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WO2000048583A3 - Formulation of 5-ht agonists with nsaids, especially cox-2 inhibitors, for treating migraine - Google Patents

Formulation of 5-ht agonists with nsaids, especially cox-2 inhibitors, for treating migraine Download PDF

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Publication number
WO2000048583A3
WO2000048583A3 PCT/US2000/003897 US0003897W WO0048583A3 WO 2000048583 A3 WO2000048583 A3 WO 2000048583A3 US 0003897 W US0003897 W US 0003897W WO 0048583 A3 WO0048583 A3 WO 0048583A3
Authority
WO
WIPO (PCT)
Prior art keywords
inhibitors
nsaids
treating migraine
agonists
formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/003897
Other languages
French (fr)
Other versions
WO2000048583A2 (en
Inventor
John R Plachetka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pozen Inc
Original Assignee
Pozen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pozen Inc filed Critical Pozen Inc
Priority to AU35965/00A priority Critical patent/AU3596500A/en
Publication of WO2000048583A2 publication Critical patent/WO2000048583A2/en
Publication of WO2000048583A3 publication Critical patent/WO2000048583A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention comprises a method of treating migraine in a human comprising co-timely administering of a therapeutically effective amount of a 5-HT agonist coordinated with a therapeutically effective amount of an NSAID, particularly a long-acting NSAID, and particularly of the class of NSAIDs termed cycloocygenase-2 inhibitors (COX-2 inhibitors) such as celecoxib (Celebrex®), rofecoxib (Vioxx®), meloxicam, piroxicam, JTE-522, L-745,337, and NS398, and in some instances, doses below those ordinarily considered as minimum effective doses as to one or both 5-HT agonist and long-acting NSAID. Dosage forms are included herein.
PCT/US2000/003897 1999-02-19 2000-02-16 Formulation of 5-ht agonists with nsaids, especially cox-2 inhibitors, for treating migraine Ceased WO2000048583A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU35965/00A AU3596500A (en) 1999-02-19 2000-02-16 Formulation of 5-ht agonists with cox-2 inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25327899A 1999-02-19 1999-02-19
US09/253,278 1999-02-19

Publications (2)

Publication Number Publication Date
WO2000048583A2 WO2000048583A2 (en) 2000-08-24
WO2000048583A3 true WO2000048583A3 (en) 2000-12-07

Family

ID=22959600

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/003897 Ceased WO2000048583A2 (en) 1999-02-19 2000-02-16 Formulation of 5-ht agonists with nsaids, especially cox-2 inhibitors, for treating migraine

Country Status (2)

Country Link
AU (1) AU3596500A (en)
WO (1) WO2000048583A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
CA2348979A1 (en) 1998-11-02 2000-05-11 Merck & Co., Inc. Method of treating migraines and pharmaceutical compositions
SA99191255B1 (en) 1998-11-30 2006-11-25 جي دي سيرل اند كو celecoxib compounds
NZ515711A (en) * 1999-06-24 2004-01-30 Pharmacia Corp Combination of tumors necrocis factor (TNF) antagonists and COX-2 inhibitors for the treatment of inflammation
GB9929039D0 (en) * 1999-12-08 2000-02-02 Glaxo Group Ltd Medicaments
GB0002336D0 (en) * 2000-02-01 2000-03-22 Glaxo Group Ltd Medicaments
WO2002017896A2 (en) * 2000-08-29 2002-03-07 Peter Van Patten Combination for the treatment of migraine comprising a cyclooxygenase-2 inhibitor and acetylsalicylic acid
CN1681493A (en) * 2002-07-19 2005-10-12 兰贝克赛实验室有限公司 Taste masked sumatriptan tablets and processes for their preparation
MXPA05006954A (en) 2002-12-26 2005-09-22 Pozen Inc Multilayer Dosage Forms Containing NSAIDs and Triptans.
WO2004098619A2 (en) 2003-05-07 2004-11-18 Osteologix A/S Treating cartilage / bone conditions with water-soluble strontium salts
CN101466368A (en) * 2006-06-15 2009-06-24 诺瓦提斯公司 Compositions comprising tegaserod alone or in combination with a proton pump inhibitor for treating or preventing gastric injury
CA2722743A1 (en) 2008-04-28 2009-11-05 Zogenix, Inc. Novel formulations for treatment of migraine

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2135884A (en) * 1983-03-09 1984-09-12 Sandoz Ltd Analgesic preparations containing tizanidine and paracetamol
DE19542281A1 (en) * 1995-11-14 1997-05-15 Boehringer Ingelheim Kg Use of Epinastin for the treatment of pain
WO1997038986A1 (en) * 1996-04-12 1997-10-23 G.D. Searle & Co. Substituted benzenesulfonamide derivatives as prodrugs of cox-2 inhibitors
WO1998006392A1 (en) * 1996-08-16 1998-02-19 Pozen, Inc. Formulation of 5-ht agonists
WO1998015275A2 (en) * 1996-10-09 1998-04-16 Algos Pharmaceutical Corporation Method and potentiated composition for treating migraine
WO1998020870A1 (en) * 1996-11-12 1998-05-22 Pozen, Inc. Improved treatment of migraine headache
WO2000025779A1 (en) * 1998-11-02 2000-05-11 Merck & Co., Inc. Method of treating migraines and pharmaceutical compositions

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2135884A (en) * 1983-03-09 1984-09-12 Sandoz Ltd Analgesic preparations containing tizanidine and paracetamol
DE19542281A1 (en) * 1995-11-14 1997-05-15 Boehringer Ingelheim Kg Use of Epinastin for the treatment of pain
WO1997038986A1 (en) * 1996-04-12 1997-10-23 G.D. Searle & Co. Substituted benzenesulfonamide derivatives as prodrugs of cox-2 inhibitors
WO1998006392A1 (en) * 1996-08-16 1998-02-19 Pozen, Inc. Formulation of 5-ht agonists
WO1998015275A2 (en) * 1996-10-09 1998-04-16 Algos Pharmaceutical Corporation Method and potentiated composition for treating migraine
WO1998020870A1 (en) * 1996-11-12 1998-05-22 Pozen, Inc. Improved treatment of migraine headache
WO2000025779A1 (en) * 1998-11-02 2000-05-11 Merck & Co., Inc. Method of treating migraines and pharmaceutical compositions

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HAAG: "Kombianalgetika in der Kopfschmerztherapie", DEUTSCHE APOTHEKER ZEITUNG,DE,DEUTSCHER APOTHEKER ZEITUNG, STUTTGART, vol. 4, no. 138, 22 January 1998 (1998-01-22), pages 43 - 48, XP002079370, ISSN: 0011-9857 *
PAVEL AND BALUCH: "Formulation of Antimigraine Mixtures", STN HCA,XX,XX, vol. 8, no. 121, 22 August 1994 (1994-08-22), XP002078672 *

Also Published As

Publication number Publication date
WO2000048583A2 (en) 2000-08-24
AU3596500A (en) 2000-09-04

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