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WO2000067679A1 - Implant pour retablir une fonction valvulaire veineuse - Google Patents

Implant pour retablir une fonction valvulaire veineuse Download PDF

Info

Publication number
WO2000067679A1
WO2000067679A1 PCT/US2000/011414 US0011414W WO0067679A1 WO 2000067679 A1 WO2000067679 A1 WO 2000067679A1 US 0011414 W US0011414 W US 0011414W WO 0067679 A1 WO0067679 A1 WO 0067679A1
Authority
WO
WIPO (PCT)
Prior art keywords
vein
patch
leaflet
patient
implant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/011414
Other languages
English (en)
Inventor
Rodolfo C. Quijano
Raul Garcia-Rinaldi
Robert J. Demel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Venpro Corp
Original Assignee
Venpro Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Venpro Corp filed Critical Venpro Corp
Priority to EP00928503A priority Critical patent/EP1187581A1/fr
Priority to AU46737/00A priority patent/AU4673700A/en
Publication of WO2000067679A1 publication Critical patent/WO2000067679A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3625—Vascular tissue, e.g. heart valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2475—Venous valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2415—Manufacturing methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation

Definitions

  • Venous valves are particularly important in the arms and legs.
  • the venous system in the lower extremities generally consists of deep veins and superficial veins which lie just below the skin surface.
  • the deep and superficial veins are interconnected by perforating veins.
  • blood In the legs, blood generally flows upwards towards the heart and against the pull of gravity.
  • Venous valves aid the forward flow of blood by closing when fiow tends to reverse, thereby preventing reflux of blood.
  • Figure 8 is a perspective view of a valvular implant attached to a holding device; and Figure 9 is a top plan view of a base portion of the holding device shown in Figure 8.
  • Venous valves normally remain open during forward flow, i.e. flow of blood towards the heart, through the vein.
  • the leaflets of the valve are in an "open” position when a venous valve is open, and the leaflets are in a "closed” position when the venous valve is closed.
  • Normal flow rate of blood through the veins is generally at least 100 milliliters per minute (ml/m), and approximately 250 ml/m to about 550 ml/m.
  • the valves close upon the exertion of backflow pressure.
  • backflow is used to describe flow in a direction away from the normal forward blood flow, such as in a direction away from the heart or away from the deep veins.
  • the valvular patch 100 is surgically shaped to an appropriate size and shape, in some instances, a patch 100 of the desired size and shape is cut directly from the vein segment 112 so that additional shaping is not necessary.
  • the wall section 106 of the resulting patch 100 has a generally elliptical shape, i.e., full-sinus configuration, as shown in Figure 2.
  • Figures 2A and 2B illustrate a patch having a wail section shaped in a semi-sinus configuration and Figures 2.
  • 2D illustrate a patch having a wall section with a no-sinus configuration.
  • the reduced sinus area of the patches shown in Figures 2A-2D requires less removal of the patient's vein in order to implant the patch. Further, the amount of suturing necessary for implementation is also reduced in those embodiments.
  • a valvular leaflet from the jugular vein of a large animal may be of a sufficient size to form a valve within a human vein.
  • Figure 6 illustrates a patch having two leaflets 104, 107 implanted within the vein of a patient. In a closed position, each leaflet covers about half the cross-sectional area of the vein.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Prostheses (AREA)

Abstract

Cette invention se rapporte à un implant servant à rétablir une fonction valvulaire veineuse et qui est formé à partir d'un segment de veine de source biologique. Cet implant comprend une section paroi du segment de veine et un clapet valvulaire unique formé sur cette section paroi. La section paroi et le clapet sont excisés du segment de veine pour former une pièce de réparation. Cette pièce de réparation est implantée dans la veine d'un patient dont la valve est déficiente. La taille du clapet est choisie pour que, lorsque la valve est fermée, le clapet unique empêche pratiquement tout reflux de sang dans la veine du patient. Un dispositif de support peut être utilisé avec la pièce de réparation pour faciliter sa conservation, son transport et/ou son implantation dans le corps du patient. Ce dispositif de support comporte une partie de base et un support détachable. La partie de base peut être fixée à une surface externe de la section paroi de la pièce de réparation.
PCT/US2000/011414 1999-05-06 2000-04-28 Implant pour retablir une fonction valvulaire veineuse Ceased WO2000067679A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP00928503A EP1187581A1 (fr) 1999-05-06 2000-04-28 Implant pour retablir une fonction valvulaire veineuse
AU46737/00A AU4673700A (en) 1999-05-06 2000-04-28 Implant for restoring venous valvular function

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13289199P 1999-05-06 1999-05-06
US60/132,891 1999-05-06
US35417799A 1999-07-16 1999-07-16
US09/354,177 1999-07-16

Publications (1)

Publication Number Publication Date
WO2000067679A1 true WO2000067679A1 (fr) 2000-11-16

Family

ID=26830835

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/011414 Ceased WO2000067679A1 (fr) 1999-05-06 2000-04-28 Implant pour retablir une fonction valvulaire veineuse

Country Status (3)

Country Link
EP (1) EP1187581A1 (fr)
AU (1) AU4673700A (fr)
WO (1) WO2000067679A1 (fr)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002041764A3 (fr) * 2000-10-26 2003-04-24 Boston Scient Corp Systeme de valve implantable
WO2003084443A1 (fr) * 2002-04-03 2003-10-16 Scimed Life Systems, Inc. Valvule artificielle
WO2005013857A1 (fr) * 2003-08-05 2005-02-17 Cook Incorporated Valve veineuse implantable
US7244242B2 (en) 2002-12-30 2007-07-17 Boston Scientific Scimed, Inc. Valve treatment catheter and methods
US7267686B2 (en) 1999-10-21 2007-09-11 Boston Scientific Scimed, Inc Implantable prosthetic valve
WO2009052340A1 (fr) 2007-10-17 2009-04-23 Cook Incorporated Dispositif de valvule implantable
US7566343B2 (en) 2004-09-02 2009-07-28 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US7569071B2 (en) 2005-09-21 2009-08-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
WO2009052207A3 (fr) * 2007-10-17 2010-09-16 Hancock Jaffe Laboratories Valvule biologique pour insuffisance valvulaire veineuse
US9028542B2 (en) 2005-06-10 2015-05-12 Boston Scientific Scimed, Inc. Venous valve, system, and method
US9301843B2 (en) 2003-12-19 2016-04-05 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US9370419B2 (en) 2005-02-23 2016-06-21 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US9421083B2 (en) 2007-02-05 2016-08-23 Boston Scientific Scimed Inc. Percutaneous valve, system and method
US9622859B2 (en) 2005-02-01 2017-04-18 Boston Scientific Scimed, Inc. Filter system and method
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
US9744037B2 (en) 2013-03-15 2017-08-29 California Institute Of Technology Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves
US9861473B2 (en) 2005-04-15 2018-01-09 Boston Scientific Scimed Inc. Valve apparatus, system and method
US10940167B2 (en) 2012-02-10 2021-03-09 Cvdevices, Llc Methods and uses of biological tissues for various stent and other medical applications
US11406495B2 (en) 2013-02-11 2022-08-09 Cook Medical Technologies Llc Expandable support frame and medical device

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3988782A (en) * 1973-07-06 1976-11-02 Dardik Irving I Non-antigenic, non-thrombogenic infection-resistant grafts from umbilical cord vessels and process for preparing and using same
US4218782A (en) * 1977-05-25 1980-08-26 Biocoating Anpartsselskab Heart valve prosthesis and method for the production thereof
US4400833A (en) * 1981-06-10 1983-08-30 Kurland Kenneth Z Means and method of implanting bioprosthetics
WO1987005489A1 (fr) * 1986-03-17 1987-09-24 Waltap Ltd Valve cardiaque prothetique et instrument de placement et/ou de retrait de ladite valve
WO1988000459A1 (fr) * 1986-07-17 1988-01-28 Quotidian No. 100 Pty. Limited Valvule veineuse prothetique
US5358518A (en) * 1991-06-25 1994-10-25 Sante Camilli Artificial venous valve
US5500014A (en) 1989-05-31 1996-03-19 Baxter International Inc. Biological valvular prothesis

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3988782A (en) * 1973-07-06 1976-11-02 Dardik Irving I Non-antigenic, non-thrombogenic infection-resistant grafts from umbilical cord vessels and process for preparing and using same
US4218782A (en) * 1977-05-25 1980-08-26 Biocoating Anpartsselskab Heart valve prosthesis and method for the production thereof
US4400833A (en) * 1981-06-10 1983-08-30 Kurland Kenneth Z Means and method of implanting bioprosthetics
WO1987005489A1 (fr) * 1986-03-17 1987-09-24 Waltap Ltd Valve cardiaque prothetique et instrument de placement et/ou de retrait de ladite valve
WO1988000459A1 (fr) * 1986-07-17 1988-01-28 Quotidian No. 100 Pty. Limited Valvule veineuse prothetique
US5500014A (en) 1989-05-31 1996-03-19 Baxter International Inc. Biological valvular prothesis
US5358518A (en) * 1991-06-25 1994-10-25 Sante Camilli Artificial venous valve

Cited By (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7267686B2 (en) 1999-10-21 2007-09-11 Boston Scientific Scimed, Inc Implantable prosthetic valve
US7156872B2 (en) 2000-10-26 2007-01-02 Ernst Peter Strecker Implantable valve system
US6602286B1 (en) 2000-10-26 2003-08-05 Ernst Peter Strecker Implantable valve system
WO2002041764A3 (fr) * 2000-10-26 2003-04-24 Boston Scient Corp Systeme de valve implantable
US6752828B2 (en) 2002-04-03 2004-06-22 Scimed Life Systems, Inc. Artificial valve
US7081131B2 (en) 2002-04-03 2006-07-25 Boston Scientific Corporation Artificial valve
WO2003084443A1 (fr) * 2002-04-03 2003-10-16 Scimed Life Systems, Inc. Valvule artificielle
US7244242B2 (en) 2002-12-30 2007-07-17 Boston Scientific Scimed, Inc. Valve treatment catheter and methods
WO2005013857A1 (fr) * 2003-08-05 2005-02-17 Cook Incorporated Valve veineuse implantable
US9301843B2 (en) 2003-12-19 2016-04-05 Boston Scientific Scimed, Inc. Venous valve apparatus, system, and method
US8932349B2 (en) 2004-09-02 2015-01-13 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US9918834B2 (en) 2004-09-02 2018-03-20 Boston Scientific Scimed, Inc. Cardiac valve, system and method
US7566343B2 (en) 2004-09-02 2009-07-28 Boston Scientific Scimed, Inc. Cardiac valve, system, and method
US9622859B2 (en) 2005-02-01 2017-04-18 Boston Scientific Scimed, Inc. Filter system and method
US9370419B2 (en) 2005-02-23 2016-06-21 Boston Scientific Scimed, Inc. Valve apparatus, system and method
US9808341B2 (en) 2005-02-23 2017-11-07 Boston Scientific Scimed Inc. Valve apparatus, system and method
US9861473B2 (en) 2005-04-15 2018-01-09 Boston Scientific Scimed Inc. Valve apparatus, system and method
US9028542B2 (en) 2005-06-10 2015-05-12 Boston Scientific Scimed, Inc. Venous valve, system, and method
US11337812B2 (en) 2005-06-10 2022-05-24 Boston Scientific Scimed, Inc. Venous valve, system and method
US9474609B2 (en) 2005-09-21 2016-10-25 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US7569071B2 (en) 2005-09-21 2009-08-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US10548734B2 (en) 2005-09-21 2020-02-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
US10226344B2 (en) 2007-02-05 2019-03-12 Boston Scientific Scimed, Inc. Percutaneous valve, system and method
US11504239B2 (en) 2007-02-05 2022-11-22 Boston Scientific Scimed, Inc. Percutaneous valve, system and method
US9421083B2 (en) 2007-02-05 2016-08-23 Boston Scientific Scimed Inc. Percutaneous valve, system and method
US10722365B2 (en) 2007-10-17 2020-07-28 Cook Medical Technologies Llc Implantable valve device
US11471568B2 (en) 2007-10-17 2022-10-18 Envveno Medical Corporation Biological valve for venous insufficiency
US12329881B2 (en) 2007-10-17 2025-06-17 Envveno Medical Corporation Biological valve for venous insufficiency
AU2008312361B2 (en) * 2007-10-17 2013-04-18 Cook Medical Technologies Llc Implantable valve device
US12042380B2 (en) 2007-10-17 2024-07-23 Cook Medical Technologies Llc Implantable valve device
US11285243B2 (en) 2007-10-17 2022-03-29 Envveno Medical Corporation Biological valve for venous insufficiency
US11338064B2 (en) 2007-10-17 2022-05-24 Envveno Medical Corporation Biological valve for venous insufficiency
US12029649B2 (en) 2007-10-17 2024-07-09 Cook Medical Technologies Llc Implantable valve device
US11974922B2 (en) 2007-10-17 2024-05-07 Cook Medical Technologies Llc Implantable valve device
WO2009052340A1 (fr) 2007-10-17 2009-04-23 Cook Incorporated Dispositif de valvule implantable
WO2009052207A3 (fr) * 2007-10-17 2010-09-16 Hancock Jaffe Laboratories Valvule biologique pour insuffisance valvulaire veineuse
US11577004B2 (en) 2007-10-17 2023-02-14 Envveno Medical Corporation Biological valve for venous insufficiency
US11717408B2 (en) 2007-10-17 2023-08-08 Cook Medical Technologies Llc Implantable valve device
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
US10940167B2 (en) 2012-02-10 2021-03-09 Cvdevices, Llc Methods and uses of biological tissues for various stent and other medical applications
US11406495B2 (en) 2013-02-11 2022-08-09 Cook Medical Technologies Llc Expandable support frame and medical device
US9744037B2 (en) 2013-03-15 2017-08-29 California Institute Of Technology Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves

Also Published As

Publication number Publication date
EP1187581A1 (fr) 2002-03-20
AU4673700A (en) 2000-11-21

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