[go: up one dir, main page]

WO2000062813A3 - Lipides peg cationiques et méthodes d'utilisation - Google Patents

Lipides peg cationiques et méthodes d'utilisation Download PDF

Info

Publication number
WO2000062813A3
WO2000062813A3 PCT/CA2000/000451 CA0000451W WO0062813A3 WO 2000062813 A3 WO2000062813 A3 WO 2000062813A3 CA 0000451 W CA0000451 W CA 0000451W WO 0062813 A3 WO0062813 A3 WO 0062813A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipid
cationic
lipids
methods
cpls
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2000/000451
Other languages
English (en)
Other versions
WO2000062813A2 (fr
Inventor
Pieter R Cullis
Tao Chen
David B Fenske
Lorne R Palmer
Kim Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of British Columbia filed Critical University of British Columbia
Priority to AU40962/00A priority Critical patent/AU783647B2/en
Priority to CA002370690A priority patent/CA2370690A1/fr
Priority to JP2000611949A priority patent/JP5117648B2/ja
Priority to EP00920309A priority patent/EP1173600A2/fr
Publication of WO2000062813A2 publication Critical patent/WO2000062813A2/fr
Priority to AU5454801A priority patent/AU5454801A/xx
Priority to CA002406654A priority patent/CA2406654A1/fr
Priority to JP2001577996A priority patent/JP2004508012A/ja
Priority to PCT/CA2001/000555 priority patent/WO2001080900A2/fr
Priority to AU2001254548A priority patent/AU2001254548B2/en
Priority to US09/839,707 priority patent/US7189705B2/en
Priority to EP01927519A priority patent/EP1355670A2/fr
Publication of WO2000062813A3 publication Critical patent/WO2000062813A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Cette invention a trait à des conjugats polymère-lipide-cationique (CPL) tel que des conjugats poly(éthylène glycol)-lipide-cationique distaux pouvant être incorporés à des liposomes classiques ou à des liposomes furtifs ou à toute autre formulation à base de lipide pour renforcer l'absorption cellulaire. Les CPL selon l'invention comportent une fraction lipidique, un polymère hydrophile et une fraction polycationique. L'invention concerne également une méthode permettant de renforcer la libération intracellulaire d'acides nucléiques.
PCT/CA2000/000451 1999-04-20 2000-04-20 Lipides peg cationiques et méthodes d'utilisation Ceased WO2000062813A2 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
AU40962/00A AU783647B2 (en) 1999-04-20 2000-04-20 Cationic peg-lipids and methods of use
CA002370690A CA2370690A1 (fr) 1999-04-20 2000-04-20 Lipides peg cationiques et methodes d'utilisation
JP2000611949A JP5117648B2 (ja) 1999-04-20 2000-04-20 カチオン性ｐｅｇ脂質および使用方法。
EP00920309A EP1173600A2 (fr) 1999-04-20 2000-04-20 Lipides peg cationiques et m thodes d'utilisation
EP01927519A EP1355670A2 (fr) 2000-04-20 2001-04-20 Procedes permettant d'ameliorer la transfection a mediation splp (particule plasmide-lipide stabilisee) au moyen de destabilisateurs de la membrane endosomale
AU5454801A AU5454801A (en) 2000-04-20 2001-04-20 Methods of enhancing splp-mediated transfection using endosomal membrane destabilizers
CA002406654A CA2406654A1 (fr) 2000-04-20 2001-04-20 Procedes permettant d'ameliorer la transfection a mediation splp (particule plasmide-lipide stabilisee) au moyen de destabilisateurs de la membrane endosomale
JP2001577996A JP2004508012A (ja) 2000-04-20 2001-04-20 エンドソーム膜不安定剤を用いたｓｐｌｐ媒介性トランスフェクションの強化方法
PCT/CA2001/000555 WO2001080900A2 (fr) 2000-04-20 2001-04-20 Procedes permettant d'ameliorer la transfection a mediation splp (particule plasmide-lipide stabilisee) au moyen de destabilisateurs de la membrane endosomale
AU2001254548A AU2001254548B2 (en) 2000-04-20 2001-04-20 Enhanced stabilised plasmid-lipid particle-mediated transfection using endosomal membrane
US09/839,707 US7189705B2 (en) 2000-04-20 2001-04-20 Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13015199P 1999-04-20 1999-04-20
US60/130,151 1999-04-20

Publications (2)

Publication Number Publication Date
WO2000062813A2 WO2000062813A2 (fr) 2000-10-26
WO2000062813A3 true WO2000062813A3 (fr) 2001-08-09

Family

ID=22443303

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/000451 Ceased WO2000062813A2 (fr) 1999-04-20 2000-04-20 Lipides peg cationiques et méthodes d'utilisation

Country Status (5)

Country Link
EP (1) EP1173600A2 (fr)
JP (2) JP5117648B2 (fr)
AU (1) AU783647B2 (fr)
CA (1) CA2370690A1 (fr)
WO (1) WO2000062813A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
US9655822B2 (en) 2004-05-25 2017-05-23 Basf Beauty Care Solutions France S.A.S. Hydrated lamellar phases or liposomes which contain a fatty monoamine or a cationic polymer which promotes intracellular penetration, and a cosmetic or pharmaceutical composition containing same, as well as a method of screening such a substance

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4656675B2 (ja) 1997-05-14 2011-03-23 ユニバーシティー オブ ブリティッシュ コロンビア 脂質小胞への荷電した治療剤の高率封入
US7189705B2 (en) 2000-04-20 2007-03-13 The University Of British Columbia Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
WO2001080900A2 (fr) * 2000-04-20 2001-11-01 The University Of British Columbia Procedes permettant d'ameliorer la transfection a mediation splp (particule plasmide-lipide stabilisee) au moyen de destabilisateurs de la membrane endosomale
ATE354350T1 (de) * 2000-10-25 2007-03-15 Univ British Columbia Lipidformulierungen zur zielgerichteten abgabe
US6610322B1 (en) * 2000-12-20 2003-08-26 Brian Charles Keller Self forming, thermodynamically stable liposomes and their applications
JP4722481B2 (ja) 2002-06-28 2011-07-13 プロティバ バイオセラピューティクス リミテッド リポソーム製造方法および装置
WO2004082626A2 (fr) * 2003-03-18 2004-09-30 Ethicon, Inc. Diagnostic et traitement faisant appel a un inhibiteur de l'aromatase
US20050064595A1 (en) 2003-07-16 2005-03-24 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering RNA
NZ581166A (en) * 2003-09-15 2011-06-30 Protiva Biotherapeutics Inc Polyethyleneglycol-modified lipid compounds and uses thereof
US7799565B2 (en) 2004-06-07 2010-09-21 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering RNA
JP2009507049A (ja) * 2005-09-09 2009-02-19 北京徳科瑞医薬科技有限公司 リン脂質のポリエチレングリコール誘導体に包み込まれたビンカアルカロイド系制癌剤のナノミセル製剤
WO2007051303A1 (fr) 2005-11-02 2007-05-10 Protiva Biotherapeutics, Inc. Molecules d'arnsi modifiees et utilisations de celles-ci
US8877206B2 (en) 2007-03-22 2014-11-04 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
AU2008342535B2 (en) 2007-12-27 2015-02-05 Arbutus Biopharma Corporation Silencing of polo-like kinase expression using interfering RNA
NZ588583A (en) 2008-04-15 2012-08-31 Protiva Biotherapeutics Inc Novel lipid formulations for nucleic acid delivery
CA2721380A1 (fr) 2008-04-15 2009-10-22 Protiva Biotherapeutics, Inc. Reduction au silence de l'expression du gene csn5 au moyen d'arn interferant
US9789129B2 (en) 2008-04-17 2017-10-17 Pds Biotechnology Corporation Stimulation of an immune response by enantiomers of cationic lipids
CA2743136C (fr) 2008-11-10 2019-02-26 Muthiah Manoharan Nouveaux lipides et nouvelles compositions pour l'administration d'agents therapeutiques
ES2613498T3 (es) 2009-07-01 2017-05-24 Protiva Biotherapeutics Inc. Nuevas formulaciones de lípidos para el suministro de agentes terapéuticos a tumores sólidos
US8569256B2 (en) 2009-07-01 2013-10-29 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
US8716464B2 (en) 2009-07-20 2014-05-06 Thomas W. Geisbert Compositions and methods for silencing Ebola virus gene expression
US9222086B2 (en) 2009-09-23 2015-12-29 Protiva Biotherapeutics, Inc. Compositions and methods for silencing genes expressed in cancer
ME03327B (fr) 2009-12-01 2019-10-20 Translate Bio Inc Dérivé de stéroïdée suitable pour l'administration d'arnm dans des maladies génétiques humaines
WO2011141704A1 (fr) 2010-05-12 2011-11-17 Protiva Biotherapeutics, Inc Nouveaux lipides cationiques cycliques et procédés d'utilisation
EP2569276B1 (fr) 2010-05-12 2021-02-24 Arbutus Biopharma Corporation Nouveaux lipides cationiques et procédés d'utilisation de ceux-ci
AU2011268146A1 (en) 2010-06-17 2013-01-10 Actogenix Nv Compositions and methods for treating inflammatory conditions
WO2012000104A1 (fr) 2010-06-30 2012-01-05 Protiva Biotherapeutics, Inc. Systèmes non liposomaux pour une administration d'acide nucléique
CN103906527B (zh) 2011-06-08 2020-07-10 川斯勒佰尔公司 Mrna递送的脂质纳米颗粒组合物和方法
US11073451B2 (en) 2011-12-19 2021-07-27 Kode Biotech Limited Biocompatible method of functionalising substrates with inert surfaces
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
NZ700075A (en) 2012-02-24 2016-05-27 Protiva Biotherapeutics Inc Trialkyl cationic lipids and methods of use thereof
CA2867169C (fr) * 2012-03-16 2021-07-06 Merck Patent Gmbh Lipides de ciblage de type acide amine
WO2013185067A1 (fr) 2012-06-08 2013-12-12 Shire Human Genetic Therapies, Inc. Polynucléotides résistant à la nucléase et leurs utilisations
EP2861245B1 (fr) 2012-06-15 2019-10-16 PDS Biotechnology Corporation Compositions de vaccins comportant des lipides cationiques et leurs procédés d'utilisation
CN105101991A (zh) 2012-09-21 2015-11-25 Pds生物科技公司 改进的疫苗组合物和使用方法
HUE042640T2 (hu) 2013-03-14 2019-07-29 Translate Bio Inc CFTR-mRNS-készítmények, valamint kapcsolódó eljárások és alkalmazások
CN105051190A (zh) 2013-03-14 2015-11-11 夏尔人类遗传性治疗公司 信使rna的纯化方法
CN105555757A (zh) 2013-07-23 2016-05-04 普洛体维生物治疗公司 用于递送信使rna的组合物和方法
EA201992208A1 (ru) 2013-10-22 2020-07-31 Транслейт Био, Инк. ЛЕЧЕНИЕ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК
CA2928188A1 (fr) 2013-10-22 2015-04-30 Shire Human Genetic Therapies, Inc. Therapie arnm pour deficience en argininosuccinate synthetase
JP6571679B2 (ja) 2014-04-25 2019-09-04 トランスレイト バイオ， インコーポレイテッド メッセンジャーｒｎａの精製方法
AU2015328012A1 (en) 2014-10-02 2017-05-11 Arbutus Biopharma Corporation Compositions and methods for silencing Hepatitis B virus gene expression
US20180245074A1 (en) 2015-06-04 2018-08-30 Protiva Biotherapeutics, Inc. Treating hepatitis b virus infection using crispr
CN108350455A (zh) 2015-07-29 2018-07-31 阿布特斯生物制药公司 用于使b型肝炎病毒基因表达沉默的组合物和方法
EP3340967B1 (fr) 2015-08-24 2024-05-22 Halo-Bio Rnai Therapeutics, Inc. Nanoparticules polynucléotidiques pour la modulation de l'expression génique et leurs utilisations
US11612652B2 (en) 2015-11-13 2023-03-28 Pds Biotechnology Corporation Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy
AU2017286980B2 (en) 2016-06-30 2023-10-26 Arbutus Biopharma Corporation Compositions and methods for delivering messenger RNA
EP4653462A2 (fr) 2016-08-22 2025-11-26 Arbutus Biopharma Corporation Anticorps anti-pd-1, ou fragments de ceux-ci, pour le traitement de l'hépatite b
MX2019010155A (es) 2017-02-27 2020-12-10 Translate Bio Inc Arnm de cftr optimizado por codón novedoso.
US11173190B2 (en) 2017-05-16 2021-11-16 Translate Bio, Inc. Treatment of cystic fibrosis by delivery of codon-optimized mRNA encoding CFTR
EP3841208A1 (fr) 2018-08-24 2021-06-30 Translate Bio, Inc. Procédés de purification d'arn messager
WO2020106946A1 (fr) 2018-11-21 2020-05-28 Translate Bio, Inc. Traitement de la fibrose kystique par administration d'arnm nébulisé codant pour la cftr
GB201910299D0 (en) 2019-07-18 2019-09-04 Aouadi Myriam Medical uses, methods and uses
KR102650691B1 (ko) * 2019-12-20 2024-03-25 주식회사 삼양홀딩스 폴리락트산염을 포함하는 약물전달용 나노입자 조성물 제조용 키트
JP7709981B2 (ja) 2020-03-17 2025-07-17 ジェネヴァント サイエンシズ ゲーエムベーハー 肝星細胞への治療薬の脂質ナノ粒子送達のためのカチオン性脂質
MX2023006056A (es) 2020-11-25 2023-06-06 Akagera Medicines Inc Nanoparticulas lipidicas para suministro de acidos nucleicos y metodos de uso de las mismas.
CA3250180A1 (fr) 2022-01-31 2023-08-03 Genevant Sciences Gmbh Lipides cationiques ionisables pour nanoparticules lipidiques
EP4531819A2 (fr) 2022-05-25 2025-04-09 Akagera Medicines, Inc. Nanoparticules lipidiques pour l'administration d'acides nucléiques et leurs procédés d'utilisation
WO2024214632A1 (fr) * 2023-04-14 2024-10-17 国立大学法人 東京大学 Polymère cationique contenant un groupe phosphonium, et particules polymères et composition pharmaceutique le contenant
WO2025052278A1 (fr) 2023-09-05 2025-03-13 Genevant Sciences Gmbh Lipides cationiques à base de pyrrolidine pour administration de nanoparticules lipidiques d'agents thérapeutiques à des cellules stellaires hépatiques
WO2025158420A1 (fr) 2024-01-25 2025-07-31 Nanocell Therapeutics Holdings B.V. Méthodes et composition pour induire l'activation et l'expression d'adn dans des lymphocytes t
WO2025169168A1 (fr) 2024-02-09 2025-08-14 Nanocell Therapeutics Holdings B.V. Transfection extracorporelle de cellules effectrices immunitaires

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016202A2 (fr) * 1996-10-11 1998-04-23 Sequus Pharmaceuticals, Inc. Composition a base de liposomes fusogenes et procede correspondant
WO1998046208A1 (fr) * 1997-04-17 1998-10-22 The Regents Of The University Of Michigan Systeme de delivrance d'adn de follicule pileux
WO1998051285A2 (fr) * 1997-05-15 1998-11-19 Genzyme Corporation Formulations amphiphiles cationiques
WO1999005303A1 (fr) * 1997-07-24 1999-02-04 Inex Pharmaceuticals Corporation Preparation de particules de lipides-acides nucleiques grace a un procede d'extraction par solvant et d'hydratation directe
WO1999005094A1 (fr) * 1997-07-23 1999-02-04 Ribozyme Pharmaceuticals, Incorporated Nouvelles compositions d'administration de molecules chargees negativement
WO1999065461A2 (fr) * 1998-06-19 1999-12-23 Genzyme Corporation Complexes micellaires d'amphiphiles cationiques
WO2000043043A1 (fr) * 1999-01-21 2000-07-27 Georgetown University Lipoplexe et polyplexe stabilises selon un procede de post-application d'un ligand-peg dans l'administration ciblee de genes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4215820B2 (ja) * 1995-06-07 2009-01-28 イマアーレクス・フアーマシユーチカル・コーポレーシヨン 診断的および治療的使用のための新規な標的化組成物
AU4907897A (en) * 1996-10-11 1998-05-11 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method
EP1046394A3 (fr) * 1999-04-19 2001-10-10 ImaRx Pharmaceutical Corp. Nouvelles compositions utilisables pour la délivrance de composés dans une cellule
WO2001064743A1 (fr) * 2000-03-02 2001-09-07 Mitsubishi Pharma Corporation CONSTRUCTION A LIAISON GPib-LIPIDE ET UTILISATION CORRESPONDANTE

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016202A2 (fr) * 1996-10-11 1998-04-23 Sequus Pharmaceuticals, Inc. Composition a base de liposomes fusogenes et procede correspondant
WO1998046208A1 (fr) * 1997-04-17 1998-10-22 The Regents Of The University Of Michigan Systeme de delivrance d'adn de follicule pileux
WO1998051285A2 (fr) * 1997-05-15 1998-11-19 Genzyme Corporation Formulations amphiphiles cationiques
WO1999005094A1 (fr) * 1997-07-23 1999-02-04 Ribozyme Pharmaceuticals, Incorporated Nouvelles compositions d'administration de molecules chargees negativement
WO1999005303A1 (fr) * 1997-07-24 1999-02-04 Inex Pharmaceuticals Corporation Preparation de particules de lipides-acides nucleiques grace a un procede d'extraction par solvant et d'hydratation directe
WO1999065461A2 (fr) * 1998-06-19 1999-12-23 Genzyme Corporation Complexes micellaires d'amphiphiles cationiques
WO2000043043A1 (fr) * 1999-01-21 2000-07-27 Georgetown University Lipoplexe et polyplexe stabilises selon un procede de post-application d'un ligand-peg dans l'administration ciblee de genes

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
ANWER K ET AL: "OPTIMIZATION OF CATIONIC LIPID/DNA COMPLEXES FOR SYSTEMIC GENE TRANSFER TO TUMOR LESIONS", JOURNAL OF DRUG TARGETING,HARWOOD ACADEMIC PUBLISHERS GMBH,DE, vol. 8, no. 2, 2000, pages 125 - 135, XP000951678, ISSN: 1061-186X *
ARUNA NATHAN ET AL: "COPOLYMERS OF LYSINE AND POLYETHYLENE GLYCOL: A NEW FAMILY OF FUNCTIONALIZED DRUG CARRIERS", BIOCONJUGATE CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY, WASHINGTON, vol. 4, no. 1, 1993, pages 54 - 62, XP000336592, ISSN: 1043-1802 *
BHATTACHARYA S V ET AL: "Synthesis of novel cationic lipids with oxyethylene spacers at the linkages between hydrocarbon chains and pseudoglyceryl backbone", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 40, no. 46, 12 November 1999 (1999-11-12), pages 8167 - 8171, XP004180445, ISSN: 0040-4039 *
CHEN TAO ET AL: "Fluorescent-labeled poly(ethylene glycol) lipid conjugates with distal cationic headgroups.", BIOCONJUGATE CHEMISTRY, vol. 11, no. 3, May 2000 (2000-05-01), pages 433 - 437, XP002157295, ISSN: 1043-1802, Retrieved from the Internet <URL:http://pubs.acs.org/CHECKCCIP-979559877/isubscribe/journals/bcches/asap/pdf/bc990171x.pdf> [retrieved on 20000330] *
HASELGRUBLER T ET AL: "SYNTHESIS AND APPLICATIONS OF A NEW POLY(ETHYLENE GLYCOL) DERIVATIVE FOR THE CROSSLINKING OF AMINES WITH THIOLS", BIOCONJUGATE CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY, WASHINGTON, vol. 6, no. 3, 1 May 1995 (1995-05-01), pages 242 - 248, XP000505483, ISSN: 1043-1802 *
JAGUR-GRODZINSKI J: "Biomedical application of functional polymers", REACTIVE & FUNCTIONAL POLYMERS,NL,ELSEVIER SCIENCE PUBLISHERS BV, vol. 39, no. 2, 15 February 1999 (1999-02-15), pages 99 - 138, XP004160680, ISSN: 1381-5148 *
MACIAN M ET AL: "Preliminary studies of the toxic effects of non-ionic surfactants derived from lysine.", TOXICOLOGY, JAN 8 1996, VOL. 106, NO. 1-3, PAGE(S) 1-9, XP000978704 *
MORI A ET AL: "STABILIZATION AND REGULATED FUSION OF LIPOSOMES CONTAINING A CATIONIC LIPID USING AMPHIPATHIC POLYETHYLENEGLYCOL DERIVATIVES", JOURNAL OF LIPOSOME RESEARCH,US,MARCEL DEKKER, NEW YORK, vol. 8, no. 2, 1 May 1998 (1998-05-01), pages 195 - 211, XP000752693, ISSN: 0898-2104 *
See also references of EP1173600A2 *
TRUBETSKOY V S ET AL: "NEW APPROACHES IN THE CHEMICAL DESIGN OF GD-CONTAINING LIPOSOMES FOR USE IN MAGNETIC RESONANCE IMAGING OF LYMPH NODES", JOURNAL OF LIPOSOME RESEARCH,US,MARCEL DEKKER, NEW YORK, vol. 4, no. 2, 1994, pages 961 - 980, XP000619021, ISSN: 0898-2104 *
TRUBETSKOY V.S. ET AL: "New approaches in the chemical design of Gd-containing liposomes for use in magnetic resonance imaging of lymph nodes", JOURNAL OF LIPOSOME RESEARCH, 1994, VOL. 4, NO. 2, PAGE(S) 961-983, XP000978705 *
VESKA TONCHEVAL ET AL: "BLOCK COPOLYMERS WITH pH-DEPENDENT SECONDARYSTRUCTURE", JOURNAL OF CONTROLLED RELEASE, vol. 48, no. 2 - 3, October 1997 (1997-10-01), pages 301 - 302, XP002157296, ISSN: 0168-3659 *
WEISSIG V ET AL: "Long-circulating gadolinium-loaded liposomes: potential use for magnetic resonance imaging of the blood pool", COLLOIDS AND SURFACES B (BIOINTERFACES), OCT. 2000, ELSEVIER, NETHERLANDS, vol. 18, no. 3-4, pages 293 - 299, XP000971876, ISSN: 0927-7765 *
ZALIPSKY S ET AL: "LONG CIRCULATING, CATIONIC LIPOSOMES CONTAINING AMINO-PEG-PHOSPHATIDYLETHANOLAMINE", FEBS LETTERS,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM,NL, vol. 353, 1994, pages 71 - 74, XP002920144, ISSN: 0014-5793 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9655822B2 (en) 2004-05-25 2017-05-23 Basf Beauty Care Solutions France S.A.S. Hydrated lamellar phases or liposomes which contain a fatty monoamine or a cationic polymer which promotes intracellular penetration, and a cosmetic or pharmaceutical composition containing same, as well as a method of screening such a substance
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents

Also Published As

Publication number Publication date
AU783647B2 (en) 2005-11-17
JP2002542341A (ja) 2002-12-10
JP2012122075A (ja) 2012-06-28
JP5117648B2 (ja) 2013-01-16
AU4096200A (en) 2000-11-02
CA2370690A1 (fr) 2000-10-26
EP1173600A2 (fr) 2002-01-23
WO2000062813A2 (fr) 2000-10-26

Similar Documents

Publication Publication Date Title
WO2000062813A3 (fr) Lipides peg cationiques et méthodes d&#39;utilisation
WO2003068144A3 (fr) Agents cytotoxiques supportant une fraction reactive de polyethyleneglycol, conjugues cytotoxiques comprenant des groupes de liaison de polyethyleneglycol et leurs procedes de fabrication et d&#39;utilisation
WO2000065024A3 (fr) Micelles polymeriques hyperramifiees destinees a encapsuler et transporter des molecules hydrophobes
WO2001062299A3 (fr) Conjugues polymeres hydrosolubles d&#39;acide artelinique
WO2001095884A3 (fr) Preparations d&#39;inhibiteurs de benzoquinazoline thymidylate synthase en liposomes
WO2002034236A3 (fr) Formulations de lipides pour une administration ciblee
WO2003000233A3 (fr) Liberation de petites molecules hydrophiles comprises dans des vesicules lipidiques
ATE511834T1 (de) Stealth lipid-nanokapseln, verfahren zu ihrer herstellung und ihre verwendung als träger von wirkstoff(en)
WO2000040203A3 (fr) Agents d&#39;administration polymeres et composes d&#39;agents d&#39;administration
CA2393638A1 (fr) Procede de preparation d&#39;esters de 1-benzotriazolyl carbonate de poly(ethylene glycol)
AU1928501A (en) Formulations for pharmaceutical agents ionizable as free acids or free bases
WO1998019709A3 (fr) Reactifs cationiques pour transfection
WO2002097116A3 (fr) Systeme de delivrance d&#39;acides nucleiques
CA2252055A1 (fr) Liposomes entrainant une fusion
EP2471512A3 (fr) Formulations des agents photosensibilisants non-polaires pour la thérapie photodynamique
NZ515270A (en) Esters of L-carnitine or alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds
WO2001004135A3 (fr) Compositions de condensat d&#39;adn reticule et techniques d&#39;administration de genes
AU2102101A (en) Use of cationic lipids for intracellular protein delivery
EP1068306A4 (fr) Derives de lipides de pentaerythritol
EP2452684A3 (fr) Micelles
WO2003102150A3 (fr) Polyamines multifonctionnelles destinees a l&#39;apport de polynucleotides biologiquement actifs
WO1999047101A3 (fr) Compositions contenant des acides lysophosphatidiques qui inhibent l&#39;apoptose et leurs utilisations
WO2000053231A3 (fr) Conjugues d&#39;acides gras et d&#39;agents anticancereux, et utilisations correspondantes
WO2007002886A3 (fr) Compositions et procedes pour l&#39;obtention de complexes proteines-lipides moins immunogenes
WO2003020235A3 (fr) Stabilisation de principes actifs sensibles a l&#39;oxydation et/ou aux u.v.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

ENP Entry into the national phase

Ref document number: 2370690

Country of ref document: CA

Kind code of ref document: A

Country of ref document: CA

Ref document number: 2000 611949

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2000920309

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000920309

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642