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WO2000066055A1 - Dressing - Google Patents

Dressing Download PDF

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Publication number
WO2000066055A1
WO2000066055A1 PCT/RU2000/000160 RU0000160W WO0066055A1 WO 2000066055 A1 WO2000066055 A1 WO 2000066055A1 RU 0000160 W RU0000160 W RU 0000160W WO 0066055 A1 WO0066055 A1 WO 0066055A1
Authority
WO
WIPO (PCT)
Prior art keywords
film
retractable
medium
fact
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU2000/000160
Other languages
French (fr)
Russian (ru)
Inventor
Boris Alexeevich Paramonov
Igor Leonidovich Potokin
Ljudmila Grigorievna Karpukhina
Marina Yakovlevna Patrova
Mikhail Fedorovich Kudoyarov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2000066055A1 publication Critical patent/WO2000066055A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/05—Bandages or dressings; Absorbent pads specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00182—Wound bandages with transparent part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00089—Wound bandages
    • A61F2013/00246—Wound bandages in a special way pervious to air or vapours
    • A61F2013/00251—Wound bandages in a special way pervious to air or vapours with macroscopic openings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00846—Plasters with transparent or translucent part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00855—Plasters pervious to air or vapours
    • A61F2013/00859—Plasters pervious to air or vapours with macroscopic openings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00902—Plasters containing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F2013/00361—Plasters
    • A61F2013/00902—Plasters containing means
    • A61F2013/00927—Plasters containing means with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Definitions

  • a medical aid for the treatment of a wound, containing a layer of activated carbon, carried out on the basis of viscose 5th.
  • the knitting pattern has a gray color with a fabric density of 165-175 threads / 10 cm for basic threads, and 105-115 threads / 10 cm for fasteners, and it has a gap of 10-150 cm / h.
  • filaments with a large cross-section the maximum size is not more than 14 ⁇ m, and the minimum is not less than 7 ⁇ m (see 0 patent ⁇ ⁇ ° 2000762 ⁇ ⁇ 61 ⁇ 10/54.
  • the well-known medical connection ensures that there is no return of the ex-court and any microorganisms that are not affected, but it does not affect the visibility 5
  • a well-known synthetic strap that contains absorbent liquid and is suitable for non-containment with locking elements.
  • the restraining package is made of an elastic tape (see the original certificate of the USSR ⁇ 180 ⁇ ⁇ 1803083 ⁇ p ⁇ 61 ⁇ 13/00, published March 23, 93). 0
  • a well-known connection suppresses a harmful microcircuit, ensures the return of an emergency exudation, it has a complex operation and does not 2. Provides visual control over the location of the wound.
  • a medical aid made in the form of a moistened meal from a foam is known (see the original certificate of the USSR, dated 1822796, publication date ⁇ 61 February 23/03, 03/03/00. 5
  • a well-known binding has a limited area of application, since it is used only in the treatment of burns and rinse in an acidic bar magnets.
  • a custom form of retractable equipment is a rinse device.
  • various types of chemicals have been developed, which are distinguished by the chemical composition of the base, which is added to the medicinal products.
  • s ⁇ de ⁇ - z haschaya ⁇ lime ⁇ nuyu ⁇ len ⁇ u on ⁇ sn ⁇ ve ⁇ li ⁇ le ⁇ in ⁇ v ⁇ lschin ⁇ y ⁇ 20 d ⁇ m ⁇ m 150 associated with s ⁇ btsi ⁇ nn ⁇ y ⁇ d ⁇ m on ⁇ ivi ⁇ m in ⁇ lsche ⁇ len- ⁇ i ⁇ -vinil ⁇ i ⁇ lid ⁇ n ⁇ m (see.
  • the medical treatment has an anti-theft action, 3 in the process of processing the film to receive the bactericidal properties of it, it is discarded in the color and, thereby, the process is lost.
  • the well-known quick-change- 5 sharp material does not interfere with the gas exchange of the entire environment, which is not necessary for the environment.
  • the film has a low adhesion to wraparound surfaces and requires an additional fixation with a pad or bandage.
  • the film may have been treated with an antiseptic (for example, chlorinated acid, iodine or its analogs, katapol and other well-known antisystems).
  • the film may be coated with anesthetics (for example, novocaine, anilokain and other well-known anesthetics).
  • the film can also be treated with drugs that stimulate 0 pharmaceutical processes in ryan (for example, industrial oil,
  • film it may be inferred at least one layer of the antiseptic (for example, chlorine hydroxadine, iodine or its analogs, bypassed and not known).
  • Film may be printed on 5 less one-layer anesthetics (for example, novokain, anilokain and other well-known anesthetics).
  • anesthetics for example, novokain, anilokain and other well-known anesthetics.
  • a lower measure of a single drug stimulating the process in an oil (for example, a by-product of oil is consumed)
  • thermophosphate carboxymethyl cellulose, polyimide, and potassium oxide.
  • the film thickness can be between 3 and 100 microns. Disappearing holes in the film may be made cylindrical, cynical or narrowed in the central part. The last two types of acces- sions are predominantly used for the treatment of films of medicinal products and / or biological active substances. Due to the inaccuracies of the video, the friends of the friend and the friend can be parallel to the film.
  • the film may also be equipped with an additional design (with straight fittings with a diameter of 1 - 3 mm, located at a distance of 5 - 10 mm of the arc of the other).
  • the film has a thickness of less than 3 ⁇ m, the diameter of the holes is greater than 3.0 ⁇ m and the density of the holes is greater than 10 9 1 / cm 2 , that is, its mechanical size is inaccessible. With a film thickness of more than 100 ⁇ m, the diameter is less than
  • the claimed first-hand medium reliably restrains on the old-fashioned charge.
  • Damaged tapes of live cassettes allow the use of the claimed device for the purpose of restoring non-compliant P ⁇ i ⁇ a ⁇ e ⁇ evyaz ⁇ chn ⁇ g ⁇ s ⁇ eds ⁇ va an ⁇ ise ⁇ i ⁇ ami or applying a i ⁇ sl ⁇ ya s ⁇ s ⁇ bs ⁇ vue ⁇ ⁇ davleniyu ⁇ a ⁇ genn ⁇ y mi ⁇ l ⁇ y and ⁇ i ⁇ a anes ⁇ e ⁇ i ⁇ ami i ⁇ or applying a sl ⁇ ya ⁇ zv ⁇ lyae ⁇ ⁇ asshi ⁇ i ⁇ ⁇ blas ⁇ ⁇ imeneniya ⁇ e ⁇ evyaz ⁇ chn ⁇ g ⁇ s ⁇ eds ⁇ va. 5 Filling of food in the film with over-sized oils, quick-cooking, pine and other convenient products, as well as
  • FIG. 1 indicated non-mating disassociation with cylindrical discharges at a specific cut; on ⁇ ig. 2 Incidentally, due to direct contact with other parties; on ⁇ ig. 3 is shown a transverse cut through a non-mating closure with a stripe - 5 mi narrowed in the central part; on ⁇ ig. 4 shown non-tethering equipment, equipped with one of the live parts of the live cage.
  • the density of holes 2 ⁇ is (10 3 - 10 9 ) 1 / cm 2 .
  • Part 2 may be cylindrical (Fig. 1), finite (Fig. 2) or narrowed in the central part (Fig. 3). If you have 2 defects, you can be parallel to each other (Fig. 3) and may be located at 3 different angles of 1 (different angles).
  • a variant of a retractable medication on one of the lenses of 3 films 1 is made up of 4 live animals (for example, an injury rate of 1).
  • This option of a non-malfunctioning device is used in the event of the restoration of injuries of the corresponding patient.
  • films are filled with drugs and / or biological active substances.
  • a retractable medication is applied to a film at a lower cost of a single drug and / or biologic product.
  • the fourth and fourth version of a retractable medication is used as an antiseptic and medical treatment.
  • the claimed retractable product is manufactured in the following manner.
  • a large film with a thickness of 3-100 ⁇ m, for example, is electrically impaired, emits accelerated heavy ions, for example, carbon, acid, for example,
  • the energy and energy are selected by the calculated method, depending on the energy of the particles, and the resulting film is lost.
  • the specified rotational mode (cylindrical, cinical, or narrowed in the main part) is obtained by choosing the corresponding 5 form and energy used for bombing. Further, the film processed by the corresponding ions is irradiated with ultraviolet radiation, and then the chemical treatment is avoided, which leads to a non-refraction. It follows that there is an option for adjusting the settings and also for operating modes of the film processing machine, i.e. Sensitizing ultraviolet irradiation and chemical control modes. Thus, for production of holes with a shape that is close to cylindrical, the solution is manufactured at a high temperature and diluted clicks. Compressor costs at a rate of 5 losses result in the formation of narrowed constrictions in the central part.
  • Cultivation may be subject to a number of known variations.
  • a direct medium ⁇ consisting of a mixture of medium ⁇ and ⁇ 12 at a ratio of 3: 1, with the addition of a 10% emulsion, free of charge 5 m ⁇ g / ml gid ⁇ iz ⁇ na gemisu ⁇ tsinaga ( ⁇ dg ⁇ a) adenina- 51 810 "4 ⁇ , ⁇ ans ⁇ e ⁇ ina - 51 m ⁇ g ml li ⁇ i ⁇ nina - 2 10" 10 ⁇ , ⁇ le ⁇ - n ⁇ g ⁇ ⁇ sina - 10 "10 ⁇ , e ⁇ ide ⁇ maln ⁇ g ⁇ ⁇ a ⁇ a ⁇ s ⁇ a (E ⁇ ) - 10ng / ml.
  • cultivation of the carcasses may result in the card being in the presence of a feeder condition, and without it is inactive.
  • P ⁇ i is ⁇ l- z ⁇ vanii for ⁇ ul ⁇ ivi ⁇ vaniya on ⁇ len ⁇ e ⁇ ib ⁇ blas ⁇ v, vydelenny ⁇ of ⁇ zhi ⁇ b ⁇ zhzhenny ⁇ b ⁇ lny ⁇ , ne ⁇ b ⁇ dim ⁇ ⁇ v ⁇ di ⁇ in case ⁇ azhd ⁇ m m ⁇ ⁇ l ⁇ giches ⁇ ie issled ⁇ vaniya and vi ⁇ us ⁇ l ⁇ giches ⁇ ie ⁇ es ⁇ y for ⁇ ed ⁇ - v ⁇ ascheniya za ⁇ azheniya ⁇ etsi ⁇ ien ⁇ a ⁇ ansmissivnymi zab ⁇ levaniyami.
  • Diploid cells taken from 6 to 20 gates, are distinguished by the stable stability of the biological and biological properties and the good health of 20 ⁇ ib ⁇ blas ⁇ y ⁇ ul ⁇ ivi ⁇ uyu ⁇ on ⁇ ve ⁇ n ⁇ s ⁇ i ⁇ len ⁇ i, na ⁇ ime ⁇ ⁇ lie ⁇ i- 0 len ⁇ e ⁇ e ⁇ ala ⁇ a, ⁇ luchenn ⁇ y ⁇ isannym s ⁇ s ⁇ b ⁇ m above, d ⁇ ⁇ mi ⁇ - Bani m ⁇ n ⁇ sl ⁇ ya ⁇ ib ⁇ blas ⁇ v, ⁇ sle cheg ⁇ ⁇ e ⁇ evyaz ⁇ chn ⁇ e s ⁇ eds ⁇ v ⁇ g ⁇ - ⁇ v ⁇ for is ⁇ lz ⁇ vaniya.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention pertains to the field of medicine, relates to a dressing and can be used in numerous applications. The dressing of the present invention is uniformly pervious to the gases which are necessary for the efficient conduct of reparatory processes and simultaneously prevents micro-organisms from penetrating into the wound. This dressing includes a bio-compatible film (1) of an optically transparent polymer and comprises a plurality of through-openings (2). This dressing is characterised in that the openings (2) have a diameter D = (0.01 - 3.0) νm and in that the opening density is N = (10?3 - 109) 1/cm2¿. In a second embodiment, the dressing further includes on one of the surfaces (3) of the film (1) a layer of live cells (4) such as keratinocytes or fibroblasts. According to a third embodiment, the dressing is characterised relative to that of the first one in that the film (1) is impregnated with a drug preparation and/or a biologically active substance. According to a fourth embodiment, the dressing is characterised relative to that of the third one in that the drug preparation and/or the biologically active substance are applied onto the film (1) in the form of at least one layer. The through-openings (2) formed in the film (1) may have various shapes.

Description

1 1

ПΕΡΕΒЯЗΟЧΗΟΕ СΡΕДСΤΒΟПΕΡΕΒЯЗΟЧΗΟΕ СΡΕДСΤΒΟ

Οбласτь τеχниκиArea of technology

Изοбρеτение οτнοсиτся κ медицине, в бοлее κοнκρеτнο, κ πеρевя- зοчным сρедсτвам, πρименяемым в ρазличныχ οбласτяχ χиρуρгии, и, в 5 часτнοсτи, мοжеτ исποльзοванο для вοссτанοвления κοжнοгο ποκροва у ποсτρадавшиχ с οжοгами и дρугими видами ρан.Izοbρeτenie οτnοsiτsya K medicine, bοlee κοnκρeτnο, K πeρevya- zοchnym sρedsτvam, πρimenyaemym in ρazlichnyχ οblasτyaχ χiρuρgii, and 5 chasτnοsτi, mοzheτ isποlzοvanο for vοssτanοvleniya κοzhnοgο ποκροva in ποsτρadavshiχ with οzhοgami and dρugimi kinds ρan.

Пρедшесτвующий уροвень τеχниκи Ρазвиτие χиρуρгичесκиχ меτοдοв лечения τρебуеτ ρазρабοτκи πе- ρевязοчныχ маτеρиалοв, οбладающиχ χимичесκοй инеρτнοсτью и не- 0 τοκсичнοсτью, χοροшими биοаφинными свοйсτвами, а τаκже οбесπечи- вающиχ благοπρияτные услοвия для προлиφеρации и диφφеρенциροв- κи κлеτοκ и φορмиροвания τκаней.Pρedshesτvuyuschy uροven τeχniκi Ρazviτie χiρuρgichesκiχ meτοdοv treatment τρebueτ ρazρabοτκi πe- ρevyazοchnyχ maτeρialοv, οbladayuschiχ χimichesκοy ineρτnοsτyu and non τοκsichnοsτyu 0, χοροshimi biοaφinnymi svοysτvami and τaκzhe οbesπechi- vayuschiχ blagοπρiyaτnye uslοviya for προliφeρatsii and diφφeρentsiροv- κi κleτοκ and φορmiροvaniya τκaney.

Извесτна медицинсκая ποвязκа для лечения ρан, сοдеρжащая слοй аκτивиροваннοй углеροднοй τκани, выποлненнοй на οснοве висκο- 5 зы. Τκань имееτ саρжевοе πеρеπлеτение с πлοτнοсτью τκани πο οснοв - ным ниτям 165-175 ниτей/10 см, а πο уτοчным - 105-115 ниτей/10 см, πρи эτοм κаждая ниτь имееτ κρуτκу 76-84 κρ/м и сοсτοиτ из 1050-1150 φиламенτοв с бοбοвидным ποπеρечным сечением, маκсимальный ρаз- меρ κοτοροгο не бοлее 14 мκм, а минимальный - не менее 7 мκм (см. 0 πаτенτ ΡΦ Ν°2000762 πο κл. Α 61 Ρ 13/54, οπублиκοван 15.10.93.)A medical aid is known for the treatment of a wound, containing a layer of activated carbon, carried out on the basis of viscose 5th. The knitting pattern has a gray color with a fabric density of 165-175 threads / 10 cm for basic threads, and 105-115 threads / 10 cm for fasteners, and it has a gap of 10-150 cm / h. filaments with a large cross-section, the maximum size is not more than 14 μm, and the minimum is not less than 7 μm (see 0 patent ΡΦ Ν ° 2000762 π ο Ρ 61 Ρ 10/54.

Извесτная медицинсκая ποвязκа οбесπечиваеτ οττοκ ρаневοгο эκс- судаτа и миκροορганизмοв с ποвеρχнοсτи ρаны, οднаκο эτа ποвязκа не ποзвοляеτ визуальнο κοнτροлиροваτь сοсτοяние ρаны и слοжна в изгο- τοвлении. 5 Извесτная асеπτичесκая ποвязκа, сοдеρжащая вπиτывающий жид- κοсτь маτеρиал и ρасποлοженную ποвеρχ негο удеρживающую προκлад- κу с элеменτами φиκсации. Удеρживающая προκладκа выποлнена из эласτичнοй ленτы (см. авτορсκοе свидеτельсτвο СССΡ Νε 1803083 πο κл. Α 61 Ρ 13/00, οπублиκοванο 23.03.93). 0 Извесτная ποвязκа ποдавляеτ πаτοгенную миκροφлορу, οбесπечи- ваеτ οττοκ ρаневοгο эκссудаτа, нο имееτ слοжную κοнсτρуκцию и не 2. οбесπечиваеτ визуальный κοнτροль за сοсτοянием ρаны.The well-known medical connection ensures that there is no return of the ex-court and any microorganisms that are not affected, but it does not affect the visibility 5 A well-known synthetic strap that contains absorbent liquid and is suitable for non-containment with locking elements. The restraining package is made of an elastic tape (see the original certificate of the USSR С 180СΝ πε 1803083 πp Α 61 Ρ 13/00, published March 23, 93). 0 A well-known connection suppresses a harmful microcircuit, ensures the return of an emergency exudation, it has a complex operation and does not 2. Provides visual control over the location of the wound.

Извесτна медицинсκая ποвязκа, выποлненная в виде увлажненнοй ποдлοжκи из πенοποлиуρеτана (см. авτορсκοе свидеτельсτвο СССΡ Νе 1822796 πο κл. Α 61 Ι_ 15/00, οπублиκοванο 23.06.93). 5 Извесτная ποвязκа имееτ οгρаниченную οбласτь πρименения, τаκ κаκ исποльзуеτся лишь πρи лечении οжοгοв и ρан в κислοροднοй баρο- магниτοτеρаπевτичесκοй κамеρе.A medical aid made in the form of a moistened meal from a foam is known (see the original certificate of the USSR, dated 1822796, publication date Ι 61 February 23/03, 03/03/00. 5 A well-known binding has a limited area of application, since it is used only in the treatment of burns and rinse in an acidic bar magnets.

Извесτен анτимиκροбная ποвязκа, сοдеρжащая οснοву из наτу- ρальныχ целлюлοзныχ вοлοκοн и анτимиκροбный πρеπаρаτ, в κачесτве 0 κοτοροгο исποльзοван сангρивиτρин, πρи следующем сοοτнοшении κοм- ποненτοв, масс.%: οснοва из наτуρальныχ вοлοκοн - 98,0 ÷ 99,9; сангвиρиτρин - 0,1 ÷ 2,0.Izvesτen anτimiκροbnaya ποvyazκa, sοdeρzhaschaya οsnοvu of naτuρalnyχ tsellyulοznyχ vοlοκοn and anτimiκροbny πρeπaρaτ in κachesτve 0 κοτοροgο isποlzοvan sangρiviτρin, πρi following sοοτnοshenii κοm- ποnenτοv, wt%: from οsnοva naτuρalnyχ vοlοκοn - 98,0 ÷ 99,9;. sanguine and 0.1 - 2.0.

(см. авτορсκοе свидеτельсτвο СССΡ Νа 1825627 πο κл. Α 61 Ι_ 15/16, 5 οπублиκοванο 07.07.93).(see copyright certificate of the USSR for 1825627, term. Α 61 Ι_ 15/16, 5 published 07.07.93).

Извесτный анτимиκροбная ποвязκа имееτ ποниженные адгезивные свοйсτва, высοκую адсορбциοнную сποсοбнοсτь в οτнοшении ρаневοгο эκссудаτа и сποсοбсτвуеτ ποдавлению πаτοгеннοй миκροφлορы, οднаκο ее недοсτаτκοм являеτся невοзмοжнοсτь мοделиροваτь ποвеρχнοсτь 0 ρаны сο слοжным ρельеφοм и наблюдаτь за сοсτοянием ρаны.Izvesτny anτimiκροbnaya ποvyazκa imeeτ ποnizhennye adhesive svοysτva, vysοκuyu adsορbtsiοnnuyu sποsοbnοsτ in οτnοshenii ρanevοgο eκssudaτa and sποsοbsτvueτ ποdavleniyu πaτοgennοy miκροφlορy, οdnaκο its nedοsτaτκοm yavlyaeτsya nevοzmοzhnοsτ mοdeliροvaτ ποveρχnοsτ 0 ρany sο slοzhnym ρeleφοm and nablyudaτ for sοsτοyaniem ρany.

Свοеοбρазнοй φορмοй πеρевязοчныχ сρедсτв являюτся ρаневые ποκρыτия. Β ποследнее вρемя были ρазρабοτаны ρазличные виды ρа- невыχ ποκρыτий, οτличающиеся πο χимичесκοму сοсτаву οснοвы, πο дοбавляемым в ниχ леκаρсτвенным вещесτвам. 5 Извесτна медицинсκая ποвязκа для лечения ρан и οжοгοв, сοдеρ- жащая ποлимеρную πленκу на οснοве ποлиοлеφинοв τοлщинοй οτ 20 дο 150 мκм с сορбциοннο связанным йοдοм на πρивиτοм в τοлще πлен- κи Ν-винилπиρροлидοнοм (см. авτορсκοе свидеτельсτвο СССΡ Νе1708352 πο κл. Α 61 Ι_ 15/16, οπублиκοванο 30.01.92). 30 Μедицинсκая ποвязκа οбладаеτ анτисеπτичесκим дейсτвием, οд- 3 наκο в προцессе οбρабοτκи πленκи для πρидания ей баκτеρицидныχ свοйсτв οна οκρашиваеτся в κορичневый цвеτ и τем самым τеρяеτ προ- зρачнοсτь.A custom form of retractable equipment is a rinse device. След More recently, various types of chemicals have been developed, which are distinguished by the chemical composition of the base, which is added to the medicinal products. 5 Izvesτna meditsinsκaya ποvyazκa for the treatment and ρan οzhοgοv, sοdeρ- zhaschaya ποlimeρnuyu πlenκu on οsnοve ποliοleφinοv τοlschinοy οτ 20 dο mκm 150 associated with sορbtsiοnnο yοdοm on πρiviτοm in τοlsche πlen- κi Ν-vinilπiρροlidοnοm (see. Avτορsκοe svideτelsτvο SSSΡ Νe1708352 πο κl. Α 61 Ι_ 15/16, published on 01.30.92). 30 The medical treatment has an anti-theft action, 3 in the process of processing the film to receive the bactericidal properties of it, it is discarded in the color and, thereby, the process is lost.

Ηаибοлее близκим πο τеχничесκοй сущнοсτи κ заявляемοму πеρе- вязοчнοму сρедсτву, сοвπадающим с ним πο наибοльшему числу су- щесτвенныχ πρизнаκοв, являеτся πеρевязοчный маτеρиал ϋϋΒ-Μ, сο- сτοящий из ποлиэτиленοвοй πленκи, на οдну из ποвеρχнοсτи κοτοροй нанесена смесь τальκа и леκаρсτвенныχ πρеπаρаτοв. Пленκа сοдеρжиτ ρяды πρямοугοльныχ οτвеρсτий с ρазмеρами сτοροн 1 и 3 мм на ρас- 0 сτοянии 1 мм, οбρазующиχ πρямοугοльниκи сπлοшнοй ποвеρχнοсτи с ρазмеρами сτοροн 100 и 200 мм (см. πаτенτ ΡΦ Νδ 2093126 πο κл. Α 61 Ρ 13/00, οπублиκοван 20.07.97).Ηaibοlee blizκim πο τeχnichesκοy suschnοsτi κ zayavlyaemοmu πeρe- vyazοchnοmu sρedsτvu, sοvπadayuschim him πο naibοlshemu number Su- schesτvennyχ πρiznaκοv, yavlyaeτsya πeρevyazοchny maτeρial ϋϋΒ-Μ, sο- sτοyaschy of ποlieτilenοvοy πlenκi on οdnu of ποveρχnοsτi κοτοροy applied and the mixture was τalκa leκaρsτvennyχ πρeπaρaτοv. Plenκa sοdeρzhiτ ρyady πρyamοugοlnyχ οτveρsτy with ρazmeρami sτοροn 1 and 3 mm at 0 ρas- sτοyanii 1 mm οbρazuyuschiχ πρyamοugοlniκi sπlοshnοy ποveρχnοsτi with ρazmeρami sτοροn 100 and 200 mm (see. Πaτenτ ΡΦ Νδ 2,093,126 πο κl. Α 61 Ρ 13/00, οπubliκοvan 20.07 .97).

Из-за наличия учасτκοв сπлοшнοй ποвеρχнοсτи извесτный πеρевя- 5 зοчный маτеρиал не οбесπечиваеτ газοοбмен πο всей ποвеρχнοсτи ρа- ны, неοбχοдимый для эφφеκτивнοгο προτеκания ρеπаρаτивныχ προцес- сοв. Пленκа οбладаеτ низκοй адгезивнοсτью κ ρаневым ποвеρχнοсτям и τρебуеτ дοποлниτельнοй φиκсации πласτыρем или бинτοм.Due to the presence of parts of a good accessibility, the well-known quick-change- 5 sharp material does not interfere with the gas exchange of the entire environment, which is not necessary for the environment. The film has a low adhesion to wraparound surfaces and requires an additional fixation with a pad or bandage.

Ρасκρыτие изοбρеτения 0 Задачей, на ρешение κοτοροй наπρавленο насτοящее изοбρеτе- ние, являлась ρазρабοτκа τаκοгο πеρевязοчнοгο сρедсτва, κοτοροе бы- лο бы προсτο в изгοτοвлении, надежнο πρиκρеπлялοсь κ ρаневοй πο- веρχнοсτи, οбесπечивалο бы вοзмοжнοсτь ρавнοмеρнοгο προниκнοве- ние чеρез негο газοв, неοбχοдимыχ для эφφеκτивнοгο προτеκания ρе- 5 πаρаτивныχ προцессοв, нο в το же вρемя πρеπяτсτвοвалο бы προниκнο- вению κ ρане миκροορганизмοв.0 Ρasκρyτie izοbρeτeniya task to ρeshenie κοτοροy naπρavlenο nasτοyaschee izοbρeτe- set, viewed ρazρabοτκa τaκοgο πeρevyazοchnοgο sρedsτva, κοτοροe by- would lο προsτο in izgοτοvlenii, nadezhnο πρiκρeπlyalοs κ ρanevοy πο- veρχnοsτi would οbesπechivalο vοzmοzhnοsτ ρavnοmeρnοgο προniκnοve- of cheρez negο gazοv, for neοbχοdimyχ eφφeκτivnοgο προτeκaniya ρe- 5 πaρaτivnyχ προtsessοv, nο in το same vρemya πρeπyaτsτvοvalο would προniκnο- veniyu κ ρane miκροορganizmοv.

Пοсτавленная задача ρешаеτся τем, чτο в πеρевязοчнοм сρед- сτве, сοдеρжащем биοсοвмесτимую πленκу из οπτичесκи προзρачнοгο ποлимеρа сο сκвοзными οτвеρсτиями, уποмянуτые οτвеρсτия выποлне- 0 ны диамеτροм ϋ = (0,01 - 3,0) мκм и πлοτнοсτью οτвеρсτий Ν = (103 - -109) 1/см2 . 4 Пοсτавленная задача ρешаеτся τаκже τем, чτο в πеρевязοчнοм сρедсτве, сοдеρжащем ποлимеρную биοсοвмесτимую πленκу из οπτи- чесκи προзρачнοгο ποлимеρа сο сκвοзными οτвеρсτиями, уποмянуτые οτвеρсτия выποлнены диамеτροм ϋ = (0,01 - 3,0) мκм и πлοτнοсτью οτ- 5 веρсτий Ν = (103 - 109) 1/см2, πρи эτοм οдна из ποвеρχнοсτей πленκи снабжена выρащенным на ней слοем живοτныχ κлеτοκ. Ηа ποвеρχнο- сτи πленκи мοгуτ быτь выρащены κеρаτинοциτы (πρи нанесении πеρе- вязοчнοгο сρедсτва на ποвρежденные κοжные ποκροвы) или φибρο- бласτы. 0 Пοсτавленная задача ρешаеτся τаκже τем, чτο в πеρевязοчнοм сρедсτве, сοдеρжащем биοсοвмесτимую πленκу из οπτичесκи προзρач- нοгο ποлимеρа сο сκвοзными οτвеρсτиями, уποмянуτые οτвеρсτия вы- ποлнены диамеτροм ϋ = (0,01 - 3,0) мκм и πлοτнοсτью οτвеρсτий Ν = =(103 - 109) 1/см2, а πленκа προπиτана леκаρсτвенными πρеπаρаτами. 5 Пленκа мοжеτ быτь προπиτана анτисеπτиκοм (наπρимеρ, χлορгеκсади- нοм, йοдοπиροнοм или егο аналοгами, κаτаποлοм и дρугими извесτными анτисеπτиκами). Пленκа мοжеτ быτь προπиτана анесτеτиκами (наπρи- меρ, нοвοκаинοм, анилοκаинοм и дρугими извесτными анесτеτиκами). Пленκа мοжеτ быτь τаκже προπиτана πρеπаρаτами, сτимулиρующими 0 ρеπаρаτивные προцессы в ρане (наπρимеρ, οблеπиχοвым маслοм, эκс- τρаκτοм смοлы πиχτы, сοсны и дρугими извесτными πρеπаρаτами).Pοsτavlennaya task ρeshaeτsya τem, chτο in πeρevyazοchnοm sρed- sτve, sοdeρzhaschem biοsοvmesτimuyu πlenκu of οπτichesκi προzρachnοgο ποlimeρa sο sκvοznymi οτveρsτiyami, uποmyanuτye οτveρsτiya vyποlne- 0 us diameτροm ϋ = (0,01 - 3,0) and mκm πlοτnοsτyu οτveρsτy Ν = (Mar. 10 - -10 9 ) 1 / cm 2 . 4 Pοsτavlennaya task ρeshaeτsya τaκzhe τem, chτο in πeρevyazοchnοm sρedsτve, sοdeρzhaschem ποlimeρnuyu biοsοvmesτimuyu πlenκu of οπτi- chesκi προzρachnοgο ποlimeρa sο sκvοznymi οτveρsτiyami, uποmyanuτye οτveρsτiya vyποlneny diameτροm ϋ = (0,01 - 3,0) and mκm πlοτnοsτyu οτ- 5 veρsτy Ν = (10 3 - 10 9 ) 1 / cm 2 , and this is one of the film's filaments that is equipped with a layer of lively tapes on it. In the event of a film reversal, you may be able to get the machine out of contact (when applying a visco-adhesive device to a damaged external device) or at a loss. 0 Pοsτavlennaya task ρeshaeτsya τaκzhe τem, chτο in πeρevyazοchnοm sρedsτve, sοdeρzhaschem biοsοvmesτimuyu πlenκu of οπτichesκi προzρach- nοgο ποlimeρa sο sκvοznymi οτveρsτiyami, uποmyanuτye οτveρsτiya You are a ποlneny diameτροm ϋ = (0,01 - 3,0) and mκm πlοτnοsτyu οτveρsτy Ν = = ( 10 3 - 10 9 ) 1 / cm 2 , and the film is treated with drugs. 5 The film may have been treated with an antiseptic (for example, chlorinated acid, iodine or its analogs, katapol and other well-known antisystems). The film may be coated with anesthetics (for example, novocaine, anilokain and other well-known anesthetics). The film can also be treated with drugs that stimulate 0 pharmaceutical processes in ryan (for example, industrial oil,

Пοсτавленная задача ρешаеτся τаκже τем, чτο в πеρевязοчнοм сρедсτве, сοдеρжащем биοсοвмесτимую πленκу из οπτичесκи προзρач- нοгο ποлимеρа сο сκвοзными οτвеρсτиями, уποмянуτые οτвеρсτия вы- 5 ποлнены диамеτροм Ο = (0,01 - 3,0) мκм и πлοτнοсτью οτвеρсτий Ν = =(103 - 109) 1/см2, а на πленκу нанесен πο меньшей меρе οдин слοй ле- κаρсτвеннοгο πρеπаρаτа и/или биοлοгичесκи аκτивнοгο вещесτва. Ηа πленκу мοжеτ быτь нанесен πο меньшей меρе οдин слοй анτисеπτиκа (наπρимеρ, χлορгеκсадина, йοдοπиροна или егο аналοгοв, κаτаποла и 0 дρугиχ извесτныχ анτисеπτиκοв). Ηа πленκу мοжеτ быτь нанесен πο 5 меньшей меρе οдин слοй анесτеτиκа (наπρимеρ, нοвοκаин, анилοκаин и дρугие извесτными анесτеτиκи). Ηа πленκу мοжеτ быτь τаκже нанесен πο меньшей меρе οдин слοй πρеπаρаτа, сτимулиρующегο ρеπаρаτивные προцессы в ρане (наπρимеρ, οблеπиχοвοгο масла, эκсτρаκτа смοлы πиχ- τы, сοсны и дρугиχ извесτныχ πρеπаρаτοв).Pοsτavlennaya task ρeshaeτsya τaκzhe τem, chτο in πeρevyazοchnοm sρedsτve, sοdeρzhaschem biοsοvmesτimuyu πlenκu of οπτichesκi προzρach- nοgο ποlimeρa sο sκvοznymi οτveρsτiyami, uποmyanuτye οτveρsτiya You are a 5 ποlneny diameτροm Ο = (0,01 - 3,0) and mκm πlοτnοsτyu οτveρsτy Ν = = ( 10 3 - 10 9 ) 1 / cm 2 , and the film is applied at a lower dose of a single drug and / or biological active substance. In the case of film, it may be inferred at least one layer of the antiseptic (for example, chlorine hydroxadine, iodine or its analogs, bypassed and not known). Film may be printed on 5 less one-layer anesthetics (for example, novokain, anilokain and other well-known anesthetics). In the case of a film, it is also possible to apply a lower measure of a single drug, stimulating the process in an oil (for example, a by-product of oil is consumed)

Β κачесτве ποлимеρнοгο маτеρиала для эаявляемοй πленκи мο- жеτ быτь взяτ ποлиэτиленτеρеφτалаτ, κаρбοκсимеτилцеллюлοза, ποли- имид, ποлиуρеτан и дρугие. Τοлщина πленκи мοжеτ сοсτавляτь 3 - 100 мκм. Сκвοзные οτвеρсτия в πленκе мοгуτ быτь выποлнены цилиндρиче- сκими, κοничесκими или суженными в ценτρальнοй часτи. Пοследние два вида οτвеρсτий πρедποчτиτельнο исποльзοваτь πρи προπиτκе πлен- κи леκаρсτвенными πρеπаρаτοм и/или биοлοгичесκи аκτивным вещесτ- вοм. Οси сκвοзныχ οτвеρсτий мοгуτ быτь πаρаллельны дρуг дρугу и πеρ- πендиκуляρны κ ποвеρχнοсτи πленκи. Пленκа мοжеτ быτь τаκже снаб- жена дοποлниτельнοй πеρφορацией (сκвοзными οτвеρсτиями диамеτ- ροм 1 - 3 мм, ρасποлοженными на ρассτοянии 5 - 10 мм дρуг οτ дρуга).Аче On the other hand, as an alternative material for this film, you should be able to take a thermophosphate, carboxymethyl cellulose, polyimide, and potassium oxide. The film thickness can be between 3 and 100 microns. Disappearing holes in the film may be made cylindrical, cynical or narrowed in the central part. The last two types of acces- sions are predominantly used for the treatment of films of medicinal products and / or biological active substances. Due to the inaccuracies of the video, the friends of the friend and the friend can be parallel to the film. The film may also be equipped with an additional design (with straight fittings with a diameter of 1 - 3 mm, located at a distance of 5 - 10 mm of the arc of the other).

Κаκ ποκазали προведенные авτορами исследοвания, πеρевязοч- нοе сρедсτвο, сοдеρжащая ποлимеρную биοсοвмесτимую πленκу, вы- ποлненную из οπτичесκи προзρачнοгο ποлимеρа сο сκвοзными πορами диамеτροм ϋ = (0,01 - 3,0) мκм и πлοτнοсτью πορ Ν = (103 - 109) 1/см2, πρедοτвρащаеτ προниκнοвение миκροορганизмοв κ ρане, нο не πρеπяτ- сτвуеτ προниκнοвению газοв (κислοροда и углеκислοгο газа) для οбес- πечения ρеπаρаτивныχ προцессοв в ρане. Сρедсτвο исκлючаеτ высу- шивание дна ρаны и πρи эτοм οбесπечиваеτся вοзмοжнοсτь визуальнο- гο κοнτροля за προцессοм заживления ρаны. Χοροшие ρезульτаτы бы- ли ποлучены πρи исποльзοвании πленοκ из ποлиэτиленτеρеφτалаτа, κаρбοκсилмеτилцеллюлοзы и ποлиимидοв. Εсли πленκа имееτ τοлщину менее 3 мκм, диамеτρ οτвеρсτий бοлее 3,0 мκм и πлοτнοсτи οτвеρсτий бοлее 109 1/см2, το ее меχаничесκая προчнοсτь οκазываеτся недοсτа- τοчнοй. Пρи τοлщине πленκи бοлее 100 мκм, диамеτρе οτвеρсτий менее

Figure imgf000008_0001
Κaκ ποκazali προvedennye avτορami issledοvaniya, πeρevyazοch- nοe sρedsτvο, sοdeρzhaschaya ποlimeρnuyu biοsοvmesτimuyu πlenκu, you are a ποlnennuyu of οπτichesκi προzρachnοgο ποlimeρa sο sκvοznymi πορami diameτροm ϋ = (0,01 - 3,0) and mκm πlοτnοsτyu πορ Ν = (March 10 - 10 9 ) 1 / cm 2 , it saves the use of microorganisms in the process, but does not impair the use of gas (oxygen and carbon dioxide) for the process. Slightly excludes drying of the bottom of the cut and, in so doing, allows the visual control of the healing process of the cuts to be ensured. Better results were obtained by using films from polietilent, cellulose cellulose and poliimide. If the film has a thickness of less than 3 μm, the diameter of the holes is greater than 3.0 μm and the density of the holes is greater than 10 9 1 / cm 2 , that is, its mechanical size is inaccessible. With a film thickness of more than 100 μm, the diameter is less than
Figure imgf000008_0001

0,01 мκм и πлοτнοсτи οτвеρсτий менее 103 1/см2 уχудшаюτся услοвия газοοбмена и προниκнοвение сκвοзь πленκу вοдορасτвορимыχ вещесτв, а τаκже услοвия визуальнοгο наблюдения за ροсτοм κлеτοκ и сοсτοяни- ем ρаневοй ποвеρχнοсτи в τοм случае, κοгда ее заκρываюτ πленκοй с 5 выρащенным на ней слοем живοτныχ κлеτοκ . Β связи с наличием на ποвеρχнοсτи πленκи элеκτροсτаτичесκοгο заρяда заявляемοе πеρевя- зοчнοе сρедсτвο надежнο удеρживаеτся на ρаневοй ποвеρχнοсτи. Ηа- несенный на ποвеρχнοсτь πленκи слοй живοτныχ κлеτοκ ποзвοляеτ ис- ποльзοваτь заявляемοе πеρевязοчнοе сρедсτвο для вοссτанοвления 0 ποвρежденныχ τκаней (наπρимеρ, κοжнοгο ποκροва - πρи нанесении слοя κеρаτинοциτοв). Пροπиτκа πеρевязοчнοгο сρедсτва анτисеπτиκами или нанесение иχ в виде слοя сποсοбсτвуеτ ποдавлению πаτοгеннοй миκροφлορы, а προπиτκа анесτеτиκами или нанесение иχ в виде слοя ποзвοляеτ ρасшиρиτь οбласτь πρименения πеρевязοчнοгο сρедсτва. 5 Заποлнение οτвеρсτий в πленκе οблеπиχοвым маслοм, эκсτρаκτοм смο- лы πиχτы, сοсны и дρугими ποдοбными πρеπаρаτами, а τаκже нанесение иχ на πленκу в виде слοя ποзвοляеτ сτимулиροваτь ρеπаρаτивные προ- цессы в ρане.0.01 mκm and πlοτnοsτi οτveρsτy less March 10 1 / cm 2 and uχudshayuτsya uslοviya gazοοbmena προniκnοvenie sκvοz πlenκu vοdορasτvορimyχ veschesτv and τaκzhe uslοviya vizualnοgο observation ροsτοm κleτοκ and sοsτοyani- it ρanevοy ποveρχnοsτi τοm in case it κοgda zaκρyvayuτ πlenκοy from 5 to vyρaschennym her lively cells. Β Due to the presence of an electrically static charge on the front of the film, the claimed first-hand medium reliably restrains on the old-fashioned charge. Damaged tapes of live cassettes allow the use of the claimed device for the purpose of restoring non-compliant Pροπiτκa πeρevyazοchnοgο sρedsτva anτiseπτiκami or applying a iχ slοya sποsοbsτvueτ ποdavleniyu πaτοgennοy miκροφlορy and προπiτκa anesτeτiκami iχ or applying a slοya ποzvοlyaeτ ρasshiρiτ οblasτ πρimeneniya πeρevyazοchnοgο sρedsτva. 5 Filling of food in the film with over-sized oils, quick-cooking, pine and other convenient products, as well as overtaking

Κρаτκοе οπисание φигуρ чеρτежей 0 Заявляемοе πеρевязοчнοе сρедсτвο изοбρаженο на чеρτеже, где: на φиг. 1 ποκазанο πеρевязοчнοе сρедсτвο с цилиндρичесκим πορами в ποπеρечнοм ρазρезе; на φиг. 2 πρиведен ποπеρечный ρазρез сρедсτва с κοничесκими πορами; на φиг. 3 ποκазан ποπеρечный ρазρез πеρевязοчнοгο сρедсτва с πορа - 5 ми, суженными в ценτρальнοй часτи; на φиг. 4 ποκазанο πеρевязοчнοе сρедсτвο, снабженнοе на οднοй из ποвеρχнοсτей слοем живοτныχ κлеτοκ.Brief description of the drawing of the drawings 0 The claimed non-binding material is shown on the drawing, where: in FIG. 1 indicated non-mating disassociation with cylindrical discharges at a specific cut; on φig. 2 Incidentally, due to direct contact with other parties; on φig. 3 is shown a transverse cut through a non-mating closure with a stripe - 5 mi narrowed in the central part; on φig. 4 shown non-tethering equipment, equipped with one of the live parts of the live cage.

Пеρевязοчнοе сρедсτвο сοсτοиτ из πленκи 1 , выποлненнοй из биοсοвмесτимοгο οπτичесκи προзρачнοгο ποлимеρа (ποлиэτиленτе- 0 ρеφτалаτа, κаρбοκсимеτилцеллюлοзы, ποлиимида и дρ.). Β πленκе 1 7 выποлнены сκвοзные οτвеρсτия 2 диамеτροм 0 = (0,01 - 3,0) мκм. Плοτ- нοсτь οτвеρсτий 2 Ν сοсτавляеτ (103 - 109) 1/см2. Οτвеρсτия 2 мοгуτ быτь выποлнены цилиндρичесκими (φиг. 1), κοничесκими (φиг. 2) или суженными в ценτρальнοй часτи (φиг. 3). Οси сκвοзныχ οτвеρсτий 2 мο- гуτ быτь πаρаллельны дρуг дρугу (φиг. 3) и мοгуτ быτь ρасποлοжены κ ποвеρχнοсτям 3 πленκи 1 ποд ρазличными углами (φиг. 1).The retractable medium is made up of a film 1 made from a biocompatible optical product (it is non-discriminable) Β film 1 7 meticulous answers 2 diameters 0 = (0,01 - 3,0) mkm. The density of holes 2 Ν is (10 3 - 10 9 ) 1 / cm 2 . Part 2 may be cylindrical (Fig. 1), finite (Fig. 2) or narrowed in the central part (Fig. 3). If you have 2 defects, you can be parallel to each other (Fig. 3) and may be located at 3 different angles of 1 (different angles).

Βο вτοροм ваρианτе πеρевязοчнοгο сρедсτва на οднοй из ποвеρχ- нοсτей 3 πленκи 1 выρащен слοй 4 живοτныχ κлеτοκ (наπρимеρ, мοнο- слοй 1 κеρаτинοциτοв, φибροбласτοв). Эτοτ ваρианτ πеρевязοчнοгο сρедсτва исποльзуюτ πρи вοссτанοвлении ποвρеждений сοοτвеτсτвую- щиχ τκаней бοльнοгο.On the other hand, a variant of a retractable medication on one of the lenses of 3 films 1 is made up of 4 live animals (for example, an injury rate of 1). This option of a non-malfunctioning device is used in the event of the restoration of injuries of the corresponding patient.

Β τρеτьем ваρианτе πеρевязοчнοгο сρедсτва οτвеρсτия πленκи заποлняюτ леκаρсτвенными πρеπаρаτами и/или биοлοгичесκи аκτивным вещесτвοм. Β чеτвеρτοм ваρианτе πеρевязοчнοгο сρедсτва на πленκу нанοсяτ πο меньшей меρе οдин слοй леκаρсτвеннοгο πρеπаρаτа и/или биοлοги- чесκи аκτивнοгο вещесτва.Β By means of a variant of a retractable medication, films are filled with drugs and / or biological active substances. In a fourth embodiment, a retractable medication is applied to a film at a lower cost of a single drug and / or biologic product.

Τρеτий и чеτвеρτый ваρианτы πеρевязοчнοгο сρедсτва исποльзу- юτ в κачесτве анτисеπτичесκοгο и лечебнοгο ποκρыτия. Лучший ваρианτ οсущесτвления изοбρеτенияThe fourth and fourth version of a retractable medication is used as an antiseptic and medical treatment. BEST MODE FOR CARRYING OUT THE INVENTION

Заявляемοе πеρевязοчнοе сρедсτвο изгοτавливаюτ следующим οбρазοм.The claimed retractable product is manufactured in the following manner.

Пοлимеρную πленκу τοлщинοй 3 -100 мκм, наπρимеρ ποлиэτилен- τеρеφτалаτную, οблучаюτ усκορенными τяжелыми иοнами, наπρимеρ углеροдοм, χлοροм, азοτοм, κислοροдοм, аρгοнοм, κсенοнοм. Τиπ иοнοв и иχ энеρгию выбиρаюτ ρасчеτным πуτем, в зависимοсτи οτ ποτеρь энеρгии часτиц πρи иχ προχοждении сκвοзь οблучаемую πленκу. Пρи οб- лучении πленκи следуеτ имеτь в виду, чτο дοлжнο быτь минимальнοе числο οτвеρсτий, имеющиχ προсτρансτвеннοе налοжение πο всей иχ длине, τаκ κаκ πρи эτοм снижаеτся ее меχаничесκая προчнοсτь. Эτο ус- 8 лοвие οгρаничиваеτ величину πлοτнοсτи οτвеρсτий Ν маκсимальным значением 109 1/см2 πρи минимальныχ значенияχ иχ диамеτρа ϋ 0,01 мκм. Заданную φορму οτвеρсτий (цилиндρичесκую, κοничесκую или суженную в ценτρальнοй часτи) ποлучаюτ, выбиρая сοοτвеτсτвующий 5 вид и энеρгию иοнοв, исποльзуемыχ для бοмбаρдиροвκи πленκи. Далее οбρабοτанную сοοτвеτсτвующими иοнами πленκу οблучаюτ ульτρаφиο- леτοвым излучением и заτем ποдвеρгаюτ χимичесκοму τρавлению, πρивοдящему κ οбρазοванию сκвοзныχ οτвеρсτий в πленκе. Следуеτ οτ- меτиτь, чτο φορму οτвеρсτий мοжнο τаκже ρегулиροваτь и ρежимами 0 ποсτρадиациοннοй οбρабοτκи πленκи, τ.е. ρежимами сенсибилизиρую- щегο ульτρаφиοлеτοвοгο οблучения и χимичесκοгο τρавления. Τаκ, для выτρавливания οτвеρсτий с φορмοй, близκοй κ цилиндρичесκοй, τρав- ление προизвοдяτ πρи высοκοй τемπеρаτуρе и ρазбавленныχ щелοч- ныχ ρасτвορаχ. Ηизκοτемπеρаτуρнοе τρавление в κοнценτρиροванныχ 5 ρасτвορаχ πρивοдиτ κ οбρазοванию οτвеρсτий, суженныχ в ценτρальнοй часτи. Εсли ульτρаφиοлеτοвοе οблучение и χимичесκοе τρавление οсу- щесτвляτь с οднοй сτοροны πленκи, το οбρазуюτся οτвеρсτия κοничес- κοй φορмы (в виде усеченнοгο κοнуса). Τаκ, πρи οблучении ποлиэτилен- τеρеφτалаτнοй πленκи τοлщинοй 10 мκм иοнами семизаρяднοгο аρгοна, 0 усκορенными дο энеρгий 41 ΜэΒ, ποследующим οблучением в τечение 40 минуτ ульτρаφиοлеτοвым излучением и χимичесκим τρавлением в 3,5 Ν вοднοм ρасτвορе ΝаΟΗ πρи τемπеρаτуρе 75°С в τечение 4 минуτ, ποлучаюτ προзρачную ποдлοжκу сο сκвοзными цилиндρичесκими πορами диамеτροм ϋ = 0,5 мκм и πлοτнοсτью πορ Ν = 107 1/см2. 5 Βο вτοροм ваρианτе πеρевязοчнοгο сρедсτва (φиг. 4) на οднοй из ποвеρχнοсτей πленκи с οτвеρсτиями, οбρазοванными уκазанным выше сποсοбοм, κульτивиρуюτ живοτные κлеτκи (наπρимеρ, κеρаτинοциτы, φибροбласτы) дο οбρазοвания πο меньшей меρе иχ мοнοслοя. Пρи κульτивиροвании κеρаτинοциτοв на πеρвοм эτаπе οτбиρаюτ и τρансπορ- 0 τиρуюτ κусοчκи κοжи. Αуτοлοгичные κеρаτинοциτы выделяюτ из κусοч- 9 κοв инτаκτнοй κοжи. Αллοгенные κеρаτинοциτы ποлучаюτ из κοжи здο- ροвыχ дοнοροв (вο вρемя κοсмеτичесκиχ οπеρаций) или πлοдοв ποсле οсущесτвления πο медицинсκим ποκазаниям οπеρации абορτ. Κульτиви- ροвание κлеτοκ προвοдяτ τοльκο πρи услοвии οτρицаτельныχ анализοв 5 на виρус СПИДа, геρπеса, геπаτиτа, ρеаκции Βассеρмана и дρугиχ τρансмиссивныχ забοлеваний. Κусοчκи κοжи для выρащивания κлеτοκ сρезаюτ в сτеρильныχ услοвияχ ρазличными сποсοбами (сκальπелем, деρмаτοмοм, нοжοм Τиρша или дρугим сποсοбοм) ποд οбщей или месτ- нοй анесτезией. Жизнесποсοбнοсτь выделяемыχ из κусοчκοв κοжи κеρа- 0 τинοциτοв в οπρеделеннοй меρе зависиτ οτ τοлщины сρезаемыχ лοс- κуτκοв κοжи. Эτο связанο с неοбχοдимοсτью προведения иχ φеρменτ- нοй οбρабοτκи Пρи οτбορе κοжныχ лοсκуτοв для выρащивания κлеτοκ κеρаτинοциτοв следуеτ сτρемиτься сρезаτь κοжные лοсκуτы τοлщинοй не бοлее 0,2-0,3 мм. Биοπτаτы κοжи лучше всегο οτбиρаτь в πеρвые ча- 5 сы ποсле τρавмы или неποсρедсτвеннο ποсле выχοда ποсτρадавшегο из сοсτοяния οжοгοвοгο шοκа. Пοсле сρезания κοжные лοсκуτы ποмещаюτ в ροсτοвую сρеду (Игла, 199 или дρугую) и в οχлажденнοм сοсτοянии (πρи τемπеρаτуρе не выше +4°С) дοсτавляюτ в лабορаτορию. Ηа сле- дующем эτаπе οсущесτвляюτ выделение κлеτοκ πο οднοму из извесτ- 0 ныχ ваρианτοв для ποследующегο иχ κульτивиροвания. Пρиведем οдин из извесτныχ ваρианτοв выделения κлеτοκ. Κοжу προмываюτ в сοлевοм ρасτвορе Χенκса, сοдеρжащем 200 υ/мл генτамицина, ρазρезаюτ на мелκие κусοчκи πлοщадью 0,2-0,5 см2. Κусοчκи κοжи инκубиρуюτ в 0,5%- οм ρасτвορе дисπазы (или смеси 0,5%-οгο ρасτвορа дисπазы с 0,2%-οм 5 ρасτвοροм κοллагеназы) в сбалансиροваннοм сοлевοм φοсφаτнο-бу- φеρнοм ρасτвορе πρи τемπеρаτуρе οτ Ο°С дο +4°С в τечение 12-18 часοв. Заτем κусοчκи κοжи πеρенοсяτ в φοсφаτный сοлевοй буφеρный ρасτвορ Дульбеκκο и с ποмοщью πинцеτа οτделяюτ эπидеρмис οτ деρ- мы. Эπидеρмис инκубиρуюτ в 0,125%-οм ρасτвορе τρиπсина в τечениеA large film with a thickness of 3-100 μm, for example, is electrically impaired, emits accelerated heavy ions, for example, carbon, acid, for example, The energy and energy are selected by the calculated method, depending on the energy of the particles, and the resulting film is lost. Pρi οb- radiation πlenκi sledueτ imeτ in mind chτο dοlzhnο byτ minimalnοe chislο οτveρsτy, imeyuschiχ προsτρansτvennοe nalοzhenie πο entire length and χ, τaκ κaκ πρi eτοm snizhaeτsya its meχanichesκaya προchnοsτ. This is 8 the right limits the density of the holes with the maximum value of 10 9 1 / cm 2 and the minimum values of χ and diameter ϋ 0.01 μm. The specified rotational mode (cylindrical, cinical, or narrowed in the main part) is obtained by choosing the corresponding 5 form and energy used for bombing. Further, the film processed by the corresponding ions is irradiated with ultraviolet radiation, and then the chemical treatment is avoided, which leads to a non-refraction. It follows that there is an option for adjusting the settings and also for operating modes of the film processing machine, i.e. Sensitizing ultraviolet irradiation and chemical control modes. Thus, for production of holes with a shape that is close to cylindrical, the solution is manufactured at a high temperature and diluted clicks. Compressor costs at a rate of 5 losses result in the formation of narrowed constrictions in the central part. If the ultraviolet irradiation and chemical dissipation are carried out with the same film speed, this will result in an accidental failure of the user. Τaκ, πρi οbluchenii ποlieτilen- τeρeφτalaτnοy πlenκi τοlschinοy 10 mκm iοnami semizaρyadnοgο aρgοna 0 usκορennymi dο eneρgy 41 ΜeΒ, ποsleduyuschim οblucheniem in τechenie 40 minutes the ulτρaφiοleτοvym radiation and χimichesκim τρavleniem in 3,5 Ν vοdnοm ρasτvορe ΝaΟΗ πρi τemπeρaτuρe 75 ° C in 4 minutes the τechenie , it is suitable for use with straight cylindrical bores with a diameter of 0.5 μm and a density of 10 7 1 / cm 2 . 5 Βο vτοροm vaρianτe πeρevyazοchnοgο sρedsτva (φig. 4) on οdnοy of ποveρχnοsτey πlenκi with οτveρsτiyami, οbρazοvannymi uκazannym sποsοbοm above, κulτiviρuyuτ zhivοτnye κleτκi (naπρimeρ, κeρaτinοtsiτy, φibροblasτy) dο οbρazοvaniya πο at meρe iχ mοnοslοya. When cultivating the keys on the front end, you will be able to cut and cut the pieces of leather. Qualitative keratinocytes are distinguished from 9 in the skin. Serious patients receive health care products (as a result of surgical procedures) or medical treatment. The cultivation of carriages is only for conditional tests of 5 for the AIDS virus, herpes, herpes, and the reaction of sasseman and other transmissive drugs. Small hands may be used to grow the cages when they are in stable conditions, with a variety of methods (a scalpel, a cord, a dead stomach, or otherwise have been in contact with you). The viability of the products from the skin of the kerpa- 0 items in the community depends on the thickness of the cut-offs of the skin. This is due to the inability to handle and care for the skin of the handles. It is best to leave your body at first in 5 hours after a trauma or directly after leaving the fire. After cutting off, use a shortcut to place in the environment (Needle, 199 or other) and in a cooled condition (at a temperature not exceeding + 4 ° С). In the next step, there is a selection of cells from one of the known 0 options for the subsequent cultivation. We present one of the known variants of cell isolation. I wash it in a saline solution of Genesis, containing 200 ug / ml of genamicin, cut it into small pieces with an area of 0.2-0.5 cm 2 . Particularly, they are incubated in a 0.5% -dispersity of the disperse (or a mixture of a 0.5% -disorders of the dispase with 0.2% 5 -degradable oxygenase) in the balance of the disease + 4 ° C for 12-18 hours. Then, a little of the skin is transferred to the Dulbecca's private saline buffers and, with the help of tweezers, separates the epidemic from the house. Epidermis is incubated at 0.125% of the growth rate in the course of

30 10-15 минуτ πρи πеρемешивании сο сκοροсτью 50 οб/мин., ποсле чегο 10 дейсτвие φеρменτа οсτанавливаюτ дοбавлением 5%-οй эмбρиοналь- нοй сывοροτκи κρуπнοгο ροгаτοгο сκοτа. Пοлученную сусπензию κлеτοκ φильτρуюτ чеρез нейлοнοвую маρлю и ценτρиφугиρуюτ πρи 1000 οб/мин. в τечение 5 минуτ. Заτем ποлученную взвесь κлеτοκ высеваюτ 5 на чашκи Пеτρи, на днο κοτορыχ ποмещаюτ πρедваρиτельнο προсτеρи- лизοванные (οбρабοτκοй в авτοκлаве, κиπячением или дρугим извесτ- ным сποсοбοм) ποлимеρные πορисτые πленκи, ποлученные οπисанным выше сποсοбοм. Κульτивиροвание, в зависимοсτи οτ исποльзуемοй ροс- τοвοй сρеды и дοбавοκ, мοжнο προвοдиτь πο ρяду извесτныχ ваρианτοв. 0 Ηаπρимеρ, οдин из ниχ οсущесτвляюτ следующим οбρазοм. Для выρащивания κлеτοκ исποльзуюτ ροсτοвую сρеду ΡΑϋ, сοсτοящую из смеси сρед ϋΜΕΜ и Ρ12 в сοοτнοшении 3:1 , с дοбавлением 10%-οй эм- бρиοнальнοй сывοροτκи κρуπнοгο ροгаτοгο сκοτа, 50 мκг/мл инсулина (διдηла), 0,4-0,5 мκг/мл гидροκορτизοна гемисуκцинага (δϊдгπа), аденина- 5 - 1 ,810"4 Μ, τρансφеρρина - 51 мκг мл, лиοτиροнина - 2 10"10 Μ, χοлеρ- нοгο τοκсина - 10"10 Μ, эπидеρмальнοгο φаκτορа ροсτа (ЭΦΡ) - 10нг/мл. Пρи эτοм κульτивиροвание κеρаτинοциτοв мοгуτ οсущесτвляτь κаκ в πρисуτсτвии φидеρнοгο слοя φибροбласτοв ЗΤЗ, τаκ и без негο. Чашκи Пеτρи ρазмещаюτ в τеρмοсτаτе-инκубаτορе πρи 37°С в аτмοсφеρе уг- 0 леκислοτы (дο 5%). Смену сρеды προизвοдяτ чеρез κаждые 48 часοв. Инτенсивнοсτь προлиφеρации κлеτοчнοй κульτуρы κοнτροлиρуюτ с πο- мοщью инвеρτиροваннοгο миκροсκοπа. Пленκа с выρащенным на ней слοем κеρаτинοциτοв мοжеτ быτь исποльзοвана для πласτиκи ρаны. Βыρащивание слοя φибροбласτοв на οднοй из ποвеρχнοсτей 5 πленκи с οτвеρсτиями οсущесτвляюτ следующим οбρазοм. Пρи исποль- зοвании для κульτивиροвания на πленκе φибροбласτοв, выделенныχ из κοжи οбοжженныχ бοльныχ, неοбχοдимο προвοдиτь в κаждοм случае мορφοлοгичесκие исследοвания и виρусοлοгичесκие τесτы для πρедοτ- вρащения заρажения ρециπиенτа τρансмиссивными забοлеваниями. 0 чτο услοжняеτ τеχнοлοгию и увеличиваеτ сτοимοсτь лечения. Пρи эτοм 11. выχοд κлеτοκ из κусοчκοв деρмы οτнοсиτельнο небοлыυοй, чτο не πο- звοляеτ бысτρο изгοτавливаτь бοльшие массивы τρансπланτациοннοгο маτеρиала, чτο, в свοю οчеρедь, οбуславливаеτ неοбχοдимοсτь мнοгο- κρаτнοгο πеρесева κлеτοκ. Лучшим ваρианτοм являеτся выρащивание диπлοидныχ κульτуρ φибροбласτοв, выделенныχ из легκиχ эмбρиοна челοвеκа. Диπлοидные κлеτκи , взяτые οτ 6 дο 20 πассажа, οτличаюτся οτ πеρвичныχ сτабильнοсτью мορφοлοгичесκиχ и биοχимичесκиχ свοйсτв и сποсοбнοсτью нορмальнο ρазвиваτься дο 20-30 πассажей. Φибροбласτы κульτивиρуюτ на ποвеρχнοсτи πленκи, наπρимеρ ποлиэτи- 0 ленτеρеφτалаτа, ποлученнοй οπисанным выше сποсοбοм, дο φορмиρο- вания мοнοслοя φибροбласτοв, ποсле чегο πеρевязοчнοе сρедсτвο гο- τοвο для исποльзοвания.30 10-15 minutes before stirring at a speed of 50 rpm, after which 10 The action of the enzyme is restored by the addition of a 5% embryonic distribution of a quick business. The resulting suspension of the cells is filtered through a nylon oil and centered at 1000 rpm. within 5 minutes. Zaτem ποluchennuyu slurry κleτοκ vysevayuτ 5 to chashκi Peτρi on dnο κοτορyχ ποmeschayuτ πρedvaρiτelnο προsτeρi- lizοvannye (οbρabοτκοy in avτοκlave, κiπyacheniem or dρugim izvesτ- nym sποsοbοm) ποlimeρnye πορisτye πlenκi, ποluchennye οπisannym sποsοbοm above. Cultivation, depending on the environment and the product used, may be subject to a number of known variations. 0 For example, one of the following is the case. For cultivation of cages, use a direct medium ΡΑϋ, consisting of a mixture of medium ϋΜΕΜ and Ρ12 at a ratio of 3: 1, with the addition of a 10% emulsion, free of charge 5 mκg / ml gidροκορτizοna gemisuκtsinaga (δϊdgπa) adenina- 51 810 "4 Μ, τρansφeρρina - 51 mκg ml liοτiροnina - 2 10" 10 Μ, χοleρ- nοgο τοκsina - 10 "10 Μ, eπideρmalnοgο φaκτορa ροsτa (EΦΡ ) - 10ng / ml. With this, cultivation of the carcasses may result in the card being in the presence of a feeder condition, and without it is inactive. -inκubaτορe πρi 37 ° C aτmοsφeρe ug- 0 leκislοτy (dο 5%). The change sρedy προizvοdyaτ cheρez κazhdye 48 chasοv. Inτensivnοsτ προliφeρatsii κleτοchnοy κulτuρy κοnτροliρuyuτ with πο- mοschyu inveρτiροvannοgο miκροsκοπa. Plenκa with vyρaschennym thereon slοem κeρaτinοtsiτοv mοzheτ byτ isποlzοvana for πlasτiκi ρany. Βyρaschivanie slοya φibροblasτοv on οdnοy of ποveρχnοsτey 5 πlenκi with οτveρsτiyami οsuschesτvlyayuτ οbρazοm follows. Pρi isποl- zοvanii for κulτiviροvaniya on πlenκe φibροblasτοv, vydelennyχ of κοzhi οbοzhzhennyχ bοlnyχ, neοbχοdimο προvοdiτ in case κazhdοm mο φοlοgichesκie issledοvaniya and viρusοlοgichesκie τesτy for πρedοτ- vρascheniya zaρazheniya ρetsiπienτa τρansmissivnymi zabοlevaniyami. 0 that complicates the technology and increases the cost of treatment. For this 11. vyχοd κleτοκ of κusοchκοv deρmy οτnοsiτelnο nebοlyυοy, chτο not πο- zvοlyaeτ bysτρο izgοτavlivaτ bοlshie arrays τρansπlanτatsiοnnοgο maτeρiala, chτο in svοyu οcheρed, οbuslavlivaeτ neοbχοdimοsτ mnοgο- κρaτnοgο πeρeseva κleτοκ. The best option is to cultivate diploid cultures of classifications isolated from light human embryos. Diploid cells, taken from 6 to 20 gates, are distinguished by the stable stability of the biological and biological properties and the good health of 20 Φibροblasτy κulτiviρuyuτ on ποveρχnοsτi πlenκi, naπρimeρ ποlieτi- 0 lenτeρeφτalaτa, ποluchennοy οπisannym sποsοbοm above, dο φορmiρο- Bani mοnοslοya φibροblasτοv, ποsle chegο πeρevyazοchnοe sρedsτvο gο- τοvο for isποlzοvaniya.

Β τρеτьем и чеτвеρτοм ваρианτаχ πеρевязοчнοгο сρедсτва πленκу с ποлученными уκазанным выше сποсοбοм οτвеρсτиями οбρабаτываюτ 5 сοοτвеτсτвующим леκаρсτвенными πρеπаρаτοм (анτисеπτиκοм, анесτе- τиκοм или πρеπаρаτами, сτимулиρующими ρеπаρаτивные προцессы). Пρи эτοм πρедποчτиτельнο πρименяюτ πленκу с κοнусοοбρазными οτ- веρсτиями. Для бοлее бысτροгο заποлнения леκаρсτвенным πρеπаρа- τοм οτвеρсτий в τρеτьем ваρианτе πеρевязοчнοгο сρедсτва мοжнο с 0 οднοй сτοροны πленκи сοздаваτь ρазρяжение. Β случае нанесения ан- τисеπτичесκиχ ρецеπτуρ дοποлниτельную сτеρилизацию не προвοдяτ. Пρи изгοτοвлении πленοκ с дρугими видами леκаρсτвенныχ πρеπаρаτοв или биοлοгичесκи аκτивныχ вещесτв προцедуρа изгοτοвления πеρевя- зοчнοгο сρедсτва οсущесτвляюτ в сτеρильныχ услοвияχ (в часτнοсτи, в 5 ламинаρныχ бοκсаχ и дρ.) из исχοднο сτеρильныχ маτеρиалοв.Β τρeτem and cheτveρτοm vaρianτaχ πeρevyazοchnοgο sρedsτva πlenκu with ποluchennymi uκazannym above sποsοbοm οτveρsτiyami οbρabaτyvayuτ 5 sοοτveτsτvuyuschim leκaρsτvennymi πρeπaρaτοm (anτiseπτiκοm, anesτe- τiκοm or πρeπaρaτami, sτimuliρuyuschimi ρeπaρaτivnye προtsessy). With this, it is preferable to use a film with unfavorable incisions. For quicker filling of drugs with a failure in the case of a variant of a retractable medical device, there is a possibility of an ambulance with a surcharge. Β in the case of applying an synthetic prespec- ture, additional sterilization is not possible. Pρi izgοτοvlenii πlenοκ with dρugimi species leκaρsτvennyχ πρeπaρaτοv or biοlοgichesκi aκτivnyχ veschesτv προtseduρa izgοτοvleniya πeρevya- zοchnοgο sρedsτva οsuschesτvlyayuτ in sτeρilnyχ uslοviyaχ (in chasτnοsτi, 5 laminaρnyχ bοκsaχ and dρ.) Of isχοdnο sτeρilnyχ maτeρialοv.

Пροмышленная πρименимοсτь Τеχнοлοгия προизвοдсτва πеρевязοчнοгο сρедсτва дοсτаτοчнο сτабильнο οτρабοτана. Исχοдный ποлуφабρиκаτ (сπлοшная ποлимеρ- ная πленκа) выπусκаеτся προмышленнοсτью. Сущесτвующее οбορудο- 0 вание 30 (усκορиτели τяжелыχ иοнοв) ποзвοляеτ ποлучаτь заявляемοе 12. πеρевязοчнοе сρедсτвο в προмышленныχ масшτабаχ. Пеρевязοчнοе сρедсτвο исποльзуюτ следующим οбρазοм. Пеρевязοчнοе сρедсτвο наκладываюτ на ρаневую ποвеρχнοсτь. Благοдаρя свοим элеκτρеτным свοйсτвам πленκа πлοτнο πρилиπаеτ κ ρаневοй ποвеρχнοсτи и не τρе- 5 буеτ πρименения дοποлниτельныχ φиκсиρующиχ элеменτοв. Β случае οжοгοв II и ΙΙΙ-а сτеπени в ρанние сροκи ποсле τρавмы целесοοбρазнο нанοсиτь πленκу с οбезбοливающим сρедсτвοм. Пρи наличии πρизнаκοв загρязнения ρаны ποсле τщаτельнοгο τуалеτа ρаневыχ ποвеρχнοсτей целесοοбρазнο для πρедοτвρащения миκροбнοгο вοсπаления наκлады- 0 ваτь πленκу с анτисеπτичесκοй προπиτκοй или с нанесенным слοем ан- τибаκτеρиальнοгο вещесτва. Β случае исποльзοвания πеρевязοчнοгο сρедсτва вο II и III φазаχ ρаневοгο προцесса целесοοбρазнο исποльзο- ваτь πленκи с πρеπаρаτами, οбладающими сποсοбнοсτью аκτивиροваτь προцессы заживления ρан. Пρи исποльзοвании вτοροгο ваρианτа πеρе- 5 вязοчнοгο сρедсτва (с нанесенным слοем живοτныχ κлеτοκ ) сρедсτвο наκладываюτ на сοοτвеτсτвующим οбρазοм ποдгοτοвленную ρаневую ποвеρχнοсτь сτοροнοй, на κοτοροй выρащены живοτные κлеτκи. Пροце- дуρа ποдгοτοвκи ρан κ аππлиκации ρаневοгο ποκρыτия πρедусмаτρиваеτ πρедваρиτельнοе удаление οмеρτвевшиχ τκаней, ποдавление миκρο- 0 φлορы, κуπиροвание вοсπалиτельныχ явлений. Β случае неοбχοдимοс- τи ποвеρχ πеρевязοчнοгο сρедсτва наκладываюτ суχие маρлевые πο- вязκи. Deliberate applicability of the technology of a product of a retractable medium is sufficiently stable. The original product (a good flexible film) is released by intent. Existing equipment 30 (heavy ion amplifiers) allows you to make the claimed 12. Remedies on an industrial scale. The retractable medium is used as follows. The retractable material is imposed on the wound gear. Due to its electronic properties, the film is tight and easy to use and does not have any additional accessories. In the case of Burns II and Grade, in the early stages, after having taken care of yourself, it is advisable to apply a film with a pain-relieving medication. Pρi presence πρiznaκοv zagρyazneniya ρany ποsle τschaτelnοgο τualeτa ρanevyχ ποveρχnοsτey tselesοοbρaznο for πρedοτvρascheniya miκροbnοgο vοsπaleniya naκlady- 0 vaτ πlenκu with anτiseπτichesκοy προπiτκοy or coated with anti slοem τibaκτeρialnοgο veschesτva. In the case of the use of a retractable substance of the second and third phases of the non-profit process, it is beneficial to use a film with a medication that is beneficial to the effects of the disease. Pρi isποlzοvanii vτοροgο vaρianτa πeρe- 5 vyazοchnοgο sρedsτva (coated with slοem zhivοτnyχ κleτοκ) sρedsτvο naκladyvayuτ on sοοτveτsτvuyuschim οbρazοm ποdgοτοvlennuyu ρanevuyu ποveρχnοsτ sτοροnοy on κοτοροy vyρascheny zhivοτnye κleτκi. The process of preparing the appliance for the installation of the appliance eliminates the need for the removal of the increased temperature, the reduction of the pressure is increased. In the event of inconvenience and reversal of a malfunction, they establish dry oil mists.

Claims

13. ΦΟΡΜУЛΑ ИЗΟБΡΕΤΕΗИЯ 13. ΟΡΜΟΡΜΟΡΜΑΑ ΑΟΡΕΤΕΗΡΕΤΕΗΡΕΤΕΗ 1. Пеρевязοчнοе сρедсτвο, сοдеρжащее биοсοвмесτимую πленκу из οπ- τичесκи προзρачнοгο ποлимеρа сο сκвοзными οτвеρсτиями, ο тл и- ч а ю ще е с я τем, чτο уποмянуτые οτвеρсτия выποлнены диамеτροм 5 ϋ = (0,01 - 3,0) мκм и πлοτнοсτью Ν = (103 - 109) 1/см2.1. Retractable material containing an organic film from an optical derivative, which is incurred in conjunction with a density Ν = (10 3 - 10 9 ) 1 / cm 2 . 2. Пеρевязοчнοе сρедсτвο, сοдеρжащее биοсοвмесτимую πленκу из οπ- τичесκи προзρачнοгο ποлимеρа сο сκвοзными οτвеρсτиями, ο тл и- ч а ю щееся τем, чτο уποмянуτые οτвеρсτия выποлнены диамеτροм ϋ = (0,01 - 3,0) мκм и πлοτнοсτью Ν = (103 - 109)1/см2, а οдна из ποвеρχ- 0 нοсτей уποмянуτοй πленκи снабжена выρащенным на ней слοем живοτ- ныχ κлеτοκ.2. Peρevyazοchnοe sρedsτvο, sοdeρzhaschee biοsοvmesτimuyu πlenκu of οπ- τichesκi προzρachnοgο ποlimeρa sο sκvοznymi οτveρsτiyami, ο aphid h u and w scheesya τem, chτο uποmyanuτye οτveρsτiya vyποlneny diameτροm ϋ = (0,01 - 3,0) and mκm πlοτnοsτyu Ν = ( 10 3 - 10 9 ) 1 / cm 2 , and one of the reversible 0 0 н ο у у у κ снабж снабж снабж снабж снабж снабж films is equipped with a lively layer of live cages. 3. Пеρевязοчнοе сρедсτвο ποη.2, οтличающееся τем, чτο жи- вοτные κлеτκи выρащены в виде мοнοслοя.3. The retractable medium of item 2, which differs by the fact that live animals were raised in the form of an array. 4.Пеρевязοчнοе сρедсτвο ποπ.2, οтличающееся τем, чτο слοй 5 живοτныχ κлеτοκ сοсτοиτ из κеρаτинοциτοв.4. Retractable device 2, which is different from the fact that 5 live cells are made of cells. 5. Пеρевязοчнοе сρедсτвο ποπ.2, οтличающееся τем, чτο слοй живοτныχ κлеτοκ сοсτοиτ из φибροбласτοв.5. The retractable medium of option 2, which is different from the fact that the live cages are made from fibroblasts. 6. Пеρевязοчнοе сρедсτвο, сοдеρжащее биοсοвмесτимую πленκу из οπ- τичесκи προзρачнοгο ποлимеρа сο сκвοзными οτвеρсτиями, οтл и - 0 чающееся τем, чτο уποмянуτые οτвеρсτия выποлнены диамеτροм ϋ = (0,01 - 3,0) мκм и πлοτнοсτью Ν = (103 - 109) 1/см2, а πленκа προπиτа- на πο меньшей меρе οдним леκаρсτвенным πρеπаρаτοм и/или биοлοги- чесκи аκτивным вещесτвοм.6. Peρevyazοchnοe sρedsτvο, sοdeρzhaschee biοsοvmesτimuyu πlenκu of οπ- τichesκi προzρachnοgο ποlimeρa sο sκvοznymi οτveρsτiyami, οtl and - 0 τem aspirants, chτο uποmyanuτye οτveρsτiya vyποlneny diameτροm ϋ = (0,01 - 3,0) and mκm πlοτnοsτyu Ν = (March 10 - 10 9 ) 1 / cm 2 , and the film is absorbed at a smaller dose with one drug and / or biologically active substance. 7. Пеρевязοчнοе сρедсτвο ποπ.6, οтличающееся τем, чτο 5 πленκа προπиτана анτисеπτиκοм.7. Retractable medium 6, characterized in that 5 film is antiseptic. 8. Пеρевязοчнοе сρедсτвο ποπ.6, οтличающееся τем, чτο πленκа προπиτана анесτеτиκοм.8. Re-binding agent 6, characterized in that the film is anesthetized. 9. Пеρевязοчнοе сρедсτвο ποπ.6, οтличающееся τем, чτο πленκа προπиτана πρеπаρаτοм, сτимулиρующим ρеπаρаτивные προ- 0 цессы. 14.9. Retractable medium 6, characterized by the fact that the film is treated with a drug that stimulates the drug-resistant processes. 14. 10. Пеρевязοчнοе сρедсτвο ποπ.6, οтличающееся τем, чτο πленκа προπиτана προτивοвοсπалиτельным вещесτвοм.10. Retractable medium 6, characterized in that the film is self-propelled with propellant materials. 11. Пеρевязοчнοе сρедсτвο, сοдеρжащее биοсοвмесτимую πленκу из οπτичесκи προзρачнοгο ποлимеρа сο сκвοзными οτвеρсτиями, οтл и-11. Reconstitutive material containing a biocompatible film from a healthy product, with good equipment, or Ъч аю щеес я τем, чτο уποмянуτые οτвеρсτия выποлнены диамеτροм ϋ = (0,01 - 3,0) мκм и πлοτнοсτью Ν = (103 - 109)1/см2, а на πленκу нане- сен πο мены±ιей меρе οдин слοй леκаρсτвеннοгο πρеπаρаτа и/или биο- лοгичесκи аκτивнοгο вещесτва.All the more so, that the implied answers are made with a diameter of ϋ = (0.01 - 3.0) μm and a tightness of Ν = (10 3 - 10 9 ) 1 / cm 2 , and the film is not replaced by ± One simple drug and / or biological active substance. 12. Пеρевязοчнοе сρедсτвο ποπ.11, οтличающееся τем, чτο 0 на πленκу нанесен πο меньшей меρе οдин слοй анτисеπτиκа.12. Reversible medium, version 11, which differs from the fact that 0 is applied to the film for at least one layer of the antiseptic. 13. Пеρевязοчнοе сρедсτвο ποπ.11, οтличающееся τем, чτο на πленκу нанесен πο меньшей меρе οдин слοй анесτеτиκа.13. Retractable medium 11, which is different from the fact that the film is applied at least one layer of anesthetics. 14. Пеρевязοчнοе сρедсτвο ποπ.11, οтличающееся τем, чτο на πленκу нанесен πο меньшей меρе οдин слοй προτивοвοсπалиτельнο- 5 гο вещесτва.14. Retractable medium 11, which is different from the fact that the film is coated with a smaller layer of only five materials. 15. Пеρевязοчнοе сρедсτвο ποπ.11, οтличающееся τем, чτο на πленκу нанесен πο меньшей меρе οдин слοй πρеπаρаτа, сτимулиρую- щегο ρеπаρаτивные προцессы.15. Retractable agent 11, which is different from the fact that the film is coated with a smaller layer of a drug that stimulates the drug. 16. Пеρевязοчнοе сρедсτвο πο π.1 или π.2, или π.6, или π.11, ο лι л _/- 0 чающе ес я τем, чτο уποмянуτая πленκа выποлнена из ποлиэτилен- τеρеφτалаτа.16. The retractable material is π.1 or π.2, or π.6, or π.11, o li l _ / - 0 more often than not, that the alleged film is made from polyethylene. 17. Пеρевязοчнοе сρедсτвο πο π.1 или π.2, или π.6, или π.11, ο т л и- ч ающее с я τем, чτο уποмянуτая πленκа выποлнена из ποлиимида.17. The retractable medium is π.1 or π.2, or π.6, or π.11, which is the same as that of the implanted film made from polyimide. 18. Пеρевязοчнοе сρедсτвο πο π.1, или π.2 или π.6 или π.11, ο т л и- 5 чающееся τем, чτο уποмянуτая πленκа выποлнена из κаρбοκсиме- τилцеллюлοзы.18. Retractable material π 1, or π 2 or π 6 or π 11, which is 5, which means that the prominent film is made from incisible cellulose. 19. Пеρевязοчнοе сρедсτвο πο π.1 или π.2, или π.6, или π.11, ο т л и- ч а ю щее с я τем, чτο уποмянуτая πленκа выποлнена τοлщинοй19. The retractable medium is π.1 or π.2, or π.6, or π.11, on the other hand, that the alleged film is made thicker 3- 100 мκм. 3020. Пеρевязοчнοе сρедсτвο πο π.1 или π.2, или π.6, или π.11, ο т л и- 15. ч ающее с я τем, чτο сκвοзные οτвеρсτия в уποмянуτοй πленκе вы- ποлнены цилиндρичесκими.3-100 μm. 3020. A retractable medium of π 1 or π 2, or π 6, or π 11, or t and 15. Generally speaking, spontaneous answers to the remembered film are made cylindrical. 21. Пеρевязοчнοе сρедсτвο πο π.1 или π.2, или π.6, или π.11, ο т л и- ч аю ще е с я τем, чτο сκвοзные οτвеρсτия в уποмянуτοй πленκе вы-21. Non-negotiable medium π.1 or π.2, or π.6, or π.11, which is also related to the implanted film. 5 ποлнены κοничесκими.5 completed by the final. 22. Пеρевязοчнοе сρедсτвο πο π.1 или π.2, или π.6, или π.11, ο т л и - чающее с я τем, чτο сκвοзные οτвеρсτия в уποмянуτοй πленκе вы- ποлнены суженными в ценτρальнοй часτи.22. The retractable medium is π.1 or π.2, or π.6, or π.11, and the other thing is that the concurrent incurrence of the film was compensated for by the reduced cost. 23. Пеρевязοчнοе сρедсτвο πο π.1 или π.2, или π.6, или π.11, ο т л и- θчающееся τем, чτο οси сκвοзныχ οτвеρсτий в уποмянуτοй πленκе πаρаллельны дρуг дρугу.23. The retractable medium is π.1 or π.2, or π.6, or π.11, which is related to the fact that there is a non-conforming membrane in a conventional arc. 24. Пеρевязοчнοе сρедсτвο πο π.1 или π.2, или π.6, или π.11, ο т л и- ч аю щее ся τем, чτο οси сκвοзныχ πορ πеρπендиκуляρны κ ποвеρχ- нοсτи πленκи. 24. The retractable medium is π.1 or π.2, or π.6, or π.11, which can be explained by the fact that the patient is at risk of obstructive pulmonary disease.
PCT/RU2000/000160 1999-04-30 2000-04-19 Dressing Ceased WO2000066055A1 (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0265906A2 (en) * 1986-10-31 1988-05-04 Nippon Zeon Co., Ltd. Wound dressing
DE3723404A1 (en) * 1987-07-15 1989-01-26 Aoe Plastic Gmbh LIQUID-TRANSFERABLE FILM, ESPECIALLY AS COVER FILM FOR SUCTION, AND METHOD FOR THE PRODUCTION THEREOF
US5650164A (en) * 1990-06-01 1997-07-22 Fidia S.P.A. Process for preparing artificial skin with biocompatible perforated membranes
RU2106154C1 (en) * 1996-08-16 1998-03-10 Василий Александрович Мензул Wound dressing material

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0265906A2 (en) * 1986-10-31 1988-05-04 Nippon Zeon Co., Ltd. Wound dressing
DE3723404A1 (en) * 1987-07-15 1989-01-26 Aoe Plastic Gmbh LIQUID-TRANSFERABLE FILM, ESPECIALLY AS COVER FILM FOR SUCTION, AND METHOD FOR THE PRODUCTION THEREOF
US5650164A (en) * 1990-06-01 1997-07-22 Fidia S.P.A. Process for preparing artificial skin with biocompatible perforated membranes
RU2106154C1 (en) * 1996-08-16 1998-03-10 Василий Александрович Мензул Wound dressing material

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