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WO1999039743A3 - Procede de stimulation de la proliferation des cellules hepatiques - Google Patents

Procede de stimulation de la proliferation des cellules hepatiques Download PDF

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Publication number
WO1999039743A3
WO1999039743A3 PCT/US1999/002618 US9902618W WO9939743A3 WO 1999039743 A3 WO1999039743 A3 WO 1999039743A3 US 9902618 W US9902618 W US 9902618W WO 9939743 A3 WO9939743 A3 WO 9939743A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell proliferation
hepatic cell
analogues
aii
promoting hepatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1999/002618
Other languages
English (en)
Other versions
WO1999039743A2 (fr
Inventor
Kathleen E Rodgers
Gere Dizerega
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Southern California USC
Original Assignee
University of Southern California USC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Southern California USC filed Critical University of Southern California USC
Priority to AU25903/99A priority Critical patent/AU2590399A/en
Publication of WO1999039743A2 publication Critical patent/WO1999039743A2/fr
Publication of WO1999039743A3 publication Critical patent/WO1999039743A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/085—Angiotensins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/32—Angiotensins [AT], angiotensinogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne un milieu de culture cellulaire amélioré ainsi que des procédés et des kits destinés à stimuler la prolifération et la différentiation des cellules hépatiques par une croissance en présence de l'angiotensinogène, l'angiotensine I (AI), des analogues de AI, et/ou des fragments de AI et des analogues de ceux-ci, des analogues de l'angiotensine II (AII), des fragments de AII ou des analogues de ceux-ci, et/ou des agonistes du récepteur de AII du type 2 (AT2), seuls ou en association avec d'autres facteurs de croissance et de cytokines.
PCT/US1999/002618 1998-02-09 1999-02-08 Procede de stimulation de la proliferation des cellules hepatiques Ceased WO1999039743A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU25903/99A AU2590399A (en) 1998-02-09 1999-02-08 Method of promoting hepatic cell proliferation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US7410498P 1998-02-09 1998-02-09
US60/074,104 1998-02-09
US10841298P 1998-11-13 1998-11-13
US60/108,412 1998-11-13

Publications (2)

Publication Number Publication Date
WO1999039743A2 WO1999039743A2 (fr) 1999-08-12
WO1999039743A3 true WO1999039743A3 (fr) 1999-09-30

Family

ID=26755260

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/002618 Ceased WO1999039743A2 (fr) 1998-02-09 1999-02-08 Procede de stimulation de la proliferation des cellules hepatiques

Country Status (2)

Country Link
AU (1) AU2590399A (fr)
WO (1) WO1999039743A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000050048A2 (fr) * 1999-02-26 2000-08-31 University Of Pittsburgh Of The Commonwealth System Of Higher Education Transplantation de moelle osseuse pour la regeneration et la reparation hepatique
US6730775B1 (en) 1999-03-23 2004-05-04 University Of Southern California Methods for limiting scar and adhesion formation
AU2002257970B2 (en) 2001-05-31 2007-08-02 Vicore Pharma Ab Tricyclic compounds useful as angiotensin II agonists
EP2455388A1 (fr) 2010-11-23 2012-05-23 LanthioPep B.V. Nouveaux agonistes du récepteur 2 (AT2) de type angiotensine et leurs utilisations
EP4007592A1 (fr) 2019-08-02 2022-06-08 LanthioPep B.V. Agonistes du récepteur de l'angiotensine 2 (at2) destinés à être utilisés dans le traitement du cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014858A1 (fr) * 1994-11-14 1996-05-23 University Of Southern California Utilisation de fragments d'angiotensine ii et d'analogues de celle-ci pour la reparation des tissus
WO1996039164A1 (fr) * 1995-06-06 1996-12-12 The University Of Southern California Utilisation d'agonistes du recepteur type 2 de l'angiotensine ii dans la reparation des tissus
WO1998032457A2 (fr) * 1997-01-28 1998-07-30 University Of Southern California Procede stimulant la proliferation et la differentiation de cellules hematopoietiques et mesenchymateuses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014858A1 (fr) * 1994-11-14 1996-05-23 University Of Southern California Utilisation de fragments d'angiotensine ii et d'analogues de celle-ci pour la reparation des tissus
WO1996039164A1 (fr) * 1995-06-06 1996-12-12 The University Of Southern California Utilisation d'agonistes du recepteur type 2 de l'angiotensine ii dans la reparation des tissus
WO1998032457A2 (fr) * 1997-01-28 1998-07-30 University Of Southern California Procede stimulant la proliferation et la differentiation de cellules hematopoietiques et mesenchymateuses

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DAJANI, OLAV F. ET AL: "Growth-promoting effects of Ca2+-mobilizing agents in hepatocytes: lack of correlation between the acute activation of phosphoinositide-specific phospholipase C and the stimulation of DNA synthesis by angiotensin II, vasopressin, norepinephrine, and prostaglandin F2.alpha.", XP002111087, retrieved from STN Database accession no. 125:213302 HCA *
J. CELL. PHYSIOL. (1996), 168(3), 608-617 *

Also Published As

Publication number Publication date
WO1999039743A2 (fr) 1999-08-12
AU2590399A (en) 1999-08-23

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