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WO2000056298A3 - Treatment of lyme disease with polysulfated glycosaminoglycan formulations - Google Patents

Treatment of lyme disease with polysulfated glycosaminoglycan formulations Download PDF

Info

Publication number
WO2000056298A3
WO2000056298A3 PCT/US2000/006382 US0006382W WO0056298A3 WO 2000056298 A3 WO2000056298 A3 WO 2000056298A3 US 0006382 W US0006382 W US 0006382W WO 0056298 A3 WO0056298 A3 WO 0056298A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
lyme disease
polysulfated glycosaminoglycan
formulations
glycosaminoglycan formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/006382
Other languages
French (fr)
Other versions
WO2000056298A2 (en
WO2000056298A9 (en
Inventor
Richard P Lawrence
Ralf A Lange
Mary Jane Helenek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American Regent Inc
Original Assignee
Luitpold Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luitpold Pharmaceuticals Inc filed Critical Luitpold Pharmaceuticals Inc
Publication of WO2000056298A2 publication Critical patent/WO2000056298A2/en
Publication of WO2000056298A3 publication Critical patent/WO2000056298A3/en
Anticipated expiration legal-status Critical
Publication of WO2000056298A9 publication Critical patent/WO2000056298A9/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compositions and methods for the treatment of Lyme disease associated joint and arthritic symptoms with polysulfated glycosaminoglycans are described.
PCT/US2000/006382 1999-03-19 2000-03-13 Treatment of lyme disease with polysulfated glycosaminoglycan formulations Ceased WO2000056298A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27199199A 1999-03-19 1999-03-19
US09/271,991 1999-03-19

Publications (3)

Publication Number Publication Date
WO2000056298A2 WO2000056298A2 (en) 2000-09-28
WO2000056298A3 true WO2000056298A3 (en) 2001-05-03
WO2000056298A9 WO2000056298A9 (en) 2001-11-29

Family

ID=23037944

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/006382 Ceased WO2000056298A2 (en) 1999-03-19 2000-03-13 Treatment of lyme disease with polysulfated glycosaminoglycan formulations

Country Status (1)

Country Link
WO (1) WO2000056298A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067144B2 (en) 1998-10-20 2006-06-27 Omeros Corporation Compositions and methods for systemic inhibition of cartilage degradation
DE10053053A1 (en) * 2000-10-19 2002-05-16 Knoell Hans Forschung Ev Pharmaceutical formulations for the inhibition of inflammatory arthritis
US12059430B2 (en) 2022-09-29 2024-08-13 Adora Animal Health Corporation Storage stable formulations of sulfated glycosaminoglycans and fragments derived therefrom for the treatment of pain and other medical conditions

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524066A (en) * 1981-05-11 1985-06-18 Luitpold-Werk Chemisch-Pharmazeutische Fabrik Process for the preparation of injectable chondroitin polysulfate
EP0418827A1 (en) * 1989-09-19 1991-03-27 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Vaccine against Lyme disease
US5036056A (en) * 1987-07-08 1991-07-30 Martin Kludas Methods for treating damaged corneal, uterine, or cartilage tissue
EP0441003A2 (en) * 1989-12-20 1991-08-14 Lawrence Goldman Ophthalmic medication
WO1998024477A1 (en) * 1996-12-06 1998-06-11 Amgen Inc. Combination therapy using an il-1 inhibitor for treating il-1 mediated diseases
US5888514A (en) * 1997-05-23 1999-03-30 Weisman; Bernard Natural composition for treating bone or joint inflammation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524066A (en) * 1981-05-11 1985-06-18 Luitpold-Werk Chemisch-Pharmazeutische Fabrik Process for the preparation of injectable chondroitin polysulfate
US5036056A (en) * 1987-07-08 1991-07-30 Martin Kludas Methods for treating damaged corneal, uterine, or cartilage tissue
EP0418827A1 (en) * 1989-09-19 1991-03-27 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Vaccine against Lyme disease
EP0441003A2 (en) * 1989-12-20 1991-08-14 Lawrence Goldman Ophthalmic medication
WO1998024477A1 (en) * 1996-12-06 1998-06-11 Amgen Inc. Combination therapy using an il-1 inhibitor for treating il-1 mediated diseases
US5888514A (en) * 1997-05-23 1999-03-30 Weisman; Bernard Natural composition for treating bone or joint inflammation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BERKOW R., FLETCHER A.J.: "The Merck Manual of diagnosis and therapy, sixteenth edition.", 1992, MERCK RESEARCH LABORATORIES, RAHWAY, NEW YORK, XP002152604, 215310 *
BUDAVARI S., O'NEIL M., SMITH A., HECKELMAN P.: "The Merck Index Eleventh Edition", 1989, MERCK & CO. , INC., RAHWAY, N.J., XP002152848 *
KONNO S (REPRINT) ET AL: "REGULATORY EFFECTS OF HEPARIN ON LYMPHOCYTE-PROLIFERATION IN LYME -DISEASE PATIENTS", JOURNAL OF IMMUNOLOGY, (15 APR 1993) VOL. 150, NO. 8, PART 2, PP. A155. ISSN: 0022-1767., NEW YORK MED COLL, DEPT MED, VALHALLA, NY, 10595;NEW YORK MED COLL, DEPT BIOCHEM & MOLEC BIOL, VALHALLA, NY, 10595, XP000961371 *
LEONG JOHN M ET AL: "Hemagglutination and proteoglycan binding by the Lyme disease spirochete, Borrelia burgdorferi.", INFECTION AND IMMUNITY, vol. 63, no. 3, 1995, pages 874 - 883, XP000957831, ISSN: 0019-9567 *
WADSTROEM TORKEL ET AL: "Glycosaminoglycan-binding microbial proteins in tissue adhesion and invasion: Key events in microbial pathogenicity.", JOURNAL OF MEDICAL MICROBIOLOGY, vol. 48, no. 3, March 1999 (1999-03-01), pages 223 - 233, XP000957766, ISSN: 0022-2615 *

Also Published As

Publication number Publication date
WO2000056298A2 (en) 2000-09-28
WO2000056298A9 (en) 2001-11-29

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