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WO1999033985A3 - C1F150/hTAFII150 IS NECESSARY FOR CELL CYCLE PROGRESSION - Google Patents

C1F150/hTAFII150 IS NECESSARY FOR CELL CYCLE PROGRESSION Download PDF

Info

Publication number
WO1999033985A3
WO1999033985A3 PCT/US1998/027665 US9827665W WO9933985A3 WO 1999033985 A3 WO1999033985 A3 WO 1999033985A3 US 9827665 W US9827665 W US 9827665W WO 9933985 A3 WO9933985 A3 WO 9933985A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell cycle
htafii150
cif150
cycle progression
progression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1998/027665
Other languages
French (fr)
Other versions
WO1999033985A2 (en
Inventor
Joerg Kaufmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Priority to AU19483/99A priority Critical patent/AU1948399A/en
Publication of WO1999033985A2 publication Critical patent/WO1999033985A2/en
Publication of WO1999033985A3 publication Critical patent/WO1999033985A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A human protein termed CIF150/hTAFII150 recognizes and selects TATA-less core promoters for cell cycle specific genes. Thus, CIF150/hTAFII150 plays an important and selective role in establishing gene expression patterns necessary for progression through the cell cycle. The CIF150/hTAFII150 gene and its expression products can be used to alter the spatial or temporal patterns of mitosis or cell cycle progression of a human cell and to treat disorders involving alterations in the regulation of mitosis or cell cycle progression.
PCT/US1998/027665 1997-12-30 1998-12-28 C1F150/hTAFII150 IS NECESSARY FOR CELL CYCLE PROGRESSION Ceased WO1999033985A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU19483/99A AU1948399A (en) 1997-12-30 1998-12-28 C1f150/h TAF II 150 is necessary for cell cycle progression

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6895697P 1997-12-30 1997-12-30
US60/068,956 1997-12-30

Publications (2)

Publication Number Publication Date
WO1999033985A2 WO1999033985A2 (en) 1999-07-08
WO1999033985A3 true WO1999033985A3 (en) 1999-08-19

Family

ID=22085795

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/027665 Ceased WO1999033985A2 (en) 1997-12-30 1998-12-28 C1F150/hTAFII150 IS NECESSARY FOR CELL CYCLE PROGRESSION

Country Status (2)

Country Link
AU (1) AU1948399A (en)
WO (1) WO1999033985A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4434499A (en) 1998-06-12 1999-12-30 Chiron Corporation Cif130 inhibits cell cycle progression

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994017087A1 (en) * 1993-01-28 1994-08-04 The Regents Of The University Of California Tata-binding protein associated factors, nucleic acids encoding tafs, and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994017087A1 (en) * 1993-01-28 1994-08-04 The Regents Of The University Of California Tata-binding protein associated factors, nucleic acids encoding tafs, and methods of use

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE EMEST 19 E.M.B.L. Databases; 30 October 1996 (1996-10-30), MARRA M ET AL: "Mus musculus cDNA clone 554617 5' similar to:G541665 DTAFII-150 mRNA", XP002106718 *
DATABASE EMROD E.M.B.L. Databases; 1 March 1991 (1991-03-01), WODNAR-FILIPOWICZ A ET AL: "Cloning and sequence analysis of cDNA for rat spleen thymosin beta 4", XP002106719 *
KAUFMANN J ET AL: "CIF, an essential cofactor for TFIID-dependent initiator function", GENES AND DEVELOPMENT, vol. 10, no. 7, 1 April 1996 (1996-04-01), pages 873 - 886, XP002106713 *
KAUFMANN J ET AL: "CIF150, a human cofactor for transcription factor IID-dependent initiator function", MOL. CELL. BIOL., vol. 18, no. 1, January 1998 (1998-01-01), pages 233 - 239, XP002106714 *
MARTINEZ E ET AL: "Novel cofactors and TFIIA mediate functional core promoter selectivity by the human TAFII150-containing TFIID complex", MOL. CELL. BIOL., vol. 18, no. 11, November 1998 (1998-11-01), pages 6571 - 6583, XP002106715 *
VERRIJZER C ET AL: "Drosophila TAFII150: similarity to yeast gene TSM-1 and specific binding to core promoter DNA", SCIENCE, vol. 264, no. 5161, 13 May 1994 (1994-05-13), pages 933 - 941, XP002106716 *
WALKER S ET AL: "Transcription activation in cells lacking TAFIIs", NATURE, vol. 383, 12 September 1996 (1996-09-12), pages 185 - 188, XP002106747 *

Also Published As

Publication number Publication date
WO1999033985A2 (en) 1999-07-08
AU1948399A (en) 1999-07-19

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