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WO1999038185A3 - Spectrometre a source ionique a impulsions et appareil de transmission visant a amortir la mobilite ionique, et procede d'utilisation - Google Patents

Spectrometre a source ionique a impulsions et appareil de transmission visant a amortir la mobilite ionique, et procede d'utilisation Download PDF

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Publication number
WO1999038185A3
WO1999038185A3 PCT/CA1999/000034 CA9900034W WO9938185A3 WO 1999038185 A3 WO1999038185 A3 WO 1999038185A3 CA 9900034 W CA9900034 W CA 9900034W WO 9938185 A3 WO9938185 A3 WO 9938185A3
Authority
WO
WIPO (PCT)
Prior art keywords
ion
ions
transmission device
source
spectrometer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA1999/000034
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English (en)
Other versions
WO1999038185A2 (fr
Inventor
Andrew N Krutchinsky
Alexandre V Loboda
Victor L Spicer
Erich W Ens
Kenneth G Standing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Manitoba
Original Assignee
University of Manitoba
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4162020&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999038185(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to JP2000528992A priority Critical patent/JP4331398B2/ja
Priority to DK99900849.3T priority patent/DK1050061T4/en
Priority to DE1050061T priority patent/DE1050061T1/de
Priority to AT99900849T priority patent/ATE273561T2/de
Priority to DE69919325.7T priority patent/DE69919325T3/de
Application filed by University of Manitoba filed Critical University of Manitoba
Priority to EP99900849.3A priority patent/EP1050061B2/fr
Priority to AU20428/99A priority patent/AU745866B2/en
Publication of WO1999038185A2 publication Critical patent/WO1999038185A2/fr
Publication of WO1999038185A3 publication Critical patent/WO1999038185A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/06—Electron- or ion-optical arrangements
    • H01J49/062—Ion guides
    • H01J49/063—Multipole ion guides, e.g. quadrupoles, hexapoles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Electron Sources, Ion Sources (AREA)

Abstract

L'invention concerne un procédé et un dispositif permettant d'utiliser un appareil ou une interface de transmission ionique entre une source ionique et un spectromètre. L'appareil de transmission ionique peut comprendre un ensemble de tiges multipolaires, et il comporte un gaz d'amortissement permettant d'amortir l'étalement spatial et énergétique d'ions émanant d'une source ionique à impulsions. L'ensemble de tiges multipolaires guide les ions le long d'un trajet ionique, de manière à diriger ces ions vers l'entrée d'un spectromètre de masse. L'invention s'applique en particulier aux sources ioniques de type MALDI (à désorption/ionisation laser de type matriciel), qui produisent un petit jet supersonique d'ions et de molécules de type matriciel. Ce jet, sensiblement non directionnel, peut comporter des ions évoluant dans toutes les directions disponibles depuis la source et ayant une large gamme d'étalement énergétique. L'appareil de transmission ionique peut engendrer différents effets, à savoir entre autres : étalement sensible des ions produits, le long d'un axe ionique, pour engendrer un faisceau quasi-continu; réduction de l'étalement énergétique des ions émis depuis la source; et suppression au moins partielle de la fragmentation non désirée des ions d'analysat. En conséquence, un certain nombre d'impulsions ioniques peuvent être fournies à l'analyseur de temps de vol ou autre spectromètre, pour chaque cycle de la production ionique.
PCT/CA1999/000034 1998-01-23 1999-01-25 Spectrometre a source ionique a impulsions et appareil de transmission visant a amortir la mobilite ionique, et procede d'utilisation Ceased WO1999038185A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU20428/99A AU745866B2 (en) 1998-01-23 1999-01-25 Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
DK99900849.3T DK1050061T4 (en) 1998-01-23 1999-01-25 Spectrometer equipped with pulsed ion source and transmission device for attenuation of ion movement and method of use thereof
DE1050061T DE1050061T1 (de) 1998-01-23 1999-01-25 Spektrometer mit gepulster ionenquelle, kopplungsvorrichting zur dämpfung der ionenbewegung, und methode zur verwendung derselben
AT99900849T ATE273561T2 (de) 1998-01-23 1999-01-25 Spektrometer mit gepulster ionenquelle, kopplungsvorrichtung zur dämpfung der ionenbewegung, und methode zur verwendung derselben
DE69919325.7T DE69919325T3 (de) 1998-01-23 1999-01-25 Spektrometer mit gepulster Ionenquelle, Kopplungsvorrichtung zur Dämpfung der Ionenbewegung, und Methode zur Verwendung derselben
JP2000528992A JP4331398B2 (ja) 1998-01-23 1999-01-25 パルスイオン源及びイオン運動を制動するための輸送デバイスを備えた分析計並びにその使用方法
EP99900849.3A EP1050061B2 (fr) 1998-01-23 1999-01-25 Spectromètre à source ionique à impulsions et appareil de transmission visant à amortir la mobilité ionique, et procédé d'utilisation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002227806A CA2227806C (fr) 1998-01-23 1998-01-23 Spectrometre muni d'une source d'ions pulsee et dispositif de transmission pour amortir la vitesse des ions, et methode d'utilisation
CA2,227,806 1998-01-23

Publications (2)

Publication Number Publication Date
WO1999038185A2 WO1999038185A2 (fr) 1999-07-29
WO1999038185A3 true WO1999038185A3 (fr) 1999-10-21

Family

ID=4162020

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1999/000034 Ceased WO1999038185A2 (fr) 1998-01-23 1999-01-25 Spectrometre a source ionique a impulsions et appareil de transmission visant a amortir la mobilite ionique, et procede d'utilisation

Country Status (8)

Country Link
EP (1) EP1050061B2 (fr)
JP (1) JP4331398B2 (fr)
AT (1) ATE273561T2 (fr)
AU (1) AU745866B2 (fr)
CA (1) CA2227806C (fr)
DE (2) DE1050061T1 (fr)
DK (1) DK1050061T4 (fr)
WO (1) WO1999038185A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8097425B2 (en) 2006-03-10 2012-01-17 Tethys Bioscience, Inc. Multiplex protein fractionation
US9196466B2 (en) 2002-07-24 2015-11-24 Micromass Uk Limited Mass spectrometer with bypass of a fragmentation device

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US5965884A (en) * 1998-06-04 1999-10-12 The Regents Of The University Of California Atmospheric pressure matrix assisted laser desorption
US6849847B1 (en) 1998-06-12 2005-02-01 Agilent Technologies, Inc. Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis
GB9820210D0 (en) * 1998-09-16 1998-11-11 Vg Elemental Limited Means for removing unwanted ions from an ion transport system and mass spectrometer
WO2000077822A2 (fr) 1999-06-11 2000-12-21 Perseptive Biosystems, Inc. Procede et appareil permettant de determiner le poids moleculaire de molecules labiles
DE10010204A1 (de) 2000-03-02 2001-09-13 Bruker Daltonik Gmbh Konditionierung eines Ionenstrahls für den Einschuss in ein Flugzeitmassenspektrometer
DE10010902A1 (de) 2000-03-07 2001-09-20 Bruker Daltonik Gmbh Tandem-Massenspektrometer aus zwei Quadrupolfiltern
CA2340150C (fr) * 2000-06-09 2005-11-22 Micromass Limited Methodes et appareil pour la spectrometrie de masse
US6586727B2 (en) * 2000-06-09 2003-07-01 Micromass Limited Methods and apparatus for mass spectrometry
US6642514B2 (en) 2000-11-29 2003-11-04 Micromass Limited Mass spectrometers and methods of mass spectrometry
GB2370686B (en) 2000-11-29 2003-10-22 Micromass Ltd Mass spectrometers and methods of mass spectrometry
US20020115056A1 (en) 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US6617577B2 (en) 2001-04-16 2003-09-09 The Rockefeller University Method and system for mass spectroscopy
US6849848B2 (en) 2001-09-17 2005-02-01 Mds, Inc. Method and apparatus for cooling and focusing ions
AU2002349241A1 (en) 2001-12-14 2003-06-30 Mds Inc., D.B.A. Mds Sciex Method of chemical of ionization at reduced pressures
WO2003081205A2 (fr) 2002-03-21 2003-10-02 Thermo Finnigan Llc Appareil d'ionisation et procede pour un systeme de spectrometre de masse
US7388194B2 (en) 2002-03-28 2008-06-17 Mds Sciex Inc. Method and system for high-throughput quantitation using laser desorption and multiple-reaction-monitoring
US7405397B2 (en) * 2002-03-28 2008-07-29 Mds Sciex Inc. Laser desorption ion source with ion guide coupling for ion mass spectroscopy
US6930305B2 (en) * 2002-03-28 2005-08-16 Mds, Inc. Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring
GB0210930D0 (en) 2002-05-13 2002-06-19 Thermo Electron Corp Improved mass spectrometer and mass filters therefor
US6977371B2 (en) 2003-06-10 2005-12-20 Micromass Uk Limited Mass spectrometer
DE102004025841B4 (de) * 2004-05-24 2015-07-09 Bruker Daltonik Gmbh Verfahren und Vorrichtung zur massenspektroskopischen Untersuchung von Analyten
GB0420408D0 (en) * 2004-09-14 2004-10-20 Micromass Ltd Mass spectrometer
DE102004051785B4 (de) * 2004-10-25 2008-04-24 Bruker Daltonik Gmbh Proteinprofile mit Luft-MALDI
WO2007064902A2 (fr) 2005-12-02 2007-06-07 Sirtris Pharmaceuticals, Inc. Dosages biologiques par spectrometrie de masse destines a determiner une activite d'acetyltransferase/desacetylase
DE102007043456B4 (de) 2007-07-31 2012-02-09 Bruker Daltonik Gmbh Matrixunterstützte Laserdesorption hoher Ionisierungsausbeute
CN111801574B (zh) * 2018-02-13 2024-02-09 生物梅里埃有限公司 用于确认仪器中带电粒子产生的方法及相关的仪器
US12205807B2 (en) 2020-04-01 2025-01-21 Mstm, Llc Multi-mode ionization apparatus and uses thereof

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DE19511333C1 (de) * 1995-03-28 1996-08-08 Bruker Franzen Analytik Gmbh Verfahren und Vorrichtung für orthogonalen Einschuß von Ionen in ein Flugzeit-Massenspektrometer
US5689111A (en) * 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
WO1999030350A1 (fr) * 1997-12-05 1999-06-17 University Of British Columbia Procede d'analyse d'ions dans un appareil comprenant un spectrometre de masse a temps de vol et un piege a ions lineaire

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US5689111A (en) * 1995-08-10 1997-11-18 Analytica Of Branford, Inc. Ion storage time-of-flight mass spectrometer
WO1999030350A1 (fr) * 1997-12-05 1999-06-17 University Of British Columbia Procede d'analyse d'ions dans un appareil comprenant un spectrometre de masse a temps de vol et un piege a ions lineaire

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KRUTCHINSKY A N ET AL: "Collisional Damping Interface for an Electrospray Ionization Time -of-Flight Mass Spectrometer", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, vol. 9, no. 6, 1 June 1998 (1998-06-01), pages 569-579, XP004122896, ISSN: 1044-0305 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9196466B2 (en) 2002-07-24 2015-11-24 Micromass Uk Limited Mass spectrometer with bypass of a fragmentation device
US9384951B2 (en) 2002-07-24 2016-07-05 Micromass Uk Limited Mass analysis using alternating fragmentation modes
US8097425B2 (en) 2006-03-10 2012-01-17 Tethys Bioscience, Inc. Multiplex protein fractionation

Also Published As

Publication number Publication date
WO1999038185A2 (fr) 1999-07-29
DK1050061T4 (en) 2017-01-23
DK1050061T3 (da) 2004-11-22
CA2227806A1 (fr) 1999-07-23
DE1050061T1 (de) 2001-06-07
CA2227806C (fr) 2006-07-18
EP1050061B1 (fr) 2004-08-11
EP1050061B2 (fr) 2016-10-19
EP1050061A2 (fr) 2000-11-08
DE69919325T2 (de) 2005-02-17
AU745866B2 (en) 2002-04-11
AU2042899A (en) 1999-08-09
JP4331398B2 (ja) 2009-09-16
DE69919325D1 (de) 2004-09-16
DE69919325T3 (de) 2017-03-02
JP2002502084A (ja) 2002-01-22
ATE273561T2 (de) 2004-08-15

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