[go: up one dir, main page]

WO2000067788A3 - Emploi de molecules de co-stimulation solubles favorisant les reponses immunitaires - Google Patents

Emploi de molecules de co-stimulation solubles favorisant les reponses immunitaires Download PDF

Info

Publication number
WO2000067788A3
WO2000067788A3 PCT/US2000/012435 US0012435W WO0067788A3 WO 2000067788 A3 WO2000067788 A3 WO 2000067788A3 US 0012435 W US0012435 W US 0012435W WO 0067788 A3 WO0067788 A3 WO 0067788A3
Authority
WO
WIPO (PCT)
Prior art keywords
immune responses
costimulatory molecules
enhance immune
soluble costimulatory
molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/012435
Other languages
English (en)
Other versions
WO2000067788A2 (fr
Inventor
Knut Sturmhoefel
Stanley F Wolf
Margot O'toole
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP00930437A priority Critical patent/EP1181053A2/fr
Priority to JP2000616813A priority patent/JP2002544170A/ja
Priority to PL36091500A priority patent/PL360915A1/xx
Priority to CA002373256A priority patent/CA2373256A1/fr
Priority to AU48257/00A priority patent/AU4825700A/en
Priority to IL14610600A priority patent/IL146106A0/xx
Priority to BR0010711-5A priority patent/BR0010711A/pt
Priority to HK02102335.8A priority patent/HK1041810A1/zh
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Priority to KR1020017014170A priority patent/KR20020001865A/ko
Publication of WO2000067788A2 publication Critical patent/WO2000067788A2/fr
Publication of WO2000067788A3 publication Critical patent/WO2000067788A3/fr
Priority to NO20015396A priority patent/NO20015396L/no
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5152—Tumor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Cette invention concerne des méthodes propres à favoriser des réponses immunitaires, selon lesquelles on administre des formes solubles de molécules de co-stimulation, telles que des molécules B7, pour accroître les réponses immunitaires à des antigènes tels que des cellules tumorales ou des agents infectieux. Les méthodes selon l'invention conviennent à titre tant prophylactique et thérapeutique pour l'immunisation de sujets.
PCT/US2000/012435 1999-05-06 2000-05-05 Emploi de molecules de co-stimulation solubles favorisant les reponses immunitaires Ceased WO2000067788A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
BR0010711-5A BR0010711A (pt) 1999-05-06 2000-05-05 Uso de moléculas co-estimulatórias solúveis para intensificar respostas imunes
PL36091500A PL360915A1 (en) 1999-05-06 2000-05-05 Use of soluble costimulatory molecules to enhance immune responses
CA002373256A CA2373256A1 (fr) 1999-05-06 2000-05-05 Emploi de molecules de co-stimulation solubles favorisant les reponses immunitaires
AU48257/00A AU4825700A (en) 1999-05-06 2000-05-05 Use of soluble costimulatory molecules to enhance immune responses
IL14610600A IL146106A0 (en) 1999-05-06 2000-05-05 Use of soluble costimulatory molecules to enhance immune responses
EP00930437A EP1181053A2 (fr) 1999-05-06 2000-05-05 Emploi de molecules de co-stimulation solubles favorisant les reponses immunitaires
JP2000616813A JP2002544170A (ja) 1999-05-06 2000-05-05 免疫応答を高めるための可溶性同時刺激分子の使用
HK02102335.8A HK1041810A1 (zh) 1999-05-06 2000-05-05 增加免疫反应的可溶性共同刺激分子的用途
KR1020017014170A KR20020001865A (ko) 1999-05-06 2000-05-05 면역반응을 증강시키기 위한 가용성 공동자극 분자의 용도
NO20015396A NO20015396L (no) 1999-05-06 2001-11-05 Anvendelse av löselige kostimulerende molekyler for å forsterke immunresponser

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13294499P 1999-05-06 1999-05-06
US60/132,944 1999-05-06

Publications (2)

Publication Number Publication Date
WO2000067788A2 WO2000067788A2 (fr) 2000-11-16
WO2000067788A3 true WO2000067788A3 (fr) 2001-04-05

Family

ID=22456295

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/012435 Ceased WO2000067788A2 (fr) 1999-05-06 2000-05-05 Emploi de molecules de co-stimulation solubles favorisant les reponses immunitaires

Country Status (15)

Country Link
EP (1) EP1181053A2 (fr)
JP (1) JP2002544170A (fr)
KR (1) KR20020001865A (fr)
CN (1) CN1377279A (fr)
AU (1) AU4825700A (fr)
BR (1) BR0010711A (fr)
CA (1) CA2373256A1 (fr)
CZ (1) CZ20013964A3 (fr)
HK (1) HK1041810A1 (fr)
HU (1) HUP0201222A3 (fr)
IL (1) IL146106A0 (fr)
NO (1) NO20015396L (fr)
PL (1) PL360915A1 (fr)
WO (1) WO2000067788A2 (fr)
ZA (1) ZA200109376B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3521382B2 (ja) 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
US7112655B1 (en) 1997-02-27 2006-09-26 Japan Tobacco, Inc. JTT-1 protein and methods of inhibiting lymphocyte activation
JP3871503B2 (ja) 1999-08-30 2007-01-24 日本たばこ産業株式会社 免疫性疾患治療剤
JP4210454B2 (ja) 2001-03-27 2009-01-21 日本たばこ産業株式会社 炎症性腸疾患治療剤
JP3597140B2 (ja) 2000-05-18 2004-12-02 日本たばこ産業株式会社 副刺激伝達分子ａｉｌｉｍに対するヒトモノクローナル抗体及びその医薬用途
JP4212278B2 (ja) 2001-03-01 2009-01-21 日本たばこ産業株式会社 移植片拒絶反応抑制剤
EP2292628A3 (fr) * 2005-06-30 2011-05-11 Eisai R&D Management Co., Ltd. Composés pour préparer un adjuvant immunologique
MX2008007287A (es) 2005-12-08 2008-10-27 Univ Louisville Res Found Metodos y composiciones para expandir celulas reguladoras t.
US20070172504A1 (en) 2005-12-08 2007-07-26 University Of Lousville Research Foundation, Inc. In vivo cell surface engineering
US9511151B2 (en) * 2010-11-12 2016-12-06 Uti Limited Partnership Compositions and methods for the prevention and treatment of cancer
KR20140050698A (ko) * 2011-07-29 2014-04-29 셀렉타 바이오사이언시즈, 인크. 체액성 및 세포독성 t 림프구(ctl) 면역 반응을 발생시키는 합성 나노운반체
US10988516B2 (en) 2012-03-26 2021-04-27 Uti Limited Partnership Methods and compositions for treating inflammation
WO2013151731A1 (fr) * 2012-04-02 2013-10-10 The Arizona Board Of Regents For And On Behalf Of Arizona State University Bactérie recombinante pour induire une réponse immunitaire cellulaire
US9603948B2 (en) 2012-10-11 2017-03-28 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
CN105899229A (zh) 2013-11-04 2016-08-24 Uti有限合伙公司 用于持续的免疫治疗的方法和组合物
WO2016198932A2 (fr) 2015-05-06 2016-12-15 Uti Limited Partnership Compositions de nanoparticules pour thérapie prolongée
EP3716949A4 (fr) 2017-11-29 2022-05-18 UTI Limited Partnership Méthodes de traitement d'une maladie auto-immune
CN110743006B (zh) * 2019-11-22 2020-08-25 北京启辰生生物科技有限公司 用于协同解除免疫细胞衰竭的组合物及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000006605A2 (fr) * 1998-07-28 2000-02-10 Micromet Ag Heterominicorps

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000006605A2 (fr) * 1998-07-28 2000-02-10 Micromet Ag Heterominicorps

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEN AOSHUANG ET AL: "Non-glycosylated human B7-1(CD80) retains the capacity to bind its counter-receptors.", FEBS LETTERS, vol. 428, no. 3, 29 May 1998 (1998-05-29), pages 127 - 134, XP002154489, ISSN: 0014-5793 *
MORO MONICA ET AL: "Induction of therapeutic T-cell immunity by tumor targeting with soluble recombinant B7-immunoglobulin costimulatory molecules.", CANCER RESEARCH, vol. 59, no. 11, 1 June 1999 (1999-06-01), pages 2650 - 2656, XP002154490, ISSN: 0008-5472 *
RAO JAY B ET AL: "IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: Enhancement by simultaneous B7-1 expression.", JOURNAL OF IMMUNOLOGY, vol. 156, no. 9, 1996, pages 3357 - 3365, XP002154488, ISSN: 0022-1767 *
RENNERT PAUL ET AL: "The IgV domain of human B7-2 (CD86) is sufficient to co-stimulate T lymphocytes and induce cytokine secretion.", INTERNATIONAL IMMUNOLOGY, vol. 9, no. 6, 1997, pages 805 - 813, XP000971089, ISSN: 0953-8178 *

Also Published As

Publication number Publication date
KR20020001865A (ko) 2002-01-09
WO2000067788A2 (fr) 2000-11-16
CA2373256A1 (fr) 2000-11-16
HK1041810A1 (zh) 2002-07-26
NO20015396D0 (no) 2001-11-05
NO20015396L (no) 2002-01-02
EP1181053A2 (fr) 2002-02-27
CZ20013964A3 (cs) 2002-06-12
HUP0201222A2 (en) 2002-08-28
IL146106A0 (en) 2002-07-25
ZA200109376B (en) 2003-03-13
AU4825700A (en) 2000-11-21
BR0010711A (pt) 2002-02-13
CN1377279A (zh) 2002-10-30
HUP0201222A3 (en) 2004-07-28
JP2002544170A (ja) 2002-12-24
PL360915A1 (en) 2004-09-20

Similar Documents

Publication Publication Date Title
HK1041810A1 (zh) 增加免疫反应的可溶性共同刺激分子的用途
WO1999033868A3 (fr) Vaccin
WO1999010375A3 (fr) Vaccin
EP1568373A3 (fr) Induction de reponses immunes cellulaires a HER2/neu a l'aide de compositions renfermant des peptides et des acides nucleiques
EP1246644A4 (fr) Reponse immunitaire cellulaire au papillomavirus humain induite par utilisation de compositions peptidiques et d'acide nucleique
WO2002034205A3 (fr) Utilisation des proteines du stress pour stimuler la reponse immunitaire
WO2002102299A3 (fr) Procedes et compositions pharmaceutiques permettant la falsification immunitaire, particulierement utiles pour le traitement du cancer
WO2001060402A3 (fr) Vaccin antigrippal a base de proteosomes
NZ503830A (en) Papilloma virus capsomere vaccine formulations and methods of use
WO2001026681A3 (fr) Procede d'obtention de reponses immunes cellulaires de proteines
AU2002347404A1 (en) In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
WO2005002621A3 (fr) Methodes visant a eliciter, ameliorer et maintenir des reponses immunitaires dirigees contre des epitopes restreints du cmh de classe i, a des fins prophylactiques ou therapeutiques
HUP0401753A3 (en) Antigen presenting cells, method for their preparation and their use for cancer vaccines
WO2001058485A3 (fr) Anticorps monoclonaux a vocation prophylactique et therapeutique
WO1999050303A3 (fr) Complexe d'alpha-2 macroglobuline modulateur de la reponse immunitaire
IL141775A0 (en) Aglyco products and methods of use
CA2232344A1 (fr) Composition et procedes permettant d'accentuer les reponses immunitaires dues aux cellules presentatrices d'antigene
NZ505834A (en) Compositions containing polypeptides isolated from mycobacterium vaccae and methods for their use
WO2002034287A3 (fr) Nouvelles formulations de vaccin therapeutique
WO2005025497A3 (fr) Epitopes des lymphocytes t hpv cd8+
WO2002054073A3 (fr) Modele de tuberculose humaine latente, antigenes diagnostiques et methodes d'utilisation associees
WO2000061766A3 (fr) Vaccin anticancereux specifique de la telomerase
WO1997011669A3 (fr) Antigenes limites du melanome, appartenant a la classe ii du mhc, et leur utilisation dans des methodes therapeutiques
WO2004105681A3 (fr) Epitopes du papillomavirus humain (hpv) cd4+
MY127452A (en) Vaccines.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/011130

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: PV2001-3964

Country of ref document: CZ

ENP Entry into the national phase

Ref document number: 2373256

Country of ref document: CA

Ref country code: CA

Ref document number: 2373256

Kind code of ref document: A

Format of ref document f/p: F

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 616813

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1020017014170

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 515410

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2001/09376

Country of ref document: ZA

Ref document number: 200109376

Country of ref document: ZA

WWE Wipo information: entry into national phase

Ref document number: 48257/00

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2000930437

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 008100381

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 1020017014170

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 2000930437

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: PV2001-3964

Country of ref document: CZ

WWR Wipo information: refused in national office

Ref document number: PV2001-3964

Country of ref document: CZ

WWW Wipo information: withdrawn in national office

Ref document number: 2000930437

Country of ref document: EP

WWR Wipo information: refused in national office

Ref document number: 1020017014170

Country of ref document: KR