the angle of the pre-summed images ZN can be thought to represent the mean of the angles at which the images used in the pre-summing were taken.
  • the minor blurring that occurs in pre-summing delimits the allowed distance between the default layer Lx and the cross-sectional layer of the image formed at the actual tomo- synthesis stage.
  • the method enables the pre-summed images ZN to be recorded in a space considerably smaller than that required by the recording of the primary images SN.
  • the pre-summed images ZN can also be processed faster on account of their smaller number.
  • the pre-summing can be performed at the imaging stage as new image information is created or once the imaging process has been completed.
  • the actual cross- sectional image is formed only after the collection and pre- summing of the entire image data.
  • the pre-summed images can be formed on the basis of image data that e.g. correspond to 5-50 images which are purely composed of primary image information, preferably perhaps on the basis of information equivalent to 10-20 images, and the actual tomosynthetic image e.g. on the basis of 5-100 pre-summed images, possibly 10-50 images.
  • the tomographic angle between the images to be pre-summed could be less than 5 degrees, for example, preferably not exceeding 1 degree, and the tomographic angle between the pre-summed images 1-45 degrees, for example, possibly 2-20 degrees.
  • the block diagram in Figure 4 shows a piece of equipment by means of which the tomosynthetic method, according to the invention, can be implemented.
  • the said equipment encompasses the radiation source 11, radiation detector 12, pre-summing unit 13, scratch pad memory 14, mass or non-volatile memory 15, a unit 16 for controlling the motion of the imaging equipment, the display 17, summing unit 18 and user interface 19.
  • the motion control unit 16 controls the reciprocal motion of the radiation source 11 and radiation detector 12 with regard to the target to be imaged X.
  • the radiation detector 12 preferably converts the radiation, e.g. x-ray radiation, used for transillumination, directly to an electric signal.
  • the signal is then converted to digital form and sent to the pre-summing unit 13 which is already capable of starting the process of pre-summing the primary images at the imaging stage with the help of the scratch pad memory 14 and the imaging equipment motion information 16.
  • the scope of the pre-summing covers the desired number of images preferably taken over an area of a small tomographic angle and the resulting images are recorded in the mass storage 15.
  • the desired cross-sectional layer can be selected later on an arbitrary basis via the user interface 19, keeping in mind the limiting conditions discussed above, which cross-sectional layer is calculated in the summing unit 18 and presented on the display 17.
  • the cross-sectional layer can be selected in such a way that it passes through the target at any angle, or it can be a cylinder surface, for example.
  • Tomosynthetic images can be taken using a panoramic x-ray apparatus in which images of the target are taken by using a x- ray detector and a x-ray source capable of rotating around the target.
  • a very narrow x-ray beam e.g. of width 4-20 mm is employed, and as the x-ray detector a receiver is used by means of which the image information can be converted to electric form and from it to digital form.
  • the radiation obtained from the radiation source 11 is directed through the target to be imaged X by means of the radiation detector 12, each of the vertical pixel rows of which can be considered to form a single-row sensor.
  • the apparatus produces, on the known slit imaging principle, the images SN that are essentially equivalent to transillumination images, that is, the first vertical row of the sensor produces the image SI, the second the image S2 etc.
  • the resulting primary images SN can be recorded in the temporary memory as such.
  • the image in- formation which is created at the first point in time during the imaging process and which is to be summed to each of the be pre-summed images that will, is recorded, in which case the rest of the image data to be pre-summed to each image are summed directly to the image information recorded in the said scratch pad memory as they are generated during the imaging process .
  • the radiation detector 12 can also be provided to encompass sensor columns composed of several rows in which case the pre- summing can be performed by summing directly on the sensor the image information produced by the individual rows in each column, which summing already takes place upon the reading of the image data.
  • the image information read from the sensor does not correspond to the images SN shown in Figure 5 , which images are purely composed of primary image data, but to the images ZN that have already been pre-summed and can be recorded directly.
  • the present invention can be implemented by using any sensor technology.
  • a preferable solution in x-ray applications is to utilise a technology that enables x-ray radiation to be converted directly to electric form. This allows for reducing the loss encountered with more traditional sensor technologies in which the x-ray radiation first has to be converted to light, then to electric form, and finally to digital form.
  • a useful feature of the MOS technology which is one of the more traditional sensor technologies, is that the image data collected on the sensor can be read directly from individual pixels. This eliminates the problem encountered in the CCD technology, in which the image data read also carry unwanted signal when the pixel charges are transferred from the image information reception area to the charges reading area via the neighbouring pixels . The problem can of course be minimised even with the CCD technology by utilising a sensor of the FT type in which case the pre-summing of the image data, according to the invention, is performed electronically or program- matically before the permanent recording of the information.
  • one prefer- able way of pre-summing is to use the CCD sensor as the radiation detector, which sensor is composed of several narrow, parallel TDI sensor columns and which sensor pre-sums the image data automatically at the image data reading stage.
  • This solution allows for the avoiding of losses and interference at the pre-summing stage, and for reducing the speed required by AD conversion compared to that required by electronic or programmatic pre-summing. It is also preferable to place a recording/reading register beside each integration register so as to gain more time for the reading of data from the sensor.
  • Figure 6a shows the radiation detector 12' which has been divided into several columns, or in fact into narrow CCD sensor columns that operate on the TDI principle.
  • Figure 6b shows one column or bar 12', according to Figure 6a, which column or bar encompasses an image information reception area 20, integration register 21 located beside the reception area 20, and preferably also a recording/reading register 22 provided beside the integration register 21.
  • the detector 12 is moved pass the target to be imaged during which movement the said detector 12 is constantly receiving radiation, e.g. x-ray radiation, that passes through the target .
  • the means provided on the surface of the sensor, not shown in the said figure, thereby convert the radiation to light that contains image information.
  • the pixels located in the reception area 20 convert the said light to an electric charge that corresponds to the intensity of light.
  • the charges are transferred, one pixel at a time and controlled by the column clocks 25, towards the integration register 21 in which they are summed and the image data read 23 from the sensor via the recording/reading register 22 and controlled by the row clock 24.
  • the image information read from each narrow sensor bar 12' is already in pre-summed form, according to the invention, the said pre-summing covering an area that comprises the width of the beam read by the sensor column and the tomographic angle that determines the rest of the imaging geometry.
  • the tomosynthetic method and apparatus can be applied to the imaging of any target using x-ray radiation, or any other radiation that can be used for tran- sillumination purposes .
  • the present invention lends itself most particularly to use in the x-ray imaging of the human skull, such as panoramic and other cross-sectional imaging of the dental arch, and in mammography.
  • the implementation of the present invention is not restricted by the application of any particular sensor technology.
  • the present invention preferably also allows for the use of sensors that are based on the direct detection of x-ray radiation.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus For Radiation Diagnosis (AREA)

Abstract

Cette invention concerne un procédé et un dispositif d'imagerie tomosynthétique qui consistent à éclairer par transparence la cible à visualiser au moyen d'un rayonnement émis par une source de rayonnement. Ledit rayonnement est détecté au moyen d'un détecteur de rayonnement électrique. Les images de la cible sont prises selon des directions différentes. Une des caractéristiques majeures de cette invention tient au fait qu'avant d'enregistrer les données images recueillies au cours du processus de visualisation, on réduit le volume desdites données image en totalisant préalablement les données image primaires de manière à obtenir un nombre plus faible d'images pré-totalisées dont les propriétés correspondent quasiment à celles des images primaires, lesquelles images pré-totatisées sont alors enregistrées. De plus, cette invention permet d'exécuter une tomosynthèse avec un matériel autres que ceux dotés d'une mémoire et d'une capacité de traitement de l'information considérables.
PCT/FI2000/000404 1999-05-06 2000-05-05 Procede et dispositif pour imagerie tomosynthetique Ceased WO2000068863A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU44082/00A AU4408200A (en) 1999-05-06 2000-05-05 Method and apparatus for tomosynthetic imaging

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI991036A FI991036L (fi) 1999-05-06 1999-05-06 Tomosynteesimenetelmä ja laite tomosynteesikuvantamisessa
FI991036 1999-05-06

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WO2000068863A1 true WO2000068863A1 (fr) 2000-11-16

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FI (1) FI991036L (fr)
WO (1) WO2000068863A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6611575B1 (en) 2001-07-27 2003-08-26 General Electric Company Method and system for high resolution 3D visualization of mammography images
WO2002093943A3 (fr) * 2001-05-16 2004-04-29 Koninkl Philips Electronics Nv Procede et dispositif permettant la visualisation d'un ensemble de donnees 3d
US7085406B2 (en) 2001-07-27 2006-08-01 General Electric Company Method and system for unsupervised transfer function generation for images of rendered volumes
US10638994B2 (en) 2002-11-27 2020-05-05 Hologic, Inc. X-ray mammography with tomosynthesis
US11471118B2 (en) 2020-03-27 2022-10-18 Hologic, Inc. System and method for tracking x-ray tube focal spot position
US11510306B2 (en) 2019-12-05 2022-11-22 Hologic, Inc. Systems and methods for improved x-ray tube life
US12414217B2 (en) 2022-02-07 2025-09-09 Hologic, Inc. Systems and methods for adaptively controlling filament current in an X-ray tube

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482958A (en) * 1980-11-17 1984-11-13 Tokyo Shibaura Denki Kabushiki Kaisha Data processing device for computed tomography system
WO1998000063A1 (fr) * 1996-07-01 1998-01-08 Stefan Nilsson Procede tomodensitometrique et tomodensitometre

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482958A (en) * 1980-11-17 1984-11-13 Tokyo Shibaura Denki Kabushiki Kaisha Data processing device for computed tomography system
WO1998000063A1 (fr) * 1996-07-01 1998-01-08 Stefan Nilsson Procede tomodensitometrique et tomodensitometre

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002093943A3 (fr) * 2001-05-16 2004-04-29 Koninkl Philips Electronics Nv Procede et dispositif permettant la visualisation d'un ensemble de donnees 3d
US6931093B2 (en) 2001-05-16 2005-08-16 Koninklijke Philips Electronics N.V. Method and apparatus for visualizing a 3D data set
US6611575B1 (en) 2001-07-27 2003-08-26 General Electric Company Method and system for high resolution 3D visualization of mammography images
US7085406B2 (en) 2001-07-27 2006-08-01 General Electric Company Method and system for unsupervised transfer function generation for images of rendered volumes
US10638994B2 (en) 2002-11-27 2020-05-05 Hologic, Inc. X-ray mammography with tomosynthesis
US11096644B2 (en) 2003-11-26 2021-08-24 Hologic, Inc. X-ray mammography with tomosynthesis
US11510306B2 (en) 2019-12-05 2022-11-22 Hologic, Inc. Systems and methods for improved x-ray tube life
US11471118B2 (en) 2020-03-27 2022-10-18 Hologic, Inc. System and method for tracking x-ray tube focal spot position
US12414217B2 (en) 2022-02-07 2025-09-09 Hologic, Inc. Systems and methods for adaptively controlling filament current in an X-ray tube

Also Published As

Publication number Publication date
FI991036A0 (fi) 1999-05-06
AU4408200A (en) 2000-11-21
FI991036A7 (fi) 2000-11-07
FI991036L (fi) 2000-11-07

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