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WO1999033958A3 - Desaturase - Google Patents

Desaturase Download PDF

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Publication number
WO1999033958A3
WO1999033958A3 PCT/GB1998/003895 GB9803895W WO9933958A3 WO 1999033958 A3 WO1999033958 A3 WO 1999033958A3 GB 9803895 W GB9803895 W GB 9803895W WO 9933958 A3 WO9933958 A3 WO 9933958A3
Authority
WO
WIPO (PCT)
Prior art keywords
desaturase
seq
fatty acid
relates
acid desaturases
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1998/003895
Other languages
English (en)
Other versions
WO1999033958A2 (fr
Inventor
Johnathan A Napier
Louise Michaelson
Keith Stobart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Bristol
Original Assignee
University of Bristol
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9727256.1A external-priority patent/GB9727256D0/en
Priority claimed from GBGB9814034.6A external-priority patent/GB9814034D0/en
Priority to EP98962620A priority Critical patent/EP1042485A2/fr
Priority to KR1020007007019A priority patent/KR20010033517A/ko
Application filed by University of Bristol filed Critical University of Bristol
Priority to EEP200000372A priority patent/EE200000372A/xx
Priority to HU0101153A priority patent/HUP0101153A3/hu
Priority to BR9814434-0A priority patent/BR9814434A/pt
Priority to AU17748/99A priority patent/AU1774899A/en
Priority to PL98344868A priority patent/PL344868A1/xx
Priority to CA002315297A priority patent/CA2315297A1/fr
Priority to JP2000526616A priority patent/JP2002508932A/ja
Publication of WO1999033958A2 publication Critical patent/WO1999033958A2/fr
Publication of WO1999033958A3 publication Critical patent/WO1999033958A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

L'invention concerne des séquences d'ADNc codant des désaturases d'acide gras-Δ5, comprenant les séquences représentées dans SEQ.1 et SEQ.2.
PCT/GB1998/003895 1997-12-23 1998-12-23 Desaturase Ceased WO1999033958A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CA002315297A CA2315297A1 (fr) 1997-12-23 1998-12-23 Desaturase
JP2000526616A JP2002508932A (ja) 1997-12-23 1998-12-23 デサチュラーゼ
PL98344868A PL344868A1 (en) 1997-12-23 1998-12-23 Desaturase
EP98962620A EP1042485A2 (fr) 1997-12-23 1998-12-23 Desaturase
EEP200000372A EE200000372A (et) 1997-12-23 1998-12-23 Desaturaas
HU0101153A HUP0101153A3 (en) 1997-12-23 1998-12-23 Desaturase
BR9814434-0A BR9814434A (pt) 1997-12-23 1998-12-23 Desaturase
AU17748/99A AU1774899A (en) 1997-12-23 1998-12-23 Desaturase
KR1020007007019A KR20010033517A (ko) 1997-12-23 1998-12-23 불포화화효소

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9727256.1 1997-12-23
GBGB9727256.1A GB9727256D0 (en) 1997-12-23 1997-12-23 Desaturase gene
GB9814034.6 1998-06-29
GBGB9814034.6A GB9814034D0 (en) 1998-06-29 1998-06-29 Desaturase gene

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09582034 A-371-Of-International 2000-12-19
US10/340,779 Continuation US20030152983A1 (en) 1997-12-23 2003-01-13 Desaturase

Publications (2)

Publication Number Publication Date
WO1999033958A2 WO1999033958A2 (fr) 1999-07-08
WO1999033958A3 true WO1999033958A3 (fr) 1999-09-02

Family

ID=26312844

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/003895 Ceased WO1999033958A2 (fr) 1997-12-23 1998-12-23 Desaturase

Country Status (11)

Country Link
EP (1) EP1042485A2 (fr)
JP (1) JP2002508932A (fr)
KR (1) KR20010033517A (fr)
CN (1) CN1283230A (fr)
AU (1) AU1774899A (fr)
BR (1) BR9814434A (fr)
CA (1) CA2315297A1 (fr)
EE (1) EE200000372A (fr)
HU (1) HUP0101153A3 (fr)
PL (1) PL344868A1 (fr)
WO (1) WO1999033958A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087432B2 (en) 2000-09-28 2006-08-08 Bioriginal Food & Science Corp. Fad4, Fad5, Fad5-2 and Fad6, novel fatty acid desaturase family members and uses thereof
US8853432B2 (en) 2004-04-22 2014-10-07 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cell

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8791327B2 (en) 1998-12-07 2014-07-29 Washington State University Research Foundation Desaturases and methods of using them for synthesis of polyunsaturated fatty acids
WO2001092489A2 (fr) * 2000-05-26 2001-12-06 Washington State University Research Foundation Gene desaturase palmitate
GB0107510D0 (en) 2001-03-26 2001-05-16 Univ Bristol New elongase gene and a process for the production of -9-polyunsaturated fatty acids
GB0229578D0 (en) * 2002-12-19 2003-01-22 Univ Bristol Novel method for the production of polyunsaturated fatty acids
GB0403452D0 (en) * 2004-02-17 2004-03-24 Univ York Desaturase enzymes
BRPI0510132A (pt) 2004-04-22 2007-10-02 Commw Scient Ind Res Org sìntese de ácidos graxos poliinsaturados de cadeia longa por células recombinantes
BRPI0511236A (pt) 2004-06-04 2007-11-27 Fluxome Sciences As método para a produção de ácidos graxos poliinsaturados com quatro ou mais ligações duplas, saccharomyces cerevisiae geneticamente modificado que tem capacidade de produzir ácidos graxos poliinsaturados com quatro ou mais ligações duplas quando desenvolvido em um substrato que não de ácido graxo, composição, uso da composição e uso de um saccharomyces cervisiae geneticamente modificado
ATE489463T1 (de) 2004-07-12 2010-12-15 Suntory Holdings Ltd Polypeptid mit einer delta-5-fettsäure- desaturierungsaktivität, für das polypeptid codierendes polynukleotid und verwendung davon.
GB2431158A (en) 2005-10-13 2007-04-18 Rothamsted Res Ltd Process for the production of arachidonic and/or eicosapentaenoic acid
BRPI0716075A2 (pt) 2006-08-29 2013-08-06 Commw Scient Ind Res Org sÍntese de Ácidos graxos
CN101376020B (zh) * 2007-08-29 2013-05-01 益生生技开发股份有限公司 真菌免疫调节蛋白在抑制△5-去饱和酶中的应用
ES2644883T3 (es) 2008-11-18 2017-11-30 Commonwealth Scientific And Industrial Research Organisation Enzimas y métodos para producir ácidos grasos omega-3
PL2861059T3 (pl) 2012-06-15 2017-10-31 Commw Scient Ind Res Org Wytwarzanie długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach roślinnych
US9725399B2 (en) 2013-12-18 2017-08-08 Commonwealth Scientific And Industrial Research Organisation Lipid comprising long chain polyunsaturated fatty acids
SG11201610596PA (en) 2014-06-27 2017-01-27 Commw Scient Ind Res Org Lipid comprising docosapentaenoic acid

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046765A1 (fr) * 1997-04-11 1998-10-22 Calgene Llc Procedes et compositions pour la synthese d'acides gras polyinsatures a chaine longue

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046765A1 (fr) * 1997-04-11 1998-10-22 Calgene Llc Procedes et compositions pour la synthese d'acides gras polyinsatures a chaine longue

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002106765, Database accession no. Z81122 *
DATABASE TREMBL PROTEIN SEQUE 1 January 1900 (1900-01-01), XP002106764, Database accession no. Q94044 *
DEBORAH L. CADENA ET AL.: "The product of the MDL gene is a member of the membrane fatty acid desaturase famiy: Overexpression of MLD inhibits EGF receptor biosynthesis", BIOCHEMISTRY, vol. 36, no. 23, 10 June 1997 (1997-06-10), EASTON, PA US, pages 6960 - 6967, XP002106759 *
KNUTZON D S ET AL: "Identification of Delta5 - desaturase from Mortierella alpina by heterologous expression in Bakers yeast and canola.", JOURNAL OF BIOLOGICAL CHEMISTRY, (1998 NOV 6) 273 (45) 29360-6. JOURNAL CODE: HIV. ISSN: 0021-9258., United States, XP002106760 *
LOUISE V. MICHAELSON ET AL.: "Isolation of a Delta5-fatty acid desaturase gene from Mortierella alpina", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 30, 24 July 1998 (1998-07-24), MD US, pages 19055 - 19059, XP002076636 *
MICHAELSON L V ET AL: "Functional identification of a fatty acid delta5 desaturase gene from Caenorhabditis elegans.", FEBS LETTERS, (1998 NOV 20) 439 (3) 215-8. JOURNAL CODE: EUH. ISSN: 0014-5793., Netherlands, XP002106761 *
OLGA SAYANOVA ET AL.: "Expression of a borage desaturase cDNA containing an N-terminal cytochrome b5 domain results in the accumulation of hig levels of Delta6-desaturated fatty acids in transgenic tobacco", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 94, no. 8, 15 April 1997 (1997-04-15), WASHINGTON US, pages 4211 - 4216, XP002106758 *
R. WILSON ET AL.: "2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans", NATURE, vol. 368, no. 6466, 3 March 1994 (1994-03-03), LONDON GB, pages 32 - 38, XP002106756 *
SPYCHALLA J P ET AL: "Identification of an animal omega-3 fatty acid desaturase by heterologous expression in Arabidopsis.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (1997 FEB 18) 94 (4) 1142-7. JOURNAL CODE: PV3. ISSN: 0027-8424., United States, XP002106757 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087432B2 (en) 2000-09-28 2006-08-08 Bioriginal Food & Science Corp. Fad4, Fad5, Fad5-2 and Fad6, novel fatty acid desaturase family members and uses thereof
US8853432B2 (en) 2004-04-22 2014-10-07 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cell

Also Published As

Publication number Publication date
AU1774899A (en) 1999-07-19
JP2002508932A (ja) 2002-03-26
CN1283230A (zh) 2001-02-07
HUP0101153A3 (en) 2006-03-28
PL344868A1 (en) 2001-11-19
BR9814434A (pt) 2001-10-23
EE200000372A (et) 2001-12-17
EP1042485A2 (fr) 2000-10-11
WO1999033958A2 (fr) 1999-07-08
KR20010033517A (ko) 2001-04-25
HUP0101153A2 (hu) 2001-08-28
CA2315297A1 (fr) 1999-07-08

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